Detailed information for compound 1384926

Basic information

Technical information
  • TDR Targets ID: 1384926
  • Name: methyl 3-[(3-fluorobenzoyl)amino]-5-phenylthi ophene-2-carboxylate
  • MW: 355.383 | Formula: C19H14FNO3S
  • H donors: 1 H acceptors: 2 LogP: 4.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1sc(cc1NC(=O)c1cccc(c1)F)c1ccccc1
  • InChi: 1S/C19H14FNO3S/c1-24-19(23)17-15(11-16(25-17)12-6-3-2-4-7-12)21-18(22)13-8-5-9-14(20)10-13/h2-11H,1H3,(H,21,22)
  • InChiKey: HSIXOIAADLCWSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 3-[(3-fluorobenzoyl)amino]-5-phenyl-thiophene-2-carboxylate
  • 3-[[(3-fluorophenyl)-oxomethyl]amino]-5-phenyl-2-thiophenecarboxylic acid methyl ester
  • 3-[(3-fluorobenzoyl)amino]-5-phenyl-thiophene-2-carboxylic acid methyl ester
  • methyl 3-[(3-fluorophenyl)carbonylamino]-5-phenyl-thiophene-2-carboxylate
  • C908-0086
  • NCGC00114579-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0038 0.0404 0.2384
Trichomonas vaginalis esterase, putative 0.0043 0.0482 0.1427
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0136 0.0214
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0366 0.5151 0.5151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0344
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0099 0.0098
Toxoplasma gondii ABC1 family protein 0.0043 0.0482 0.285
Loa Loa (eye worm) hypothetical protein 0.0449 0.6365 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0822 0.1292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0737 0.0737
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0547 0.3235
Brugia malayi jmjC domain containing protein 0.0016 0.0082 0.0129
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.074 0.1163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.03 0.03
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0133 0.0133
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0012 0.0022 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0381 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Brugia malayi SET domain containing protein 0.0027 0.0244 0.0383
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0008 0.0008
Plasmodium vivax multidomain scavenger receptor, putative 0.0061 0.0737 0.4362
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0482 0.1587
Trypanosoma brucei glycosomal malate dehydrogenase 0.0018 0.0114 0.0666
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0482 0.0757
Echinococcus multilocularis lamin 0.0027 0.0248 0.0248
Echinococcus granulosus expressed protein 0.0379 0.5341 0.5341
Schistosoma mansoni hypothetical protein 0.0061 0.0737 0.0737
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0043 0.0476 0.2819
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0038 0.0404 0.0635
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0209
Brugia malayi Pre-SET motif family protein 0.0031 0.03 0.0471
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0008 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0482 0.0482
Schistosoma mansoni rab6-interacting 0.0061 0.0737 0.0737
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0008 0.002
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0008 0.0034
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0127 0.169 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0098 0.0153
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0426 0.252
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0143 0.0845
Schistosoma mansoni hypothetical protein 0.0049 0.0561 0.0561
Trichomonas vaginalis chromobox protein, putative 0.0062 0.0755 0.2245
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0547 0.6643
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0336 0.0336
Brugia malayi Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein 0.0127 0.169 0.2656
Brugia malayi Cytochrome P450 family protein 0.0011 0.0008 0.0012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.1
Leishmania major mitochondrial malate dehydrogenase 0.0018 0.0114 0.0666
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.1615 0.5377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0002 0.001
Loa Loa (eye worm) fibroinase 0.0017 0.0098 0.0153
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0547 0.1393
Brugia malayi Heterochromatin protein 1 0.0096 0.1239 0.1946
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.1105
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0099 0.0584
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0433 0.2552
Trichomonas vaginalis chromobox protein, putative 0.0096 0.1239 0.3695
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0314 0.0926
Brugia malayi jmjC domain containing protein 0.006 0.0716 0.1125
Entamoeba histolytica protein kinase, putative 0.0012 0.0022 0.0131
Loa Loa (eye worm) hypothetical protein 0.0037 0.0387 0.0609
Leishmania major trypanothione reductase 0.0048 0.0547 0.3228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.0219 0.1294
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.015 0.015
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0136 0.1641
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0038 0.0404 0.0635
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0018 0.0114 0.0676
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0476 0.1411
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0209
Brugia malayi jmjC domain containing protein 0.0016 0.0082 0.0129
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1923 0.1923
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0099
Loa Loa (eye worm) CYP4Cod1 0.002 0.0136 0.0214
Loa Loa (eye worm) hypothetical protein 0.002 0.0143 0.0224
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0038 0.0404 0.2392
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0219 0.064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0114 0.0179
Brugia malayi intermediate filament protein 0.0027 0.0248 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0336 0.0989
Brugia malayi Cytochrome P450 family protein 0.002 0.0136 0.0214
Brugia malayi Smad1 0.0017 0.0099 0.0155
Loa Loa (eye worm) hypothetical protein 0.0043 0.0482 0.0757
Giardia lamblia DINP protein human, muc B family 0.004 0.0433 0.2552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0028 0.0045
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0404 0.1195
Wolbachia endosymbiont of Brugia malayi DNA polymerase III alpha subunit 0.0216 0.298 1
Schistosoma mansoni hypothetical protein 0.0025 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Echinococcus granulosus cytosolic malate dehydrogenase 0.0043 0.0476 0.0476
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0082 0.0082
Echinococcus granulosus WD repeat containing protein 48 0.0105 0.1367 0.1367
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Loa Loa (eye worm) glutathione reductase 0.0048 0.0547 0.0859
Trypanosoma cruzi p450 reductase, putative 0.006 0.0719 0.8745
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0133 0.0209
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0008 0.0071
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0537
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0716 0.0716
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0084 0.0496
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.03 0.03
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0133 0.0133
Loa Loa (eye worm) AGC/AKT protein kinase 0.0012 0.0022 0.0035
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0133 0.0133
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0433 0.2552
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0092 0.0547
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1438 0.3694
Leishmania major cytochrome p450-like protein 0.0011 0.0008 0.0034
Leishmania major cathepsin L-like protease 0.0017 0.0098 0.0568
Loa Loa (eye worm) hypothetical protein 0.005 0.0579 0.0909
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0133 0.0133
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0304
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.1615 0.4152
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0056 0.0667 0.0667
Schistosoma mansoni chromobox protein 0.0096 0.1239 0.1239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.006 0.0719 0.8745
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2921 0.4589
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0426 0.2513
Leishmania major glycosomal malate dehydrogenase 0.0018 0.0114 0.0666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.1173 0.1173
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0133 0.0133
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0084 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0482 0.1225
Leishmania major hypothetical protein, conserved 0.0016 0.0082 0.0476
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0133 0.0133
Schistosoma mansoni cpg binding protein 0.0029 0.0274 0.0274
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.006 0.0719 0.4249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.006 0.0719 0.4255
Echinococcus multilocularis serine:threonine protein kinase 38 0.0012 0.0022 0.0022
Echinococcus granulosus survival motor neuron protein 1 0.024 0.3329 0.3329
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1438 0.3694
Brugia malayi Hr1 repeat family protein 0.0012 0.0022 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0219 0.1294
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0219 0.1294
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0092 0.0537
Trypanosoma brucei trypanothione reductase 0.0048 0.0547 0.3228
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0019 0.0133 0.0209
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0143 0.0224
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0336 0.0336
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0023 0.0183 0.2214
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0063 0.0063
Echinococcus granulosus serine:threonine protein kinase N2 0.0012 0.0022 0.0022
Schistosoma mansoni lozenge 0.0056 0.0669 0.0669
Leishmania major cytochrome P450 reductase, putative 0.0053 0.0621 0.3665
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0008 0.002
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0008 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0727 0.8837
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0727 0.2434
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0038 0.0404 0.4907
Plasmodium vivax vivapain-2 0.0017 0.0098 0.0578
Schistosoma mansoni DNA polymerase IV / kappa 0.001 0.0002 0.0002
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0426 0.2513
Echinococcus multilocularis protein kinase c epsilon type 0.0019 0.0133 0.0133
Leishmania major p450 reductase, putative 0.006 0.0719 0.4249
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0053 0.0621 0.1843
Brugia malayi hypothetical protein 0.024 0.3329 0.523
Schistosoma mansoni L-lactate dehydrogenase 0.0018 0.0114 0.0114
Echinococcus granulosus chromobox protein 2 0.0025 0.0219 0.0219
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0098 0.0153
Mycobacterium tuberculosis Conserved protein 0.0043 0.0482 0.1225
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.03 0.03
Brugia malayi CHD4 protein 0.0027 0.0243 0.0381
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.079 0.9603
Brugia malayi hypothetical protein 0.0061 0.0737 0.1158
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0314 0.0926
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.015 0.015
Echinococcus granulosus Chromo domain 0.0025 0.0219 0.0219
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0002 0.001
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0008 0.002
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0336 0.1978
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0219 0.064
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0822 0.4859
Echinococcus granulosus NDR protein kinase 0.0012 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0008 0.002
Entamoeba histolytica type A flavoprotein, putative 0.0023 0.0183 0.1085
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.015 0.015
Giardia lamblia Malate dehydrogenase 0.0043 0.0476 0.2811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0099 0.0098
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0219 0.0219
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0008 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0084
Toxoplasma gondii malate dehydrogenase MDH 0.0018 0.0114 0.0676
Entamoeba histolytica hypothetical protein 0.0036 0.0381 0.2251
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0008 0.002
Echinococcus multilocularis geminin 0.0336 0.4727 0.4727
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0133 0.0133
Onchocerca volvulus 0.0127 0.169 0.2656
Echinococcus granulosus dna polymerase kappa 0.006 0.0727 0.0727
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0008 0.0071
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0018 0.0114 0.1371
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Brugia malayi Doublecortin family protein 0.0061 0.0737 0.1158
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0099 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0219 0.064
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0092 0.0219
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.079 0.9603
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.1615 0.4152
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0098 0.0568
Entamoeba histolytica hypothetical protein 0.0036 0.0381 0.2251
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0183 0.251 0.251
Brugia malayi MH1 domain containing protein 0.0017 0.0099 0.0155
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0016 0.0025
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0012 0.0022 0.0022
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0695 0.0695
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0695 0.1092
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1983 0.1983
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0008 0.002
Plasmodium vivax JmjC domain containing protein 0.0016 0.0082 0.0486
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0023 0.0183 0.0534
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Echinococcus granulosus neuropeptide s receptor 0.0469 0.6652 0.6652
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0098 0.0098
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0043 0.0476 0.1569
Onchocerca volvulus 0.0017 0.0098 0.0153
Schistosoma mansoni cpg binding protein 0.0031 0.0298 0.0298
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.3329 0.3329
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3879 1
Echinococcus multilocularis bloom syndrome protein 0.002 0.0143 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0263 0.0772
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0763 0.0763
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0012 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0148 0.1992 0.313
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0133 0.0133
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0018 0.0114 0.1371
Loa Loa (eye worm) acetyltransferase 0.0147 0.1983 0.3115
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0023 0.0183 0.0534
Brugia malayi FAD binding domain containing protein 0.006 0.0719 0.113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Schistosoma mansoni DNA helicase recq1 0.002 0.0143 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0336 0.0989
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.006 0.0719 0.4249
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0219 0.064
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0012 0.0022 0.0035
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0744 0.1903
Echinococcus multilocularis tumor protein p63 0.0343 0.4821 0.4821
Brugia malayi hypothetical protein 0.0117 0.1542 0.2423
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0219 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0082 0.0082
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0133 0.0384
Trichomonas vaginalis sulfite reductase, putative 0.006 0.0719 0.2139
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.079 0.9603
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0393 0.2316
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0133 0.0209
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.3478 0.5464
Echinococcus multilocularis lamin dm0 0.0027 0.0248 0.0248
Loa Loa (eye worm) Smad1 0.0017 0.0099 0.0155
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0099 0.0155
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0727 0.4294
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0008 0.0034
Giardia lamblia Nitric oxide synthase, inducible 0.0053 0.0621 0.3665
Plasmodium vivax flavodoxin domain containing protein 0.0053 0.0621 0.3671
Echinococcus multilocularis malate dehydrogenase 0.0018 0.0114 0.0114
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0336 0.0527
Loa Loa (eye worm) hypothetical protein 0.0033 0.0336 0.0527
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0314 0.0926
Loa Loa (eye worm) pyridoxal-dependent decarboxylase 0.0127 0.169 0.2656
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0537
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0098 0.0153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.1105
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0695 0.1776
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0064 0.01
Echinococcus multilocularis cysteine protease 0.0017 0.0098 0.0098
Entamoeba histolytica hypothetical protein 0.0025 0.0219 0.1294
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0217 0.2996 0.7721
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0133 0.0133
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0133 0.0209
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.03 0.1773
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0092 0.0537
Echinococcus multilocularis WD repeat containing protein 48 0.0105 0.1367 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Onchocerca volvulus 0.0017 0.0098 0.0153
Echinococcus granulosus dnaJ subfamily B 0.0415 0.5867 0.5867
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0023 0.0183 0.0534
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0101
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0043 0.0476 0.1211
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.015 0.015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.1105
Brugia malayi Protein kinase domain containing protein 0.0012 0.0022 0.0035
Leishmania major DNA polymerase eta, putative 0.0033 0.0336 0.1978
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0133 0.0133
Loa Loa (eye worm) ctsf protein 0.0017 0.0098 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0092 0.0537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.03 0.03
Entamoeba histolytica malate dehydrogenase, putative 0.0018 0.0114 0.0676
Schistosoma mansoni lamin 0.0027 0.0248 0.0248
Trypanosoma cruzi malate dehydrogenase, putative 0.0018 0.0114 0.1371
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0133 0.0133
Toxoplasma gondii thioredoxin reductase 0.0048 0.0547 0.3235
Brugia malayi Cathepsin L-like precursor 0.0017 0.0098 0.0153
Loa Loa (eye worm) hypothetical protein 0.0449 0.6365 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0482 0.0757
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0038 0.0404 0.0635
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0082 0.0082
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0143 0.0143
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.006 0.0719 0.4249
Echinococcus granulosus bloom syndrome protein 0.002 0.0143 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0219 0.064
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0018 0.0114 0.0076
Leishmania major malate dehydrogenase, putative 0.0018 0.0114 0.0666
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0133 0.0133
Onchocerca volvulus 0.0017 0.0098 0.0153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0084
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0063 0.0063
Schistosoma mansoni chromobox protein 0.0096 0.1239 0.1239
Brugia malayi MH2 domain containing protein 0.025 0.3478 0.5464
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0092 0.1105
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0043 0.0476 0.0476
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0744 0.0744
Brugia malayi Uncoordinated protein 44 0.0015 0.0063 0.0099
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0084 0.0486
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0000070573 0.0000070573
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0219 0.0344
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0143 0.0224
Loa Loa (eye worm) FAD binding domain-containing protein 0.006 0.0719 0.113
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0133 0.0133
Chlamydia trachomatis malate dehydrogenase 0.0043 0.0476 0.133
Echinococcus granulosus lamin 0.0027 0.0248 0.0248
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0012 0.0022 0.0022
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0062 0.0755 0.1186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Schistosoma mansoni loxhd1 0.0061 0.0737 0.0737
Plasmodium falciparum malate dehydrogenase 0.0018 0.0114 0.0666
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0443 0.1126
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0133 0.0133
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0482 0.0482
Leishmania major malate dehydrogenase, putative 0.0018 0.0114 0.0666
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0127 0.169 0.5047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0129
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0482 0.1225
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0482 0.1612
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0716 0.0716
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0695 0.2328
Leishmania major hypothetical protein, conserved 0.0023 0.0183 0.1076
Mycobacterium tuberculosis Diaminopimelate decarboxylase LysA (DAP decarboxylase) 0.0127 0.169 0.4347
Brugia malayi Death domain containing protein 0.0015 0.0063 0.0099
Echinococcus granulosus neuropeptide receptor A26 0.0469 0.6652 0.6652
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0023 0.0183 0.2214
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0482 0.1612
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.1615 0.4152
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0099
Schistosoma mansoni Smad4 0.0017 0.0099 0.0099
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1983 0.1983
Loa Loa (eye worm) doublecortin family protein 0.0061 0.0737 0.1158
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0084
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0482 0.1225
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0133 0.0384
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.072 0.4259
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0822 0.4864
Brugia malayi Cytochrome P450 family protein 0.0049 0.0569 0.0893
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0703 0.2089
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0133 0.0384
Brugia malayi Cathepsin L-like precursor 0.0011 0.0016 0.0025
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0478 0.2829
Onchocerca volvulus 0.0043 0.0482 0.0757
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0219 0.0344
Echinococcus granulosus Chromobox protein 3 0.0025 0.0219 0.0219
Onchocerca volvulus 0.014 0.1881 0.2955
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0038 0.0404 0.2392
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.074 0.074
Treponema pallidum DNA polymerase III subunit alpha 0.0216 0.298 1
Entamoeba histolytica hypothetical protein 0.0025 0.0219 0.1294
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0084 0.0132
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0219 0.1285
Schistosoma mansoni malate dehydrogenase 0.0018 0.0114 0.0114
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.0022 0.0022
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0934 0.0934
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.1105
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0043 0.0476 0.0476
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0482 0.1427
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0133 0.0209
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0695 0.0695
Loa Loa (eye worm) FAD binding domain-containing protein 0.0037 0.0387 0.0608
Trichomonas vaginalis chromobox protein, putative 0.0096 0.1239 0.3695
Loa Loa (eye worm) hypothetical protein 0.0117 0.1542 0.2423
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0482 0.5851
Trypanosoma cruzi cytochrome P450 reductase, putative 0.006 0.0719 0.8745
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0478 0.1417
Toxoplasma gondii cathepsin CPL 0.0017 0.0098 0.0578
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0063 0.0099
Echinococcus multilocularis Smad4 0.0017 0.0099 0.0098
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.0219 0.064
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0482 0.1225
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0008 0.002
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0243 0.0381
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0008 0.002
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0143 0.0224
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.006 0.0719 0.4249
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0336 0.0848
Entamoeba histolytica hypothetical protein 0.0019 0.0133 0.0789
Echinococcus granulosus Polycystic kidney disease protein 0.0061 0.0737 0.0737
Loa Loa (eye worm) beta-lactamase 0.0043 0.0482 0.0757
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0219 0.064
Schistosoma mansoni chromobox protein 0.0025 0.0219 0.0219
Loa Loa (eye worm) malate dehydrogenase 0.0043 0.0476 0.0748
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0056
Brugia malayi Cathepsin L-like precursor 0.0017 0.0098 0.0153
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0008 0.002
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0133 0.0133
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0133 0.0133
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0008 0.002
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0084 0.0486
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0098 0.0568
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0016 0.0016
Brugia malayi CXXC zinc finger family protein 0.0029 0.0274 0.043
Schistosoma mansoni hypothetical protein 0.0045 0.0503 0.0503
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0727 0.4294
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0219 0.064
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0012 0.0022 0.0022
Schistosoma mansoni coup transcription factor 0.001 0.0000070573 0.0000070573
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0022 0.0022
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0695 0.0695
Loa Loa (eye worm) hypothetical protein 0.006 0.0719 0.113
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0547 0.0859
Plasmodium falciparum glutathione reductase 0.0048 0.0547 0.3228
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0143 0.0224
Echinococcus multilocularis dna polymerase eta 0.0033 0.0336 0.0336
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0476 0.1411
Echinococcus granulosus cathepsin l1 0.0017 0.0098 0.0098
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0084 0.0197
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.006 0.0719 0.2409
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0482 0.0757
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0038 0.0404 0.0635
Trichomonas vaginalis ornithine decarboxylase, putative 0.0127 0.169 0.5047
Brugia malayi isocitrate dehydrogenase 0.0016 0.0084 0.0132
Brugia malayi lactate dehydrogenase. 0.0018 0.0114 0.0179
Trypanosoma brucei malate dehydrogenase-related 0.0018 0.0114 0.0666
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0478 0.2829
Schistosoma mansoni thyroid hormone receptor 0.001 0.0000070573 0.0000070573
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0028 0.0045
Schistosoma mansoni cytochrome P450 reductase 0.006 0.0719 0.0719
Echinococcus granulosus cathepsin l1 0.0011 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Trichomonas vaginalis malate dehydrogenase, putative 0.0018 0.0114 0.0327
Entamoeba histolytica type A flavoprotein, putative 0.0023 0.0183 0.1085
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0219 0.1294
Echinococcus multilocularis neuropeptide s receptor 0.0469 0.6652 0.6652
Onchocerca volvulus 0.0017 0.0098 0.0153
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0012 0.0022 0.0022
Echinococcus multilocularis Ankyrin 0.0015 0.0065 0.0065
Brugia malayi Thioredoxin reductase 0.0048 0.0547 0.0859
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0082 0.0979
Loa Loa (eye worm) hypothetical protein 0.014 0.1881 0.2955
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0065 0.0065
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0092 0.0547
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0008 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0314 0.0926
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0282 0.1662
Schistosoma mansoni thyroid hormone receptor 0.001 0.0000070573 0.0000070573
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0082 0.0476
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0098 0.0098
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0404 0.1195
Echinococcus granulosus geminin 0.0336 0.4727 0.4727
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0822 1
Plasmodium vivax DNA repair protein REV1, putative 0.001 0.0002 0.001
Echinococcus multilocularis Protein lozenge 0.0056 0.0669 0.0668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Schistosoma mansoni NADPH flavin oxidoreductase 0.003 0.0289 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0744 0.0744
Leishmania major DNA polymerase kappa, putative 0.004 0.0433 0.2552
Loa Loa (eye worm) hypothetical protein 0.0059 0.0703 0.1104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0744 0.2493
Loa Loa (eye worm) AGC/NDR protein kinase 0.0012 0.0022 0.0035
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0133 0.0133
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0106 0.0106
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0708 0.861
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0082 0.0082
Mycobacterium leprae PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) 0.0049 0.0561 0.1852
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0038 0.0404 0.0404
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0082 0.0082
Echinococcus granulosus lactate dehydrogenase a 0.0018 0.0114 0.0114
Mycobacterium tuberculosis Conserved protein 0.0043 0.0482 0.1225
Brugia malayi Protein kinase domain containing protein 0.0012 0.0022 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0727 0.8837
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0482 0.2843
Schistosoma mansoni microtubule-associated protein tau 0.07 1 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0219 0.1294
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0133 0.0133
Entamoeba histolytica hypothetical protein 0.0036 0.0381 0.2251
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0082 0.0129
Schistosoma mansoni atypical protein kinase C 0.0019 0.0133 0.0133
Schistosoma mansoni lipoxygenase 0.0366 0.5151 0.5151
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0274 0.043
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0098 0.0578
Leishmania major hypothetical protein, conserved 0.0043 0.0482 0.2843
Entamoeba histolytica hypothetical protein 0.0036 0.0381 0.2251
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.0219 0.1285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Giardia lamblia Hypothetical protein 0.0053 0.0621 0.3665
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0092
Entamoeba histolytica cysteine protease, putative 0.0017 0.0098 0.0578
Onchocerca volvulus 0.0011 0.0016 0.0025
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0737 0.0737
Schistosoma mansoni hypothetical protein 0.0336 0.4727 0.4727
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0344
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0183 0.1085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0129
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0091 0.1173 0.1173
Brugia malayi p70 ribosomal S6 kinase beta 0.0012 0.0022 0.0035
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0098 0.0098
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0018 0.0114 0.0114
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0098 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0727 0.8837
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0727 0.2161
Loa Loa (eye worm) hypothetical protein 0.0117 0.154 0.242
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0393 0.2316
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0344
Brugia malayi Protein kinase domain containing protein 0.0012 0.0022 0.0035
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0136 0.1641
Schistosoma mansoni smad 0.0017 0.0099 0.0099
Plasmodium falciparum L-lactate dehydrogenase 0.0018 0.0114 0.0666
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0098 0.1169
Schistosoma mansoni intermediate filament proteins 0.0027 0.0248 0.0248
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0822 0.4859
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0744 0.0744
Echinococcus multilocularis protein kinase c iota type 0.0019 0.0133 0.0133
Echinococcus multilocularis smad 0.0017 0.0099 0.0098
Brugia malayi jmjC domain containing protein 0.0016 0.0082 0.0129
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.006 0.0719 0.0719
Trypanosoma brucei unspecified product 0.0023 0.0185 0.1088
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0219 0.064
Echinococcus granulosus tumor protein p63 0.0343 0.4821 0.4821
Mycobacterium ulcerans hypothetical protein 0.0043 0.0482 0.1612
Echinococcus granulosus lactate dehydrogenase a 0.0018 0.0114 0.0114
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0000070573 0.0000070573
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0219 0.064
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1438 0.3694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0063 0.0099
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0063 0.0099
Schistosoma mansoni cytochrome P450 0.0011 0.0008 0.0008
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0059 0.0703 0.1104
Trichomonas vaginalis ornithine decarboxylase, putative 0.0045 0.0508 0.1507
Mycobacterium tuberculosis Conserved protein 0.0043 0.0482 0.1225
Brugia malayi Cathepsin L-like precursor 0.0017 0.0098 0.0153
Trypanosoma brucei cytosolic malate dehydrogenase 0.0043 0.0476 0.2811
Brugia malayi hypothetical protein 0.0036 0.0381 0.0598
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0716 0.0716
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0737 0.0737
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0143 0.172
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0744 0.4404
Echinococcus granulosus intermediate filament protein 0.0027 0.0248 0.0248
Echinococcus multilocularis Chromo domain 0.0025 0.0219 0.0219
Echinococcus multilocularis microtubule associated protein 2 0.07 1 1
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0008 0.002
Onchocerca volvulus 0.0061 0.0737 0.1158
Entamoeba histolytica type A flavoprotein, putative 0.0023 0.0183 0.1085
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0344
Schistosoma mansoni malate dehydrogenase 0.0018 0.0114 0.0114
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0106 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0098 0.0277
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0209
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0092 0.0261
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0314 0.0926
Brugia malayi hypothetical protein 0.0019 0.0133 0.0209
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0744 0.0744
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0478 0.0478
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0043 0.0476 0.5786
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0099 0.0155
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0133 0.0133
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0143 0.0836
Trichomonas vaginalis malate dehydrogenase, putative 0.0034 0.0342 0.1008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0219 0.0219
Brugia malayi PXA domain containing protein 0.0019 0.0133 0.0209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0000070573 0.0000070573
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1438 0.3694
Entamoeba histolytica protein kinase, putative 0.0012 0.0022 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0482 0.1427
Leishmania major cathepsin L-like protease 0.0065 0.079 0.4666
Echinococcus multilocularis neuropeptide receptor A26 0.0469 0.6652 0.6652
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0133 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0744 0.2493
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0025
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0018 0.0114 0.0179
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.006 0.0719 0.4249
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0012 0.0022 0.0035
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0133 0.0209
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0037 0.0387 0.0387
Chlamydia trachomatis sulfite reductase 0.0037 0.0387 0.1021
Brugia malayi hypothetical protein 0.0019 0.0133 0.0209
Brugia malayi cathepsin L-like precursor 0.0011 0.0016 0.0025
Echinococcus granulosus Smad4 0.0017 0.0099 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Loa Loa (eye worm) hypothetical protein 0.0037 0.0393 0.0617
Plasmodium vivax lactate dehydrogenase 0.0018 0.0114 0.0676
Echinococcus granulosus Protein kinase C brain isozyme 0.0019 0.0133 0.0133
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0023 0.0183 0.1076
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0547 0.0547
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0482 0.0482
Toxoplasma gondii diaminopimelate decarboxylase 0.0127 0.169 1
Brugia malayi MH1 domain containing protein 0.0017 0.0099 0.0155
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0099 0.0099
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0143 0.0845
Leishmania major cytochrome p450-like protein 0.0011 0.0008 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0023 0.0183 0.2214
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0133 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0482 0.0482
Onchocerca volvulus 0.0061 0.0737 0.1158
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0248 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0219 0.1294
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0136 0.0214
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0143 0.0412
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0023 0.0183 0.1076
Leishmania major cathepsin L-like protease 0.0017 0.0098 0.0568
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0082 0.0476
Leishmania major cytochrome p450-like protein 0.002 0.0136 0.0797
Loa Loa (eye worm) hypothetical protein 0.0043 0.0482 0.0757
Echinococcus granulosus L lactate dehydrogenase B chain 0.0018 0.0114 0.0114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0219 0.064
Loa Loa (eye worm) hypothetical protein 0.0152 0.2052 0.3223
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0000070573 0.0000070573
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0016 0.0033
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0084 0.0084
Onchocerca volvulus 0.0027 0.0248 0.039
Echinococcus granulosus death domain containing protein 0.0015 0.0063 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0744 0.2493
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0008 0.0071
Mycobacterium tuberculosis Probable reductase 0.0109 0.1438 0.3694
Echinococcus multilocularis lactate dehydrogenase a 0.0018 0.0114 0.0114
Schistosoma mansoni nuclear hormone receptor 0.001 0.0000070573 0.0000070573
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0063 0.0063
Echinococcus granulosus Ankyrin 0.0015 0.0065 0.0065
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.006 0.0719 0.0719
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0381 0.038
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0589 0.7155
Echinococcus multilocularis chromobox protein 1 0.0096 0.1239 0.1239
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0133 0.0133
Mycobacterium ulcerans error-prone DNA polymerase 0.0216 0.298 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.1105
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.3478 0.5464
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0063 0.0063
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0336 0.0527
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0084 0.0084
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0092
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0727 0.8837
Loa Loa (eye worm) hypothetical protein 0.024 0.3329 0.523
Brugia malayi Cathepsin L-like precursor 0.0017 0.0098 0.0153
Entamoeba histolytica ornithine decarboxylase, putative 0.0127 0.169 1
Brugia malayi beta-lactamase family protein 0.0043 0.0482 0.0757
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0043 0.0043
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0127 0.169 0.5047
Echinococcus multilocularis RUN 0.0061 0.0737 0.0737
Echinococcus multilocularis musashi 0.0027 0.0248 0.0248
Echinococcus multilocularis chromobox protein 1 0.0096 0.1239 0.1239
Onchocerca volvulus 0.0449 0.6365 1
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0018 0.0114 0.1371
Toxoplasma gondii flavodoxin domain-containing protein 0.003 0.0282 0.1669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Mycobacterium leprae Probable lipase LipE 0.0043 0.0482 0.1587
Schistosoma mansoni netrin receptor unc5 0.0015 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0209
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0008 0.002
Entamoeba histolytica hypothetical protein 0.0019 0.0133 0.0789
Loa Loa (eye worm) malate dehydrogenase 0.0018 0.0114 0.0179
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0127 0.169 1
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0098 0.0568
Loa Loa (eye worm) hypothetical protein 0.0027 0.0241 0.0378
Entamoeba histolytica type A flavoprotein, putative 0.0023 0.0183 0.1085
Leishmania major malate dehydrogenase 0.0018 0.0114 0.0666
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0737 0.0737
Trichomonas vaginalis chromobox protein, putative 0.0062 0.0755 0.2245
Schistosoma mansoni lipoxygenase 0.0256 0.3556 0.3556
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0018 0.0114 0.0666
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.074 0.074
Trypanosoma cruzi malate dehydrogenase, putative 0.0018 0.0114 0.1371
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0133 0.0133
Echinococcus granulosus cpg binding protein 0.0031 0.0298 0.0298
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0219 0.1294
Schistosoma mansoni DNA polymerase eta 0.0033 0.0336 0.0336
Onchocerca volvulus 0.0017 0.0098 0.0153
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0019 0.0133 0.0133
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0433 0.1098
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1438 0.4785
Mycobacterium ulcerans malate dehydrogenase 0.0043 0.0476 0.1594
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0038 0.0404 0.2384
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0043 0.0476 0.5786
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0143 0.0143
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0023 0.0183 0.1076
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0143 0.0836
Loa Loa (eye worm) runx1 0.0056 0.0669 0.105
Leishmania major cathepsin L-like protease 0.0017 0.0098 0.0568
Brugia malayi beta-lactamase family protein 0.0043 0.0482 0.0757
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0282 0.1662
Loa Loa (eye worm) hypothetical protein 0.0061 0.0737 0.1158
Brugia malayi beta-lactamase 0.0043 0.0482 0.0757
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0092 0.0145
Plasmodium falciparum nitric oxide synthase, putative 0.006 0.0719 0.4249
Entamoeba histolytica type A flavoprotein, putative 0.0023 0.0183 0.1085
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0082 0.0486
Treponema pallidum flavodoxin 0.0023 0.0183 0.0315
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0695 0.4106
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0822 0.0822
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0822 0.1292
Onchocerca volvulus 0.0117 0.154 0.242
Leishmania major cathepsin L-like protease 0.0065 0.079 0.4666
Schistosoma mansoni malate dehydrogenase 0.0043 0.0476 0.0476
Loa Loa (eye worm) RecQ helicase 0.002 0.0143 0.0224
Mycobacterium ulcerans diaminopimelate decarboxylase LysA 0.0127 0.169 0.5669
Entamoeba histolytica protein kinase, putative 0.0012 0.0022 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Schistosoma mansoni rab6-interacting 0.0061 0.0737 0.0737
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0082 0.0082
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0561 0.0881
Brugia malayi Pre-SET motif family protein 0.0212 0.2921 0.4589
Entamoeba histolytica protein kinase, putative 0.0012 0.0022 0.0131
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0099 0.0098
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0012 0.0022 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0022 0.0022
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.015 0.0236
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0569 0.0893
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0082 0.0082
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0133 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.03 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0133 0.0133
Echinococcus multilocularis malate dehydrogenase 0.0018 0.0114 0.0114
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0000070573 0.0000070573
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0099
Brugia malayi flavodoxin family protein 0.0023 0.0183 0.0288
Schistosoma mansoni survival motor neuron protein 0.0049 0.0561 0.0561
Loa Loa (eye worm) cytochrome P450 0.0011 0.0008 0.0012
Echinococcus granulosus lactate dehydrogenase protein 0.0018 0.0114 0.0114
Plasmodium vivax malate dehydrogenase, putative 0.0018 0.0114 0.0676
Brugia malayi Cathepsin L-like precursor 0.0017 0.0098 0.0153
Brugia malayi Cathepsin L-like precursor 0.0011 0.0016 0.0025
Brugia malayi FAD binding domain containing protein 0.0037 0.0387 0.0608
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0092 0.0547
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0092 0.0537
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0248 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Schistosoma mansoni polycystin 1-related 0.0061 0.0737 0.0737
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0561 0.1665
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.014 0.1881 0.2955
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0008
Echinococcus multilocularis chromobox protein 2 0.0025 0.0219 0.0219
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0219 0.0219
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0243 0.0243
Leishmania major ornithine decarboxylase, putative 0.0127 0.169 1
Toxoplasma gondii lactate dehydrogenase LDH1 0.0018 0.0114 0.0676
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0822 0.0822
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1983 0.3115
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0219 0.1294
Trypanosoma brucei cytochrome P450, putative 0.002 0.0136 0.0797
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0022 0.0022
Echinococcus granulosus methionine synthase reductase 0.0037 0.0387 0.0387
Onchocerca volvulus 0.005 0.0579 0.0909
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0476 0.1411
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0008 0.002
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.0219 0.1294
Entamoeba histolytica hypothetical protein 0.0019 0.0133 0.0789
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0413 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0098 0.0098
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0008 0.002
Onchocerca volvulus 0.0049 0.0561 0.0881
Onchocerca volvulus 0.0027 0.0248 0.039
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0133 0.0209
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0092
Onchocerca volvulus 0.0117 0.154 0.242
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0133 0.0384
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0084 0.1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0579 0.0579
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0098 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0082 0.0129
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0098 0.0153
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0143 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0133 0.0384
Loa Loa (eye worm) helicase 0.0025 0.0219 0.0344
Plasmodium falciparum lactate dehydrogenase, putative 0.0018 0.0114 0.0666
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0478 0.1417
Schistosoma mansoni jumonji domain containing protein 0.006 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0043 0.0482 0.0757
Onchocerca volvulus 0.0043 0.0482 0.0757
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0243 0.0243
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0082 0.0979
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0043 0.0476 0.0748
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0314 0.0926
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0008 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0054 0.063 0.3719
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.5867 0.5867
Schistosoma mansoni lamin 0.0027 0.0248 0.0248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.1105
Schistosoma mansoni cpg binding protein 0.0031 0.0298 0.0298
Loa Loa (eye worm) AGC/PKN protein kinase 0.0012 0.0022 0.0035
Plasmodium falciparum heterochromatin protein 1 0.0025 0.0219 0.1285
Entamoeba histolytica recQ family helicase, putative 0.002 0.0143 0.0845
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0482 0.1427
Loa Loa (eye worm) hypothetical protein 0.0105 0.1367 0.2147
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Schistosoma mansoni hypothetical protein 0.0015 0.0063 0.0063
Echinococcus multilocularis serine:threonine protein kinase N2 0.0012 0.0022 0.0022
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0084 0.0496
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0478 0.2829
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0082 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.027 0.0793
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0038 0.0404 0.4907
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.251 0.251
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0082 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0219 0.064
Brugia malayi MH2 domain containing protein 0.0017 0.0099 0.0155
Echinococcus granulosus cytosolic malate dehydrogenase 0.0043 0.0476 0.0476
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0098 0.0578
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0000070573 0.0000070573
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0183 0.251 0.251
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0133 0.0384
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Loa Loa (eye worm) cysteine protease 0.0017 0.0098 0.0153
Onchocerca volvulus 0.0017 0.0098 0.0153
Trypanosoma brucei ornithine decarboxylase 0.0127 0.169 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0476 0.1411
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0209
Brugia malayi polk-prov protein 0.0037 0.0393 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0282 0.1662
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0183 0.251 0.3943
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0638 0.1003
Echinococcus multilocularis serine threonine protein kinase 0.0012 0.0022 0.0022
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0133 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0482 0.5851
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0038 0.0404 0.2384
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.074 0.074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0314 0.0926
Entamoeba histolytica hypothetical protein 0.0025 0.0219 0.1294
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0413 0.0413
Schistosoma mansoni hypothetical protein 0.0045 0.0503 0.0503
Brugia malayi cytochrome P450 0.0011 0.0008 0.0012
Echinococcus granulosus NADPH cytochrome P450 reductase 0.006 0.0719 0.0719
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0537
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0274 0.0274
Schistosoma mansoni DNA helicase recq5 0.002 0.0143 0.0143
Schistosoma mansoni malate dehydrogenase 0.0043 0.0476 0.0476
Schistosoma mansoni hypothetical protein 0.006 0.0715 0.0715
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0336 0.4071
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0082 0.0082
Echinococcus multilocularis lactate dehydrogenase a 0.0018 0.0114 0.0114
Trichomonas vaginalis pyridoxal-dependent decarboxylase, putative 0.0127 0.169 0.5047
Chlamydia trachomatis DNA polymerase III subunit alpha 0.0216 0.298 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0064 0.01
Trypanosoma cruzi cytochrome P450 reductase, putative 0.006 0.0719 0.8745
Schistosoma mansoni hypothetical protein 0.0336 0.4727 0.4727
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0092 0.0304
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0038 0.0404 0.0404
Leishmania major cathepsin L-like protease 0.0065 0.079 0.4666
Schistosoma mansoni diflavin oxidoreductase 0.003 0.0282 0.0282
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0744 0.4398
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0366 0.5151 0.5151
Echinococcus multilocularis lactate dehydrogenase protein 0.0018 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0027 0.0248 0.039
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0482 0.285
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0133 0.0133
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0000070573 0.0000070573
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0091 0.1173 0.1173
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0547 0.0547
Brugia malayi glutathione reductase 0.0048 0.0547 0.0859
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0092 0.1105
Plasmodium vivax SET domain protein, putative 0.0031 0.03 0.1773
Plasmodium falciparum thioredoxin reductase 0.0048 0.0547 0.3228
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.015 0.015
Echinococcus granulosus chromobox protein 1 0.0096 0.1239 0.1239
Trichomonas vaginalis ornithine decarboxylase, putative 0.0127 0.169 0.5047
Echinococcus granulosus lamin dm0 0.0027 0.0248 0.0248
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0934 0.0934
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0098 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0092 0.0261
Plasmodium vivax glutathione reductase, putative 0.0048 0.0547 0.3235
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0092 0.0537
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0482 0.1225
Echinococcus multilocularis cysteine protease 0.0017 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0098 0.0277
Brugia malayi jmjC domain containing protein 0.0061 0.074 0.1163
Echinococcus granulosus phd:f box containing protein 0.0016 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0031 0.03 0.0471
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0695 0.2328
Onchocerca volvulus 0.0029 0.0274 0.043
Brugia malayi protein kinase C II. 0.0019 0.0133 0.0209
Giardia lamblia Ornithine decarboxylase 0.0127 0.169 1
Echinococcus multilocularis lactate dehydrogenase a 0.0018 0.0114 0.0114
Echinococcus multilocularis dna polymerase kappa 0.006 0.0727 0.0727
Echinococcus granulosus protein kinase C gamma type 0.0012 0.0022 0.0022
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0082 0.0486
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0219 0.064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.079 0.4666
Echinococcus multilocularis 0.0011 0.0008 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0727 0.2434
Brugia malayi Hypothetical WD-repeat protein F35G12.4 in chromosome III 0.0105 0.1367 0.2147
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0217 0.2996 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0482 0.1225
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0092 0.0537
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0314 0.0926
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.0486
Echinococcus multilocularis Polycystic kidney disease protein 0.0061 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0025
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0133 0.0384
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0092 0.0304
Echinococcus multilocularis expressed protein 0.0379 0.5341 0.5341
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0703 0.2089
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.027 0.0793
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0336 0.0336
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0098 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0727 0.4294
Mycobacterium ulcerans hypothetical protein 0.0041 0.0443 0.1482
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1438 0.3694
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0092 0.0547
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0133 0.0133
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0133 0.0209
Echinococcus granulosus malate dehydrogenase 0.0018 0.0114 0.0114
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.0486
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0727 0.2161
Toxoplasma gondii lactate dehydrogenase LDH2 0.0018 0.0114 0.0676
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0008 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0482 0.1427
Onchocerca volvulus 0.0017 0.0098 0.0153
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0098 0.0153
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0336 0.0527
Loa Loa (eye worm) heterochromatin protein 1 0.0096 0.1239 0.1946
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.006 0.0719 0.0719
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.1173 0.1173
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0133 0.0209
Mycobacterium ulcerans lipase LipD 0.0043 0.0482 0.1612
Schistosoma mansoni hypothetical protein 0.0415 0.5867 0.5867
Echinococcus granulosus protein kinase c epsilon type 0.0019 0.0133 0.0133
Onchocerca volvulus 0.0241 0.3346 0.5257
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0219 0.0344
Brugia malayi Protein cec-1. 0.0025 0.0219 0.0344
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0482 0.1427
Loa Loa (eye worm) flavodoxin family protein 0.0023 0.0183 0.0288
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.015 0.0236
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.03 0.03
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0084 0.0496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0098 0.0277
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0084 0.0132
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0092 0.0537
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0143 0.0143
Plasmodium vivax vivapain-2 0.0017 0.0098 0.0578
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0143 0.0412
Toxoplasma gondii flavodoxin domain-containing protein 0.003 0.0282 0.1669
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0092 0.1105
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0143 0.0836
Brugia malayi hypothetical protein 0.0061 0.0737 0.1158
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0344
Leishmania major cathepsin L-like protease 0.0017 0.0098 0.0568
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0025
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0016 0.0033
Schistosoma mansoni serine/threonine kinase 0.0012 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.014 0.1881 0.2955
Brugia malayi M-phase phosphoprotein, mpp8 0.0117 0.154 0.242
Leishmania major cathepsin L-like protease 0.0017 0.0098 0.0568
Brugia malayi map kinase activated protein kinase protein 2 0.0183 0.251 0.3943
Mycobacterium ulcerans DNA polymerase III subunit alpha 0.0216 0.298 1
Leishmania major cytosolic malate dehydrogenase 0.0043 0.0476 0.2811
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0133 0.0133
Onchocerca volvulus 0.0037 0.0387 0.0609
Onchocerca volvulus 0.0043 0.0482 0.0757
Echinococcus granulosus dna polymerase eta 0.0033 0.0336 0.0336
Trichomonas vaginalis set domain proteins, putative 0.0241 0.3344 1
Echinococcus granulosus malate dehydrogenase 0.0018 0.0114 0.0114
Echinococcus granulosus chromobox protein 1 0.0096 0.1239 0.1239
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0022 0.0022
Echinococcus granulosus RUN 0.0061 0.0737 0.0737
Toxoplasma gondii AGC kinase 0.0012 0.0022 0.0131
Schistosoma mansoni hypothetical protein 0.0036 0.0381 0.0381
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0016 0.0096
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0219 0.0219
Brugia malayi Protein kinase domain containing protein 0.0016 0.008 0.0125
Loa Loa (eye worm) hypothetical protein 0.0043 0.0482 0.0757
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0000070573 0.0000070573
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0098 0.0568
Brugia malayi PXA domain containing protein 0.0019 0.0133 0.0209
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0098 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0133 0.0133
Brugia malayi Cytochrome P450 family protein 0.002 0.0136 0.0214
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0082 0.0082
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0248 0.039
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.079 0.9603
Brugia malayi MH2 domain containing protein 0.0017 0.0099 0.0155
Onchocerca volvulus 0.0056 0.0667 0.1048
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0336 0.0336
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0822 0.0822
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0209
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0000070573 0.0000070573
Brugia malayi hypothetical protein 0.0449 0.6365 1
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0038 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0056
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0038 0.0404 0.2392
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0143 0.0836
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0143 0.0143
Brugia malayi jmjC domain containing protein 0.0016 0.0082 0.0129
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0336 0.1986
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0143 0.0836
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.015 0.0236
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0482 0.1225
Brugia malayi flavodoxin family protein 0.006 0.0719 0.113
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0219 0.064
Entamoeba histolytica malate dehydrogenase, putative 0.0043 0.0476 0.2819
Schistosoma mansoni L-lactate dehydrogenase 0.0018 0.0114 0.0114
Echinococcus multilocularis cpg binding protein 0.0031 0.0298 0.0298
Plasmodium falciparum LCCL domain-containing protein 0.0061 0.0737 0.4356
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0092 0.0537
Plasmodium falciparum glutathione reductase 0.0017 0.0092 0.0537
Trypanosoma brucei unspecified product 0.0054 0.063 0.3719
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0012 0.0022 0.0035
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0023 0.0183 0.0534
Schistosoma mansoni chromobox protein 0.0025 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0153
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0082 0.0082
Mycobacterium ulcerans beta-lactamase 0.0043 0.0482 0.1612
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0133 0.0133
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0822 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0136 0.0452
Brugia malayi chromobox protein homolog 3 0.0059 0.0703 0.1104
Echinococcus granulosus protein kinase c iota type 0.0019 0.0133 0.0133
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0217 0.2996 0.7721
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0067
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0043 0.0482 0.0757
Echinococcus multilocularis methionine synthase reductase 0.0037 0.0387 0.0387
Trypanosoma brucei unspecified product 0.0023 0.0185 0.1088
Echinococcus granulosus smad 0.0017 0.0099 0.0098
Toxoplasma gondii hypothetical protein 0.006 0.0715 0.4232
Trypanosoma brucei rac serine-threonine kinase, putative 0.0012 0.0022 0.0121
Plasmodium falciparum thioredoxin reductase 0.0017 0.0092 0.0537
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0476 0.1411
Loa Loa (eye worm) hypothetical protein 0.0061 0.0737 0.1158
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0008 0.002
Trichomonas vaginalis hypothetical protein 0.0025 0.0219 0.064
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0022 0.0051

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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