Detailed information for compound 1397723

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 833.348 | Formula: C21H26N7Na4O17P3
  • H donors: 9 H acceptors: 14 LogP: -6.87 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC1C(O)C(OC1N1C=CCC(=C1)C(=O)N)COP(=O)(OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@H]1O)OP(=O)([O-])[O-])n1cnc2c1ncnc2N)[O-])[O-].[Na+].[Na+].[Na+].[Na+]
  • InChi: 1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10?,11-,13?,14+,15?,16-,20?,21-;;;;/m1..../s1
  • InChiKey: WYWWVJHQDVCHKF-QTXGRHAOSA-J  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Heat shock protein HSP 90-alpha 0.021 0.1193 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0103 0.0109
Echinococcus granulosus chromobox protein 1 0.0084 0.0419 0.0419
Schistosoma mansoni hypothetical protein 0.0047 0.0192 0.0234
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0022 0.0039 0.0039
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0039 0.002
Onchocerca volvulus 0.0315 0.1835 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0129
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0103 0.0129
Echinococcus multilocularis neuropeptide Y receptor 0.0315 0.1835 0.1835
Leishmania major DNA topoisomerase ii 0.0043 0.0166 0.0217
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Schistosoma mansoni amine GPCR 0.0315 0.1835 0.2531
Onchocerca volvulus 0.005 0.0209 0.0946
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0072 0.0346 0.0449
Schistosoma mansoni amine GPCR 0.0315 0.1835 0.2531
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0315 0.1835 0.2546
Brugia malayi GnHR receptor homolog 0.0315 0.1835 0.2546
Chlamydia trachomatis DNA gyrase subunit B 0.0043 0.0166 0.6447
Schistosoma mansoni cellular tumor antigen P53 0.006 0.027 0.0342
Trypanosoma cruzi heat shock protein, putative 0.0086 0.0432 0.0569
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.0762
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0315 0.1835 0.1835
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0121 0.0121
Trypanosoma brucei developmentally regulated phosphoprotein 0.0043 0.0166 0.0198
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0795 0.0795
Echinococcus granulosus heat shock protein 0.021 0.1193 0.1193
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0032 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0347 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0046 0.0075
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0115 0.0607 0.0814
Echinococcus multilocularis neuropeptide FF receptor 2 0.0315 0.1835 0.1835
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.002 0.0027 0.0003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0072 0.0072
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0046 0.0029
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0115 0.0607 0.0814
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0122 0.4419
Loa Loa (eye worm) hypothetical protein 0.0043 0.0165 0.0467
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0046 0.0046
Mycobacterium ulcerans two component regulator - sensor kinase 0.0043 0.0166 0.0198
Onchocerca volvulus 0.0315 0.1835 1
Brugia malayi jmjC domain containing protein 0.0035 0.0121 0.0154
Brugia malayi glutathione reductase 0.0057 0.0254 0.0339
Loa Loa (eye worm) phosphatidylinositol 3 0.0115 0.0607 0.1716
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0192 0.0192
Mycobacterium tuberculosis Possible two component sensor kinase 0.0043 0.0166 0.0198
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0039 0.002
Brugia malayi Dopamine receptor protein 2 0.0315 0.1835 0.2546
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0046 0.0046
Onchocerca volvulus 0.0315 0.1835 1
Schistosoma mansoni heat shock protein 0.0086 0.0432 0.0569
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0022 0.0039 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0108 0.0303
Echinococcus granulosus alpha 1A adrenergic receptor 0.0315 0.1835 0.1835
Trichomonas vaginalis heat shock protein, putative 0.0086 0.0432 0.1479
Giardia lamblia Phosphatidylinositol 4-kinase 0.0022 0.0039 0.0121
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0043 0.0166 0.0708
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0027 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0125 0.0125
Leishmania major cytochrome p450-like protein 0.002 0.0027 0.0023
Schistosoma mansoni rab6-interacting 0.0024 0.005 0.0034
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Echinococcus multilocularis neuropeptide receptor A26 0.0315 0.1835 0.1835
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0072 0.0086
Trypanosoma brucei heat shock protein, putative 0.021 0.1193 0.1633
Echinococcus granulosus neuropeptide receptor A26 0.0315 0.1835 0.1835
Echinococcus granulosus sex peptide receptor 0.0315 0.1835 0.1835
Schistosoma mansoni loxhd1 0.0024 0.005 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Loa Loa (eye worm) hypothetical protein 0.0044 0.0171 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0072 0.0086
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.005 0.021 0.021
Onchocerca volvulus 0.0028 0.0072 0.0186
Onchocerca volvulus 0.0315 0.1835 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0046 0.0049
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0032 0.001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0254 0.0717
Onchocerca volvulus Alhambra homolog 0.0029 0.0083 0.0246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0125 0.0139
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Brugia malayi steroid hormone receptor 0.0028 0.0072 0.0086
Loa Loa (eye worm) hypothetical protein 0.0102 0.0528 0.1492
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0145 0.0168
Trypanosoma cruzi Heat shock protein 83, putative 0.021 0.1193 0.1633
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0196 0.0239
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0027 0.0003
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0315 0.1835 0.1835
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0025 0.002
Schistosoma mansoni hypothetical protein 0.0315 0.1835 0.2531
Schistosoma mansoni opsin-like receptor 0.0315 0.1835 0.2531
Toxoplasma gondii thioredoxin reductase 0.0057 0.0254 0.032
Echinococcus multilocularis g protein coupled receptor 0.0315 0.1835 0.1835
Schistosoma mansoni histamine h1 receptor 0.0315 0.1835 0.2531
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0027 0.0003
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0065 0.03 0.0385
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0115 0.0607 0.0607
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0193 0.0855
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0011 0.003
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.002 0.0027 0.0003
Trichomonas vaginalis receptor histidine kinase, putative 0.0043 0.0166 0.0514
Echinococcus granulosus neuropeptide Y receptor 0.0315 0.1835 0.1835
Toxoplasma gondii hypothetical protein 0.0021 0.0032 0.001
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0048 0.0196 0.0553
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0315 0.1835 0.1835
Plasmodium falciparum glutathione reductase 0.0057 0.0254 0.032
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0022 0.0039 0.002
Trypanosoma brucei Heat shock protein 83, putative 0.021 0.1193 0.1633
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0196 0.0572
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0315 0.1835 0.2531
Echinococcus granulosus endoplasmin 0.0168 0.093 0.093
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0791 0.1068
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0838 0.0838
Mycobacterium leprae Probable two-component sensor kinase 0.0043 0.0166 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0082 0.0207
Loa Loa (eye worm) glutathione reductase 0.0057 0.0254 0.0717
Echinococcus multilocularis expressed protein 0.004 0.0151 0.0151
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0086 0.0432 0.1435
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0046 0.0075
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0043 0.0166 0.0198
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0043 0.0166 0.0198
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0043 0.0166 0.0198
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0072 0.0072
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0527 0.0527
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Leishmania major cytochrome p450-like protein 0.003 0.0088 0.0109
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0469 0.2775 0.2775
Echinococcus granulosus allatostatin A receptor 0.0315 0.1835 0.1835
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0022 0.0039 0.002
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0043 0.0166 0.0514
Echinococcus granulosus expressed protein 0.0451 0.2666 0.2666
Loa Loa (eye worm) neuropeptide F receptor 0.0315 0.1835 0.5188
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0022 0.0039 0.002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0116 0.0116
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0027 0.0003
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0022 0.0039 0.0051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0072 0.0066
Giardia lamblia GTOR 0.0115 0.0607 0.4986
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0205
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0043 0.0166 0.0514
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1187 0.7176 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0022 0.0039 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0027 0.0003
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Schistosoma mansoni chromobox protein 0.0084 0.0419 0.0551
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Brugia malayi Serotonin receptor 0.0315 0.1835 0.2546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0072 0.0205
Plasmodium vivax SET domain protein, putative 0.0036 0.0125 0.0139
Brugia malayi AKH receptor 0.0315 0.1835 0.2546
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.0043 0.0166 0.0198
Schistosoma mansoni biogenic amine receptor 0.0315 0.1835 0.2531
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0046 0.0029
Echinococcus granulosus neuropeptide FF receptor 2 0.0315 0.1835 0.1835
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0072 0.0072
Echinococcus granulosus chromobox protein 1 0.0084 0.0419 0.0419
Brugia malayi Zinc finger, C2H2 type family protein 0.0463 0.2743 0.3814
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0122 0.0135
Toxoplasma gondii DNA topoisomerase 2, putative 0.0043 0.0166 0.0198
Brugia malayi G-protein coupled receptor 0.0315 0.1835 0.2546
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Schistosoma mansoni hypothetical protein 0.002 0.0027 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0072 0.0072
Echinococcus multilocularis somatostatin receptor 0.0315 0.1835 0.1835
Echinococcus multilocularis orexin receptor type 2 0.0315 0.1835 0.1835
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0115 0.0607 0.0814
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0072 0.0072
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0196 0.0239
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0196 0.0239
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0022 0.0039 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0088 0.0249
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Trypanosoma brucei heat shock protein 84, putative 0.0086 0.0432 0.0569
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.005 0.005
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0254 0.032
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0043 0.0166 0.0198
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0046 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0072 0.0066
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0039 0.002
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0046 0.0046
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0043 0.0166 0.0198
Loa Loa (eye worm) hypothetical protein 0.0065 0.03 0.0849
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0029 0.0082 0.0207
Trypanosoma cruzi heat shock protein 85, putative 0.0168 0.093 0.1266
Onchocerca volvulus 0.005 0.0209 0.0947
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0145 0.0168
Onchocerca volvulus 0.006 0.027 0.1284
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0025 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.047
Echinococcus granulosus neuropeptide receptor 0.0315 0.1835 0.1835
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0115 0.0607 0.0833
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.011 0.0119
Schistosoma mansoni hypothetical protein 0.0047 0.0192 0.0234
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0115 0.0607 0.0833
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0046 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0027 0.0003
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.002 0.0027 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0196 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0125 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0121 0.0342
Brugia malayi G protein-coupled receptor 0.0315 0.1835 0.2546
Onchocerca volvulus 0.0286 0.1656 0.9005
Echinococcus multilocularis endoplasmin 0.0168 0.093 0.093
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0043 0.0166 0.0198
Plasmodium falciparum thioredoxin reductase 0.0057 0.0254 0.032
Echinococcus granulosus heat shock protein 90 0.021 0.1193 0.1193
Schistosoma mansoni polycystin 1-related 0.0024 0.005 0.0034
Schistosoma mansoni neuropeptide f receptor 76f 0.0315 0.1835 0.2531
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0192 0.0192
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0346 0.1166
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.002 0.0027 0.0003
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0171 0.0171
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.005 0.005
Trypanosoma brucei cytochrome P450, putative 0.003 0.0088 0.0088
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0115 0.0607 0.0607
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0039 0.011
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.005 0.021 0.021
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0125 0.0125
Loa Loa (eye worm) cytochrome P450 0.002 0.0027 0.0077
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Brugia malayi Bromodomain containing protein 0.0029 0.0083 0.0101
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0043 0.0166 0.0198
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0115 0.0607 0.0814
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.002 0.0027 0.0003
Echinococcus granulosus somatostatin receptor 0.0315 0.1835 0.1835
Entamoeba histolytica hypothetical protein 0.0023 0.0046 0.0024
Onchocerca volvulus 0.0024 0.005 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0165 0.0509
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Loa Loa (eye worm) hypothetical protein 0.0047 0.0193 0.0545
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1187 0.7176 1
Echinococcus granulosus g protein coupled receptor 0.0315 0.1835 0.1835
Mycobacterium ulcerans putative regultory protein 0.0043 0.0166 0.0198
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0064 0.0295 0.0377
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Plasmodium vivax glutathione reductase, putative 0.0057 0.0254 0.032
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0046 0.0075
Schistosoma mansoni hypothetical protein 0.0024 0.005 0.0034
Trypanosoma cruzi heat shock protein 85, putative 0.021 0.1193 0.1633
Echinococcus granulosus dro:myosuppressin receptor 0.0315 0.1835 0.1835
Schistosoma mansoni hypothetical protein 0.0047 0.0192 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0108 0.0301
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0043 0.0165 0.0196
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0088 0.0249
Mycobacterium ulcerans DNA gyrase subunit B 0.0043 0.0166 0.0198
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0315 0.1835 0.1835
Trypanosoma cruzi target of rapamycin kinase 3 0.0115 0.0607 0.0814
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0125 0.0139
Loa Loa (eye worm) hypothetical protein 0.0229 0.1309 0.37
Brugia malayi hypothetical protein 0.0244 0.1401 0.1941
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0072 0.0205
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0022 0.0039 0.011
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0258 0.1487 0.1487
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0046 0.0046
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0315 0.1835 0.1835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0072 0.0205
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.1187 0.7176 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0022 0.0039 0.002
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0027 0.0003
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0064 0.0295 0.0377
Echinococcus granulosus orexin receptor type 2 0.0315 0.1835 0.1835
Plasmodium vivax heat shock protein 90, putative 0.0086 0.0432 0.0569
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0196 0.0239
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0593 0.3537 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0215 0.069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.03 0.1002
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0022 0.0039 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.03 0.1002
Schistosoma mansoni alpha-1 adrenergic receptor 0.0315 0.1835 0.2531
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0025 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0022 0.0039 0.002
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0043 0.0166 0.0198
Trichomonas vaginalis heat shock protein, putative 0.0168 0.093 0.3291
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0315 0.1835 0.2531
Schistosoma mansoni hypothetical protein 0.0022 0.0039 0.002
Schistosoma mansoni endoplasmin 0.021 0.1193 0.1633
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0115 0.0607 0.0814
Loa Loa (eye worm) neuropeptide F receptor 0.0315 0.1835 0.5188
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0043 0.0166 0.0198
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0072 0.0072
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Plasmodium vivax DNA gyrase subunit B, putative 0.0043 0.0166 0.0198
Echinococcus granulosus neuropeptide receptor 0.0315 0.1835 0.1835
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0368
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0022 0.0039 0.0051
Leishmania major heat shock protein, putative 0.0086 0.0432 0.0588
Schistosoma mansoni pyruvate dehydrogenase 0.0043 0.0166 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0121 0.0134
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0203 0.0249
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.002 0.0027 0.0003
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0064 0.0295 0.0377
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0205
Plasmodium vivax heat shock protein 86, putative 0.021 0.1193 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0108 0.0303
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0072 0.0205
Echinococcus granulosus RUN 0.0024 0.005 0.005
Echinococcus granulosus serine protein kinase ATM 0.0065 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0129
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0072 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0346 0.1166
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0083 0.0081
Brugia malayi PXA domain containing protein 0.0023 0.0046 0.0049
Loa Loa (eye worm) hypothetical protein 0.0053 0.0231 0.0654
Echinococcus granulosus intermediate filament protein 0.0033 0.0103 0.0103
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0315 0.1835 0.1835
Schistosoma mansoni hypothetical protein 0.0042 0.0162 0.0191
Echinococcus granulosus tm gpcr rhodopsin 0.0315 0.1835 0.1835
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0215 0.0978
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.011 0.0119
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0072 0.0346 0.0449
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0168 0.093 0.1284
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0115 0.0607 0.0833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0072 0.0205
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0043 0.0166 0.0198
Echinococcus multilocularis tumor protein p63 0.0408 0.2404 0.2404
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0027 0.0003
Echinococcus multilocularis neuropeptide receptor 0.0315 0.1835 0.1835
Schistosoma mansoni adenoreceptor 0.0315 0.1835 0.2531
Onchocerca volvulus 0.0048 0.0196 0.0871
Schistosoma mansoni patched 1 0.0044 0.0171 0.0205
Trichomonas vaginalis heat shock protein, putative 0.0168 0.093 0.3291
Loa Loa (eye worm) hypothetical protein 0.005 0.0211 0.0598
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0702 0.0947
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.062 0.1753
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0072 0.0205
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0022 0.0039 0.002
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1187 0.7176 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0043 0.0166 0.0198
Echinococcus granulosus neuropeptides capa receptor 0.0315 0.1835 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0527 0.0721
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0043 0.0166 0.0198
Brugia malayi heat shock protein 90 0.021 0.1193 0.165
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.1401 0.1401
Trichomonas vaginalis conserved hypothetical protein 0.005 0.021 0.0674
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Schistosoma mansoni fkbp-rapamycin associated protein 0.0065 0.03 0.0385
Brugia malayi PAS domain containing protein 0.0049 0.0203 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0039 0.011
Loa Loa (eye worm) doublecortin family protein 0.0024 0.005 0.014
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Brugia malayi chromobox protein homolog 3 0.0047 0.0193 0.0254
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0027 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0039 0.002
Entamoeba histolytica hypothetical protein 0.0072 0.0347 0.1127
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.014
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0046 0.0046
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0115 0.0607 0.0814
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0072 0.0072
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0072 0.0072
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0125 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Echinococcus granulosus serotonin receptor 0.0315 0.1835 0.1835
Loa Loa (eye worm) heat shock protein 75 0.0086 0.0432 0.1221
Echinococcus multilocularis protein patched 0.0044 0.0171 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0196 0.0239
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0072 0.0086
Brugia malayi intermediate filament protein 0.0033 0.0103 0.0129
Schistosoma mansoni hypothetical protein 0.0047 0.0192 0.0234
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0168 0.093 0.1266
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0235
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0042 0.0162 0.0191
Trypanosoma brucei heat shock protein 90, putative 0.021 0.1193 0.1633
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0315 0.1835 0.2546
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0166 0.0198
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0145 0.0188
Brugia malayi larval opioid receptor 0.0315 0.1835 0.2546
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0046 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0072 0.0072
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0315 0.1835 0.2531
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0274 0.0776
Schistosoma mansoni biogenic amine (5HT) receptor 0.0315 0.1835 0.2531
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0463 0.2743 0.9883
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0043 0.0166 0.0198
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0027 0.0003
Brugia malayi Muscleblind-like protein 0.0152 0.0838 0.1154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0115 0.0607 0.0814
Loa Loa (eye worm) CYP4Cod1 0.003 0.0088 0.0249
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0083 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0528 0.0722
Brugia malayi FAT domain containing protein 0.005 0.021 0.0279
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0209 0.0277
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0046 0.0046
Brugia malayi Cytochrome P450 family protein 0.0064 0.0293 0.0394
Trichomonas vaginalis rotamase, putative 0.004 0.0151 0.0458
Echinococcus granulosus g protein coupled receptor 0.0315 0.1835 0.1835
Schistosoma mansoni hypothetical protein 0.0102 0.0528 0.0703
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0122 0.0135
Echinococcus multilocularis protein dispatched 1 0.005 0.0209 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0027
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0196 0.0239
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0125 0.014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0192 0.0254
Leishmania major hypothetical protein, unknown function 0.0022 0.0039 0.004
Echinococcus granulosus lamin dm0 0.0033 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0029 0.0082 0.0232
Giardia lamblia Heat shock protein HSP 90-alpha 0.0168 0.093 0.7752
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.1187 0.7176 1
Plasmodium falciparum DNA topoisomerase 2 0.0043 0.0166 0.0198
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0027 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0027 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0192 0.0192
Schistosoma mansoni neuropeptide receptor 0.0315 0.1835 0.2531
Echinococcus multilocularis neuropeptide Y receptor 0.0315 0.1835 0.1835
Schistosoma mansoni amine GPCR 0.0315 0.1835 0.2531
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.002 0.0027 0.0003
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0371 0.0484
Trypanosoma brucei heat shock protein 90, putative 0.021 0.1193 0.1633
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0022 0.0039 0.002
Echinococcus multilocularis chromobox protein 1 0.0084 0.0419 0.0419
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0463 0.2743 0.9883
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0022 0.0039 0.0039
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0171 0.0484
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Loa Loa (eye worm) hypothetical protein 0.0152 0.0838 0.2369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0264
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0315 0.1835 0.5188
Onchocerca volvulus Phospholipase A2 homolog 0.0101 0.0521 0.2686
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0029 0.0082 0.008
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0046 0.0029
Trypanosoma brucei heat shock protein, putative 0.021 0.1193 0.1633
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.047
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0043 0.0166 0.0198
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0039 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0193 0.061
Schistosoma mansoni hypothetical protein 0.0165 0.0916 0.1247
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Echinococcus granulosus expressed protein 0.004 0.0151 0.0151
Schistosoma mansoni biogenic amine receptor 0.0315 0.1835 0.2531
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0315 0.1835 0.1835
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0022 0.0039 0.0051
Brugia malayi Cytochrome P450 family protein 0.002 0.0027 0.0023
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0046 0.0046
Echinococcus granulosus neuropeptide s receptor 0.0315 0.1835 0.1835
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0315 0.1835 0.1835
Entamoeba histolytica hypothetical protein 0.0065 0.03 0.0955
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.002 0.0027 0.0003
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.1187 0.7176 1
Echinococcus multilocularis g protein coupled receptor 0.0315 0.1835 0.1835
Trypanosoma cruzi DNA topoisomerase II, putative 0.0043 0.0166 0.0198
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0022 0.0039 0.0051
Schistosoma mansoni hypothetical protein 0.0029 0.0083 0.0081
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0023 0.0046 0.0024
Loa Loa (eye worm) melatonin receptor type 1A 0.0315 0.1835 0.5188
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.002 0.0027 0.0003
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0142 0.0164
Brugia malayi hypothetical protein 0.0164 0.0908 0.1253
Onchocerca volvulus 0.0315 0.1835 1
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0088 0.0088
Echinococcus multilocularis 0.0022 0.0039 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0088 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0027 0.0003
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0022 0.0039 0.0051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0344
Echinococcus multilocularis peregrin 0.0029 0.0083 0.0083
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0072 0.0186
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0315 0.1835 0.1835
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0043 0.0166 0.0198
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0492 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0193 0.061
Brugia malayi Melatonin receptor type 1A 0.0315 0.1835 0.2546
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0115 0.0607 0.0607
Echinococcus multilocularis neuropeptide s receptor 0.0315 0.1835 0.1835
Echinococcus multilocularis lamin dm0 0.0033 0.0103 0.0103
Echinococcus granulosus hypothetical protein 0.0315 0.1835 0.1835
Giardia lamblia PHD finger protein 15 0.0029 0.0083 0.0499
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0072 0.0086
Toxoplasma gondii hypothetical protein 0.0021 0.0032 0.001
Onchocerca volvulus 0.0315 0.1835 1
Onchocerca volvulus 0.0315 0.1835 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0315 0.1835 0.2531
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0315 0.1835 0.2531
Plasmodium vivax heat shock protein, putative 0.0086 0.0432 0.0569
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0209 0.0257
Onchocerca volvulus 0.0315 0.1835 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0039 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Onchocerca volvulus 0.0037 0.013 0.0508
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0029 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0469 0.2775 0.2775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0072 0.0205
Brugia malayi ORL1-like opioid receptor 0.0315 0.1835 0.2546
Brugia malayi Serotonin receptor 0.0315 0.1835 0.2546
Schistosoma mansoni opsin-like receptor 0.0315 0.1835 0.2531
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0046 0.0046
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0171 0.0171
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0086 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0205
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0043 0.0166 0.0198
Leishmania major hypothetical protein, conserved 0.0598 0.357 0.4968
Echinococcus granulosus tm gpcr rhodopsin 0.0315 0.1835 0.1835
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0702 0.0944
Echinococcus granulosus fmrfamide receptor 0.0315 0.1835 0.1835
Loa Loa (eye worm) hypothetical protein 0.0102 0.0527 0.149
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0065 0.03 0.0404
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0039 0.004
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0022 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0791 0.1071
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0043 0.0166 0.0708
Brugia malayi nuclear receptor NHR-88 0.0028 0.0072 0.0086
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0115 0.0607 0.2076
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0022 0.0039 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0315 0.1835 0.5188
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0196 0.0236
Onchocerca volvulus Phospholipase A2 homolog 0.0101 0.0521 0.2686
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0151 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0046 0.0029
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0022 0.0039 0.0121
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0791 0.1071
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0258 0.1487 0.206
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.062 0.1753
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0043 0.0166 0.0198
Brugia malayi Phospholipase A2 family protein 0.0101 0.0521 0.0713
Plasmodium vivax endoplasmin, putative 0.021 0.1193 0.1633
Brugia malayi Dopamine receptor 0.0315 0.1835 0.2546
Brugia malayi PHD-finger family protein 0.0029 0.0083 0.0101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0043 0.0166 0.0198
Brugia malayi hypothetical protein 0.0023 0.0046 0.0049
Echinococcus multilocularis g-protein coupled receptor 0.0315 0.1835 0.1835
Brugia malayi putative neuropeptide receptor 0.0315 0.1835 0.2546
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0702 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0072 0.0086
Brugia malayi jmjC domain containing protein 0.0096 0.0492 0.0671
Brugia malayi ecdysteroid receptor 0.0028 0.0072 0.0086
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Schistosoma mansoni rab6-interacting 0.0024 0.005 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0072 0.0072
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0046 0.0049
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0419 0.1185
Loa Loa (eye worm) hypothetical protein 0.0048 0.0196 0.0553
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0315 0.1835 0.2531
Trypanosoma brucei heat shock protein, putative 0.021 0.1193 0.1633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Onchocerca volvulus 0.0024 0.005 0.0059
Leishmania major developmentally regulated phosphoprotein-like protein 0.0043 0.0166 0.0217
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0072 0.0205
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Brugia malayi RE15519p 0.0315 0.1835 0.2546
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0022 0.0039 0.002
Echinococcus granulosus lamin 0.0033 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0344
Trypanosoma cruzi heat shock protein 85, putative 0.021 0.1193 0.1633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.03 0.1002
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0072 0.0066
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Echinococcus multilocularis serine protein kinase ATM 0.0065 0.03 0.03
Leishmania major hypothetical protein, conserved 0.0043 0.0166 0.0217
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Loa Loa (eye worm) hypothetical protein 0.0048 0.0196 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0072 0.0086
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0142 0.0164
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1187 0.7176 1
Brugia malayi Hsp90 protein 0.0086 0.0432 0.0588
Echinococcus multilocularis lamin 0.0033 0.0103 0.0103
Echinococcus multilocularis neuropeptides capa receptor 0.0315 0.1835 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0046 0.0129
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Loa Loa (eye worm) hypothetical protein 0.0164 0.0908 0.2568
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0086 0.0432 0.2187
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0022 0.0039 0.002
Trypanosoma brucei heat shock protein, putative 0.021 0.1193 0.1633
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0168 0.093 0.1263
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Schistosoma mansoni DNA topoisomerase II 0.0043 0.0166 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0576 0.3435 0.4769
Echinococcus granulosus peptide allatostatin:somatostatin 0.0315 0.1835 0.1835
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.03 0.1002
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Echinococcus granulosus tm gpcr rhodopsin 0.0315 0.1835 0.1835
Plasmodium vivax hypothetical protein 0.0022 0.0039 0.002
Trypanosoma cruzi DNA topoisomerase II, putative 0.0043 0.0166 0.0198
Echinococcus multilocularis fmrfamide receptor 0.0315 0.1835 0.1835
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0022 0.0039 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0072 0.0086
Entamoeba histolytica protein kinase rad3, putative 0.0065 0.03 0.0955
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Brugia malayi G protein-coupled receptor F59B2.13 0.0315 0.1835 0.2546
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0072 0.0186
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0315 0.1835 0.1835
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0492 0.0492
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0192 0.0254
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0469 0.2775 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0315 0.1835 0.1835
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0196 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Giardia lamblia Hypothetical protein 0.0022 0.0039 0.0121
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0315 0.1835 0.2546
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0254 0.0254
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0043 0.0166 0.0514
Brugia malayi kinase, mitochondrial precursor 0.0043 0.0166 0.0217
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Echinococcus multilocularis heat shock protein 90 0.0168 0.093 0.093
Entamoeba histolytica heat shock protein 90, putative 0.021 0.1193 0.4215
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.1187 0.7176 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0121 0.0134
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0215 0.069
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0072 0.0086
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Loa Loa (eye worm) phosphatidylinositol kinase 0.0022 0.0039 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0046 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Echinococcus multilocularis expressed protein 0.0451 0.2666 0.2666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Schistosoma mansoni hypothetical protein 0.0042 0.0162 0.0191
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0315 0.1835 0.2531
Echinococcus granulosus tachykinin peptides receptor 99D 0.0315 0.1835 0.1835
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.03 0.1002
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0315 0.1835 0.1835
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0046 0.0049
Echinococcus multilocularis G protein coupled receptor 139 0.0315 0.1835 0.1835
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0046 0.0029
Brugia malayi neuropeptide F receptor 0.0315 0.1835 0.2546
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0122 0.0122
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0115 0.0607 0.0833
Mycobacterium tuberculosis Probable two component sensor kinase 0.0043 0.0166 0.0198
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0469 0.2775 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0115 0.0607 0.0833
Chlamydia trachomatis DNA gyrase subunit B 0.0043 0.0166 0.6447
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0129
Trypanosoma brucei heat shock protein, putative 0.021 0.1193 0.1633
Trichomonas vaginalis sensor histidine kinase, putative 0.0043 0.0166 0.0514
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0022 0.0039 0.002
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0046 0.0029
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.002 0.0027 0.0003
Schistosoma mansoni neuropeptide F-like receptor 0.0315 0.1835 0.2531
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0022 0.0039 0.002
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0115 0.0607 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.03 0.1002
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0039 0.002
Entamoeba histolytica hypothetical protein 0.0023 0.0046 0.0024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0346 0.0977
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0046 0.0046
Schistosoma mansoni lipoxygenase 0.0067 0.0312 0.0402
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0046 0.0129
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0072 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.011 0.0119
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0029 0.0082 0.008
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0254 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0129
Schistosoma mansoni hypothetical protein 0.005 0.0209 0.0258
Toxoplasma gondii heat shock protein 90, putative 0.021 0.1193 0.1633
Schistosoma mansoni biogenic amine (5HT) receptor 0.0315 0.1835 0.2531
Brugia malayi hypothetical protein 0.0024 0.005 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0816 0.2308
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0039 0.002
Mycobacterium leprae Probable two component sensor kinase MprB 0.0043 0.0166 0.0195
Echinococcus multilocularis fmrfamide receptor 0.0315 0.1835 0.1835
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0791 0.1071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0125 0.0125
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0046 0.0075
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Echinococcus multilocularis g protein coupled receptor 0.0315 0.1835 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Schistosoma mansoni survival motor neuron protein 0.005 0.0209 0.0258
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Loa Loa (eye worm) phosphatidylinositol 3 0.0115 0.0607 0.1716
Plasmodium falciparum heat shock protein 90, putative 0.0086 0.0432 0.0569
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0022 0.0039 0.0051
Echinococcus multilocularis geminin 0.0165 0.0916 0.0916
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0347 0.0347
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0463 0.2743 0.9883
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.047
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0315 0.1835 0.1835
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.002 0.0027 0.0003
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0463 0.2743 0.9883
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Brugia malayi PXA domain containing protein 0.0023 0.0046 0.0049
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.002 0.0027 0.0003
Brugia malayi Cytochrome P450 family protein 0.003 0.0088 0.0108
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0022 0.0039 0.002
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0022 0.0039 0.0039
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0072 0.0072
Brugia malayi Doublecortin family protein 0.0024 0.005 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Trypanosoma brucei trypanothione reductase 0.0057 0.0254 0.032
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.005 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0039 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0196 0.0239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0039 0.004
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0043 0.0166 0.0217
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0151 0.0426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0065 0.03 0.0404
Onchocerca volvulus 0.0315 0.1835 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0072 0.0072
Schistosoma mansoni myosin xvIII 0.0315 0.1835 0.2531
Entamoeba histolytica hypothetical protein 0.0072 0.0347 0.1127
Brugia malayi Pre-SET motif family protein 0.0251 0.1444 0.2
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Schistosoma mansoni hypothetical protein 0.0315 0.1835 0.2531
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0192 0.0192
Brugia malayi nuclear hormone receptor 0.0028 0.0072 0.0086
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0022 0.0039 0.002
Echinococcus multilocularis muscleblind protein 0.0152 0.0838 0.0838
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.002
Trichomonas vaginalis receptor histidine kinase, putative 0.0043 0.0166 0.0514
Echinococcus multilocularis musashi 0.0033 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0315 0.1835 0.2546
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0027 0.0003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0088 0.0088
Schistosoma mansoni biogenic amine receptor 0.0315 0.1835 0.2531
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0027 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0072 0.0066
Echinococcus granulosus g-protein coupled receptor 0.0315 0.1835 0.1835
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0171 0.0532
Toxoplasma gondii hypothetical protein 0.0021 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0101 0.0521 0.1474
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0022 0.0039 0.0121
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0122 0.0135
Schistosoma mansoni neuropeptide F-like receptor 0.0315 0.1835 0.2531
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0831 0.2348
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0043 0.0166 0.0198
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0171 0.0171
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0022 0.0039 0.0051
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0022 0.0039 0.002
Echinococcus multilocularis RUN 0.0024 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0072 0.0086
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0537 0.0716
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0046 0.0029
Echinococcus granulosus GPCR family 2 0.0047 0.0192 0.0192
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0145 0.0168
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0315 0.1835 0.1835
Schistosoma mansoni growth hormone secretagogue receptor 0.0315 0.1835 0.2531
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0315 0.1835 0.1835
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0029 0.0082 0.008
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0022 0.0039 0.0039
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0043 0.0166 0.0195
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0151 0.0458
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0046 0.0029
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0149 0.0816 0.2308
Onchocerca volvulus 0.0033 0.0103 0.0358
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0168 0.093 0.1266
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0122 0.0135
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0196 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Plasmodium falciparum heat shock protein 90, putative 0.0086 0.0432 0.0569
Onchocerca volvulus Neuropeptide F receptor homolog 0.0315 0.1835 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.014
Schistosoma mansoni hypothetical protein 0.0315 0.1835 0.2531
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0022 0.0039 0.002
Brugia malayi Endoplasmin precursor 0.021 0.1193 0.165
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0072 0.0066
Brugia malayi Cytochrome P450 family protein 0.003 0.0088 0.0108
Entamoeba histolytica hypothetical protein 0.0072 0.0347 0.1127
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0027 0.0003
Trichomonas vaginalis endoplasmin, putative 0.0129 0.0694 0.2434
Brugia malayi G-protein coupled receptor 0.0315 0.1835 0.2546
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0029 0.0082 0.0082
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0043 0.0166 0.0198
Trypanosoma brucei heat shock protein, putative 0.021 0.1193 0.1633
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.002 0.0027 0.0003
Loa Loa (eye worm) TOPoisomerase family member 0.0043 0.0166 0.047
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0702 0.0947
Schistosoma mansoni single-minded 0.0049 0.0203 0.0249
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0039 0.004
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0027 0.0003
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0043 0.0166 0.0166
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0065 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0205
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0196 0.0239
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0196 0.0239
Mycobacterium tuberculosis Probable reductase 0.013 0.0702 0.0947
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0315 0.1835 1
Schistosoma mansoni neuropeptide receptor 0.0315 0.1835 0.2531
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0083 0.0081
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0029 0.0082 0.008
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0165 0.0509
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0046 0.0029
Brugia malayi Dopamine receptor protein 1 0.0315 0.1835 0.2546
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0027 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Toxoplasma gondii FATC domain-containing protein 0.0065 0.03 0.0385
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0108 0.0301
Schistosoma mansoni hypothetical protein 0.005 0.021 0.0259
Onchocerca volvulus 0.0315 0.1835 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0115 0.0607 0.0833
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.005 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Loa Loa (eye worm) TYRA-2 protein 0.0315 0.1835 0.5188
Echinococcus multilocularis 0.002 0.0027 0.0027
Brugia malayi hypoxia-induced factor 1 0.0151 0.0831 0.1145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0344
Schistosoma mansoni lipoxygenase 0.0024 0.005 0.0034
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0125 0.016
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.002 0.0027 0.0003
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0046 0.0129
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Trypanosoma cruzi heat shock protein 90, putative 0.021 0.1193 0.1633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0129
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0027 0.0003
Brugia malayi Probable DNA topoisomerase II 0.0043 0.0166 0.0217
Trypanosoma cruzi heat shock protein 90, putative 0.0124 0.0664 0.0894
Toxoplasma gondii heat shock protein HSP90 0.021 0.1193 0.1633
Onchocerca volvulus 0.0315 0.1835 1
Onchocerca volvulus 0.0315 0.1835 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0196 0.0258
Echinococcus granulosus biogenic amine 5HT receptor 0.0315 0.1835 0.1835
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0816 0.1125
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0022 0.0039 0.0051
Brugia malayi Tachykinin-like peptides receptor 99D 0.0315 0.1835 0.2546
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0022 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0344
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0046 0.0049
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0022 0.0039 0.0051
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0022 0.0039 0.002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0103 0.0292
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0046 0.0049
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0115 0.0607 0.0814
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0043 0.0166 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0083 0.0235
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0022 0.0039 0.002
Entamoeba histolytica heat shock protein 90, putative 0.021 0.1193 0.4215
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Schistosoma mansoni dihydroorotate dehydrogenase 0.1187 0.7176 1
Schistosoma mansoni chromobox protein 0.0084 0.0419 0.0551
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0022 0.0039 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0072 0.0066
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0043 0.0166 0.156
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0039 0.0017
Echinococcus multilocularis expressed conserved protein 0.0096 0.0489 0.0489
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0315 0.1835 0.1835
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0046 0.0046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0039 0.004
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0115 0.0607 0.0814
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0293 0.0829
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.011 0.0119
Brugia malayi follicle stimulating hormone receptor 0.0593 0.3537 0.4922
Mycobacterium ulcerans hypothetical protein 0.0048 0.0196 0.0239
Loa Loa (eye worm) heat shock protein 90 0.021 0.1193 0.3372
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0795 0.0795
Onchocerca volvulus 0.0315 0.1835 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0315 0.1835 0.5188
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0029 0.0082 0.008
Trypanosoma brucei heat shock protein, putative 0.021 0.1193 0.1633
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0315 0.1835 0.2531
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1187 0.7176 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0022 0.0039 0.002
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0022 0.0039 0.0039
Echinococcus multilocularis sex peptide receptor 0.0315 0.1835 0.1835
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0029 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0292
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0115 0.0607 0.0814
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0419 0.1433
Plasmodium falciparum heat shock protein 90 0.021 0.1193 0.1633
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0039 0.011
Schistosoma mansoni lamin 0.0033 0.0103 0.0109
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0072 0.0086
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0315 0.1835 0.2531
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.002 0.0027 0.0003
Brugia malayi Thioredoxin reductase 0.0057 0.0254 0.0339
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0065 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0469 0.2775 0.2775
Schistosoma mansoni lamin 0.0033 0.0103 0.0109
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0046 0.0046
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0022 0.0039 0.002
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0702 0.0947
Onchocerca volvulus 0.0315 0.1835 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0315 0.1835 0.1835
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0072 0.0066
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0039 0.004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0192 0.0544
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0043 0.0166 0.0708
Echinococcus granulosus expressed conserved protein 0.0096 0.0489 0.0489
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0838 0.5038 0.5038
Brugia malayi CHE-14 protein 0.0044 0.0171 0.0224
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0072 0.0066
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0027 0.0003
Toxoplasma gondii target of rapamycin (TOR), putative 0.0115 0.0607 0.0814
Plasmodium falciparum dihydroorotate dehydrogenase 0.1187 0.7176 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.1401 0.1401
Schistosoma mansoni hypothetical protein 0.0072 0.0347 0.0451
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0043 0.0166 0.0198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0072 0.0086
Loa Loa (eye worm) hypothetical protein 0.0244 0.1401 0.3961
Mycobacterium ulcerans two component sensor kinase MprB 0.0043 0.0166 0.0198
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0527 0.1784
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0022 0.0039 0.002
Plasmodium falciparum phd finger protein, putative 0.0029 0.0083 0.0081
Echinococcus multilocularis serotonin receptor 0.0315 0.1835 0.1835
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0046 0.0046
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.005 0.005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0315 0.1835 0.1835
Echinococcus granulosus rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Echinococcus granulosus biogenic amine 5HT receptor 0.0315 0.1835 0.1835
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0816 0.1125
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0039 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0072 0.0072
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0122 0.0345
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0046 0.0129
Echinococcus granulosus g protein coupled receptor 0.0315 0.1835 0.1835
Brugia malayi neuropeptide F receptor 0.0315 0.1835 0.2546
Onchocerca volvulus 0.0315 0.1835 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0029 0.0082 0.0207
Brugia malayi hypothetical protein 0.0024 0.005 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0205
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.1187 0.7176 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0312 0.0312
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0315 0.1835 0.2531
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0032 0.001
Trichomonas vaginalis heat shock protein, putative 0.0129 0.0694 0.2434
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0469 0.2775 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0022 0.0039 0.004
Echinococcus granulosus peregrin 0.0029 0.0083 0.0083
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0527 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0032 0.001
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0022 0.0039 0.002
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0254 0.0254
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0027 0.0003
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0043 0.0166 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0032 0.001
Onchocerca volvulus 0.0033 0.0103 0.0358
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0046 0.0046
Schistosoma mansoni heat shock protein 0.021 0.1193 0.1633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0196 0.0258
Onchocerca volvulus 0.0315 0.1835 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0039 0.011
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1656 0.5932
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0315 0.1835 0.1835
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0072 0.0186
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0022 0.0039 0.004
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0027 0.0023
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0043 0.0166 0.156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0051
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0043 0.0166 0.0514
Brugia malayi MH2 domain containing protein 0.0117 0.062 0.085
Brugia malayi putative neuropeptide receptor NPR1 0.0315 0.1835 0.2546
Echinococcus multilocularis serotonin receptor 0.0315 0.1835 0.1835
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0168 0.093 0.093
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0121 0.0121
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Plasmodium vivax DNA topoisomerase II, putative 0.0043 0.0166 0.0198
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0046 0.0075
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0043 0.0166 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0125 0.0139
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0027
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.002 0.0027 0.0003
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0065 0.03 0.0955
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0258 0.1487 0.1487
Loa Loa (eye worm) hypothetical protein 0.0101 0.0521 0.1474
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0046 0.0029
Schistosoma mansoni hypothetical protein 0.0042 0.0162 0.0191
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0022 0.0039 0.004
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0027 0.0003
Loa Loa (eye worm) endoplasmin 0.021 0.1193 0.3372
Loa Loa (eye worm) hypothetical protein 0.0032 0.01 0.0282
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0196 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0046 0.0075
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0046 0.0129
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0086 0.0432 0.0432
Echinococcus granulosus geminin 0.0165 0.0916 0.0916
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0065 0.03 0.0385
Echinococcus granulosus heat shock protein 90 0.0168 0.093 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.03 0.1002
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0022 0.0039 0.0039
Entamoeba histolytica hypothetical protein 0.0072 0.0347 0.1127
Echinococcus multilocularis heat shock protein 0.021 0.1193 0.1193
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0315 0.1835 0.5188
Trypanosoma brucei DNA topoisomerase ii 0.0043 0.0166 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Trypanosoma brucei heat shock protein, putative 0.021 0.1193 0.1633
Trichomonas vaginalis heat shock protein, putative 0.0168 0.093 0.3291
Brugia malayi Pre-SET motif family protein 0.0036 0.0125 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0051
Brugia malayi hypothetical protein 0.0023 0.0046 0.0049
Schistosoma mansoni amine GPCR 0.0315 0.1835 0.2531
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0072 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0419 0.1433
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0043 0.0166 0.0198
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0315 0.1835 0.2546
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0065 0.03 0.0385
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0344
Schistosoma mansoni endoplasmin 0.021 0.1193 0.1633
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0315 0.1835 0.2531
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0315 0.1835 0.2531
Echinococcus multilocularis G-protein coupled receptor, putative 0.0315 0.1835 0.1835
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0043 0.0166 0.0217
Leishmania major phosphatidylinositol 3-kinase, putative 0.0115 0.0607 0.0833
Loa Loa (eye worm) hypothetical protein 0.025 0.1437 0.4063
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0022 0.0039 0.0051
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0072 0.0086
Brugia malayi sulfakinin receptor protein 0.0315 0.1835 0.2546
Schistosoma mansoni neuropeptide receptor 0.0315 0.1835 0.2531
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0122 0.0122
Onchocerca volvulus 0.0036 0.0125 0.0481
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0072 0.0066
Leishmania major dihydroorotate dehydrogenase 0.1187 0.7176 1
Leishmania major trypanothione reductase 0.0057 0.0254 0.0339
Giardia lamblia Grp94/Hsp90 0.0168 0.093 0.7752
Schistosoma mansoni opsin-like receptor 0.0315 0.1835 0.2531
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0254 0.032
Plasmodium falciparum endoplasmin, putative 0.0129 0.0694 0.0936
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0312 0.0312
Brugia malayi hypothetical protein 0.0315 0.1835 0.2546
Echinococcus granulosus muscleblind protein 0.0152 0.0838 0.0838
Leishmania major heat shock protein 83-1 0.021 0.1193 0.165
Echinococcus multilocularis chromobox protein 1 0.0084 0.0419 0.0419
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0046 0.0029
Echinococcus multilocularis neuropeptide receptor 0.0315 0.1835 0.1835
Leishmania major mitochondrial DNA topoisomerase II 0.0043 0.0166 0.0217
Echinococcus multilocularis neuropeptides capa receptor 0.0315 0.1835 0.1835
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0043 0.0166 0.0198
Schistosoma mansoni hypothetical protein 0.0315 0.1835 0.2531
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Treponema pallidum heat shock protein 90 0.0168 0.093 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1444 0.4081
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0039 0.004
Schistosoma mansoni amine GPCR 0.0315 0.1835 0.2531
Entamoeba histolytica DNA topoisomerase II, putative 0.0043 0.0166 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0072 0.0086
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0043 0.0166 0.0198
Trypanosoma cruzi heat shock protein 85, putative 0.021 0.1193 0.1633
Loa Loa (eye worm) hypothetical protein 0.0152 0.0838 0.2369
Brugia malayi cytochrome P450 0.002 0.0027 0.0023
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.002 0.0027 0.0003
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.002 0.0027 0.0003
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0315 0.1835 0.1835
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0315 0.1835 0.5188
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0022 0.0039 0.002
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Leishmania major phosphatidylinositol kinase, putative 0.0022 0.0039 0.004
Mycobacterium ulcerans heat shock protein 90 0.0168 0.093 0.1266
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0025 0.0025
Echinococcus granulosus neuropeptide Y receptor 0.0315 0.1835 0.1835
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0072 0.0066
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0145 0.0387
Schistosoma mansoni neuropeptide receptor 0.0315 0.1835 0.2531
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0469 0.2775 0.2775
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0072 0.0066
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0072 0.0072
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0022 0.0039 0.002
Giardia lamblia Pms1-like protein 0.0043 0.0166 0.121
Plasmodium falciparum DNA gyrase subunit B 0.0043 0.0166 0.0198
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0043 0.0166 0.0166
Echinococcus granulosus G protein coupled receptor 139 0.0315 0.1835 0.1835
Schistosoma mansoni cytochrome P450 0.002 0.0027 0.0003
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0046 0.0049
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0103 0.0292
Echinococcus granulosus neuropeptides capa receptor 0.0315 0.1835 0.1835
Toxoplasma gondii heat shock protein 75, putative 0.0086 0.0432 0.0569
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0196 0.0258
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0043 0.0166 0.0198
Echinococcus multilocularis allatostatin A receptor 0.0315 0.1835 0.1835
Echinococcus multilocularis heat shock protein 90 0.021 0.1193 0.1193
Brugia malayi hypothetical protein 0.0072 0.0347 0.047
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0702 0.0947
Trypanosoma cruzi heat shock protein 90, putative 0.0168 0.093 0.1266
Schistosoma mansoni heat shock protein 0.021 0.1193 0.1633
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0122 0.0156
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.1187 0.7176 1
Onchocerca volvulus 0.0315 0.1835 1
Echinococcus multilocularis GPCR, family 2 0.0047 0.0192 0.0192
Toxoplasma gondii Hsp90 domain-containing protein 0.0086 0.0432 0.0569
Trichomonas vaginalis DNA topoisomerase II, putative 0.0043 0.0166 0.0514
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0043 0.0166 0.0166
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0043 0.0166 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.03 0.1002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0196 0.0572
Trichomonas vaginalis heat shock protein, putative 0.021 0.1193 0.4245
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0196 0.0572
Loa Loa (eye worm) G-protein coupled receptor 0.0315 0.1835 0.5188
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0039 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0072 0.0086
Loa Loa (eye worm) hypothetical protein 0.005 0.021 0.0595
Schistosoma mansoni hypothetical protein 0.0165 0.0916 0.1247
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0205
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0022 0.0039 0.0039
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0022 0.0039 0.0039
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.1187 0.7176 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0029 0.0082 0.0207
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0056 0.0244 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0315 0.1835 0.1835
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0032 0.0007
Leishmania major cytochrome p450-like protein 0.002 0.0027 0.0023
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0315 0.1835 0.2531
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0027 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0153 0.0153
Echinococcus granulosus 7TM GPCR rhodopsin 0.0315 0.1835 0.1835
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0083 0.0081
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0115 0.0607 0.2076
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0043 0.0166 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0027
Echinococcus multilocularis Zinc finger, PHD finger 0.0022 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0205
Trichomonas vaginalis rotamase, putative 0.0039 0.0145 0.0437
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0022 0.0039 0.0039
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0082 0.0207
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0027 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Schistosoma mansoni coup transcription factor 0.0028 0.0072 0.0066
Schistosoma mansoni rotamase 0.004 0.0151 0.0176
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0083 0.0081
Echinococcus granulosus single minded 2 0.0039 0.0145 0.0145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0315 0.1835 0.2531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0145 0.0168
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0027 0.0003
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0043 0.0166 0.0198
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0022 0.0039 0.0051
Echinococcus granulosus tumor protein p63 0.0408 0.2404 0.2404
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0065 0.03 0.0385
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0043 0.0166 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0315 0.1835 0.1835
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0315 0.1835 0.1835
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0046 0.0029
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0029 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0315 0.1835 0.5188
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0022 0.0039 0.002
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.002 0.0027 0.0003
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0029 0.0082 0.01
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0192 0.0544
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0463 0.2743 0.3801
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0115 0.0607 0.0814
Brugia malayi Heterochromatin protein 1 0.0084 0.0419 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0039 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0607 0.2117
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.002 0.0027 0.0003
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0027 0.0003
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0043 0.0166 0.0198

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 5.9728 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 95.2834 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.