Detailed information for compound 1405642

Basic information

Technical information
  • TDR Targets ID: 1405642
  • Name: EU-0099738
  • MW: 316.395 | Formula: C18H24N2O3
  • H donors: 0 H acceptors: 3 LogP: 0.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)C(=O)CCN1C(=O)C2C(C1=O)C1CC2C=C1
  • InChi: 1S/C18H24N2O3/c1-11-4-7-19(8-5-11)14(21)6-9-20-17(22)15-12-2-3-13(10-12)16(15)18(20)23/h2-3,11-13,15-16H,4-10H2,1H3
  • InChiKey: UAFUHRNSFDJSIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_829100

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.008 0.051 0.0691
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.0331
Schistosoma mansoni ap endonuclease 0.008 0.051 0.0691
Mycobacterium ulcerans lipase LipD 0.0043 0.0244 0.0957
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0013 0.0024 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0064 0.0064
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.1025 0.7382 1
Echinococcus multilocularis Smad4 0.0017 0.0054 0.0054
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0189 0.3661
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0045 0.082
Schistosoma mansoni nocturnin 0.0016 0.0045 0.0061
Mycobacterium tuberculosis Conserved protein 0.0043 0.0244 0.0957
Schistosoma mansoni hypothetical protein 0.0114 0.0754 0.1021
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.1167 0.1581
Schistosoma mansoni aldehyde dehydrogenase 0.0241 0.168 0.2276
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0054 0.0054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0359 0.2539 0.3439
Brugia malayi Cytochrome P450 family protein 0.001 0.0004 0.0005
Echinococcus granulosus lamin 0.0026 0.0119 0.0119
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0037 0.0051
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0048 0.0178
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0037 0.0037
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0013 0.0024 0.0122
Echinococcus granulosus ferritin 0.0017 0.0048 0.0048
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0045 0.0045
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0039
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0013 0.0024 0.0081
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.1167 0.1581
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0045 0.082
Schistosoma mansoni survival motor neuron protein 0.0047 0.0269 0.0364
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0045 0.0045
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0013 0.0024 0.001
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0045 0.082
Leishmania major hypothetical protein, conserved 0.0016 0.0045 0.0248
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0241 0.168 1
Giardia lamblia Alcohol dehydrogenase 0.0013 0.0024 0.0472
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0016 0.0022
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0016 0.0022
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0356 0.2516 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0021 0.0007
Schistosoma mansoni cpg binding protein 0.0064 0.0394 0.0534
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0013 0.0024 0.0403
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0045 0.0045
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.1025 0.7382 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0244 0.0957
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1025 0.7382 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0114 0.0754 0.0754
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0203 0.0203
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0284 0.1994 0.2701
Schistosoma mansoni hypothetical protein 0.0047 0.0269 0.0364
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.003 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0203 0.0253
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0356 0.2516 0.3393
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0119 0.0162
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0114 0.0754 0.0754
Schistosoma mansoni lamin 0.0026 0.0119 0.0162
Schistosoma mansoni intermediate filament proteins 0.0026 0.0119 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0013 0.0024 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0244 0.4746
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0021 0.0105
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0016 0.0022
Mycobacterium tuberculosis Conserved protein 0.0043 0.0244 0.0957
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0013 0.0024 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0054 0.0073
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0058 0.0349 0.0472
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0013 0.0024 0.0081
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0016 0.0022
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0082 0.0111
Brugia malayi Smad1 0.0017 0.0054 0.0073
Loa Loa (eye worm) inositol-1 0.0036 0.0189 0.0256
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0048 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0189 0.3661
Loa Loa (eye worm) cytochrome P450 0.001 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0114 0.0754 0.1021
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0045 0.0061
Brugia malayi CXXC zinc finger family protein 0.0061 0.0369 0.05
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0045 0.082
Brugia malayi Fibroblast growth factor family protein 0.0058 0.0349 0.0472
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.0015
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0016 0.0022
Schistosoma mansoni ferritin light chain 0.0017 0.0048 0.0066
Echinococcus granulosus Smad4 0.0017 0.0054 0.0054
Onchocerca volvulus 0.0061 0.0369 0.3137
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.008 0.051 0.0691
Brugia malayi aldehyde dehydrogenase 0.0013 0.0024 0.0033
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0203 0.0253
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0045 0.082
Echinococcus multilocularis lamin 0.0026 0.0119 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.0015
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0013 0.0024 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0066 0.009
Echinococcus granulosus expressed protein 0.0012 0.0016 0.0016
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0054 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0114 0.0754 0.1021
Entamoeba histolytica exodeoxyribonuclease III, putative 0.008 0.051 0.067
Onchocerca volvulus Huntingtin homolog 0.0121 0.0805 0.7013
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Onchocerca volvulus Huntingtin homolog 0.0121 0.0805 0.7013
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0024 0.0033
Onchocerca volvulus 0.0167 0.1141 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0244 0.0957
Entamoeba histolytica hypothetical protein 0.0039 0.021 0.0263
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0045 0.082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.0331
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0241 0.168 0.168
Echinococcus multilocularis dUTP pyrophosphatase 0.1025 0.7382 0.7382
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0024 0.0033
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0045 0.082
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0203 0.0275
Schistosoma mansoni hypothetical protein 0.0245 0.1712 0.232
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0045 0.082
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0045 0.0045
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0013 0.0024 0.0033
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0013 0.0024 0.0024
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0013 0.0024 0.0024
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0013 0.0024 0.0033
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0013 0.0024 0.0081
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0356 0.2516 0.3386
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0045 0.0061
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0054 0.0054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.008 0.051 1
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0013 0.0024 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0244 0.4746
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0013 0.0024 0.0033
Leishmania major cytochrome p450-like protein 0.0019 0.0066 0.0374
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.0015
Entamoeba histolytica hypothetical protein 0.0356 0.2516 0.3393
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0162
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0114 0.0754 0.1021
Echinococcus granulosus lamin dm0 0.0026 0.0119 0.0119
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0066 0.0089
Echinococcus multilocularis cpg binding protein 0.0064 0.0394 0.0394
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0016 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0063 0.0085
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0203 0.0253
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0244 0.0957
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0013 0.0024 0.0033
Schistosoma mansoni hypothetical protein 0.0114 0.0754 0.1021
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0024 0.0403
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0013 0.0024 0.0024
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0024 0.0403
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0046 0.0001
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0045 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.021 0.021
Echinococcus granulosus smad 0.0017 0.0054 0.0054
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0189 0.1106
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.003 0.0019
Schistosoma mansoni hypothetical protein 0.0706 0.5062 0.6858
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0013 0.0024 0.0068
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0189 0.0224
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0369 0.05
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.1994 0.2701
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.1625 0.2201
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0045 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.1994 0.2701
Toxoplasma gondii aldehyde dehydrogenase 0.0241 0.168 0.2276
Brugia malayi intermediate filament protein 0.0026 0.0119 0.0162
Loa Loa (eye worm) RecQ helicase 0.0024 0.0103 0.0139
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0045 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.5116 0.5116
Schistosoma mansoni cript-related 0.0016 0.0045 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.008 0.051 0.2015
Brugia malayi MH1 domain containing protein 0.0017 0.0054 0.0073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0244 0.0331
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0013 0.0024 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0045 0.0039
Echinococcus granulosus bloom syndrome protein 0.0024 0.0103 0.0103
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0114 0.0754 0.0754
Onchocerca volvulus 0.0047 0.0269 0.2246
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0039
Echinococcus granulosus dUTP pyrophosphatase 0.1025 0.7382 0.7382
Loa Loa (eye worm) hypothetical protein 0.0121 0.0805 0.1091
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0016 0.0022
Schistosoma mansoni alpha-glucosidase 0.0147 0.0995 0.1347
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1601 0.1601
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0045 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0241 0.168 0.6674
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0024 0.0403
Brugia malayi hypothetical protein 0.0121 0.0805 0.1091
Schistosoma mansoni smad1 5 8 and 0.0017 0.0054 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.008 0.051 0.067
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0013 0.0024 0.001
Echinococcus granulosus intermediate filament protein 0.0026 0.0119 0.0119
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.000000000032947 0.00000000004463
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0045 0.0061
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0013 0.0024 0.0403
Brugia malayi MH1 domain containing protein 0.0017 0.0054 0.0073
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0045 0.0061
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0048 0.0178
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0013 0.0024 0.0081
Onchocerca volvulus 0.0016 0.0045 0.0256
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0189 0.0256
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.0015
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0244 0.0957
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0045 0.0248
Brugia malayi Inositol-1 0.0036 0.0189 0.0256
Schistosoma mansoni smad 0.0017 0.0054 0.0073
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.1167 0.1167
Brugia malayi MH2 domain containing protein 0.0254 0.1775 0.2405
Echinococcus multilocularis geminin 0.0706 0.5062 0.5062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.0015
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0045 0.0061
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0119 0.0162
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0203 0.0253
Schistosoma mansoni hypothetical protein 0.0039 0.021 0.0285
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0013 0.0024 0.0081
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0045 0.082
Brugia malayi Cytochrome P450 family protein 0.0048 0.0277 0.0375
Onchocerca volvulus 0.0099 0.0645 0.5587
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0037 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0114 0.0754 0.0754
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.008 0.051 0.051
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0013 0.0024 0.0081
Brugia malayi hypothetical protein 0.0012 0.0016 0.0022
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.008 0.051 1
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0043 0.0244 0.2024
Toxoplasma gondii ABC1 family protein 0.0043 0.0244 0.0331
Trichomonas vaginalis ferritin, putative 0.0017 0.0048 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0244 0.4746
Treponema pallidum hypothetical protein 0.0016 0.0045 0.0029
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0203 0.0275
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0203 0.0253
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0022
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0045 0.082
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0045 0.0039
Schistosoma mansoni synaptojanin 0.0016 0.0045 0.0061
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0024 0.0033
Trypanosoma brucei glucosidase, putative 0.0038 0.0203 0.3932
Echinococcus multilocularis expressed protein 0.0012 0.0016 0.0016
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1025 0.7382 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0048 0.0178
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0013 0.0024 0.001
Echinococcus granulosus cpg binding protein 0.0064 0.0394 0.0394
Echinococcus multilocularis expressed protein 0.0017 0.0048 0.0048
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0045 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0764 0.1035
Brugia malayi CCR4 0.0016 0.0045 0.0061
Echinococcus multilocularis GPCR, family 2 0.0114 0.0754 0.0754
Echinococcus multilocularis smad 0.0017 0.0054 0.0054
Mycobacterium leprae Probable lipase LipE 0.0043 0.0244 0.0957
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0244 0.0331
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0016 0.0022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0359 0.2539 0.3439
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0016 0.0022
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0045 0.0061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0241 0.168 0.168
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0203 0.0253
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0244 0.0957
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0045 0.0039
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0203 0.0253
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0244 0.0271
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0061
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0013 0.0024 0.0033
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.5735 0.5735
Schistosoma mansoni inositol monophosphatase 0.0036 0.0189 0.0256
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0045 0.082
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Schistosoma mansoni ap endonuclease 0.008 0.051 0.0691
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0045 0.082
Treponema pallidum exodeoxyribonuclease (exoA) 0.008 0.051 0.066
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0045 0.0039
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0013 0.0024 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0864 0.1171
Schistosoma mansoni cpg binding protein 0.0061 0.0369 0.05
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0066 0.025
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0013 0.0024 0.0024
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0189 0.0738
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0203 0.0253
Wolbachia endosymbiont of Brugia malayi dUTPase 0.1025 0.7382 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0066 0.1239
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Entamoeba histolytica hypothetical protein 0.1025 0.7382 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0021 0.0347
Schistosoma mansoni apoferritin-2 0.0017 0.0048 0.0066
Giardia lamblia hypothetical protein 0.0016 0.0045 0.0887
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0016 0.0022
Brugia malayi Aldehyde dehydrogenase protein 4 0.0013 0.0024 0.0033
Schistosoma mansoni cpg binding protein 0.0064 0.0394 0.0534
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0013 0.0024 0.0033
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0064 0.0087
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0021 0.0347
Toxoplasma gondii exonuclease III APE 0.008 0.051 0.0691
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0016 0.0016
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0016 0.0022
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0016 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0203 0.0253
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0189 0.0234
Brugia malayi MH2 domain containing protein 0.0017 0.0054 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.0015
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0013 0.0024 0.0081
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0066 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0203 0.0253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.1994 0.1994
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0022
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0189 0.3661
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0024 0.0122
Loa Loa (eye worm) Smad1 0.0017 0.0054 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0244 0.0309
Echinococcus granulosus synaptojanin 1 0.0016 0.0045 0.0045
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0103 0.0103
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.003 0.0019
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.1025 0.7382 1
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0024 0.0122
Onchocerca volvulus 0.0043 0.0244 0.2024
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0045 0.082
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0037 0.0037
Onchocerca volvulus 0.0026 0.0119 0.0914
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0024 0.0122
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0013 0.0024 0.0081
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.003 0.0522
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0048 0.0178
Leishmania major hypothetical protein, conserved 0.0043 0.0244 0.1433
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0244 0.0331
Onchocerca volvulus 0.0043 0.0244 0.2024
Schistosoma mansoni cytochrome P450 0.001 0.0004 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0114 0.0754 0.1021
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0203 0.1187
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0356 0.2516 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0045 0.0039
Mycobacterium ulcerans beta-lactamase 0.0043 0.0244 0.0957
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.003 0.0019
Schistosoma mansoni lamin 0.0026 0.0119 0.0162
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0045 0.082
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0045 0.0045
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0061
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0041
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0045 0.082
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0024 0.0403
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0241 0.168 0.6674
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0016 0.0022
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0013 0.0024 0.0403
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0013 0.0024 0.0024
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0013 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0359 0.2539 0.3439
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0045 0.0256
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.0015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0244 0.0957
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0203 0.0275
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0045 0.082
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0066 0.009
Leishmania major glycosyl hydrolase-like protein 0.0014 0.003 0.0158
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0013 0.0024 0.0403
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0013 0.0024 0.0403
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0045 0.0039
Echinococcus multilocularis lamin dm0 0.0026 0.0119 0.0119
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0045 0.082
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0669 0.4794 0.6486
Loa Loa (eye worm) hypothetical protein 0.0167 0.1141 0.1546
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.0331
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0024 0.0403
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.1775 0.2405
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0189 0.0234
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0244 0.0331
Schistosoma mansoni hypothetical protein 0.0114 0.0754 0.1021
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0244 0.0309
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.1994 0.2701
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0024 0.0403
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0189 0.0234
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0356 0.2516 1
Loa Loa (eye worm) hypothetical protein 0.023 0.1601 0.2169
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0359 0.2539 0.3439
Schistosoma mansoni ferritin light chain 0.0017 0.0048 0.0066
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1025 0.7382 1
Echinococcus multilocularis ferritin 0.0017 0.0048 0.0048
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0013 0.0024 0.0081
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.008 0.051 1
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0013 0.0024 0.0081
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0103 0.0139
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.0045 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.1994 0.1994
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.1994 0.1994
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0054 0.0054
Brugia malayi Fibroblast growth factor family protein 0.0058 0.0349 0.0472
Schistosoma mansoni Smad4 0.0017 0.0054 0.0073
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0061
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0016 0.0022
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0054 0.0054
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0016 0.0016
Echinococcus granulosus microtubule associated protein 2 0.0713 0.5116 0.5116
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0013 0.0024 0.0403
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0066 0.1239
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0045 0.0248
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0016 0.0022
Trichomonas vaginalis ap endonuclease, putative 0.008 0.051 0.067
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.008 0.051 0.2015
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0045 0.0061
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0045 0.082
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.1775 0.2405
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.008 0.051 0.066
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0162 0.0629
Brugia malayi beta-lactamase family protein 0.0043 0.0244 0.0331
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0004 0.0005
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0045 0.0039
Schistosoma mansoni alpha glucosidase 0.0038 0.0203 0.0275
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0024 0.0122
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0045 0.0045
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0016 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0244 0.0309
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.008 0.051 0.302
Schistosoma mansoni smad1 5 8 and 0.0017 0.0054 0.0073
Loa Loa (eye worm) beta-lactamase 0.0043 0.0244 0.0331
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0013 0.0024 0.0081
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.0045 0.0061
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Trichomonas vaginalis esterase, putative 0.0043 0.0244 0.0309
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0024 0.0403
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0244 0.0957
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0189 0.0189
Brugia malayi hypothetical protein 0.023 0.1601 0.2169
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0045 0.0039
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0244 0.0957
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0203 0.0253
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0016 0.0016
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0013 0.0024 0.0081
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0016 0.0016
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0244 0.0957
Schistosoma mansoni ferritin 0.0017 0.0048 0.0066
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0045 0.082
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0277 0.0375
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.0331
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1167 0.1167
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.5116 0.693
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0103 0.0117
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0013 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0245 0.1712 0.232
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0045 0.0061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0284 0.1994 0.2701
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.003 0.0019
Giardia lamblia Inositol 5-phosphatase 4 0.0016 0.0045 0.0887
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0005
Echinococcus multilocularis synaptojanin 1 0.0016 0.0045 0.0045
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0016 0.0022
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0045 0.0045
Brugia malayi G-protein alpha subunit 0.0012 0.0016 0.0022
Brugia malayi dUTP diphosphatase 0.1025 0.7382 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0114 0.0754 0.1021
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.0331
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0016 0.0016
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.003 0.0522
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1025 0.7382 1
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0024 0.0033
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0013 0.0024 0.0081
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0016 0.0022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Echinococcus multilocularis 0.001 0.0004 0.0004
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1025 0.7382 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0016 0.0022
Entamoeba histolytica hypothetical protein 0.0039 0.021 0.0263
Onchocerca volvulus 0.0026 0.0119 0.0914
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0244 0.0957
Mycobacterium ulcerans hypothetical protein 0.0043 0.0244 0.0957
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.051 0.0691
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Entamoeba histolytica hypothetical protein 0.0039 0.021 0.0263
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0244 0.0309
Brugia malayi cytochrome P450 0.001 0.0004 0.0005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.003 0.0019
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0013 0.0024 0.0033
Leishmania major hypothetical protein, conserved 0.0016 0.0045 0.0248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.1994 0.1994
Schistosoma mansoni hypothetical protein 0.0706 0.5062 0.6858
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0016 0.0022
Leishmania major hypothetical protein, conserved 0.0016 0.0045 0.0248
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0013 0.0024 0.0081
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0045 0.0061
Schistosoma mansoni alpha-glucosidase 0.0147 0.0995 0.1347
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0162 0.0629
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0048 0.0178
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0013 0.0024 0.0081
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0013 0.0024 0.0081
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.0331
Brugia malayi Cytochrome P450 family protein 0.0019 0.0066 0.009
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0024 0.0403
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0045 0.0039
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0045 0.0248
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0045 0.082
Brugia malayi follicle stimulating hormone receptor 0.0233 0.1625 0.2201
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0013 0.0024 0.0081
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.002 0.002
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0013 0.0024 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0022
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1025 0.7382 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0119 0.0162
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0045 0.082
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0024 0.0403
Mycobacterium tuberculosis Probable exported protein 0.0016 0.0045 0.0165
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0013 0.0024 0.0033
Schistosoma mansoni apoferritin-2 0.0017 0.0048 0.0066
Loa Loa (eye worm) hypothetical protein 0.0058 0.0349 0.0472
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0045 0.0039
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.003 0.0122
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0016 0.0022
Brugia malayi beta-lactamase family protein 0.0043 0.0244 0.0331
Entamoeba histolytica hypothetical protein 0.1025 0.7382 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0045 0.0061
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.008 0.051 0.051
Brugia malayi beta-lactamase 0.0043 0.0244 0.0331
Echinococcus granulosus GPCR family 2 0.0114 0.0754 0.0754
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.002 0.002
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0013 0.0024 0.0024
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.0045 0.0061
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.003 0.0041
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0356 0.2516 0.3393
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.003 0.0019
Onchocerca volvulus 0.0016 0.0045 0.0256
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0013 0.0024 0.0081
Schistosoma mansoni ferritin 0.0017 0.0048 0.0066
Brugia malayi hypothetical protein 0.0167 0.1141 0.1546
Schistosoma mansoni hypothetical protein 0.0864 0.6217 0.8421
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0021 0.0007
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1025 0.7382 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0016 0.0016
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0066 0.1239
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0033
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1025 0.7382 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0269 0.0364
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0045 0.0248
Entamoeba histolytica hypothetical protein 0.0669 0.4794 0.6486
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.003 0.0522
Brugia malayi MH2 domain containing protein 0.0017 0.0054 0.0073
Loa Loa (eye worm) hypothetical protein 0.0121 0.081 0.1097
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0033
Brugia malayi hypothetical protein 0.0039 0.021 0.0285
Loa Loa (eye worm) dUTP diphosphatase 0.1025 0.7382 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0061
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0023
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0045 0.082
Echinococcus granulosus expressed protein 0.0017 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0061
Schistosoma mansoni synaptojanin 0.0016 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0121 0.0805 0.1091
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0013 0.0024 0.0024
Schistosoma mansoni smad1 5 8 and 0.0017 0.0054 0.0073
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0013 0.0024 0.0033
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0013 0.0024 0.0081
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.003 0.0019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.051 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0203 0.3932
Trichomonas vaginalis helicase, putative 0.0014 0.0028 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0241 0.168 0.6674
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0189 0.0189
Giardia lamblia Hypothetical protein 0.0058 0.0349 0.684
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0054 0.0073
Echinococcus multilocularis musashi 0.0026 0.0119 0.0119
Echinococcus granulosus geminin 0.0706 0.5062 0.5062
Schistosoma mansoni ferritin 0.0017 0.0048 0.0066
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0103 0.0117
Echinococcus granulosus dnaJ subfamily B 0.0864 0.6217 0.6217
Schistosoma mansoni aldehyde dehydrogenase 0.0241 0.168 0.2276
Mycobacterium ulcerans aldehyde dehydrogenase 0.0013 0.0024 0.0081
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.003 0.0019
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.003 0.0041
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0045 0.0061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.021 0.021
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1025 0.7382 1
Entamoeba histolytica hypothetical protein 0.0039 0.021 0.0263
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0244 0.0309
Brugia malayi latrophilin 2 splice variant baaae 0.0245 0.1712 0.232
Schistosoma mansoni inositol monophosphatase 0.0036 0.0189 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0028 0.0015
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0045 0.0248
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0048 0.0033
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0013 0.0024 0.0033
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0016 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.021 0.0285
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.003 0.0019
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1167 0.1167
Brugia malayi Cytochrome P450 family protein 0.0019 0.0066 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0203 0.3932
Schistosoma mansoni ferritin 0.0017 0.0048 0.0066
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0024 0.0033
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0045 0.0045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0189 0.0234
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0024 0.0403
Loa Loa (eye worm) aldehyde dehydrogenase 0.0013 0.0024 0.0033
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.008 0.051 1
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0016 0.0022
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0024 0.0403
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0016 0.0022
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0244 0.0957
Echinococcus multilocularis dnaJ subfamily B 0.0864 0.6217 0.6217
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0064 0.0064
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0004 0.0004
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0356 0.2516 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0241 0.168 0.6674
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0022
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0045 0.0045
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1025 0.7382 1
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1601 0.1601
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0016 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1949 0.7742

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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