Detailed information for compound 1427409

Basic information

Technical information
  • TDR Targets ID: 1427409
  • Name: N'-(4-methoxy-3-nitrophenyl)sulfonyl-2-(2-met hyl-1,3-thiazol-4-yl)acetohydrazide
  • MW: 386.403 | Formula: C13H14N4O6S2
  • H donors: 2 H acceptors: 6 LogP: 1.26 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1[N+](=O)[O-])S(=O)(=O)NNC(=O)Cc1csc(n1)C
  • InChi: 1S/C13H14N4O6S2/c1-8-14-9(7-24-8)5-13(18)15-16-25(21,22)10-3-4-12(23-2)11(6-10)17(19)20/h3-4,6-7,16H,5H2,1-2H3,(H,15,18)
  • InChiKey: ITHLZJGVZKIDIF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N'-(4-methoxy-3-nitro-phenyl)sulfonyl-2-(2-methylthiazol-4-yl)acetohydrazide
  • N'-(4-methoxy-3-nitrophenyl)sulfonyl-2-(2-methyl-4-thiazolyl)acetohydrazide
  • N'-(4-methoxy-3-nitro-phenyl)sulfonyl-2-(2-methyl-1,3-thiazol-4-yl)ethanehydrazide
  • T5521535

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 6, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Brugia malayi Cell death protein 3 precursor caspase 6, apoptosis-related cysteine peptidase 293 aa 270 aa 34.4 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0597 0.0597
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0046
Mycobacterium ulcerans short-chain dehydrogenase 0.0007 0.0037 0.0305
Plasmodium vivax CDK-related protein kinase 6, putative 0.0431 1 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis dullard protein, putative 0.0015 0.0218 0.0968
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0582 0.0649
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Schistosoma mansoni hypothetical protein 0.0205 0.4679 0.5219
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.031 0.0345
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0597 0.844
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0119 0.2978
Echinococcus granulosus inhibitor of apoptosis protein 0.011 0.2448 0.273
Schistosoma mansoni cpg binding protein 0.0029 0.0541 0.0603
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0018 0.0297 0.1318
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.009 0.0101
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0552 0.0615
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0399 0.0445
Giardia lamblia Short-chain dehydrogenase, putative 0.0007 0.0037 0.0644
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0018 0.0297 0.0331
Mycobacterium leprae Probable oxidoreductase 0.0007 0.0037 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma cruzi metacaspase, putative 0.0032 0.062 0.8762
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Leishmania major short chain dehydrogenase, putative 0.0007 0.0037 0.0305
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0007 0.0037 0.053
Echinococcus granulosus hypothetical protein 0.0007 0.0037 0.0042
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.009 0.0101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus granulosus steroid dehydrogenase 0.0007 0.0037 0.0042
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.031 0.1265
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.062 0.0937
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0018 0.0297 0.0331
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0606 0.8572
Brugia malayi oxidoreductase 0.0007 0.0037 0.0153
Loa Loa (eye worm) hypothetical protein 0.003 0.0582 0.2378
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0063 0.0259
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0201 0.2848
Schistosoma mansoni caspase-3 (C14 family) 0.0032 0.062 0.0691
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0007 0.0037 0.0166
Mycobacterium tuberculosis Probable oxidoreductase 0.0007 0.0037 0.0188
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0188
Leishmania major quinonoid dihydropteridine reductase 0.0007 0.0037 0.0305
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0386 0.9679
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0018 0.0297 0.0331
Echinococcus multilocularis carbonyl reductase 1 0.0007 0.0037 0.0042
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1228 0.5016
Leishmania major hypothetical protein, conserved 0.0007 0.0037 0.0305
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0007 0.0037 0.053
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0007 0.0037 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Schistosoma mansoni coup transcription factor 0.001 0.009 0.0101
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0007 0.0037 0.0188
Onchocerca volvulus 0.0014 0.0201 0.068
Onchocerca volvulus 0.0014 0.0201 0.068
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0582 0.0649
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0112 0.2489 0.2777
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.001 0.0105 0.0467
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0046
Echinococcus multilocularis RUN 0.0019 0.0304 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0606 0.269
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.009 0.037
Echinococcus multilocularis conserved hypothetical protein 0.0007 0.0037 0.0042
Echinococcus multilocularis carbonyl reductase 1 0.0007 0.0037 0.0042
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0007 0.0037 0.0305
Brugia malayi Thioredoxin reductase 0.0036 0.0707 0.2889
Leishmania major glucose transporter, lmgt1 0.0031 0.0606 0.4938
Leishmania major quinonoid dihydropteridine reductase 0.0007 0.0037 0.0305
Mycobacterium ulcerans short-chain dehydrogenase 0.0007 0.0037 0.0305
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0597 0.0597
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0157 0.2224
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.031 0.0345
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0119 0.0967
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0051 0.1056 0.4314
Brugia malayi DNA polymerase family B containing protein 0.0018 0.0297 0.1214
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0597 0.2438
Mycobacterium ulcerans carveol-like dehydrogenase 0.0007 0.0037 0.0305
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.009 0.0101
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0386 0.193
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.009 0.0101
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0007 0.0037 0.0628
Schistosoma mansoni protein kinase 0.0031 0.0597 0.0666
Entamoeba histolytica protein kinase, putative 0.0031 0.0597 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.009 0.037
Onchocerca volvulus 0.0014 0.0201 0.068
Echinococcus granulosus solute carrier family 22 0.0014 0.0201 0.0225
Schistosoma mansoni nuclear hormone receptor 0.001 0.009 0.0101
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0007 0.0037 0.0188
Echinococcus granulosus hypothetical protein 0.0007 0.0037 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0597 0.0666
Plasmodium vivax DNA polymerase alpha, putative 0.0018 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.037
Schistosoma mansoni protein kinase 0.0031 0.0597 0.0666
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.062 0.0691
Brugia malayi hypothetical protein 0.0007 0.0037 0.0153
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0597 0.0597
Loa Loa (eye worm) sugar transporter 0.0102 0.2253 0.9207
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.009 0.037
Leishmania major quinonoid dihydropteridine reductase 0.0007 0.0037 0.0305
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0007 0.0037 0.053
Trypanosoma cruzi metacaspase, putative 0.0032 0.062 0.8762
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0201 0.522
Loa Loa (eye worm) hypothetical protein 0.0015 0.0218 0.0891
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0582 0.0649
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0007 0.0037 0.0188
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.031 0.0345
Echinococcus multilocularis FTZ F1 alpha 0.001 0.009 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0606 0.269
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Brugia malayi Dehydrogenases, short chain protein 30 0.0007 0.0037 0.0153
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0597 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0079 0.1715 0.7008
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.009 0.022
Echinococcus granulosus carbonyl reductase 1 0.0007 0.0037 0.0042
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Trypanosoma cruzi hexose transporter 0.0031 0.0606 0.8572
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0218 0.0968
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.031 0.0468
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0157 0.2224
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.0666
Toxoplasma gondii DNA polymerase 0.0018 0.0297 0.0449
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0018 0.0297 0.0449
Brugia malayi Sugar transporter family protein 0.0014 0.0201 0.0823
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0018 0.0297 0.4201
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0218 0.0891
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.031 0.031
Toxoplasma gondii sugar transporter ST3 0.0014 0.0201 0.0305
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0701 0.5708
Echinococcus multilocularis tumor protein p63 0.032 0.7382 0.8235
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.031 0.0345
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.0666
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0188
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.009 0.0101
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0007 0.0037 0.053
Brugia malayi Cell death protein 3 precursor 0.0032 0.062 0.2531
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Echinococcus multilocularis geminin 0.0205 0.4679 0.5219
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0007 0.0037 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0063 0.0071
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0012 0.0157 0.0175
Onchocerca volvulus 0.0014 0.0201 0.068
Leishmania major oxidoreductase-like protein 0.0007 0.0037 0.0305
Trypanosoma brucei metacaspase MCA3 0.0032 0.062 0.8762
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Giardia lamblia Hypothetical protein 0.0007 0.0037 0.0644
Entamoeba histolytica hypothetical protein 0.0007 0.0037 0.0628
Mycobacterium ulcerans ketoacyl reductase 0.0007 0.0037 0.0305
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0018 0.0297 0.1077
Plasmodium falciparum steroid dehydrogenase, putative 0.0007 0.0037 0.0037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.1216 0.1357
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0018 0.0297 0.0331
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.009 0.0101
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0012 0.0157 0.1281
Mycobacterium ulcerans oxidoreductase 0.0007 0.0037 0.0305
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0007 0.0037 0.053
Onchocerca volvulus 0.0014 0.0201 0.068
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Leishmania major quinonoid dihydropteridine reductase 0.0007 0.0037 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.009 0.037
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Loa Loa (eye worm) hypothetical protein 0.0008 0.0058 0.0235
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.0218 0.3748
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0007 0.0037 0.0188
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.1228 0.614
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0018 0.0297 0.0331
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0399 0.1769
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0012 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.009 0.037
Echinococcus granulosus caspase 0.0032 0.062 0.0691
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0201 0.1007
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8572
Echinococcus multilocularis steroid dehydrogenase 0.0007 0.0037 0.0042
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0007 0.0037 0.0166
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1228 1
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0018 0.0297 0.4201
Echinococcus granulosus dnaJ subfamily B 0.0387 0.8965 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0091 0.1999 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8572
Brugia malayi Sugar transporter family protein 0.0014 0.0201 0.0823
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0007 0.0037 0.0057
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.009 0.0101
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.009 0.0101
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0018 0.0297 0.1077
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0157 0.2224
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0018 0.0297 0.0331
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.008 0.0326
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0386 0.3143
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0014 0.0201 0.0225
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0386 0.193
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0007 0.0037 0.0042
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1228 0.137
Giardia lamblia DNA polymerase alpha subunit A 0.0008 0.0058 0.099
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Brugia malayi hypothetical protein 0.0014 0.0201 0.0823
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium ulcerans short-chain dehydrogenase 0.0007 0.0037 0.0305
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0082 0.1785 0.8929
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0012 0.0157 0.0157
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2253 0.2514
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0007 0.0037 0.0166
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0007 0.0037 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Mycobacterium ulcerans short-chain type oxidoreductase 0.0007 0.0037 0.0305
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0007 0.0037 0.0188
Plasmodium vivax metacaspase 1, putative 0.0032 0.062 0.062
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0018 0.0297 0.1214
Giardia lamblia Sugar-proton symporter 0.0014 0.0201 0.346
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0032 0.062 0.0691
Brugia malayi dehydrogenases, short chain protein 2 0.0007 0.0037 0.0153
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0012 0.0157 0.1281
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.009 0.0101
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0018 0.0297 0.0331
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2253 0.2514
Schistosoma mansoni retinal dehydrogenase 0.0007 0.0037 0.0042
Entamoeba histolytica hypothetical protein 0.0023 0.0399 0.6679
Toxoplasma gondii oxidoreductase, putative 0.0007 0.0037 0.0057
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0007 0.0037 0.0188
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8572
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0082 0.1785 0.8929
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.062 0.275
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0606 0.269
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0157 0.1281
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0218 0.0968
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0012 0.0157 0.2224
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Leishmania major quinonoid dihydropteridine reductase 0.0007 0.0037 0.0305
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0386 0.0386
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Giardia lamblia NADH oxidase lateral transfer candidate 0.0012 0.0157 0.2702
Giardia lamblia Reductase, putative 0.0007 0.0037 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0597 0.0597
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0399 0.5637
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0018 0.0297 0.4201
Entamoeba histolytica hypothetical protein, conserved 0.0007 0.0037 0.0628
Brugia malayi nuclear receptor NHR-88 0.001 0.009 0.037
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.031 0.4377
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0399 0.0399
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0007 0.0037 0.053
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0025 0.0448 0.1829
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0399 0.5637
Schistosoma mansoni thyroid hormone receptor 0.001 0.009 0.0101
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.009 0.022
Schistosoma mansoni thyroid hormone receptor 0.001 0.009 0.0101
Plasmodium vivax sugar transporter, putative 0.0014 0.0201 0.0201
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0188
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0606 0.4938
Onchocerca volvulus 0.0019 0.0304 0.1107
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.031 0.031
Leishmania major hypothetical protein, conserved 0.0014 0.0201 0.164
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0201 0.0225
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0157 0.2224
Plasmodium falciparum hexose transporter 0.0102 0.2253 0.2253
Schistosoma mansoni rab6-interacting 0.0019 0.0304 0.0339
Trypanosoma brucei trypanothione reductase 0.0036 0.0707 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0007 0.0037 0.0188
Echinococcus granulosus General substrate transporter 0.0087 0.1918 0.2139
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0597 0.0903
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0597 0.2438
Trypanosoma brucei metacaspase 5, putative 0.0032 0.062 0.8762
Trypanosoma cruzi metacaspase, putative 0.0032 0.062 0.8762
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Echinococcus multilocularis retinol dehydrogenase 11 0.0007 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.0218 0.0218
Leishmania major trypanothione reductase 0.0036 0.0707 0.576
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.037
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0007 0.0037 0.0042
Trichomonas vaginalis dullard protein, putative 0.0015 0.0218 0.0968
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0012 0.0157 0.0238
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0701 0.9909
Echinococcus granulosus caspase 8 0.0032 0.062 0.0691
Onchocerca volvulus 0.0014 0.0201 0.068
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Echinococcus granulosus retinol dehydrogenase 11 0.0007 0.0037 0.0042
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0007 0.0037 0.053
Plasmodium vivax glutathione reductase, putative 0.0036 0.0707 0.0707
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0007 0.0037 0.0188
Treponema pallidum NADH oxidase 0.0012 0.0157 0.4076
Brugia malayi hypothetical protein 0.0019 0.0304 0.1243
Echinococcus multilocularis solute carrier family 22 0.0014 0.0201 0.0225
Trichomonas vaginalis dullard protein, putative 0.0015 0.0218 0.0968
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0007 0.0037 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.062 0.275
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Echinococcus multilocularis solute carrier family 22 0.0014 0.0201 0.0225
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.001 0.0046
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.009 0.0101
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0218 0.0243
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.001 0.0105 0.0105
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0201 0.0201
Brugia malayi hypothetical protein 0.0014 0.0201 0.0823
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Entamoeba histolytica hypothetical protein, conserved 0.0007 0.0037 0.0628
Brugia malayi Dehydrogenases, short chain protein 2 0.0007 0.0037 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.031 0.0345
Echinococcus granulosus carbonyl reductase 1 0.0007 0.0037 0.0042
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0218 0.3084
Brugia malayi Sugar transporter family protein 0.0102 0.2253 0.9207
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.1216 0.9908
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0582 0.2583
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Schistosoma mansoni sugar transporter 0.0014 0.0201 0.0225
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0157 0.2224
Plasmodium falciparum thioredoxin reductase 0.0012 0.0157 0.0157
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0188
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0157 0.2224
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Echinococcus multilocularis carbonyl reductase 1 0.0007 0.0037 0.0042
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0024 0.0027
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0701 0.0701
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0304 0.0339
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0037 0.053
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0606 0.269
Echinococcus multilocularis caspase 8 0.0032 0.062 0.0691
Trypanosoma brucei metacaspase 0.0032 0.062 0.8762
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0201 0.164
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Schistosoma mansoni protein kinase 0.0031 0.0597 0.0666
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0007 0.0037 0.0628
Loa Loa (eye worm) hypothetical protein 0.0023 0.0399 0.1629
Brugia malayi nuclear hormone receptor 0.001 0.009 0.037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0597 0.0666
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0201 0.164
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0597 0.2648
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0386 0.0584
Loa Loa (eye worm) sugar transporter 0.0014 0.0201 0.0823
Plasmodium falciparum glutathione reductase 0.0012 0.0157 0.0157
Schistosoma mansoni glucose transport protein 0.0102 0.2253 0.2514
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0018 0.0297 0.4201
Brugia malayi CXXC zinc finger family protein 0.0027 0.0505 0.2061
Echinococcus multilocularis 0.0015 0.0218 0.0243
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3724 0.3724
Loa Loa (eye worm) hypothetical protein 0.0018 0.0297 0.1214
Toxoplasma gondii NADPH-glutathione reductase 0.0012 0.0157 0.0238
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0007 0.0037 0.053
Leishmania major hypothetical protein, conserved 0.0007 0.0037 0.0305
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0007 0.0037 0.0188
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0007 0.0037 0.0153
Mycobacterium tuberculosis Probable oxidoreductase 0.0007 0.0037 0.0188
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0606 0.8572
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Brugia malayi major facilitator superfamily protein 0.0014 0.0201 0.0823
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0007 0.0037 0.0057
Schistosoma mansoni loxhd1 0.0019 0.0304 0.0339
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0201 0.2848
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0018 0.0297 0.0297
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0201 0.164
Brugia malayi hypothetical protein 0.0019 0.0304 0.1243
Echinococcus multilocularis L aminoadipate semialdehyde 0.0079 0.1715 0.1913
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2253 0.2514
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0318 0.1592
Echinococcus granulosus geminin 0.0205 0.4679 0.5219
Schistosoma mansoni inhibitor of apoptosis protein 0.011 0.2448 0.273
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.062 0.0691
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0157 0.4076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0214 0.0873
Brugia malayi Doublecortin family protein 0.0019 0.0304 0.1243
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0008 0.0058 0.0965
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0037 0.053
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0032 0.062 0.0691
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.009 0.0101
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0582 0.0649
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3724 0.3724
Loa Loa (eye worm) hypothetical protein 0.0079 0.1715 0.7008
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0304 0.0339
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0037 0.053
Trichomonas vaginalis glutathione reductase, putative 0.0012 0.0157 0.0698
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Brugia malayi glutathione reductase 0.0036 0.0707 0.2889
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0007 0.0037 0.0166
Toxoplasma gondii sugar transporter ST2 0.0014 0.0201 0.0305
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0007 0.0037 0.053
Mycobacterium tuberculosis Probable reductase 0.0082 0.1785 0.8929
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0018 0.0297 0.242
Onchocerca volvulus 0.0014 0.0201 0.068
Leishmania major hypothetical protein, conserved 0.0015 0.0218 0.1777
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.0218 0.0243
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0399 0.0445
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0007 0.0037 0.0166
Plasmodium falciparum metacaspase 1 0.0032 0.062 0.062
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3724 0.5632
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0218 0.0243
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0032 0.062 0.2531
Mycobacterium tuberculosis Possible oxidoreductase 0.0007 0.0037 0.0188
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0701 0.9909
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0012 0.0157 0.0643
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0018 0.0297 0.0297
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.009 0.0101
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0018 0.0297 0.242
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0018 0.0297 0.4978
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0386 1
Onchocerca volvulus 0.011 0.2448 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0063 0.0071
Schistosoma mansoni hypothetical protein 0.011 0.2448 0.273
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0007 0.0037 0.053
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.016 0.0653
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0007 0.0037 0.053
Loa Loa (eye worm) glutathione reductase 0.0036 0.0707 0.2889
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0007 0.0037 0.0972
Toxoplasma gondii carbonyl reductase 1, putative 0.0007 0.0037 0.0057
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0399 0.0445
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8572
Brugia malayi major facilitator superfamily protein 0.0014 0.0201 0.0823
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Plasmodium vivax steroid dehydrogenase, putative 0.0007 0.0037 0.0037
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0386 1
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0037 0.0037
Brugia malayi Steroid receptor seven-up type 2 0.001 0.009 0.037
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0007 0.0037 0.0042
Schistosoma mansoni sugar transporter 0.0014 0.0201 0.0225
Plasmodium vivax thioredoxin reductase, putative 0.0036 0.0707 0.0707
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.1216 0.1357
Echinococcus granulosus retinol dehydrogenase 11 0.0007 0.0037 0.0042
Echinococcus granulosus solute carrier family 22 0.0014 0.0201 0.0225
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0701 0.106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.009 0.037
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.0218 0.0243
Onchocerca volvulus 0.001 0.009 0.022
Brugia malayi DNA polymerase alpha catalytic subunit 0.0018 0.0297 0.1214
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Onchocerca volvulus 0.0047 0.0966 0.3852
Schistosoma mansoni sugar transporter 0.0014 0.0201 0.0225
Trypanosoma cruzi hexose transporter, putative 0.0017 0.027 0.3825
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0333 0.1477
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Leishmania major glucose transporter, lmgt3 0.0031 0.0606 0.4938
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0018 0.0297 0.1318
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Mycobacterium ulcerans oxidoreductase 0.0007 0.0037 0.0305
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8572
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0201 0.0894
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.011 0.2448 0.273
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0606 0.269
Leishmania major short chain dehydrogenase, putative 0.0007 0.0037 0.0305
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.008 0.0326
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0582 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0218 0.0218
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0082 0.1785 0.8929
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0046
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0007 0.0037 0.053
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0007 0.0037 0.0153
Trichomonas vaginalis helicase, putative 0.0006 0.001 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.009 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Mycobacterium ulcerans dehydrogenase 0.0007 0.0037 0.0305
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0008 0.0058 0.0235
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0399 0.1994
Loa Loa (eye worm) hypothetical protein 0.0031 0.0597 0.2438
Schistosoma mansoni hypothetical protein 0.0205 0.4679 0.5219
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0018 0.0297 0.4201
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0007 0.0037 0.0166
Toxoplasma gondii DNA polymerase family B protein 0.0008 0.0058 0.0087
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0012 0.0157 0.0175
Trypanosoma brucei short-chain dehydrogenase, putative 0.0007 0.0037 0.053
Echinococcus multilocularis thioredoxin glutathione reductase 0.0036 0.0718 0.0801
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0007 0.0037 0.0042
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.009 0.037
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0218 0.0968
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0012 0.0157 0.0787
Trypanosoma cruzi short chain dehydrogenase, putative 0.0007 0.0037 0.053
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.009 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0032 0.062 0.062
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0018 0.0297 0.0331
Brugia malayi DNA polymerase delta catalytic subunit 0.0018 0.0297 0.1214
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0007 0.0037 0.053
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0007 0.0037 0.0057
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0057
Echinococcus multilocularis carbonyl reductase 1 0.0007 0.0037 0.0042
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.0218 0.0243
Onchocerca volvulus 0.0014 0.0201 0.068
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0007 0.0037 0.0166
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0597 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Echinococcus granulosus tumor protein p63 0.032 0.7382 0.8235
Leishmania major short chain dehydrogenase-like protein 0.0007 0.0037 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis DNA polymerase II, putative 0.0018 0.0297 0.1318
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0082 0.1785 0.8929
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.0218 0.033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0157 0.2224
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0018 0.0297 0.0297
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0552 0.0615
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0707 1
Echinococcus multilocularis retinol dehydrogenase 13 0.0007 0.0037 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.1216 0.9908
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Onchocerca volvulus Bile acid receptor homolog 0.001 0.009 0.022
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0304 0.0304
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0304 0.0304
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0007 0.0037 0.0305
Loa Loa (eye worm) hypothetical protein 0.0032 0.062 0.2531
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0007 0.0037 0.0153
Brugia malayi hypothetical protein 0.0014 0.0201 0.0823
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.031 0.0345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.009 0.037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.009 0.037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.009 0.0101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0046
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0008 0.0058 0.0058
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0015 0.0218 0.3655
Trichomonas vaginalis mercuric reductase, putative 0.0012 0.0157 0.0698
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.1216 0.9908
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0036 0.0707 0.3537
Echinococcus multilocularis retinol dehydrogenase 11 0.0007 0.0037 0.0042
Schistosoma mansoni cellular tumor antigen P53 0.0047 0.0966 0.1077
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0597 0.2438
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.011 0.2448 1
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0119 0.3076
Entamoeba histolytica hypothetical protein 0.0022 0.0386 0.6465
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0188
Echinococcus granulosus cpg binding protein 0.0029 0.0541 0.0603
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.1216 0.1357
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0037 0.053
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0007 0.0037 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.062 0.275
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.011 0.2448 0.273
Brugia malayi dehydrogenases, short chain protein 9 0.0007 0.0037 0.0153
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0304 0.0339
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0024 0.0027
Toxoplasma gondii sugar transporter ST1 0.0014 0.0201 0.0305
Leishmania major quinonoid dihydropteridine reductase 0.0007 0.0037 0.0305
Mycobacterium tuberculosis Probable dehydrogenase 0.0082 0.1785 0.8929
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0091 0.1999 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.031 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.009 0.037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0018 0.0297 0.4201
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0018 0.0297 0.0331
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0007 0.0037 0.0166
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.009 0.0101
Leishmania major hypothetical protein, conserved 0.0007 0.0037 0.0305
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Entamoeba histolytica protein kinase, putative 0.0031 0.0597 1
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0701 0.0701
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0018 0.0297 0.0331
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.009 0.0101
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0008 0.0058 0.0814
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.1076 0.1627
Echinococcus granulosus thioredoxin glutathione reductase 0.0036 0.0718 0.0801
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0304 0.0339
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0218 0.0968
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.0666
Onchocerca volvulus 0.0014 0.0201 0.068
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Echinococcus multilocularis solute carrier family 22 0.0014 0.0201 0.0225
Trypanosoma brucei short-chain dehydrogenase, putative 0.0007 0.0037 0.053
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0007 0.0037 0.0166
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0201 0.2848
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.037
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.062 0.0691
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.062 0.8762
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Echinococcus granulosus solute carrier family 22 0.0014 0.0201 0.0225
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.009 0.0101
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0012 0.0157 0.2224
Echinococcus multilocularis steroid dehydrogenase 0.0007 0.0037 0.0042
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0007 0.0037 0.053
Echinococcus multilocularis inhibitor of apoptosis protein 0.011 0.2448 0.273
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0007 0.0037 0.0042
Trypanosoma brucei metacaspase MCA2 0.0032 0.062 0.8762
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0606 0.269
Leishmania major 3-keto-dihydrosphingosine reductase 0.0007 0.0037 0.0305
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Leishmania major short chain dehydrogenase/reductase, putative 0.0007 0.0037 0.0305
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0018 0.0297 0.4201
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.009 0.037
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0007 0.0037 0.0188
Mycobacterium tuberculosis Probable oxidoreductase 0.0007 0.0037 0.0188
Loa Loa (eye worm) hypothetical protein 0.011 0.2448 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.1228 1
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0399 0.1629
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0012 0.0157 0.0157
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0057
Echinococcus granulosus baculoviral IAP repeat containing protein 0.011 0.2448 0.273
Onchocerca volvulus 0.0014 0.0201 0.068
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.062 0.0937
Schistosoma mansoni polycystin 1-related 0.0019 0.0304 0.0339
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0157 0.4076
Brugia malayi Cam kinase protein 1 0.0031 0.0597 0.2438
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Schistosoma mansoni glucose transport protein 0.0102 0.2253 0.2514
Trypanosoma cruzi trypanothione reductase, putative 0.0012 0.0157 0.2224
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0201 0.0823
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0037 0.053
Trypanosoma brucei glucose transporter 1E 0.0031 0.0606 0.8572
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Leishmania major hypothetical protein, conserved 0.0007 0.0037 0.0305
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0505 0.2061
Schistosoma mansoni hypothetical protein 0.0387 0.8965 1
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0008 0.0058 0.0965
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0007 0.0037 0.0188
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0201 0.164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.009 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.009 0.037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Mycobacterium tuberculosis Probable oxidoreductase 0.0007 0.0037 0.0188
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Schistosoma mansoni sugar transporter 0.0014 0.0201 0.0225
Brugia malayi Isocitrate dehydrogenase 0.0019 0.031 0.1265
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0008 0.0058 0.0058
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0018 0.0297 0.1318
Echinococcus multilocularis transient receptor potential cation channel 0.0007 0.0037 0.0042
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0386 0.0386
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0597 0.0597
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0007 0.0037 0.0188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.009 0.0101
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.009 0.037
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0012 0.0157 0.1281
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0012 0.0157 0.0175
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.037
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0018 0.0297 0.5104
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.1216 0.1357
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2253 0.3408
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0386 0.3143
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0112 0.2489 0.2777
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0007 0.0037 0.0166
Trypanosoma brucei Metacaspase-4 0.0032 0.062 0.8762
Onchocerca volvulus DNA polymerase homolog 0.0018 0.0297 0.1077
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.009 0.0101
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0597 0.0597
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.009 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.009 0.037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Echinococcus granulosus WW domain containing oxidoreductase 0.0007 0.0037 0.0042
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0018 0.0297 0.0297
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.031 0.4377
Trichomonas vaginalis steroid dehydrogenase, putative 0.0007 0.0037 0.0166
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0007 0.0037 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2253 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0057
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Trypanosoma brucei short-chain dehydrogenase, putative 0.0007 0.0037 0.053
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.031 0.4377
Onchocerca volvulus 0.0014 0.0201 0.068
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0007 0.0037 0.0188
Leishmania major glucose transporter, lmgt2 0.0031 0.0606 0.4938
Mycobacterium ulcerans short-chain dehydrogenase 0.0007 0.0037 0.0305
Leishmania major pteridine reductase 1 0.0007 0.0037 0.0305
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0201 0.0225
Trypanosoma brucei short-chain dehydrogenase, putative 0.0007 0.0037 0.053
Loa Loa (eye worm) steroid hormone receptor 0.001 0.009 0.037
Schistosoma mansoni hypothetical protein 0.0015 0.0214 0.0238
Loa Loa (eye worm) hypothetical protein 0.0047 0.0966 0.3946
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0386 0.3143
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0201 0.1007
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.062 0.8762
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.1221 0.1362
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2253 0.2514
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0606 0.8572
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0304 0.0339
Schistosoma mansoni cpg binding protein 0.0027 0.0505 0.0563
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0582 0.2378
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0057
Schistosoma mansoni glucose transport protein 0.0102 0.2253 0.2514
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.009 0.037
Echinococcus multilocularis solute carrier family 22 0.0014 0.0201 0.0225
Schistosoma mansoni carbonyl reductase 0.0007 0.0037 0.0042
Echinococcus granulosus caspase 2 0.0032 0.062 0.0691
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0318 0.1592
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma brucei short-chain dehydrogenase, putative 0.0007 0.0037 0.053
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0007 0.0037 0.0037
Trypanosoma cruzi metacaspase, putative 0.0032 0.062 0.8762
Brugia malayi isocitrate dehydrogenase 0.0019 0.031 0.1265
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0386 0.5456
Mycobacterium ulcerans sugar transporter 0.0014 0.0201 0.164
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8572
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.037
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0012 0.0157 0.1281
Schistosoma mansoni glucose transporter 0.0014 0.0201 0.0225
Schistosoma mansoni carbonyl reductase 0.0007 0.0037 0.0042
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0007 0.0037 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0399 0.0445
Mycobacterium tuberculosis Probable oxidoreductase 0.0091 0.1999 1
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0007 0.0037 0.053
Echinococcus granulosus carbonyl reductase 1 0.0007 0.0037 0.0042
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0201 0.0823
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0597 0.0597
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0582 0.2911
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0082 0.1785 0.8929
Loa Loa (eye worm) dehydrogenase 0.0007 0.0037 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0007 0.0037 0.053
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0386 0.0584
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0008 0.0058 0.0469
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0018 0.0297 0.242
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.009 0.0101
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.011 0.2448 1
Loa Loa (eye worm) dehydrogenase 0.0007 0.0037 0.0153
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0046
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0091 0.1999 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Brugia malayi Retinol dehydrogenase 12 0.0007 0.0037 0.0153
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.1216 0.6084
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0597 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.062 0.275
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0018 0.0297 0.1077
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.062 0.2531
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0399 0.3247
Mycobacterium ulcerans ketoacyl reductase 0.0007 0.0037 0.0305
Trypanosoma brucei glucose transporter 2A 0.0031 0.0606 0.8572
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0201 0.0305
Toxoplasma gondii oxidoreductase, putative 0.0007 0.0037 0.0057
Mycobacterium ulcerans dehydrogenase/reductase 0.0007 0.0037 0.0305
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.031 0.0468
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0701 0.9909
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.009 0.037
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0218 0.0218
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0201 0.0894
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0024 0.0027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.009 0.0101
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.031 0.1548
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0201 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.009 0.037
Mycobacterium tuberculosis Probable oxidoreductase 0.0007 0.0037 0.0188
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0304 0.1243
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Trypanosoma cruzi short chain dehydrogenase, putative 0.0007 0.0037 0.053
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0606 0.269
Leishmania major hypothetical protein, conserved 0.0007 0.0037 0.0305
Onchocerca volvulus 0.0027 0.0505 0.1938
Loa Loa (eye worm) hypothetical protein 0.001 0.0105 0.043
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0007 0.0037 0.053
Echinococcus granulosus oxidoreductase 0.0007 0.0037 0.0042
Loa Loa (eye worm) oxidoreductase 0.0007 0.0037 0.0153
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0201 0.0823
Toxoplasma gondii DNA polymerase family B protein 0.0018 0.0297 0.0449
Loa Loa (eye worm) hypothetical protein 0.001 0.0105 0.043
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0606 0.8572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.009 0.037
Onchocerca volvulus Putative transporter 0.0014 0.0201 0.068
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0606 0.8572
Onchocerca volvulus 0.0014 0.0201 0.068
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0399 0.6849
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0701 0.5708
Schistosoma mansoni hypothetical protein 0.0019 0.0304 0.0339
Echinococcus multilocularis caspase 0.0032 0.062 0.0691
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0399 0.0399
Onchocerca volvulus 0.0079 0.1715 0.6961
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8572
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0399 0.0603
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.1216 0.9908
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Schistosoma mansoni lipoxygenase 0.0112 0.2489 0.2777
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0012 0.0157 0.3945
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0007 0.0037 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0046
Leishmania major metacaspase, putative 0.0032 0.062 0.5047
Onchocerca volvulus 0.0019 0.0304 0.1107
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0024 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0218 0.3084
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus multilocularis oxidoreductase 0.0007 0.0037 0.0042
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0201 0.2848
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0606 0.8572
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.031 0.4377
Schistosoma mansoni carbonyl reductase 0.0007 0.0037 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.001 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0007 0.0037 0.0644
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0157 0.2224
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0007 0.0037 0.0166
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.009 0.0101
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.062 0.275
Echinococcus granulosus carbonyl reductase 1 0.0007 0.0037 0.0042
Brugia malayi steroid hormone receptor 0.001 0.009 0.037
Loa Loa (eye worm) hypothetical protein 0.0008 0.0058 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.009 0.037
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0007 0.0037 0.0188
Plasmodium falciparum thioredoxin reductase 0.0036 0.0707 0.0707
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0201 0.0823
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0079 0.1715 0.1913
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.0666
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.031 0.2521
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0007 0.0037 0.0042
Brugia malayi hypothetical protein 0.0007 0.0037 0.0153
Mycobacterium tuberculosis Probable dehydrogenase 0.0007 0.0037 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0037 0.053
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0007 0.0037 0.0628
Echinococcus multilocularis General substrate transporter 0.0087 0.1918 0.2139
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2253 0.2514
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Echinococcus multilocularis dnaJ subfamily B 0.0387 0.8965 1
Plasmodium falciparum protein kinase 7 0.0287 0.6612 0.6612
Trypanosoma brucei oxidoreductase-like protein 0.0007 0.0037 0.053
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2253 0.2514
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0007 0.0037 0.0305
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0399 0.3247
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0018 0.0297 0.1318
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0007 0.0037 0.0042
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0399 0.3247
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8572
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0007 0.0037 0.0042
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0188
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2253 0.2514
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Leishmania major protein kinase, putative 0.0031 0.0597 0.4861
Onchocerca volvulus 0.0014 0.0201 0.068
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.1228 0.137
Onchocerca volvulus 0.0014 0.0201 0.068
Mycobacterium ulcerans ketoacyl reductase 0.0007 0.0037 0.0305
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.062 0.0937
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Entamoeba histolytica short chain dehydrogenase family protein 0.0007 0.0037 0.0628
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0582 0.2378
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1228 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0201 0.0225
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0157 0.1281
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0823
Giardia lamblia Hexose transporter 0.0014 0.0201 0.346
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.062 0.2415
Leishmania major quinonoid dihydropteridine reductase 0.0007 0.0037 0.0305
Onchocerca volvulus 0.0014 0.0201 0.068
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0157 0.2224
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.062 0.275
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Loa Loa (eye worm) hypothetical protein 0.003 0.0582 0.2378
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0597 0.0903
Schistosoma mansoni lipoxygenase 0.0078 0.17 0.1896
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0305
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Schistosoma mansoni cpg binding protein 0.0029 0.0541 0.0603
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0201 0.0823
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0399 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0058 0.0256
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0318 0.1592
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0157 0.2224
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.009 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0304 0.1243
Schistosoma mansoni rab6-interacting 0.0019 0.0304 0.0339
Mycobacterium tuberculosis Probable oxidoreductase 0.0007 0.0037 0.0188
Schistosoma mansoni hypothetical protein 0.0102 0.2253 0.2514
Plasmodium falciparum metacaspase-like protein 0.0032 0.062 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.062 0.275
Schistosoma mansoni steroid dehydrogenase 0.0007 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0304 0.1243
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0018 0.0297 0.0331
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.009 0.037
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0018 0.0297 0.1214
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0037 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.009 0.037
Toxoplasma gondii protein kinase, putative 0.0287 0.6612 1
Plasmodium vivax hexose transporter 0.0102 0.2253 0.2253
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Onchocerca volvulus 0.0014 0.0201 0.068
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0153
Echinococcus multilocularis cpg binding protein 0.0029 0.0541 0.0603
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.001 0.0105 0.043
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0061 0.0248
Echinococcus granulosus FTZ F1 alpha 0.001 0.009 0.0101
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Schistosoma mansoni short chain dehydrogenase 0.0007 0.0037 0.0042
Echinococcus granulosus L aminoadipate semialdehyde 0.0079 0.1715 0.1913
Entamoeba histolytica short chain dehydrogenase family protein 0.0007 0.0037 0.0628
Onchocerca volvulus Deterin homolog 0.011 0.2448 1
Trypanosoma brucei sugar transporter, putative 0.0014 0.0201 0.2848
Toxoplasma gondii thioredoxin reductase 0.0036 0.0707 0.107
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.037
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0201 0.0225
Echinococcus granulosus RUN 0.0019 0.0304 0.0339
Mycobacterium ulcerans short chain dehydrogenase 0.0007 0.0037 0.0305
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0018 0.0297 0.4201
Loa Loa (eye worm) thioredoxin reductase 0.0036 0.0707 0.2889
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.037
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0008 0.0058 0.0814
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0012 0.0157 0.0157
Plasmodium falciparum glutathione reductase 0.0036 0.0707 0.0707
Mycobacterium tuberculosis Possible oxidoreductase 0.0007 0.0037 0.0188
Leishmania major short chain dehydrogenase/reductase, putative 0.0007 0.0037 0.0305
Brugia malayi ecdysteroid receptor 0.001 0.009 0.037
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1228 0.137
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0304 0.0339
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.011 0.2448 1
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0018 0.0297 0.5104
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0007 0.0037 0.0628
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0012 0.0157 0.1281
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.1216 0.184
Leishmania major dehydrogenase-like protein 0.0007 0.0037 0.0305
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0007 0.0037 0.0188
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2253 0.2514
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0007 0.0037 0.0628
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0582 0.9752
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0018 0.0297 0.0331
Echinococcus multilocularis caspase 2 0.0032 0.062 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 8.98 uM PubChem BioAssay. VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 16.293 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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