Detailed information for compound 1439424

Basic information

Technical information
  • TDR Targets ID: 1439424
  • Name: 2-[3-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amin o]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]ace tic acid
  • MW: 424.49 | Formula: C24H28N2O5
  • H donors: 2 H acceptors: 4 LogP: 1.26 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(NC1CCc2c(N(C1=O)CC(=O)O)cccc2)CCc1ccccc1
  • InChi: 1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)
  • InChiKey: XPCFTKFZXHTYIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
  • 2-[3-[(1-ethoxycarbonyl-3-phenylpropyl)amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
  • 2-[3-[(1-carbethoxy-3-phenyl-propyl)amino]-2-keto-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
  • 2-[3-[(1-ethoxy-1-oxo-4-phenyl-butan-2-yl)amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]ethanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0125 0.0423
Entamoeba histolytica hypothetical protein 0.004 0.0054 0.1034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0047 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0047 0.0045
Schistosoma mansoni titin 0.0062 0.011 0.0371
Echinococcus multilocularis aminopeptidase N 0.0025 0.0017 0.0021
Schistosoma mansoni slit 0.0062 0.011 0.0371
Trichomonas vaginalis rotamase, putative 0.0035 0.0041 0.0141
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Brugia malayi hypothetical protein 0.004 0.0054 0.0052
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0051 0.0169
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.011 0.0108
Schistosoma mansoni hypothetical protein 0.0622 0.155 0.5305
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.014 0.0312 0.0311
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0117 0.19
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Echinococcus multilocularis Protein lozenge 0.0056 0.0095 0.0138
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0023 0.0012 0.0177
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0012 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0271 0.4356
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0078 0.1289
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0151 0.2822
Onchocerca volvulus 0.0049 0.0078 0.0079
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0049 0.0078 0.1289
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0054 0.0052
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0017 0.0254
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0123 0.1961
Schistosoma mansoni serine-rich repeat protein 0.0622 0.155 0.5305
Loa Loa (eye worm) hypothetical protein 0.0079 0.0154 0.0152
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0107 0.0408
Onchocerca volvulus 0.0031 0.0033 0.003
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0038 0.005 0.0071
Echinococcus granulosus peroxidasin 0.014 0.0312 0.0459
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0006 0.0111
Loa Loa (eye worm) hypothetical protein 0.014 0.0312 0.0311
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0128 0.0279 0.5287
Echinococcus multilocularis titin 0.0062 0.011 0.016
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0107 0.3873
Loa Loa (eye worm) hypothetical protein 0.0053 0.0088 0.0086
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0047 0.0155
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Loa Loa (eye worm) 6-phosphofructokinase 0.0223 0.0525 0.0523
Brugia malayi Ets-domain containing protein 0.0074 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.014 0.0312 0.0311
Leishmania major hypothetical protein, conserved 0.0023 0.0012 0.0099
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0045
Schistosoma mansoni DNA polymerase eta 0.0021 0.0006 0.0013
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0056 0.0094 0.0317
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.014 0.0312 0.0459
Toxoplasma gondii microneme protein MIC2 0.0049 0.0078 0.1234
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0064 0.0941
Echinococcus granulosus metabotropic glutamate receptor 5 0.0238 0.0562 0.083
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0062 0.011 0.016
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0017 0.0051
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0054 0.0077
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0051 0.0073
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0047 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0088 0.0178 0.2923
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0047 0.0045
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0078 0.0076
Echinococcus multilocularis roundabout 2 0.014 0.0312 0.0459
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0079 0.0154 0.0521
Echinococcus granulosus tissue type plasminogen activator 0.0025 0.0015 0.0019
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0012 0.0025
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0056 0.0094 0.0317
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0023 0.0012 0.0014
Echinococcus granulosus nephrin 0.0062 0.011 0.016
Brugia malayi Receptor family ligand binding region containing protein 0.0031 0.0033 0.003
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0017 0.0239
Plasmodium falciparum thioredoxin reductase 0.0088 0.0178 0.2896
Mycobacterium ulcerans hypothetical protein 0.0024 0.0012 0.0182
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0088 0.0178 0.287
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0051 0.0073
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0049 0.0078 0.1234
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.011 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0047 0.0045
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0242 0.0572 0.1954
Loa Loa (eye worm) hypothetical protein 0.0242 0.0572 0.057
Schistosoma mansoni hemicentin 0.0062 0.011 0.0371
Echinococcus multilocularis transfer RNA-Phe 0.0062 0.011 0.016
Echinococcus granulosus titin 0.0062 0.011 0.016
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0017 0.0181
Onchocerca volvulus 0.0062 0.011 0.0114
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0089 0.0298
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0088 0.0178 0.2923
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0054 0.0179
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0088 0.0178 0.2877
Loa Loa (eye worm) hypothetical protein 0.0382 0.0933 0.0931
Schistosoma mansoni cpg binding protein 0.0031 0.0032 0.0105
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0006 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0012 0.0233
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0023 0.0012 0.0014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0052 0.0835
Brugia malayi Immunoglobulin domain containing protein 0.0079 0.0154 0.0152
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0163 0.037 0.0545
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0371
Echinococcus granulosus titin 0.0062 0.011 0.016
Schistosoma mansoni hypothetical protein 0.002 0.0004 0.0008
Schistosoma mansoni regulator of G protein signaling 0.004 0.0054 0.0179
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.001
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0004 0.0069
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0023 0.0012 0.0227
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Onchocerca volvulus 0.0023 0.0012 0.0008
Brugia malayi basement membrane proteoglycan precursor 0.0079 0.0154 0.0152
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0047 0.0155
Loa Loa (eye worm) hypothetical protein 0.0242 0.0572 0.057
Echinococcus multilocularis peroxidasin 0.014 0.0312 0.0459
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0023 0.0012 0.0014
Schistosoma mansoni laminin gamma-3 chain 0.0048 0.0076 0.0255
Loa Loa (eye worm) hypothetical protein 0.014 0.0312 0.0311
Echinococcus multilocularis tyrosine protein kinase otk 0.014 0.0312 0.0459
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0022 0.0008 0.0006
Leishmania major extracellular receptor, putative 0.0022 0.0008 0.0027
Brugia malayi Receptor family ligand binding region containing protein 0.0053 0.0087 0.0085
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0049 0.0078 0.0076
Toxoplasma gondii kringle domain-containing protein 0.0025 0.0015 0.0215
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0047 0.0045
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0255 0.0606 0.9781
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0088 0.0178 0.6361
Schistosoma mansoni neuroglian 0.014 0.0312 0.1064
Leishmania major hypothetical protein, conserved 0.0053 0.0088 0.1332
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Schistosoma mansoni septate junction protein 0.0079 0.0154 0.0521
Echinococcus multilocularis cpg binding protein 0.0031 0.0032 0.0045
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0242 0.0572 0.1954
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0123 0.0121
Entamoeba histolytica hypothetical protein 0.0022 0.0008 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0047 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0192 0.0446 0.7195
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0053 0.0087 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0002
Brugia malayi hypothetical protein 0.0025 0.0017 0.0014
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0064 0.1021
Schistosoma mansoni rab6-interacting 0.002 0.0004 0.0008
Brugia malayi 6-phosphofructokinase 0.0223 0.0525 0.0523
Schistosoma mansoni hypothetical protein 0.0024 0.0013 0.0037
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.0635 0.0937
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0027 0.0036
Echinococcus multilocularis 6 phosphofructokinase 0.0223 0.0525 0.0774
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0048 0.0076 0.0074
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0006 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Loa Loa (eye worm) disorganized muscle protein 1 0.0062 0.011 0.0108
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0017 0.0051
Echinococcus granulosus thioredoxin glutathione reductase 0.0255 0.0606 0.0894
Schistosoma mansoni DNA helicase recq5 0.0038 0.005 0.0165
Brugia malayi von Willebrand Factor 0.0049 0.0078 0.0076
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0023 0.0012 0.0148
Brugia malayi TATA binding protein associated factor 0.0025 0.0017 0.0014
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0038 0.005 0.0048
Loa Loa (eye worm) RGC/RGC protein kinase 0.0031 0.0033 0.0031
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0054 0.0077
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0088 0.0178 0.2877
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0004 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0047 0.0045
Brugia malayi Guanylyl cyclase protein 23 0.0031 0.0033 0.003
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Schistosoma mansoni protein kinase 0.0031 0.0033 0.0105
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.032 0.0774 0.1144
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0102 0.1663
Schistosoma mansoni hypothetical protein 0.0039 0.0051 0.017
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0023 0.0012 0.0162
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0111 0.0236 0.0347
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0038 0.0592
Loa Loa (eye worm) hypothetical protein 0.0048 0.0076 0.0074
Plasmodium vivax thrombospondin-related anonymous protein 0.0049 0.0078 0.1289
Mycobacterium tuberculosis Probable dehydrogenase 0.0128 0.0279 0.4503
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0088 0.0178 0.2877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Chlamydia trachomatis thioredoxin reductase 0.0023 0.0012 0.0402
Echinococcus granulosus leucine rich repeat containing protein 4 0.0062 0.011 0.016
Echinococcus multilocularis tissue type plasminogen activator 0.0025 0.0015 0.0019
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0054 0.0077
Brugia malayi EGF-like domain containing protein 0.0048 0.0076 0.0074
Trichomonas vaginalis mercuric reductase, putative 0.0088 0.0178 0.07
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0117 0.19
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0079 0.0154 0.0521
Brugia malayi hypothetical protein 0.0219 0.0513 0.0511
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0017 0.0275
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0071 0.0069
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0071 0.0135 0.0197
Onchocerca volvulus 0.0037 0.0047 0.0046
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0054 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0088 0.0178 0.2923
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0023 0.0012 0.0014
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0054 0.0052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Brugia malayi steroid hormone receptor 0.0037 0.0047 0.0045
Mycobacterium ulcerans NADH dehydrogenase 0.0023 0.0012 0.0177
Loa Loa (eye worm) programmed cell death 8 0.0023 0.0012 0.001
Schistosoma mansoni loxhd1 0.002 0.0004 0.0008
Echinococcus multilocularis hemicentin 1 0.014 0.0312 0.0459
Treponema pallidum glutamate transporter 0.0056 0.0094 0.0266
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0052 0.0074
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0023 0.0012 0.0227
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.005 0.0781
Echinococcus multilocularis hemicentin 1 0.014 0.0312 0.0459
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0088 0.1362
Schistosoma mansoni ets-related 0.0224 0.0527 0.18
Schistosoma mansoni tyrosine kinase 0.0031 0.0033 0.0105
Loa Loa (eye worm) hypothetical protein 0.066 0.1647 0.1646
Onchocerca volvulus Poor gastrulation protein homolog 0.0031 0.0031 0.0029
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0107 0.0408
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0012 0.0166
Echinococcus granulosus histone lysine methyltransferase setb 0.0124 0.0271 0.0398
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0047 0.0067
Brugia malayi glutamate synthase 0.0023 0.0012 0.001
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0017 0.0014
Echinococcus multilocularis titin 0.0062 0.011 0.016
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0174 0.0171
Echinococcus granulosus neurogenic locus notch protein 0.0048 0.0076 0.011
Loa Loa (eye worm) runx1 0.0056 0.0095 0.0093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0052 0.0835
Echinococcus multilocularis tumor protein p63 0.0364 0.0887 0.1311
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0051 0.0816
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0017 0.0177
Onchocerca volvulus 0.0025 0.0017 0.0013
Schistosoma mansoni lamin 0.0086 0.0174 0.0588
Schistosoma mansoni hypothetical protein 0.0079 0.0154 0.0521
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0111 0.0236 0.0804
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0107 0.1695
Schistosoma mansoni cell adhesion molecule 0.0079 0.0154 0.0521
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0107 0.0301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0071 0.0135 0.0133
Schistosoma mansoni 6-phosphofructokinase 0.0223 0.0525 0.1792
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.014 0.0312 0.0311
Entamoeba histolytica thioredoxin reductase, putative 0.0023 0.0012 0.0227
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0002 0.0003
Schistosoma mansoni cell adhesion molecule 0.014 0.0312 0.1064
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0054 0.0179
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.014 0.0312 0.1064
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0064 0.1211
Schistosoma mansoni hypothetical protein 0.0423 0.1039 0.3555
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0045
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0038 0.0605
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0125 0.0274 0.0289
Echinococcus multilocularis expressed protein 0.0035 0.0041 0.0057
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0038 0.0532
Onchocerca volvulus Basement membrane proteoglycan homolog 0.014 0.0312 0.033
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0012 0.0182
Loa Loa (eye worm) hypothetical protein 0.0242 0.0572 0.057
Echinococcus multilocularis neurogenic locus notch protein 0.0048 0.0076 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0047 0.0067
Chlamydia trachomatis endonuclease IV 0.0078 0.0151 0.5506
Toxoplasma gondii endonuclease IV APN 0.0078 0.0151 0.2417
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0012 0.0025
Schistosoma mansoni peroxidasin 0.0079 0.0154 0.0521
Loa Loa (eye worm) hypothetical protein 0.0078 0.0151 0.0149
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0049 0.0078 0.1229
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0051 0.0739
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0047 0.0067
Onchocerca volvulus 0.0049 0.0078 0.0079
Brugia malayi hypothetical protein 0.0053 0.0088 0.0085
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0023 0.0012 0.0025
Echinococcus granulosus bloom syndrome protein 0.0064 0.0115 0.0167
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Trichomonas vaginalis phosphofructokinase, putative 0.0223 0.0525 0.2104
Schistosoma mansoni regulator of G protein signaling 0.004 0.0054 0.0179
Brugia malayi Heparan sulfate 0.0079 0.0154 0.0152
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0047 0.0067
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0038 0.005 0.0764
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0012 0.0182
Echinococcus multilocularis roundabout 2 0.0382 0.0933 0.1378
Trichomonas vaginalis phosphofructokinase, putative 0.0223 0.0525 0.2104
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0088 0.0178 0.2813
Brugia malayi hypothetical protein 0.0049 0.0078 0.0076
Brugia malayi Ets-domain containing protein 0.0074 0.0141 0.0139
Echinococcus multilocularis thyroid hormone receptor alpha 0.0303 0.073 0.1078
Loa Loa (eye worm) CUTiclin-Like family member 0.0049 0.0078 0.0076
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0023 0.0012 0.0148
Onchocerca volvulus 0.0049 0.0078 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0012 0.0154
Echinococcus multilocularis neuroglian 0.0303 0.073 0.1079
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0012 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0047 0.0045
Echinococcus granulosus dna polymerase eta 0.0021 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0013
Onchocerca volvulus 0.0062 0.011 0.0114
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0004 0.0003
Schistosoma mansoni cell adhesion molecule 0.0062 0.011 0.0371
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0088 0.0178 0.6507
Echinococcus multilocularis neutral amino acid transporter A 0.0125 0.0274 0.0402
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0088 0.0178 0.2945
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0051 0.2627
Echinococcus multilocularis slit 2 protein 0.0048 0.0076 0.011
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0141 0.0206
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0013 0.0016
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0023 0.0012 0.0177
Plasmodium falciparum glutathione reductase 0.0088 0.0178 0.2896
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0012 0.0182
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0107 0.1702
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0054 0.0077
Echinococcus granulosus titin 0.0062 0.011 0.016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0271 0.0922
Trichomonas vaginalis DNA helicase recq1, putative 0.0064 0.0115 0.0443
Schistosoma mansoni basigin related 0.0079 0.0154 0.0521
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0141 0.0139
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0047 0.0067
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.014 0.0312 0.0311
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0123 0.0122
Schistosoma mansoni hypothetical protein 0.0031 0.0031 0.01
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0012 0.0162
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0006 0.0079
Echinococcus granulosus roundabout 2 0.014 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Echinococcus granulosus nmda type glutamate receptor 0.0022 0.0008 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.014 0.0312 0.1064
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0029 0.0027 0.0036
Onchocerca volvulus 0.0049 0.0078 0.0079
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Brugia malayi intermediate filament protein 0.0086 0.0174 0.0171
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0052 0.0758
Treponema pallidum thioredoxin reductase (trxB) 0.0023 0.0012 0.0031
Echinococcus multilocularis nmda type glutamate receptor 0.0022 0.0008 0.0008
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0107 0.1759
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0047 0.0045
Echinococcus granulosus defective proboscis extension response 0.0242 0.0572 0.0844
Loa Loa (eye worm) hypothetical protein 0.0247 0.0587 0.0585
Giardia lamblia Sgs1 DNA helicase, putative 0.0038 0.005 0.2567
Echinococcus granulosus voltage dependent calcium channel subunit 0.1205 0.3045 0.4507
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0025 0.0017 0.0021
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0023 0.0012 0.0129
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0012 0.0154
Echinococcus granulosus tumor protein p63 0.0364 0.0887 0.1311
Brugia malayi Fli-1 protein 0.0224 0.0527 0.0525
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0079 0.0154 0.0225
Echinococcus multilocularis glutamate synthase 0.0023 0.0012 0.0014
Echinococcus multilocularis neutral amino acid transporter A 0.0125 0.0274 0.0402
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0088 0.0178 0.0605
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0054 0.0077
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.0104
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0088 0.0178 0.0176
Entamoeba histolytica phosphofructokinase, putative 0.0223 0.0525 1
Loa Loa (eye worm) CUTiclin family member 0.0049 0.0078 0.0076
Onchocerca volvulus 0.0062 0.011 0.0114
Echinococcus multilocularis insulin growth factor binding 0.0062 0.011 0.016
Schistosoma mansoni polycystin 1-related 0.002 0.0004 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0047 0.0045
Schistosoma mansoni nephrin 0.0303 0.073 0.2497
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.005 0.0048
Toxoplasma gondii thioredoxin reductase 0.0255 0.0606 0.9781
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0006 0.0079
Loa Loa (eye worm) hypothetical protein 0.014 0.0312 0.0311
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0017 0.0208
Onchocerca volvulus 0.0062 0.011 0.0114
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0054 0.0077
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0017 0.0177
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0172 0.0394 0.0392
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0079 0.0154 0.0225
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0054 0.0052
Echinococcus multilocularis Immunoglobulin 0.0079 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0533 0.1321 0.132
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0006 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0124 0.0271 0.0398
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0047 0.0155
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0052 0.0775
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0088 0.0178 0.2923
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0031 0.0031 0.0029
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0023 0.0012 0.0014
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0047 0.0046
Brugia malayi PXA domain containing protein 0.004 0.0054 0.0052
Entamoeba histolytica aminopeptidase, putative 0.0025 0.0017 0.0318
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0006 0.0005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0038 0.0605
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0125 0.0274 0.441
Schistosoma mansoni lipoxygenase 0.002 0.0004 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0047 0.0045
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0052 0.0146
Mycobacterium ulcerans hypothetical protein 0.002 0.0004 0.0052
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0078 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0174 0.0172
Schistosoma mansoni blooms syndrome DNA helicase 0.0044 0.0065 0.0216
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1386 0.3509 1
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0125 0.0274 0.0931
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0052 0.1543
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0017 0.0245
Brugia malayi hypothetical protein 0.0034 0.0039 0.0037
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0107 0.2031
Echinococcus multilocularis roundabout 2 0.014 0.0312 0.0459
Echinococcus granulosus neutral amino acid transporter A 0.0125 0.0274 0.0402
Schistosoma mansoni ap endonuclease 0.0039 0.0052 0.0173
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0078 0.1488
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0047 0.0045
Echinococcus multilocularis titin 0.0062 0.011 0.016
Schistosoma mansoni hypothetical protein 0.0079 0.0154 0.0521
Schistosoma mansoni hypothetical protein 0.0079 0.0154 0.0521
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0088 0.0178 0.2923
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0064 0.0962
Schistosoma mansoni sulfide quinone reductase 0.0023 0.0012 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0047 0.0067
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0079 0.0154 0.0225
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0107 0.1695
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0047 0.0155
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0051 0.0073
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0012 0.0233
Schistosoma mansoni titin 0.0062 0.011 0.0371
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0125 0.0274 1
Schistosoma mansoni titin 0.0062 0.011 0.0371
Echinococcus granulosus dnaJ subfamily B 0.0423 0.1039 0.1535
Schistosoma mansoni cell adhesion molecule 0.032 0.0774 0.2648
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0154 0.0152
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0054 0.0052
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0223 0.0525 0.865
Trichomonas vaginalis phosphofructokinase, putative 0.0223 0.0525 0.2104
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0017 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0006
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0051 0.0756
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0052 0.0864
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.011 0.0108
Echinococcus multilocularis Immunoglobulin 0.0079 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.001
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0079 0.0154 0.0152
Brugia malayi laminin-like protein K08C7.3 precursor 0.0048 0.0076 0.0074
Trypanosoma cruzi trypanothione reductase, putative 0.0255 0.0606 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Echinococcus granulosus neuroglian 0.0303 0.073 0.1079
Echinococcus granulosus low density lipoprotein receptor ldl 0.0079 0.0154 0.0225
Echinococcus granulosus glutamate receptor 2 0.0022 0.0008 0.0008
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0088 0.0178 0.2813
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0123 0.018
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Giardia lamblia NADH oxidase lateral transfer candidate 0.0088 0.0178 1
Echinococcus granulosus roundabout 2 0.014 0.0312 0.0459
Schistosoma mansoni hypothetical protein 0.0079 0.0154 0.0521
Echinococcus granulosus neutral amino acid transporter A 0.0125 0.0274 0.0402
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0051 0.0169
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0078 0.1488
Schistosoma mansoni hypothetical protein 0.0049 0.0078 0.0261
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0862 0.2166 0.2165
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0064 0.0234
Loa Loa (eye worm) hypothetical protein 0.032 0.0774 0.0773
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0023 0.0012 0.0162
Echinococcus multilocularis expressed protein 0.0777 0.1947 0.288
Loa Loa (eye worm) fli-1 protein 0.0224 0.0527 0.0525
Schistosoma mansoni metabotropic glutamate receptor 0.0096 0.02 0.0677
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0088 0.0178 0.2945
Plasmodium falciparum ferrodoxin reductase-like protein 0.0023 0.0012 0.0129
Schistosoma mansoni basigin related 0.0079 0.0154 0.0521
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0079 0.0154 0.0225
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0062 0.011 0.016
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0023 0.0012 0.0102
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0242 0.0572 0.0844
Onchocerca volvulus 0.0049 0.0078 0.0079
Echinococcus granulosus titin 0.0062 0.011 0.016
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0062 0.011 0.0371
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0054 0.0077
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0054 0.0052
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0023 0.0012 0.0227
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Schistosoma mansoni tyrosine kinase 0.015 0.0337 0.115
Schistosoma mansoni survival motor neuron protein 0.005 0.0081 0.0272
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0088 0.1387
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0062 0.011 0.016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0088 0.0178 0.2923
Loa Loa (eye worm) hypothetical protein 0.0053 0.0087 0.0085
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0178 0.2923
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0006 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0047 0.0045
Schistosoma mansoni slit 0.0048 0.0076 0.0255
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0012 0.0182
Leishmania major cathepsin L-like protease 0.0064 0.0117 0.1806
Echinococcus multilocularis dna polymerase eta 0.0021 0.0006 0.0005
Echinococcus granulosus axis inhibition protein axin 0.004 0.0054 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0054 0.0179
Loa Loa (eye worm) hypothetical protein 0.0079 0.0154 0.0152
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0017 0.0015
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0111 0.0236 0.0347
Onchocerca volvulus 0.0446 0.1096 0.117
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Loa Loa (eye worm) hypothetical protein 0.0079 0.0154 0.0152
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0128 0.0279 0.4503
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0006 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0023 0.0012 0.0354
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0052 0.0188
Echinococcus granulosus sodium:dicarboxylate symporter 0.0125 0.0274 0.0402
Chlamydia trachomatis neutral amino acid transporter 0.0056 0.0094 0.3428
Mycobacterium ulcerans monoxygenase 0.0023 0.0012 0.0177
Echinococcus multilocularis RUN 0.002 0.0004 0.0003
Brugia malayi hypothetical protein 0.0039 0.0051 0.0049
Brugia malayi hypothetical protein 0.0079 0.0154 0.0152
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0023 0.0012 0.0166
Schistosoma mansoni titin 0.0062 0.011 0.0371
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0017 0.0014
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0038 0.005 0.0071
Leishmania major hypothetical protein, conserved 0.0023 0.0012 0.0099
Echinococcus granulosus neutral amino acid transporter 0.0125 0.0274 0.0402
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0371
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0027 0.0036
Loa Loa (eye worm) 6-phosphofructokinase 0.0223 0.0525 0.0523
Giardia lamblia Glutamate synthase 0.0023 0.0012 0.0354
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0023 0.0012 0.0025
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0017 0.0208
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0023 0.0012 0.001
Schistosoma mansoni lozenge 0.0056 0.0095 0.032
Entamoeba histolytica hypothetical protein 0.004 0.0054 0.1034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0154 0.0152
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0047 0.0155
Leishmania major cathepsin L-like protease 0.0064 0.0117 0.1806
Echinococcus granulosus collagen alpha 1VII chain 0.0049 0.0078 0.0112
Brugia malayi follicle stimulating hormone receptor 0.0483 0.1192 0.119
Echinococcus granulosus tyrosine protein kinase otk 0.014 0.0312 0.0459
Brugia malayi Prion-like- 0.0062 0.011 0.0108
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0223 0.0525 0.8471
Treponema pallidum NADH oxidase 0.0088 0.0178 0.0506
Onchocerca volvulus 0.0025 0.0017 0.0013
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0079 0.0154 0.0225
Schistosoma mansoni hypothetical protein 0.0079 0.0154 0.0521
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.011 0.0371
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0107 0.1695
Brugia malayi nuclear receptor NHR-88 0.0037 0.0047 0.0045
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0023 0.0012 0.0025
Loa Loa (eye worm) RGS-3 protein 0.004 0.0054 0.0052
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0023 0.0012 0.0177
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0012 0.0104
Schistosoma mansoni intermediate filament proteins 0.0086 0.0174 0.0588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0047 0.0045
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0017 0.0254
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0056 0.0094 0.0137
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2649 0.6754 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0023 0.0012 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0047 0.0045
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0111 0.0236 0.0804
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.011 0.0108
Brugia malayi Disorganized muscle protein 1 0.0062 0.011 0.0108
Loa Loa (eye worm) hypothetical protein 0.0079 0.0154 0.0152
Brugia malayi Bloom's syndrome protein homolog 0.0064 0.0115 0.0113
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0062 0.011 0.016
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0192 0.0446 0.7195
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0049 0.0078 0.0112
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0054 0.0077
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0023 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Toxoplasma gondii exonuclease III APE 0.0039 0.0052 0.0816
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0038 0.005 0.0071
Brugia malayi hypothetical protein 0.004 0.0054 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0047 0.0045
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0017 0.0044
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0017 0.0044
Brugia malayi Prion-like- 0.0062 0.011 0.0108
Onchocerca volvulus 0.0062 0.011 0.0114
Echinococcus granulosus Immunoglobulin 0.0079 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Schistosoma mansoni roundabout 0.014 0.0312 0.1064
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0027 0.0036
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.011 0.0108
Brugia malayi glutathione reductase 0.0255 0.0606 0.0604
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0047 0.0155
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0022 0.0008 0.0008
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0052 0.2693
Brugia malayi Cache domain containing protein 0.0533 0.1321 0.1319
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0088 0.0178 0.2877
Schistosoma mansoni septate junction protein 0.0079 0.0154 0.0521
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0079 0.0154 0.0521
Brugia malayi Thioredoxin reductase 0.0255 0.0606 0.0604
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0271 0.0398
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0045
Schistosoma mansoni 6-phosphofructokinase 0.0223 0.0525 0.1792
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0088 0.0178 0.287
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0006
Leishmania major cathepsin L-like protease 0.0064 0.0117 0.1806
Entamoeba histolytica disulphide oxidoreductase, putative 0.0023 0.0012 0.0227
Schistosoma mansoni regulator of G protein signaling 0.004 0.0054 0.0179
Onchocerca volvulus 0.0025 0.0017 0.0013
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0079 0.0154 0.0225
Echinococcus granulosus glutamate synthase 0.0023 0.0012 0.0014
Echinococcus multilocularis neuroglian 0.014 0.0312 0.0459
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0017 0.0245
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0006 0.0013
Echinococcus multilocularis excitatory amino acid transporter 2 0.0125 0.0274 0.0402
Brugia malayi hypothetical protein 0.0025 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.014 0.0312 0.0311
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.004 0.0053 0.0882
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0017 0.0177
Loa Loa (eye worm) thioredoxin reductase 0.0255 0.0606 0.0604
Schistosoma mansoni septate junction protein 0.014 0.0312 0.1064
Loa Loa (eye worm) aminopeptidase N 0.0025 0.0017 0.0015
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0059 0.0084
Loa Loa (eye worm) hypothetical protein 0.0053 0.0089 0.0087
Brugia malayi metabotropic glutamate receptor type 2 0.0096 0.02 0.0197
Loa Loa (eye worm) hypothetical protein 0.0238 0.0562 0.0561
Echinococcus granulosus aminopeptidase N 0.0025 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Onchocerca volvulus 0.0049 0.0078 0.0079
Leishmania major hypothetical protein, conserved 0.0025 0.0015 0.0153
Schistosoma mansoni hypothetical protein 0.005 0.0081 0.0272
Echinococcus granulosus lamin 0.0086 0.0174 0.0254
Trichomonas vaginalis phosphofructokinase, putative 0.0223 0.0525 0.2104
Echinococcus granulosus glutamate receptor 2 0.0029 0.0027 0.0036
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0058 0.0102 0.162
Echinococcus granulosus axis inhibition protein axin 0.004 0.0054 0.0077
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0047 0.0155
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Leishmania major NADH dehydrogenase, putative 0.0023 0.0012 0.0099
Echinococcus multilocularis excitatory amino acid transporter 2 0.0125 0.0274 0.0402
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.014 0.0312 0.0459
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0047 0.0155
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.011 0.0108
Echinococcus granulosus Immunoglobulin 0.0079 0.0154 0.0225
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0051 0.0073
Schistosoma mansoni nephrin 0.014 0.0312 0.1064
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0025 0.0017 0.0051
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0017 0.0275
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0128 0.0279 0.4503
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0154 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0271 0.0922
Echinococcus multilocularis excitatory amino acid transporter 3 0.0125 0.0274 0.0402
Schistosoma mansoni axis inhibition protein axin 0.004 0.0054 0.0179
Echinococcus granulosus Immunoglobulin 0.0242 0.0572 0.0844
Plasmodium falciparum thioredoxin reductase 0.0255 0.0606 1
Schistosoma mansoni hypothetical protein 0.0175 0.0402 0.1372
Brugia malayi Myb-like DNA-binding domain containing protein 0.0062 0.011 0.0108
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0151 0.2428
Trypanosoma cruzi NADH dehydrogenase, putative 0.0023 0.0012 0.0166
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0029
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0054 0.0077
Echinococcus granulosus contactin 0.014 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0242 0.0572 0.057
Echinococcus multilocularis lachesin 0.014 0.0312 0.0459
Loa Loa (eye worm) RecQ helicase 0.0064 0.0115 0.0113
Schistosoma mansoni myosin-binding protein-related 0.0062 0.011 0.0371
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Brugia malayi Animal haem peroxidase family protein 0.0062 0.011 0.0108
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0051 0.0975
Echinococcus granulosus insulin growth factor binding 0.0062 0.011 0.016
Loa Loa (eye worm) hypothetical protein 0.0079 0.0154 0.0152
Echinococcus multilocularis receptor type guanylyl cyclase 0.0031 0.0033 0.0045
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0023 0.0012 0.0177
Brugia malayi basement membrane proteoglycan 0.0079 0.0154 0.0152
Entamoeba histolytica elongation factor-2 kinase, putative 0.0049 0.0078 0.1488
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0023 0.0012 0.0177
Schistosoma mansoni axis inhibition protein axin 0.004 0.0054 0.0179
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0012 0.0166
Loa Loa (eye worm) cytochrome P450 family protein 0.0073 0.0138 0.0137
Loa Loa (eye worm) doublecortin family protein 0.002 0.0004 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0047 0.0155
Mycobacterium ulcerans hypothetical protein 0.0023 0.0012 0.0177
Entamoeba histolytica phosphofructokinase, putative 0.0223 0.0525 1
Schistosoma mansoni thyroid hormone receptor 0.0303 0.073 0.2497
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0107 0.0408
Brugia malayi Excitatory amino acid transporter 0.0125 0.0274 0.0272
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Echinococcus multilocularis Excitatory amino acid transporter 0.0125 0.0274 0.0402
Onchocerca volvulus 0.0124 0.0271 0.0286
Loa Loa (eye worm) glutamate receptor 0.0194 0.045 0.0448
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.011 0.0371
Loa Loa (eye worm) hypothetical protein 0.0111 0.0236 0.0235
Mycobacterium ulcerans 6-phosphofructokinase 0.0223 0.0525 0.8471
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0054 0.0077
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0238 0.0562 0.083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.0015
Echinococcus multilocularis lamin dm0 0.0086 0.0174 0.0254
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0078 0.0076
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0012 0.0025
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0371
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0062 0.011 0.016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0006
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.002 0.0027
Brugia malayi Metabotropic glutamate receptor precursor. 0.0194 0.045 0.0448
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.0063 0.0114 0.0112
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0023 0.0012 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0051 0.0184
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0049 0.0078 0.0293
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0054 0.0052
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0361 0.0879 0.0877
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.0587 0.0867
Schistosoma mansoni netrin receptor unc5 0.0079 0.0154 0.0521
Echinococcus granulosus excitatory amino acid transporter 2 0.0125 0.0274 0.0402
Schistosoma mansoni netrin receptor unc5 0.0079 0.0154 0.0521
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0054 0.0052
Echinococcus multilocularis lamin 0.0086 0.0174 0.0254
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0056 0.0094 0.0137
Loa Loa (eye worm) TK protein kinase 0.0071 0.0135 0.0133
Schistosoma mansoni tyrosine kinase 0.0031 0.0033 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0052 0.0804
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0006 0.0065
Giardia lamblia Thioredoxin reductase 0.0023 0.0012 0.0354
Onchocerca volvulus 0.3583 0.9152 0.9803
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.014 0.0312 0.0459
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.1039 0.1535
Toxoplasma gondii aldehyde dehydrogenase 0.026 0.0619 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0017 0.0177
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0052 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0088 0.0178 0.2923
Schistosoma mansoni thyroid hormone receptor 0.0303 0.073 0.2497
Echinococcus granulosus Excitatory amino acid transporter 0.0125 0.0274 0.0402
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0023 0.0012 0.0166
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0088 0.0178 0.287
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0025 0.0015 0.0251
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0023 0.0012 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0619 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1156 0.2919 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0023 0.0012 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Schistosoma mansoni regulator of G protein signaling 0.004 0.0054 0.0179
Treponema pallidum glutamate/aspartate transporter 0.0056 0.0094 0.0266
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0017 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0012 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0012 0.0166
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0054 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0071 0.0135 0.0197
Brugia malayi Prion-like- 0.0062 0.011 0.0108
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0079 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni cpg binding protein 0.003 0.0028 0.009
Echinococcus granulosus tyrosine kinase 0.0031 0.0033 0.0045
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0006 0.0079
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0023 0.0012 0.0102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0052 0.0074
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0023 0.0012 0.0025
Echinococcus granulosus titin 0.0062 0.011 0.016
Toxoplasma gondii NADPH-glutathione reductase 0.0088 0.0178 0.2859
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0017 0.0245
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0088 0.1418
Schistosoma mansoni cell polarity protein 0.0048 0.0076 0.0255
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.2246 0.5719 0.5718
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0027 0.0036
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0023 0.0012 0.0014
Echinococcus multilocularis titin 0.0062 0.011 0.016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0154 0.0152
Echinococcus multilocularis down syndrome cell adhesion 0.0062 0.011 0.016
Chlamydia trachomatis glutamate symporter 0.0125 0.0274 1
Loa Loa (eye worm) one IG domain family member 0.0062 0.011 0.0108
Brugia malayi ecdysteroid receptor 0.0037 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0052
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0051 0.0049
Schistosoma mansoni lamin 0.0086 0.0174 0.0588
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0371
Echinococcus multilocularis Immunoglobulin 0.0242 0.0572 0.0844
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0088 0.1418
Echinococcus granulosus slit 2 protein 0.0048 0.0076 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0047 0.0045
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0079 0.0154 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0196
Brugia malayi Immunoglobulin I-set domain containing protein 0.0291 0.0698 0.0696
Loa Loa (eye worm) hypothetical protein 0.014 0.0312 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.0076 0.0074
Schistosoma mansoni titin 0.014 0.0312 0.1064
Entamoeba histolytica hypothetical protein 0.0039 0.0051 0.0979
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0619 0.2116
Schistosoma mansoni titin 0.0062 0.011 0.0371
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0108 0.172
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0017 0.0181
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0012 0.0182
Brugia malayi Peroxidasin 0.014 0.0312 0.031
Schistosoma mansoni titin 0.0062 0.011 0.0371
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0054 0.0196
Loa Loa (eye worm) hypothetical protein 0.0124 0.0271 0.0269
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Trichomonas vaginalis rotamase, putative 0.0034 0.0038 0.0132
Loa Loa (eye worm) hypothetical protein 0.0048 0.0076 0.0074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0192 0.0446 0.8485
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Onchocerca volvulus 0.0062 0.011 0.0114
Echinococcus multilocularis bloom syndrome protein 0.0064 0.0115 0.0167
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0619 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0047 0.0067
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0483 0.1192 0.119
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0196
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0023 0.0012 0.0177
Loa Loa (eye worm) abnormal epIthelia family member 0.0048 0.0076 0.0074
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0051 0.0184
Plasmodium vivax SET domain protein, putative 0.0124 0.0271 0.4472
Schistosoma mansoni hypothetical protein 0.0049 0.0078 0.0261
Brugia malayi kettin 0.0062 0.011 0.0108
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0004 0.0002
Echinococcus granulosus GPCR family 3 C terminal 0.0031 0.0031 0.0043
Schistosoma mansoni gabp alpha 0.0074 0.0141 0.0478
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0053
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0088 0.0178 0.2896
Schistosoma mansoni hypothetical protein 0.0266 0.0635 0.217
Echinococcus granulosus intermediate filament protein 0.0086 0.0174 0.0254
Schistosoma mansoni hypothetical protein 0.0175 0.0402 0.1372
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0047 0.0067
Entamoeba histolytica hypothetical protein 0.0039 0.0051 0.0979
Trichomonas vaginalis DNA helicase recq, putative 0.0064 0.0115 0.0443
Schistosoma mansoni metabotropic glutamate receptor 0.0163 0.037 0.1263
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0023 0.0012 0.0177
Echinococcus multilocularis GPCR, family 3, C terminal 0.0031 0.0031 0.0043
Echinococcus granulosus Immunoglobulin subtype 0.0079 0.0154 0.0225
Plasmodium falciparum glutathione reductase 0.0255 0.0606 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0045
Plasmodium falciparum thrombospondin-related anonymous protein 0.0049 0.0078 0.1229
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0004 0.0003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0107 0.1702
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0006 0.0065
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0038 0.0733
Echinococcus granulosus excitatory amino acid transporter 3 0.0125 0.0274 0.0402
Schistosoma mansoni cell adhesion molecule 0.0079 0.0154 0.0521
Echinococcus multilocularis netrin receptor unc 5 0.0079 0.0154 0.0225
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0051 0.0073
Schistosoma mansoni hypothetical protein 0.0079 0.0154 0.0521
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0099 0.0143
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1205 0.3045 0.4507
Echinococcus granulosus RUN 0.002 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0078 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Schistosoma mansoni glutamate synthase 0.0023 0.0012 0.0034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Brugia malayi Protein kinase domain containing protein 0.0034 0.004 0.0038
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0023 0.0012 0.0148
Onchocerca volvulus 0.0062 0.011 0.0114
Echinococcus granulosus cpg binding protein 0.0031 0.0032 0.0045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0192 0.0446 0.7195
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0052 0.083
Onchocerca volvulus 0.0062 0.011 0.0114
Loa Loa (eye worm) projectin 0.0062 0.011 0.0108
Mycobacterium ulcerans dehydrogenase 0.0023 0.0012 0.0177
Brugia malayi CXXC zinc finger family protein 0.003 0.0028 0.0026
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0079 0.0154 0.0521
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0023 0.0012 0.0177
Brugia malayi Zona pellucida-like domain containing protein 0.0049 0.0078 0.0076
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0022 0.0008 0.0005
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0151 0.2443
Echinococcus granulosus neuroglian 0.014 0.0312 0.0459
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0054 0.0179
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.0312 0.031
Brugia malayi Kringle domain containing protein 0.0025 0.0015 0.0013
Echinococcus granulosus hemicentin 1 0.014 0.0312 0.0459
Schistosoma mansoni basigin related 0.0079 0.0154 0.0521
Onchocerca volvulus Netrin receptor homolog 0.0062 0.011 0.0114
Loa Loa (eye worm) TK/ROR protein kinase 0.0096 0.0199 0.0197
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0048 0.0076 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0078 0.0076
Onchocerca volvulus 0.0024 0.0012 0.0009
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0004 0.0052
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0088 0.0178 0.0261
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0107 0.5838
Brugia malayi Immunoglobulin domain containing protein 0.0079 0.0154 0.0152
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0065 0.0118 0.0116
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0182
Trichomonas vaginalis apoptosis inducing factor, putative 0.0023 0.0012 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0047 0.0045
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0081 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Loa Loa (eye worm) hypothetical protein 0.0086 0.0174 0.0172
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0054 0.0052
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0049 0.0078 0.0076
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0078 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0051 0.0073
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0054 0.0077
Trypanosoma brucei NADH dehydrogenase 0.0023 0.0012 0.0102
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0051 0.017
Plasmodium vivax ferrodoxin reductase, putative 0.0023 0.0012 0.0197
Treponema pallidum oxidoreductase 0.0023 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0446 0.1096 0.1095
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0006 0.0079
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0017 0.0245
Schistosoma mansoni cell adhesion molecule 0.014 0.0312 0.1064
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0107 0.3873
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0088 0.0178 0.2859
Echinococcus multilocularis 0.0062 0.011 0.016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0027 0.0036
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0123 0.2013
Onchocerca volvulus 0.0049 0.0078 0.0079
Treponema pallidum 76K protein 0.0049 0.0078 0.022
Schistosoma mansoni ap endonuclease 0.0039 0.0052 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Echinococcus multilocularis contactin neuroglian septate junction protein 0.014 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0242 0.0572 0.057
Echinococcus multilocularis Immunoglobulin 0.0242 0.0572 0.0844
Onchocerca volvulus 0.0062 0.011 0.0114
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0223 0.0525 1
Echinococcus granulosus Excitatory amino acid transporter 0.0125 0.0274 0.0402
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0029 0.0027 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0012 0.0102
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0054 0.0077
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0027 0.0036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0196
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0023 0.0012 0.0177
Entamoeba histolytica phosphofructokinase, putative 0.0223 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0382 0.0933 0.0931
Plasmodium vivax glutathione reductase, putative 0.0255 0.0606 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0023 0.0012 0.0014
Onchocerca volvulus 0.0086 0.0174 0.0182
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0271 0.0922
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0023 0.0012 0.0177
Loa Loa (eye worm) RGC/RGC protein kinase 0.0031 0.0033 0.0031
Brugia malayi hypothetical protein 0.0247 0.0587 0.0585
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0088 0.0178 0.0261
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0151 0.2495
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0041 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0041 0.0141
Loa Loa (eye worm) LAD-2 short isoform 0.0079 0.0154 0.0152
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Schistosoma mansoni cpg binding protein 0.0031 0.0032 0.0105
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0051 0.0073
Entamoeba histolytica hypothetical protein 0.0039 0.0051 0.0979
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.005 0.0781
Schistosoma mansoni rab6-interacting 0.002 0.0004 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0107 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0154 0.0152
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.014 0.0312 0.0459
Brugia malayi Pre-SET motif family protein 0.0124 0.0271 0.0269
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0054 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0117 0.1847
Trypanosoma cruzi extracellular receptor, putative 0.0022 0.0008 0.0093
Loa Loa (eye worm) hypothetical protein 0.0111 0.0236 0.0235
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0006
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0023 0.0012 0.0148
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0223 0.0525 0.8659
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0047 0.0067
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0079 0.0154 0.0225
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0047 0.0045
Echinococcus multilocularis Excitatory amino acid transporter 0.0125 0.0274 0.0402
Brugia malayi nuclear hormone receptor 0.0037 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0052
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.026 0.0619 0.0914
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0128 0.0279 0.4503
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0271 0.0922
Leishmania major trypanothione reductase 0.0255 0.0606 0.9779
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0023 0.0012 0.0166
Echinococcus granulosus leukotriene A 4 hydrolase 0.0361 0.0879 0.1299
Schistosoma mansoni septate junction protein 0.014 0.0312 0.1064
Plasmodium vivax thioredoxin reductase, putative 0.0255 0.0606 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0049 0.0078 0.0076
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0031 0.0033 0.003
Echinococcus granulosus expressed protein 0.0777 0.1947 0.288
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0047 0.0045
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0017 0.0245
Brugia malayi Immunoglobulin domain containing protein 0.0079 0.0154 0.0152
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0216 0.0507 0.173
Mycobacterium tuberculosis Probable reductase 0.0128 0.0279 0.4503
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0361 0.0879 0.3006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0006 0.0065
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.014 0.0312 0.0311
Schistosoma mansoni cell adhesion molecule 0.0062 0.011 0.0371
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0017 0.0245
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0088 0.1445
Echinococcus granulosus basement membrane specific heparan sulfate 0.0079 0.0154 0.0225
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0023 0.0012 0.0197
Schistosoma mansoni cell adhesion molecule 0.0062 0.011 0.0371
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0053
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0123 0.2013
Treponema pallidum hypothetical protein 0.0049 0.0078 0.022
Loa Loa (eye worm) glutamate receptor 0.0075 0.0144 0.0142
Schistosoma mansoni regulator of G protein signaling 0.004 0.0054 0.0179
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0006 0.0005
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3913 1 1
Schistosoma mansoni hypothetical protein 0.0025 0.0015 0.0046
Schistosoma mansoni rotamase 0.0035 0.0041 0.0132
Echinococcus granulosus lamin dm0 0.0086 0.0174 0.0254
Echinococcus granulosus excitatory amino acid transporter 2 0.0125 0.0274 0.0402
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0023 0.0012 0.0014
Plasmodium falciparum cysteine repeat modular protein 1 0.0025 0.0015 0.0183
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0027 0.002 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0107 0.0408
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0371
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Leishmania major ATP-dependent phosphofructokinase 0.0223 0.0525 0.8459
Schistosoma mansoni hypothetical protein 0.0023 0.0012 0.0034
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0371
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0012 0.0166
Loa Loa (eye worm) hypothetical protein 0.014 0.0312 0.0311
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0088 0.0178 0.2813
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0125 0.0274 0.0402
Onchocerca volvulus Peroxidasin homolog 0.0062 0.011 0.0114
Trypanosoma cruzi NADH dehydrogenase, putative 0.0023 0.0012 0.0166
Trypanosoma cruzi Aminopeptidase M1, putative 0.0025 0.0017 0.0245
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0062 0.011 0.0108
Loa Loa (eye worm) phosphofructokinase 0.0223 0.0525 0.0523
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Toxoplasma gondii selenide, water dikinase 0.0023 0.0012 0.0162
Onchocerca volvulus 0.0025 0.0015 0.0012
Echinococcus granulosus down syndrome cell adhesion 0.0062 0.011 0.016
Loa Loa (eye worm) hypothetical protein 0.0446 0.1096 0.1095
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0049 0.0078 0.1229
Echinococcus granulosus atrial natriuretic peptide receptor 0.0022 0.0008 0.0008
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0052 0.083
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0088 0.0178 0.2896
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.011 0.0108
Mycobacterium ulcerans ferredoxin reductase 0.0023 0.0012 0.0177
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0052
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0027 0.0036
Mycobacterium ulcerans glutamate synthase subunit beta 0.0023 0.0012 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0088 0.0178 0.6361
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.002 0.0027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0002 0.0001
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0038 0.005 0.0071
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0054 0.0052
Brugia malayi PXA domain containing protein 0.004 0.0054 0.0052
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0017 0.0239
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0062 0.011 0.016
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0047 0.0067
Brugia malayi hypothetical protein 0.002 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0062 0.011 0.016
Entamoeba histolytica hypothetical protein 0.0049 0.0078 0.1488
Entamoeba histolytica hypothetical protein 0.004 0.0054 0.1034
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0012 0.0233
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0088 0.0178 0.2813
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0079 0.0154 0.0225
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0151 0.0149
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0053 0.0087 0.0085
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0065 0.0118 0.0116
Onchocerca volvulus 0.0062 0.011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0045
Brugia malayi Fibronectin type III domain containing protein 0.0242 0.0572 0.057
Schistosoma mansoni vesicular amine transporter 0.0242 0.0572 0.1954
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0023 0.0012 0.0014
Schistosoma mansoni coup transcription factor 0.0037 0.0047 0.0155
Schistosoma mansoni lipoxygenase 0.0057 0.0099 0.0331
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0047 0.0067
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0099 0.0143
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0619 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0012 0.0162
Mycobacterium ulcerans endonuclease IV 0.0078 0.0151 0.2428
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0023 0.0012 0.0177
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0081 0.1316
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0012 0.0025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0047 0.0155
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0088 0.1385
Schistosoma mansoni hypothetical protein 0.0062 0.011 0.0371
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0006 0.0065
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0078 0.0076
Onchocerca volvulus Tyrosine kinase homolog 0.3655 0.9336 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0258 0.0378
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0012 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0047 0.0045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.011 0.0108
Loa Loa (eye worm) excitatory amino acid transporter 0.0125 0.0274 0.0272
Brugia malayi Pre-SET motif family protein 0.0862 0.2166 0.2165
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0054 0.0052
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0017 0.0245
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0027 0.0085
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0123 0.0417
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0029 0.0026 0.0081
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0004 0.0052
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0054 0.0077
Brugia malayi protein unc-22 0.0062 0.011 0.0108
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0062 0.011 0.0108
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0111 0.0236 0.0804
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0052 0.005
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0041 0.0038
Schistosoma mansoni titin 0.0062 0.011 0.0371
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0088 0.1385
Loa Loa (eye worm) hypothetical protein 0.0085 0.017 0.0168
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0059 0.0084
Onchocerca volvulus 0.003 0.0028 0.0026
Loa Loa (eye worm) RGC/RGC protein kinase 0.0031 0.0033 0.0031
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0223 0.0525 0.1493
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0047 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0012 0.0182
Echinococcus granulosus receptor type guanylyl cyclase 0.0031 0.0033 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0052 0.005
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0012 0.0162
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.2107 0.3117
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0128 0.0279 0.4503
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0196
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0047 0.0067
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0049 0.0078 0.1289
Brugia malayi Cytochrome P450 family protein 0.0073 0.0138 0.0136
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.0048
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0006 0.0005
Leishmania major hypothetical protein, conserved 0.0023 0.0012 0.0099
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0023 0.0012 0.0099
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0071 0.0068
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0051 0.0184
Trypanosoma brucei trypanothione reductase 0.0255 0.0606 1
Brugia malayi hypothetical protein 0.0446 0.1096 0.1094
Brugia malayi hypothetical protein 0.002 0.0004 0.0002
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0023 0.0012 0.0227
Brugia malayi Leucine Rich Repeat family protein 0.0062 0.011 0.0108
Echinococcus granulosus dna polymerase kappa 0.0021 0.0006 0.0005
Onchocerca volvulus Putative titin 0.0062 0.011 0.0114
Onchocerca volvulus 0.005 0.0081 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0054 0.0196
Echinococcus granulosus twitchin 0.0303 0.073 0.1079
Onchocerca volvulus 0.0062 0.011 0.0114
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0038 0.0544
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0017 0.0239
Echinococcus multilocularis tyrosine kinase 0.0031 0.0033 0.0045
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0123 0.018
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0023 0.0012 0.0129
Brugia malayi hypothetical protein 0.0242 0.0572 0.057
Brugia malayi hypothetical protein 0.0022 0.0008 0.0005
Echinococcus multilocularis geminin 0.0175 0.0402 0.0592
Loa Loa (eye worm) hypothetical protein 0.0045 0.0067 0.0065
Mycobacterium ulcerans epimerase 0.002 0.0004 0.0052
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.014 0.0312 0.0459
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0023 0.0012 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.011 0.0108
Echinococcus granulosus voltage dependent calcium channel subunit 0.2649 0.6754 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0017 0.0015
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0023 0.0012 0.001
Entamoeba histolytica hypothetical protein 0.0039 0.0051 0.0979
Brugia malayi Angiotensin-converting enzyme family protein 0.2246 0.5719 0.5718
Onchocerca volvulus Peroxidasin homolog 0.0062 0.011 0.0114
Echinococcus multilocularis pikachurin 0.0048 0.0076 0.011
Schistosoma mansoni glutamate synthase 0.0023 0.0012 0.0034
Onchocerca volvulus 0.0053 0.0089 0.0091
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.026 0.0619 1
Echinococcus granulosus netrin receptor unc 5 0.0079 0.0154 0.0225
Brugia malayi 6-phosphofructokinase 0.0223 0.0525 0.0523
Schistosoma mansoni DNA helicase recq1 0.0038 0.005 0.0165
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0123 0.2353
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Echinococcus granulosus roundabout 2 0.0382 0.0933 0.1378
Schistosoma mansoni nephrin related 0.0062 0.011 0.0371
Loa Loa (eye worm) hypothetical protein 0.0042 0.0059 0.0057
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0107 0.1759
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0076
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.026 0.0619 0.0914
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0031 0.0031 0.0029
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0583 0.1448 0.4956
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0088 0.0178 0.2923
Loa Loa (eye worm) hypothetical protein 0.0242 0.0572 0.057
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.026 0.0619 1
Echinococcus granulosus expressed protein 0.0035 0.0041 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0117 0.19
Loa Loa (eye worm) animal heme peroxidase 0.0062 0.011 0.0108
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0002 0.0001
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0079 0.0154 0.0521
Schistosoma mansoni nephrin related 0.0079 0.0154 0.0521
Loa Loa (eye worm) glutathione reductase 0.0255 0.0606 0.0604
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0117 0.19
Brugia malayi laminin alpha chain 0.0048 0.0076 0.0074
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0028 0.0026
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0054 0.0179
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0141 0.0206
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0049 0.0078 0.1289
Echinococcus multilocularis neutral amino acid transporter A 0.0125 0.0274 0.0402
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0051 0.0073
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0023 0.0012 0.0227
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0107 0.0408
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0004 0.0000020175
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0015 0.022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0051 0.0816
Entamoeba histolytica recQ family DNA helicase 0.002 0.0002 0.0036
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.0078 0.0076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0047 0.0067
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0013 0.0016
Onchocerca volvulus 0.0982 0.2472 0.2645
Schistosoma mansoni glutamate synthase 0.0023 0.0012 0.0034
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0017 0.0181
Onchocerca volvulus 0.0022 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0062 0.011 0.0108
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0619 0.2116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0051 0.0073
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0012 0.0182
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.0635 0.0937
Echinococcus granulosus geminin 0.0175 0.0402 0.0592
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0047 0.0067
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0006
Schistosoma mansoni cell adhesion molecule 0.014 0.0312 0.1064
Loa Loa (eye worm) CAMK protein kinase 0.0062 0.011 0.0108
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0052 0.0997
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0123 0.1917
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0047 0.0067
Echinococcus multilocularis Immunoglobulin subtype 0.0079 0.0154 0.0225
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0049
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0174 0.0172
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0088 0.0178 0.287
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0023 0.0012 0.0177
Echinococcus multilocularis thioredoxin glutathione reductase 0.0255 0.0606 0.0894
Schistosoma mansoni disulfide oxidoreductase 0.0023 0.0012 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0982 0.2472 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0051 0.0073
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0054 0.0052
Trichomonas vaginalis glutamate synthase, putative 0.0023 0.0012 0.0025
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.0587 0.0867
Echinococcus granulosus metabotropic glutamate receptor 2 0.0163 0.037 0.0545
Brugia malayi Doublecortin family protein 0.002 0.0004 0.0002
Trichomonas vaginalis glutamate synthase, putative 0.0023 0.0012 0.0025
Echinococcus granulosus lachesin 0.014 0.0312 0.0459
Brugia malayi hypothetical protein 0.0253 0.0602 0.06
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0361 0.0879 0.1299
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0023 0.0012 0.0177
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0054 0.0179
Echinococcus granulosus 6 phosphofructokinase 0.0223 0.0525 0.0774
Onchocerca volvulus 0.0086 0.0174 0.0182
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0017 0.0181
Brugia malayi Zona pellucida-like domain containing protein 0.0049 0.0078 0.0076
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0125 0.0274 0.0402
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0023 0.0012 0.0014
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0047 0.0046
Brugia malayi Prion-like- 0.014 0.0312 0.031
Echinococcus multilocularis twitchin 0.0062 0.011 0.016
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.014 0.0312 0.0311
Trichomonas vaginalis glutathione reductase, putative 0.0088 0.0178 0.07
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0017 0.0021
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0004 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0047 0.0067
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0054 0.0179
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0107 0.0408
Schistosoma mansoni sulfide quinone reductase 0.0023 0.0012 0.0034
Echinococcus multilocularis musashi 0.0086 0.0174 0.0254
Brugia malayi phosphofructokinase 0.0223 0.0525 0.0523
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0054 0.0077
Echinococcus granulosus pikachurin 0.0048 0.0076 0.011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0052 0.08

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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