Detailed information for compound 1548530

Basic information

Technical information
  • TDR Targets ID: 1548530
  • Name: 4-(4-fluorophenyl)sulfonyl-N-(oxolan-2-ylmeth yl)piperazine-1-carbothioamide
  • MW: 387.493 | Formula: C16H22FN3O3S2
  • H donors: 0 H acceptors: 2 LogP: 1.54 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=NCC1CCCO1)S
  • InChi: 1S/C16H22FN3O3S2/c17-13-3-5-15(6-4-13)25(21,22)20-9-7-19(8-10-20)16(24)18-12-14-2-1-11-23-14/h3-6,14H,1-2,7-12H2,(H,18,24)
  • InChiKey: JTNBPEWEDPZTAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-fluorophenyl)sulfonyl-N-(tetrahydrofuran-2-ylmethyl)piperazine-1-carbothioamide
  • 4-(4-fluorophenyl)sulfonyl-N-(2-tetrahydrofuranylmethyl)-1-piperazinecarbothioamide
  • 4-(4-fluorophenyl)sulfonyl-N-(tetrahydrofurfuryl)piperazine-1-carbothioamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0042 0.0036 0.0169
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0037 0.0025 0.0033
Leishmania major hypothetical protein, conserved 0.0066 0.01 0.0244
Loa Loa (eye worm) hypothetical protein 0.0096 0.0177 0.0404
Trypanosoma brucei DNA damage repair protein, putative 0.0056 0.0072 0.0176
Echinococcus granulosus sphingosine kinase 1 0.1703 0.437 0.437
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0021 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0062 0.0142
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0116 0.0229 0.0229
Echinococcus granulosus heat shock protein 0.0032 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0161 0.0161
Trypanosoma brucei phosphoglycerate kinase, putative 0.0204 0.046 0.1121
Plasmodium falciparum zinc finger protein, putative 0.0042 0.0035 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Schistosoma mansoni hypothetical protein 0.0187 0.0415 0.0415
Schistosoma mansoni endoplasmin 0.0032 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.004 0.0032 0.0032
Trypanosoma brucei heat shock protein, putative 0.0032 0.0012 0.0028
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.016 0.016
Echinococcus granulosus histone lysine methyltransferase setb 0.0155 0.0332 0.0332
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0012 0.0032
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0135 0.0287
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0135 0.031
Brugia malayi CXXC zinc finger family protein 0.0334 0.0799 0.3711
Echinococcus granulosus fetal alzheimer antigen falz 0.0091 0.0164 0.0164
Toxoplasma gondii ABC1 family protein 0.008 0.0135 0.0938
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0018 0.0128
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0056 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0142
Schistosoma mansoni microtubule-associated protein tau 0.1456 0.3725 0.3725
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0286 0.0655
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0145 0.0145
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0041 0.0033 0.0154
Giardia lamblia DINP protein human, muc B family 0.0194 0.0432 0.3101
Leishmania major sphingosine kinase A, B, putative 0.0066 0.01 0.0244
Schistosoma mansoni methyl-cpg binding protein mbd 0.0056 0.0073 0.0073
Brugia malayi hypothetical protein 0.0329 0.0786 0.365
Brugia malayi PHD-finger family protein 0.0031 0.0007 0.0033
Onchocerca volvulus 0.0099 0.0186 0.0999
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0225 0.0514 0.1253
Entamoeba histolytica hypothetical protein 0.0187 0.0415 0.0926
Leishmania major mitochondrial DNA polymerase beta 0.16 0.4101 1
Trypanosoma cruzi diacylglycerol kinase, putative 0.0066 0.01 0.0244
Echinococcus multilocularis lysine specific demethylase 5A 0.0098 0.0183 0.0183
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0034 0.0078
Echinococcus granulosus ATP dependent DNA helicase Q5 0.005 0.0057 0.0057
Mycobacterium tuberculosis Conserved protein 0.008 0.0135 0.0287
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0161 0.0161
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0187 0.0415 0.0415
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0068 0.0104 0.0482
Loa Loa (eye worm) glutaminase 2 0.0853 0.2153 0.4928
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0286 0.0286
Schistosoma mansoni Smad4 0.0033 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0072 0.0176
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0216 0.049 0.1098
Schistosoma mansoni acetyl-CoA synthetase 0.0037 0.0025 0.0025
Trypanosoma cruzi Sphingosine kinase 0.0066 0.01 0.0244
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0556 0.1378 0.6401
Brugia malayi hypothetical protein 0.0187 0.0415 0.1928
Brugia malayi nuclear receptor NHR-88 0.0052 0.0062 0.0288
Brugia malayi Bloom's syndrome protein homolog 0.0121 0.0242 0.1125
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0062 0.0288
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0216 0.049 0.1195
Schistosoma mansoni hypothetical protein 0.3861 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0117 0.0234 0.0234
Schistosoma mansoni ap endonuclease 0.0082 0.0142 0.0142
Giardia lamblia DNA damage repair protein 0.0056 0.0072 0.0474
Echinococcus multilocularis caspase 8 0.0028 0.00000001014 0.00000001014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0116 0.0229 0.0229
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0127 0.0259 0.1867
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0135 0.0255
Schistosoma mansoni blooms syndrome DNA helicase 0.0095 0.0176 0.0176
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0056 0.0056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0135 0.0135
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0187 0.0415 0.0415
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0177 0.0378
Brugia malayi Bromodomain containing protein 0.0129 0.0263 0.122
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0114 0.0226 0.0551
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0056
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0106 0.0204 0.148
Brugia malayi Bromodomain containing protein 0.0266 0.062 0.288
Loa Loa (eye worm) hypothetical protein 0.0147 0.031 0.071
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Brugia malayi MH1 domain containing protein 0.0033 0.0013 0.006
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0056 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0135 0.033
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0037 0.0025 0.0164
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0037 0.0025 0.0114
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0082 0.0142 0.0142
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0034 0.0034
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0013 0.0013
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.0095 0.0443
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0062 0.0062
Plasmodium falciparum acyl-CoA synthetase 0.0095 0.0175 0.1271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0104 0.0482
Schistosoma mansoni smad 0.0033 0.0013 0.0013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0117 0.0234 0.0234
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0216 0.049 0.049
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0062 0.0332
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0062 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.001 0.0071
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0175 0.0383 0.0383
Brugia malayi Disco-interacting protein 2 homolog 0.0041 0.0033 0.0153
Schistosoma mansoni cpg binding protein 0.0357 0.086 0.086
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0166 0.0361 0.2501
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0135 0.033
Schistosoma mansoni hypothetical protein 0.052 0.1284 0.1284
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0179 0.0394 0.0394
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.001 0.001
Echinococcus multilocularis protein patched 0.0041 0.0034 0.0034
Trichomonas vaginalis DNA helicase recq, putative 0.0121 0.0242 0.1125
Leishmania major DNA polymerase eta, putative 0.029 0.0683 0.1665
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0074 0.0074
Brugia malayi Endoplasmin precursor 0.0032 0.0012 0.0054
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0204 0.046 0.1121
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0041 0.0033 0.0033
Schistosoma mansoni alkaline phosphatase 0.0175 0.0383 0.0383
Echinococcus granulosus caspase 8 0.0028 0.00000001014 0.00000001014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0062 0.0288
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0135 0.0628
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0062 0.0288
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0225 0.0514 0.1253
Entamoeba histolytica phosphoglycerate kinase, putative 0.0556 0.1378 0.3136
Mycobacterium tuberculosis Conserved protein 0.1703 0.437 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0062 0.0062
Leishmania major DNA polymerase kappa, putative 0.0056 0.0072 0.0176
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0056 0.0299
Loa Loa (eye worm) hypothetical protein 0.004 0.0032 0.0073
Plasmodium vivax hypothetical protein, conserved 0.008 0.0135 0.0982
Schistosoma mansoni hypothetical protein 0.005 0.0058 0.0058
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0062 0.0142
Loa Loa (eye worm) hypothetical protein 0.008 0.0135 0.031
Brugia malayi PHD-finger family protein 0.0033 0.0014 0.0065
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0099 0.0186 0.1291
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.001 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0062 0.0288
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0041 0.0033 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0135 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0022 0.0102
Onchocerca volvulus 0.0329 0.0786 0.4214
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0162 0.0347
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0161 0.0161
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0056 0.0056
Trypanosoma brucei hypothetical protein, conserved 0.0066 0.01 0.0244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0062 0.0062
Onchocerca volvulus 0.0033 0.0014 0.0074
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0095 0.0175 0.0378
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0037 0.0025 0.0164
Trypanosoma cruzi ISWI complex protein 0.0031 0.0009 0.0022
Trichomonas vaginalis hypothetical protein 0.0036 0.0022 0.0102
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0135 0.0628
Loa Loa (eye worm) hypothetical protein 0.005 0.0057 0.0131
Mycobacterium ulcerans hypothetical protein 0.0056 0.0072 0.0109
Mycobacterium ulcerans phosphoglycerate kinase 0.0556 0.1378 0.3115
Entamoeba histolytica diacylglycerol kinase, putative 0.0066 0.01 0.0203
Schistosoma mansoni hypothetical protein 0.052 0.1284 0.1284
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0116 0.0229 0.0229
Brugia malayi exodeoxyribonuclease III family protein 0.0082 0.0142 0.066
Echinococcus granulosus GPCR family 2 0.0116 0.0229 0.0229
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0319 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0062 0.0288
Brugia malayi ImpB/MucB/SamB family protein 0.029 0.0683 0.3172
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0066 0.01 0.0694
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0039
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0078 0.013 0.013
Trichomonas vaginalis esterase, putative 0.008 0.0135 0.0628
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0062 0.0062
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.0142 0.066
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0062 0.0288
Schistosoma mansoni bromodomain containing protein 0.0227 0.052 0.052
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0135 0.033
Trichomonas vaginalis dullard protein, putative 0.0041 0.0033 0.0154
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0025 0.0114
Echinococcus multilocularis zinc finger protein 0.0085 0.0148 0.0148
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0037 0.0025 0.0033
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.0025 0.006
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.001 0.0075
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0062 0.0062
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0145 0.0145
Brugia malayi hypothetical protein 0.0122 0.0245 0.114
Schistosoma mansoni DNA polymerase IV / kappa 0.0056 0.0072 0.0072
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0365 0.088 0.2013
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0002 0.0005
Entamoeba histolytica acyl-coA synthetase, putative 0.0127 0.0259 0.0568
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0041 0.0033 0.024
Trypanosoma brucei DNA damage repair protein, putative 0.0056 0.0072 0.0176
Leishmania major phosphoglycerate kinase C, glycosomal 0.0556 0.1378 0.3361
Echinococcus multilocularis disco interacting protein 2 0.0046 0.0046 0.0046
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.007 0.0136
Echinococcus granulosus disco interacting protein 2 0.0046 0.0046 0.0046
Loa Loa (eye worm) histone methyltransferase 0.0096 0.0177 0.0406
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0175 0.0383 0.0383
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0057 0.0263
Trypanosoma cruzi Sphingosine kinase 0.0066 0.01 0.0244
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0062 0.0332
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0037 0.0025 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0259 0.054
Echinococcus multilocularis heat shock protein 90 0.0032 0.0012 0.0012
Echinococcus granulosus ceramide kinase 0.0066 0.01 0.01
Brugia malayi RNA, U transporter 1 0.0082 0.014 0.0651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0062 0.0142
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.0727 0.1664
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0025 0.0056
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0062 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0013 0.003
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0066 0.01 0.0465
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0057 0.0263
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0028 0.0001 0.0006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0127 0.0259 0.0568
Loa Loa (eye worm) hypothetical protein 0.016 0.0344 0.0788
Onchocerca volvulus Huntingtin homolog 0.0122 0.0245 0.1316
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.025 0.0578 0.1323
Trypanosoma cruzi DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Loa Loa (eye worm) hypothetical protein 0.005 0.0058 0.0133
Onchocerca volvulus Ceramide kinase 1 homolog 0.0066 0.01 0.0537
Brugia malayi Importin beta-1 subunit 0.0029 0.0002 0.001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0757 0.1903 0.4639
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0009 0.0042
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0039 0.0039
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0556 0.1378 0.3361
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0025 0.0114
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.001 0.0025
Trypanosoma cruzi DNA polymerase eta, putative 0.029 0.0683 0.1665
Echinococcus granulosus importin subunit beta 1 0.0029 0.0002 0.0002
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0319 0.0319
Schistosoma mansoni phosphoglycerate kinase 0.0556 0.1378 0.1378
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0066 0.01 0.0694
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Schistosoma mansoni hypothetical protein 0.004 0.003 0.003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.025 0.0578 0.0578
Echinococcus multilocularis GPCR, family 2 0.0116 0.0229 0.0229
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0012 0.0028
Schistosoma mansoni ap endonuclease 0.0082 0.0142 0.0142
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0034 0.0034
Schistosoma mansoni SET domain protein 0.0033 0.0014 0.0014
Brugia malayi Phosphoglycerate kinase 0.0204 0.046 0.2135
Echinococcus granulosus snurportin 1 0.0307 0.0727 0.0727
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.1135 0.1135
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0179 0.0394 0.0902
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0056 0.0056
Echinococcus multilocularis ceramide kinase 0.0066 0.01 0.01
Brugia malayi latrophilin 2 splice variant baaae 0.025 0.0578 0.2685
Schistosoma mansoni hypothetical protein 0.0316 0.0752 0.0752
Brugia malayi diacylglycerol kinase 0.0066 0.01 0.0465
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0025 0.006
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0025 0.0114
Entamoeba histolytica recQ family helicase, putative 0.0065 0.0095 0.0192
Loa Loa (eye worm) RecQ helicase 0.0121 0.0242 0.0554
Mycobacterium tuberculosis Possible penicillin-binding protein 0.051 0.1257 0.286
Loa Loa (eye worm) hypothetical protein 0.0099 0.0186 0.0425
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0002 0.0002
Schistosoma mansoni sphingoid long chain base kinase 0.1703 0.437 0.437
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0033 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0062 0.0142
Plasmodium falciparum DNA repair protein REV1, putative 0.0056 0.0072 0.0523
Echinococcus granulosus mixed lineage leukemia protein mll 0.0078 0.013 0.013
Brugia malayi MH2 domain containing protein 0.0033 0.0013 0.006
Brugia malayi beta-lactamase family protein 0.008 0.0135 0.0628
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0147 0.031 0.071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0653 0.1632 0.3734
Echinococcus multilocularis tumor protein p63 0.0677 0.1694 0.1694
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0155 0.0332 0.0332
Trichomonas vaginalis rotamase, putative 0.0036 0.0021 0.0096
Loa Loa (eye worm) hypothetical protein 0.0066 0.01 0.0229
Trypanosoma brucei heat shock protein, putative 0.0032 0.0012 0.0028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0179 0.0394 0.0394
Brugia malayi CHE-14 protein 0.0041 0.0034 0.0159
Loa Loa (eye worm) hypothetical protein 0.0155 0.0332 0.0759
Trypanosoma brucei unspecified product 0.0123 0.0249 0.0608
Echinococcus granulosus tumor protein p63 0.0677 0.1694 0.1694
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0034 0.0159
Trypanosoma brucei phosphoglycerate kinase 0.0204 0.046 0.1121
Mycobacterium ulcerans hypothetical protein 0.0843 0.2126 0.4836
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0062 0.0062
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0082 0.0142 0.0347
Schistosoma mansoni hypothetical protein 0.0067 0.0103 0.0103
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0066 0.01 0.0229
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0216 0.049 0.049
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.0477 0.0477
Toxoplasma gondii hypothetical protein 0.0029 0.0002 0.0015
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0319 0.1481
Mycobacterium ulcerans hypothetical protein 0.0127 0.0259 0.054
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0161 0.0348 0.0348
Echinococcus granulosus transcription factor Dp 1 0.0125 0.0253 0.0253
Plasmodium falciparum diacylglycerol kinase, putative 0.0066 0.01 0.0727
Loa Loa (eye worm) Smad1 0.0033 0.0013 0.003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.018 0.018
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0025 0.006
Echinococcus granulosus geminin 0.052 0.1284 0.1284
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0066 0.01 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0062 0.0142
Loa Loa (eye worm) hypothetical protein 0.0137 0.0284 0.0649
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0056 0.0056
Mycobacterium ulcerans lipase LipD 0.008 0.0135 0.0255
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0021 0.0096
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0082 0.0142 0.0347
Schistosoma mansoni hypothetical protein 0.004 0.003 0.003
Echinococcus multilocularis protein dispatched 1 0.0047 0.0049 0.0049
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.005 0.0057 0.0266
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0401
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0062 0.0288
Brugia malayi Probable ClpP-like protease 0.0083 0.0145 0.0672
Schistosoma mansoni hypothetical protein 0.0307 0.0727 0.0727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0018 0.0016
Onchocerca volvulus 0.008 0.0135 0.0725
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0012 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0046 0.0048 0.0048
Trypanosoma brucei heat shock protein, putative 0.0032 0.0012 0.0028
Loa Loa (eye worm) hypothetical protein 0.008 0.0135 0.031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0238 0.0548 0.2545
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0082 0.0142 0.0302
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0142
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0259 0.0632
Leishmania major hypothetical protein, conserved 0.0066 0.01 0.0244
Onchocerca volvulus 0.0099 0.0186 0.0996
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0007 0.005
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0142
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0074 0.0074
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0194 0.0432 0.1054
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0041 0.0033 0.0229
Echinococcus granulosus CTD small phosphatase protein like 0.0041 0.0033 0.0033
Trichomonas vaginalis sphingosine kinase, putative 0.0066 0.01 0.0465
Onchocerca volvulus 0.0066 0.01 0.0537
Leishmania major hypothetical protein, conserved 0.008 0.0135 0.033
Trypanosoma cruzi DNA damage repair protein, putative 0.0056 0.0072 0.0176
Schistosoma mansoni hypothetical protein 0.0066 0.01 0.01
Schistosoma mansoni zinc finger protein 0.005 0.0058 0.0058
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.007 0.007
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0259 0.1203
Trichomonas vaginalis DNA polymerase eta, putative 0.0238 0.0548 0.2545
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.0287 0.0701
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Brugia malayi Calcitonin receptor-like protein seb-1 0.0365 0.088 0.4085
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0041 0.0033 0.024
Trypanosoma brucei unspecified product 0.0223 0.051 0.1243
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0401
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0091 0.0164 0.0164
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0062 0.0288
Loa Loa (eye worm) hypothetical protein 0.0329 0.0786 0.1799
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0186 0.0186
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0025 0.0114
Schistosoma mansoni glutaminase 0.0853 0.2153 0.2153
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0025 0.0056
Echinococcus granulosus intestinal type alkaline phosphatase 0.0175 0.0383 0.0383
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.001 0.0025
Trypanosoma brucei ISWI complex protein 0.005 0.0058 0.014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0062 0.0288
Brugia malayi hypothetical protein 0.0066 0.01 0.0465
Plasmodium falciparum phd finger protein, putative 0.0031 0.0007 0.0052
Onchocerca volvulus 0.008 0.0135 0.0725
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0041 0.0033 0.0154
Entamoeba histolytica deoxycytidyl transferase, putative 0.0179 0.0394 0.0878
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0186 0.0186
Onchocerca volvulus 0.008 0.0135 0.0725
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0062 0.0062
Echinococcus granulosus lysine specific demethylase 5A 0.0121 0.0243 0.0243
Trypanosoma brucei heat shock protein, putative 0.0032 0.0012 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0259 0.0632
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0057 0.0057
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0007 0.0007
Echinococcus granulosus phosphoglycerate kinase 1 0.0556 0.1378 0.1378
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0037 0.0025 0.003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0194 0.0432 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0216 0.049 0.049
Echinococcus multilocularis expressed conserved protein 0.009 0.0161 0.0161
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0365 0.088 0.2013
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0072 0.0176
Plasmodium falciparum heat shock protein 90 0.0032 0.0012 0.0084
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0204 0.046 0.1121
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.0025 0.0033
Leishmania major phosphoglycerate kinase B, cytosolic 0.0556 0.1378 0.3361
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0175 0.0383 0.0383
Onchocerca volvulus 0.0037 0.0025 0.0132
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Echinococcus granulosus cpg binding protein 0.0357 0.086 0.086
Loa Loa (eye worm) hypothetical protein 0.0122 0.0245 0.0562
Plasmodium vivax diacylglycerol kinase, putative 0.0066 0.01 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0056
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0027 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0121 0.0243 0.0243
Trypanosoma cruzi diacylglycerol kinase, putative 0.0066 0.01 0.0244
Schistosoma mansoni phosphoglycerate kinase 0.0556 0.1378 0.1378
Brugia malayi Pre-SET motif family protein 0.0653 0.1632 0.7578
Echinococcus multilocularis Smad4 0.0033 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0194 0.0432 0.1054
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0012 0.0028
Echinococcus multilocularis expressed protein 0.0036 0.0021 0.0021
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.007 0.0492
Echinococcus granulosus bloom syndrome protein 0.0121 0.0242 0.0242
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0127 0.0259 0.1867
Loa Loa (eye worm) PHD-finger family protein 0.0067 0.0103 0.0236
Onchocerca volvulus 0.0052 0.0062 0.0332
Trypanosoma brucei phosphoglycerate kinase 0.0556 0.1378 0.3361
Schistosoma mansoni hypothetical protein 0.004 0.003 0.003
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.0142 0.066
Toxoplasma gondii propionate-CoA ligase 0.0037 0.0025 0.0171
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.001 0.0025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0135 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0062 0.0288
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0041 0.0033 0.0081
Echinococcus granulosus expressed conserved protein 0.009 0.0161 0.0161
Leishmania major hypothetical protein, conserved 0.0041 0.0033 0.0081
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3349 0.8665 0.8665
Echinococcus granulosus expressed protein 0.0036 0.0021 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0135 0.0628
Onchocerca volvulus Huntingtin homolog 0.0122 0.0245 0.1316
Onchocerca volvulus 0.0049 0.0056 0.0299
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0041 0.0033 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.005 0.0057 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0062 0.0288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0078 0.013 0.013
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0081 0.0138 0.0954
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Schistosoma mansoni rotamase 0.0036 0.0021 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0062 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0162 0.0347
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0556 0.1378 1
Trichomonas vaginalis sphingosine kinase, putative 0.0066 0.01 0.0465
Echinococcus multilocularis muscleblind protein 0.0147 0.031 0.031
Leishmania major DNA damage repair protein, putative 0.0056 0.0072 0.0176
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0062 0.0062
Mycobacterium tuberculosis Conserved hypothetical protein 0.0843 0.2126 0.4853
Toxoplasma gondii diacylglycerol kinase, putative 0.0066 0.01 0.0694
Loa Loa (eye worm) hypothetical protein 0.0056 0.0074 0.0168
Echinococcus multilocularis geminin 0.052 0.1284 0.1284
Leishmania major diacylglycerol kinase, putative 0.0066 0.01 0.0244
Schistosoma mansoni patched 1 0.0041 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0556 0.1378 0.3154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0062 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Brugia malayi Phosphoglycerate kinase 0.0556 0.1378 0.6401
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0216 0.049 0.049
Trichomonas vaginalis bmru protein, putative 0.0066 0.01 0.0465
Onchocerca volvulus 0.0334 0.0799 0.4284
Echinococcus multilocularis cpg binding protein 0.0357 0.086 0.086
Brugia malayi mbt repeat family protein 0.0049 0.0056 0.0259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0286 0.0286
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0216 0.049 0.1121
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0018 0.0045
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.005 0.0057 0.0266
Brugia malayi jmjC domain containing protein 0.0161 0.0348 0.1615
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0122 0.0245 0.0562
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.001 0.0071
Schistosoma mansoni alkaline phosphatase 0.0175 0.0383 0.0383
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0074 0.0074
Brugia malayi jmjC domain containing protein 0.0121 0.0243 0.113
Loa Loa (eye worm) glutaminase 0.0853 0.2153 0.4928
Schistosoma mansoni diacylglycerol kinase theta 0.0066 0.01 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0062 0.0062
Toxoplasma gondii hypothetical protein 0.0089 0.0159 0.1105
Trichomonas vaginalis rotamase, putative 0.0035 0.0018 0.0086
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0216 0.049 0.049
Toxoplasma gondii exonuclease III APE 0.0082 0.0142 0.0985
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0066 0.01 0.01
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.007 0.011 0.0764
Brugia malayi Pre-SET motif family protein 0.0099 0.0186 0.0865
Echinococcus granulosus peregrin 0.0042 0.0036 0.0036
Brugia malayi SET domain containing protein 0.0038 0.0026 0.0121
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0145 0.1036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0162 0.0347
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0286 0.1329
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.16 0.4101 1
Echinococcus multilocularis Diacylglycerol kinase theta 0.0066 0.01 0.01
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0013 0.0013
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0037 0.0025 0.0179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0104 0.0482
Trichomonas vaginalis helicase, putative 0.0068 0.0104 0.0482
Loa Loa (eye worm) hypothetical protein 0.0069 0.0107 0.0244
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0259 0.1203
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.001 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0062 0.0288
Brugia malayi isocitrate dehydrogenase 0.0032 0.001 0.0048
Onchocerca volvulus Alhambra homolog 0.0031 0.0007 0.0038
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0062 0.0062
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0757 0.1903 0.4639
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0135 0.0287
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0066 0.01 0.0244
Loa Loa (eye worm) hypothetical protein 0.0125 0.0254 0.0582
Trypanosoma brucei unspecified product 0.0123 0.0249 0.0608
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0072 0.0176
Schistosoma mansoni heat shock protein 0.0032 0.0012 0.0012
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0175 0.0383 0.0383
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0049 0.0056 0.0056
Trypanosoma brucei chrX additional, unordered contigs 0.0056 0.0072 0.0176
Plasmodium vivax acyl-CoA synthetase, putative 0.0095 0.0175 0.1271
Plasmodium vivax acetyl-CoA synthetase, putative 0.0037 0.0025 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0007 0.0052
Echinococcus multilocularis phosphoglycerate kinase 1 0.0556 0.1378 0.1378
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0638 0.159 0.159
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0065 0.0095 0.0233
Schistosoma mansoni DNA helicase recq1 0.005 0.0057 0.0057
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.005 0.0057 0.0415
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0556 0.1378 0.3138
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0225 0.0514 0.1253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0104 0.0482
Onchocerca volvulus 0.0037 0.0025 0.0132
Echinococcus multilocularis smad 0.0033 0.0013 0.0013
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0049 0.0056 0.0056
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0025 0.006
Brugia malayi heat shock protein 90 0.0032 0.0012 0.0054
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0037 0.0025 0.0033
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Brugia malayi steroid hormone receptor 0.0052 0.0062 0.0288
Trypanosoma brucei Sphingosine kinase 0.0066 0.01 0.0244
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.1135 0.1135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0162 0.0347
Echinococcus multilocularis dna polymerase eta 0.029 0.0683 0.0683
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0007 0.0007
Plasmodium vivax diacylglycerol kinase, putative 0.0066 0.01 0.0727
Loa Loa (eye worm) beta-lactamase 0.008 0.0135 0.031
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0012 0.0084
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0259 0.0632
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0177 0.0177
Plasmodium falciparum importin beta, putative 0.0029 0.0002 0.0015
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.001 0.0075
Loa Loa (eye worm) hypothetical protein 0.0127 0.0259 0.0593
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0025 0.0033
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0556 0.1378 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.005 0.0057 0.0131
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0025 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0046 0.0046 0.0046
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0135 0.0287
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0231 0.053 0.1213
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0225 0.0514 0.1253
Trypanosoma brucei heat shock protein, putative 0.0032 0.0012 0.0028
Trypanosoma brucei mitochondrial DNA polymerase beta 0.16 0.4101 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0062 0.0062
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0556 0.1378 0.6401
Loa Loa (eye worm) hypothetical protein 0.029 0.0683 0.1563
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.0011 0.0002
Mycobacterium ulcerans hypothetical protein 0.008 0.0135 0.0255
Loa Loa (eye worm) hypothetical protein 0.0049 0.0056 0.0128
Plasmodium falciparum diacylglycerol kinase, putative 0.0066 0.01 0.0727
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0062 0.0062
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.00000001014 0.00000001014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0082 0.0142 0.0347
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0175 0.0347
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0089 0.0159 0.1157
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0142
Trypanosoma cruzi DNA polymerase eta, putative 0.0166 0.0361 0.088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0286 0.0286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0062 0.0142
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0025 0.0033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0082 0.0142 0.0347
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Schistosoma mansoni hypothetical protein 0.0116 0.0229 0.0229
Trypanosoma cruzi DNA damage repair protein, putative 0.0056 0.0072 0.0176
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Mycobacterium tuberculosis Conserved protein 0.008 0.0135 0.0287
Trichomonas vaginalis dullard protein, putative 0.0041 0.0033 0.0154
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0027 0.0147
Entamoeba histolytica diacylglycerol kinase, putative 0.0066 0.01 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0062 0.0288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0096 0.0177 0.0177
Schistosoma mansoni jumonji domain containing protein 0.0141 0.0294 0.0294
Schistosoma mansoni diacylglycerol kinase theta 0.0066 0.01 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0041 0.0033 0.0075
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0062 0.0062
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0041 0.0033 0.0189
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0099 0.0186 0.0186
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0145 0.105
Schistosoma mansoni hypothetical protein 0.0091 0.0164 0.0164
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0135 0.0287
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0065 0.0095 0.0233
Leishmania major DNA polymerase kappa, putative 0.0194 0.0432 0.1054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0116 0.0229 0.0229
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0037 0.0025 0.0171
Entamoeba histolytica hypothetical protein, conserved 0.1703 0.437 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0104 0.0482
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0216 0.049 0.2276
Brugia malayi nuclear hormone receptor 0.0052 0.0062 0.0288
Echinococcus granulosus zinc finger protein 0.0085 0.0148 0.0148
Echinococcus multilocularis peregrin 0.0042 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.0287 0.0701
Echinococcus multilocularis microtubule associated protein 2 0.1456 0.3725 0.3725
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.01 0.0244
Trichomonas vaginalis bmru protein, putative 0.0066 0.01 0.0465
Trypanosoma brucei DNA polymerase IV, putative 0.0223 0.051 0.1243
Brugia malayi beta-lactamase 0.008 0.0135 0.0628
Entamoeba histolytica diacylglycerol kinase, putative 0.0066 0.01 0.0203
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0177 0.0177
Entamoeba histolytica hypothetical protein 0.0187 0.0415 0.0926
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0057 0.0411
Schistosoma mansoni myst-related protein 0.0042 0.0035 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0238 0.0548 0.1336
Echinococcus multilocularis 0.0041 0.0033 0.0033
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0204 0.046 0.1121
Schistosoma mansoni smad1 5 8 and 0.0033 0.0013 0.0013
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0066 0.01 0.01
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0007 0.005
Plasmodium vivax importin-beta 2, putative 0.0029 0.0002 0.0015
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0757 0.1903 0.4639
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0556 0.1378 0.9552
Schistosoma mansoni DNA polymerase eta 0.029 0.0683 0.0683
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0041 0.0033 0.0154
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.1135 0.1135
Trypanosoma cruzi ISWI complex protein 0.005 0.0058 0.014
Trypanosoma brucei heat shock protein, putative 0.0032 0.0012 0.0028
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0155 0.0332 0.0332
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0082 0.014 0.1017
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0216 0.049 0.1195
Mycobacterium ulcerans glutaminase 0.0853 0.2153 0.4899
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.001 0.001
Trypanosoma brucei heat shock protein, putative 0.0032 0.0012 0.0028
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0037 0.0025 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0001 0.0006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0288 0.0288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0104 0.0482
Schistosoma mansoni jumonji/arid domain-containing protein 0.0121 0.0243 0.0243
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.0025 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0062 0.0062
Trypanosoma brucei DNA polymerase eta, putative 0.029 0.0683 0.1665
Brugia malayi MH2 domain containing protein 0.0483 0.1188 0.5515
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0259 0.1203
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0066 0.01 0.01
Loa Loa (eye worm) latrophilin receptor protein 2 0.0116 0.0229 0.0523
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0078
Echinococcus granulosus neuropeptide s receptor 0.0463 0.1135 0.1135
Schistosoma mansoni hypothetical protein 0.0116 0.0229 0.0229
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0007 0.0016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.0142 0.1031
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.005 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0401
Loa Loa (eye worm) hypothetical protein 0.0116 0.0229 0.0523
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0145 0.0145
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0066 0.01 0.0244
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0062 0.0332
Loa Loa (eye worm) MH2 domain-containing protein 0.0483 0.1188 0.2718
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0082 0.0142 0.0325
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0096 0.0177 0.0177
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0066 0.01 0.0244
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0056 0.0056
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.001 0.0024
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0204 0.046 0.1121
Schistosoma mansoni smad1 5 8 and 0.0033 0.0013 0.0013
Echinococcus multilocularis muscleblind protein 1 0.0147 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Echinococcus multilocularis bloom syndrome protein 0.0121 0.0242 0.0242
Onchocerca volvulus 0.0127 0.0259 0.1389
Echinococcus granulosus Diacylglycerol kinase theta 0.0066 0.01 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0259 0.054
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0057 0.0392
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Giardia lamblia Phosphoglycerate kinase 0.0556 0.1378 1
Trypanosoma brucei diacylglycerol kinase, putative 0.0066 0.01 0.0244
Schistosoma mansoni hypothetical protein 0.004 0.003 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0135 0.0628
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0284 0.0284
Schistosoma mansoni cpg binding protein 0.0357 0.086 0.086
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0022 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0021 0.0096
Loa Loa (eye worm) hypothetical protein 0.0033 0.0014 0.0032
Trypanosoma brucei phosphoglycerate kinase 0.0556 0.1378 0.3361
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0365 0.088 0.4085
Loa Loa (eye worm) MBCTL1 0.0056 0.0074 0.0168
Schistosoma mansoni importin beta-1 0.0029 0.0002 0.0002
Loa Loa (eye worm) oxidoreductase 0.0037 0.0025 0.0056
Loa Loa (eye worm) hypothetical protein 0.0083 0.0145 0.0331
Loa Loa (eye worm) hypothetical protein 0.1703 0.437 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0114 0.0226 0.0551
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0025 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0082 0.0142 0.0142
Schistosoma mansoni terminal deoxycytidyl transferase 0.0179 0.0394 0.0394
Schistosoma mansoni hypothetical protein 0.0116 0.0229 0.0229
Brugia malayi MH1 domain containing protein 0.0033 0.0013 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0009 0.0042
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0056 0.0056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0127 0.0259 0.0571
Loa Loa (eye worm) hypothetical protein 0.008 0.0135 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Plasmodium vivax endoplasmin, putative 0.0032 0.0012 0.0084
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0179 0.0394 0.0394
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.16 0.4101 1
Plasmodium vivax SET domain protein, putative 0.0099 0.0186 0.1351
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0127 0.0259 0.054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0155 0.0332 0.0332
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0025 0.0114
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0091 0.0164 0.0164
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0002 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0274 0.0642 0.1566
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0012 0.008
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0056 0.0056
Loa Loa (eye worm) CXXC zinc finger family protein 0.0334 0.0799 0.1829
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.001 0.001
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0284 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Treponema pallidum phosphoglycerate kinase 0.0556 0.1378 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0286 0.0286
Entamoeba histolytica hypothetical protein 0.0187 0.0415 0.0926
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0056 0.0072 0.05
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0065 0.0095 0.0233
Loa Loa (eye worm) hypothetical protein 0.0066 0.01 0.0229
Trypanosoma brucei ISWI complex protein 0.0031 0.0009 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Trichomonas vaginalis dullard protein, putative 0.0041 0.0033 0.0154
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0145 0.0276
Onchocerca volvulus 0.009 0.0161 0.0863
Echinococcus multilocularis snurportin 1 0.0307 0.0727 0.0727
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0037 0.0025 0.006
Plasmodium falciparum phosphoglycerate kinase 0.0556 0.1378 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0082 0.0142 0.0984
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0025 0.006
Onchocerca volvulus 0.0041 0.0033 0.0176
Schistosoma mansoni DNA helicase recq5 0.005 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0187 0.0415 0.0926
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0068 0.0104 0.0482
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0175 0.0383 0.0383
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0062 0.0062
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0012 0.0028
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0145 0.0021
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0012 0.008
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Schistosoma mansoni zinc finger protein 0.0085 0.0148 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.0287 0.0701
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0041 0.0033 0.0154
Echinococcus granulosus methyl CpG binding domain protein 2 0.0056 0.0073 0.0073
Mycobacterium tuberculosis Diacylglycerol kinase 0.0066 0.01 0.0206
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0161 0.0747
Mycobacterium ulcerans diacylglycerol kinase 0.0066 0.01 0.0174
Entamoeba histolytica diacylglycerol kinase, putative 0.0066 0.01 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Brugia malayi Smad1 0.0033 0.0013 0.006
Leishmania major DNA polymerase eta, putative 0.0166 0.0361 0.088
Echinococcus granulosus heat shock protein 90 0.0032 0.0012 0.0012
Loa Loa (eye worm) bromodomain containing protein 0.0061 0.0087 0.0199
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0082 0.0142 0.03
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0088 0.0156 0.0156
Brugia malayi MH2 domain containing protein 0.0033 0.0013 0.006
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0025 0.0114
Trypanosoma cruzi ISWI complex protein 0.005 0.0058 0.014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0082 0.0142 0.0271
Brugia malayi ecdysteroid receptor 0.0052 0.0062 0.0288
Loa Loa (eye worm) hypothetical protein 0.0312 0.0742 0.1699
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0037 0.0025 0.0033
Onchocerca volvulus 0.0743 0.1865 1
Brugia malayi Eye-specific diacylglycerol kinase 0.0066 0.01 0.0465
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0074 0.0074
Brugia malayi Diacylglycerol kinase protein 2 0.0066 0.01 0.0465
Echinococcus granulosus alkaline phosphatase 0.0175 0.0383 0.0383
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0066 0.01 0.0465
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0116 0.0229 0.1061
Loa Loa (eye worm) hypothetical protein 0.009 0.0161 0.0368
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0025 0.0114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0127 0.0259 0.0571
Schistosoma mansoni coup transcription factor 0.0052 0.0062 0.0062
Mycobacterium ulcerans DNA polymerase IV 0.0238 0.0548 0.1204
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0039 0.0039
Mycobacterium leprae conserved hypothetical protein 0.008 0.0135 0.0968
Toxoplasma gondii hypothetical protein 0.0258 0.06 0.4161
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0145 0.105
Schistosoma mansoni sphingosine kinase A B 0.1703 0.437 0.437
Giardia lamblia Sgs1 DNA helicase, putative 0.005 0.0057 0.0365
Entamoeba histolytica hypothetical protein 0.0042 0.0035 0.0055
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.008 0.0135 0.031
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0037 0.0025 0.0025
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0062 0.0142
Loa Loa (eye worm) transcription factor SMAD2 0.0483 0.1188 0.2718
Schistosoma mansoni bromodomain containing protein 0.0035 0.0017 0.0017
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0012 0.0028
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0013 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0286 0.0286
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0145 0.0276
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0041 0.0033 0.0033
Schistosoma mansoni methyl-cpg binding protein mbd 0.0056 0.0073 0.0073
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0037 0.0025 0.0033
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0066 0.01 0.01
Onchocerca volvulus 0.0037 0.0025 0.0132
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0142
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0204 0.046 0.1121
Echinococcus multilocularis heat shock protein 0.0032 0.0012 0.0012
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0041 0.0033 0.024
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0259 0.054
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0062 0.0062
Schistosoma mansoni heat shock protein 0.0032 0.0012 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0068 0.0104 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0062 0.0288
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0012 0.0028
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0401
Brugia malayi Latrophilin receptor protein 2 0.0116 0.0229 0.1061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0062 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0286 0.0286
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0243 0.0557
Loa Loa (eye worm) hypothetical protein 0.0066 0.01 0.0229
Treponema pallidum exodeoxyribonuclease (exoA) 0.0082 0.0142 0.1018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0135 0.0287
Schistosoma mansoni smad1 5 8 and 0.0033 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.008 0.0135 0.031
Echinococcus granulosus dna polymerase eta 0.029 0.0683 0.0683
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0062 0.0288
Trichomonas vaginalis set domain proteins, putative 0.0743 0.1865 0.8661
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0041 0.0033 0.0154
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0034 0.0034
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0556 0.1378 0.9552
Schistosoma mansoni cpg binding protein 0.0334 0.0799 0.0799
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0177 0.082
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0074 0.0341
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0099 0.0186 0.0186
Echinococcus multilocularis alkaline phosphatase 0.0175 0.0383 0.0383
Plasmodium vivax phosphoglycerate kinase, putative 0.0556 0.1378 1
Schistosoma mansoni myst-related protein 0.0042 0.0035 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0286 0.0286
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0025 0.0033
Chlamydia trachomatis phosphoglycerate kinase 0.0556 0.1378 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0018 0.0045
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0057 0.0392
Trypanosoma brucei heat shock protein, putative 0.0032 0.0012 0.0028
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0062 0.0288
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Leishmania major heat shock protein 83-1 0.0032 0.0012 0.0028
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0145 0.1036
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0104 0.0482
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0025 0.006
Loa Loa (eye worm) ceramide kinase 0.0066 0.01 0.0229
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0062 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0238 0.0548 0.1336
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0025 0.0164
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0127 0.0259 0.054
Loa Loa (eye worm) diacylglycerol kinase 2 0.0066 0.01 0.0229
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0135 0.0135
Brugia malayi glutaminase DH11.1 0.0853 0.2153 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0216 0.049 0.1195
Mycobacterium ulcerans hypothetical protein 0.1703 0.437 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0012 0.0028
Brugia malayi beta-lactamase family protein 0.008 0.0135 0.0628
Schistosoma mansoni transcription factor LCR-F1 0.0187 0.0415 0.0415
Trichomonas vaginalis diacylglycerol kinase, putative 0.0066 0.01 0.0465
Trypanosoma brucei DNA polymerase IV, putative 0.0238 0.0548 0.1336
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0037 0.0025 0.0171
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0002 0.0015
Schistosoma mansoni hypothetical protein 0.0116 0.0229 0.0229
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0012 0.0028
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0556 0.1378 0.3361
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0066 0.01 0.0465
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0161 0.0348 0.0348
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0062 0.0062
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0216 0.049 0.1195
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0012 0.0027
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.0142 0.1031
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0095 0.0175 0.0247
Echinococcus granulosus Diacylglycerol kinase zeta 0.0066 0.01 0.01
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0041 0.0033 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0078 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0142
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0062 0.0062
Brugia malayi polk-prov protein 0.0114 0.0226 0.1049
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0092 0.0211
Brugia malayi Muscleblind-like protein 0.0147 0.031 0.144
Loa Loa (eye worm) hypothetical protein 0.0127 0.0259 0.0593
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.0477 0.0477
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.001 0.001
Brugia malayi mbt repeat family protein 0.0049 0.0056 0.0259
Echinococcus multilocularis sphingosine kinase 1 0.1703 0.437 0.437
Mycobacterium leprae Probable lipase LipE 0.008 0.0135 0.0968
Echinococcus multilocularis dna polymerase kappa 0.0238 0.0548 0.0548
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0012 0.0054
Brugia malayi Ceramide kinase 0.0066 0.01 0.0465
Loa Loa (eye worm) hypothetical protein 0.0127 0.0259 0.0593
Loa Loa (eye worm) hypothetical protein 0.008 0.0135 0.031
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0142
Mycobacterium ulcerans beta-lactamase 0.008 0.0135 0.0255
Loa Loa (eye worm) acetyltransferase 0.015 0.0319 0.073
Brugia malayi F/Y-rich N-terminus family protein 0.0111 0.0217 0.1006
Echinococcus multilocularis dnaJ subfamily B 0.3861 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0127 0.0259 0.054
Echinococcus granulosus ATP dependent DNA helicase Q1 0.005 0.0057 0.0057
Brugia malayi diacylglycerol kinase 0.0066 0.01 0.0465
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0135 0.0287
Loa Loa (eye worm) endoplasmin 0.0032 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0114 0.0226 0.0517
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.005 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0041 0.0033 0.0076
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0145 0.1003
Mycobacterium ulcerans DNA polymerase IV 0.0238 0.0548 0.1204
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0062 0.0062
Echinococcus granulosus microtubule associated protein 2 0.1456 0.3725 0.3725
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.01 0.0465
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0135 0.0287
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0145 0.1003
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0066 0.01 0.01
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0062 0.0062
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0018 0.0045
Leishmania major hypothetical protein, conserved 0.005 0.0058 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0009 0.0042
Toxoplasma gondii histone lysine methyltransferase SET1 0.0581 0.1443 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.005 0.0057 0.0396
Onchocerca volvulus 0.0037 0.0025 0.0132
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0062 0.0062
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0027 0.0198
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0204 0.046 0.1121
Trichomonas vaginalis diacylglycerol kinase, putative 0.0066 0.01 0.0465
Trichomonas vaginalis DNA helicase recq1, putative 0.0121 0.0242 0.1125
Schistosoma mansoni endoplasmin 0.0032 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.008 0.0135 0.0287
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.001 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0127 0.0259 0.0568
Echinococcus granulosus smad 0.0033 0.0013 0.0013
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0127 0.0259 0.054
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0062 0.0062
Brugia malayi ImpB/MucB/SamB family protein 0.0179 0.0394 0.1831
Trichomonas vaginalis glutaminase, putative 0.0853 0.2153 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.0394 0.0881
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0013 0.0013
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0007 0.0007
Plasmodium vivax DNA repair protein REV1, putative 0.0056 0.0072 0.0523
Echinococcus granulosus dna polymerase kappa 0.0238 0.0548 0.0548
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0072 0.0176
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.007 0.0136
Brugia malayi PHD-finger family protein 0.0102 0.0193 0.0897
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0135 0.0255
Echinococcus granulosus Smad4 0.0033 0.0013 0.0013
Leishmania major diacylglycerol kinase-like protein 0.0066 0.01 0.0244
Echinococcus granulosus muscleblind protein 0.0147 0.031 0.031
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0018 0.0045
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0401
Echinococcus multilocularis transcription factor Dp 1 0.0125 0.0253 0.0253
Brugia malayi Isocitrate dehydrogenase 0.0032 0.001 0.0048

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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