Detailed information for compound 1561275

Basic information

Technical information
  • TDR Targets ID: 1561275
  • Name: 4-fluoro-N'-[4-(3-methylphenoxy)butanoyl]benz ohydrazide
  • MW: 330.353 | Formula: C18H19FN2O3
  • H donors: 2 H acceptors: 2 LogP: 3.13 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NNC(=O)c1ccc(cc1)F)CCCOc1cccc(c1)C
  • InChi: 1S/C18H19FN2O3/c1-13-4-2-5-16(12-13)24-11-3-6-17(22)20-21-18(23)14-7-9-15(19)10-8-14/h2,4-5,7-10,12H,3,6,11H2,1H3,(H,20,22)(H,21,23)
  • InChiKey: KUKLKHUWSBUQAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-fluoro-N'-[4-(3-methylphenoxy)-1-oxobutyl]benzohydrazide
  • ZINC06510401
  • T5381275

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0874 0.6246 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0093 0.0138
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0093 0.045
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Schistosoma mansoni cpg binding protein 0.0031 0.0183 0.0183
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.07 0.0686
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Brugia malayi hypothetical protein 0.0008 0.0014 0.0033
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0049 0.0239
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0356 0.0342
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0126 0.061
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0008 0.0014 0.007
Echinococcus multilocularis solute carrier family 22 0.001 0.0028 0.0014
Trypanosoma brucei glucose transporter, putative 0.001 0.0028 0.0138
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Trichomonas vaginalis glucose transporter, putative 0.001 0.0028 0.0035
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0126 0.0123
Brugia malayi 6-phosphofructokinase 0.0112 0.0762 0.1715
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0191 0.0429
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0225 0.0211
Toxoplasma gondii facilitative glucose transporter GT1 0.001 0.0028 0.0407
Brugia malayi oxidoreductase 0.0008 0.0014 0.0033
Mycobacterium ulcerans carveol-like dehydrogenase 0.0008 0.0014 0.0048
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0452 0.0714
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Leishmania major cytochrome p450-like protein 0.0013 0.0049 0.0239
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0356 0.0356
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.007
Brugia malayi phosphofructokinase 0.0112 0.0762 0.1715
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0014 0.007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0028 0.0014
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0014 0.0048
Trichomonas vaginalis glucose transporter, putative 0.001 0.0028 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0577 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0028 0.0035
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0189
Trypanosoma brucei trypanothione reductase 0.0037 0.0222 0.1076
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0014 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0762 0.121
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0762 0.1199
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Brugia malayi Sugar transporter family protein 0.001 0.0028 0.0064
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0452 0.2193
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0626 0.2028
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.007
Brugia malayi intermediate filament protein 0.0027 0.0151 0.0341
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.0781 0.0768
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0953 0.4626
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0139 0.0673
Leishmania major pyruvate kinase 0.0032 0.0191 0.0925
Loa Loa (eye worm) RecQ helicase 0.0022 0.0116 0.0261
Leishmania major hypothetical protein, conserved 0.0025 0.0139 0.0673
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1066 0.3487
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0191 0.0429
Echinococcus granulosus Solute carrier family 22 5 0.103 0.7371 0.7367
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.0762 0.0748
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0014 0.007
Trypanosoma brucei protein kinase, putative 0.0103 0.07 0.3394
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.005 0.024
Brugia malayi hypothetical protein 0.001 0.0028 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0028 0.0035
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0028 0.0035
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Echinococcus multilocularis Sugar transporter ERD6 protein 0.001 0.0028 0.0014
Echinococcus granulosus solute carrier family 22 0.001 0.0028 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0093 0.045
Chlamydia trachomatis pyruvate kinase 0.0032 0.0191 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0014 0.0033
Echinococcus multilocularis GPCR, family 2 0.0019 0.0095 0.0081
Plasmodium falciparum thioredoxin reductase 0.0013 0.005 0.1097
Trypanosoma brucei glucose transporter, putative 0.001 0.0028 0.0138
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.07 0.1576
Leishmania major glucose transporter, lmgt2 0.001 0.0028 0.0138
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0065 0.1073
Brugia malayi pyruvate kinase 0.0007 0.0007 0.0016
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0191 0.0925
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.07 0.3394
Mycobacterium ulcerans dehydrogenase/reductase 0.0008 0.0014 0.0048
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0049 0.0111
Mycobacterium ulcerans integral membrane transport protein 0.001 0.0028 0.0094
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0039 0.0025
Trypanosoma cruzi hexose transporter, putative 0.001 0.0028 0.0138
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0407 0.0393
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Trypanosoma brucei glucose transporter 2A 0.001 0.0028 0.0138
Trypanosoma cruzi hexose transporter 0.001 0.0028 0.0138
Giardia lamblia Short-chain dehydrogenase, putative 0.0008 0.0014 0.0023
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.0762 0.2478
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0014 0.024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0874 0.6246 1
Schistosoma mansoni hypothetical protein 0.0019 0.0095 0.0095
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.005 0.3154
Loa Loa (eye worm) hypothetical protein 0.009 0.0605 0.1363
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.001 0.0028 0.1255
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0151 0.0341
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0452 0.0702
Giardia lamblia Hypothetical protein 0.0008 0.0014 0.0023
Schistosoma mansoni glucose transporter 0.001 0.0028 0.0028
Schistosoma mansoni pyruvate kinase 0.0032 0.0191 0.0191
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0175 0.2506
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.007
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0023 0.0518
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Leishmania major basic transcription factor 3a, putative 0.0069 0.0452 0.2193
Schistosoma mansoni cpg binding protein 0.0029 0.0171 0.0171
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0559 0.1806
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0247
Loa Loa (eye worm) glutathione reductase 0.0037 0.0222 0.0499
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0014 0.007
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0452 0.0714
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0114 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.006 0.0392 0.0882
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0191 0.0349
Onchocerca volvulus 0.001 0.0028 0.0028
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0191 0.0429
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.001 0.0028 0.0046
Onchocerca volvulus 0.001 0.0028 0.0028
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0008 0.0014 0.007
Giardia lamblia Hexose transporter 0.001 0.0028 0.0046
Loa Loa (eye worm) dehydrogenase 0.0008 0.0014 0.0033
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.005 0.1097
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0048 0.0033
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0014 0.0048
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0151 0.0341
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.0793 0.2617
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0095 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0025 0.0123
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.07 1
Leishmania major hypothetical protein, conserved 0.001 0.0028 0.0138
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0126 0.0369
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0452 0.2193
Giardia lamblia DINP protein human, muc B family 0.0019 0.0093 0.0148
Trypanosoma cruzi hexose transporter, putative 0.001 0.0028 0.0138
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0028 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0014 0.007
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0605 0.0591
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0014 0.007
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0139 0.1983
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.007
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0028 0.0014
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0222 0.0687
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0093 0.045
Trypanosoma brucei glucose transporter, putative 0.001 0.0028 0.0138
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0175 0.0281
Loa Loa (eye worm) phosphofructokinase 0.0112 0.0762 0.1715
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0028 0.0064
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0452 0.6461
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0014 0.007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0093 0.045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0356 0.0356
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0561 0.3995 0.6387
Brugia malayi glutathione reductase 0.0037 0.0222 0.0499
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.005 0.0708
Plasmodium falciparum pyruvate kinase 0.0032 0.0191 0.4216
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0271
Schistosoma mansoni sugar transporter 0.001 0.0028 0.0028
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0175 0.0258
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Schistosoma mansoni hypothetical protein 0.0019 0.0095 0.0095
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.07 0.0686
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.007
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0255 0.0573
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0.0014 0.0207
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.005 0.0069
Trypanosoma brucei glucose transporter, putative 0.001 0.0028 0.0138
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0175 0.2506
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0028 0.0035
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trichomonas vaginalis myo-inositol transporter, putative 0.001 0.0028 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0006 0.000000000043019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Schistosoma mansoni sugar transporter 0.001 0.0028 0.0028
Schistosoma mansoni DNA polymerase eta 0.0019 0.0093 0.0093
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0014 0.0033
Leishmania major 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.007
Schistosoma mansoni hypothetical protein 0.0041 0.0255 0.0255
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0222 0.3664
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.005 0.0819
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0561 0.3995 0.6391
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0014 0.007
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0035 0.002
Schistosoma mansoni pyruvate kinase 0.0017 0.0078 0.0078
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0078 0.1281
Schistosoma mansoni carbonyl reductase 0.0008 0.0014 0.0014
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0023 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0043 0.0045
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Giardia lamblia Pyruvate kinase 0.0032 0.0191 0.0305
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.07 0.0686
Loa Loa (eye worm) hypothetical protein 0.0041 0.0255 0.0573
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Trypanosoma brucei unspecified product 0.0013 0.0051 0.0247
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0023 0.0053
Plasmodium falciparum glutathione reductase 0.0013 0.005 0.1097
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0028 0.0035
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0126 0.0415
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.07 0.1111
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0271
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.012 0.017
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0126 0.0415
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.007
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.005 0.0164
Trypanosoma brucei unspecified product 0.0013 0.0051 0.0247
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0035 0.002
Schistosoma mansoni hypothetical protein 0.0019 0.0095 0.0095
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.0781 0.0768
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0175 0.892
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0014 0.0013
Onchocerca volvulus Putative transporter 0.001 0.0028 0.0028
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0207
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0053
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0028 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0333
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0953 0.4626
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0762 0.121
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.005 0.0035
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0559 0.1806
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0108 0.0737 0.166
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0014 0.0048
Plasmodium vivax sugar transporter, putative 0.001 0.0028 0.047
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0953 0.4626
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0626 0.2028
Leishmania major pyruvate kinase 0.0032 0.0191 0.0925
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0559 0.1806
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0553 0.054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.0341
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.005 0.3154
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0093 0.045
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.005 0.024
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0271
Onchocerca volvulus 0.001 0.0028 0.0028
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.005 0.024
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0049 0.0111
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.005 0.024
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0392 0.0882
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0175 0.0203
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0014 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Schistosoma mansoni pyruvate kinase 0.0032 0.0191 0.0191
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0222 0.1076
Schistosoma mansoni hypothetical protein 0.0011 0.0039 0.0039
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0014 0.0033
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0014 0.007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.012 0.0271
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0093 0.0078
Schistosoma mansoni glucose transport protein 0.001 0.0028 0.0028
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0014 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0271
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0093 0.0259
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.005 0.024
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0191 0.0295
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0052
Plasmodium falciparum hexose transporter 0.001 0.0028 0.0629
Echinococcus granulosus bloom syndrome protein 0.0022 0.0116 0.0102
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Leishmania major short chain dehydrogenase, putative 0.0008 0.0014 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0384 0.5489
Trypanosoma brucei oxidoreductase-like protein 0.0008 0.0014 0.007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0392 0.0882
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Echinococcus granulosus geminin 0.0205 0.1431 0.1419
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.005 0.024
Echinococcus granulosus dna polymerase kappa 0.0019 0.0093 0.0078
Trypanosoma brucei glucose transporter 1E 0.001 0.0028 0.0138
Echinococcus granulosus Sugar transporter ERD6 protein 0.001 0.0028 0.0014
Echinococcus multilocularis lamin 0.0027 0.0151 0.0137
Loa Loa (eye worm) hypothetical protein 0.0083 0.0553 0.1247
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0049 0.0111
Onchocerca volvulus 0.001 0.0028 0.0028
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0093 0.0209
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0254 0.1232
Toxoplasma gondii thioredoxin reductase 0.0037 0.0222 0.3168
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0014 0.0014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0559 0.1806
Leishmania major oxidoreductase-like protein 0.0008 0.0014 0.007
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0023 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.005 0.024
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.007
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0097 0.2143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.005 0.024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0006 0.000000000043019
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.07 0.07
Brugia malayi Thioredoxin reductase 0.0037 0.0222 0.0499
Loa Loa (eye worm) dehydrogenase 0.0008 0.0014 0.0033
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0014 0.0014
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Schistosoma mansoni hypothetical protein 0.0205 0.1431 0.1431
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0407 0.1343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.005 0.024
Brugia malayi major facilitator superfamily protein 0.001 0.0028 0.0064
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0126 0.2077
Onchocerca volvulus 0.001 0.0028 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0356 0.0342
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Echinococcus granulosus dna polymerase eta 0.0019 0.0093 0.0078
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.005 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0247
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0095 0.0081
Echinococcus multilocularis synaptic vesicle 2 protein 0.001 0.0028 0.0014
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0247
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0014 0.0014
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0028 0.0138
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0626 0.2028
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0008 0.0014 0.0048
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.007
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.005 0.024
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Onchocerca volvulus 0.001 0.0028 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0139 0.0673
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0407 0.0407
Toxoplasma gondii sugar transporter ST3 0.001 0.0028 0.0407
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0108
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.005 0.1097
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0874 0.6246 1
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.001 0.0028 0.0028
Trypanosoma brucei transcription factor BTF3, putative 0.0069 0.0452 0.2193
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0093 0.0209
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0095 0.0215
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.005 0.0069
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Brugia malayi Cytochrome P450 family protein 0.0013 0.0049 0.0111
Trypanosoma brucei sugar transporter, putative 0.001 0.0028 0.0138
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Echinococcus granulosus solute carrier family 22 0.001 0.0028 0.0014
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.007
Echinococcus multilocularis pyruvate kinase 0.0032 0.0191 0.0176
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0126 0.2781
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0093 0.045
Echinococcus granulosus pyruvate kinase 0.0017 0.0078 0.0063
Schistosoma mansoni DNA helicase recq5 0.0009 0.0023 0.0023
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0062 0.0139
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0095 0.0081
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0407 0.0393
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0254 0.1232
Echinococcus granulosus intermediate filament protein 0.0027 0.0151 0.0137
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0093 0.0306
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.007
Trypanosoma brucei glucose transporter, putative 0.001 0.0028 0.0138
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0116 0.0176
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0116 0.0793 0.3848
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.0215
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Brugia malayi Pre-SET motif family protein 0.0623 0.444 1
Onchocerca volvulus 0.001 0.0028 0.0028
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0175 0.892
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0008 0.0014 0.0321
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0039 0.0025
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0191 0.3149
Echinococcus multilocularis transcription factor btf3 0.0069 0.0452 0.0438
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.007
Onchocerca volvulus 0.001 0.0028 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0014 0.007
Plasmodium vivax hexose transporter 0.001 0.0028 0.047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0605 0.0605
Echinococcus granulosus pyruvate kinase 0.0032 0.0191 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0028 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2061 1
Giardia lamblia Reductase, putative 0.0008 0.0014 0.0023
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0151 0.0341
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0175 0.3879
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0014 0.007
Entamoeba histolytica hypothetical protein 0.0069 0.0452 0.0702
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0048 0.0033
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0028 0.0014
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0043 0.0206
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0762 0.3695
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Loa Loa (eye worm) pyruvate kinase 0.0007 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.07 0.1111
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0008 0.0014 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0407 0.1343
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Echinococcus multilocularis solute carrier family 22 0.001 0.0028 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0271
Echinococcus multilocularis lamin dm0 0.0027 0.0151 0.0137
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0008 0.0014 0.007
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0191 0.0584
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0093 0.0078
Schistosoma mansoni DNA helicase recq1 0.0009 0.0023 0.0023
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.0762 0.2478
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0028 0.0064
Onchocerca volvulus 0.0027 0.0151 0.0271
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.007
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.005 0.0708
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0452 0.1018
Trypanosoma brucei glucose transporter, putative 0.001 0.0028 0.0138
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0.0014 0.0207
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0407 0.5818
Echinococcus granulosus lamin 0.0027 0.0151 0.0137
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0762 0.1715
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0116 0.0793 0.2582
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0452 0.0714
Brugia malayi Sugar transporter family protein 0.001 0.0028 0.0064
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0023 0.0009
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0014 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0035 0.002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0051 0.0037
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0014 0.0033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.005 0.024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0023 0.0334
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0023 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.005 0.024
Trypanosoma cruzi glucose transporter, putative 0.001 0.0028 0.0138
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0126 0.5399
Mycobacterium ulcerans dehydrogenase 0.0008 0.0014 0.0048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0254 0.1232
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0191 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0093 0.0209
Treponema pallidum fructose-bisphosphate aldolase 0.0874 0.6246 1
Echinococcus granulosus cpg binding protein 0.0031 0.0183 0.0168
Onchocerca volvulus 0.0029 0.0171 0.0309
Echinococcus multilocularis pyruvate kinase 0.0025 0.0142 0.0127
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0028 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0762 0.121
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.005 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0025 0.0123
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0114 0.0781 0.176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Schistosoma mansoni microtubule-associated protein tau 0.1395 1 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0553 0.0553
Brugia malayi pyruvate kinase, muscle isozyme 0.0007 0.0007 0.0016
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.001 0.0028 0.0046
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0605 0.0605
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0093 0.0259
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.001 0.0028 0.0014
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0126 0.0369
Mycobacterium ulcerans oxidoreductase 0.0008 0.0014 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0093 0.045
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0093 0.045
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0605 0.8649
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0623 0.444 1
Schistosoma mansoni lamin 0.0027 0.0151 0.0151
Brugia malayi Sugar transporter family protein 0.001 0.0028 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0874 0.6246 1
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0048 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0014 0.0023
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0171 0.0384
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.0781 0.0768
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0006 0.000000000043019
Echinococcus multilocularis pyruvate kinase 0.0017 0.0078 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0006 0.000000000043019
Schistosoma mansoni sugar transporter 0.001 0.0028 0.0028
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.005 0.0079
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma brucei unspecified product 0.0019 0.0093 0.045
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0014 0.0207
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0014 0.007
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0093 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0139 0.3069
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0139 0.2293
Brugia malayi hypothetical protein 0.0016 0.0075 0.0168
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Leishmania major dehydrogenase-like protein 0.0008 0.0014 0.007
Schistosoma mansoni glucose transport protein 0.001 0.0028 0.0028
Mycobacterium ulcerans sugar transporter 0.001 0.0028 0.0094
Plasmodium falciparum steroid dehydrogenase, putative 0.0008 0.0014 0.0321
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.001 0.0028 0.0094
Toxoplasma gondii transporter, major facilitator family protein 0.001 0.0028 0.0407
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0014 0.0033
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0014 0.0033
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0191 0.0295
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0028 0.0138
Leishmania major glucose transporter, lmgt1 0.001 0.0028 0.0138
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0191 0.0349
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0126 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0014 0.007
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0062 0.0139
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Trichomonas vaginalis glucose transporter, putative 0.001 0.0028 0.0035
Leishmania major short chain dehydrogenase, putative 0.0008 0.0014 0.007
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0083 0.0083
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Echinococcus granulosus solute carrier family 22 0.001 0.0028 0.0014
Onchocerca volvulus 0.001 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0762 0.1199
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0051 0.0037
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.07 0.1111
Onchocerca volvulus 0.009 0.0605 0.1171
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.07 0.3394
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0559 0.1806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0006 0.000000000043019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0429
Brugia malayi hypothetical protein 0.001 0.0028 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Leishmania major myo-inositol/proton symporter (MIT) 0.001 0.0028 0.0138
Echinococcus multilocularis geminin 0.0205 0.1431 0.1419
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0049 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0116 0.0793 0.1786
Onchocerca volvulus 0.001 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.001 0.0028 0.0028
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0427 0.303 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0139 0.0673
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Plasmodium vivax SET domain protein, putative 0.009 0.0605 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0175 0.3879
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0078 0.1108
Brugia malayi beta-NAC-like protein 0.0069 0.0452 0.1018
Giardia lamblia Pyruvate kinase 0.0017 0.0078 0.0124
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0191 0.0925
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0014 0.0048
Brugia malayi hypothetical protein 0.0008 0.0014 0.0033
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0762 0.0762
Loa Loa (eye worm) sugar transporter 0.001 0.0028 0.0064
Plasmodium vivax glutathione reductase, putative 0.0037 0.0222 0.3664
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0023 0.0053
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.005 0.005
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0207
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.005 0.0035
Echinococcus granulosus synaptic vesicle 2 protein 0.001 0.0028 0.0014
Echinococcus multilocularis microtubule associated protein 2 0.1395 1 1
Onchocerca volvulus 0.001 0.0028 0.0028
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.0781 0.0768
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0093 0.0125
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0014 0.007
Echinococcus multilocularis musashi 0.0027 0.0151 0.0137
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0874 0.6246 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0191 0.0925
Plasmodium vivax steroid dehydrogenase, putative 0.0008 0.0014 0.024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.001 0.0028 0.0094
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2061 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.001 0.0028 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Onchocerca volvulus 0.001 0.0028 0.0028
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0191 0.0925
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0035 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Loa Loa (eye worm) POT family protein 0.0081 0.0543 0.1222
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0222 0.0499
Brugia malayi hypothetical protein 0.0025 0.0139 0.0312
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0014 0.0048
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0175 0.2506
Schistosoma mansoni carbonyl reductase 0.0008 0.0014 0.0014
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0762 0.3695
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0116 0.0793 0.0793
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0762 0.1199
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0014 0.0033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0175 0.0271
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0191 0.0429
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0008 0.0014 0.0321
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0116 0.0102
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0407 0.0407
Echinococcus multilocularis dna polymerase eta 0.0019 0.0093 0.0078
Trypanosoma cruzi sugar transporter, putative 0.001 0.0028 0.0138
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0356 0.0802
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0175 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0605 0.0605
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0254 0.1232
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0175 0.2898
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0126 0.1796
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0191 0.0584
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.0793 0.2617
Leishmania major glucose transporter/membrane transporter D2, putative 0.001 0.0028 0.0138
Entamoeba histolytica hypothetical protein 0.0023 0.0126 0.0178
Plasmodium falciparum thioredoxin reductase 0.0037 0.0222 0.4904
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Mycobacterium tuberculosis Probable reductase 0.0083 0.0559 0.1806
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Schistosoma mansoni sugar transporter 0.001 0.0028 0.0028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0093 0.0093
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0605 0.0591
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.0793 0.078
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0452 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0078 0.0063
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0023 0.0334
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.07 0.0686
Trichomonas vaginalis set domain proteins, putative 0.0709 0.5058 0.8096
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0874 0.6246 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.07 0.3394
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0043 0.0206
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0356 0.0802
Brugia malayi MAP kinase sur-1 0.0103 0.07 0.1576
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.001 0.0028 0.0629
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.007
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.07 0.3394
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.0793 0.078
Leishmania major short chain dehydrogenase-like protein 0.0008 0.0014 0.007
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0559 0.1806
Echinococcus granulosus GPCR family 2 0.0019 0.0095 0.0081
Leishmania major trypanothione reductase 0.0037 0.0222 0.1076
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0093 0.0093
Onchocerca volvulus 0.0083 0.0553 0.1069
Brugia malayi CXXC zinc finger family protein 0.0029 0.0171 0.0384
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0116 0.0261
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0008 0.0014 0.0048
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.07 0.3394
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0432 0.0432
Toxoplasma gondii hypothetical protein 0.0047 0.0297 0.4252
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.005 0.024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0874 0.6246 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0093 0.045
Schistosoma mansoni lamin 0.0027 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0095 0.0215
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0762 0.121
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.0762 0.2514
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0116 0.0176
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.07 0.112
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0427 0.303 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0028 0.0035
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0605 0.0591
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0095 0.0081
Leishmania major pteridine reductase 1 0.0008 0.0014 0.007
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0553 0.054
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0093 0.0078
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0356 0.0342
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.07 0.3394
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0014 0.0048
Brugia malayi Pre-SET motif family protein 0.009 0.0605 0.1363
Onchocerca volvulus 0.001 0.0028 0.0028
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0029 0.0064
Onchocerca volvulus 0.0027 0.0151 0.0271
Plasmodium falciparum glutathione reductase 0.0037 0.0222 0.4904
Schistosoma mansoni glucose transport protein 0.001 0.0028 0.0028
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0014 0.007
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0407 0.1975
Loa Loa (eye worm) hypothetical protein 0.0023 0.012 0.0271
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0225 0.0211
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0175 0.2898
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0023 0.0009
Echinococcus multilocularis cpg binding protein 0.0031 0.0183 0.0168
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0207
Schistosoma mansoni carbonyl reductase 0.0008 0.0014 0.0014
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Loa Loa (eye worm) sugar transporter 0.001 0.0028 0.0064
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0006 0.000000000043019
Schistosoma mansoni transcription factor btf3 0.0069 0.0452 0.0452
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0025 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0874 0.6246 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.005 0.0164
Leishmania major hypothetical protein, conserved 0.0009 0.0025 0.0123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Schistosoma mansoni cpg binding protein 0.0031 0.0183 0.0183
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0008 0.0014 0.0048
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0078 0.1715
Onchocerca volvulus 0.001 0.0028 0.0028
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.005 0.0819
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.07 0.1111
Brugia malayi Cytochrome P450 family protein 0.0013 0.0049 0.0111
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0874 0.6246 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Trichomonas vaginalis sugar transport protein, putative 0.001 0.0028 0.0035
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0028 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0014 0.007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0407 0.1302
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Brugia malayi major facilitator superfamily protein 0.001 0.0028 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.007
Leishmania major DNA polymerase eta, putative 0.0019 0.0093 0.045
Loa Loa (eye worm) hypothetical protein 0.0013 0.0051 0.0116
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0028 0.0064
Brugia malayi hypothetical protein 0.001 0.0028 0.0064
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0064 0.091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0356 0.0342
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0006 0.000000000043019
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0047 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0356 0.0356
Trypanosoma cruzi hexose transporter, putative 0.001 0.0028 0.0138
Echinococcus multilocularis solute carrier family 22 0.001 0.0028 0.0014
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.0762 0.3695
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0762 0.0762
Echinococcus granulosus transcription factor btf3 0.0069 0.0452 0.0438
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0006 0.000000000043019
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.005 0.024
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0023 0.0009
Mycobacterium ulcerans hypothetical protein 0.0154 0.1066 0.3518
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.005 0.0112
Mycobacterium ulcerans oxidoreductase 0.0008 0.0014 0.0048
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0.0014 0.0207
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0028 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.005 0.024
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.0762 0.1149
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0553 0.1247
Schistosoma mansoni hypothetical protein 0.0019 0.0095 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0095 0.0081
Brugia malayi POT family protein 0.0081 0.0543 0.1222
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.007
Giardia lamblia Fructose-bisphosphate aldolase 0.0874 0.6246 1
Echinococcus granulosus pyruvate kinase 0.0032 0.0191 0.0176
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0.0014 0.007
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0043 0.0058
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Toxoplasma gondii sugar transporter ST1 0.001 0.0028 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0874 0.6246 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0093 0.0306
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0093 0.045
Trypanosoma brucei glucose transporter, putative 0.001 0.0028 0.0138
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0033
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0028 0.0138
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.005 0.024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0093 0.045
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0626 0.2028
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0126 0.1796
Echinococcus granulosus pyruvate kinase 0.0017 0.0078 0.0063
Trypanosoma cruzi hexose transporter, putative 0.001 0.0028 0.0138
Brugia malayi 6-phosphofructokinase 0.0112 0.0762 0.1715
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0093 0.0209
Mycobacterium ulcerans short-chain type oxidoreductase 0.0008 0.0014 0.0048
Onchocerca volvulus 0.001 0.0028 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0319 0.1546
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.2061 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0043 0.0206
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.0762 0.0748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0605 0.0605
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0139 0.3069
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0427 0.303 1
Giardia lamblia Sugar-proton symporter 0.001 0.0028 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0126 0.061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0312
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0762 0.1715
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.007
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.007
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.2061 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0028 0.0035
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0028 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0407 0.1343
Leishmania major glucose transporter, lmgt3 0.001 0.0028 0.0138
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0033
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0049 0.0162
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.0033
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0008 0.0014 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0012 0.0012
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0025 0.0057
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0048
Onchocerca volvulus 0.0709 0.5058 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0191 0.0429
Onchocerca volvulus 0.001 0.0028 0.0028
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Trypanosoma brucei glucose transporter, putative 0.001 0.0028 0.0138
Echinococcus multilocularis pyruvate kinase 0.0032 0.0191 0.0176
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0452 0.747
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0048
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.007
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Echinococcus multilocularis solute carrier family 22 0.001 0.0028 0.0014
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0191 0.2724
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0093 0.045
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0191 0.0629
Echinococcus multilocularis pyruvate kinase 0.0017 0.0078 0.0063
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0392 0.0882
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0035 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.005 0.024
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.07 0.3394
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0114 0.0781 0.176
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0014 0.0033
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0014 0.0013
Echinococcus multilocularis pyruvate kinase 0.0017 0.0078 0.0063
Echinococcus granulosus lamin dm0 0.0027 0.0151 0.0137
Echinococcus granulosus solute carrier family 22 0.001 0.0028 0.0014
Schistosoma mansoni hypothetical protein 0.0205 0.1431 0.1431
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.007
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Toxoplasma gondii sugar transporter ST2 0.001 0.0028 0.0407
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0049 0.0239
Trichomonas vaginalis sugar transporter, putative 0.001 0.0028 0.0035
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0.0014 0.0207

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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