Detailed information for compound 1671280

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.507 | Formula: C24H30N2O3
  • H donors: 0 H acceptors: 1 LogP: 4.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1cc(OC)c(c(c1)OC)c1ccc2c(n1)c(C)ccc2N(CC)CC
  • InChi: 1S/C24H30N2O3/c1-7-26(8-2)20-12-9-16(3)24-18(20)10-11-19(25-24)23-21(28-5)13-17(15-27-4)14-22(23)29-6/h9-14H,7-8,15H2,1-6H3
  • InChiKey: JFHJTHQBLSHFIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0027 0.0012 0.004
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0036 0.0021 0.0021
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0105 0.0094 0.0304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0394 0.0397 0.0413
Entamoeba histolytica heat shock protein 90, putative 0.0165 0.0156 1
Loa Loa (eye worm) GABA receptor subunit 0.0019 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Echinococcus multilocularis dro:myosuppressin receptor 0.0394 0.0397 0.0413
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0088 0.0076 0.0075
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0026 0.0579
Schistosoma mansoni nAChR subunit 0.0036 0.0021 0.0067
Leishmania major eukaryotic translation initiation factor-like 0.0044 0.0029 0.0095
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0119 0.0108 0.035
Echinococcus multilocularis histone deacetylase 0.0035 0.0021 0.0021
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0165 0.0156 0.3715
Echinococcus multilocularis histone deacetylase 6 0.0035 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Leishmania major cathepsin L-like protease 0.0052 0.0039 0.0125
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0394 0.0397 0.0413
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Schistosoma mansoni heat shock protein 0.0165 0.0156 0.0505
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.1035 0.1069 0.3462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0065
Onchocerca volvulus 0.0052 0.0039 0.0972
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0044 0.0029 0.0094
Onchocerca volvulus 0.0394 0.0397 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0021 0.0067
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0027 0.0012 0.0039
Echinococcus multilocularis acetylcholinesterase 0.0059 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0084 0.0072 0.0234
Trypanosoma brucei heat shock protein 90, putative 0.0165 0.0156 0.0506
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0105 0.0094 0.0094
Brugia malayi RE15519p 0.0394 0.0397 0.1285
Schistosoma mansoni hypothetical protein 0.0048 0.0034 0.0107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0083 0.5321
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0117 0.0106 0.0344
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Echinococcus granulosus intermediate filament protein 0.0023 0.0008 0.0008
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0165 0.0156 0.0162
Onchocerca volvulus 0.0062 0.0049 0.123
Brugia malayi hypothetical protein 0.0545 0.0555 0.1797
Schistosoma mansoni biogenic amine (5HT) receptor 0.0586 0.0598 0.1936
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus multilocularis allatostatin A receptor 0.0394 0.0397 0.0413
Schistosoma mansoni alpha-1 adrenergic receptor 0.0394 0.0397 0.1285
Echinococcus multilocularis histone deacetylase 6 0.0035 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0062 0.0049 0.3067
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0044 0.0029 0.0095
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Echinococcus granulosus alpha 1A adrenergic receptor 0.0394 0.0397 0.0397
Echinococcus granulosus serotonin receptor 0.0394 0.0397 0.0397
Loa Loa (eye worm) acetylcholine receptor protein 0.0017 0.0001 0.0003
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0039 0.0746
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0038 0.0023 0.0023
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0165 0.0156 0.0506
Echinococcus multilocularis serotonin transporter 0.0366 0.0368 0.0382
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0057 0.0043 0.0138
Schistosoma mansoni nAChR subunit 0.0017 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0394 0.0397 1
Echinococcus multilocularis neuropeptide receptor 0.0394 0.0397 0.0413
Trypanosoma cruzi protein kinase A regulatory subunit 0.0027 0.0012 0.004
Onchocerca volvulus 0.0394 0.0397 1
Plasmodium vivax histone deacetylase 2, putative 0.0035 0.0021 0.0547
Echinococcus granulosus dro:myosuppressin receptor 0.0394 0.0397 0.0397
Schistosoma mansoni neuropeptide receptor 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0039 0.2317
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0055 0.0041 0.0042
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0026 0.0026
Brugia malayi Endoplasmin precursor 0.0165 0.0156 0.0505
Brugia malayi Protein kinase domain containing protein 0.0187 0.018 0.0581
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0165 0.0156 0.9876
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus multilocularis heat shock protein 0.0165 0.0156 0.0162
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.0035 0.0035
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0036 0.0021 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0098 0.0086 0.0277
Schistosoma mansoni hypothetical protein 0.0098 0.0086 0.0277
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0158
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0366 0.0368 0.119
Loa Loa (eye worm) carboxylesterase 0.0059 0.0045 0.0146
Loa Loa (eye worm) solute carrier family 6 member 4 0.0366 0.0368 0.1191
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0013 0.0041
Plasmodium vivax glutathione reductase, putative 0.0037 0.0023 0.0607
Toxoplasma gondii histone deacetylase HDAC1 0.0035 0.0021 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Loa Loa (eye worm) hypothetical protein 0.0042 0.0028 0.009
Schistosoma mansoni hypothetical protein 0.0026 0.0011 0.0033
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0027 0.0012 0.0039
Trypanosoma brucei heat shock protein, putative 0.0165 0.0156 0.0506
Onchocerca volvulus 0.0394 0.0397 1
Echinococcus granulosus g protein coupled receptor 0.0394 0.0397 0.0397
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Brugia malayi N-terminal motif family protein 0.0233 0.0228 0.0739
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0004 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0023 0.0075
Trypanosoma cruzi heat shock protein 85, putative 0.0165 0.0156 0.0506
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0105 0.0094 0.0094
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0165 0.0156 0.6191
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0278 0.0275 0.089
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0039 0.0024 0.0024
Brugia malayi Cation transporter family protein 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0055 0.0041 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0076
Loa Loa (eye worm) sodium/hydrogen exchanger 0.0038 0.0023 0.0076
Leishmania major protein kinase A regulatory subunit, putative 0.0027 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.006 0.0047 0.0152
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0013 0.0043
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0394 0.0397 0.1285
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0039 0.0024 0.0024
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0012 0.0012
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Plasmodium falciparum transporter, putative 0.0105 0.0094 0.2337
Echinococcus multilocularis sodium and chloride dependent glycine 0.0321 0.032 0.0333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Loa Loa (eye worm) melatonin receptor type 1A 0.0394 0.0397 0.1286
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0027 0.0012 0.0039
Echinococcus granulosus protein tyrosine kinase 0.0185 0.0178 0.0177
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0027 0.0012 0.0012
Echinococcus granulosus glycine receptor subunit beta 0.0036 0.0021 0.0021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0062 0.0049 0.0158
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0165 0.0156 0.1171
Schistosoma mansoni hypothetical protein 0.0048 0.0034 0.0107
Schistosoma mansoni biogenic amine receptor 0.0394 0.0397 0.1285
Trypanosoma cruzi Heat shock protein 83, putative 0.0165 0.0156 0.0506
Echinococcus multilocularis cathepsin b 0.0084 0.0072 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0194 0.0187 0.0604
Echinococcus granulosus sodium and chloride dependent glycine 0.0321 0.032 0.032
Loa Loa (eye worm) TAR-binding protein 0.0117 0.0106 0.0344
Schistosoma mansoni hypothetical protein 0.0361 0.0362 0.1173
Leishmania major cathepsin L-like protease 0.0052 0.0039 0.0125
Plasmodium vivax vivapain-3 0.0028 0.0013 0.0334
Brugia malayi hypothetical protein 0.0361 0.0362 0.1173
Schistosoma mansoni neurotransmitter gated ion channel 0.0019 0.0004 0.0011
Echinococcus granulosus sodium:hydrogen exchanger 0.0038 0.0023 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0394 0.0397 0.1285
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0038 0.0023 0.0023
Entamoeba histolytica DNA topoisomerase II, putative 0.0165 0.0156 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0062 0.0049 0.0157
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0021 0.0067
Echinococcus multilocularis lipoxygenase domain containing protein 0.0361 0.0362 0.0377
Echinococcus multilocularis musashi 0.0023 0.0008 0.0008
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0394 0.0397 0.1285
Echinococcus multilocularis serotonin receptor 0.0586 0.0598 0.0623
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0038 0.0023 0.0023
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0039 0.0024 0.0024
Echinococcus granulosus cGMP dependent protein kinase 1 0.0028 0.0013 0.0013
Brugia malayi hypothetical protein 0.0017 0.0001 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0321 0.032 0.1037
Echinococcus granulosus cathepsin l1 0.0052 0.0039 0.0038
Echinococcus granulosus sodium and chloride dependent glycine 0.0321 0.032 0.032
Loa Loa (eye worm) serotonin transporter b 0.0366 0.0368 0.1191
Plasmodium falciparum amino acid transporter, putative 0.0105 0.0094 0.2337
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0027 0.0012 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0361 0.0362 0.0377
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Trypanosoma brucei protein kinase A regulatory subunit 0.0027 0.0012 0.004
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.0013 0.0042
Entamoeba histolytica hypothetical protein 0.0098 0.0086 0.5406
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0004 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0394 0.0397 0.0413
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0394 0.0397 0.0413
Loa Loa (eye worm) hypothetical protein 0.0174 0.0166 0.0539
Brugia malayi Matrixin family protein 0.0084 0.0072 0.023
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0045 0.0145
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0105 0.0094 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0035 0.2214
Brugia malayi MH2 domain containing protein 0.0173 0.0166 0.0535
Loa Loa (eye worm) acetyltransferase 0.0131 0.0121 0.0391
Brugia malayi Dopamine receptor 0.0394 0.0397 0.1285
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0314 0.0313 0.0312
Echinococcus granulosus heat shock protein 0.0165 0.0156 0.0156
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0165 0.0156 0.3715
Trypanosoma brucei heat shock protein, putative 0.0165 0.0156 0.0506
Brugia malayi CHE-14 protein 0.0049 0.0035 0.0113
Schistosoma mansoni hypothetical protein 0.0394 0.0397 0.1285
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0012 0.0039
Schistosoma mansoni neuropeptide F-like receptor 0.0394 0.0397 0.1285
Brugia malayi Cathepsin L-like precursor 0.0036 0.0021 0.0067
Echinococcus multilocularis glycine receptor subunit beta 0.0036 0.0021 0.0021
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0027 0.0012 0.0012
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Echinococcus multilocularis non capsid protein NS 1 0.0018 0.0003 0.0002
Onchocerca volvulus Putative nachr subunit 0.0036 0.0021 0.0535
Echinococcus multilocularis heat shock protein 90 0.0165 0.0156 0.0162
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0027 0.0012 0.0039
Brugia malayi heat shock protein 90 0.0165 0.0156 0.0505
Onchocerca volvulus 0.0394 0.0397 1
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0027 0.0012 0.0316
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0028 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0039 0.0125
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus granulosus lipoxygenase domain containing protein 0.0361 0.0362 0.0362
Loa Loa (eye worm) LGC-31 protein 0.0036 0.0021 0.0069
Loa Loa (eye worm) hypothetical protein 0.0091 0.0079 0.0255
Brugia malayi ORL1-like opioid receptor 0.0394 0.0397 0.1285
Schistosoma mansoni opsin-like receptor 0.0394 0.0397 0.1285
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0019 0.0059
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0016 0.0001 0.0003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0366 0.0368 0.119
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Echinococcus multilocularis expressed conserved protein 0.0028 0.0013 0.0012
Brugia malayi Matrixin family protein 0.0035 0.002 0.0064
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0394 0.0397 0.1285
Schistosoma mansoni DNA topoisomerase II 0.0165 0.0156 0.0505
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0039 0.0024 0.0079
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0394 0.0397 0.1285
Onchocerca volvulus 0.0036 0.0021 0.0535
Trypanosoma brucei developmentally regulated phosphoprotein 0.296 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0076 0.0246
Brugia malayi Cathepsin L-like precursor 0.0052 0.0039 0.0124
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0165 0.0156 0.9876
Echinococcus multilocularis Polycystic kidney disease protein 0.0361 0.0362 0.0377
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0065
Echinococcus multilocularis sodium and chloride dependent glycine 0.0321 0.032 0.0333
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0023 0.0607
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0158
Brugia malayi RNA binding protein 0.0117 0.0106 0.0343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0011 0.001
Echinococcus granulosus tachykinin peptides receptor 99D 0.0573 0.0585 0.0584
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Brugia malayi Dopamine receptor protein 1 0.0394 0.0397 0.1285
Echinococcus granulosus rhodopsin orphan GPCR 0.0394 0.0397 0.0397
Plasmodium falciparum cGMP-dependent protein kinase 0.0028 0.0013 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0117 0.0106 0.0343
Trypanosoma cruzi cAMP binding protein, putative 0.0027 0.0012 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0394 0.0397 0.0413
Onchocerca volvulus 0.0052 0.0039 0.0972
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1698 0.1764 0.1839
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0165 0.0156 0.1171
Echinococcus granulosus poly adp ribose polymerase 2 0.0065 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0038 0.0023 0.0588
Loa Loa (eye worm) hypothetical protein 0.0545 0.0555 0.1798
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0013 0.0043
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0027 0.0012 0.0012
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0013 0.0654
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0105 0.0094 0.0304
Schistosoma mansoni adenoreceptor 0.0394 0.0397 0.1285
Onchocerca volvulus 0.0062 0.0049 0.123
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0013 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Schistosoma mansoni hypothetical protein 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Schistosoma mansoni neuropeptide receptor 0.0394 0.0397 0.1285
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0148 0.0139 0.3813
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Leishmania major hypothetical protein, conserved 0.0057 0.0044 0.0142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0394 0.0397 0.0413
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0118 0.0108 0.0349
Mycobacterium tuberculosis Probable oxidoreductase 0.0249 0.0245 0.6
Loa Loa (eye worm) matrixin family protein 0.0077 0.0064 0.0208
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0023 0.0075
Brugia malayi intermediate filament protein 0.0023 0.0008 0.0026
Echinococcus multilocularis nAChR subunit 0.0019 0.0004 0.0003
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0001 0.0002
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0065 0.0052 0.0053
Onchocerca volvulus 0.0361 0.0362 0.9131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Chlamydia trachomatis UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 0.1033 0.1067 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0165 0.0156 0.1171
Chlamydia trachomatis DNA gyrase subunit B 0.0165 0.0156 0.1364
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0084 0.0072 0.0234
Loa Loa (eye worm) neuropeptide F receptor 0.0394 0.0397 0.1286
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0105 0.0094 0.0776
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0027 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0044 0.1186
Schistosoma mansoni rab6-interacting 0.0361 0.0362 0.1173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus granulosus histone acetyltransferase KAT2B 0.0038 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Toxoplasma gondii cathepsin CPC1 0.0148 0.0139 0.1029
Echinococcus granulosus RUN 0.0361 0.0362 0.0362
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0035 0.0035
Onchocerca volvulus Neuropeptide F receptor homolog 0.0394 0.0397 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Echinococcus granulosus rhodopsin orphan GPCR 0.0394 0.0397 0.0397
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.0013 0.0042
Schistosoma mansoni amine GPCR 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0004
Trypanosoma brucei Heat shock protein 83, putative 0.0165 0.0156 0.0506
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0039 0.0125
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0044 0.0029 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0012 0.004
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0131 0.0121 0.039
Echinococcus granulosus cathepsin l1 0.0036 0.0021 0.0021
Onchocerca volvulus 0.0019 0.0004 0.0099
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Brugia malayi hypothetical protein 0.0731 0.0751 0.243
Entamoeba histolytica acetyltransferase, GNAT family 0.0035 0.0021 0.1148
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0027 0.0012 0.0765
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0098 0.0086 0.0086
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0105 0.0094 0.0666
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0047 0.0033 0.0106
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0036 0.0021 0.0069
Echinococcus granulosus poly (ADP ribose) polymerase 0.0018 0.0003 0.0003
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0039 0.0024 0.0078
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Brugia malayi Serotonin receptor 0.0394 0.0397 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0039 0.0024 0.0024
Mycobacterium tuberculosis Conserved protein 0.0165 0.0156 0.3715
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0165 0.0156 0.0156
Schistosoma mansoni sodium/hydrogen exchanger 0.0038 0.0023 0.0074
Echinococcus granulosus glycine receptor subunit alpha 1 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0158
Loa Loa (eye worm) G-protein coupled receptor 0.0394 0.0397 0.1286
Schistosoma mansoni histamine h1 receptor 0.0394 0.0397 0.1285
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0394 0.0397 0.1286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Echinococcus granulosus histone deacetylase 6 0.0035 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0586 0.0598 0.1937
Echinococcus multilocularis neuropeptide s receptor 0.0394 0.0397 0.0413
Onchocerca volvulus 0.0036 0.0021 0.0535
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0027 0.0012 0.004
Schistosoma mansoni hypothetical protein 0.0394 0.0397 0.1285
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0044 0.0029 0.0138
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0019 0.0004 0.0011
Loa Loa (eye worm) TK/FAK protein kinase 0.0187 0.018 0.0582
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0027 0.0012 0.0039
Echinococcus multilocularis sodium:hydrogen exchanger 0.0038 0.0023 0.0023
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0165 0.0156 1
Toxoplasma gondii cathepsin B 0.0034 0.0019 0.0056
Onchocerca volvulus 0.0027 0.0012 0.0315
Onchocerca volvulus 0.0017 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Plasmodium falciparum histone deacetylase, putative 0.0035 0.0021 0.0239
Mycobacterium tuberculosis Conserved protein 0.0062 0.0049 0.0939
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0165 0.0156 0.1364
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0165 0.0156 0.3715
Schistosoma mansoni tar DNA-binding protein 0.0117 0.0106 0.0343
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0105 0.0094 0.0094
Brugia malayi beta-lactamase 0.0062 0.0049 0.0157
Echinococcus multilocularis sex peptide receptor 0.0394 0.0397 0.0413
Echinococcus multilocularis protein tyrosine kinase 0.0185 0.0178 0.0184
Loa Loa (eye worm) cathepsin B 0.0034 0.0019 0.0063
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0165 0.0156 0.3715
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0394 0.0397 0.0397
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Loa Loa (eye worm) hypothetical protein 0.019 0.0183 0.0592
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0026 0.0084
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0537 0.0547 0.1772
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0017 0.0001 0.0002
Onchocerca volvulus 0.0017 0.0001 0.0026
Echinococcus multilocularis neuropeptide receptor 0.0394 0.0397 0.0413
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Loa Loa (eye worm) hypothetical protein 0.0059 0.0045 0.0146
Schistosoma mansoni patched 1 0.0049 0.0035 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0394 0.0397 0.0397
Echinococcus multilocularis fmrfamide receptor 0.0394 0.0397 0.0413
Mycobacterium ulcerans esterase/lipase LipP 0.0062 0.0049 0.1564
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0028 0.0013 0.0042
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Trichomonas vaginalis receptor histidine kinase, putative 0.0165 0.0156 0.9876
Onchocerca volvulus 0.0149 0.014 0.353
Loa Loa (eye worm) hypothetical protein 0.0586 0.0598 0.1937
Onchocerca volvulus 0.0052 0.0039 0.0972
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Brugia malayi larval opioid receptor 0.0394 0.0397 0.1285
Echinococcus granulosus mitogen activated protein kinase 14 0.0118 0.0108 0.0107
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0036 0.0021 0.0067
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0055 0.0041 0.0041
Mycobacterium tuberculosis Probable lipase LipD 0.0062 0.0049 0.0939
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0049 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0013 0.0041
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0039 0.0039
Echinococcus multilocularis transfer RNA-Trp 0.0038 0.0023 0.0023
Trypanosoma brucei heat shock protein, putative 0.0165 0.0156 0.0506
Treponema pallidum sodium- and chloride- dependent transporter 0.0366 0.0368 1
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0094 0.2579
Loa Loa (eye worm) acetylcholinesterase 1 0.0059 0.0045 0.0146
Schistosoma mansoni hypothetical protein 0.0088 0.0076 0.0244
Giardia lamblia Encystation-specific protease 0.0063 0.005 0.2612
Brugia malayi glutathione reductase 0.0037 0.0023 0.0073
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Mycobacterium ulcerans putative regultory protein 0.0165 0.0156 0.6191
Brugia malayi G-protein coupled receptor 0.0394 0.0397 0.1285
Echinococcus granulosus Polycystic kidney disease protein 0.0361 0.0362 0.0362
Loa Loa (eye worm) transcription factor SMAD2 0.0173 0.0166 0.0536
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0158
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0165 0.0156 0.6191
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0394 0.0397 0.1285
Schistosoma mansoni hypothetical protein 0.0049 0.0035 0.0113
Onchocerca volvulus 0.0017 0.0001 0.0026
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0165 0.0156 0.6191
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0023 0.0272
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0039 0.0124
Onchocerca volvulus 0.0052 0.0039 0.0972
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Mycobacterium ulcerans two component sensor kinase MprB 0.0165 0.0156 0.6191
Loa Loa (eye worm) hypothetical protein 0.0366 0.0368 0.1191
Trichomonas vaginalis heat shock protein, putative 0.0165 0.0156 0.9876
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0062 0.0049 0.0157
Plasmodium falciparum heat shock protein 90 0.0165 0.0156 0.4111
Plasmodium vivax heat shock protein 86, putative 0.0165 0.0156 0.4297
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0096 0.0085 0.533
Brugia malayi Matrixin family protein 0.0035 0.002 0.0064
Plasmodium vivax endoplasmin, putative 0.0165 0.0156 0.4297
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0023 0.0023
Echinococcus granulosus histone deacetylase 7 0.0035 0.0021 0.002
Schistosoma mansoni nAChR subunit 0.0036 0.0021 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0394 0.0397 0.0413
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0001 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0126 0.0116 0.0375
Loa Loa (eye worm) glutamate receptor 0.004 0.0025 0.0082
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0024 0.0008 0.0026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0019 0.0061
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus granulosus lamin dm0 0.0023 0.0008 0.0008
Schistosoma mansoni sodium/chloride dependent transporter 0.0322 0.0321 0.1038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0076
Giardia lamblia Cathepsin B precursor 0.0034 0.0019 0.0479
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0036 0.0021 0.0021
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0025 0.0081
Leishmania major trypanothione reductase 0.0037 0.0023 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0174 0.0166 0.0539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0394 0.0397 0.0413
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0039 0.0038
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0027 0.0012 0.0039
Echinococcus granulosus neuropeptide s receptor 0.0394 0.0397 0.0397
Echinococcus multilocularis neuropeptides capa receptor 0.0394 0.0397 0.0413
Echinococcus granulosus acetylcholinesterase 0.0059 0.0045 0.0045
Echinococcus granulosus neuropeptide FF receptor 2 0.0394 0.0397 0.0397
Brugia malayi Hemopexin family protein 0.0049 0.0035 0.0113
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0027 0.0012 0.0039
Brugia malayi hypothetical protein 0.0361 0.0362 0.1173
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0027 0.0012 0.0316
Entamoeba histolytica hypothetical protein 0.0098 0.0086 0.5406
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus granulosus WGR domain containing protein 0.0037 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0165 0.0156 0.0506
Echinococcus granulosus peptide allatostatin:somatostatin 0.0394 0.0397 0.0397
Brugia malayi Cation transporter family protein 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0026 0.0347
Echinococcus multilocularis mitogen activated protein kinase 14 0.0118 0.0108 0.0111
Loa Loa (eye worm) hypothetical protein 0.015 0.0141 0.0458
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0012 0.0039
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.296 0.3087 0.3087
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0062 0.0049 0.0939
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Schistosoma mansoni acetylcholine receptor subunit beta 0.0017 0.0001 0.0002
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0027 0.0012 0.0012
Brugia malayi GnHR receptor homolog 0.0394 0.0397 0.1285
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0013 0.0655
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0178 0.017 0.0177
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0001 0.0003
Onchocerca volvulus 0.0052 0.0039 0.0972
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0036 0.0021 0.0067
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Brugia malayi TAR-binding protein 0.0117 0.0106 0.0343
Brugia malayi Cathepsin L-like precursor 0.0052 0.0039 0.0124
Onchocerca volvulus 0.0394 0.0397 1
Schistosoma mansoni neuropeptide receptor 0.0394 0.0397 0.1285
Mycobacterium tuberculosis Conserved protein 0.0062 0.0049 0.0939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0013 0.0805
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Onchocerca volvulus 0.0023 0.0008 0.0209
Schistosoma mansoni 60S ribosomal protein L21 0.0027 0.0012 0.0039
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0001 0.0002
Onchocerca volvulus 0.0394 0.0397 1
Schistosoma mansoni ets-related 0.0116 0.0105 0.0338
Onchocerca volvulus Matrilysin homolog 0.0035 0.002 0.0504
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0537 0.0547 0.1771
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0022 0.0068
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus granulosus rhodopsin orphan GPCR 0.0394 0.0397 0.0397
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0035 0.0115
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0065 0.0052 0.0169
Schistosoma mansoni biogenic amine receptor 0.0394 0.0397 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0019 0.1201
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0044 0.0142
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0073 0.1572
Loa Loa (eye worm) AGC/PKG protein kinase 0.0028 0.0013 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0273 0.027 0.0281
Toxoplasma gondii cathepsin CPC2 0.0063 0.005 0.0306
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0394 0.0397 0.1285
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0019 0.0018
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0073 0.1572
Echinococcus multilocularis mitogen activated protein kinase 11 0.0118 0.0108 0.0111
Echinococcus granulosus expressed conserved protein 0.0108 0.0097 0.0096
Entamoeba histolytica hypothetical protein 0.0098 0.0086 0.5406
Mycobacterium ulcerans DNA gyrase subunit B 0.0165 0.0156 0.6191
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0036 0.0021 0.0021
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0165 0.0156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus multilocularis rhodopsin orphan GPCR 0.0394 0.0397 0.0413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus granulosus heat shock protein 90 0.0165 0.0156 0.0156
Echinococcus multilocularis GA binding protein alpha chain 0.0038 0.0024 0.0024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0397 0.04 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Schistosoma mansoni polycystin 1-related 0.0361 0.0362 0.1173
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0394 0.0397 0.0397
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0105 0.0094 0.0097
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Leishmania major cathepsin L-like protease 0.0052 0.0039 0.0125
Schistosoma mansoni nAChR subunit 0.0036 0.0021 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Echinococcus multilocularis G-protein coupled receptor, putative 0.0394 0.0397 0.0413
Echinococcus multilocularis acetylcholinesterase 0.0059 0.0045 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0026 0.0084
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0031 0.01
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus granulosus cysteine protease 0.0028 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Echinococcus granulosus cpg binding protein 0.0028 0.0014 0.0013
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0019 0.0018
Trypanosoma brucei trypanothione reductase 0.0037 0.0023 0.0075
Mycobacterium tuberculosis Probable hydrolase 0.0062 0.0049 0.0939
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0026 0.1617
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Brugia malayi Cation transporter family protein 0.0036 0.0021 0.0067
Brugia malayi excitatory GABA receptor EXP-1A 0.0036 0.0021 0.0067
Mycobacterium tuberculosis Conserved protein 0.0062 0.0049 0.0939
Onchocerca volvulus 0.0027 0.0012 0.0315
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0038 0.0023 0.0588
Leishmania major hypothetical protein, conserved 0.0027 0.0012 0.004
Onchocerca volvulus 0.0394 0.0397 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0039 0.0024 0.0078
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0062 0.0049 0.1564
Echinococcus multilocularis orexin receptor type 2 0.0394 0.0397 0.0413
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0044 0.0029 0.0095
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0039 0.0972
Trichomonas vaginalis endoplasmin, putative 0.0165 0.0156 0.9876
Schistosoma mansoni rab6-interacting 0.0361 0.0362 0.1173
Onchocerca volvulus 0.0394 0.0397 1
Schistosoma mansoni gabp alpha 0.0038 0.0024 0.0075
Schistosoma mansoni hypothetical protein 0.0048 0.0034 0.0107
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0039 0.0124
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0013 0.0043
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0058
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0036 0.0021 0.0069
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0084 0.0072 0.0232
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0039 0.0039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.061 0.0623 0.2018
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0233 0.0228 0.5755
Loa Loa (eye worm) hypothetical protein 0.0057 0.0044 0.0142
Loa Loa (eye worm) NHE-3 0.0038 0.0023 0.0076
Giardia lamblia Heat shock protein HSP 90-alpha 0.0165 0.0156 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0165 0.0156 0.6191
Echinococcus multilocularis cysteine protease 0.0052 0.0039 0.0039
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Brugia malayi hypothetical protein 0.0017 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0088 0.0076 0.0244
Loa Loa (eye worm) hypothetical protein 0.0105 0.0094 0.0305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Leishmania major cathepsin L-like protease 0.0052 0.0039 0.0125
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0073 0.1572
Echinococcus multilocularis g-protein coupled receptor 0.0394 0.0397 0.0413
Loa Loa (eye worm) hypothetical protein 0.0105 0.0094 0.0305
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0024 0.1522
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0026 0.0688
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0126 0.0116 0.0116
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0148 0.0139 0.3813
Echinococcus granulosus neuropeptide Y receptor 0.0394 0.0397 0.0397
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0034 0.0019 0.0063
Trypanosoma cruzi heat shock protein 85, putative 0.0165 0.0156 0.0506
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0394 0.0397 0.1285
Echinococcus granulosus rhodopsin orphan GPCR 0.0394 0.0397 0.0397
Leishmania major DNA topoisomerase ii 0.0165 0.0156 0.0506
Entamoeba histolytica hypothetical protein 0.0019 0.0004 0.0055
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Loa Loa (eye worm) hypothetical protein 0.0361 0.0362 0.1174
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0165 0.0156 0.4051
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.0104 0.6591
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0044 0.0029 0.1835
Brugia malayi P38 map kinase family protein 2 0.0118 0.0108 0.0348
Mycobacterium leprae Probable two-component sensor kinase 0.0165 0.0156 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0036 0.0021 0.0021
Echinococcus granulosus sodium:hydrogen exchanger 0.0038 0.0023 0.0023
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0039 0.0024 0.0079
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0118 0.0108 0.0349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0126 0.0116 0.0375
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Loa Loa (eye worm) fibroinase 0.0052 0.0039 0.0125
Toxoplasma gondii thioredoxin reductase 0.0037 0.0023 0.0086
Brugia malayi AKH receptor 0.0394 0.0397 0.1285
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0027 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0039 0.0972
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0394 0.0397 0.0413
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0394 0.0397 0.0397
Echinococcus granulosus cathepsin b 0.0084 0.0072 0.0072
Onchocerca volvulus 0.0049 0.0035 0.0887
Echinococcus granulosus g protein coupled receptor 0.0394 0.0397 0.0397
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0126 0.0116 0.0375
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0394 0.0397 0.0413
Schistosoma mansoni intermediate filament proteins 0.0023 0.0008 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0062 0.0049 0.3067
Brugia malayi Cathepsin L-like precursor 0.0036 0.0021 0.0067
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0105 0.0094 0.0304
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0158
Echinococcus multilocularis transfer RNA-Gly 0.0038 0.0023 0.0023
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.003 0.0015 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0073 0.1572
Onchocerca volvulus 0.0394 0.0397 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0105 0.0094 0.0097
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0027 0.0012 0.004
Echinococcus granulosus hyperpolarization activated cyclic 0.0039 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0065 0.0052 0.0169
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0039 0.0125
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0027 0.0012 0.0012
Brugia malayi CXXC zinc finger family protein 0.0027 0.0012 0.0037
Loa Loa (eye worm) hypothetical protein 0.296 0.3087 1
Trypanosoma cruzi histone deacetylase, putative 0.0035 0.0021 0.0068
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0083 0.1831
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0035 0.002 0.0064
Schistosoma mansoni sodium/chloride dependent transporter 0.0366 0.0368 0.119
Plasmodium falciparum DNA topoisomerase 2 0.0165 0.0156 0.4111
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0105 0.0094 0.0304
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0036 0.0021 0.0069
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0026 0.0935
Leishmania major eukaryotic translation initiation factor-like protein 0.0044 0.0029 0.0095
Schistosoma mansoni hypothetical protein 0.019 0.0183 0.0591
Schistosoma mansoni endoplasmin 0.0165 0.0156 0.0505
Mycobacterium ulcerans two component regulator - sensor kinase 0.0165 0.0156 0.6191
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0083 0.1831
Schistosoma mansoni ap endonuclease 0.004 0.0026 0.0083
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0036 0.0021 0.0067
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0119 0.0108 0.6875
Echinococcus granulosus neuropeptide receptor 0.0394 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus multilocularis tar DNA binding protein 0.0117 0.0106 0.011
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0039 0.0024 0.0024
Plasmodium vivax DNA topoisomerase II, putative 0.0165 0.0156 0.4297
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0036 0.0021 0.0021
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0044 0.0029 0.1835
Echinococcus multilocularis sodium:hydrogen exchanger 0.0038 0.0023 0.0023
Brugia malayi Ets-domain containing protein 0.0038 0.0024 0.0075
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0039 0.0024 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0383 0.0386 0.0401
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0017 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0044 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus multilocularis cathepsin b 0.0084 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Schistosoma mansoni myosin xvIII 0.0394 0.0397 0.1285
Echinococcus multilocularis RUN 0.0361 0.0362 0.0377
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0039 0.0746
Mycobacterium leprae Probable lipase LipE 0.0062 0.0049 0.3105
Loa Loa (eye worm) G-protein coupled receptor 0.0394 0.0397 0.1286
Leishmania major hypothetical protein, conserved 0.0027 0.0012 0.004
Mycobacterium tuberculosis Probable reductase 0.0086 0.0073 0.1572
Onchocerca volvulus 0.0036 0.0021 0.0535
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Schistosoma mansoni nAChR subunit 0.0036 0.0021 0.0067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0126 0.0116 0.0375
Echinococcus granulosus mitogen activated protein kinase 11 0.0118 0.0108 0.0107
Schistosoma mansoni neuropeptide receptor 0.0394 0.0397 0.1285
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0148 0.0139 0.3611
Onchocerca volvulus 0.0027 0.0012 0.0301
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0044 0.0029 0.1835
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0031 0.0016 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0027 0.0012 0.0012
Echinococcus granulosus cGMP dependent protein kinase 1 0.0028 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0165 0.0156 1
Echinococcus granulosus g protein coupled receptor 0.0394 0.0397 0.0397
Leishmania major histone deacetylase, putative 0.0035 0.0021 0.0068
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Brugia malayi cathepsin B-like cysteine proteinase 0.0084 0.0072 0.0232
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0055 0.0041 0.0132
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0062 0.0049 0.3067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0394 0.0397 0.0413
Schistosoma mansoni vesicular amine transporter 0.002 0.0005 0.0014
Brugia malayi hypothetical protein 0.0057 0.0044 0.0141
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0036 0.0021 0.0067
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0073 0.1572
Schistosoma mansoni neuropeptide f receptor 76f 0.0394 0.0397 0.1285
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0165 0.0156 0.3939
Loa Loa (eye worm) ACC-1 protein 0.0036 0.0021 0.0069
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0036 0.0021 0.0067
Echinococcus multilocularis protein patched 0.0049 0.0035 0.0036
Mycobacterium leprae Probable two component sensor kinase MprB 0.0165 0.0156 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Echinococcus granulosus G protein coupled receptor 139 0.0394 0.0397 0.0397
Loa Loa (eye worm) fli-1 protein 0.0116 0.0105 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0394 0.0397 0.0397
Trypanosoma brucei heat shock protein 90, putative 0.0165 0.0156 0.0506
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Brugia malayi Ets-domain containing protein 0.0038 0.0024 0.0075
Echinococcus multilocularis mitogen activated protein kinase 14 0.0118 0.0108 0.0111
Onchocerca volvulus 0.0052 0.0039 0.0972
Loa Loa (eye worm) doublecortin family protein 0.0361 0.0362 0.1174
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Brugia malayi Dopamine receptor protein 2 0.0394 0.0397 0.1285
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0394 0.0397 0.1285
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.0156 0.0155
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0013 0.0041
Plasmodium vivax unspecified product 0.0028 0.0013 0.0334
Brugia malayi Cathepsin L-like precursor 0.0017 0.0001 0.0002
Echinococcus granulosus acetylcholinesterase 0.0059 0.0045 0.0045
Trypanosoma cruzi DNA topoisomerase II, putative 0.0165 0.0156 0.0506
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0394 0.0397 0.0413
Onchocerca volvulus 0.0361 0.0362 0.9131
Brugia malayi Muscleblind-like protein 0.0174 0.0166 0.0538
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0104 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0126 0.0116 0.0116
Brugia malayi Cathepsin L-like precursor 0.0052 0.0039 0.0124
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0023 0.0023
Mycobacterium tuberculosis Possible two component sensor kinase 0.0165 0.0156 0.3715
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0165 0.0156 0.0506
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0105 0.0094 0.0304
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Schistosoma mansoni lipoxygenase 0.0361 0.0362 0.1173
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0036 0.0021 0.0067
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0105 0.0094 0.0304
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0027 0.0012 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0055 0.0041 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0394 0.0397 0.0413
Entamoeba histolytica hypothetical protein 0.0098 0.0086 0.5406
Loa Loa (eye worm) TOPoisomerase family member 0.0165 0.0156 0.0506
Echinococcus granulosus patatin phospholipase domain containing protein 0.0027 0.0012 0.0012
Brugia malayi beta-lactamase family protein 0.0062 0.0049 0.0157
Leishmania major mitochondrial DNA topoisomerase II 0.0165 0.0156 0.0506
Echinococcus multilocularis histone deacetylase 7 0.0035 0.0021 0.0021
Brugia malayi G protein-coupled receptor F59B2.13 0.0394 0.0397 0.1285
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0273 0.027 0.027
Echinococcus multilocularis neuropeptides capa receptor 0.0394 0.0397 0.0413
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.0038 0.0023 0.0074
Brugia malayi follicle stimulating hormone receptor 0.061 0.0623 0.2017
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0031 0.0016 0.0015
Echinococcus multilocularis hyperpolarization activated cyclic 0.0039 0.0024 0.0024
Trichomonas vaginalis esterase, putative 0.0062 0.0049 0.3067
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0062 0.0049 0.0939
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.014 0.0453
Brugia malayi Histone deacetylase family protein 0.0035 0.0021 0.0066
Trypanosoma brucei cysteine peptidase C (CPC) 0.0034 0.0019 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0117 0.0106 0.0343
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0025
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0118 0.0108 0.0349
Echinococcus granulosus glycine receptor subunit alpha 1 0.0036 0.0021 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0013 0.0655
Leishmania major protein kinase, putative 0.0028 0.0013 0.0042
Echinococcus granulosus cGMP dependent protein kinase 0.0028 0.0013 0.0013
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0038 0.0023 0.0074
Echinococcus granulosus sex peptide receptor 0.0394 0.0397 0.0397
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0126 0.0116 0.012
Echinococcus granulosus neuropeptide Y receptor 0.0394 0.0397 0.0397
Echinococcus multilocularis voltage gated potassium channel 0.0055 0.0041 0.0042
Leishmania major hypothetical protein, conserved 0.0027 0.0012 0.004
Echinococcus granulosus voltage gated potassium channel 0.0055 0.0041 0.0041
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0039 0.2418
Brugia malayi hypothetical protein 0.0017 0.0001 0.0002
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0394 0.0397 0.1285
Brugia malayi neuropeptide F receptor 0.0394 0.0397 0.1285
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0165 0.0156 0.3715
Onchocerca volvulus 0.0036 0.0021 0.0535
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0105 0.0094 0.0304
Echinococcus granulosus orexin receptor type 2 0.0394 0.0397 0.0397
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.1035 0.1069 0.8595
Brugia malayi Doublecortin family protein 0.0361 0.0362 0.1173
Schistosoma mansoni growth hormone secretagogue receptor 0.0394 0.0397 0.1285
Brugia malayi acetyltransferase, GNAT family protein 0.0131 0.0121 0.039
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0026 0.0026
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0036 0.0021 0.0067
Brugia malayi Fli-1 protein 0.0116 0.0105 0.0338
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0035 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.0055 0.0041 0.0132
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0088 0.0076 0.0244
Giardia lamblia Pms1-like protein 0.0165 0.0156 1
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0065
Loa Loa (eye worm) translation initiation factor 4E 0.0044 0.0029 0.0095
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Echinococcus multilocularis expressed conserved protein 0.0108 0.0097 0.01
Plasmodium vivax hypothetical protein, conserved 0.0165 0.0156 0.4297
Onchocerca volvulus 0.0394 0.0397 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0118 0.0108 0.0349
Onchocerca volvulus 0.0394 0.0397 1
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0165 0.0156 0.9876
Toxoplasma gondii ABC1 family protein 0.0062 0.0049 0.0296
Echinococcus multilocularis g protein coupled receptor 0.0394 0.0397 0.0413
Loa Loa (eye worm) matrixin family protein 0.0084 0.0072 0.0232
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0039 0.0039
Brugia malayi Melatonin receptor type 1A 0.0394 0.0397 0.1285
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0394 0.0397 0.0413
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0165 0.0156 0.6191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0013 0.0043
Schistosoma mansoni tyrosine kinase 0.0185 0.0178 0.0574
Trypanosoma cruzi heat shock protein 90, putative 0.0165 0.0156 0.0506
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Onchocerca volvulus 0.0036 0.0021 0.0535
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0036 0.0021 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0039 0.0125
Leishmania major regulatory subunit of protein kinase a-like protein 0.0027 0.0012 0.004
Brugia malayi putative neuropeptide receptor 0.0394 0.0397 0.1285
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0039 0.0024 0.0078
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0165 0.0156 0.0506
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0036 0.0021 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0024 0.1497
Leishmania major protein kinase, putative 0.0028 0.0013 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0394 0.0397 0.1285
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0039 0.0125
Giardia lamblia Rrm3p helicase 0.0028 0.0013 0.0043
Echinococcus granulosus lamin 0.0023 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Echinococcus multilocularis protein dispatched 1 0.0056 0.0043 0.0043
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0036 0.0021 0.0021
Schistosoma mansoni histone deacetylase hda2 0.0041 0.0027 0.0085
Loa Loa (eye worm) RNA binding protein 0.0117 0.0106 0.0344
Echinococcus multilocularis muscleblind protein 1 0.0174 0.0166 0.0173
Giardia lamblia Histone acetyltransferase GCN5 0.0035 0.0021 0.057
Loa Loa (eye worm) hypothetical protein 0.0321 0.032 0.1038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Giardia lamblia Cathepsin B precursor 0.0034 0.0019 0.0479
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Brugia malayi G protein-coupled receptor 0.0394 0.0397 0.1285
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0131 0.0121 0.0125
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0165 0.0156 0.3939
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0394 0.0397 0.1286
Echinococcus granulosus biogenic amine 5HT receptor 0.0586 0.0598 0.0598
Schistosoma mansoni amine GPCR 0.0394 0.0397 0.1285
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0394 0.0397 0.1285
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0044 0.0899
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0021 0.0067
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0027 0.0012 0.0039
Mycobacterium ulcerans hydrolase 0.0042 0.0028 0.0665
Echinococcus multilocularis neuropeptide receptor A26 0.0394 0.0397 0.0413
Schistosoma mansoni endoplasmin 0.0165 0.0156 0.0505
Echinococcus multilocularis transfer RNA-Gly 0.0038 0.0023 0.0023
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0105 0.0094 0.0097
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0394 0.0397 0.0413
Brugia malayi hypothetical protein 0.0098 0.0086 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0165 0.0156 0.9876
Echinococcus multilocularis non capsid protein NS 1 0.0018 0.0003 0.0002
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0105 0.0094 0.0305
Plasmodium vivax vivapain-1 0.0028 0.0013 0.0334
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0394 0.0397 0.0397
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0105 0.0094 0.0305
Schistosoma mansoni amine GPCR 0.0804 0.0826 0.2675
Trypanosoma brucei Flagellar Member 6 0.0027 0.0012 0.004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0394 0.0397 0.1285
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0105 0.0094 0.0304
Loa Loa (eye worm) hypothetical protein 0.0275 0.0272 0.088
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0049 0.0158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.0038 0.0023 0.0076
Echinococcus multilocularis nAChR subunit 0.0036 0.0021 0.0021
Echinococcus granulosus allatostatin A receptor 0.0394 0.0397 0.0397
Brugia malayi Probable DNA topoisomerase II 0.0165 0.0156 0.0505
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0165 0.0156 0.3715
Mycobacterium tuberculosis Probable two component sensor kinase 0.0165 0.0156 0.3715
Echinococcus granulosus lipoxygenase domain containing protein 0.0361 0.0362 0.0362
Entamoeba histolytica DNA repair and recombination protein, putative 0.0028 0.0013 0.0654
Echinococcus multilocularis cathepsin L 0.0028 0.0013 0.0013
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0065 0.0052 0.0168
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Trichomonas vaginalis receptor histidine kinase, putative 0.0165 0.0156 0.9876
Schistosoma mansoni histone deacetylase 4 5 0.0035 0.0021 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Leishmania major hypothetical protein, conserved 0.0062 0.0049 0.0158
Echinococcus multilocularis cpg binding protein 0.0028 0.0014 0.0013
Trypanosoma brucei heat shock protein, putative 0.0165 0.0156 0.0506
Schistosoma mansoni heat shock protein 0.0165 0.0156 0.0505
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0038 0.0024 0.0094
Echinococcus multilocularis lamin 0.0023 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0021 0.1318
Loa Loa (eye worm) hypothetical protein 0.0366 0.0368 0.1191
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0039 0.0125
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0028 0.0013 0.0042
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0013 0.0655
Schistosoma mansoni hypothetical protein 0.0028 0.0013 0.0041
Onchocerca volvulus 0.0036 0.0021 0.0535
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0026 0.0384
Echinococcus granulosus poly ADP ribose polymerase 1 0.0119 0.0108 0.0108
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0062 0.0049 0.0157
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0012 0.0765
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0063 0.005 0.1356
Entamoeba histolytica cysteine protease, putative 0.0052 0.0039 0.2317
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0126 0.0116 0.0376
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0013 0.0043
Echinococcus granulosus histone acetyltransferase KAT2B 0.0127 0.0117 0.0117
Schistosoma mansoni pyruvate dehydrogenase 0.2796 0.2915 0.9441
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Trypanosoma cruzi Flagellar Member 6 0.0027 0.0012 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0001 0.0003
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.0156 0.0161
Trypanosoma cruzi cAMP response protein 1, putative 0.0027 0.0012 0.004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0394 0.0397 0.1286
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Trypanosoma brucei heat shock protein, putative 0.0165 0.0156 0.0506
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0039 0.0024 0.0078
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0165 0.0156 0.9876
Echinococcus granulosus tar DNA binding protein 0.0117 0.0106 0.0106
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0463 0.0469 0.1518
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0012 0.0039
Leishmania major cathepsin L-like protease 0.0052 0.0039 0.0125
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0028 0.0013 0.0013
Trypanosoma brucei poly(adp-ribose) polymerase 0.0065 0.0052 0.0169
Trichomonas vaginalis penicillin-binding protein, putative 0.0062 0.0049 0.3067
Echinococcus multilocularis muscleblind protein 0.0174 0.0166 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0165 0.0156 0.3715
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0165 0.0156 0.3715
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0124 0.0113 0.0821
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0038 0.0023 0.0023
Echinococcus granulosus GA binding protein alpha chain 0.0038 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.0125
Echinococcus granulosus cathepsin L 0.0028 0.0013 0.0013
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0148 0.0139 0.3611
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Echinococcus granulosus beta LACTamase domain containing family member 0.0062 0.0049 0.0048
Trypanosoma brucei cAMP binding protein, putative 0.0027 0.0012 0.004
Schistosoma mansoni biogenic amine (5HT) receptor 0.0394 0.0397 0.1285
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0165 0.0156 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0039 0.0038
Echinococcus multilocularis conserved hypothetical protein 0.9159 0.9587 1
Schistosoma mansoni hypothetical protein 0.0149 0.014 0.0453
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0105 0.0094 0.0094
Echinococcus granulosus serotonin transporter 0.0366 0.0368 0.0367
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0036 0.0021 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0118 0.0108 0.0349
Loa Loa (eye worm) hypothetical protein 0.0233 0.0228 0.074
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Schistosoma mansoni opsin-like receptor 0.0394 0.0397 0.1285
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0038 0.0024 0.0076
Onchocerca volvulus Matrix metalloproteinase homolog 0.0077 0.0064 0.1618
Giardia lamblia Sodium/hydrogen exchanger 3 0.0038 0.0023 0.0755
Echinococcus granulosus tm gpcr rhodopsin 0.0394 0.0397 0.0397
Leishmania major histone deacetylase, putative 0.0035 0.0021 0.0068
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0063 0.005 0.2612
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0178 0.017 0.055
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0036 0.0021 0.0067
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0036 0.0021 0.0067
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0012 0.0765
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0105 0.0094 0.0666
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0165 0.0156 0.3715
Brugia malayi Probable ATP-dependent helicase DHX35 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0115
Echinococcus multilocularis non capsid protein NS 1 0.0018 0.0003 0.0002
Schistosoma mansoni nAChR subunit 0.0036 0.0021 0.0067
Echinococcus multilocularis survival motor neuron protein 1 0.0731 0.0751 0.0782
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0027
Schistosoma mansoni pyruvate dehydrogenase 0.2796 0.2915 0.9441
Echinococcus granulosus biogenic amine 5HT receptor 0.0394 0.0397 0.0397
Schistosoma mansoni lamin 0.0023 0.0008 0.0026
Loa Loa (eye worm) glutathione reductase 0.0037 0.0023 0.0075
Echinococcus granulosus histone deacetylase 6 0.0035 0.0021 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0394 0.0397 0.0413
Echinococcus granulosus 7tm_1 domain containing protein 0.0394 0.0397 0.0397
Loa Loa (eye worm) MH2 domain-containing protein 0.0173 0.0166 0.0536
Mycobacterium leprae PROBABLE HYDROLASE 0.0042 0.0028 0.1765
Loa Loa (eye worm) hypothetical protein 0.0537 0.0547 0.1772
Trichomonas vaginalis sensor histidine kinase, putative 0.0165 0.0156 0.9876
Loa Loa (eye worm) matrix metalloproteinase 0.0035 0.002 0.0065
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0165 0.0156 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0013 0.0805
Echinococcus granulosus neuropeptide receptor A26 0.0394 0.0397 0.0397
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0004 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.1035 0.1069 0.3462
Brugia malayi Matrixin family protein 0.0035 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Schistosoma mansoni hypothetical protein 0.0048 0.0034 0.0107
Loa Loa (eye worm) hypothetical protein 0.0059 0.0045 0.0146
Echinococcus granulosus neuropeptides capa receptor 0.0394 0.0397 0.0397
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0001 0.0002
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0165 0.0156 0.3939
Echinococcus granulosus tm gpcr rhodopsin 0.1698 0.1764 0.1764
Schistosoma mansoni ap endonuclease 0.004 0.0026 0.0083
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0062 0.0049 0.0939
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0038 0.0023 0.0588
Brugia malayi hypothetical protein 0.0105 0.0094 0.0304
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0008 0.0027
Brugia malayi cathepsin L-like precursor 0.0036 0.0021 0.0067
Trypanosoma cruzi heat shock protein 85, putative 0.0165 0.0156 0.0506
Echinococcus granulosus nAChR subunit 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0038 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0366 0.0368 0.1191
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0036 0.0021 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0062 0.0049 0.3067
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Schistosoma mansoni tar DNA-binding protein 0.0117 0.0106 0.0343
Plasmodium falciparum DNA gyrase subunit B 0.0165 0.0156 0.4111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Brugia malayi WGR domain containing protein 0.0065 0.0052 0.0168
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0026 0.0083
Trichomonas vaginalis heat shock protein, putative 0.0165 0.0156 0.9876
Onchocerca volvulus Matrilysin homolog 0.0077 0.0064 0.1618
Echinococcus granulosus glycine receptor subunit alpha 1 0.0036 0.0021 0.0021
Schistosoma mansoni cpg binding protein 0.0028 0.0014 0.0043
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0049 0.1322
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0394 0.0397 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0021 0.1318
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0039 0.0746
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Trypanosoma cruzi cAMP response protein 1 0.0027 0.0012 0.004
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0036 0.0021 0.0021
Echinococcus multilocularis cysteine protease 0.0052 0.0039 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0394 0.0397 0.0397
Loa Loa (eye worm) histone deacetylase 0.0035 0.0021 0.0068
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0013 0.0018
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0394 0.0397 0.0413
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0017 0.0001 0.0002
Echinococcus multilocularis mitogen activated protein kinase 11 0.0118 0.0108 0.0111
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.005
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0044 0.0142
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0027 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0167 0.0158 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0083 0.1831
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0063 0.005 0.1074
Loa Loa (eye worm) TYRA-2 protein 0.0394 0.0397 0.1286
Leishmania major hypothetical protein, conserved 0.0165 0.0156 0.0506
Echinococcus multilocularis lamin dm0 0.0023 0.0008 0.0008
Mycobacterium ulcerans lipase LipD 0.0062 0.0049 0.1564
Brugia malayi Cathepsin L-like precursor 0.0052 0.0039 0.0124
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.296 0.3087 1
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.1035 0.1069 0.3462
Schistosoma mansoni biogenic amine receptor 0.0394 0.0397 0.1285
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0165 0.0156 0.4051
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0165 0.0156 0.0506
Echinococcus granulosus cathepsin b 0.0084 0.0072 0.0072
Brugia malayi hypothetical protein 0.0017 0.0001 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0394 0.0397 0.1285
Onchocerca volvulus 0.0394 0.0397 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0027 0.0012 0.0039
Onchocerca volvulus 0.0023 0.0008 0.0209
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0165 0.0156 0.4111
Schistosoma mansoni pyruvate dehydrogenase 0.296 0.3087 1
Brugia malayi hypothetical protein 0.0017 0.0001 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0012 0.0039
Echinococcus granulosus poly (ADP ribose) polymerase 0.0018 0.0003 0.0003
Onchocerca volvulus 0.0105 0.0094 0.2375
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0044 0.0029 0.1835
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0013 0.0655
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0038 0.0024 0.0636
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0119 0.0108 0.0112
Echinococcus granulosus poly (ADP ribose) polymerase 0.0037 0.0022 0.0022
Plasmodium vivax DNA gyrase subunit B, putative 0.0165 0.0156 0.4297
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0038 0.0024 0.1497
Brugia malayi RNA recognition motif domain containing protein 0.0117 0.0106 0.0343
Brugia malayi latrophilin 2 splice variant baaae 0.019 0.0183 0.0591
Echinococcus multilocularis somatostatin receptor 0.0394 0.0397 0.0413
Echinococcus multilocularis GPCR, family 2 0.0088 0.0076 0.0078
Schistosoma mansoni cpg binding protein 0.0027 0.0012 0.0037
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0394 0.0397 0.0413
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0036 0.0021 0.0021
Plasmodium vivax histone deacetylase, putative 0.0035 0.0021 0.0547
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0026 0.0084
Trypanosoma brucei heat shock protein, putative 0.0165 0.0156 0.0506
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0044 0.0256
Trypanosoma cruzi heat shock protein 90, putative 0.0165 0.0156 0.0506
Brugia malayi beta-lactamase family protein 0.0062 0.0049 0.0157
Schistosoma mansoni amine GPCR 0.0394 0.0397 0.1285
Echinococcus granulosus carboxylesterase 5A 0.0059 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0039 0.0125
Echinococcus multilocularis fmrfamide receptor 0.0394 0.0397 0.0413
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0021 0.0067
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Schistosoma mansoni cathepsin s 0.0017 0.0001 0.0002
Loa Loa (eye worm) endoplasmin 0.0165 0.0156 0.0506
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0021 0.1184
Mycobacterium ulcerans hypothetical protein 0.0062 0.0049 0.1564
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0039 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0765
Loa Loa (eye worm) latrophilin receptor protein 2 0.0088 0.0076 0.0246
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0028 0.0013 0.0042
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0105 0.0094 0.0304
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Plasmodium falciparum endoplasmin, putative 0.0165 0.0156 0.4111
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0072 0.0232
Loa Loa (eye worm) beta-lactamase 0.0062 0.0049 0.0158
Echinococcus granulosus g-protein coupled receptor 0.0394 0.0397 0.0397
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0178 0.017 0.0552
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0148 0.0139 0.8785
Echinococcus granulosus poly (ADP ribose) polymerase 0.0018 0.0003 0.0003
Schistosoma mansoni lamin 0.0023 0.0008 0.0026
Plasmodium vivax multidomain scavenger receptor, putative 0.0361 0.0362 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0027 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Onchocerca volvulus 0.0394 0.0397 1
Echinococcus multilocularis serotonin receptor 0.0586 0.0598 0.0623
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0105 0.0094 0.0304
Brugia malayi kinase, mitochondrial precursor 0.296 0.3087 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0042 0.0028 0.0089
Echinococcus multilocularis glycine receptor subunit beta 0.0036 0.0021 0.0021
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0042 0.0028 0.0399
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0027 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0114
Trypanosoma brucei histone deacetylase 3 0.0035 0.0021 0.0068
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0394 0.0397 0.1285
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0036 0.0021 0.0021
Entamoeba histolytica heat shock protein 90, putative 0.0165 0.0156 1
Loa Loa (eye worm) neuropeptide F receptor 0.0394 0.0397 0.1286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0039 0.2418
Loa Loa (eye worm) cysteine protease 0.0052 0.0039 0.0125
Leishmania major cathepsin L-like protease 0.0052 0.0039 0.0125
Onchocerca volvulus 0.0036 0.0021 0.0535
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Echinococcus granulosus muscleblind protein 0.0174 0.0166 0.0166
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0321 0.032 0.1038
Echinococcus multilocularis histone deacetylase 6 0.0041 0.0027 0.0027
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0004 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0013 0.0804
Schistosoma mansoni acetylcholine receptor-related 0.0017 0.0001 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0088 0.0076 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.004
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0148 0.0139 0.0449
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0165 0.0156 0.6191
Brugia malayi WGR domain containing protein 0.0119 0.0108 0.035
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0031
Toxoplasma gondii hypothetical protein 0.0105 0.0094 0.0666
Loa Loa (eye worm) hypothetical protein 0.0361 0.0362 0.1174
Loa Loa (eye worm) hypothetical protein 0.0105 0.0094 0.0305
Echinococcus multilocularis g protein coupled receptor 0.0394 0.0397 0.0413
Mycobacterium tuberculosis Probable lipase LipE 0.0062 0.0049 0.0939
Echinococcus granulosus neuropeptide receptor 0.0394 0.0397 0.0397
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0049 0.0158
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Echinococcus granulosus somatostatin receptor 0.0394 0.0397 0.0397
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.296 0.3087 0.322
Schistosoma mansoni nAChR subunit 0.0036 0.0021 0.0067
Loa Loa (eye worm) ctsf protein 0.0052 0.0039 0.0125
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0072 0.0232
Echinococcus multilocularis neuropeptide Y receptor 0.0394 0.0397 0.0413
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0073 0.468
Echinococcus multilocularis hyperpolarization activated cyclic 0.0039 0.0024 0.0024
Toxoplasma gondii heat shock protein 90, putative 0.0165 0.0156 0.1171
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0394 0.0397 0.1285
Onchocerca volvulus 0.0105 0.0094 0.2375
Trypanosoma brucei DNA topoisomerase ii 0.0165 0.0156 0.0506
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0036 0.0021 0.0021
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0044 0.0029 0.0095
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0165 0.0156 0.6191
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0044 0.0142
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0036 0.0021 0.0067
Onchocerca volvulus 0.0394 0.0397 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0028 0.0013 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.0104 0.0336
Brugia malayi Tachykinin-like peptides receptor 99D 0.0394 0.0397 0.1285
Echinococcus granulosus dnaJ subfamily B 0.0383 0.0386 0.0385
Toxoplasma gondii hypothetical protein 0.0105 0.0094 0.0666
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0165 0.0156 0.6191
Schistosoma mansoni neuropeptide F-like receptor 0.0394 0.0397 0.1285
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0013 0.0655
Echinococcus granulosus 7TM GPCR rhodopsin 0.0394 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Schistosoma mansoni opsin-like receptor 0.0394 0.0397 0.1285
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0394 0.0397 0.1285
Brugia malayi Carboxylesterase family protein 0.0059 0.0045 0.0145
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0019 0.0004 0.0011
Echinococcus granulosus histone deacetylase 0.0035 0.0021 0.002
Schistosoma mansoni sodium-dependent amino acid transporter 0.0105 0.0094 0.0304
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Brugia malayi Matrixin family protein 0.0035 0.002 0.0064
Trypanosoma brucei histone deacetylase 4 0.0035 0.0021 0.0068
Schistosoma mansoni histone deacetylase 4 5 0.0035 0.0021 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0126 0.0116 0.012
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Trichomonas vaginalis DNA topoisomerase II, putative 0.0165 0.0156 0.9876
Echinococcus granulosus 5'partial|3'partial|non capsid protein NS 1 0.0018 0.0003 0.0002
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0028 0.0013 0.0004
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0036 0.0021 0.0069
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0036 0.0021 0.0021
Plasmodium vivax vivapain-2 0.0052 0.0039 0.1038
Loa Loa (eye worm) hypothetical protein 0.0731 0.0751 0.2431
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0024 0.1522
Schistosoma mansoni hypothetical protein 0.0088 0.0076 0.0244
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0098 0.0086 0.0089
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0178 0.017 0.017
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.0035 0.0036
Mycobacterium tuberculosis Probable esterase LipL 0.0062 0.0049 0.0939
Onchocerca volvulus 0.0394 0.0397 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0008 0.0027
Brugia malayi Latrophilin receptor protein 2 0.0088 0.0076 0.0244
Echinococcus granulosus survival motor neuron protein 1 0.0731 0.0751 0.075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0278 0.0275 0.0889
Loa Loa (eye worm) heat shock protein 90 0.0165 0.0156 0.0506
Mycobacterium ulcerans short chain dehydrogenase 0.0249 0.0245 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0105 0.0094 0.0304
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.0013 0.0042
Onchocerca volvulus 0.0035 0.002 0.0504
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0394 0.0397 0.0397
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0039 0.0039
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0038 0.0024 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0165 0.0156 0.3715
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0165 0.0156 0.0505
Plasmodium falciparum glutathione reductase 0.0037 0.0023 0.0301
Onchocerca volvulus 0.0366 0.0368 0.9262
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0039 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0383 0.0386 0.1248
Plasmodium vivax amine transporter, putative 0.0105 0.0094 0.2579
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0021 0.0067
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0013 0.0041
Toxoplasma gondii cathepsin CPL 0.0052 0.0039 0.0212
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0076
Plasmodium falciparum histone deacetylase 2 0.0035 0.0021 0.0239
Loa Loa (eye worm) histone deacetylase 7A 0.0035 0.0021 0.0068
Leishmania major hypothetical protein, unknown function 0.0027 0.0012 0.004
Trypanosoma brucei heat shock protein, putative 0.0165 0.0156 0.0506
Echinococcus granulosus GPCR family 2 0.0088 0.0076 0.0075
Plasmodium falciparum histone acetyltransferase GCN5 0.0035 0.0021 0.0234
Echinococcus multilocularis g protein coupled receptor 0.0394 0.0397 0.0413
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Trypanosoma brucei cAMP response protein 1, putative 0.0027 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0013
Toxoplasma gondii preprocathepsin c precursor, putative 0.0148 0.0139 0.1029
Echinococcus granulosus neuropeptides capa receptor 0.0394 0.0397 0.0397
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0126 0.0116 0.012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0072 0.0232
Brugia malayi Cathepsin L-like precursor 0.0052 0.0039 0.0124
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.296 0.3087 0.322
Plasmodium falciparum LCCL domain-containing protein 0.0361 0.0362 1
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Schistosoma mansoni hypothetical protein 0.0088 0.0076 0.0244
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0165 0.0156 0.0505
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0001 0.0003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0394 0.0397 0.0413
Mycobacterium ulcerans beta-lactamase 0.0062 0.0049 0.1564
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0026 0.0379
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0165 0.0156 1
Echinococcus multilocularis non capsid protein NS 1 0.0018 0.0003 0.0002
Brugia malayi hypothetical protein 0.0394 0.0397 0.1285
Leishmania major C-8 sterol isomerase-like protein 0.0537 0.0547 0.1772
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0044 0.0029 0.1716
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0028 0.0013 0.0012
Brugia malayi sulfakinin receptor protein 0.0545 0.0555 0.1797
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0041 0.0228
Schistosoma mansoni sodium/chloride dependent transporter 0.0321 0.032 0.1037
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0004 0.0011
Trypanosoma cruzi histone deacetylase, putative 0.0035 0.0021 0.0068
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Onchocerca volvulus 0.0019 0.0004 0.0099
Echinococcus granulosus nAChR subunit 0.0019 0.0004 0.0004
Loa Loa (eye worm) ACC-1 protein 0.0036 0.0021 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Brugia malayi Cyclic-nucleotide gated cation channel 0.0039 0.0024 0.0078
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0039 0.0972
Trypanosoma brucei histone deacetylase, putative 0.0035 0.0021 0.0068
Plasmodium vivax vivapain-2 0.0052 0.0039 0.1038
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0167 0.0158 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0023 0.0301
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0036 0.0021 0.0021
Echinococcus multilocularis neuropeptide Y receptor 0.0394 0.0397 0.0413
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0394 0.0397 0.0397
Echinococcus granulosus fmrfamide receptor 0.0394 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0003
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Echinococcus multilocularis neuropeptide FF receptor 2 0.0394 0.0397 0.0413
Schistosoma mansoni hypothetical protein 0.0027 0.0012 0.0039
Brugia malayi Cathepsin L-like precursor 0.0052 0.0039 0.0124
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0044 0.0029 0.1716
Loa Loa (eye worm) DEAH box polypeptide 35 0.0016 0.0001 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0194 0.0187 0.0604
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Loa Loa (eye worm) hypothetical protein 0.0463 0.0469 0.1519
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0013 0.0041
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0165 0.0156 0.0506
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0036 0.0021 0.0021
Echinococcus multilocularis transfer RNA-Gly 0.0038 0.0023 0.0023
Toxoplasma gondii exonuclease III APE 0.004 0.0026 0.0109
Echinococcus granulosus hyperpolarization activated cyclic 0.0039 0.0024 0.0024
Schistosoma mansoni nAChR subunit 0.0017 0.0001 0.0002
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0027 0.0012 0.0012
Brugia malayi Serotonin receptor 0.0394 0.0397 0.1285
Brugia malayi translation initiation factor 4E 0.0044 0.0029 0.0094
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0027 0.0012 0.0012
Onchocerca volvulus 0.0052 0.0039 0.0972
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0394 0.0397 0.1286
Onchocerca volvulus 0.0062 0.0049 0.123
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0008
Trypanosoma cruzi DNA topoisomerase II, putative 0.0165 0.0156 0.0506
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0036 0.0021 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0394 0.0397 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0039 0.0125
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0026 0.0084
Brugia malayi Carboxylesterase family protein 0.0059 0.0045 0.0145
Brugia malayi putative neuropeptide receptor NPR1 0.0394 0.0397 0.1285
Echinococcus multilocularis beta LACTamase domain containing family member 0.0062 0.0049 0.005
Leishmania major cathepsin L-like protease 0.0052 0.0039 0.0125
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0008 0.0026
Echinococcus granulosus histone deacetylase 6 0.0041 0.0027 0.0026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0021 0.0067
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0036 0.0021 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0062 0.0049 0.3105
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0034 0.0019 0.0063
Schistosoma mansoni nAChR subunit 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0158
Onchocerca volvulus 0.0105 0.0094 0.2375
Entamoeba histolytica cysteine protease, putative 0.0028 0.0013 0.0655
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0027 0.0012 0.0012
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0165 0.0156 0.3715
Toxoplasma gondii heat shock protein HSP90 0.0165 0.0156 0.1171
Echinococcus multilocularis G protein coupled receptor 139 0.0394 0.0397 0.0413
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0165 0.0156 0.0506
Schistosoma mansoni survival motor neuron protein 0.0149 0.014 0.0453
Chlamydia trachomatis DNA gyrase subunit B 0.0165 0.0156 0.1364
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0036 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0044 0.0029 0.0095
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0063 0.005 0.2612
Echinococcus multilocularis carboxylesterase 5A 0.0059 0.0045 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0044 0.0899
Leishmania major developmentally regulated phosphoprotein-like protein 0.296 0.3087 1
Leishmania major cathepsin L-like protease 0.0052 0.0039 0.0125
Onchocerca volvulus 0.0394 0.0397 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0026 0.1617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0039 0.2418
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0012 0.0774
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Schistosoma mansoni loxhd1 0.0361 0.0362 0.1173
Giardia lamblia Cathepsin B precursor 0.0034 0.0019 0.0479
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0021 0.0067
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0035 0.0036
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Brugia malayi Histone deacetylase family protein 0.0035 0.0021 0.0066
Loa Loa (eye worm) norepinephrine transporter 0.0366 0.0368 0.1191
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus multilocularis non capsid protein NS 1 0.0038 0.0023 0.0023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0573 0.0585 0.0609
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0027 0.0012 0.0765
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0026 0.1491
Leishmania major cyclic nucleotide-binding protein-like protein 0.0027 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0321 0.032 0.1038
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0001 0.0003
Trypanosoma brucei heat shock protein, putative 0.0165 0.0156 0.0506
Echinococcus granulosus glycine receptor subunit beta 0.0036 0.0021 0.0021
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0117 0.0106 0.0342
Trypanosoma cruzi histone deacetylase, putative 0.0035 0.0021 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0013 0.0043
Onchocerca volvulus 0.0394 0.0397 1
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0024 0.0078
Leishmania major heat shock protein 83-1 0.0165 0.0156 0.0506
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0013 0.0013
Brugia malayi G-protein coupled receptor 0.0394 0.0397 0.1285
Loa Loa (eye worm) hypothetical protein 0.0115 0.0104 0.0337
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0105 0.0094 0.0666
Brugia malayi Thioredoxin reductase 0.0037 0.0023 0.0073
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0038 0.0023 0.0023
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0013 0.0655
Brugia malayi hypothetical protein 0.0037 0.0023 0.0072
Schistosoma mansoni cpg binding protein 0.0028 0.0014 0.0043
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0065 0.0052 0.0169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0013 0.0041
Trypanosoma brucei C-8 sterol isomerase, putative 0.0537 0.0547 0.1772
Brugia malayi Egg laying defective protein 4 0.0028 0.0013 0.0041
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0126 0.0116 0.0115
Schistosoma mansoni hypothetical protein 0.0394 0.0397 0.1285
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.12 0.1241 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0039 0.0125
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0044 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0394 0.0397 0.1286
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0039 0.0024 0.0024
Brugia malayi neuropeptide F receptor 0.0394 0.0397 0.1285
Schistosoma mansoni tar DNA-binding protein 0.0117 0.0106 0.0343
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0039 0.2317
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0069
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0026 0.0084

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 184 nM Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs ChEMBL. 22871582
IC50 (binding) = 184 nM Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation counting ChEMBL. 23062820
IC50 (functional) = 381 nM Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation after 30 mins by enzyme immunoassay ChEMBL. 22871582
IC50 (functional) = 381 nM Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated for 30 mins before CRF addition measured after 30 mins by enzyme immunoassay ChEMBL. 23062820

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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