Detailed information for compound 1698552

Basic information

Technical information
  • TDR Targets ID: 1698552
  • Name: 2-[1-ethyl-4-(phenylmethyl)-4,9-dihydro-3H-py rano[3,4-b]indol-1-yl]acetic acid
  • MW: 349.423 | Formula: C22H23NO3
  • H donors: 2 H acceptors: 2 LogP: 3.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1(OCC(c2c1[nH]c1c2cccc1)Cc1ccccc1)CC(=O)O
  • InChi: 1S/C22H23NO3/c1-2-22(13-19(24)25)21-20(17-10-6-7-11-18(17)23-21)16(14-26-22)12-15-8-4-3-5-9-15/h3-11,16,23H,2,12-14H2,1H3,(H,24,25)
  • InChiKey: BUUODSZYUAZDIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-(benzyl)-1-ethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl]acetic acid
  • 2-[1-ethyl-4-(phenylmethyl)-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl]ethanoic acid
  • 114030-44-3
  • DEXPEMEDOLAC
  • Dexpemedolac [USAN:INN]
  • Pyrano(3,4-b)indole-1-acetic acid, 1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)-, (1S-cis)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0007 0.0024
Echinococcus multilocularis high voltage activated calcium channel beta 0.002 0.0005 0.0016
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0018 0.0001 0.0001
Giardia lamblia Rab geranylgeranyltransferase 0.004 0.0051 0.0161
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.0333 0.4865
Echinococcus multilocularis Ankyrin 0.003 0.0028 0.0097
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.004 0.0051 0.0176
Echinococcus granulosus glycine receptor subunit beta 0.018 0.0366 0.128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0059 0.0092 0.0091
Giardia lamblia Alanyl dipeptidyl peptidase 0.003 0.0028 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.0178
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.032 0.0683 0.1196
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.0071 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.0333 1
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.0578 0.2021
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.032 0.0683 0.2387
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0014 0.0389
Loa Loa (eye worm) calpain family protein 1 0.004 0.005 0.0048
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0083 0.0147 0.0146
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.032 0.0683 0.2389
Onchocerca volvulus 0.0033 0.0034 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0051 0.0173
Schistosoma mansoni cell polarity protein 0.0027 0.0022 0.0037
Brugia malayi Sodium:solute symporter family protein 0.0082 0.0146 0.0145
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0054 0.0186
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0155 0.031 0.107
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0014 0.0568
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0087 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0029 0.0099
Echinococcus multilocularis Furin 1 0.0018 0.0001 0.0003
Trypanosoma cruzi guanylate kinase, putative 0.002 0.0005 0.0013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Toxoplasma gondii subtilisin SUB9 0.0018 0.0001 0.0047
Trypanosoma cruzi trypanothione synthetase, putative 0.0044 0.0059 0.0201
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.0009 0.0015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0061 0.0107
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0071 0.0244
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0014 0.0045
Plasmodium vivax guanylate kinase, putative 0.002 0.0005 0.0013
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0054 0.0186
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0054 0.0053
Loa Loa (eye worm) transcriptional regulator 0.0049 0.0071 0.007
Leishmania major DNA polymerase kappa, putative 0.0041 0.0054 0.0183
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0082 0.0146 0.5911
Echinococcus multilocularis calpain family protein 1, d 0.004 0.005 0.0172
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0014 0.0045
Trypanosoma brucei protein kinase, putative 0.006 0.0095 0.0328
Echinococcus multilocularis prolyl endopeptidase 0.003 0.0028 0.0096
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.003 0.0028 0.0093
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0095 0.0328
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0038 0.0127
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0095 0.0331
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.018 0.0366 0.0641
Trypanosoma brucei prolyl oligopeptidase, putative 0.003 0.0028 0.0093
Brugia malayi Cation transporter family protein 0.018 0.0366 0.0365
Toxoplasma gondii exonuclease III APE 0.0021 0.0007 0.0293
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.0386 0.0385
Plasmodium falciparum plasmepsin VII 0.0022 0.0011 0.0033
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0028 0.0081
Giardia lamblia CDC72 0.1282 0.2858 1
Schistosoma mansoni mannosidase endo-alpha 0.002 0.0005 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0119 0.3538
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0095 0.0328
Echinococcus multilocularis cpg binding protein 0.0032 0.0033 0.0114
Toxoplasma gondii cathepsin B 0.0045 0.0061 0.2469
Brugia malayi hypothetical protein 0.0083 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Brugia malayi MH2 domain containing protein 0.0138 0.0272 0.0271
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0054 0.0186
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0014 0.0024
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.032 0.0683 0.2387
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0011 0.0018
Echinococcus multilocularis hypothetical protein 0.002 0.0006 0.0019
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0004
Brugia malayi Muscleblind-like protein 0.0173 0.035 0.0349
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.0102 0.0353
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Schistosoma mansoni nAChR subunit 0.0083 0.0147 0.0258
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0024 0.0014 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0095 0.0328
Giardia lamblia Hypothetical protein 0.0143 0.0283 0.0976
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0049 0.0071 0.0246
Leishmania major guanylate kinase, putative 0.002 0.0005 0.0013
Trypanosoma cruzi trypanothione synthetase 0.0136 0.0268 0.0935
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.018 0.0366 0.128
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0049 0.0071 0.0244
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0028 0.0027
Plasmodium vivax plasmepsin V, putative 0.0022 0.0011 0.0033
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0379 0.0816 1
Loa Loa (eye worm) hypothetical protein 0.0265 0.056 0.0559
Brugia malayi hypothetical protein 0.0097 0.018 0.0179
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0045 0.0526
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0115 0.0219 0.0763
Trypanosoma brucei unspecified product 0.0024 0.0013 0.0043
Schistosoma mansoni memapsin-2 (A01 family) 0.0022 0.0011 0.0018
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.001 0.0034
Loa Loa (eye worm) hypothetical protein 0.032 0.0683 0.0682
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0067
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0028 0.0081
Loa Loa (eye worm) aspartyl protease 6 0.0022 0.0011 0.0009
Brugia malayi polk-prov protein 0.0039 0.0048 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0724 0.2529
Echinococcus granulosus membrane bound transcription factor site 1 0.0018 0.0001 0.0003
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0344 0.0737 0.0736
Brugia malayi hypothetical protein 0.0083 0.0147 0.0146
Brugia malayi calpain 7 0.002 0.0006 0.0005
Echinococcus multilocularis protein dispatched 1 0.0187 0.0384 0.1341
Trypanosoma brucei SIR2-like protein 4, putative 0.0049 0.0071 0.0244
Brugia malayi protein kinase C II. 0.0091 0.0165 0.0164
Loa Loa (eye worm) hypothetical protein 0.0057 0.0089 0.0088
Echinococcus multilocularis dna polymerase eta 0.0034 0.0038 0.013
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Schistosoma mansoni hypothetical protein 0.0047 0.0066 0.0116
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.018 0.0366 0.0365
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0007 0.0021
Giardia lamblia Transcriptional regulator, Sir2 family 0.0049 0.0071 0.0231
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.1282 0.2858 1
Loa Loa (eye worm) POT family protein 0.0041 0.0052 0.0051
Onchocerca volvulus 0.018 0.0366 0.448
Brugia malayi hypothetical protein 0.0273 0.0578 0.0577
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0054 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Plasmodium vivax NAD-dependent deacetylase, putative 0.0049 0.0071 0.0244
Loa Loa (eye worm) LGC-31 protein 0.018 0.0366 0.0365
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0038 0.0036
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.018 0.0366 0.0365
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Brugia malayi hypothetical protein 0.0022 0.0011 0.0009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Trypanosoma brucei guanylate kinase, putative 0.002 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0059 0.0092 0.0091
Brugia malayi NAD-dependent deacetylase SIRT1 0.0265 0.056 0.0559
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0083 0.0147 0.0514
Schistosoma mansoni maguk P55 subfamily member 26 0.002 0.0005 0.0008
Echinococcus multilocularis high voltage activated calcium channel beta 0.002 0.0005 0.0016
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0143 0.0283 0.0987
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0119 0.0411
Trypanosoma brucei calpain-like protein, putative 0.002 0.0006 0.0016
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0379 0.0816 0.2855
Echinococcus granulosus glutamate receptor 2 0.0022 0.001 0.0034
Brugia malayi MAP kinase sur-1 0.006 0.0095 0.0094
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0014 0.0045
Trypanosoma brucei calpain-like protein, putative 0.002 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.0178
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0014 0.0045
Onchocerca volvulus 0.0082 0.0146 0.1783
Echinococcus granulosus dna polymerase eta 0.0034 0.0038 0.013
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Brugia malayi Death domain containing protein 0.003 0.0028 0.0027
Echinococcus granulosus calpain A 0.0056 0.0087 0.0304
Leishmania major guanylate kinase-like protein 0.002 0.0005 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0267 0.0467
Loa Loa (eye worm) hypothetical protein 0.0173 0.035 0.0349
Toxoplasma gondii subtilisin SUB7 0.0018 0.0001 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Schistosoma mansoni neurotransmitter gated ion channel 0.0097 0.0179 0.0313
Schistosoma mansoni hypothetical protein 0.0056 0.0086 0.015
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.0028 0.0097
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.018 0.0366 0.0365
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0179 0.0178
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.004 0.0051 0.0161
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.0051 0.0173
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0006 0.0016
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0017 0.0668
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0161 0.0563
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0014 0.0048
Schistosoma mansoni chromatin regulatory protein sir2 0.0143 0.0283 0.0496
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0143 0.0283 0.0987
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.0344 0.0737 0.0736
Onchocerca volvulus Netrin receptor homolog 0.003 0.0028 0.033
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0014 0.0045
Loa Loa (eye worm) acetylcholine receptor protein 0.0083 0.0147 0.0146
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.015 0.0299 0.1043
Loa Loa (eye worm) hypothetical protein 0.0054 0.0082 0.0081
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0038 0.0036
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0014 0.0048
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0014 0.0048
Loa Loa (eye worm) sirtuin 4 0.0049 0.0071 0.007
Loa Loa (eye worm) prolyl oligopeptidase 0.003 0.0028 0.0027
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0082 0.0081
Echinococcus multilocularis nmda type glutamate receptor 0.0052 0.0078 0.0272
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0025 0.0017 0.0059
Loa Loa (eye worm) hypothetical protein 0.0082 0.0146 0.0145
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0054 0.0183
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0006 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0724 0.2529
Entamoeba histolytica hypothetical protein 0.0036 0.0042 0.0129
Schistosoma mansoni tumor necrosis factor receptor related 0.0046 0.0064 0.0111
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.018 0.0366 0.128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0017 0.0226
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.018 0.0366 0.128
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.018 0.0366 0.0365
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.018 0.0366 0.0365
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0089 0.0156
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0009
Onchocerca volvulus 0.018 0.0366 0.448
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0097 0.0179 0.0178
Echinococcus multilocularis guanylate kinase 0.002 0.0005 0.0016
Echinococcus granulosus glycine receptor subunit alpha 1 0.018 0.0366 0.128
Toxoplasma gondii aspartyl protease ASP1 0.0059 0.0092 0.3727
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0022 0.0011 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0051 0.0173
Loa Loa (eye worm) prolyl oligopeptidase 0.0379 0.0816 0.0815
Plasmodium falciparum plasmepsin V 0.0022 0.0011 0.0033
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0087 0.0304
Echinococcus granulosus high voltage activated calcium channel beta 0.002 0.0005 0.0016
Toxoplasma gondii subtilisin SUB5 0.0018 0.0001 0.0047
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0006 0.0016
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0059 0.0092 0.0322
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0155 0.031 0.1081
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0379 0.0816 0.1429
Echinococcus multilocularis nAChR subunit 0.018 0.0366 0.128
Schistosoma mansoni inositol transporter 0.0323 0.0691 0.121
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Echinococcus granulosus serine:threonine protein kinase N2 0.0074 0.0128 0.0445
Schistosoma mansoni nAChR subunit 0.018 0.0366 0.0641
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0014 0.0045
Echinococcus granulosus high voltage activated calcium channel beta 0.002 0.0005 0.0016
Schistosoma mansoni MAGUK homolog 0.0024 0.0014 0.0024
Echinococcus granulosus prolyl endopeptidase 0.003 0.0028 0.0096
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0014 0.0095
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0017 0.013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0097 0.018 0.0179
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0247 0.0519 0.0908
Echinococcus granulosus geminin 0.0185 0.0379 0.1324
Toxoplasma gondii subtilisin SUB12 0.0018 0.0001 0.0047
Brugia malayi cathepsin B-like cysteine proteinase 0.0136 0.0267 0.0266
Echinococcus multilocularis glycine receptor subunit beta 0.018 0.0366 0.128
Trypanosoma cruzi oligopeptidase b 0.003 0.0028 0.0093
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0014 0.0024
Echinococcus multilocularis protein patched 0.018 0.0368 0.1287
Trypanosoma brucei trypanothione synthetase, putative 0.0136 0.0268 0.0935
Plasmodium falciparum plasmepsin X 0.0101 0.0189 0.0659
Echinococcus multilocularis acylamino acid releasing enzyme 0.003 0.0028 0.0096
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.018 0.0366 0.0365
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0054 0.0186
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0004
Schistosoma mansoni cathepsin D (A01 family) 0.0243 0.051 0.0892
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0006 0.0016
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0045 0.0061 0.021
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0155 0.031 0.1081
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0071 0.0244
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0095 0.0328
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0028 0.0027
Echinococcus multilocularis netrin receptor unc 5 0.003 0.0028 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0028 0.0093
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0022 0.0011 0.0426
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.001 0.0034
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.003 0.0028 0.0093
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.018 0.0366 0.0365
Echinococcus multilocularis glutamate receptor 2 0.0022 0.001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Toxoplasma gondii subtilisin SUB10 0.0018 0.0001 0.0047
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 0.0724 0.2519
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0059 0.0092 0.0319
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0028 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0011 0.0018
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0161 0.0563
Onchocerca volvulus 0.0057 0.0089 0.108
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0185 0.0379 0.0663
Schistosoma mansoni survival motor neuron protein 0.0056 0.0086 0.015
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.0071 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0024 0.0014 0.0048
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.444 1 1
Onchocerca volvulus 0.0056 0.0086 0.104
Onchocerca volvulus 0.0083 0.0147 0.1794
Onchocerca volvulus 0.0097 0.0179 0.218
Loa Loa (eye worm) hypothetical protein 0.0155 0.031 0.0309
Echinococcus granulosus acylamino acid releasing enzyme 0.003 0.0028 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0054 0.0183
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.002 0.0005 0.0004
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0379 0.0816 0.2855
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0014 0.0013
Giardia lamblia Fructose-bisphosphate aldolase 0.0338 0.0724 0.2519
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0087 0.0152
Echinococcus granulosus cpg binding protein 0.0032 0.0033 0.0114
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0049 0.0071 0.0244
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.004 0.0051 0.0173
Trypanosoma cruzi prolyl endopeptidase 0.003 0.0028 0.0093
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0014 0.0048
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.018 0.0366 0.0365
Onchocerca volvulus 0.0034 0.0036 0.0424
Trypanosoma cruzi oligopeptidase b 0.003 0.0028 0.0093
Brugia malayi N-myristoyltransferase 2 0.1282 0.2858 0.2857
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.004 0.0051 0.0176
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0045 0.0526
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0221 0.046 0.1609
Schistosoma mansoni DNA polymerase eta 0.0034 0.0038 0.0065
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Plasmodium vivax aspartyl proteinase, putative 0.0022 0.0011 0.0033
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0046 0.0064 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0054 0.0186
Plasmodium falciparum plasmepsin II 0.0059 0.0092 0.0319
Brugia malayi CHE-14 protein 0.018 0.0368 0.0367
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0083 0.0147 0.0514
Leishmania major silent information regulator 2, putative 0.0143 0.0283 0.0987
Schistosoma mansoni hypothetical protein 0.0047 0.0066 0.0116
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.003 0.0028 0.0048
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.015 0.0299 0.1043
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0097 0.0179 0.0178
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.0038 0.0036
Trypanosoma brucei unspecified product 0.0056 0.0086 0.0297
Echinococcus multilocularis inhibitor of apoptosis protein 0.0217 0.0451 0.1576
Schistosoma mansoni nAChR subunit 0.018 0.0366 0.0641
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0095 0.0331
Loa Loa (eye worm) hypothetical protein 0.0024 0.0014 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0027
Schistosoma mansoni alpha glucosidase 0.0042 0.0054 0.0095
Echinococcus granulosus Furin 1 0.0018 0.0001 0.0003
Onchocerca volvulus 0.004 0.0051 0.0608
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0161 0.0282
Brugia malayi guanylate kinase 0.002 0.0005 0.0004
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0095 0.0328
Giardia lamblia Rab geranylgeranyltransferase 0.0155 0.031 0.107
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0017 1
Brugia malayi prolyl oligopeptidase family protein 0.0127 0.0248 0.0247
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0095 0.0328
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.018 0.0366 0.128
Echinococcus granulosus death domain containing protein 0.003 0.0028 0.0097
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0097 0.0179 0.0313
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0143 0.0283 0.099
Onchocerca volvulus 0.0097 0.0179 0.218
Echinococcus multilocularis muscleblind protein 0.0173 0.035 0.1224
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0217 0.0451 0.1576
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.004 0.0051 0.005
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0028 0.0049
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0007 0.0089
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Echinococcus multilocularis disks large 1 0.002 0.0005 0.0016
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0017 0.0464
Schistosoma mansoni inositol transporter 0.0323 0.0691 0.121
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0046 0.0064 0.0222
Entamoeba histolytica hypothetical protein 0.0036 0.0042 0.0129
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0054 0.0174
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.0047 0.0066 0.0116
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0027
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0069 0.0115 0.0114
Treponema pallidum fructose-bisphosphate aldolase 0.0338 0.0724 1
Schistosoma mansoni acetylcholine receptor-related 0.0083 0.0147 0.0258
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0095 0.0328
Onchocerca volvulus 0.0217 0.0451 0.5516
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0028 0.0093
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0127 0.0248 0.0863
Echinococcus granulosus dna polymerase kappa 0.0063 0.0102 0.0356
Brugia malayi Uncoordinated protein 44 0.003 0.0028 0.0027
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.0038 0.013
Echinococcus granulosus sodium:glucose cotransporter 0.0323 0.0691 0.2417
Onchocerca volvulus 0.0109 0.0206 0.2515
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.018 0.0366 0.128
Schistosoma mansoni hypothetical protein 0.0036 0.0042 0.0072
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0052 0.0078 0.0272
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.018 0.0366 0.128
Echinococcus multilocularis nAChR subunit 0.0097 0.0179 0.0625
Giardia lamblia DINP protein human, muc B family 0.0041 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.0178
Echinococcus granulosus solute carrier family 5 0.0323 0.0691 0.2417
Chlamydia trachomatis outer membrane protein PmpB 0.0172 0.0349 1
Brugia malayi calpain family protein 1 0.0054 0.0082 0.0081
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0591 0.1296 0.2269
Plasmodium vivax calpain, putative 0.002 0.0006 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.018 0.0366 0.0365
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.018 0.0366 0.0365
Echinococcus multilocularis cathepsin b 0.0136 0.0267 0.0932
Trypanosoma brucei amidase, putative 0.0044 0.0059 0.0201
Echinococcus granulosus Protein patched homolog 1 0.018 0.0368 0.1287
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0386 0.1348
Loa Loa (eye worm) hypothetical protein 0.0217 0.0451 0.045
Brugia malayi aspartic protease BmAsp-1, identical 0.0022 0.0011 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.018 0.0366 0.0365
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.018 0.0366 0.0365
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0102 0.1478
Loa Loa (eye worm) hypothetical protein 0.018 0.0368 0.0367
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0006 0.0016
Toxoplasma gondii subtilisin SUB11 0.0018 0.0001 0.0047
Onchocerca volvulus Deterin homolog 0.0217 0.0451 0.5516
Plasmodium vivax hypothetical protein, conserved 0.003 0.0028 0.0093
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0091 0.3663
Loa Loa (eye worm) guanylate kinase 0.002 0.0005 0.0004
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0014 0.0048
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0083 0.0147 0.0146
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0014 0.0158
Brugia malayi excitatory GABA receptor EXP-1A 0.018 0.0366 0.0365
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0119 0.0207
Trypanosoma brucei unspecified product 0.0024 0.0013 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0017 0.0464
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0007 0.0006
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0265 0.056 0.1958
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.2542 0.5709 1
Schistosoma mansoni cpg binding protein 0.0032 0.0033 0.0057
Schistosoma mansoni neurotransmitter gated ion channel 0.0083 0.0147 0.0258
Loa Loa (eye worm) ACC-1 protein 0.018 0.0366 0.0365
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.1282 0.2858 1
Schistosoma mansoni hypothetical protein 0.0217 0.0451 0.0789
Trypanosoma brucei N-myristoyl transferase, putative 0.1282 0.2858 1
Trichomonas vaginalis sap-102, putative 0.002 0.0005 0.0013
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0045 0.0061 0.021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.0092 0.0161
Schistosoma mansoni MAGUK homolog 0.0025 0.0017 0.0029
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0054 0.0189
Echinococcus granulosus high affinity choline transporter 1 0.0082 0.0146 0.0511
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.018 0.0366 0.0365
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.0038 0.0115
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0013 0.0023
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.018 0.0366 0.0365
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0086 0.0297
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0265 0.056 0.1956
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.0082 0.0142
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0127 0.0248 1
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0014 0.0033
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.018 0.0366 0.0365
Echinococcus granulosus tumor protein p63 0.039 0.0843 0.2948
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.003 0.0028 0.0802
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.004 0.0051 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0724 0.2529
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.0578 0.2021
Echinococcus multilocularis sterol regulatory element binding protein 0.018 0.0368 0.1287
Trypanosoma brucei oligopeptidase b 0.003 0.0028 0.0093
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0155 0.031 0.1081
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0059 0.0201
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0018 0.0001 0.0003
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.018 0.0366 0.128
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.0178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.018 0.0366 0.0365
Loa Loa (eye worm) N-myristoyltransferase 2 0.1282 0.2858 0.2857
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0007 0.0021
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0049 0.0071 0.0231
Entamoeba histolytica hypothetical protein 0.0097 0.0179 0.061
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0006 0.0016
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0095 0.0316
Echinococcus granulosus nAChR subunit 0.0097 0.0179 0.0625
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.0178
Loa Loa (eye worm) hypothetical protein 0.0024 0.0014 0.0013
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.001 0.0034
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0127 0.0248 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0368 0.1284
Trypanosoma cruzi N-myristoyl transferase, putative 0.1282 0.2858 1
Trypanosoma brucei antigen, putative 0.002 0.0006 0.0016
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.003 0.0028 0.039
Schistosoma mansoni ankyrin 23/unc44 0.003 0.0028 0.0049
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.018 0.0366 0.0365
Loa Loa (eye worm) hypothetical protein 0.0039 0.0048 0.0047
Schistosoma mansoni chromatin regulatory protein sir2 0.0143 0.0283 0.0496
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.0038 0.013
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0136 0.0267 0.093
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0011 0.0018
Echinococcus granulosus sodium:glucose cotransporter 2 0.0323 0.0691 0.2417
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.0386 0.1348
Trypanosoma cruzi guanylate kinase, putative 0.002 0.0005 0.0013
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0119 0.0414
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0095 0.0094
Mycobacterium ulcerans Sir2-like regulatory protein 0.0049 0.0071 0.102
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0027
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.018 0.0366 0.128
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.0178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.018 0.0366 0.0365
Trypanosoma cruzi N-myristoyl transferase, putative 0.1282 0.2858 1
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0014 0.0045
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Schistosoma mansoni maguk P55 subfamily member 26 0.0024 0.0014 0.0024
Brugia malayi Guanylate kinase family protein 0.002 0.0005 0.0004
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0006 0.0016
Leishmania major protein farnesyltransferase alpha subunit, putative 0.004 0.0051 0.0173
Plasmodium falciparum plasmepsin IX 0.0101 0.0189 0.0659
Schistosoma mansoni nAChR subunit 0.018 0.0366 0.0641
Echinococcus multilocularis muscleblind protein 1 0.0173 0.035 0.1224
Schistosoma mansoni neurotransmitter gated ion channel 0.0083 0.0147 0.0258
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0054 0.0186
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0119 0.4785
Echinococcus granulosus expressed conserved protein 0.0107 0.0202 0.0704
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0006 0.0016
Trichomonas vaginalis N-myristoyl transferase, putative 0.0842 0.1864 0.6521
Schistosoma mansoni N-myristoyltransferase 0.1282 0.2858 0.5006
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0028 0.0027
Trichomonas vaginalis N-myristoyl transferase, putative 0.1282 0.2858 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0074 0.0128 0.0224
Brugia malayi Pepsin A precursor 0.0022 0.0011 0.0009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0006 0.0016
Echinococcus granulosus Ankyrin 0.003 0.0028 0.0097
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0054 0.0174
Echinococcus granulosus disks large 1 0.002 0.0005 0.0016
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0024 0.0014 0.0048
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0049 0.0071 0.0244
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0017 0.0054
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0462 0.1005 0.176
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0119 0.0414
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.018 0.0366 0.0641
Schistosoma mansoni calpain C (C02 family) 0.002 0.0006 0.001
Giardia lamblia Sirtuin type 2 0.0049 0.0071 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0011 0.0018
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.003 0.0028 0.0048
Chlamydia trachomatis outer membrane protein PmpE 0.0172 0.0349 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.001 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0054 0.0186
Onchocerca volvulus 0.018 0.0366 0.448
Echinococcus multilocularis tumor protein p63 0.039 0.0843 0.2948
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0221 0.046 0.1609
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0024 0.0014 0.0048
Echinococcus granulosus guanylate kinase 0.002 0.0005 0.0016
Echinococcus granulosus neuroendocrine convertase 2 0.0018 0.0001 0.0003
Echinococcus multilocularis membrane bound transcription factor site 1 0.0018 0.0001 0.0003
Schistosoma mansoni cpg binding protein 0.0032 0.0033 0.0057
Trypanosoma brucei calpain-like protein, putative 0.002 0.0006 0.0016
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0095 0.383
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.018 0.0366 0.0365
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0014 0.0048
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.032 0.0683 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0323 0.0691 0.2417
Echinococcus granulosus chromatin regulatory protein sir2 0.0143 0.0283 0.099
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.004 0.0051 0.0176
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0102 0.1478
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0265 0.056 0.1958
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0049 0.0071 0.0231
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0165 0.0288
Schistosoma mansoni acetylcholine receptor subunit beta 0.0083 0.0147 0.0258
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.0178
Brugia malayi Protein kinase domain containing protein 0.0031 0.0031 0.003
Loa Loa (eye worm) cathepsin B 0.0045 0.0061 0.006
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0323 0.0691 0.2417
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 0.0724 0.2519
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Echinococcus granulosus sodium:myo inositol cotransporter 0.0323 0.0691 0.2417
Echinococcus multilocularis glycine receptor subunit alpha 1 0.018 0.0366 0.128
Plasmodium falciparum plasmepsin VI 0.0059 0.0092 0.0319
Echinococcus multilocularis chromatin regulatory protein sir2 0.0143 0.0283 0.099
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Loa Loa (eye worm) GABA receptor subunit 0.0097 0.0179 0.0178
Brugia malayi hypothetical protein 0.0083 0.0147 0.0146
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0017 0.0054
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.018 0.0366 0.128
Mycobacterium leprae Probable guanylate kinase Gmk (GMP kinase). 0.002 0.0005 0.0109
Giardia lamblia Cathepsin B precursor 0.0045 0.0061 0.0198
Echinococcus granulosus furin 0.0018 0.0001 0.0003
Onchocerca volvulus 0.018 0.0366 0.448
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.1282 0.2858 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0018 0.0001 0.0001
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0265 0.056 0.1946
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.018 0.0366 0.128
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.003 0.0028 0.0093
Echinococcus granulosus protein prenyltransferase alpha subunit 0.004 0.0051 0.0176
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0127 0.0248 0.0863
Loa Loa (eye worm) calpain 0.002 0.0006 0.0005
Leishmania major DNA polymerase eta, putative 0.0034 0.0038 0.0127
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0155 0.031 0.1084
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0265 0.056 0.1956
Toxoplasma gondii histone deacetylase SIR2 0.0049 0.0071 0.2855
Loa Loa (eye worm) hypothetical protein 0.0173 0.035 0.0349
Trypanosoma cruzi trypanothione synthetase 0.0136 0.0268 0.0935
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0007 0.0184
Trypanosoma brucei trypanothione synthetase 0.0136 0.0268 0.0935
Echinococcus multilocularis dna polymerase kappa 0.0063 0.0102 0.0356
Plasmodium falciparum plasmepsin IV 0.0059 0.0092 0.0319
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.003 0.0028 0.1121
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.003 0.0028 0.0093
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0217 0.0451 0.045
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0095 0.0328
Trypanosoma brucei guanylate kinase, putative 0.002 0.0005 0.0013
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.002 0.0005 0.0008
Schistosoma mansoni nAChR subunit 0.018 0.0366 0.0641
Schistosoma mansoni alpha-glucosidase 0.0162 0.0326 0.0571
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0051 0.0173
Echinococcus multilocularis 0.0024 0.0014 0.0048
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Brugia malayi Cation transporter family protein 0.018 0.0366 0.0365
Schistosoma mansoni furin-1 (S08 family) 0.0018 0.0001 0.0001
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0017 0.0668
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0007 0.2096
Brugia malayi Guanylate kinase family protein 0.008 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0009
Schistosoma mansoni ap endonuclease 0.0021 0.0007 0.0012
Echinococcus multilocularis expressed conserved protein 0.0107 0.0202 0.0704
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0054 0.0053
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.018 0.0366 0.0365
Schistosoma mansoni patched 1 0.018 0.0368 0.0644
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0014 0.0048
Brugia malayi Guanylate kinase family protein 0.0024 0.0014 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0042 0.0072
Entamoeba histolytica dipeptidyl-peptidase, putative 0.003 0.0028 0.0081
Echinococcus multilocularis calpain 0.002 0.0006 0.0019
Echinococcus granulosus disks large 3 0.0073 0.0124 0.0433
Brugia malayi ZU5 domain containing protein 0.002 0.0005 0.0004
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0051 0.0173
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0155 0.031 0.1081
Echinococcus granulosus nmda type glutamate receptor 0.0052 0.0078 0.0272
Echinococcus multilocularis guanylate kinase 0.002 0.0005 0.0016
Echinococcus multilocularis calpain 5 0.0022 0.0009 0.003
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0014 0.0045
Onchocerca volvulus 0.018 0.0366 0.448
Brugia malayi hypothetical protein 0.0022 0.0011 0.0009
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0024 0.0014 0.0013
Trichomonas vaginalis calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative 0.002 0.0005 0.0013
Schistosoma mansoni nAChR subunit 0.018 0.0366 0.0641
Trichomonas vaginalis discs large, putative 0.002 0.0005 0.0013
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.018 0.0366 0.0641
Echinococcus multilocularis cathepsin b 0.0136 0.0267 0.0932
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0136 0.0267 0.0467
Schistosoma mansoni site-1 peptidase (S08 family) 0.0018 0.0001 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0294 0.0625 0.2187
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0049 0.0071 0.2097
Onchocerca volvulus 0.0083 0.0147 0.1794
Toxoplasma gondii subtilisin SUB1 0.0018 0.0001 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0061 0.021
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.018 0.0366 0.128
Onchocerca volvulus 0.0083 0.0147 0.1794
Schistosoma mansoni alpha-glucosidase 0.0162 0.0326 0.0571
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0028 0.0093
Schistosoma mansoni hypothetical protein 0.0435 0.0944 0.1652
Loa Loa (eye worm) subtilase 0.0591 0.1296 0.1295
Chlamydia trachomatis outer membrane protein PmpC 0.0172 0.0349 1
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0217 0.0451 0.1576
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.018 0.0366 0.128
Loa Loa (eye worm) hypothetical protein 0.0082 0.0146 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0095 0.0166
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0127 0.0248 0.0863
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Plasmodium falciparum plasmepsin I 0.0059 0.0092 0.0319
Onchocerca volvulus 0.0031 0.0029 0.0341
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.002 0.0005 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0119 0.1722
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.015 0.0299 0.1043
Echinococcus multilocularis glycine receptor subunit alpha 1 0.018 0.0366 0.128
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0014 0.0045
Toxoplasma gondii aspartyl protease ASP3 0.0101 0.0189 0.7643
Entamoeba histolytica hypothetical protein 0.0036 0.0042 0.0129
Echinococcus granulosus glycine receptor subunit alpha 1 0.018 0.0366 0.128
Toxoplasma gondii hypothetical protein 0.003 0.0028 0.1121
Schistosoma mansoni maguk P55 subfamily member 35 0.0024 0.0014 0.0024
Echinococcus granulosus muscleblind protein 0.0173 0.035 0.1224
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0054 0.0186
Schistosoma mansoni cpg binding protein 0.0031 0.0029 0.005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0006 0.0016
Loa Loa (eye worm) guanylate kinase 0.006 0.0096 0.0095
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Loa Loa (eye worm) hypothetical protein 0.0136 0.0267 0.0266
Echinococcus multilocularis disks large 3 0.0073 0.0124 0.0433
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0059 0.0092 0.0322
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.018 0.0366 0.0365
Leishmania major hypothetical protein, conserved 0.0044 0.0059 0.0201
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0071 0.0123
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Brugia malayi hypothetical protein 0.0083 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.0178
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0007 0.0021
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0217 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0054 0.0186
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0011 0.0018
Onchocerca volvulus 0.0022 0.0011 0.0115
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.0038 0.0127
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0095 0.0328
Schistosoma mansoni hypothetical protein 0.003 0.0028 0.0049
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0071 0.0244
Loa Loa (eye worm) transcriptional regulator 0.0049 0.0071 0.007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0095 0.0328
Loa Loa (eye worm) hypothetical protein 0.006 0.0095 0.0094
Echinococcus multilocularis protein kinase c epsilon type 0.0091 0.0165 0.0576
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0217 0.0759
Echinococcus multilocularis neuroendocrine convertase 2 0.0018 0.0001 0.0003
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0083 0.0147 0.0146
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0028 0.0081
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0054 0.1579
Loa Loa (eye worm) hypothetical protein 0.0489 0.1067 0.1066
Schistosoma mansoni hypothetical protein 0.0185 0.0379 0.0663
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.018 0.0366 0.128
Schistosoma mansoni nAChR subunit 0.0083 0.0147 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0029 0.0099
Plasmodium falciparum plasmepsin III 0.0022 0.0011 0.0033
Schistosoma mansoni guanylate kinase 0.002 0.0005 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0102 0.0353
Loa Loa (eye worm) hypothetical protein 0.004 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0034 0.0036 0.0035
Schistosoma mansoni site-1 peptidase (S08 family) 0.0018 0.0001 0.0001
Plasmodium falciparum peptidase, putative 0.003 0.0028 0.0093
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.1282 0.2858 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0127 0.0248 0.0866
Echinococcus granulosus calpain 5 0.0022 0.0009 0.003
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0083 0.0147 0.0514
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0071 0.0123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0724 0.2529
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0709 0.1564 0.547
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0006 0.0016
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0082 0.0146 0.0511
Echinococcus multilocularis geminin 0.0185 0.0379 0.1324
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0011 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0265 0.056 0.1956
Trypanosoma brucei prolyl endopeptidase 0.003 0.0028 0.0093
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0143 0.0283 0.0987
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0014 0.0048
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.015 0.0299 0.1032
Plasmodium vivax aspartyl protease, putative 0.0101 0.0189 0.0659
Schistosoma mansoni inhibitor of apoptosis protein 0.0217 0.0451 0.0789
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0014 0.0048
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.004 0.0051 0.0173
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0007 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0119 0.1722
Echinococcus multilocularis calpain A 0.0056 0.0087 0.0304
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0102 0.0353
Mycobacterium tuberculosis Probable peptidase 0.003 0.0028 0.0802
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0265 0.056 0.1956
Echinococcus granulosus glycine receptor subunit beta 0.018 0.0366 0.128
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0045 0.0642
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0054 0.0186
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0007 0.0021
Mycobacterium tuberculosis Probable guanylate kinase Gmk 0.002 0.0005 0.0109
Toxoplasma gondii subtilisin SUB4 0.0018 0.0001 0.0047
Entamoeba histolytica hypothetical protein, conserved 0.003 0.0028 0.0081
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0083 0.0147 0.0146
Schistosoma mansoni ATP-dependent RNA Helicase 0.0024 0.0014 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0147 0.0146
Giardia lamblia Alanyl dipeptidyl peptidase 0.003 0.0028 0.0081
Brugia malayi abnormal cell lineage protein 2 0.002 0.0005 0.0004
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.0051 0.0173
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0006 0.0016
Brugia malayi POT family protein 0.0041 0.0052 0.0051
Echinococcus multilocularis Niemann Pick C1 protein 0.0294 0.0625 0.2187
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0143 0.0283 0.0976
Toxoplasma gondii histone deacetylase SIR2-like 0.0049 0.0071 0.2855
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0165
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0179 0.0178
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0007 0.0009
Toxoplasma gondii guanylate kinase family protein 0.002 0.0005 0.0194
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.0333 1
Echinococcus granulosus netrin receptor unc 5 0.003 0.0028 0.0097
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.018 0.0366 0.0641
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.001 0.0034
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0217 0.0451 0.045
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0044 0.0059 0.0201
Mycobacterium ulcerans NAD-dependent deacetylase 0.0049 0.0071 0.102
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.001 0.0034
Echinococcus granulosus cathepsin b 0.0136 0.0267 0.0932
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0017 0.0054
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0011 0.0018
Brugia malayi calpain family protein 1 0.0054 0.0082 0.0081
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0007 0.0009
Toxoplasma gondii subtilisin SUB2 0.0018 0.0001 0.0047
Toxoplasma gondii subtilisin SUB6 0.0018 0.0001 0.0047
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.003 0.0028 0.0048
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.003 0.0028 0.0802
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0007 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0724 0.2529
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0017 0.0054
Schistosoma mansoni calpain (C02 family) 0.002 0.0006 0.001
Trypanosoma brucei cysteine peptidase C (CPC) 0.0045 0.0061 0.021
Plasmodium falciparum guanylate kinase 0.002 0.0005 0.0013
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.0102 0.0353
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0217 0.0451 0.0789
Brugia malayi hypothetical protein 0.0036 0.0042 0.004
Chlamydia trachomatis outer membrane protein PmpF 0.0172 0.0349 1
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.032 0.0683 0.2387
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0143 0.0283 0.0987
Echinococcus multilocularis 0.0018 0.0001 0.0003
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.032 0.0683 0.2387
Echinococcus granulosus protein kinase c epsilon type 0.0091 0.0165 0.0576
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0267 0.0467
Trichomonas vaginalis guanylate kinase, putative 0.002 0.0005 0.0013
Echinococcus granulosus guanylate kinase 0.002 0.0005 0.0016
Toxoplasma gondii aspartyl protease 0.0022 0.0011 0.0426
Trypanosoma brucei glutathionylspermidine synthetase, putative 0.0044 0.0059 0.0201
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0014 0.0045
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.1282 0.2858 1
Onchocerca volvulus 0.0022 0.0011 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0102 0.0353
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0106 0.0186
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.003 0.0028 0.0093
Brugia malayi prolyl oligopeptidase family protein 0.0379 0.0816 0.0815
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0082 0.0146 0.0511
Toxoplasma gondii hypothetical protein 0.0115 0.0219 0.8849
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.001 0.0034
Mycobacterium ulcerans guanylate kinase 0.002 0.0005 0.0053
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.018 0.0366 0.128
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0143 0.0283 0.0976
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0045 0.1167
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.003 0.0028 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0724 0.2529
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0049 0.0071 0.0246
Brugia malayi transcriptional regulator, Sir2 family protein 0.0143 0.0283 0.0282
Leishmania major trypanothione synthetase-like protein 0.0044 0.0059 0.0201
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0143 0.0283 0.0987
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0095 0.0331
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0017 0.0342
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0143 0.0283 0.099
Loa Loa (eye worm) hypothetical protein 0.0089 0.0161 0.016
Echinococcus granulosus inhibitor of apoptosis protein 0.0217 0.0451 0.1576
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0217 0.0744
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0147 0.0146
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.001 0.0017
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0049 0.0071 0.0244
Leishmania major oligopeptidase b 0.003 0.0028 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0724 0.2529
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0029 0.0099
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0006 0.0016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0147 0.0146
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.0038 0.0065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0937 0.2079 0.7273
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0038 0.1097
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0127 0.0248 0.0863
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0028 0.0027
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.004 0.0051 0.0173
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0017 0.0226
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Plasmodium vivax aspartyl protease, putative 0.0101 0.0189 0.0659
Echinococcus multilocularis solute carrier family 5 0.0323 0.0691 0.2417
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0217 0.0759
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0006 0.0016
Plasmodium vivax plasmepsin IV, putative 0.0059 0.0092 0.0319
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0029 0.0028
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0018 0.0001 0.0003
Brugia malayi Peripheral plasma membrane protein CASK 0.0031 0.0031 0.003
Giardia lamblia Cathepsin B precursor 0.0045 0.0061 0.0198
Chlamydia trachomatis glutamine binding protein 0.0038 0.0045 0.1167
Trypanosoma brucei CHAP domain containing protein, putative 0.0044 0.0059 0.0201
Echinococcus granulosus calpain A 0.002 0.0006 0.0019
Onchocerca volvulus Putative nachr subunit 0.018 0.0366 0.448
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0083 0.0147 0.0514
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.018 0.0366 0.0641
Echinococcus granulosus cathepsin b 0.0136 0.0267 0.0932
Echinococcus multilocularis serine:threonine protein kinase N2 0.0083 0.0147 0.0515
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0091 0.0165 0.0164
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0161 0.016
Brugia malayi GH02984p 0.0082 0.0146 0.0145
Trypanosoma cruzi trypanothione synthetase-like protein, putative 0.0044 0.0059 0.0201
Trypanosoma cruzi trypanothione synthetase, putative 0.0044 0.0059 0.0201
Schistosoma mansoni nAChR subunit 0.018 0.0366 0.0641
Schistosoma mansoni cell polarity protein 0.0073 0.0124 0.0217
Loa Loa (eye worm) hypothetical protein 0.0216 0.0449 0.0448
Loa Loa (eye worm) hypothetical protein 0.0261 0.055 0.0549
Echinococcus granulosus Dipeptidyl peptidase 9 0.0127 0.0248 0.0866
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0155 0.031 0.0309
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Chlamydia trachomatis outer membrane protein PmpD 0.0172 0.0349 1
Echinococcus granulosus calpain 7 C02 family 0.002 0.0006 0.0019
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0051 0.0173
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0095 0.0331
Schistosoma mansoni chromatin regulatory protein sir2 0.0143 0.0283 0.0496
Echinococcus granulosus dnaJ subfamily B 0.0435 0.0944 0.3301
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0272 0.0271
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0272 0.0271
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Loa Loa (eye worm) hypothetical protein 0.018 0.0366 0.0365
Entamoeba histolytica hypothetical protein 0.0025 0.0017 0.0041
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.002 0.0005 0.0004
Echinococcus multilocularis glycine receptor subunit beta 0.018 0.0366 0.128
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0155 0.031 0.1084
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0049 0.0071 0.0246
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0128 0.043
Loa Loa (eye worm) guanylate kinase 0.0024 0.0014 0.0013
Brugia malayi hypothetical protein 0.002 0.0005 0.0004
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0083 0.0147 0.0146
Brugia malayi hypothetical protein 0.0083 0.0147 0.0146
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0155 0.031 0.0309
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.0028 0.0097
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.001 0.0034
Brugia malayi Cation transporter family protein 0.018 0.0366 0.0365
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.0944 0.3301
Onchocerca volvulus 0.018 0.0366 0.448
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0087 0.0152
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0095 0.0328
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0054 0.0189
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0127 0.0248 0.0863
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0071 0.0244
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0046 0.0064 0.0222
Leishmania major trypanothione synthetase, putative 0.0136 0.0268 0.0935
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.003 0.0028 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0119 0.1722
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0071 0.0123
Entamoeba histolytica dipeptidyl-peptidase, putative 0.003 0.0028 0.0081
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0155 0.031 0.0543
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.018 0.0366 0.128
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.0071 0.0244
Toxoplasma gondii hypothetical protein 0.004 0.0051 0.2046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0267 0.0467
Brugia malayi Eukaryotic aspartyl protease family protein 0.0022 0.0011 0.0009
Trypanosoma brucei glucosidase, putative 0.0042 0.0054 0.0186
Schistosoma mansoni netrin receptor unc5 0.003 0.0028 0.0049
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.0071 0.007
Trypanosoma brucei N-myristoyltransferase 0.1282 0.2858 1
Echinococcus granulosus sterol regulatory element binding protein 0.018 0.0368 0.1287
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0025 0.0017 0.0059
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0051 0.0173
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0155 0.031 0.1081
Schistosoma mansoni sodium/solute symporter 0.0082 0.0146 0.0256
Entamoeba histolytica hypothetical protein 0.0036 0.0042 0.0129
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0071 0.0244
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0028 0.0027
Giardia lamblia Cathepsin B precursor 0.0045 0.0061 0.0198
Schistosoma mansoni chromatin regulatory protein sir2 0.0265 0.056 0.098
Leishmania major sir2-family protein-like protein 0.0049 0.0071 0.0244
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.018 0.0366 0.0641
Schistosoma mansoni cathepsin D (A01 family) 0.0243 0.051 0.0892
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0386 0.1348
Onchocerca volvulus Prolyl endopeptidase homolog 0.003 0.0028 0.0327
Plasmodium falciparum plasmepsin VIII, putative 0.0022 0.0011 0.0033
Loa Loa (eye worm) transcriptional regulator 0.0143 0.0283 0.0282
Toxoplasma gondii prolyl endopeptidase 0.003 0.0028 0.1121
Echinococcus granulosus glycine receptor subunit alpha 1 0.018 0.0366 0.128
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0119 0.0207
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0042 0.0144
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0011 0.0018
Echinococcus granulosus nAChR subunit 0.018 0.0366 0.128
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0027
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0054 0.2195
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0059 0.0092 0.3727
Brugia malayi Subtilase family protein 0.0591 0.1296 0.1295
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0042 0.0144
Schistosoma mansoni high-affinity choline transporter 0.0082 0.0146 0.0256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0724 0.2529
Echinococcus granulosus calpain 0.002 0.0006 0.0019
Trypanosoma brucei calpain-like protein, putative 0.002 0.0006 0.0016
Echinococcus multilocularis glycine receptor subunit alpha 1 0.018 0.0366 0.128
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0046 0.0064 0.0222
Loa Loa (eye worm) hypothetical protein 0.0217 0.0451 0.045
Schistosoma mansoni ap endonuclease 0.0021 0.0007 0.0012
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0054 0.0186
Leishmania major trypanothione synthetase, putative 0.0044 0.0059 0.0201
Leishmania major N-myristoyl transferase, putative 0.1282 0.2858 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0097 0.0179 0.0313
Schistosoma mansoni nAChR subunit 0.018 0.0366 0.0641
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.032 0.0683 0.2389
Loa Loa (eye worm) hypothetical protein 0.0114 0.0217 0.0216
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.004 0.0051 0.0173
Echinococcus multilocularis high affinity choline transporter 1 0.0082 0.0146 0.0511
Plasmodium vivax aspartyl proteinase, putative 0.0059 0.0092 0.0319
Toxoplasma gondii subtilisin SUB8 0.0018 0.0001 0.0047
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.003 0.0028 0.0093
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0071 0.0244
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.018 0.0368 0.0367
Schistosoma mansoni hypothetical protein 0.0047 0.0066 0.0116
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0007 0.0021
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0045 0.132
Loa Loa (eye worm) hypothetical protein 0.0273 0.0578 0.0577
Brugia malayi CXXC zinc finger family protein 0.0031 0.0029 0.0028
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0014 0.0033
Loa Loa (eye worm) ACC-1 protein 0.018 0.0366 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0165
Loa Loa (eye worm) hypothetical protein 0.0083 0.0147 0.0146
Plasmodium vivax aspartyl protease, putative 0.0022 0.0011 0.0033
Onchocerca volvulus 0.0089 0.0161 0.1965
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0083 0.0147 0.0514
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0071 0.0231
Brugia malayi aspartic protease BmAsp-2, identical 0.0022 0.0011 0.0009
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0049 0.0071 0.0246
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.032 0.0683 0.0682

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2 mg kg-1 Dose causing 50% inhibition of writhing in mouse (PBQ writhing test) ChEMBL. 3373493

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.