Detailed information for compound 1783246

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.349 | Formula: C18H19NO2
  • H donors: 1 H acceptors: 1 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1)ccc(c2)OCCCc1ccccc1
  • InChi: 1S/C18H19NO2/c20-18-11-8-15-13-16(9-10-17(15)19-18)21-12-4-7-14-5-2-1-3-6-14/h1-3,5-6,9-10,13H,4,7-8,11-12H2,(H,19,20)
  • InChiKey: OWCOIDFFIHFSGK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoamine oxidase B Starlite/ChEMBL References
Homo sapiens monoamine oxidase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi amine oxidase, flavin-containing family protein monoamine oxidase B 520 aa 462 aa 19.7 %
Brugia malayi amine oxidase, flavin-containing family protein monoamine oxidase A 527 aa 474 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis snurportin 1 0.0297 0.1158 0.1155
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0095 0.0329 0.1488
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0276 0.1165
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0311
Brugia malayi beta-lactamase 0.0035 0.0082 0.0372
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0003 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.009 0.0087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0109 0.0384 0.0382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0043 0.0128
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0083 0.0276 0.1165
Loa Loa (eye worm) hypothetical protein 0.0118 0.0423 0.042
Schistosoma mansoni alkaline phosphatase 0.0159 0.059 0.059
Schistosoma mansoni hypothetical protein 0.0297 0.1158 0.1158
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0037 0.0035
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0138 0.0138
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0036 0.0155
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0138 0.0135
Mycobacterium ulcerans monoamine oxidase 0.0051 0.0144 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0103 0.0472
Brugia malayi conserved hypotetical protein 0.0019 0.0015 0.0059
Loa Loa (eye worm) hypothetical protein 0.0095 0.0329 0.0326
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0051 0.0208
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0257 0.0254
Brugia malayi nuclear hormone receptor 0.004 0.0103 0.0472
Schistosoma mansoni nuclear receptor 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0135 0.049 0.0488
Loa Loa (eye worm) hypothetical protein 0.0166 0.062 0.0618
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0058 0.0774
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0717 0.2881 0.2879
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0177 0.0741
Leishmania major hypothetical protein, conserved 0.0095 0.0329 0.1392
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0036 0.0531
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0051 0.0144 0.0144
Leishmania major DNA polymerase kappa, putative 0.0016 0.0003 0.0002
Giardia lamblia Phosphoglycerate kinase 0.0166 0.062 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0081 0.0079
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0003 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.0135
Echinococcus multilocularis sphingosine kinase 1 0.2451 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0082 0.0082
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.062 0.2633
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0343
Leishmania major importin beta-1 subunit, putative 0.0023 0.003 0.0115
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0015 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.086 0.0858
Echinococcus granulosus Diacylglycerol kinase zeta 0.0095 0.0329 0.0326
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0202 0.0199
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0015 0.0012
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0006 0.0003
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0188 0.0789
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0034 0.0134
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0138 0.0135
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0015 0.0012
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0058 0.0649
Echinococcus multilocularis Diacylglycerol kinase theta 0.0095 0.0329 0.0326
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0025 0.0025
Trypanosoma cruzi diacylglycerol kinase, putative 0.0095 0.0329 0.1392
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0384 0.0384
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0009 0.0009
Schistosoma mansoni bromodomain containing protein 0.0072 0.0232 0.0232
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0058 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0103 0.0991
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.01
Echinococcus granulosus phosphoglycerate kinase 1 0.0166 0.062 0.0618
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0066 0.1024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0136 0.0136
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0165 0.0165
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.009 0.0087
Mycobacterium leprae Probable lipase LipE 0.0035 0.0082 0.0786
Schistosoma mansoni hypothetical protein 0.0172 0.0642 0.0642
Trichomonas vaginalis heat shock protein, putative 0.0025 0.004 0.0112
Echinococcus multilocularis dna polymerase kappa 0.0078 0.0257 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0136 0.0133
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0199
Schistosoma mansoni terminal deoxycytidyl transferase 0.0052 0.015 0.015
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0202 0.0202
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0043 0.004
Brugia malayi Phosphoglycerate kinase 0.0166 0.062 0.2918
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0202 0.0199
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0188 0.0789
Echinococcus multilocularis 0.0051 0.0144 0.0142
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0036 0.0036
Trypanosoma cruzi diacylglycerol kinase, putative 0.0095 0.0329 0.1392
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0219 0.0219
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0103 0.01
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0067 0.0067
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0543 0.054
Treponema pallidum phosphoglycerate kinase 0.0166 0.062 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.0257 0.1145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.009 0.037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0114 0.0405 0.0402
Schistosoma mansoni ferritin 0.0026 0.0043 0.0043
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.062 0.2873
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0199
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0015 0.0059
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.1158 0.1155
Mycobacterium ulcerans glutaminase 0.0531 0.2118 0.2116
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0543 0.0543
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0036 0.0386
Plasmodium vivax JmjC domain containing protein 0.0016 0.0003 0.0004
Leishmania major diacylglycerol kinase, putative 0.0095 0.0329 0.1392
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0138 0.0135
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0587 0.2347 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0384 0.1751
Brugia malayi ecdysone receptor 0.0019 0.0015 0.0059
Loa Loa (eye worm) DR-78 0.0019 0.0015 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0086 0.0084
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0384 0.0382
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0119 0.055
Brugia malayi nuclear receptor NHR-88 0.004 0.0103 0.0472
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0109 0.0384 0.0382
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0051 0.0144 0.2329
Schistosoma mansoni ferritin light chain 0.0026 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0083 0.0276 0.0276
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.009 0.086
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.2674 0.2674
Trichomonas vaginalis heat shock protein, putative 0.0025 0.004 0.0112
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0101 0.035 0.1481
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0022
Brugia malayi Smad1 0.0016 0.0003 0.0002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.009 0.037
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0147
Onchocerca volvulus Ceramide kinase 1 homolog 0.0095 0.0329 0.3555
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.006 0.0929
Schistosoma mansoni apoferritin-2 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0118 0.0423 0.042
Echinococcus granulosus heat shock protein 90 0.0025 0.004 0.0037
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0177 0.0741
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.009 0.0349
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0122 0.1931
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0043 0.0128
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Echinococcus granulosus ceramide kinase 0.0095 0.0329 0.0326
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0202 0.0202
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0036 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0103 0.01
Echinococcus multilocularis dnaJ subfamily B 0.1624 0.6603 0.6602
Plasmodium falciparum protoporphyrinogen oxidase 0.0051 0.0144 0.2329
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0144 0.2295
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0119 0.049
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0082 0.0079
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0188 0.0789
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0127 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0008
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0051 0.0144 0.0141
Schistosoma mansoni heat shock protein 0.0031 0.0066 0.0066
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0095 0.0329 0.0329
Plasmodium falciparum heat shock protein 90 0.0031 0.0066 0.1065
Trypanosoma brucei diacylglycerol kinase, putative 0.0095 0.0329 0.1392
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0103 0.0472
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.015 0.0696
Brugia malayi diacylglycerol kinase 0.0095 0.0329 0.1542
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0103 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0036 0.0033
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0159 0.059 0.0587
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0015 0.0012
Brugia malayi nuclear receptor RXR 0.0019 0.0015 0.0059
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0384 0.0382
Echinococcus multilocularis neuropeptide s receptor 0.0915 0.3695 0.3694
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0068 0.0278
Echinococcus multilocularis geminin 0.0172 0.0642 0.0639
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0001
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0138 0.0135
Trypanosoma cruzi UDP-galactopyranose mutase 0.0051 0.0144 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.011 0.0459
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0058 0.0649
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0103 0.0103
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0066 0.027
Brugia malayi latrophilin 2 splice variant baaae 0.0235 0.0903 0.4257
Loa Loa (eye worm) hypothetical protein 0.0077 0.0252 0.025
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0003 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0036 0.014
Schistosoma mansoni importin beta-1 0.0028 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Schistosoma mansoni thyroid hormone receptor 0.004 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0109 0.0384 0.0384
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0058 0.0058
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0036 0.014
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.01
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0103 0.0472
Entamoeba histolytica phosphoglycerate kinase, putative 0.0166 0.062 0.062
Trypanosoma brucei heat shock protein, putative 0.0031 0.0066 0.027
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.009 0.037
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0051 0.0144 0.2329
Echinococcus multilocularis alkaline phosphatase 0.0159 0.059 0.0587
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0036 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0036 0.0032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0015 0.0012
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0012 0.0009
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0003 0.0003
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0006 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0103 0.01
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0122 0.0503
Brugia malayi MH2 domain containing protein 0.0236 0.0907 0.4274
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0082 0.0079
Mycobacterium ulcerans hypothetical protein 0.0309 0.1206 0.1204
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0082 0.0336
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0036 0.0033
Entamoeba histolytica deoxycytidyl transferase, putative 0.0052 0.015 0.015
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0021 0.0217
Plasmodium vivax importin-beta 2, putative 0.0028 0.0051 0.0788
Loa Loa (eye worm) hypothetical protein 0.0235 0.0903 0.0901
Loa Loa (eye worm) hypothetical protein 0.0109 0.0384 0.0382
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0003 0.0003
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0058 0.0774
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0103 0.0472
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0036 0.014
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0105 0.1208
Trypanosoma brucei heat shock protein, putative 0.0031 0.0066 0.027
Brugia malayi glutaminase DH11.1 0.0531 0.2118 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0003 0.0003
Echinococcus granulosus transcription factor Dp 1 0.0037 0.009 0.0088
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0015 0.0012
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0066 0.027
Brugia malayi hypothetical protein 0.0019 0.0015 0.0059
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0015 0.0012
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0058 0.0934
Loa Loa (eye worm) diacylglycerol kinase 2 0.0095 0.0329 0.0326
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0252 0.1179
Schistosoma mansoni hypothetical protein 0.0072 0.0233 0.0233
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0081 0.0079
Echinococcus granulosus expressed protein 0.0026 0.0043 0.004
Echinococcus multilocularis heat shock protein 90 0.0025 0.004 0.0037
Brugia malayi hypothetical protein 0.0051 0.0144 0.067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0144 0.0142
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0095 0.0329 0.1392
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0136 0.0133
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0012 0.0197
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.009 0.0411
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.01
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0057 0.0173 0.2003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0103 0.01
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0103 0.01
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0252 0.1064
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.009 0.0349
Echinococcus granulosus neuropeptide receptor A26 0.0915 0.3695 0.3694
Schistosoma mansoni ran 0.0021 0.0021 0.0021
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0036 0.0525
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0103 0.0103
Plasmodium falciparum diacylglycerol kinase, putative 0.0095 0.0329 0.5306
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0003 0.0002
Entamoeba histolytica Ran family GTPase 0.0021 0.0021 0.0021
Brugia malayi hypothetical protein 0.0021 0.0025 0.0103
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0184 0.0182
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0022
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.009 0.1446
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.01
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0233 0.023
Brugia malayi tailless protein 0.0019 0.0015 0.0059
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0051 0.0144 0.2295
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0095 0.0329 0.384
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0021 0.0079
Trichomonas vaginalis diacylglycerol kinase, putative 0.0095 0.0329 0.1488
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0587 0.2347 1
Schistosoma mansoni rotamase 0.0033 0.0071 0.0071
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0311
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0082 0.0336
Onchocerca volvulus Huntingtin homolog 0.0118 0.0423 0.4619
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0066 0.0063
Onchocerca volvulus 0.0024 0.0036 0.0232
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0095 0.0329 0.1488
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0036 0.0155
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0021 0.0018
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.0257 0.1145
Echinococcus multilocularis dna polymerase eta 0.0077 0.0252 0.025
Schistosoma mansoni smad 0.0016 0.0003 0.0003
Trichomonas vaginalis rotamase, putative 0.0032 0.0068 0.0246
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0219 0.0219
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0015 0.0012
Echinococcus granulosus bloom syndrome protein 0.0044 0.0119 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0004
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0011 0.0129
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.0658
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0188 0.0789
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.004 0.0037
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0138 0.0135
Onchocerca volvulus 0.0114 0.0405 0.4417
Echinococcus granulosus heat shock protein 0.0031 0.0066 0.0063
Schistosoma mansoni sphingosine kinase A B 0.2451 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0184 0.0182
Plasmodium falciparum diacylglycerol kinase, putative 0.0095 0.0329 0.5306
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0058 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0086 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0103 0.0472
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0054 0.0051
Schistosoma mansoni hypothetical protein 0.0304 0.1187 0.1187
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0003 0.0002
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0082 0.0079
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0717 0.2881 0.2879
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0103 0.0472
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0144 0.2295
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.01
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0025 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0067 0.0064
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0103 0.01
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0384 0.0382
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0058 0.0934
Loa Loa (eye worm) hypothetical protein 0.2451 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0252 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.011 0.0457
Schistosoma mansoni Smad4 0.0016 0.0003 0.0003
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0066 0.027
Loa Loa (eye worm) RecQ helicase 0.0044 0.0119 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0103 0.01
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0095 0.0329 0.1488
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0066 0.027
Echinococcus granulosus GPCR family 2 0.0109 0.0384 0.0382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0127 0.0124
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0011 0.0174
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0103 0.0472
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0067 0.0757
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0188 0.0789
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0311
Mycobacterium tuberculosis Diacylglycerol kinase 0.0095 0.0329 0.0326
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0257 0.1084
Loa Loa (eye worm) latrophilin receptor protein 2 0.0109 0.0384 0.0382
Echinococcus granulosus lysine specific histone demethylase 1A 0.0051 0.0144 0.0142
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0103 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Brugia malayi Ceramide kinase 0.0095 0.0329 0.1542
Brugia malayi beta-lactamase family protein 0.0035 0.0082 0.0372
Mycobacterium ulcerans hypothetical protein 0.2451 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0015 0.0059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0103 0.01
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0003 0.0003
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0202 0.085
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0012 0.0045
Mycobacterium ulcerans hypothetical protein 0.0035 0.0082 0.0078
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0758 0.0755
Echinococcus multilocularis GPCR, family 2 0.0109 0.0384 0.0382
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0003 0.0049
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0034 0.0086
Schistosoma mansoni DNA helicase recq5 0.0018 0.0012 0.0012
Trypanosoma cruzi UDP-galactopyranose mutase 0.0051 0.0144 0.0604
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0036 0.0033
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0103 0.01
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.01
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0025 0.0025
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0054 0.0051
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0012 0.0146
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.009 0.1407
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.011 0.0457
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0587 0.2347 1
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0384 0.0384
Brugia malayi CXXC zinc finger family protein 0.0114 0.0405 0.1902
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0036 0.0032
Schistosoma mansoni DNA polymerase eta 0.0077 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0056 0.0165 0.0163
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0082 0.0078
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0758 0.0755
Mycobacterium ulcerans phosphoglycerate kinase 0.0166 0.062 0.0617
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0036 0.0574
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.0907 0.0904
Brugia malayi MH1 domain containing protein 0.0016 0.0003 0.0002
Schistosoma mansoni diacylglycerol kinase theta 0.0095 0.0329 0.0329
Schistosoma mansoni jumonji domain containing protein 0.006 0.0184 0.0184
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0278 0.1078 0.4585
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0095 0.0329 0.1392
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0043 0.0123
Schistosoma mansoni ran 0.0021 0.0021 0.0021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0103 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0136 0.0133
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.01
Trichomonas vaginalis glutaminase, putative 0.0531 0.2118 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Giardia lamblia Grp94/Hsp90 0.0025 0.004 0.0592
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0071 0.0323
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0517 0.0514
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0067 0.0067
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0202 0.0942
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0068 0.0278
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0276 0.1165
Brugia malayi jmjC domain containing protein 0.0069 0.0219 0.102
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0103 0.0991
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0103 0.0472
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0008
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Schistosoma mansoni zinc finger protein 0.0019 0.0015 0.0015
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0051 0.0144 0.0144
Schistosoma mansoni DNA helicase recq1 0.0018 0.0012 0.0012
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0087
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0276 0.1165
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0021 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Possible oxidoreductase 0.0051 0.0144 0.0142
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0066 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.011 0.0459
Trichomonas vaginalis importin beta-1, putative 0.0023 0.003 0.0065
Leishmania major phosphoglycerate kinase B, cytosolic 0.0166 0.062 0.2633
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0066 0.027
Schistosoma mansoni thyroid hormone receptor 0.004 0.0103 0.0103
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0066 0.0744
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0036 0.0036
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0012 0.0009
Brugia malayi Eye-specific diacylglycerol kinase 0.0095 0.0329 0.1542
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0043 0.0128
Schistosoma mansoni apoferritin-2 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0079
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0036 0.0036
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0003 0.0052
Echinococcus granulosus FTZ F1 alpha 0.004 0.0103 0.01
Echinococcus multilocularis cpg binding protein 0.0122 0.044 0.0437
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0036 0.0032
Echinococcus granulosus dna polymerase kappa 0.0078 0.0257 0.0254
Trypanosoma brucei heat shock protein, putative 0.0031 0.0066 0.027
Onchocerca volvulus Huntingtin homolog 0.0118 0.0423 0.4619
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0043 0.0054
Echinococcus multilocularis expressed protein 0.0026 0.0043 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Brugia malayi mbt repeat family protein 0.0049 0.0138 0.0637
Schistosoma mansoni zinc finger protein 0.0029 0.0057 0.0057
Echinococcus granulosus neuropeptide s receptor 0.0915 0.3695 0.3694
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0034 0.0134
Loa Loa (eye worm) hypothetical protein 0.0344 0.1351 0.1348
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.009 0.037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0103 0.0472
Entamoeba histolytica diacylglycerol kinase, putative 0.0095 0.0329 0.0329
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.009 0.0086
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0188 0.0789
Leishmania major UDP-galactopyranose mutase 0.0051 0.0144 0.0604
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Onchocerca volvulus 0.0035 0.0082 0.0752
Onchocerca volvulus 0.0049 0.0138 0.1386
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0103 0.0103
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.009 0.0087
Loa Loa (eye worm) PHD-finger family protein 0.002 0.002 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0103 0.0472
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0095 0.0329 0.0326
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0136 0.0136
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0159 0.059 0.0587
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Echinococcus multilocularis protoporphyrinogen oxidase 0.0051 0.0144 0.0142
Schistosoma mansoni hypothetical protein 0.002 0.002 0.002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0036 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0329 0.1488
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0103 0.01
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Brugia malayi hypothetical protein 0.0095 0.0329 0.1542
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0199
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.004 0.0037
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0015 0.0012
Mycobacterium ulcerans oxidoreductase 0.0051 0.0144 0.0141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0043 0.0128
Brugia malayi Bromodomain containing protein 0.0083 0.0279 0.1307
Onchocerca volvulus 0.0035 0.0082 0.0752
Brugia malayi SWIRM domain containing protein 0.0051 0.0144 0.067
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0082 0.0079
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0015 0.0012
Mycobacterium ulcerans dehydrogenase 0.0051 0.0144 0.0141
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0015 0.0059
Schistosoma mansoni ap endonuclease 0.0037 0.009 0.009
Brugia malayi nuclear receptor NHR-88 0.0019 0.0015 0.0059
Loa Loa (eye worm) acetyltransferase 0.0148 0.0543 0.054
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0003 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0329 0.1392
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0243 0.0934 0.0934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0127 0.0127
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0043 0.004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0109 0.0384 0.0382
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0025 0.0022
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0159 0.059 0.0587
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.004 0.0158
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0011 0.0008
Brugia malayi hypothetical protein 0.0118 0.0423 0.1986
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Brugia malayi Phosphoglycerate kinase 0.0061 0.0188 0.0875
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0012 0.0009
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0058 0.0887
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.01
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0003 0.0002
Trichomonas vaginalis diacylglycerol kinase, putative 0.0095 0.0329 0.1488
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0003 0.0002
Entamoeba histolytica hypothetical protein 0.0072 0.0233 0.0233
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0103 0.0103
Schistosoma mansoni cpg binding protein 0.0122 0.044 0.044
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0384 0.0382
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Schistosoma mansoni ferritin 0.0026 0.0043 0.0043
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0278 0.1078 0.4585
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0034 0.0034
Schistosoma mansoni glutaminase 0.0531 0.2118 0.2118
Echinococcus granulosus heat shock protein 90 0.0031 0.0066 0.0063
Mycobacterium ulcerans hypothetical protein 0.0024 0.0036 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0103 0.0472
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0082 0.0372
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0043 0.004
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0052 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0095 0.0329 0.0326
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0058 0.0055
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0098 0.0098
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0015 0.0015
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0086 0.0084
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0058 0.0055
Trypanosoma brucei heat shock protein, putative 0.0031 0.0066 0.027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0127 0.0127
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.003
Echinococcus granulosus alkaline phosphatase 0.0159 0.059 0.0587
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0066 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0082 0.0336
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Onchocerca volvulus 0.0051 0.0144 0.1464
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0233 0.0233
Trypanosoma brucei heat shock protein, putative 0.0031 0.0066 0.027
Echinococcus granulosus endoplasmin 0.0025 0.004 0.0037
Onchocerca volvulus 0.0035 0.0082 0.0752
Schistosoma mansoni hypothetical protein 0.0235 0.0903 0.0903
Echinococcus granulosus ferritin 0.0026 0.0043 0.004
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0015 0.0059
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0166 0.062 0.7267
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0257 0.0254
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0003 0.0045
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0066 0.1018
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0103 0.0103
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0098 0.1535
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0021 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0103 0.01
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0109 0.0384 0.0382
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0066 0.027
Schistosoma mansoni coup transcription factor 0.004 0.0103 0.0103
Trichomonas vaginalis ferritin, putative 0.0026 0.0043 0.0127
Loa Loa (eye worm) hypothetical protein 0.0051 0.0144 0.0142
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0036 0.0032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0127 0.0586
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0025 0.0103
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0107
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0058 0.0199
Mycobacterium ulcerans beta-lactamase 0.0035 0.0082 0.0078
Echinococcus granulosus snurportin 1 0.0297 0.1158 0.1155
Loa Loa (eye worm) beta-lactamase 0.0035 0.0082 0.0079
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0202 0.085
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.062 0.2633
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0138 0.0138
Brugia malayi nuclear receptor NHR-67 0.0019 0.0015 0.0059
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0036 0.0032
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0052 0.015 0.0147
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0003 0.0003
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0293
Schistosoma mansoni alkaline phosphatase 0.0159 0.059 0.059
Brugia malayi Endoplasmin precursor 0.0031 0.0066 0.0299
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0202 0.085
Trypanosoma brucei hypothetical protein, conserved 0.0095 0.0329 0.1392
Giardia lamblia DINP protein human, muc B family 0.0058 0.0177 0.281
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0015 0.0012
Schistosoma mansoni heat shock protein 0.0031 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0119 0.049
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.003 0.0317
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0199
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0015 0.0012
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0103 0.01
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0051 0.0049
Chlamydia trachomatis protoporphyrinogen oxidase 0.0051 0.0144 0.2194
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0082 0.0079
Echinococcus multilocularis heat shock protein 90 0.0031 0.0066 0.0063
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0159 0.059 0.0587
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0012 0.0111
Brugia malayi amine oxidase, flavin-containing family protein 0.0051 0.0144 0.067
Schistosoma mansoni hypothetical protein 0.0109 0.0384 0.0384
Brugia malayi Pre-SET motif family protein 0.0206 0.0783 0.3686
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0066 0.027
Schistosoma mansoni sphingoid long chain base kinase 0.2451 1 1
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0384 0.0382
Schistosoma mansoni diacylglycerol kinase theta 0.0095 0.0329 0.0329
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0043 0.0128
Leishmania major DNA damage repair protein, putative 0.0016 0.0003 0.0002
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0119 0.0116
Brugia malayi heat shock protein 90 0.0031 0.0066 0.0299
Echinococcus multilocularis heat shock protein 0.0031 0.0066 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0082 0.0311
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0051 0.0208
Leishmania major DNA polymerase eta, putative 0.0041 0.0105 0.0438
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.004 0.0592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0103 0.01
Chlamydia trachomatis phosphoglycerate kinase 0.0166 0.062 1
Loa Loa (eye worm) ceramide kinase 0.0095 0.0329 0.0326
Echinococcus granulosus expressed protein 0.0033 0.0071 0.0068
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0012 0.0045
Echinococcus multilocularis ceramide kinase 0.0095 0.0329 0.0326
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.062 0.062
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0043 0.004
Plasmodium vivax diacylglycerol kinase, putative 0.0095 0.0329 0.5285
Mycobacterium ulcerans lipase LipD 0.0035 0.0082 0.0078
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0015 0.0012
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0219 0.0216
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0543 0.2553
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0036 0.0036
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.003 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0127 0.0127
Mycobacterium ulcerans heat shock protein 90 0.0025 0.004 0.0037
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0095 0.0329 0.1392
Schistosoma mansoni cpg binding protein 0.0122 0.044 0.044
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0103 0.01
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0015 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0103 0.01
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0058 0.0055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0103 0.0103
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0025 0.0022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0218 0.0215
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0384 0.1628
Schistosoma mansoni endoplasmin 0.0031 0.0066 0.0066
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0082 0.0079
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0021 0.0079
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0068 0.0068
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0052 0.015 0.0147
Brugia malayi polk-prov protein 0.0042 0.011 0.0506
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0049
Toxoplasma gondii histone lysine-specific demethylase 0.0051 0.0144 0.1667
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Brugia malayi MH1 domain containing protein 0.0016 0.0003 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0257 0.1084
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0188 0.0789
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0103 0.0103
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0188 0.0789
Trichomonas vaginalis chaperonin, putative 0.0024 0.0036 0.0092
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0184 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0103 0.0472
Mycobacterium tuberculosis Conserved hypothetical protein 0.0052 0.015 0.0147
Entamoeba histolytica diacylglycerol kinase, putative 0.0095 0.0329 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Entamoeba histolytica diacylglycerol kinase, putative 0.0095 0.0329 0.0329
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0066 0.0237
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0384 0.1751
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0036 0.0092
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.009 0.0087
Schistosoma mansoni hypothetical protein 0.0172 0.0642 0.0642
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0082 0.0079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0127 0.0124
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Entamoeba histolytica hypothetical protein 0.0072 0.0233 0.0233
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0109 0.0384 0.1804
Entamoeba histolytica hypothetical protein, conserved 0.2451 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0202 0.085
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0012 0.0111
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0011 0.0008
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0051 0.0144 0.0142
Trichomonas vaginalis bmru protein, putative 0.0095 0.0329 0.1488
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0103 0.0472
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0058 0.0649
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0103 0.01
Leishmania major hypothetical protein, conserved 0.0095 0.0329 0.1392
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0068 0.0278
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0079
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0667 0.2674 0.2672
Brugia malayi mbt repeat family protein 0.0049 0.0138 0.0637
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0097 0.1564
Toxoplasma gondii diacylglycerol kinase, putative 0.0095 0.0329 0.384
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.004 0.0158
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0165 0.0768
Schistosoma mansoni ferritin 0.0026 0.0043 0.0043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0082 0.0082
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0003 0.0003
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0166 0.062 0.7267
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0165 0.0163
Trichomonas vaginalis bmru protein, putative 0.0095 0.0329 0.1488
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.009 0.0088
Echinococcus multilocularis neuropeptide receptor A26 0.0915 0.3695 0.3694
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0384 0.5966
Brugia malayi MH2 domain containing protein 0.0016 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0122 0.1403
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.004 0.0158
Brugia malayi hypothetical protein 0.0019 0.0015 0.0059
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0051 0.0144 0.2295
Schistosoma mansoni hypothetical protein 0.0095 0.0329 0.0329
Schistosoma mansoni endoplasmin 0.0031 0.0066 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.2674 0.2672
Trypanosoma cruzi Sphingosine kinase 0.0095 0.0329 0.1392
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0103 0.0103
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0166 0.062 0.0618
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0079
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0105 0.0438
Schistosoma mansoni amine oxidase 0.0051 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0079
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0165 0.0163
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0001
Echinococcus granulosus dnaJ subfamily B 0.1624 0.6603 0.6602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0022
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Schistosoma mansoni ferritin light chain 0.0026 0.0043 0.0043
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0091 0.0088
Brugia malayi 6-phosphofructokinase 0.0109 0.0384 0.1804
Loa Loa (eye worm) hypothetical protein 0.0051 0.0144 0.0142
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0384 0.1628
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0384 0.0382
Schistosoma mansoni ferritin 0.0026 0.0043 0.0043
Entamoeba histolytica diacylglycerol kinase, putative 0.0095 0.0329 0.0329
Plasmodium falciparum endoplasmin, putative 0.0019 0.0016 0.0261
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0202 0.0199
Brugia malayi nuclear hormone receptor 0.0019 0.0015 0.0059
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0095 0.0329 0.0326
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0069 0.0221 0.0218
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0384 0.5938
Echinococcus granulosus microtubule associated protein 2 0.0667 0.2674 0.2672
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.009 0.086
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Loa Loa (eye worm) hypothetical protein 0.0051 0.0144 0.0142
Trichomonas vaginalis ran, putative 0.0021 0.0021 0.0024
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.062 0.2633
Plasmodium vivax phosphoglycerate kinase, putative 0.0166 0.062 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0058 0.0313
Mycobacterium ulcerans diacylglycerol kinase 0.0095 0.0329 0.0326
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0012 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0082 0.0311
Entamoeba histolytica hypothetical protein 0.0072 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0008
Echinococcus multilocularis zinc finger protein 0.0029 0.0057 0.0054
Leishmania major sphingosine kinase A, B, putative 0.0095 0.0329 0.1392
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0384 0.0384
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0023 0.002
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0081 0.0081
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Loa Loa (eye worm) glutaminase 0.0531 0.2118 0.2116
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0079
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0092 0.0422
Leishmania major phosphoglycerate kinase C, glycosomal 0.0166 0.062 0.2633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0103 0.01
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0043 0.0128
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0898 0.4195
Brugia malayi Latrophilin receptor protein 2 0.0109 0.0384 0.1804
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0384 0.1751
Trypanosoma brucei unspecified product 0.0036 0.0084 0.0346
Onchocerca volvulus 0.0234 0.0898 1
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0066 0.0744
Brugia malayi Importin beta-1 subunit 0.0028 0.0051 0.023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0043 0.0128
Brugia malayi Bromodomain containing protein 0.0041 0.0105 0.0485
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0233 0.023
Loa Loa (eye worm) hypothetical protein 0.0051 0.0144 0.0142
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0068 0.0767
Toxoplasma gondii histone lysine methyltransferase SET1 0.0223 0.0852 1
Trypanosoma brucei unspecified product 0.0036 0.0084 0.0346
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0095 0.0329 0.1392
Schistosoma mansoni hypothetical protein 0.0109 0.0384 0.0384
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0058 0.0058
Trypanosoma brucei heat shock protein, putative 0.0031 0.0066 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0103 0.01
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0122 0.1403
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0025 0.0103
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0384 0.0384
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Plasmodium vivax endoplasmin, putative 0.0031 0.0066 0.1024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0783 0.078
Brugia malayi steroid hormone receptor 0.004 0.0103 0.0472
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.004 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0004
Brugia malayi PHD-finger family protein 0.0034 0.0078 0.0357
Brugia malayi nuclear receptor RXR 0.0021 0.0025 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.0071 0.023 0.0971
Brugia malayi Pre-SET motif family protein 0.0032 0.0067 0.0304
Trichomonas vaginalis heat shock protein, putative 0.0025 0.004 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Loa Loa (eye worm) hypothetical protein 0.0051 0.0144 0.0142
Leishmania major GTP-binding protein, putative 0.0021 0.0021 0.0079
Mycobacterium tuberculosis Conserved protein 0.2451 1 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0036 0.0155
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0138 0.1386
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.011 0.0459
Onchocerca volvulus 0.004 0.0103 0.0991
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0065
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0036 0.0036
Toxoplasma gondii exonuclease III APE 0.0037 0.009 0.1022
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0309 0.1206 0.1204
Brugia malayi Diacylglycerol kinase protein 2 0.0095 0.0329 0.1542
Trypanosoma brucei unspecified product 0.0071 0.023 0.0971
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.009 0.1401
Echinococcus granulosus geminin 0.0172 0.0642 0.0639
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.062 0.2633
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0015 0.0059
Trichomonas vaginalis esterase, putative 0.0035 0.0082 0.0311
Brugia malayi diacylglycerol kinase 0.0095 0.0329 0.1542
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0033
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0095 0.0329 0.0326
Schistosoma mansoni hypothetical protein 0.0109 0.0384 0.0384
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0384 0.0381
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0051 0.0144 0.1861
Plasmodium vivax diacylglycerol kinase, putative 0.0095 0.0329 0.5285
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0006
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.062 0.062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0034 0.0134
Brugia malayi hypothetical protein 0.0072 0.0233 0.1089
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0278 0.1078 0.4585
Schistosoma mansoni nuclear receptor 0.0019 0.0015 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0103 0.01
Onchocerca volvulus 0.0032 0.0067 0.0588
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0219 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.0907 0.0904
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0036 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Echinococcus granulosus zinc finger protein 0.0029 0.0057 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0036 0.0155
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0165 0.0163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0103 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Leishmania major DNA polymerase kappa, putative 0.0058 0.0177 0.0741
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0103 0.01
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0095 0.0329 0.384
Leishmania major mitochondrial DNA polymerase beta 0.0587 0.2347 1
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0036 0.0155
Loa Loa (eye worm) hypothetical protein 0.0095 0.0329 0.0326
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0012 0.0009
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0071 0.0068
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0199
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0166 0.062 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0071 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Brugia malayi phosphofructokinase 0.0109 0.0384 0.1804
Leishmania major diacylglycerol kinase-like protein 0.0095 0.0329 0.1392
Brugia malayi 6-phosphofructokinase 0.0109 0.0384 0.1804
Echinococcus multilocularis phosphoglycerate kinase 1 0.0166 0.062 0.0618
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0043 0.0128
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0384 0.1628
Schistosoma mansoni amine oxidase 0.0051 0.0144 0.0144
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0052 0.015 0.0147
Leishmania major heat shock protein 83-1 0.0031 0.0066 0.027
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0082 0.0786
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0043 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Onchocerca volvulus 0.0095 0.0329 0.3555
Trypanosoma brucei heat shock protein, putative 0.0031 0.0066 0.027
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0103 0.0991
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0103 0.0472
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0079
Toxoplasma gondii ABC1 family protein 0.0035 0.0082 0.0928
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0053 0.005
Schistosoma mansoni nuclear hormone receptor 0.004 0.0103 0.0103
Schistosoma mansoni cpg binding protein 0.0114 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0127 0.0124
Trichomonas vaginalis rotamase, putative 0.0033 0.0071 0.0262
Echinococcus granulosus lysine specific histone demethylase 1A 0.0051 0.0144 0.0142
Plasmodium vivax SET domain protein, putative 0.0032 0.0067 0.1042
Loa Loa (eye worm) hypothetical protein 0.0051 0.0144 0.0142
Echinococcus granulosus intestinal type alkaline phosphatase 0.0159 0.059 0.0587
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0015 0.0012
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0021 0.0299
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0122 0.0503
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0082 0.0079
Brugia malayi jmjC domain containing protein 0.006 0.0184 0.0858
Trypanosoma brucei heat shock protein, putative 0.0031 0.0066 0.027
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0003 0.0002
Brugia malayi beta-lactamase family protein 0.0035 0.0082 0.0372
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0066 0.0066
Echinococcus granulosus dna polymerase eta 0.0077 0.0252 0.025
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0257 0.1084
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0103 0.0103
Echinococcus granulosus Diacylglycerol kinase theta 0.0095 0.0329 0.0326
Leishmania major DNA polymerase eta, putative 0.0077 0.0252 0.1064
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0013 0.0044
Loa Loa (eye worm) MBCTL1 0.0056 0.0165 0.0163
Trypanosoma cruzi Sphingosine kinase 0.0095 0.0329 0.1392
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0003 0.0002
Brugia malayi RNA, U transporter 1 0.0079 0.0262 0.1227
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0051 0.0573
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0065
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0122 0.0119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0127 0.0124
Echinococcus granulosus importin subunit beta 1 0.0028 0.0051 0.0049
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0058 0.0893
Echinococcus multilocularis endoplasmin 0.0025 0.004 0.0037
Plasmodium falciparum phosphoglycerate kinase 0.0166 0.062 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0036 0.014
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.009 0.009
Echinococcus multilocularis expressed protein 0.0033 0.0071 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.0128
Entamoeba histolytica hypothetical protein 0.0072 0.0233 0.0233
Trichomonas vaginalis sphingosine kinase, putative 0.0095 0.0329 0.1488
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0344 0.1351 0.1348
Trichomonas vaginalis helicase, putative 0.0026 0.0043 0.0128
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0082 0.1276
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0015 0.0015
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0095 0.0329 0.0326
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0138 0.0138
Brugia malayi ecdysteroid receptor 0.004 0.0103 0.0472
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0098 0.1578
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0384 0.0384
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0384 0.1751
Loa Loa (eye worm) glutaminase 2 0.0531 0.2118 0.2116
Toxoplasma gondii hypothetical protein 0.0095 0.0326 0.3802
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0103 0.01
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0068 0.0278
Brugia malayi MH2 domain containing protein 0.0016 0.0003 0.0002
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0103 0.01
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0003 0.0003
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0015 0.0059
Brugia malayi hypothetical protein 0.0021 0.0025 0.0103
Trypanosoma brucei Sphingosine kinase 0.0095 0.0329 0.1392
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0344 0.1351 0.6371
Brugia malayi Calcitonin receptor-like protein seb-1 0.0344 0.1351 0.6371
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0095 0.0329 0.0329
Leishmania major hypothetical protein, conserved 0.0016 0.0003 0.0001
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0159 0.059 0.0587
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0079
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0036 0.014
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0035 0.0082 0.0336
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0177 0.0174
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.062 0.2873
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0218 0.0215
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0166 0.062 1
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0003 0.0002
Trichomonas vaginalis sphingosine kinase, putative 0.0095 0.0329 0.1488
Plasmodium falciparum importin beta, putative 0.0028 0.0051 0.083
Schistosoma mansoni ap endonuclease 0.0037 0.009 0.009
Echinococcus granulosus cpg binding protein 0.0122 0.044 0.0437
Loa Loa (eye worm) endoplasmin 0.0031 0.0066 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0103 0.0472
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0082 0.0078
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.1624 0.6603 0.6603
Echinococcus multilocularis ferritin 0.0026 0.0043 0.004

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.284 uM Inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry ChEMBL. 24012182
IC50 (binding) = 19.7 uM Inhibition of recombinant human MAO-A assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry ChEMBL. 24012182

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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