Detailed information for compound 1851493

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 616.301 | Formula: C25H29Cl6N3S
  • H donors: 1 H acceptors: 1 LogP: 10.23 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: ClCCN(c1ccc(cc1)SCCNc1c2ccccc2nc2c1cccc2)CCCl.Cl.Cl.Cl.Cl
  • InChi: 1S/C25H25Cl2N3S.4ClH/c26-13-16-30(17-14-27)19-9-11-20(12-10-19)31-18-15-28-25-21-5-1-3-7-23(21)29-24-8-4-2-6-22(24)25;;;;/h1-12H,13-18H2,(H,28,29);4*1H
  • InChiKey: LDBOUNKDAIDIQK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0051
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0034 0.0028 0.0537
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0405 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0043
Entamoeba histolytica hypothetical protein 0.0121 0.0138 0.277
Leishmania major glycerol uptake protein, putative 0.0405 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0072
Brugia malayi hypothetical protein 0.0013 0.0002 0.0003
Leishmania major hypothetical protein, conserved 0.0013 0.0001 0.0003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0109 0.0123 0.7153
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0039 0.0034 0.0058
Onchocerca volvulus 0.028 0.0339 0.6028
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0032 0.0026 0.1443
Schistosoma mansoni hypothetical protein 0.006 0.0061 0.0103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Echinococcus granulosus RUN 0.002 0.0011 0.0018
Onchocerca volvulus 0.0046 0.0043 0.0743
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0076 0.1329
Plasmodium vivax patched family protein, putative 0.0013 0.0002 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0001 0.0003
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0013 0.0001 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.0035 0.003 0.0577
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0081 0.0088 0.1536
Schistosoma mansoni retinal dehydrogenase 0.0013 0.0001 0.0002
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0039 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.009 0.0099 0.0168
Onchocerca volvulus 0.0109 0.0123 0.2177
Plasmodium falciparum thioredoxin reductase 0.0035 0.003 0.058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Brugia malayi hypothetical protein 0.002 0.0011 0.0018
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0018 0.0031
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.0225 0.038
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0016 0.0195
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0058 0.1144
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.003 0.058
Trichomonas vaginalis esterase, putative 0.0072 0.0076 0.1519
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.003 0.058
Trypanosoma cruzi PAB1-binding protein , putative 0.0132 0.0152 0.3045
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0039 0.0034 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0111 0.0187
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0085 0.0092 0.0155
Schistosoma mansoni zinc finger protein 0.4694 0.5919 1
Echinococcus multilocularis nAChR subunit 0.0046 0.0043 0.0043
Brugia malayi hypothetical protein 0.0013 0.0002 0.0003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0035 0.2002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0032 0.0026 0.1443
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0059 0.006 0.006
Brugia malayi CXXC zinc finger family protein 0.003 0.0023 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0006 0.0109
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0258 0.0311 0.5478
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.003 0.0787
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0032 0.0026 0.1443
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0001 0.0003
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0034 0.0028 0.0537
Loa Loa (eye worm) follicle stimulating hormone receptor 0.05 0.0617 0.1043
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0035 0.0933
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0027 0.0019 0.0364
Echinococcus multilocularis Niemann Pick C1 protein 0.0316 0.0384 0.0384
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0007 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0002 0.0017
Mycobacterium ulcerans lipase LipD 0.0072 0.0076 0.4423
Loa Loa (eye worm) hypothetical protein 0.0109 0.0123 0.0207
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Leishmania major pteridine reductase 1 0.0013 0.0001 0.0003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0092 0.0155
Echinococcus granulosus Niemann Pick C1 protein 0.0316 0.0384 0.0649
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0026 0.0496
Plasmodium falciparum ataxin-2 like protein, putative 0.0132 0.0152 0.3043
Brugia malayi hypothetical protein 0.0085 0.0093 0.0157
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0011 0.0011
Brugia malayi hypothetical protein 0.0457 0.0562 0.095
Schistosoma mansoni blooms syndrome DNA helicase 0.0029 0.0022 0.0036
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0093 0.0158
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0026 0.0498
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Schistosoma mansoni acetylcholine receptor subunit beta 0.0039 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0007 0.0116
Echinococcus granulosus Protein patched homolog 1 0.0095 0.0105 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Leishmania major short chain dehydrogenase, putative 0.0034 0.0028 0.0544
Schistosoma mansoni topbp1 0.0034 0.0028 0.0047
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.0001 0.0001
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0046 0.0043 0.0072
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0092 0.0155
Loa Loa (eye worm) doublecortin family protein 0.002 0.0011 0.0018
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0032 0.0026 0.0434
Echinococcus granulosus dna polymerase kappa 0.0042 0.0039 0.0065
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0047
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0011 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.0132 0.0152 0.3043
Entamoeba histolytica hypothetical protein 0.0121 0.0138 0.277
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Echinococcus granulosus carbonyl reductase 1 0.0034 0.0028 0.0047
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.0149 0.0252
Onchocerca volvulus 0.0013 0.0002 0.002
Plasmodium vivax SET domain protein, putative 0.0036 0.003 0.0596
Onchocerca volvulus Protein patched homolog 0.0013 0.0002 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0082 0.1436
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0405 0.0496 0.0839
Echinococcus multilocularis Niemann Pick C1 protein 0.0221 0.0264 0.0264
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.003 0.058
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.0026 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0092 0.0155
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0037 0.0032 0.0555
Echinococcus multilocularis zinc finger protein 0.4289 0.5407 0.5407
Trypanosoma cruzi trypanothione reductase, putative 0.0102 0.0114 0.2278
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0026 0.0498
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0232 0.0278 0.49
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0085 0.0092 0.0155
Echinococcus multilocularis replication factor c subunit 1 0.0034 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.019 0.0225 0.038
Echinococcus granulosus glycine receptor subunit beta 0.0085 0.0092 0.0155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.003 0.0582
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0032 0.0628
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0076 0.0081 0.2573
Echinococcus granulosus zinc finger protein 0.4289 0.5407 0.9136
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Brugia malayi Pre-SET motif family protein 0.0036 0.003 0.0051
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0013 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0043
Echinococcus granulosus thioredoxin glutathione reductase 0.0102 0.0114 0.0192
Plasmodium vivax acyl-CoA synthetase, putative 0.0081 0.0088 0.1755
Echinococcus multilocularis sterol regulatory element binding protein 0.0095 0.0105 0.0105
Brugia malayi MBOAT family protein 0.0405 0.0496 0.0839
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0149
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0071 0.012
Brugia malayi hypothetical protein 0.0034 0.0028 0.0047
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0015 0.0026
Schistosoma mansoni DNA polymerase eta 0.0015 0.0004 0.0007
Onchocerca volvulus Protein patched homolog 0.0013 0.0002 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0111 0.0187
Echinococcus granulosus carbonyl reductase 1 0.0034 0.0028 0.0047
Echinococcus multilocularis dihydrofolate reductase 0.0076 0.0081 0.0081
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0013 0.0001 0.0003
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0071 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.003 0.0582
Schistosoma mansoni nAChR subunit 0.0085 0.0092 0.0155
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0046 0.0043 0.0072
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0039 0.0034 0.0058
Onchocerca volvulus Putative nachr subunit 0.0085 0.0092 0.1621
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0076 0.1329
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0035 0.0688
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0004 0.0007
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0085 0.0092 0.0155
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0092 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0111 0.0187
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.0026 0.0792
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.009 0.0099 0.1988
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Schistosoma mansoni carbonyl reductase 0.0034 0.0028 0.0047
Brugia malayi hypothetical protein 0.0013 0.0001 0.0002
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Brugia malayi hypothetical protein 0.0039 0.0034 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Echinococcus multilocularis carbonyl reductase 1 0.0034 0.0028 0.0028
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0034 0.0028 0.0047
Brugia malayi protein C24B5.3 0.0013 0.0002 0.0003
Brugia malayi DKFZp564C0469 protein 0.0034 0.0028 0.0047
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0092 0.0155
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0035 0.0035
Echinococcus multilocularis oxidoreductase 0.0013 0.0001 0.0001
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.003 0.005
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0013 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0026 0.0498
Entamoeba histolytica hypothetical protein 0.0121 0.0138 0.277
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0004 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0169 0.0285
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0013 0.0001 0.0002
Mycobacterium ulcerans beta-lactamase 0.0072 0.0076 0.4423
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.003 0.058
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0026 0.1443
Leishmania major hypothetical protein, conserved 0.0013 0.0001 0.0003
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0013 0.0001 0.0002
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.0001 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0035 0.0059
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0455 0.056 0.0946
Loa Loa (eye worm) MBOAT family protein 0.0405 0.0496 0.0839
Trypanosoma cruzi GUP1, putative 0.0405 0.0496 1
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0032 0.0026 0.0792
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0085 0.0092 0.0092
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0035 0.0602
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.003 0.0051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0092 0.0155
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0071 0.1419
Giardia lamblia DINP protein human, muc B family 0.0022 0.0013 0.0318
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0085 0.0092 0.0155
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.0366 0.7339
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0034 0.0028 0.0537
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0085 0.0092 0.0092
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0032 0.0026 0.0434
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0072
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0093 0.0158
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0085 0.0092 0.0155
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0066 0.0112
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0102 0.0114 0.1991
Echinococcus granulosus replication factor c subunit 1 0.0034 0.0028 0.0047
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0085 0.0092 0.0155
Trypanosoma cruzi PAB1-binding protein , putative 0.0132 0.0152 0.3045
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Onchocerca volvulus 0.0013 0.0002 0.002
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0139 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0016 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Onchocerca volvulus 0.0034 0.0028 0.0474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0082 0.1436
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0039 0.0763
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0221 0.0264 0.5316
Giardia lamblia Replication factor C, subunit 1 0.0034 0.0028 0.0729
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0076 0.0081 0.1613
Schistosoma mansoni hypothetical protein 0.0405 0.0496 0.0839
Schistosoma mansoni ap endonuclease 0.0039 0.0035 0.0059
Trypanosoma cruzi FHA domain containing protein, putative 0.0034 0.0028 0.054
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Echinococcus multilocularis nAChR subunit 0.0085 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0035 1
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.003 0.0587
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0047
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.009 0.0099 0.1739
Toxoplasma gondii patched family protein 0.0013 0.0002 0.0022
Schistosoma mansoni hypothetical protein 0.0718 0.0892 0.1507
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0011 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0109 0.0123 0.7153
Loa Loa (eye worm) hypothetical protein 0.0457 0.0562 0.095
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0085 0.0092 0.0155
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0004 0.0064
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0076 0.1519
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Brugia malayi Doublecortin family protein 0.002 0.0011 0.0018
Schistosoma mansoni ap endonuclease 0.0039 0.0035 0.0059
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0085 0.0092 0.0155
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.003 0.058
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0072 0.0076 0.0129
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Schistosoma mansoni acetyl-CoA synthetase 0.0032 0.0026 0.0043
Echinococcus granulosus dnaJ subfamily B 0.0422 0.0518 0.0875
Echinococcus multilocularis retinol dehydrogenase 13 0.0013 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.003 0.0051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Brugia malayi hypothetical protein 0.0013 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0028 0.0537
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0032 0.0026 0.0496
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.003 0.1687
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0013 0.0001 0.0002
Schistosoma mansoni patched 1 0.0095 0.0105 0.0177
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0034 0.0028 0.0537
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0026 0.0509
Brugia malayi AMP-binding enzyme family protein 0.0109 0.0123 0.0207
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0076 0.0129
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.0026 0.0691
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0034 0.0058
Toxoplasma gondii carbonyl reductase 1, putative 0.0034 0.0028 0.0541
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.003 0.0582
Onchocerca volvulus 0.0026 0.0018 0.0306
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0004 0.0053
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.006 0.0061 0.0103
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0092 0.0155
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0013 0.0001 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0076 0.1329
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Onchocerca volvulus 0.0086 0.0093 0.1648
Trypanosoma cruzi glycerol uptake protein, putative 0.0405 0.0496 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0026 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0105 0.2099
Toxoplasma gondii ATPase, AAA family protein 0.0034 0.0028 0.0537
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0028 0.054
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0001 0.0003
Entamoeba histolytica recQ family helicase, putative 0.0016 0.0005 0.0086
Echinococcus granulosus o acyltransferase membrane bound domain 0.0405 0.0496 0.0839
Echinococcus multilocularis carbonyl reductase 1 0.0034 0.0028 0.0028
Brugia malayi SET domain containing protein 0.0012 0 0.0001
Leishmania major glycerol uptake protein, putative 0.0405 0.0496 1
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0039 0.0039
Leishmania major short chain dehydrogenase/reductase, putative 0.0013 0.0001 0.0003
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0013 0.0001 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Schistosoma mansoni acetylcholine receptor-related 0.0039 0.0034 0.0058
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0085 0.0092 0.0155
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0076 0.1519
Entamoeba histolytica vacuolar protein sorting 26 0.0405 0.0496 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0092 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0111 0.0187
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0405 0.0496 0.0839
Trichomonas vaginalis chromobox protein, putative 0.0062 0.0063 0.1252
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0026 0.1443
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0015 0.0254
Brugia malayi Hhat protein 0.0405 0.0496 0.0839
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0035 0.0688
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0034 0.0028 0.054
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0039 0.076
Loa Loa (eye worm) GABA receptor subunit 0.0046 0.0043 0.0072
Mycobacterium ulcerans epimerase 0.0024 0.0015 0.0836
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.0366 1
Leishmania major glycerol uptake protein, putative 0.0405 0.0496 1
Brugia malayi Patched protein homolog 1 0.0013 0.0002 0.0003
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0039 0.0034 0.0058
Brugia malayi Myosin head containing protein 0.0013 0.0002 0.0003
Echinococcus granulosus chromobox protein 1 0.0062 0.0063 0.0106
Schistosoma mansoni chromosome transmission fidelity factor 0.0034 0.0028 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0132 0.0152 0.3043
Leishmania major 3-keto-dihydrosphingosine reductase 0.0013 0.0001 0.0003
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0032 0.0026 0.1443
Echinococcus multilocularis glycine receptor subunit beta 0.0085 0.0092 0.0092
Schistosoma mansoni polycystin 1-related 0.002 0.0011 0.0018
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0071 0.1419
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0026 0.1443
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) oxidoreductase 0.0032 0.0026 0.0043
Loa Loa (eye worm) TAR-binding protein 0.0145 0.0169 0.0285
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0092 0.0155
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.0034 0.0058
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0085 0.0092 0.0155
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0232 0.0278 0.49
Echinococcus multilocularis carbonyl reductase 1 0.0034 0.0028 0.0028
Brugia malayi Latrophilin receptor protein 2 0.006 0.0061 0.0103
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0013 0.0001 0.0001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.003 0.0596
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.003 0.058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Schistosoma mansoni carbonyl reductase 0.0021 0.0012 0.002
Brugia malayi dihydrofolate reductase family protein 0.0076 0.0081 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Loa Loa (eye worm) hypothetical protein 0.0072 0.0076 0.0129
Echinococcus granulosus steroid dehydrogenase 0.0013 0.0001 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0011 0.0011
Echinococcus multilocularis chromobox protein 1 0.0062 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0116 0.0132 0.0223
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.0225 0.038
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.003 0.1687
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0026 0.0498
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Plasmodium falciparum glutathione reductase 0.0102 0.0114 0.2275
Brugia malayi dehydrogenases, short chain protein 2 0.0013 0.0001 0.0002
Schistosoma mansoni cpg binding protein 0.0031 0.0025 0.0042
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0405 0.0496 0.0839
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0034 0.0028 0.0537
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.003
Schistosoma mansoni dihydrofolate reductase 0.0076 0.0081 0.0136
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0071 0.012
Schistosoma mansoni carbonyl reductase 0.0034 0.0028 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0043
Trypanosoma cruzi glycerol uptake protein, putative 0.0405 0.0496 1
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0123 0.0207
Loa Loa (eye worm) hhat protein 0.0405 0.0496 0.0839
Echinococcus granulosus geminin 0.0718 0.0892 0.1507
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0001 0.0002
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0405 0.0496 0.0496
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0043 0.0073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0076 0.0129
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.009 0.0099 0.0168
Onchocerca volvulus 0.0027 0.0019 0.0327
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0032 0.0026 0.0496
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0042 0.0072
Brugia malayi hypothetical protein 0.0013 0.0002 0.0003
Brugia malayi Pre-SET motif family protein 0.0246 0.0296 0.0501
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0082 0.1436
Leishmania major acetyl-CoA synthetase, putative 0.0032 0.0026 0.0498
Loa Loa (eye worm) hypothetical protein 0.0535 0.0662 0.1118
Echinococcus multilocularis lamin 0.0026 0.0018 0.0018
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0405 0.0496 0.0496
Echinococcus granulosus oxidoreductase 0.0013 0.0001 0.0002
Schistosoma mansoni lipoxygenase 0.0085 0.0093 0.0156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0111 0.0187
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Schistosoma mansoni neurotransmitter gated ion channel 0.0046 0.0043 0.0072
Schistosoma mansoni hypothetical protein 0.0718 0.0892 0.1507
Schistosoma mansoni lamin 0.0026 0.0018 0.0031
Schistosoma mansoni intermediate filament proteins 0.0026 0.0018 0.0031
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0013 0.0001 0.0002
Onchocerca volvulus 0.0039 0.0034 0.0596
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0034 0.0028 0.1563
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0047
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0042 0.0838
Schistosoma mansoni cellular tumor antigen P53 0.0162 0.019 0.0321
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0405 0.0496 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0004 0.0004
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0405 0.0496 0.0839
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0109 0.0123 0.7153
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.003 0.005
Echinococcus multilocularis conserved hypothetical protein 0.0013 0.0001 0.0001
Trichomonas vaginalis chromobox protein, putative 0.0062 0.0063 0.1252
Schistosoma mansoni rab6-interacting 0.002 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Brugia malayi MBOAT family protein 0.0405 0.0496 0.0839
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0035 0.0059
Loa Loa (eye worm) LGC-31 protein 0.0085 0.0092 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0026 0.0043
Leishmania major trypanothione reductase 0.0102 0.0114 0.2278
Echinococcus multilocularis survival motor neuron protein 1 0.0535 0.0662 0.0662
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0006 0.0109
Loa Loa (eye worm) hypothetical protein 0.0221 0.0264 0.0447
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0047
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0039 0.2213
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0028 0.0537
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0405 0.0496 0.0839
Echinococcus granulosus hypothetical protein 0.0013 0.0001 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0032 0.0026 0.1443
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0013 0.0001 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0246 0.0296 0.0501
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0016 0.0295
Brugia malayi AMP-binding enzyme family protein 0.0109 0.0123 0.0207
Plasmodium vivax replication factor C subunit 1, putative 0.0034 0.0028 0.0537
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0016 0.086
Chlamydia trachomatis dihydrofolate reductase 0.0076 0.0081 0.777
Mycobacterium tuberculosis Probable oxidoreductase 0.0258 0.0311 0.5478
Schistosoma mansoni rab6-interacting 0.002 0.0011 0.0018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0109 0.0123 0.3925
Echinococcus granulosus carbonyl reductase 1 0.0021 0.0012 0.002
Brugia malayi chromobox protein homolog 3 0.0035 0.0029 0.0049
Entamoeba histolytica hypothetical protein 0.0024 0.0016 0.0295
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0006 0.0109
Brugia malayi Dihydrofolate reductase 0.0076 0.0081 0.0136
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Onchocerca volvulus 0.0455 0.056 0.9963
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0028 0.0047
Loa Loa (eye worm) hypothetical protein 0.0072 0.0076 0.0129
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0013 0.0001 0.0003
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0405 0.0496 1
Echinococcus multilocularis musashi 0.0026 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0092 0.0155
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0121 0.0138 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0109 0.0123 0.7153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Echinococcus granulosus hypothetical protein 0.0013 0.0001 0.0002
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0013 0.0001 0.0003
Brugia malayi Pax transcription activation domain interacting protein 0.0034 0.0028 0.0047
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Onchocerca volvulus 0.0085 0.0092 0.1621
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0072
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0081 0.0088 0.511
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Schistosoma mansoni nAChR subunit 0.0039 0.0034 0.0058
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0039 0.2213
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.4694 0.5919 0.5919
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0001 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0023 0.0038
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0034 0.0028 0.781
Schistosoma mansoni carbonyl reductase 0.0034 0.0028 0.0047
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0076 0.0129
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0071 0.1416
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.0567 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0139 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0093 0.0158
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.003 0.058
Trypanosoma brucei glycerol uptake protein, putative 0.0405 0.0496 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0001 0.0001
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0013 0.0001 0.0002
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0016 0.4294
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.003 0.003
Schistosoma mansoni survival motor neuron protein 0.0109 0.0123 0.0208
Plasmodium vivax acetyl-CoA synthetase, putative 0.0032 0.0026 0.0496
Echinococcus multilocularis carbonyl reductase 1 0.0021 0.0012 0.0012
Trichomonas vaginalis porcupine, putative 0.0405 0.0496 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0018
Leishmania major acetyl-CoA synthetase, putative 0.0032 0.0026 0.0498
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0085 0.0092 0.0155
Echinococcus multilocularis tar DNA binding protein 0.0145 0.0169 0.0169
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0072 0.0076 0.0129
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0405 0.0496 0.0839
Brugia malayi hypothetical protein 0.0121 0.0138 0.0234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.003 0.0582
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0092 0.0155
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0085 0.0092 0.0155
Onchocerca volvulus 0.003 0.0023 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0405 0.0496 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.003 0.168
Echinococcus multilocularis carbonyl reductase 1 0.0034 0.0028 0.0028
Brugia malayi hypothetical protein 0.0039 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.0076 0.0129
Echinococcus multilocularis Protein lozenge 0.0057 0.0058 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0076 0.1519
Leishmania major hypothetical protein, conserved 0.0013 0.0001 0.0003
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.0001 0.0001
Leishmania major DNA polymerase eta, putative 0.0015 0.0004 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0026 0.0434
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0026 0.1443
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0013 0.0001 0.0003
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0085 0.0092 0.0155
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0121 0.0138 0.0234
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0061 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.003 0.0582
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0026 0.0434
Loa Loa (eye worm) hypothetical protein 0.0162 0.019 0.0321
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0006 0.0109
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0013 0.0001 0.0001
Brugia malayi MBOAT family protein 0.0405 0.0496 0.0839
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0035 0.0688
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Brugia malayi Cation transporter family protein 0.0455 0.056 0.0946
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Mycobacterium ulcerans hypothetical protein 0.0072 0.0076 0.4423
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0085 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0091 0.0101 0.017
Onchocerca volvulus 0.0162 0.019 0.3368
Onchocerca volvulus 0.0085 0.0092 0.1621
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.003 0.0577
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0032 0.0026 0.0434
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0085 0.0092 0.0092
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0026 0.0434
Loa Loa (eye worm) MBOAT family protein 0.4694 0.5919 1
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.003 0.0582
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0001
Onchocerca volvulus 0.0034 0.0028 0.0477
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0092 0.0155
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0039 0.076
Loa Loa (eye worm) patched family protein 0.0013 0.0002 0.0003
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0076 0.0081 0.1409
Echinococcus granulosus lamin 0.0026 0.0018 0.0031
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0013 0.0234
Brugia malayi dehydrogenases, short chain protein 9 0.0013 0.0001 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.003 0.003
Echinococcus multilocularis carbonyl reductase 1 0.0021 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.003 0.843
Brugia malayi Retinol dehydrogenase 12 0.0013 0.0001 0.0002
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.0026 0.0044
Schistosoma mansoni nAChR subunit 0.0085 0.0092 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0029 0.0561
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0061 0.0103
Brugia malayi excitatory GABA receptor EXP-1A 0.0085 0.0092 0.0155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0035 0.069
Schistosoma mansoni nAChR subunit 0.0085 0.0092 0.0155
Echinococcus multilocularis cpg binding protein 0.0031 0.0025 0.0025
Leishmania major glycerol uptake protein, putative 0.0405 0.0496 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0034 0.0028 0.0537
Loa Loa (eye worm) hypothetical protein 0.0405 0.0496 0.0839
Echinococcus granulosus sterol O acyltransferase 1 0.0405 0.0496 0.0839
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0405 0.0496 0.0839
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Schistosoma mansoni topbp1 0.0034 0.0028 0.0047
Schistosoma mansoni hypothetical protein 0.0091 0.0101 0.017
Schistosoma mansoni lamin 0.0026 0.0018 0.0031
Echinococcus granulosus o acyltransferase membrane bound domain 0.0405 0.0496 0.0839
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0092 0.0155
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0086 0.0093 0.0158
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0092 0.0092
Chlamydia trachomatis endonuclease IV 0.009 0.0099 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0035 0.069
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0026 0.0498
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.0034 0.0058
Trichomonas vaginalis antibiotic synthetase, putative 0.0032 0.0026 0.0496
Loa Loa (eye worm) dihydrofolate reductase 0.0076 0.0081 0.0136
Schistosoma mansoni loxhd1 0.002 0.0011 0.0018
Leishmania major oxidoreductase-like protein 0.0013 0.0001 0.0003
Onchocerca volvulus 0.0032 0.0026 0.0438
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0405 0.0496 0.0496
Schistosoma mansoni hypothetical protein 0.0422 0.0518 0.0875
Brugia malayi hypothetical protein 0.0535 0.0662 0.1118
Echinococcus granulosus GPCR family 2 0.006 0.0061 0.0103
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0232 0.0278 0.49
Brugia malayi hypothetical protein 0.0034 0.0028 0.0047
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0258 0.0311 1
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0076 0.1519
Mycobacterium ulcerans acyl-CoA synthetase 0.0109 0.0123 0.7153
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0034 0.0028 0.0858
Leishmania major short chain dehydrogenase, putative 0.0013 0.0001 0.0003
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.009 0.0099 0.3176
Echinococcus multilocularis protein dispatched 1 0.0108 0.0122 0.0122
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0003 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0169 0.0285
Loa Loa (eye worm) hypothetical protein 0.0405 0.0496 0.0839
Schistosoma mansoni hypothetical protein 0.0091 0.0101 0.017
Echinococcus granulosus Niemann Pick C1 protein 0.0221 0.0264 0.0447
Trichomonas vaginalis replication factor C large subunit, putative 0.0034 0.0028 0.0537
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0111 0.0187
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0076 0.1329
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0016 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0028 0.054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0015 0.0251
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.003 0.0582
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Loa Loa (eye worm) ACC-1 protein 0.0085 0.0092 0.0155
Brugia malayi MBOAT family protein 0.4694 0.5919 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0109 0.0123 0.7153
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0011 0.0199
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0006 0.0106
Onchocerca volvulus 0.0109 0.0123 0.2169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0006 0.0109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0006 0.0109
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0032 0.0026 0.0043
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0455 0.056 0.0946
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0072
Brugia malayi topoisomerase 0.0034 0.0028 0.0047
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.003 0.0582
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Echinococcus multilocularis expressed conserved protein 0.0208 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0149
Plasmodium vivax ataxin-2 like protein, putative 0.0132 0.0152 0.3043
Plasmodium vivax glutathione reductase, putative 0.0102 0.0114 0.2275
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0018 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0001 0.0003
Echinococcus granulosus bloom syndrome protein 0.0045 0.0042 0.0072
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0092 0.0155
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0081 0.0088 0.8624
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0015 0.0836
Echinococcus multilocularis protein patched 0.0095 0.0105 0.0105
Brugia malayi Heterochromatin protein 1 0.0062 0.0063 0.0106
Onchocerca volvulus 0.002 0.0011 0.0176
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0035 0.0688
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Echinococcus multilocularis RUN 0.002 0.0011 0.0011
Loa Loa (eye worm) RNA binding protein 0.0145 0.0169 0.0285
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0416 0.0511 0.0863
Echinococcus multilocularis nibrin 0.0034 0.0028 0.0028
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0061 0.0103
Mycobacterium ulcerans hypothetical protein 0.0024 0.0015 0.0836
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0026 0.1443
Plasmodium vivax thioredoxin reductase, putative 0.0102 0.0114 0.2275
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0085 0.0092 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0059 0.006 0.0101
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0171 0.5486
Onchocerca volvulus 0.0013 0.0002 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0035 0.069
Plasmodium falciparum lipid/sterol:H+ symporter 0.0013 0.0002 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0169 0.0285
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0039 0.0034 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0076 0.1522
Echinococcus granulosus tumor protein p63 0.1107 0.1385 0.234
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.003 0.058
Loa Loa (eye worm) dehydrogenase 0.0013 0.0001 0.0002
Plasmodium falciparum thioredoxin reductase 0.0102 0.0114 0.2275
Loa Loa (eye worm) glutathione reductase 0.0102 0.0114 0.0192
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0026 0.1443
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.003 0.058
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0085 0.0092 0.0155
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0026
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0076 0.0076
Toxoplasma gondii exonuclease III APE 0.0039 0.0035 0.0688
Trypanosoma brucei unspecified product 0.0036 0.003 0.0587
Brugia malayi beta-lactamase family protein 0.0072 0.0076 0.0129
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0455 0.056 0.0946
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.003 0.058
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0405 0.0496 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0085 0.0092 0.0092
Brugia malayi Cation transporter family protein 0.0085 0.0092 0.0155
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0039 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0405 0.0496 0.0839
Echinococcus granulosus nAChR subunit 0.0046 0.0043 0.0072
Echinococcus granulosus carbonyl reductase 1 0.0034 0.0028 0.0047
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0405 0.0496 0.0839
Onchocerca volvulus 0.0085 0.0092 0.1621
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0035 0.0688
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0032 0.0026 0.0496
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0076 0.1329
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0015 0.0459
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0061 0.0103
Loa Loa (eye worm) beta-lactamase 0.0072 0.0076 0.0129
Brugia malayi polk-prov protein 0.0032 0.0026 0.0043
Trypanosoma cruzi short chain dehydrogenase, putative 0.0034 0.0028 0.0544
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0016 0.0298
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0061 0.0103
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0046 0.0043 0.0072
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0085 0.0092 0.0155
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0035 0.0591
Loa Loa (eye worm) acetylcholine receptor protein 0.0039 0.0034 0.0058
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0085 0.0092 0.0155
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0039 0.0763
Schistosoma mansoni hypothetical protein 0.006 0.0061 0.0103
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0006 0.001
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0026 0.0043
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0016 0.0295
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0085 0.0092 0.0092
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0029 0.0495
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0018 0.003
Brugia malayi Thioredoxin reductase 0.0102 0.0114 0.0192
Brugia malayi hypothetical protein 0.0132 0.0152 0.0256
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0035 0.0688
Brugia malayi follicle stimulating hormone receptor 0.05 0.0617 0.1043
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.003 0.0582
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0035 0.0059
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0109 0.0123 0.215
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Brugia malayi hypothetical protein 0.0039 0.0034 0.0058
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0032 0.0026 0.0043
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.0026 0.0044
Schistosoma mansoni cpg binding protein 0.003 0.0023 0.0038
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0076 0.1519
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0028 0.0537
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.4694 0.5919 1
Echinococcus granulosus cpg binding protein 0.0031 0.0025 0.0042
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0032 0.0026 0.0026
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0032 0.0026 0.1443
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0076 0.0081 0.1611
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0405 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0085 0.0092 0.0155
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0013 0.0001 0.0001
Entamoeba histolytica recQ family helicase, putative 0.0035 0.003 0.0577
Onchocerca volvulus 0.0072 0.0076 0.1341
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.003 0.0507
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0016 0.086
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0032 0.0026 0.1443
Echinococcus granulosus expressed conserved protein 0.0208 0.0247 0.0418
Entamoeba histolytica hypothetical protein 0.0121 0.0138 0.277
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Trypanosoma brucei trypanothione reductase 0.0102 0.0114 0.2275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.003 0.0051
Toxoplasma gondii patched family protein 0.0013 0.0002 0.0022
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0046 0.0043 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0049
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0059 0.006 0.0101
Echinococcus granulosus tar DNA binding protein 0.0145 0.0169 0.0285
Leishmania major dehydrogenase-like protein 0.0013 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0028 0.0537
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.006 0.0061 0.0103
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0026 0.0044
Schistosoma mansoni transcription factor LCR-F1 0.0121 0.0138 0.0234
Trypanosoma cruzi GUP1, putative 0.0405 0.0496 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0039 0.0763
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0046 0.0043 0.0072
Loa Loa (eye worm) ACC-1 protein 0.0085 0.0092 0.0155
Loa Loa (eye worm) hypothetical protein 0.0405 0.0496 0.0839
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.003 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0171 1
Echinococcus multilocularis chromobox protein 1 0.0062 0.0063 0.0063
Schistosoma mansoni cpg binding protein 0.0031 0.0025 0.0042
Onchocerca volvulus 0.0013 0.0002 0.002
Echinococcus granulosus nibrin 0.0034 0.0028 0.0047
Schistosoma mansoni chromobox protein 0.0062 0.0063 0.0106
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0232 0.0278 0.49
Brugia malayi Niemann-Pick C1 protein precursor 0.0221 0.0264 0.0447
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0047
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0039 0.076
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0001 0.0003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0018 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0169 0.0285
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0171 0.3005
Toxoplasma gondii endonuclease IV APN 0.009 0.0099 0.1988
Leishmania major 4-coumarate:coa ligase-like protein 0.0109 0.0123 0.2459
Loa Loa (eye worm) hypothetical protein 0.0072 0.0076 0.0129
Echinococcus multilocularis dna polymerase eta 0.0015 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0076 0.1522
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0149
Schistosoma mansoni lozenge 0.0057 0.0058 0.0097
Onchocerca volvulus 0.0013 0.0002 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0026 0.1443
Echinococcus granulosus lamin dm0 0.0026 0.0018 0.0031
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0085 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0016 0.0005 0.0086
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0076 0.2427
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Leishmania major glycerol uptake protein, putative 0.0405 0.0496 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0039 0.0034 0.0058
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0258 0.0311 0.5478
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0111 0.0187
Trypanosoma brucei glycerol uptake protein, putative 0.0405 0.0496 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0076 0.1329
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0085 0.0092 0.0155
Mycobacterium ulcerans acetyl-CoA synthetase 0.0032 0.0026 0.1443
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.0026 0.0044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0035 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0039 0.0763
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0016 0.0295
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Brugia malayi RNA binding protein 0.0145 0.0169 0.0285
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0044
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0013 0.0237
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0013 0.0001 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0076 0.1329
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0072
Onchocerca volvulus 0.0046 0.0043 0.0743
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0011 0.0011
Schistosoma mansoni DNA ligase IV 0.0034 0.0028 0.0047
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0092 0.0155
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.009 0.0099 0.1988
Schistosoma mansoni hypothetical protein 0.0091 0.0101 0.017
Leishmania major short chain dehydrogenase-like protein 0.0013 0.0001 0.0003
Brugia malayi Patched related family protein 4 0.0013 0.0002 0.0003
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0013 0.0001 0.0002
Plasmodium falciparum acyl-CoA synthetase 0.0081 0.0088 0.1755
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0071 0.1416
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0029 0.0561
Treponema pallidum DNA ligase (lig) 0.0034 0.0028 0.0439
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0032 0.0026 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0016 0.0304
Leishmania major short chain dehydrogenase/reductase, putative 0.0013 0.0001 0.0003
Echinococcus multilocularis lamin dm0 0.0026 0.0018 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.003 0.0582
Entamoeba histolytica recQ family DNA helicase 0.0017 0.0006 0.0103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0004 0.0007
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0034 0.0028 0.0537
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0001 0.0003
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Echinococcus granulosus WW domain containing oxidoreductase 0.0013 0.0001 0.0002
Brugia malayi Patched related family protein 12 0.0013 0.0002 0.0003
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0093 0.0093
Entamoeba histolytica acyl-coA synthetase, putative 0.0109 0.0123 0.2457
Loa Loa (eye worm) hhat protein 0.0405 0.0496 0.0839
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0013 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0109 0.0123 0.0207
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Brugia malayi MBOAT family protein 0.0405 0.0496 0.0839
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0111 0.0111
Treponema pallidum NADH oxidase 0.0035 0.003 0.0482
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0004 0.0061
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0013 0.0001 0.0003
Schistosoma mansoni nAChR subunit 0.0085 0.0092 0.0155
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0031
Onchocerca volvulus 0.0455 0.056 0.9963
Loa Loa (eye worm) hypothetical protein 0.013 0.0149 0.0252
Brugia malayi hypothetical protein 0.0013 0.0002 0.0003
Schistosoma mansoni chromobox protein 0.0062 0.0063 0.0106
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0013 0.0001 0.0003
Echinococcus multilocularis glycine receptor subunit beta 0.0085 0.0092 0.0092
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Mycobacterium ulcerans hypothetical protein 0.0109 0.0123 0.7153
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0032 0.0026 0.0498
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0001 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0026 0.1443
Toxoplasma gondii thioredoxin reductase 0.0102 0.0114 0.2275
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0405 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0011 0.0199
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0004 0.0061
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0092 0.0155
Schistosoma mansoni lipoxygenase 0.0122 0.0139 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0028 0.0537
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0076 0.0081 0.4689
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0109 0.0123 0.0208
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0007
Loa Loa (eye worm) runx1 0.0057 0.0058 0.0097
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0013 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0072
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Echinococcus multilocularis GPCR, family 2 0.006 0.0061 0.0061
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0076 0.0081 0.1611
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Toxoplasma gondii ABC1 family protein 0.0072 0.0076 0.1519
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.0225 0.038
Schistosoma mansoni hypothetical protein 0.013 0.0149 0.0252
Brugia malayi Patched related family protein 10 0.0013 0.0002 0.0003
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.003 0.058
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0016 0.0472
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0032 0.0026 0.1443
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0032 0.0026 0.0434
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0018 0.003
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0076 0.0081 0.1611
Echinococcus granulosus intermediate filament protein 0.0026 0.0018 0.0031
Treponema pallidum alginate O-acetylation protein (algI) 0.0405 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0405 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0016 0.0295
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0032 0.0026 0.0043
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0405 0.0496 1
Entamoeba histolytica hypothetical protein 0.0405 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0109 0.0123 0.3925
Echinococcus granulosus glycine receptor subunit beta 0.0085 0.0092 0.0155
Leishmania major DNA polymerase kappa, putative 0.0022 0.0013 0.0237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0076 0.0129
Onchocerca volvulus 0.0039 0.0034 0.0596
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0001 0.0002
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0006 0.0106
Echinococcus multilocularis thioredoxin glutathione reductase 0.0102 0.0114 0.0114
Schistosoma mansoni nAChR subunit 0.0085 0.0092 0.0155
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0085 0.0092 0.0155
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.003 0.0582
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0405 0.0496 0.0839
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0026 0.0434
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0013 0.0001 0.0001
Onchocerca volvulus 0.0039 0.0034 0.0596
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0072
Mycobacterium tuberculosis Probable reductase 0.0232 0.0278 0.49
Trypanosoma cruzi short chain dehydrogenase, putative 0.0034 0.0028 0.0544
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0032 0.0026 0.0434
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0013 0.0001 0.0002
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0043 0.0039 0.077
Entamoeba histolytica hypothetical protein, conserved 0.0405 0.0496 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.003 0.0582
Brugia malayi beta-lactamase 0.0072 0.0076 0.0129
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0042 0.0838
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0076 0.4423
Echinococcus multilocularis tumor protein p63 0.1107 0.1385 0.1385
Brugia malayi Cation transporter family protein 0.0085 0.0092 0.0155
Leishmania major hypothetical protein, conserved 0.0013 0.0001 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.0518 0.0518
Entamoeba histolytica acyl-CoA synthetase, putative 0.0109 0.0123 0.2457
Trypanosoma cruzi glycerol uptake protein, putative 0.0405 0.0496 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0013 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0132 0.0152 0.3045
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0405 0.0496 0.0839
Loa Loa (eye worm) MBOAT family protein 0.0405 0.0496 0.0839
Toxoplasma gondii patched family protein 0.0013 0.0002 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0405 0.0496 1
Brugia malayi RNA recognition motif domain containing protein 0.0145 0.0169 0.0285
Onchocerca volvulus 0.0013 0.0002 0.002
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0016 0.0258
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0109 0.0123 0.0207
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0013 0.0205
Schistosoma mansoni sterol O-acyltransferase 1 0.0405 0.0496 0.0839
Onchocerca volvulus 0.0046 0.0043 0.0753
Toxoplasma gondii hypothetical protein 0.0013 0.0002 0.0022
Brugia malayi oxidoreductase 0.0013 0.0001 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0092 0.0155
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0232 0.0278 0.8945
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0039 0.076
Toxoplasma gondii hypothetical protein 0.0405 0.0496 1
Brugia malayi hypothetical protein 0.0039 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0457 0.0562 0.095
Loa Loa (eye worm) RecQ helicase 0.0045 0.0042 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0111 0.0111
Brugia malayi glutathione reductase 0.0102 0.0114 0.0192
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0001 0.0003
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0039 0.0034 0.0034
Toxoplasma gondii LsmAD domain-containing protein 0.0132 0.0152 0.3043
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.003 0.058
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0032 0.0026 0.0498
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0004 0.0007
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0085 0.0092 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0035 0.0059
Schistosoma mansoni nAChR subunit 0.0039 0.0034 0.0058
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Onchocerca volvulus 0.0072 0.0076 0.1341
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0071 0.1419
Echinococcus multilocularis sterol O acyltransferase 1 0.0405 0.0496 0.0496
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0001 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0006 0.0103
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0013 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0121 0.0138 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0076 0.1519
Entamoeba histolytica acyl-CoA synthetase, putative 0.0109 0.0123 0.2457
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.001
Schistosoma mansoni nAChR subunit 0.0085 0.0092 0.0155
Onchocerca volvulus 0.0013 0.0002 0.002
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.003 0.843
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.003 0.0582
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0034 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0001 0.0003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0145 0.0169 0.0285
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0032 0.0026 0.0792
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0405 0.0496 1
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0001 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0006 0.0109
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0032 0.0026 0.0434
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0169 0.0285
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0026 0.0509
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.002 0.0334
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0455 0.056 0.0946
Echinococcus granulosus carbonyl reductase 1 0.0034 0.0028 0.0047
Loa Loa (eye worm) heterochromatin protein 1 0.0062 0.0063 0.0106
Brugia malayi Patched family protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) thioredoxin reductase 0.0102 0.0114 0.0192
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0013 0.0001 0.0003
Leishmania major hypothetical protein, conserved 0.0072 0.0076 0.1522
Brugia malayi hypothetical protein 0.002 0.0011 0.0018
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0405 0.0496 0.0839
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0034 0.0028 0.0537
Onchocerca volvulus 0.0026 0.0018 0.0306
Onchocerca volvulus 0.0455 0.056 0.9963
Trichomonas vaginalis antibiotic synthetase, putative 0.0032 0.0026 0.0496
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0405 0.0496 0.0839
Brugia malayi Dehydrogenases, short chain protein 30 0.0013 0.0001 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0076 0.1519
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.0026 0.0026
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.003 0.058
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0071 0.012
Schistosoma mansoni DNA helicase recq1 0.0032 0.0026 0.0044
Brugia malayi diacylglycerol acyltransferase 0.0405 0.0496 0.0839
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.003 0.058
Onchocerca volvulus 0.0032 0.0026 0.0438
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0047
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0032 0.0628
Echinococcus granulosus chromobox protein 1 0.0062 0.0063 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0007 0.0116
Loa Loa (eye worm) oxidoreductase 0.0013 0.0001 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.003 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0061 0.0061
Brugia malayi CHE-14 protein 0.0095 0.0105 0.0177
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0038
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0085 0.0092 0.0155
Mycobacterium tuberculosis Probable dehydrogenase 0.0232 0.0278 0.49
Loa Loa (eye worm) hypothetical protein 0.0095 0.0105 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0001 0.0003
Echinococcus granulosus nAChR subunit 0.0085 0.0092 0.0155
Loa Loa (eye worm) dehydrogenase 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0109 0.0123 0.7153
Trichomonas vaginalis set domain proteins, putative 0.028 0.0339 0.6829
Echinococcus granulosus survival motor neuron protein 1 0.0535 0.0662 0.1118
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0026 0.0043
Onchocerca volvulus 0.0072 0.0076 0.1341
Onchocerca volvulus 0.0457 0.0562 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0004 0.0007
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0095 0.0105 0.0177
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0032 0.0026 0.0496
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0076 0.4423
Schistosoma mansoni hypothetical protein 0.006 0.0061 0.0103
Brugia malayi hypothetical protein 0.0039 0.0034 0.0058
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0405 0.0496 1
Mycobacterium ulcerans endonuclease IV 0.009 0.0099 0.5788
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Brugia malayi TAR-binding protein 0.0145 0.0169 0.0285
Toxoplasma gondii propionate-CoA ligase 0.0032 0.0026 0.0496
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0071 0.0071
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0046 0.0043 0.0072
Loa Loa (eye worm) hypothetical protein 0.0132 0.0152 0.0256
Brugia malayi Dehydrogenases, short chain protein 2 0.0013 0.0001 0.0002
Toxoplasma gondii patched family protein 0.0013 0.0002 0.0022
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0076 0.0081 0.1613
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0001 0.0003
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0405 0.0496 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0032 0.0026 0.0434
Echinococcus multilocularis geminin 0.0718 0.0892 0.0892
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.0366 0.7366
Schistosoma mansoni DNA helicase recq5 0.0032 0.0026 0.0044
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.0026 0.0509
Leishmania major quinonoid dihydropteridine reductase 0.0013 0.0001 0.0003
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0003 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0003
Plasmodium falciparum glutathione reductase 0.0035 0.003 0.058
Entamoeba histolytica hypothetical protein 0.0034 0.0028 0.0537
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0076 0.0081 0.1611
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0058
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0032 0.0026 0.0496
Onchocerca volvulus 0.002 0.0011 0.0176
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0011 0.0018
Schistosoma mansoni hypothetical protein 0.0109 0.0123 0.0208
Brugia malayi beta-lactamase family protein 0.0072 0.0076 0.0129
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0039 0.0034 0.0058
Chlamydia trachomatis DNA ligase 0.0034 0.0028 0.1428
Trichomonas vaginalis transmembrane protein nessy, putative 0.0405 0.0496 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0026 0.0018 0.0348
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0028 0.0047
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0149
Mycobacterium tuberculosis Conserved protein 0.0072 0.0076 0.1329
Brugia malayi intermediate filament protein 0.0026 0.0018 0.0031
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0001 0.0002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.003 0.1687
Schistosoma mansoni nAChR subunit 0.0085 0.0092 0.0155
Echinococcus granulosus dihydrofolate reductase 0.0076 0.0081 0.0136
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0076 0.1329
Echinococcus granulosus dna polymerase eta 0.0015 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Onchocerca volvulus 0.0044 0.0041 0.072
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0405 0.0496 0.0496
Mycobacterium tuberculosis Conserved protein 0.0072 0.0076 0.1329
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Echinococcus granulosus sterol regulatory element binding protein 0.0095 0.0105 0.0177
Leishmania major hypothetical protein, conserved 0.0013 0.0001 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0006 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0109 0.0123 0.215
Brugia malayi protein C24B5.3 0.0013 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0039 0.076
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0002
Onchocerca volvulus 0.0032 0.0026 0.0438
Entamoeba histolytica hypothetical protein 0.0046 0.0043 0.0842
Leishmania major hypothetical protein, conserved 0.0405 0.0496 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0224 0.0269 0.0454
Loa Loa (eye worm) hypothetical protein 0.0085 0.0092 0.0155
Onchocerca volvulus 0.0405 0.0496 0.8828
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0082 0.1436
Leishmania major 4-coumarate:coa ligase-like protein 0.0109 0.0123 0.2459
Echinococcus granulosus o acyltransferase membrane bound domain 0.0405 0.0496 0.0839
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0076 0.0129
Mycobacterium leprae Probable lipase LipE 0.0072 0.0076 0.2427
Leishmania major 4-coumarate:coa ligase-like protein 0.0109 0.0123 0.2459

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.372 uM Cytotoxicity against P388 leukemia cell line ChEMBL. 2231599
ILS (functional) = 37 % Increase in life span of the drug treated animals against P388 leukemia when treated at a optimal dose of 65 mg/kg ChEMBL. 2231599
OD (functional) = 65 mg kg-1 Optimal dose (i.p.) given after inoculation with wild type 10 E 6 P388/W leukemia cell lines, measured on day 1 ChEMBL. 2231599

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 2231599

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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