Detailed information for compound 20403

Basic information

Technical information
  • TDR Targets ID: 20403
  • Name: 4,5-dihydro-1H-benzo[g]indazole
  • MW: 170.21 | Formula: C11H10N2
  • H donors: 1 H acceptors: 1 LogP: 2.17 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc2c(c1)c1n[nH]cc1CC2
  • InChi: 1S/C11H10N2/c1-2-4-10-8(3-1)5-6-9-7-12-13-11(9)10/h1-4,7H,5-6H2,(H,12,13)
  • InChiKey: IJZPDJZOELSEKV-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0148 0.0146
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.0066 0.1067
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0011 0.001
Brugia malayi hypothetical protein 0.003 0.006 0.0128
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.0437 0.0435
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0027 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0032 0.003
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0015 0.0013
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0075 0.0215 0.3472
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0075 0.0215 0.3646
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0027 0.0025
Schistosoma mansoni hypothetical protein 0.0523 0.174 0.1739
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0014 0.0006 0.001
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.0255 0.0827 0.0825
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0016 0.0027
Onchocerca volvulus 0.1528 0.5167 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0027 0.0025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0049 0.0047
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0014 0.0006 0.0018
Brugia malayi hypothetical protein 0.0106 0.032 0.0702
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0063 0.0135
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.007 0.0636
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0016 0.0176
Mycobacterium ulcerans dehydrogenase 0.0017 0.0016 0.0057
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0168 0.0167
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0136 0.0421 0.0419
Loa Loa (eye worm) hypothetical protein 0.0106 0.032 0.0702
Schistosoma mansoni 6-phosphofructokinase 0.0238 0.0769 0.0767
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0129 0.1181
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0083 0.0153
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0016 0.0134
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0016 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Brugia malayi hypothetical protein 0.0019 0.0024 0.0049
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0038 0.0441
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0476 0.0474
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0064 0.0176 0.0174
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0083 0.0748
Leishmania major basic transcription factor 3a, putative 0.0116 0.0354 0.3257
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.0118 0.0219
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0044 0.0042
Schistosoma mansoni ap endonuclease 0.002 0.0026 0.0024
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0083 0.0153
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0016 0.0263
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0026 0.0053
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0064 0.0176 0.1614
Schistosoma mansoni hypothetical protein 0.0301 0.0984 0.0982
Toxoplasma gondii selenide, water dikinase 0.0017 0.0016 0.0176
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0017 0.0016 0.0057
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0017 0.0016 0.0057
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0043 0.0386
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0467 0.155 0.6037
Loa Loa (eye worm) aldehyde dehydrogenase 0.0014 0.0006 0.001
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0274 0.0601
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0026 0.0093
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0016 0.0263
Brugia malayi mbt repeat family protein 0.0049 0.0125 0.0272
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0036 0.0034
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0176 0.8178
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0064 0.0177 0.0332
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0188 0.0601 0.0599
Onchocerca volvulus 0.0267 0.087 0.1681
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0048
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0014 0.0006 0.0018
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0011 0.001
Echinococcus multilocularis expressed protein 0.0034 0.0073 0.0071
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.002
Echinococcus granulosus dnaJ subfamily B 0.0428 0.1418 0.1417
Echinococcus multilocularis bloom syndrome protein 0.0047 0.0118 0.0116
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0027 0.0025
Plasmodium vivax steroid dehydrogenase, putative 0.0013 0.0002 0.0028
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0083 0.0157
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0111 0.1788
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1567 0.5299 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0015 0.0013
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0016 0.0134
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0044 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1567 0.5299 1
Brugia malayi Thioredoxin reductase 0.0184 0.0586 0.1289
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0022 0.0248
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0014 0.0006 0.0018
Mycobacterium ulcerans glutamate synthase subunit beta 0.0017 0.0016 0.0057
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0043 0.0079
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0181 0.0179
Trichomonas vaginalis DNA helicase recq1, putative 0.0047 0.0118 0.0219
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.006 0.0535
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0176 0.8178
Mycobacterium ulcerans hypothetical protein 0.0023 0.0038 0.0142
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0176 0.1614
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0014 0.0006 0.0005
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0633 0.2115 0.3989
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0362 0.068
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0044 0.0093
Entamoeba histolytica hypothetical protein 0.002 0.0027 0.0048
Plasmodium vivax SET domain protein, putative 0.0194 0.0619 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0765 0.2567 1
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0006 0.0009
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0075 0.0215 0.2584
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.0827 0.3216
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0111 0.0206
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0215 0.047
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.0628 0.0626
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0267 0.087 0.0869
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0176 0.1614
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.007 0.0636
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0158 0.1447
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0016 0.0015
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0063 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1567 0.5299 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.049 0.4522
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0056
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0014 0.0006 0.0055
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0128
Treponema pallidum oxidoreductase 0.0017 0.0016 0.0019
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0015 0.0013
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0016 0.0134
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0027 0.0025
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0014 0.0006 0.0042
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0024 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0048 0.0087
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0118
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0274 0.0601
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1567 0.5299 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0238 0.0769 0.2989
Loa Loa (eye worm) RecQ helicase 0.0047 0.0118 0.0255
Schistosoma mansoni regulator of G protein signaling 0.002 0.0027 0.0025
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0014 0.0006 0.0018
Leishmania major cytochrome p450-like protein 0.0031 0.0063 0.0565
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0083 0.0315
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0016 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Loa Loa (eye worm) hypothetical protein 0.0057 0.0152 0.0332
Leishmania major hypothetical protein, conserved 0.0017 0.0016 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0116 0.1062
Leishmania major DNA polymerase kappa, putative 0.0023 0.0038 0.0337
Onchocerca volvulus 0.0063 0.0173 0.0331
Entamoeba histolytica hypothetical protein 0.002 0.0027 0.0048
Schistosoma mansoni hypothetical protein 0.0054 0.0143 0.0141
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.0176 0.1614
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0017 0.0016 0.0681
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0129 0.0398 0.0397
Brugia malayi Cytochrome P450 family protein 0.0031 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0058 0.0156 0.034
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0061 0.0715
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.0421 0.3877
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0016 0.0015
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0014 0.0006 0.0018
Brugia malayi Cytochrome P450 family protein 0.0031 0.0066 0.0141
Trichomonas vaginalis mercuric reductase, putative 0.0064 0.0176 0.0329
Echinococcus granulosus L aminoadipate semialdehyde 0.0267 0.087 0.0869
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0476 0.0474
Schistosoma mansoni glutaminase 0.0286 0.0934 0.0933
Echinococcus granulosus glutamate synthase 0.0017 0.0016 0.0015
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0014 0.0006 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0044 0.0389
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0398 0.0875
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0054 0.0052
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0111 0.0206
Schistosoma mansoni cpg binding protein 0.0066 0.0185 0.0183
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0016 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0274 0.0514
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0188 0.0601 0.0599
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0047 0.0118 0.0257
Echinococcus multilocularis mitogen activated protein kinase 0.0118 0.0362 0.036
Onchocerca volvulus 0.0146 0.0457 0.0882
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0238 0.0769 0.2989
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0027 0.0056
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0016 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.042 0.1391 0.5414
Trichomonas vaginalis phosphofructokinase, putative 0.0238 0.0769 0.1448
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0064 0.0176 0.2845
Brugia malayi beta-NAC-like protein 0.0116 0.0354 0.0776
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0176 0.1614
Echinococcus multilocularis thioredoxin glutathione reductase 0.0185 0.0588 0.0587
Echinococcus multilocularis cpg binding protein 0.0066 0.0185 0.0183
Plasmodium vivax JmjC domain containing protein 0.0016 0.0015 0.0234
Mycobacterium ulcerans 6-phosphofructokinase 0.0238 0.0769 0.2989
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0765 0.2567 1
Trichomonas vaginalis phosphofructokinase, putative 0.0238 0.0769 0.1448
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0016 0.0134
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0215 0.0831
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1567 0.5299 1
Toxoplasma gondii phosphofructokinase PFKII 0.0064 0.0177 0.2129
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0017 0.0016 0.0057
Schistosoma mansoni 6-phosphofructokinase 0.0238 0.0769 0.0767
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0016 0.0015
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0064 0.0177 0.2129
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0024 0.0049
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0118 0.0362 0.3333
Echinococcus multilocularis glutamate synthase 0.0017 0.0016 0.0015
Brugia malayi 6-phosphofructokinase 0.0238 0.0769 0.1692
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0026 0.0024
Loa Loa (eye worm) POT family protein 0.009 0.0264 0.0578
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0194 0.0619 0.0617
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0036 0.0034
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0049 0.0104
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0064 0.0176 0.068
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0024 0.0042
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0027 0.0025
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0017 0.0016 0.0057
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0016 0.0027
Trypanosoma cruzi trypanothione reductase, putative 0.0184 0.0586 0.5412
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0014 0.0006 0.0042
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0027 0.0025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0188 0.0601 0.2335
Plasmodium vivax 6-phosphofructokinase, putative 0.0064 0.0177 0.2866
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0118 0.0362 0.3333
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0075 0.0215 0.0394
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0136 0.0421 0.0924
Echinococcus granulosus mitogen activated protein kinase 0.0118 0.0362 0.036
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0017 0.0016 0.0057
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0044 0.0079
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Brugia malayi M-phase phosphoprotein, mpp8 0.0106 0.032 0.0702
Schistosoma mansoni regulator of G protein signaling 0.002 0.0027 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0274 0.0514
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0017 0.0016 0.0057
Schistosoma mansoni hypothetical protein 0.0013 0.0004 0.0002
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0017 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.0267 0.087 0.1915
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0136 0.0421 0.0419
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0181 0.0179
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0255 0.0827 0.3216
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0016 0.0134
Mycobacterium tuberculosis Probable dehydrogenase 0.042 0.1391 0.5414
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0014 0.0006 0.0018
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0118 0.0362 0.3333
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.006 0.0989
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0188 0.0601 0.5545
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0083 0.0748
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0176 0.1614
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0014 0.0006 0.0055
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0094 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0028
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0129 0.0398 0.0397
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0177 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0158 0.1447
Toxoplasma gondii thioredoxin reductase 0.0184 0.0586 0.7087
Mycobacterium tuberculosis Probable reductase 0.042 0.1391 0.5414
Brugia malayi Pre-SET motif family protein 0.0194 0.0619 0.1361
Mycobacterium ulcerans ferredoxin reductase 0.0017 0.0016 0.0057
Echinococcus granulosus mitogen activated protein kinase 3 0.0118 0.0362 0.036
Echinococcus granulosus expressed protein 0.0034 0.0073 0.0071
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0215 0.047
Trypanosoma brucei unspecified product 0.0095 0.0284 0.2609
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.042 0.1391 0.5414
Onchocerca volvulus 0.0106 0.032 0.0616
Loa Loa (eye worm) hypothetical protein 0.0075 0.0215 0.047
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0044 0.0079
Brugia malayi SET domain containing protein 0.002 0.0028 0.0058
Echinococcus granulosus thioredoxin glutathione reductase 0.0185 0.0588 0.0587
Brugia malayi hypothetical protein 0.0127 0.0393 0.0863
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0044 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0028
Brugia malayi phosphofructokinase 0.0238 0.0769 0.1692
Entamoeba histolytica phosphofructokinase, putative 0.0238 0.0769 0.1448
Treponema pallidum fructose-bisphosphate aldolase 0.1567 0.5299 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0015 0.0013
Brugia malayi Pre-SET motif family protein 0.1343 0.4535 1
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0006 0.0042
Echinococcus multilocularis 6 phosphofructokinase 0.0238 0.0769 0.0767
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0027 0.0025
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0015 0.0013
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0098 0.1646
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0064 0.0176 0.2845
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0016 0.0027
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0014 0.0006 0.0018
Echinococcus granulosus dna polymerase kappa 0.0102 0.0306 0.0305
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0016 0.0032
Brugia malayi jmjC domain containing protein 0.0062 0.0168 0.0368
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.0461 0.046
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0168 0.0167
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0633 0.2115 0.3989
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0083 0.0157
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0038 0.0622
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0274 0.0514
Brugia malayi glutamate synthase 0.0017 0.0016 0.0032
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0006 0.0042
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0075 0.0215 1
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0014 0.0006 0.0018
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0188 0.0601 0.1321
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0027 0.0025
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0045 0.0096
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0118
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0006 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.1082 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0176 0.1614
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0027 0.0025
Toxoplasma gondii hypothetical protein 0.0053 0.014 0.1672
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0118 0.0362 0.3333
Loa Loa (eye worm) 6-phosphofructokinase 0.0238 0.0769 0.1692
Schistosoma mansoni pyruvate kinase 0.0036 0.0083 0.0081
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0016 0.0134
Schistosoma mansoni microtubule-associated protein tau 0.2946 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.009
Schistosoma mansoni intermediate filament proteins 0.0058 0.0156 0.0154
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0016 0.0057
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0065 0.0764
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0016 0.0015
Toxoplasma gondii NADPH-glutathione reductase 0.0064 0.0176 0.2113
Schistosoma mansoni regulator of G protein signaling 0.002 0.0027 0.0025
Brugia malayi hypothetical protein 0.002 0.0027 0.0056
Echinococcus multilocularis geminin 0.0523 0.174 0.1739
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0048 0.0087
Leishmania major DNA polymerase kappa, putative 0.0082 0.0238 0.2184
Mycobacterium ulcerans hypothetical protein 0.0017 0.0016 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Entamoeba histolytica thioredoxin reductase, putative 0.0017 0.0016 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1567 0.5299 1
Schistosoma mansoni transcription factor btf3 0.0116 0.0354 0.0352
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0014 0.0006 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0073 0.0135
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0014 0.0006 0.001
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0094 0.0279 0.0278
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0049
Schistosoma mansoni DNA polymerase eta 0.0075 0.0215 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0044 0.0079
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0027 0.0025
Plasmodium falciparum thioredoxin reductase 0.0184 0.0586 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0028
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0016 0.0027
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0098 0.0182
Trichomonas vaginalis glutathione reductase, putative 0.0064 0.0176 0.0329
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0026 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0176 0.1614
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0016 0.0176
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0024 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0158 0.1447
Entamoeba histolytica hypothetical protein 0.0075 0.0215 0.0402
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0215 0.1975
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0168 0.0167
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0014 0.0006 0.0009
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0016 0.0015
Onchocerca volvulus 0.0058 0.0156 0.0298
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0014 0.0006 0.0055
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0044 0.0042
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0044 0.0707
Trypanosoma cruzi transcription factor btf3, putative 0.0116 0.0354 0.3257
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0014 0.0006 0.0005
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0015 0.0013
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0015 0.0013
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0075 0.0215 0.0831
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0016 0.0134
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.006 0.0535
Echinococcus multilocularis pyruvate kinase 0.0029 0.0056 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0044 0.0719
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0016 0.0015
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0066 0.0141
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0048 0.0087
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0015 0.0013
Trichomonas vaginalis dullard protein, putative 0.0025 0.0044 0.0079
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0014 0.0006 0.0042
Loa Loa (eye worm) RGS-3 protein 0.002 0.0027 0.0056
Leishmania major hypothetical protein, conserved 0.003 0.006 0.0535
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0006 0.0009
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0016 0.0032
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0014 0.0006 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.006 0.0989
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0038 0.0441
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0038 0.0337
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0017 0.0016 0.0027
Onchocerca volvulus 0.0058 0.0156 0.0298
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0255 0.0827 0.0825
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0014 0.0006 0.0018
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0027 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0005
Echinococcus multilocularis lamin dm0 0.0058 0.0156 0.0154
Brugia malayi CXXC zinc finger family protein 0.0063 0.0173 0.0377
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0026 0.0221
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0083 0.0748
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0083 0.098
Trichomonas vaginalis DNA polymerase eta, putative 0.0102 0.0306 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0096
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0014 0.0006 0.0005
Echinococcus granulosus expressed protein 0.0391 0.1291 0.1289
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0064 0.0177 0.0323
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0125 0.0123
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0467 0.155 0.6037
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0194 0.0619 0.7483
Loa Loa (eye worm) phosphofructokinase 0.0238 0.0769 0.1692
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0016 0.0015
Entamoeba histolytica phosphofructokinase, putative 0.0238 0.0769 0.1448
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0014 0.0006 0.0055
Plasmodium vivax glutathione reductase, putative 0.0184 0.0586 0.9473
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0027 0.0025
Trypanosoma brucei DNA polymerase eta, putative 0.0075 0.0215 0.1975
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.006 0.0535
Brugia malayi mbt repeat family protein 0.0049 0.0125 0.0272
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.0306 0.1187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1567 0.5299 1
Giardia lamblia Kinase, CMGC MAPK 0.0118 0.0362 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0064 0.0176 0.1614
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0016 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0016 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0014 0.0006 0.0018
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0026 0.0093
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0014 0.0006 0.0018
Brugia malayi polk-prov protein 0.005 0.0129 0.0281
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0083 0.0178
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0125 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.0827 0.3216
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0044
Echinococcus multilocularis microtubule associated protein 2 0.2946 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.1082 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0027 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0176 0.1614
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0274 0.0514
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0014 0.0006 0.0018
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0215 0.0403
Schistosoma mansoni DNA helicase recq1 0.0019 0.0024 0.0022
Leishmania major DNA polymerase eta, putative 0.0075 0.0215 0.1975
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0032 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0177 0.0332
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0176 0.1614
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0064 0.0176 0.068
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0185 0.059 0.0589
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0014 0.0006 0.0009
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.0194 0.0619 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0017 0.0016 0.0681
Trichomonas vaginalis dullard protein, putative 0.0025 0.0044 0.0079
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.002
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0016 0.0176
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0064 0.0138
Trichomonas vaginalis set domain proteins, putative 0.1528 0.5167 0.9752
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0098 0.165
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0274 0.2521
Loa Loa (eye worm) hypothetical protein 0.0332 0.1091 0.2402
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1343 0.4535 1
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0014 0.0006 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0194 0.0619 0.0617
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0016 0.0027
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0083 0.0178
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.0238 0.092
Leishmania major hypothetical protein, conserved 0.0025 0.0044 0.0389
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0116 0.1062
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.049 0.4522
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0015 0.0218
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0006 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0255 0.0827 0.7637
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0111 0.0109
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0016 0.0248
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0016 0.0176
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0014 0.0006 0.0042
Schistosoma mansoni hypothetical protein 0.0523 0.174 0.1739
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0016 0.0027
Echinococcus multilocularis dna polymerase eta 0.0075 0.0215 0.0213
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0274 0.0272
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.002
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.007 0.013
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0136 0.0421 0.0791
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0016 0.0134
Trypanosoma brucei polo-like protein kinase 0.0093 0.0274 0.2521
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0238 0.0769 0.144
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0015 0.0013
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0272
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0026 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0117 0.0217
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0016 0.0027
Giardia lamblia Glutamate synthase 0.0017 0.0016 0.0027
Brugia malayi hypothetical protein 0.0146 0.0457 0.1005
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0038 0.0337
Schistosoma mansoni DNA helicase recq5 0.0019 0.0024 0.0022
Brugia malayi Aldehyde dehydrogenase protein 4 0.0014 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.001
Brugia malayi POT family protein 0.009 0.0264 0.0578
Giardia lamblia Alcohol dehydrogenase 0.0014 0.0006 0.0009
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0226 0.0224
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0014 0.0006 0.0005
Brugia malayi hypothetical protein 0.002 0.0027 0.0056
Toxoplasma gondii aldehyde dehydrogenase 0.0255 0.0827 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0027 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0176 0.1614
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0014 0.0006 0.0005
Brugia malayi intermediate filament protein 0.0058 0.0156 0.034
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0084 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0048
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0015 0.0154
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0014 0.0006 0.0005
Mycobacterium ulcerans glutaminase 0.0286 0.0934 0.3635
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0014 0.0006 0.001
Giardia lamblia DINP protein human, muc B family 0.0082 0.0238 0.0445
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0136 0.0421 0.0924
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.0115
Loa Loa (eye worm) acetyltransferase 0.0152 0.0476 0.1046
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0014 0.0006 0.0018
Echinococcus multilocularis expressed protein 0.0391 0.1291 0.1289
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0098 0.0182
Toxoplasma gondii 6-phosphofructokinase 0.0064 0.0177 0.2129
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0272
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0014 0.0006 0.0018
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0017 0.0016 0.0057
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0136 0.0421 0.0419
Schistosoma mansoni axis inhibition protein axin 0.002 0.0027 0.0025
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0075 0.0215 0.2584
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0118
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0111 0.132
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0014 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0043 0.0386
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0063 0.0238
Schistosoma mansoni kinase 0.0048 0.0121 0.0119
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0005
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0064 0.0176 0.1614
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0075 0.0215 0.0831
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0168 0.0167
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0026 0.1121
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0044 0.0042
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0016 0.0015
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0064 0.0176 0.2982
Trypanosoma brucei trypanothione reductase 0.0184 0.0586 0.5412
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0064 0.0176 0.068
Giardia lamblia Pyruvate kinase 0.0019 0.0022 0.0039
Giardia lamblia Fructose-bisphosphate aldolase 0.1567 0.5299 1
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0038 0.0337
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0016 0.0027
Brugia malayi Bloom's syndrome protein homolog 0.0047 0.0118 0.0255
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0011 0.0021
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0148 0.0146
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0107
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0043 0.0386
Brugia malayi jmjC domain containing protein 0.0065 0.0181 0.0395
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0024 0.0383
Leishmania major DNA polymerase eta, putative 0.0023 0.0038 0.0337
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0016 0.0027
Giardia lamblia Thioredoxin reductase 0.0017 0.0016 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0176 0.1614
Mycobacterium tuberculosis Putative ferredoxin reductase 0.042 0.1391 0.5414
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0177 0.0332
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0156 0.034
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0026 0.0045
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0176 0.1614
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0274 0.2521
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0362 0.068
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0016 0.0248
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.0421 0.3877
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0016 0.0027
Leishmania major DNA damage repair protein, putative 0.0023 0.0038 0.0337
Entamoeba histolytica disulphide oxidoreductase, putative 0.0017 0.0016 0.0027
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.049 0.4522
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0354 0.0664
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0083 0.0748
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0032 0.003
Trypanosoma cruzi transcription factor btf3, putative 0.0116 0.0354 0.3257
Schistosoma mansoni hypothetical protein 0.0014 0.0006 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0194 0.0619 0.0617
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0044 0.0707
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0011 0.001
Brugia malayi Cytochrome P450 family protein 0.0031 0.0063 0.0135
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0036 0.0034
Echinococcus granulosus Solute carrier family 22 5 0.1136 0.3832 0.3831
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0014 0.0006 0.0018
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0027 0.0056
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0274 0.2521
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0014 0.0006 0.0005
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0014 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0056
Giardia lamblia DNA damage repair protein 0.0023 0.0038 0.0069
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0181 0.0179
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0094 0.0279 0.0278
Brugia malayi aldehyde dehydrogenase 0.0014 0.0006 0.001
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0125 0.0123
Toxoplasma gondii NAC domain-containing protein 0.0116 0.0354 0.4265
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0064 0.0176 0.8045
Echinococcus multilocularis mitogen activated protein kinase 3 0.0118 0.0362 0.036
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0177 0.0332
Trichomonas vaginalis dullard protein, putative 0.0025 0.0044 0.0079
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0188 0.0601 0.2335
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0238 0.2184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0148 0.0322
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0044 0.0042
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0044 0.0042
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0064 0.0177 0.0332
Echinococcus granulosus transcription factor btf3 0.0116 0.0354 0.0352
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0016 0.0015
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0129 0.0398 0.0397
Schistosoma mansoni pyruvate kinase 0.0019 0.0022 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0398 0.0875
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0083 0.0178
Toxoplasma gondii exonuclease III APE 0.002 0.0026 0.029
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0125 0.0123
Mycobacterium tuberculosis Probable oxidoreductase 0.0467 0.155 0.6037
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0006 0.0042
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0027 0.0025
Echinococcus granulosus geminin 0.0523 0.174 0.1739
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0014 0.0006 0.0018
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0016 0.0263
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0017 0.0016 0.0027
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0038 0.0337
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0129 0.0398 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0117 0.0217
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0044 0.0509
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.0421 0.3877
Leishmania major phosphopantetheinyl transferase-like protein 0.0075 0.0215 0.1973
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0032 0.0066
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0125 0.0123
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0017 0.0016 0.0057
Giardia lamblia NADH oxidase lateral transfer candidate 0.0064 0.0176 0.0329
Trypanosoma brucei unspecified product 0.0052 0.0135 0.1237
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0027 0.0056
Treponema pallidum thioredoxin reductase (trxB) 0.0017 0.0016 0.0019
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0027 0.0048
Brugia malayi glutathione reductase 0.0184 0.0586 0.1289
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0017 0.0016 0.0027
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0238 0.0769 0.7099
Loa Loa (eye worm) ICD-1 protein 0.0116 0.0354 0.0776
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0014 0.0006 0.0213
Onchocerca volvulus 0.0206 0.066 0.1274
Schistosoma mansoni ap endonuclease 0.002 0.0026 0.0024
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0014 0.0006 0.0005
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0125 0.0123
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0028
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0022 0.035
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0064 0.0176 0.1614
Echinococcus granulosus axis inhibition protein axin 0.002 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0056
Schistosoma mansoni lamin 0.0058 0.0156 0.0154
Plasmodium falciparum glutathione reductase 0.0064 0.0176 0.2982
Echinococcus granulosus lamin dm0 0.0058 0.0156 0.0154
Schistosoma mansoni glutamate synthase 0.0017 0.0016 0.0015
Schistosoma mansoni regulator of G protein signaling 0.002 0.0027 0.0025
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0016 0.0032
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0016 0.0134
Echinococcus multilocularis lamin 0.0058 0.0156 0.0154
Loa Loa (eye worm) glutaminase 2 0.0286 0.0934 0.2057
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0177 0.0332
Leishmania major pyruvate kinase 0.0036 0.0083 0.0748
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0043 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0274 0.0514
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0017 0.0016 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.0306 0.1187
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0075 0.0215 0.0831
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0215 0.1973
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0006 0.0042
Leishmania major ATP-dependent phosphofructokinase 0.0238 0.0769 0.7099
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0178
Echinococcus granulosus cpg binding protein 0.0066 0.0185 0.0183
Schistosoma mansoni lamin 0.0058 0.0156 0.0154
Loa Loa (eye worm) MBCTL1 0.0056 0.0148 0.0322
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0049
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0188 0.0601 0.2335
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0002 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.0628 0.0626
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.042 0.1391 0.5414
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0044 0.0389
Leishmania major trypanothione reductase 0.0184 0.0586 0.5412
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0016 0.0134
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0156 0.034
Plasmodium falciparum glutathione reductase 0.0184 0.0586 1
Loa Loa (eye worm) glutaminase 0.0286 0.0934 0.2057
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.1418 0.1417
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0004 0.0002
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0075 0.0215 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0083 0.0178
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0027 0.0056
Schistosoma mansoni hypothetical protein 0.0017 0.0016 0.0015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0026 0.0053
Echinococcus granulosus 6 phosphofructokinase 0.0238 0.0769 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0048
Echinococcus granulosus pyruvate kinase 0.0036 0.0083 0.0081
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0148 0.0322
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0125 0.0272
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0038 0.0036
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0064 0.0176 0.068
Giardia lamblia Kinase, PLK 0.0093 0.0274 0.0514
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0116 0.1062
Echinococcus multilocularis pyruvate kinase 0.0036 0.0083 0.0081
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0014 0.0006 0.0018
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0118 0.0362 0.3333
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0064 0.0176 0.0174
Echinococcus multilocularis transcription factor btf3 0.0116 0.0354 0.0352
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0274 0.0514
Toxoplasma gondii histone lysine methyltransferase SET1 0.013 0.0401 0.4838
Onchocerca volvulus 0.0049 0.0125 0.0238
Onchocerca volvulus 0.0017 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0125 0.0272
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0014 0.0006 0.0018
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0274 0.0272
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0215 0.047
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0016 0.0134
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0026 0.0024
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0006 0.0042
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0045 0.0082
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0005
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0064 0.0177 0.3004
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0017 0.0016 0.0681
Echinococcus granulosus phd:f box containing protein 0.0016 0.0015 0.0013
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0064 0.0138
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0017 0.0016 0.0057
Echinococcus granulosus bloom syndrome protein 0.0047 0.0118 0.0116
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0118 0.0362 0.3333
Chlamydia trachomatis pyruvate kinase 0.0036 0.0083 0.334
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0765 0.2567 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0118 0.0362 0.4364
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0016 0.0027
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0064 0.0176 0.2982
Schistosoma mansoni glutamate synthase 0.0017 0.0016 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0238 0.0769 0.1448
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0038 0.0616
Onchocerca volvulus 0.0106 0.032 0.0616
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0026 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0095 0.0284 0.2609
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0064 0.0177 0.8111
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0274 0.0514
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0274 0.0272
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0476 0.1046
Schistosoma mansoni aldehyde dehydrogenase 0.0255 0.0827 0.0825
Echinococcus granulosus pyruvate kinase 0.0036 0.0083 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Echinococcus multilocularis pyruvate kinase 0.0036 0.0083 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0015 0.0154
Giardia lamblia Pyruvate kinase 0.0036 0.0083 0.0153
Echinococcus multilocularis dna polymerase kappa 0.0102 0.0306 0.0305
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0083 0.0157
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0148 0.0146
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0036 0.0034
Leishmania major hypothetical protein, conserved 0.0017 0.0016 0.0134
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0016 0.0248
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0024 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0362 0.036
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0015 0.0013
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0048 0.0087
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.006 0.0701
Trypanosoma brucei unspecified product 0.0052 0.0135 0.1237
Schistosoma mansoni cpg binding protein 0.0063 0.0173 0.0171
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0173 0.0377
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0184
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.2787 0.2786
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0063 0.0565
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0028
Schistosoma mansoni axis inhibition protein axin 0.002 0.0027 0.0025
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0064 0.0176 0.0174
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0014 0.0006 0.0018
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0006 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0038 0.0337
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0362 0.068
Trypanosoma brucei protein kinase, putative 0.0118 0.0362 0.3333
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0027 0.0056
Echinococcus multilocularis musashi 0.0058 0.0156 0.0154
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0156 0.034
Entamoeba histolytica hypothetical protein 0.002 0.0027 0.0048
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0025 0.0044
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0016 0.0057
Mycobacterium ulcerans NADH dehydrogenase 0.0017 0.0016 0.0057
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0048 0.0087
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0118 0.0362 0.3333
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0206 0.066 0.0658
Trypanosoma brucei transcription factor BTF3, putative 0.0116 0.0354 0.3257
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0116 0.1062
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.007 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0354 0.0664
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0038 0.0337
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0274 0.0527
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.055 0.2138
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0073 0.0157
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0027 0.0025
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.002
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0094 0.0279 0.0278
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0274 0.0514
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0184 0.0586 0.2279
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0063 0.0565
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0194 0.0619 0.0617
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0016 0.0176
Echinococcus multilocularis 0.0025 0.0044 0.0042
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0106 0.032 0.0702
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0148 0.0146
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0028
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0027 0.0025
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0016 0.0134
Plasmodium vivax thioredoxin reductase, putative 0.0184 0.0586 0.9473
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0107
Entamoeba histolytica hypothetical protein 0.0116 0.0354 0.0664
Echinococcus granulosus intermediate filament protein 0.0058 0.0156 0.0154
Loa Loa (eye worm) thioredoxin reductase 0.0184 0.0586 0.1289
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0013 0.0012
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0014 0.0006 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0038 0.0337
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0306 0.2819
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0136 0.0421 0.3877
Trypanosoma brucei mitochondrial DNA polymerase beta 0.033 0.1082 1
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Trichomonas vaginalis rotamase, putative 0.0033 0.007 0.013
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0006 0.0042
Trichomonas vaginalis helicase, putative 0.0014 0.0007 0.001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0215 0.0213
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0176 0.0558 0.1226
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0016 0.0134
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.0238 0.2184
Brugia malayi PXA domain containing protein 0.002 0.0027 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0111 0.132
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0048 0.0102
Entamoeba histolytica phosphofructokinase, putative 0.0238 0.0769 0.1448
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0056
Plasmodium falciparum thioredoxin reductase 0.0064 0.0176 0.2982
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0022 0.0038
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0016 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.042 0.1391 0.5414
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0015 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0215 0.0831
Loa Loa (eye worm) hypothetical protein 0.0194 0.0619 0.1361
Brugia malayi CHD4 protein 0.0016 0.0011 0.0021
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0017 0.0016 0.0057
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0016 0.0027
Echinococcus granulosus axis inhibition protein axin 0.002 0.0027 0.0025
Plasmodium vivax 6-phosphofructokinase, putative 0.0064 0.0177 0.2866
Entamoeba histolytica transcription factor BTF3, putative 0.0116 0.0354 0.0664
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0027 0.0025
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0064 0.0177 0.3004
Leishmania major pyruvate kinase 0.0036 0.0083 0.0748
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0063 0.0135
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0038 0.0337
Plasmodium falciparum basic transcription factor 3b, putative 0.0116 0.0354 0.6018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1567 0.5299 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0467 0.155 0.6037
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0027 0.0025
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0215 0.0213
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0017 0.0016 0.0057
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0016 0.0027
Echinococcus multilocularis L aminoadipate semialdehyde 0.0267 0.087 0.0869
Schistosoma mansoni hypothetical protein 0.0428 0.1418 0.1417
Echinococcus granulosus dna polymerase eta 0.0075 0.0215 0.0213
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0006 0.0042
Leishmania major mitochondrial DNA polymerase beta 0.033 0.1082 1
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0226 0.0224
Schistosoma mansoni cpg binding protein 0.0066 0.0185 0.0183
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0306 0.2819
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0177 0.0332
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0017 0.0016 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0306 0.2819
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0064 0.0176 0.2113
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0238 0.0769 0.7099
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0038 0.0337
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0151 0.1382
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0049 0.0047
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0014 0.0006 0.0018
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0125 0.0238
Trichomonas vaginalis phosphofructokinase, putative 0.0238 0.0769 0.1448
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0044 0.0079
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0083 0.0315
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.007 0.0636
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0016 0.0134
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0093
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0083 0.0315
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0083 0.1335
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0083 0.0178
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0148 0.0146
Treponema pallidum NADH oxidase 0.0064 0.0176 0.0321
Plasmodium falciparum pyruvate kinase 0.0036 0.0083 0.1383
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0016 0.0134
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0014 0.0006 0.0018
Echinococcus granulosus lamin 0.0058 0.0156 0.0154
Schistosoma mansoni pyruvate kinase 0.0036 0.0083 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0026 0.0045
Loa Loa (eye worm) 6-phosphofructokinase 0.0238 0.0769 0.1692
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0354 0.0664
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0255 0.0827 0.0825
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0064 0.0177 0.8111
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0125 0.0123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1567 0.5299 1
Leishmania major hypothetical protein, conserved 0.0017 0.0016 0.0134
Leishmania major NADH dehydrogenase, putative 0.0017 0.0016 0.0134
Loa Loa (eye worm) hypothetical protein 0.0146 0.0457 0.1005
Schistosoma mansoni rotamase 0.0034 0.0073 0.0071
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0016 0.0015
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0038 0.0337
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0063 0.0135
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0054 0.0052
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0032 0.0066
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0032 0.0066
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0026 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0362 0.068
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0215 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0048 0.0087
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0064 0.0177 0.0332
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0064 0.0176 0.0385
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0026 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1567 0.5299 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0129 0.1181
Mycobacterium ulcerans monoxygenase 0.0017 0.0016 0.0057
Brugia malayi 6-phosphofructokinase 0.0238 0.0769 0.1692
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0102 0.0306 0.0575
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0048 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0048 0.0087
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0015 0.0013
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0118 0.0362 0.0794
Plasmodium vivax basic transcription factor 3b, putative 0.0116 0.0354 0.5712
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0014 0.0006 0.0018
Brugia malayi PXA domain containing protein 0.002 0.0027 0.0056
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.0118
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0027 0.0025
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0014 0.0006 0.0042
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0032 0.003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0215 0.0213
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.007 0.0636
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0016 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.0827 0.3216
Schistosoma mansoni glutamate synthase 0.0017 0.0016 0.0015
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0267 0.087 0.1915
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0022 0.0359
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0129 0.0398 0.0397
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0026 0.0221
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0041
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0027 0.0056
Trichomonas vaginalis rotamase, putative 0.0034 0.0073 0.0135
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0027 0.0025
Loa Loa (eye worm) glutathione reductase 0.0184 0.0586 0.1289
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0004 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.006 0.0963
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0047 0.0118 0.0257
Mycobacterium ulcerans hypothetical protein 0.0174 0.055 0.2138
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0026 0.0221
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0181 0.0395
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0016 0.0134
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0028
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0073 0.0157
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0024 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0194 0.0619 0.0617
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0027 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0032 0.003
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0006 0.0005
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0188 0.0601 0.0599
Brugia malayi glutaminase DH11.1 0.0286 0.0934 0.2057
Trichomonas vaginalis glutaminase, putative 0.0286 0.0934 0.176
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0026 0.0409
Brugia malayi MAP kinase sur-1 0.0118 0.0362 0.0794
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0016 0.0015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0176 0.1614

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) > 0 % Compound was tested for inhibition of the rat passive cutaneous anaphylaxis(PCA) 1 hr after oral administration; >0<50 ChEMBL. 7205868
Inhibition (functional) > 0 % Compound was tested for inhibition of the rat passive cutaneous anaphylaxis(PCA) 3h after oral administration; >0<50 ChEMBL. 7205868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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