Detailed information for compound 312260

Basic information

Technical information
  • TDR Targets ID: 312260
  • Name: methyl 3-benzyl-7-methoxy-4-oxido-1-oxoquinox alin-1-ium-2-carboxylate
  • MW: 340.33 | Formula: C18H16N2O5
  • H donors: 0 H acceptors: 3 LogP: 1.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(Cc2ccccc2)[n+]([O-])c2c([n+]1[O-])cc(cc2)OC
  • InChi: 1S/C18H16N2O5/c1-24-13-8-9-14-15(11-13)20(23)17(18(21)25-2)16(19(14)22)10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3
  • InChiKey: DGYJBOLRACTYPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 3-benzyl-7-methoxy-4-oxido-1-oxo-quinoxalin-1-ium-2-carboxylate
  • 3-benzyl-7-methoxy-4-oxido-1-oxo-2-quinoxalin-1-iumcarboxylic acid methyl ester
  • methyl 7-methoxy-4-oxidanidyl-1-oxo-3-(phenylmethyl)quinoxalin-1-ium-2-carboxylate
  • 3-benzyl-1-keto-7-methoxy-4-oxido-quinoxalin-1-ium-2-carboxylic acid methyl ester
  • methyl 7-methoxy-4-oxido-1-oxo-3-(phenylmethyl)quinoxalin-1-ium-2-carboxylate
  • 7-methoxy-4-oxido-1-oxo-3-(phenylmethyl)-2-quinoxalin-1-iumcarboxylic acid methyl ester
  • 3-(benzyl)-1-keto-7-methoxy-4-oxido-quinoxalin-1-ium-2-carboxylic acid methyl ester
  • AIDS-220647
  • AIDS220647
  • 2-Quinoxalinecarboxylic acid, 7-methoxy-3-(phenylmethyl)-, methyl ester, 1,4-dioxide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0195 0.0427
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0195 0.0301
Echinococcus granulosus Sugar transporter ERD6 protein 0.001 0.0027 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000042717
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0095 0.0208
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Brugia malayi hypothetical protein 0.0008 0.0014 0.003
Mycobacterium ulcerans integral membrane transport protein 0.001 0.0027 0.009
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0567 0.4086 0.649
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0051 0.0166
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0051 0.1074
Brugia malayi Cytochrome P450 family protein 0.0012 0.0048 0.0106
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0105 0.0721 0.3422
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0227 0.1076
Onchocerca volvulus 0.001 0.0027 0.0027
Onchocerca volvulus 0.001 0.0027 0.0027
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0195 0.0427
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0027 0.013
Schistosoma mansoni carbonyl reductase 0.0008 0.0014 0.0014
Giardia lamblia Short-chain dehydrogenase, putative 0.0008 0.0014 0.0022
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0014 0.0044
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.0064
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0051 0.0815
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0051 0.024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Loa Loa (eye worm) ICD-1 protein 0.0071 0.0472 0.1034
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0761 0.1191
Echinococcus multilocularis lamin 0.0027 0.015 0.0137
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.001 0.0027 0.0046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Schistosoma mansoni pyruvate kinase 0.0033 0.0195 0.0195
Echinococcus multilocularis musashi 0.0027 0.015 0.0137
Schistosoma mansoni cpg binding protein 0.0029 0.017 0.017
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Echinococcus granulosus mitogen activated protein kinase 3 0.0105 0.0721 0.0709
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0051 0.024
Trypanosoma brucei trypanothione reductase 0.0037 0.0227 0.1076
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0008 0.0014 0.0044
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0567 0.4086 0.6486
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0195 0.035
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Schistosoma mansoni sugar transporter 0.001 0.0027 0.0027
Brugia malayi Thioredoxin reductase 0.0037 0.0227 0.0497
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0014 0.0064
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0047 0.0104
Trypanosoma brucei glucose transporter 2A 0.001 0.0027 0.013
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Schistosoma mansoni carbonyl reductase 0.0008 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0174 0.0269
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Trichomonas vaginalis sugar transport protein, putative 0.001 0.0027 0.0035
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0.0014 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0116 0.0799 0.1751
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Trypanosoma brucei glucose transporter, putative 0.001 0.0027 0.013
Trypanosoma brucei protein kinase, putative 0.0105 0.0721 0.3422
Mycobacterium ulcerans short-chain type oxidoreductase 0.0008 0.0014 0.0044
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0066
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0149 0.0707
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0014 0.0044
Echinococcus multilocularis transcription factor btf3 0.0071 0.0472 0.0459
Leishmania major DNA polymerase eta, putative 0.0019 0.0095 0.045
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.001 0.0027 0.009
Trypanosoma brucei glucose transporter, putative 0.001 0.0027 0.013
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0066
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0027 0.006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.0064
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0095 0.0129
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0195 0.0597
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0188
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0622 0.8625
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0269
Plasmodium vivax steroid dehydrogenase, putative 0.0008 0.0014 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0622 0.0622
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0472 0.0742
Onchocerca volvulus 0.001 0.0027 0.0027
Brugia malayi CXXC zinc finger family protein 0.0029 0.017 0.0372
Echinococcus granulosus lamin dm0 0.0027 0.015 0.0137
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trypanosoma cruzi transcription factor btf3, putative 0.0071 0.0472 0.2239
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0195 0.0925
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.0792 0.1735
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0027 0.0014
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0174 0.3696
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0384 0.5322
Plasmodium falciparum basic transcription factor 3b, putative 0.0071 0.0472 1
Schistosoma mansoni glucose transporter 0.001 0.0027 0.0027
Plasmodium falciparum thioredoxin reductase 0.0013 0.0051 0.1074
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0195 0.0597
Mycobacterium tuberculosis Probable reductase 0.0084 0.0572 0.1838
Schistosoma mansoni DNA helicase recq1 0.0009 0.0022 0.0022
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0014 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0048 0.0106
Echinococcus multilocularis cpg binding protein 0.0031 0.0182 0.0168
Brugia malayi Sugar transporter family protein 0.001 0.0027 0.006
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.001 0.0027 0.013
Giardia lamblia Kinase, CMGC MAPK 0.0105 0.0721 0.1147
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0195 0.0925
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.0064
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0051 0.0166
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0027 0.0014
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0035
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0043 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Onchocerca volvulus 0.001 0.0027 0.0027
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0406 0.1331
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0871 0.6292 1
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0014 0.003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0095 0.0081
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0047 0.0034
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0761 0.0748
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0174 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0095 0.045
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0135 0.0443
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0135 0.2862
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0975 0.4626
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.0792 0.3758
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0761 0.1667
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0022 0.0312
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0135 0.1873
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0195 0.035
Echinococcus granulosus Solute carrier family 22 5 0.1019 0.7368 0.7364
Mycobacterium ulcerans hypothetical protein 0.0156 0.109 0.3572
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0027 0.006
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0027 0.0014
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0027 0.006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0034 0.0021
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0105 0.0721 0.3422
Trypanosoma cruzi hexose transporter, putative 0.001 0.0027 0.013
Giardia lamblia Hexose transporter 0.001 0.0027 0.0044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0047 0.0034
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0105 0.0721 0.3422
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0174 0.2418
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0064 0.1029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0034 0.0021
Trypanosoma brucei glucose transporter, putative 0.001 0.0027 0.013
Plasmodium vivax basic transcription factor 3b, putative 0.0071 0.0472 0.7588
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.0064
Brugia malayi major facilitator superfamily protein 0.001 0.0027 0.006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Leishmania major short chain dehydrogenase, putative 0.0008 0.0014 0.0064
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.0064
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0014 0.0064
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.026 0.1232
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0761 0.361
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0051 0.0815
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0012 0.0012
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.0064
Brugia malayi 6-phosphofructokinase 0.011 0.0761 0.1667
Brugia malayi 6-phosphofructokinase 0.011 0.0761 0.1667
Leishmania major pyruvate kinase 0.0033 0.0195 0.0925
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0589 0.1291
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0022 0.0009
Leishmania major 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.0064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.064 0.2063
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0014 0.003
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0095 0.0311
Echinococcus multilocularis solute carrier family 22 0.001 0.0027 0.0014
Leishmania major hypothetical protein, conserved 0.0009 0.0024 0.0116
Trypanosoma brucei transcription factor BTF3, putative 0.0071 0.0472 0.2239
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0174 0.2804
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0105 0.0721 0.3422
Leishmania major glucose transporter, lmgt2 0.001 0.0027 0.013
Brugia malayi pyruvate kinase, muscle isozyme 0.0007 0.0007 0.0016
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0027 0.013
Schistosoma mansoni hypothetical protein 0.0012 0.0043 0.0043
Giardia lamblia Hypothetical protein 0.0008 0.0014 0.0022
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0079 0.1099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0871 0.6292 1
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0014 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0095 0.045
Leishmania major glucose transporter/membrane transporter D2, putative 0.001 0.0027 0.013
Loa Loa (eye worm) RecQ helicase 0.0022 0.0115 0.0252
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0227 0.3644
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0022 0.0049
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0022 0.0009
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0014 0.0064
Trypanosoma cruzi hexose transporter, putative 0.001 0.0027 0.013
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0761 0.1191
Brugia malayi oxidoreductase 0.0008 0.0014 0.003
Echinococcus granulosus bloom syndrome protein 0.0022 0.0115 0.0102
Onchocerca volvulus 0.001 0.0027 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0024 0.0116
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Leishmania major dehydrogenase-like protein 0.0008 0.0014 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000042717
Giardia lamblia Pyruvate kinase 0.0033 0.0195 0.031
Echinococcus multilocularis pyruvate kinase 0.0033 0.0195 0.0182
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0761 0.361
Plasmodium falciparum glutathione reductase 0.0013 0.0051 0.1074
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Schistosoma mansoni cpg binding protein 0.0031 0.0182 0.0182
Entamoeba histolytica hypothetical protein 0.0024 0.0135 0.0194
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0014 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0149 0.0707
Leishmania major short chain dehydrogenase, putative 0.0008 0.0014 0.0064
Leishmania major basic transcription factor 3a, putative 0.0071 0.0472 0.2239
Trypanosoma brucei glucose transporter, putative 0.001 0.0027 0.013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Mycobacterium ulcerans dehydrogenase 0.0008 0.0014 0.0044
Onchocerca volvulus 0.001 0.0027 0.0027
Trypanosoma brucei unspecified product 0.0019 0.0095 0.045
Onchocerca volvulus 0.001 0.0027 0.0027
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.0792 0.0792
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0472 0.0742
Schistosoma mansoni sugar transporter 0.001 0.0027 0.0027
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0406 0.0393
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0149 0.3155
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0014 0.0013
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0761 0.361
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000042717
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0052 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.0064
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Echinococcus multilocularis lamin dm0 0.0027 0.015 0.0137
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0135 0.0641
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.2108 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0188
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0761 0.0761
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Loa Loa (eye worm) pyruvate kinase 0.0007 0.0007 0.0016
Entamoeba histolytica hypothetical protein 0.0071 0.0472 0.073
Trypanosoma cruzi hexose transporter, putative 0.001 0.0027 0.013
Onchocerca volvulus 0.001 0.0027 0.0027
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0014 0.0064
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0014 0.0064
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0721 0.1139
Onchocerca volvulus 0.0027 0.015 0.0264
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0406 0.0406
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0227 0.0497
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0406 0.1331
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0014 0.0014
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0066
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0149 0.2065
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.0064
Echinococcus multilocularis dna polymerase eta 0.0019 0.0095 0.0081
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0051 0.0037
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0066
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0799 0.0787
Loa Loa (eye worm) dehydrogenase 0.0008 0.0014 0.003
Schistosoma mansoni DNA polymerase eta 0.0019 0.0095 0.0095
Schistosoma mansoni glucose transport protein 0.001 0.0027 0.0027
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.001 0.0027 0.0046
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.0064
Schistosoma mansoni intermediate filament proteins 0.0027 0.015 0.015
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0014 0.0044
Brugia malayi Pre-SET motif family protein 0.0633 0.4565 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Toxoplasma gondii facilitative glucose transporter GT1 0.001 0.0027 0.0381
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Echinococcus multilocularis solute carrier family 22 0.001 0.0027 0.0014
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0195 0.0925
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0022 0.0312
Plasmodium vivax SET domain protein, putative 0.0091 0.0622 1
Chlamydia trachomatis pyruvate kinase 0.0033 0.0195 1
Onchocerca volvulus 0.001 0.0027 0.0027
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Trypanosoma cruzi transcription factor btf3, putative 0.0071 0.0472 0.2239
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Brugia malayi Sugar transporter family protein 0.001 0.0027 0.006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0135 0.5853
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0406 0.0406
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0008 0.0014 0.0064
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0042 0.0197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000042717
Trypanosoma brucei glucose transporter 1E 0.001 0.0027 0.013
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Onchocerca volvulus 0.001 0.0027 0.0027
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0079 0.1274
Schistosoma mansoni transcription factor btf3 0.0071 0.0472 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0871 0.6292 1
Trypanosoma brucei glucose transporter, putative 0.001 0.0027 0.013
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0027 0.0014
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0014 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0095 0.0311
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0174 0.8583
Brugia malayi hypothetical protein 0.0017 0.0081 0.0178
Loa Loa (eye worm) hypothetical protein 0.0013 0.0051 0.0111
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.0064
Echinococcus multilocularis solute carrier family 22 0.001 0.0027 0.0014
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0034 0.0021
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0105 0.0721 0.3422
Echinococcus multilocularis pyruvate kinase 0.0033 0.0195 0.0182
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0.0014 0.0188
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0048 0.0106
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0572 0.1838
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.0064
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0014 0.0044
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0042 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0095 0.0208
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0022 0.0009
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0027 0.0014
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.023 0.0217
Onchocerca volvulus 0.001 0.0027 0.0027
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0115 0.0252
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0406 0.5632
Trypanosoma cruzi sugar transporter, putative 0.001 0.0027 0.013
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0008 0.0014 0.0044
Mycobacterium ulcerans carveol-like dehydrogenase 0.0008 0.0014 0.0044
Echinococcus granulosus geminin 0.0167 0.117 0.1158
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma brucei unspecified product 0.0013 0.0052 0.0247
Plasmodium falciparum steroid dehydrogenase, putative 0.0008 0.0014 0.0287
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0051 0.0037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0051 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0014 0.0044
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0008 0.0014 0.0044
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0051 0.024
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0014 0.0064
Schistosoma mansoni DNA helicase recq5 0.0009 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.0012 0.0048 0.0106
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.064 0.2063
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0095 0.0208
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0048 0.0106
Plasmodium falciparum pyruvate kinase 0.0033 0.0195 0.4128
Echinococcus granulosus lamin 0.0027 0.015 0.0137
Echinococcus granulosus solute carrier family 22 0.001 0.0027 0.0014
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0095 0.0081
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0008 0.0014 0.0287
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0046 0.0102
Schistosoma mansoni hypothetical protein 0.0167 0.117 0.117
Leishmania major pteridine reductase 1 0.0008 0.0014 0.0064
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.001 0.0027 0.0014
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.026 0.1232
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.026 0.1232
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0014 0.0064
Echinococcus granulosus pyruvate kinase 0.0033 0.0195 0.0182
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.001 0.0027 0.0582
Echinococcus granulosus synaptic vesicle 2 protein 0.001 0.0027 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0095 0.0267
Plasmodium vivax sugar transporter, putative 0.001 0.0027 0.0442
Giardia lamblia Pyruvate kinase 0.0017 0.0079 0.0126
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0227 0.0702
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0048 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0326
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0593 0.0581
Leishmania major hypothetical protein, conserved 0.0026 0.0149 0.0707
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0048 0.0158
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0195 0.0301
Schistosoma mansoni lamin 0.0027 0.015 0.015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0095 0.0267
Toxoplasma gondii hypothetical protein 0.0048 0.0304 0.4217
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0034 0.0021
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0014 0.003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0195 0.0427
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0034 0.0034
Echinococcus granulosus solute carrier family 22 0.001 0.0027 0.0014
Onchocerca volvulus 0.001 0.0027 0.0027
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.015 0.0329
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0066
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0051 0.0166
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0188
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0014 0.003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0051 0.3056
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0035
Leishmania major DNA polymerase kappa, putative 0.0019 0.0095 0.045
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0014 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0051 0.024
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0051 0.024
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0095 0.0095
Echinococcus multilocularis synaptic vesicle 2 protein 0.001 0.0027 0.0014
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0105 0.0721 0.3422
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0095 0.045
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0.0014 0.0188
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0174 0.0277
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0095 0.0142
Echinococcus granulosus intermediate filament protein 0.0027 0.015 0.0137
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0029 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.0208
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0792 0.2596
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.0736 0.1612
Mycobacterium ulcerans oxidoreductase 0.0008 0.0014 0.0044
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0014 0.0064
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0135 0.1873
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0014 0.0064
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0572 0.1838
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0051 0.0072
Loa Loa (eye worm) phosphofructokinase 0.011 0.0761 0.1667
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0975 0.4626
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0572 0.1838
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.064 0.2063
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0027 0.006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0975 0.4626
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0174 0.0198
Loa Loa (eye worm) hypothetical protein 0.0087 0.0589 0.1291
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0572 0.1838
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.0064
Toxoplasma gondii sugar transporter ST1 0.001 0.0027 0.0381
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.017 0.0372
Schistosoma mansoni cpg binding protein 0.0031 0.0182 0.0182
Echinococcus granulosus dna polymerase eta 0.0019 0.0095 0.0081
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0116 0.0799 0.0799
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0195 0.2702
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0027 0.0014
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0115 0.0102
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0116 0.0799 0.1751
Brugia malayi Pre-SET motif family protein 0.0091 0.0622 0.1363
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0051 0.024
Entamoeba histolytica transcription factor BTF3, putative 0.0071 0.0472 0.073
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0721 0.0721
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0105 0.0721 0.158
Onchocerca volvulus 0.0721 0.5201 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0871 0.6292 1
Echinococcus multilocularis mitogen activated protein kinase 0.0105 0.0721 0.0709
Brugia malayi pyruvate kinase 0.0007 0.0007 0.0016
Echinococcus granulosus solute carrier family 22 0.001 0.0027 0.0014
Plasmodium falciparum glutathione reductase 0.0037 0.0227 0.4803
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0799 0.0787
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0761 0.2494
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0406 0.1927
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0095 0.045
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0014 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0761 0.1202
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0195 0.035
Leishmania major oxidoreductase-like protein 0.0008 0.0014 0.0064
Onchocerca volvulus 0.0027 0.015 0.0264
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0014 0.0013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.026 0.1232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000042717
Schistosoma mansoni lamin 0.0027 0.015 0.015
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0051 0.024
Onchocerca volvulus 0.001 0.0027 0.0027
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0622 0.0609
Trichomonas vaginalis glucose transporter, putative 0.001 0.0027 0.0035
Leishmania major trypanothione reductase 0.0037 0.0227 0.1076
Treponema pallidum fructose-bisphosphate aldolase 0.0871 0.6292 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0174 0.0269
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0014 0.003
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0149 0.0707
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.0064
Leishmania major myo-inositol/proton symporter (MIT) 0.001 0.0027 0.013
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0014 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2108 1
Mycobacterium ulcerans dehydrogenase/reductase 0.0008 0.0014 0.0044
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0095 0.0142
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0027 0.006
Trichomonas vaginalis glucose transporter, putative 0.001 0.0027 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Brugia malayi POT family protein 0.008 0.0541 0.1186
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.0064
Echinococcus granulosus cpg binding protein 0.0031 0.0182 0.0168
Plasmodium vivax hexose transporter 0.001 0.0027 0.0442
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0008 0.0014 0.0064
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0135 0.0135
Onchocerca volvulus 0.0029 0.017 0.0301
Echinococcus multilocularis solute carrier family 22 0.001 0.0027 0.0014
Schistosoma mansoni pyruvate kinase 0.0033 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0329
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0622 0.0622
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0135 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0425 0.3052 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Echinococcus granulosus transcription factor btf3 0.0071 0.0472 0.0459
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0051 0.0703
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0174 0.0269
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0051 0.3056
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0095 0.045
Trypanosoma brucei unspecified product 0.0013 0.0052 0.0247
Schistosoma mansoni carbonyl reductase 0.0008 0.0014 0.0014
Schistosoma mansoni microtubule-associated protein tau 0.138 1 1
Brugia malayi Sugar transporter family protein 0.001 0.0027 0.006
Mycobacterium ulcerans sugar transporter 0.001 0.0027 0.009
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0761 0.1667
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Leishmania major cytochrome p450-like protein 0.0012 0.0048 0.0229
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0195 0.0639
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0051 0.024
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.0792 0.2563
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Brugia malayi hypothetical protein 0.001 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0048
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0051 0.024
Trypanosoma brucei oxidoreductase-like protein 0.0008 0.0014 0.0064
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0051 0.0111
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0026 0.0057
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0761 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0052 0.0247
Trypanosoma brucei glucose transporter, putative 0.001 0.0027 0.013
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Loa Loa (eye worm) sugar transporter 0.001 0.0027 0.006
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0027 0.013
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0572 0.1838
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0721 0.1139
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0622 0.0609
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0721 0.1139
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0042 0.0197
Echinococcus multilocularis geminin 0.0167 0.117 0.1158
Brugia malayi hypothetical protein 0.001 0.0027 0.006
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0799 0.0787
Giardia lamblia DINP protein human, muc B family 0.0019 0.0095 0.0151
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0022 0.0049
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0174 0.3696
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0027 0.0014
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0051 0.024
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0051 0.0072
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0135 0.2171
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0135 0.04
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0008 0.0014 0.0044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0051 0.024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0061 0.0133
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0079 0.1679
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Schistosoma mansoni glucose transport protein 0.001 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.001 0.0027 0.0027
Trypanosoma cruzi glucose transporter, putative 0.001 0.0027 0.013
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.0064
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0014 0.0064
Brugia malayi major facilitator superfamily protein 0.001 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0174 0.0269
Leishmania major hypothetical protein, conserved 0.001 0.0027 0.013
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0115 0.0174
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0014 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0005 0.000000000042717
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0195 0.0427
Brugia malayi hypothetical protein 0.001 0.0027 0.006
Onchocerca volvulus 0.0091 0.0622 0.1173
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0188
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0589 0.0577
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0051 0.024
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0115 0.0174
Trypanosoma brucei glucose transporter, putative 0.001 0.0027 0.013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0095 0.045
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.0064
Brugia malayi hypothetical protein 0.0026 0.0149 0.0326
Trypanosoma brucei sugar transporter, putative 0.001 0.0027 0.013
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0633 0.4565 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0622 0.0609
Loa Loa (eye worm) intermediate filament protein 0.0027 0.015 0.0329
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0792 0.078
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0014 0.0188
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trichomonas vaginalis myo-inositol transporter, putative 0.001 0.0027 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0871 0.6292 1
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0008 0.0014 0.0064
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0048 0.0229
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.0188
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0061 0.0133
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0174 0.0269
Toxoplasma gondii thioredoxin reductase 0.0037 0.0227 0.3143
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0174 0.2804
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0871 0.6292 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0043 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Leishmania major glucose transporter, lmgt1 0.001 0.0027 0.013
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0135 0.0443
Brugia malayi intermediate filament protein 0.0027 0.015 0.0329
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0792 0.2596
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0051 0.1074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Echinococcus multilocularis microtubule associated protein 2 0.138 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0761 0.1202
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0022 0.0049
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0042 0.0197
Echinococcus multilocularis Sugar transporter ERD6 protein 0.001 0.0027 0.0014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0095 0.0095
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Leishmania major pyruvate kinase 0.0033 0.0195 0.0925
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0014 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0174 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0472 0.0742
Trypanosoma brucei glucose transporter, putative 0.001 0.0027 0.013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0105 0.0721 0.3422
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0326 0.1546
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0051 0.0703
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0195 0.0925
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0149 0.2394
Trypanosoma cruzi hexose transporter 0.001 0.0027 0.013
Schistosoma mansoni hypothetical protein 0.0167 0.117 0.117
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0792 0.078
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0014 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0051 0.0081
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Loa Loa (eye worm) dehydrogenase 0.0008 0.0014 0.003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Toxoplasma gondii sugar transporter ST2 0.001 0.0027 0.0381
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.0064
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0761 0.1191
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.2108 1
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0123 0.0174
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0022 0.0009
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0135 0.0641
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0005 0.000000000042717
Schistosoma mansoni glucose transport protein 0.001 0.0027 0.0027
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0026 0.0057
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0022 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0406 0.1331
Onchocerca volvulus 0.001 0.0027 0.0027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0051 0.024
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0014 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0014 0.0064
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0195 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0035
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.001 0.0027 0.009
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.001 0.0027 0.0027
Trichomonas vaginalis set domain proteins, putative 0.0721 0.5201 0.8264
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.0064
Plasmodium falciparum hexose transporter 0.001 0.0027 0.0582
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0063 0.087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0083 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0035
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0014 0.0013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0051 0.024
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0761 0.1202
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0051 0.0051
Echinococcus granulosus dna polymerase kappa 0.0019 0.0095 0.0081
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.064 0.2063
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0761 0.1138
Trichomonas vaginalis glucose transporter, putative 0.001 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0091 0.0622 0.1363
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0425 0.3052 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0123 0.0269
Echinococcus granulosus solute carrier family 22 0.001 0.0027 0.0014
Mycobacterium ulcerans oxidoreductase 0.0008 0.0014 0.0044
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2108 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0227 0.4803
Onchocerca volvulus 0.001 0.0027 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.109 0.3544
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.0064
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0042 0.0045
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0014 0.0044
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0761 0.0761
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0051 0.0122
Onchocerca volvulus 0.0087 0.0589 0.111
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0096 0.2033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0103
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0024 0.0116
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0014 0.0064
Loa Loa (eye worm) POT family protein 0.008 0.0541 0.1186
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Toxoplasma gondii sugar transporter ST3 0.001 0.0027 0.0381
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0871 0.6292 1
Loa Loa (eye worm) sugar transporter 0.001 0.0027 0.006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0174 0.8583
Giardia lamblia Fructose-bisphosphate aldolase 0.0871 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.006
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0095 0.045
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0035
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0406 0.1293
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0014 0.003
Leishmania major glucose transporter, lmgt3 0.001 0.0027 0.013
Brugia malayi glutathione reductase 0.0037 0.0227 0.0497
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0051 0.0037
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0051 0.024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0048 0.0229
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.023 0.0217
Schistosoma mansoni sugar transporter 0.001 0.0027 0.0027
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Toxoplasma gondii transporter, major facilitator family protein 0.001 0.0027 0.0381
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Brugia malayi beta-NAC-like protein 0.0071 0.0472 0.1034
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0761 0.246
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0761 0.1202
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0014 0.0064
Schistosoma mansoni sugar transporter 0.001 0.0027 0.0027
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0014 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.000000000042717
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Toxoplasma gondii NAC domain-containing protein 0.0071 0.0472 0.6544
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0014 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0871 0.6292 1
Onchocerca volvulus Putative transporter 0.001 0.0027 0.0027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0014 0.003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0035
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0051 0.0037
Onchocerca volvulus 0.001 0.0027 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0052 0.0247
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0174 0.2418
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0014 0.0014
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Loa Loa (eye worm) oxidoreductase 0.0008 0.0014 0.003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0027 0.0035
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0008 0.0014 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0871 0.6292 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0105 0.0721 0.0709
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0149 0.3155
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0014 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0622 0.0622
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0022 0.0476
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0095 0.045
Leishmania major short chain dehydrogenase-like protein 0.0008 0.0014 0.0064
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0.0014 0.0188
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0572 0.1838
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Trypanosoma cruzi hexose transporter, putative 0.001 0.0027 0.013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Echinococcus multilocularis pyruvate kinase 0.0026 0.0145 0.0131
Giardia lamblia Sugar-proton symporter 0.001 0.0027 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0622 0.0622
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Plasmodium vivax glutathione reductase, putative 0.0037 0.0227 0.3644
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0105 0.0721 1
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0014 0.0064
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0406 0.0393
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.0427
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0.0014 0.0188
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.001 0.0027 0.1146
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0195 0.3132
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0095 0.045
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0174 0.2418
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0008 0.0014 0.0287
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0174 0.0269
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0589 0.0577
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0095 0.045
Echinococcus granulosus pyruvate kinase 0.0033 0.0195 0.0182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0051 0.024
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0799 0.0787
Echinococcus granulosus mitogen activated protein kinase 0.0105 0.0721 0.0709
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0014 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0721 0.1139
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0432 0.0432
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0014 0.0044
Loa Loa (eye worm) glutathione reductase 0.0037 0.0227 0.0497
Trichomonas vaginalis sugar transporter, putative 0.001 0.0027 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0014 0.0218
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.015 0.0329
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0589 0.0589
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0095 0.0081
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0014 0.0188
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0082 0.0082
Brugia malayi phosphofructokinase 0.011 0.0761 0.1667
Giardia lamblia Reductase, putative 0.0008 0.0014 0.0022
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0135 0.04
Schistosoma mansoni pyruvate kinase 0.0017 0.0079 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0871 0.6292 1
Brugia malayi hypothetical protein 0.0008 0.0014 0.003
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0425 0.3052 1
Brugia malayi MAP kinase sur-1 0.0105 0.0721 0.158
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0761 0.246
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0095 0.045

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) > 62.5 ug ml-1 Compound was tested for cytotoxicity in Vero cells ChEMBL. 15771444
MIC (functional) = 0.78 ug ml-1 In vitro actual minimum inhibitoryconcentration value of thecompound was determined againstMycobacterium tuberculosis ChEMBL. 15771444
MIC (functional) = 0.78 ug ml-1 In vitro actual minimum inhibitoryconcentration value of thecompound was determined againstMycobacterium tuberculosis ChEMBL. 15771444
SI (ADMET) > 80.1 ug ml-1 Selectivity index (ratio of IC50 and MIC) value of the compound was determined ChEMBL. 15771444

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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