Detailed information for compound 400474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1129.3 | Formula: C54H84N10O16
  • H donors: 14 H acceptors: 18 LogP: 1.58 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 4
  • SMILES: N#CCN(CC[C@H]([C@@H]1NC(=O)[C@@H](NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)[C@H](C[C@H]([C@H](NC(=O)[C@H]2N(C1=O)CC[C@@H]2O)O)O)NC(=O)CCCCCCCCC(CC(CC)C)C)[C@H](O)C)O)[C@@H]([C@H](c1ccc(cc1)O)O)O)O)CC#N
  • InChi: 1S/C54H84N10O16/c1-5-30(2)26-31(3)12-10-8-6-7-9-11-13-41(71)57-36-28-40(70)50(76)61-52(78)45-39(69)19-23-63(45)54(80)43(38(68)18-22-62(24-20-55)25-21-56)59-51(77)44(47(73)46(72)33-14-16-34(66)17-15-33)60-49(75)37-27-35(67)29-64(37)53(79)42(32(4)65)58-48(36)74/h14-17,30-32,35-40,42-47,50,65-70,72-73,76H,5-13,18-19,22-29H2,1-4H3,(H,57,71)(H,58,74)(H,59,77)(H,60,75)(H,61,78)/t30?,31?,32-,35-,36+,37+,38-,39+,40-,42+,43+,44+,45+,46+,47+,50-/m1/s1
  • InChiKey: ZPAHMPZEUHFWRJ-ZELNKJOMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae FKS3 (YMR306W) 1,3-beta glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans N terminus of glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans C terminus of glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Toxoplasma gondii 1,3-beta-glucan synthase component protein Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans N terminus of glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
Neospora caninum hypothetical protein Get druggable targets OG5_127693 All targets in OG5_127693
Candida albicans C terminus of glucan synthase Get druggable targets OG5_127693 All targets in OG5_127693
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0334 0.0587
Echinococcus granulosus g protein coupled receptor 0.0011 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0011 0.0019 0.0026
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0314 0.0314
Brugia malayi beta-lactamase family protein 0.0042 0.0334 0.0334
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0019 0.0019
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0019 0.0019
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0019 0.0019
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.039 0.61
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.0334
Mycobacterium leprae Conserved hypothetical protein 0.0037 0.0284 0.6914
Toxoplasma gondii cell division protein CDC48AP 0.0017 0.0077 0.0302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0011 0.0019 0.0026
Schistosoma mansoni hypothetical protein 0.0068 0.0608 0.0835
Echinococcus granulosus g protein coupled receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0019 0.0019
Echinococcus granulosus neuropeptide receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0019 0.0019
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0314 0.2886
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0229 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1649 0.3047
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0019 0.0019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0334 0.0334
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0019 0.0019
Onchocerca volvulus 0.0042 0.0334 0.0622
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0046 0.0046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0019 0.0019
Echinococcus multilocularis lamin dm0 0.0028 0.0197 0.0197
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0037 0.0284 0.2594
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0019 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0037 0.0284 0.098
Schistosoma mansoni adenoreceptor 0.0011 0.0019 0.0026
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0499 0.0499
Echinococcus granulosus lamin 0.0028 0.0197 0.0197
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0037 0.0284 0.5249
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Schistosoma mansoni zinc finger protein 0.0025 0.0159 0.0218
Onchocerca volvulus 0.0199 0.1963 0.3657
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0267 0.4875
Entamoeba histolytica hypothetical protein 0.0036 0.0274 0.4186
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0542 0.0542
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0037 0.0284 0.5249
Schistosoma mansoni cytochrome P450 0.0037 0.0284 0.039
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0037 0.0284 0.098
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0019 0.0019
Onchocerca volvulus 0.0011 0.0019 0.0035
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0028 0.0194 0.0267
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.1038 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Brugia malayi hypothetical protein 0.0062 0.0542 0.0542
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0334 0.117
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0334 0.0458
Loa Loa (eye worm) hypothetical protein 0.0076 0.0688 0.0688
Echinococcus granulosus snurportin 1 0.0635 0.6493 0.6493
Echinococcus granulosus zinc finger protein 0.0025 0.0159 0.0159
Onchocerca volvulus 0.0066 0.0592 0.1102
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1649 0.3073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0037 0.0284 0.5249
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2564 0.4759
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0019 0.0019
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0037 0.0284 0.2398
Loa Loa (eye worm) CYP4Cod1 0.0045 0.0375 0.0375
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0017 0.0077 0.0302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0037 0.0284 0.098
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Trypanosoma cruzi ISWI complex protein 0.0016 0.0073 0.0271
Onchocerca volvulus 0.0062 0.0542 0.101
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0357 0.0357
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0037 0.0284 0.098
Loa Loa (eye worm) hypothetical protein 0.0049 0.0415 0.0415
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.052 0.4917
Onchocerca volvulus 0.0011 0.0019 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.045 0.0618
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.039 0.7592
Echinococcus multilocularis somatostatin receptor 0.0011 0.0019 0.0019
Brugia malayi PHD-finger family protein 0.003 0.0218 0.0218
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0274 0.0376
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0046 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0334 0.0334
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.039 0.7592
Loa Loa (eye worm) hypothetical protein 0.0028 0.0197 0.0197
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.002 0.0077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0046 0.0046
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0132 0.0132
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0046 0.0046
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0314 0.2698
Echinococcus multilocularis sex peptide receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0019 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.045 0.045
Echinococcus granulosus orexin receptor type 2 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0037 0.0284 0.098
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1649 0.3047
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0046 0.0046
Echinococcus multilocularis transportin 1 0.0011 0.002 0.002
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0046 0.0076
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0037 0.0284 0.5249
Entamoeba histolytica transcription factor BTF3, putative 0.007 0.0627 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.0334
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0019 0.0019
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0046 0.0063
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0019 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.039 0.3636
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0499 0.0499
Brugia malayi G-protein coupled receptor 0.0011 0.0019 0.0019
Echinococcus granulosus RUN 0.0062 0.0542 0.0542
Echinococcus multilocularis survival motor neuron protein 1 0.0973 1 1
Entamoeba histolytica cdc48-like protein, putative 0.0027 0.0179 0.263
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0019 0.0019
Echinococcus granulosus intermediate filament protein 0.0028 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Onchocerca volvulus 0.0011 0.0019 0.0035
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0314 0.0314
Echinococcus granulosus transcription factor btf3 0.007 0.0627 0.0627
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2564 0.4759
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1649 0.3047
Brugia malayi larval opioid receptor 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0247 0.084
Plasmodium vivax basic transcription factor 3b, putative 0.007 0.0627 1
Brugia malayi ORL1-like opioid receptor 0.0011 0.0019 0.0019
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0037 0.0284 0.098
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0138 0.0138
Schistosoma mansoni importin-beta 2 0.0011 0.002 0.0027
Toxoplasma gondii ABC1 family protein 0.0042 0.0334 0.1304
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.039 0.1384
Schistosoma mansoni importin beta-1 0.0059 0.052 0.0714
Leishmania major GTP-binding protein, putative 0.0044 0.0357 0.3316
Schistosoma mansoni myosin xvIII 0.0011 0.0019 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0019 0.0019
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0019 0.0026
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0019 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0334 0.2902
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0037 0.0284 0.098
Echinococcus granulosus translational activator gcn1 0.0011 0.002 0.002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0046 0.018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0019 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0019 0.0026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0357 0.1396
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0404 0.0718
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0037 0.0284 0.5249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0011 0.0019 0.0026
Brugia malayi putative neuropeptide receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.2655 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0037 0.0284 0.5249
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0019 0.0026
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0499 0.4708
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Mycobacterium ulcerans hypothetical protein 0.0047 0.039 0.7592
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.039 0.7592
Mycobacterium tuberculosis Putative conserved ATPase 0.0017 0.0077 0.0195
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0037 0.0284 0.098
Echinococcus multilocularis transcription factor btf3 0.007 0.0627 0.0627
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0019 0.0019
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0314 0.0314
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0153 0.021
Onchocerca volvulus 0.0028 0.0197 0.0368
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0046 0.0076
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0046 0.0076
Echinococcus granulosus g protein coupled receptor 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0037 0.0284 0.098
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0302 0.0302
Schistosoma mansoni neuropeptide receptor 0.0011 0.0019 0.0026
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0019 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0037 0.0284 0.098
Brugia malayi Serotonin receptor 0.0011 0.0019 0.0019
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0046 0.0606
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0046 0.018
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.0334
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0037 0.0284 0.5249
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0229 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0334 0.117
Onchocerca volvulus 0.0011 0.0019 0.0035
Leishmania major cytochrome p450-like protein 0.0037 0.0284 0.2594
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0028 0.0194 0.0194
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0238 0.2376 0.2376
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0019 0.0026
Echinococcus granulosus importin subunit beta 1 0.0059 0.052 0.052
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0027 0.0179 0.2764
Onchocerca volvulus 0.0011 0.0019 0.0035
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0037 0.0284 0.5249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0019 0.0026
Echinococcus granulosus cytochrome P450 2K1 0.0037 0.0284 0.0284
Schistosoma mansoni opsin-like receptor 0.0011 0.0019 0.0026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0019 0.0026
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0109 0.1038 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0247 0.084
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0037 0.0284 0.5249
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0329 0.5102
Schistosoma mansoni hypothetical protein 0.0712 0.7286 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0109 0.1038 1
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0046 0.0258
Brugia malayi beta-lactamase 0.0042 0.0334 0.0334
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0357 0.0357
Entamoeba histolytica hypothetical protein 0.0036 0.0274 0.4186
Schistosoma mansoni amine GPCR 0.0011 0.0019 0.0026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0334 0.117
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0019 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0229 0.0229
Loa Loa (eye worm) acetyltransferase 0.0155 0.1511 0.1511
Entamoeba histolytica hypothetical protein 0.0036 0.0274 0.4186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0092 0.0092
Brugia malayi G protein-coupled receptor 0.0011 0.0019 0.0019
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0019 0.0019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0229 0.0229
Onchocerca volvulus 0.0011 0.0019 0.0035
Echinococcus multilocularis snurportin 1 0.0635 0.6493 0.6493
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0019 0.0019
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0314 0.0549
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0037 0.0284 0.5249
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0499 1
Schistosoma mansoni biogenic amine receptor 0.0011 0.0019 0.0026
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0357 0.5563
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0019 0.0026
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0037 0.0284 0.5249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0047 0.0394 0.0394
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0037 0.0284 0.5249
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0357 0.2915
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.039 0.7592
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0037 0.0284 0.098
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0314 0.2698
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0592 0.0812
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0019 0.0026
Brugia malayi Dopamine receptor protein 2 0.0011 0.0019 0.0019
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.1038 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0267
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0542 0.863
Echinococcus multilocularis RUN 0.0062 0.0542 0.0542
Echinococcus multilocularis geminin 0.0712 0.7286 0.7286
Schistosoma mansoni ran 0.0044 0.0357 0.049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.1873 0.349
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0334 0.5263
Loa Loa (eye worm) VCP protein 0.0012 0.0024 0.0024
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0037 0.0284 0.5249
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0357 0.3139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0592 0.0592
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.002 0.002
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0019 0.0026
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0046 0.0076
Mycobacterium leprae Probable lipase LipE 0.0042 0.0334 0.8367
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0329 0.5102
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0499 0.0499
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0046 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0274 0.0274
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0608 0.0608
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0404 0.0718
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0357 0.5644
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0334 0.0458
Loa Loa (eye worm) hypothetical protein 0.0068 0.0608 0.0608
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0046 0.0046
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0314 0.4842
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0375 0.0375
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0027 0.0179 0.263
Schistosoma mansoni hypothetical protein 0.0036 0.0274 0.0376
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0334 0.0587
Leishmania major importin beta-1 subunit, putative 0.0048 0.0404 0.377
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0019 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.045 0.0618
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.0334
Leishmania major hypothetical protein, conserved 0.0016 0.0073 0.0522
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2564 0.4759
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0357 0.0357
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0238 0.2376 0.2376
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0037 0.0284 0.5249
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0046 0.0076
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0026
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0046 0.0432
Brugia malayi hypothetical protein 0.0062 0.0542 0.0542
Brugia malayi G-protein coupled receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0059 0.052 0.052
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0019 0.0026
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.2564 0.2564
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0037 0.0284 0.5249
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0334 0.2902
Onchocerca volvulus 0.0062 0.0542 0.101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0229 0.0229
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0046 0.018
Brugia malayi RE15519p 0.0011 0.0019 0.0019
Plasmodium vivax importin-beta 2, putative 0.0059 0.052 0.8281
Mycobacterium tuberculosis Conserved protein 0.0042 0.0334 0.117
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0019 0.0019
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0334 0.3085
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0019 0.0026
Brugia malayi GnHR receptor homolog 0.0011 0.0019 0.0019
Echinococcus multilocularis musashi 0.0028 0.0197 0.0197
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0404 0.0718
Loa Loa (eye worm) hypothetical protein 0.0973 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0019 0.0026
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0375 0.3316
Onchocerca volvulus 0.0011 0.0019 0.0035
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0314 0.043
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0037 0.0284 0.098
Echinococcus granulosus survival motor neuron protein 1 0.0973 1 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0046 0.0046
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0199 0.1963 0.1963
Brugia malayi Pre-SET motif family protein 0.0463 0.4703 0.4703
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0046 0.0076
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0019 0.0026
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0046 0.0046
Echinococcus multilocularis zinc finger protein 0.0025 0.0159 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0627 0.1135
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0037 0.0284 0.098
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0334 0.0587
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0542 0.0542
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0542 0.0542
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0019 0.0019
Trypanosoma brucei cytochrome P450, putative 0.0045 0.0375 0.3488
Onchocerca volvulus 0.0028 0.0197 0.0368
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Entamoeba histolytica Ran family GTPase 0.0044 0.0357 0.5563
Trichomonas vaginalis ran, putative 0.0044 0.0357 0.0631
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0019 0.0019
Trichomonas vaginalis esterase, putative 0.0042 0.0334 0.0587
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0459 0.0459
Schistosoma mansoni transcription factor btf3 0.007 0.0627 0.086
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0627 0.1135
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0109 0.1038 1
Trypanosoma brucei transcription factor BTF3, putative 0.007 0.0627 0.5961
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1649 0.3047
Schistosoma mansoni opsin-like receptor 0.0011 0.0019 0.0026
Schistosoma mansoni opsin-like receptor 0.0011 0.0019 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.1038 0.1424
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.039 0.7592
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0334 0.0587
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1743 0.3223
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0334 0.117
Onchocerca volvulus 0.0042 0.0334 0.0622
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0037 0.0284 0.2594
Brugia malayi Bromodomain containing protein 0.0045 0.0367 0.0367
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0019 0.0019
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0019 0.0019
Echinococcus granulosus importin 5 0.0011 0.002 0.002
Loa Loa (eye worm) oxidoreductase 0.0014 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.1038 0.1904
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0314 0.0549
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0037 0.0284 0.5249
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0046 0.0258
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0031 0.0229 0.0315
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.039 0.7592
Onchocerca volvulus 0.0011 0.0019 0.0035
Schistosoma mansoni amine GPCR 0.0011 0.0019 0.0026
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0046 0.0258
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0605 0.0605
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.004 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0267
Brugia malayi AMP-binding enzyme family protein 0.0047 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0192 0.0192
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0028 0.0194 0.0362
Echinococcus granulosus mitogen activated protein kinase 3 0.0109 0.1038 0.1038
Brugia malayi neuropeptide F receptor 0.0011 0.0019 0.0019
Brugia malayi sulfakinin receptor protein 0.0011 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1649 0.3047
Schistosoma mansoni polycystin 1-related 0.0062 0.0542 0.0744
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0037 0.0284 0.098
Echinococcus multilocularis translational activator gcn1 0.0011 0.002 0.002
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0314 0.043
Loa Loa (eye worm) hypothetical protein 0.0047 0.039 0.039
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.0334
Toxoplasma gondii cytochrome p450 superfamily protein 0.0037 0.0284 0.1109
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Echinococcus granulosus geminin 0.0712 0.7286 0.7286
Echinococcus granulosus sex peptide receptor 0.0011 0.0019 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0037 0.0284 0.098
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0012 0.0024 0.0024
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0031 0.0229 0.0315
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0627 0.5854
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0037 0.0284 0.2398
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.003 0.0101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0334 0.117
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0267 0.4072
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0019 0.0019
Echinococcus multilocularis importin subunit beta 1 0.0059 0.052 0.052
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0267 0.0916
Onchocerca volvulus 0.0011 0.0019 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0085 0.0781 0.1072
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0394 0.0394
Schistosoma mansoni intermediate filament proteins 0.0028 0.0197 0.0271
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.2564 0.2564
Entamoeba histolytica hypothetical protein 0.0036 0.0274 0.4186
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0229 0.0229
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.1511 0.2074
Echinococcus multilocularis serotonin receptor 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0031 0.0229 0.0315
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0314 0.2886
Echinococcus multilocularis GPCR, family 2 0.0031 0.0229 0.0229
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0037 0.0284 0.098
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0027 0.0179 0.0246
Brugia malayi beta-lactamase family protein 0.0042 0.0334 0.0334
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0037 0.0284 0.098
Brugia malayi Importin beta-1 subunit 0.0059 0.052 0.052
Plasmodium vivax transportin, putative 0.0011 0.002 0.0182
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0267
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0019 0.0019
Toxoplasma gondii cell division protein CDC48CY 0.0028 0.0194 0.0759
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Echinococcus granulosus lamin dm0 0.0028 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0404 0.3605
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0037 0.0284 0.5249
Trichomonas vaginalis set domain proteins, putative 0.0527 0.5367 1
Echinococcus granulosus serotonin receptor 0.0011 0.0019 0.0019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0592 0.2311
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0935 0.0935
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0019 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0019 0.0019
Mycobacterium ulcerans lipase LipD 0.0042 0.0334 0.6352
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0019 0.0019
Plasmodium vivax SET domain protein, putative 0.0066 0.0592 0.9434
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0019 0.0019
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0047 0.039 0.039
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0046 0.0076
Schistosoma mansoni histamine h1 receptor 0.0011 0.0019 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0334 0.8367
Echinococcus granulosus allatostatin A receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0085 0.0781 0.0781
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0019 0.0019
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0027 0.0179 0.263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.045 0.0618
Onchocerca volvulus 0.0011 0.0019 0.0035
Trypanosoma cruzi Valosin-containing protein, putative 0.0027 0.0179 0.1345
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0499 1
Echinococcus granulosus hypothetical protein 0.0011 0.0019 0.0019
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0046 0.0432
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0019 0.0019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.019 0.1873 0.1873
Onchocerca volvulus 0.0011 0.0019 0.0035
Leishmania major hypothetical protein, conserved 0.0042 0.0334 0.3085
Mycobacterium ulcerans ATPase 0.0017 0.0077 0.0693
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.1038 0.1904
Loa Loa (eye worm) hypothetical protein 0.0047 0.039 0.039
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0019 0.0019
Brugia malayi Bromodomain containing protein 0.0084 0.0774 0.0774
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0037 0.0284 0.098
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0046 0.0258
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0019 0.0026
Brugia malayi Cytochrome P450 family protein 0.0037 0.0284 0.0284
Onchocerca volvulus 0.0042 0.0334 0.0622
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0542 0.0542
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0197 0.0197
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0712 0.7286 1
Brugia malayi Dopamine receptor protein 1 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus multilocularis 0.0037 0.0284 0.0284
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.039 0.3636
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0592 0.0812
Mycobacterium tuberculosis Conserved protein 0.0042 0.0334 0.117
Brugia malayi neuropeptide F receptor 0.0011 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1743 0.3223
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0092 0.0127
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0037 0.0284 0.2398
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2564 0.4759
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0463 0.4703 0.4703
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0019 0.0019
Schistosoma mansoni rab6-interacting 0.0062 0.0542 0.0744
Brugia malayi Cytochrome P450 family protein 0.0045 0.0375 0.0375
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0153 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.039 1
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2564 0.4759
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0028 0.0194 0.0327
Schistosoma mansoni bromodomain containing protein 0.0071 0.0644 0.0884
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Trypanosoma brucei protein kinase, putative 0.0109 0.1038 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0199 0.1963 0.2694
Brugia malayi AKH receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis mitogen activated protein kinase 3 0.0109 0.1038 0.1038
Echinococcus granulosus somatostatin receptor 0.0011 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0314 0.0549
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0229 0.0229
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0019 0.0019
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0092 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0019 0.0026
Brugia malayi Melatonin receptor type 1A 0.0011 0.0019 0.0019
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.1511 0.1511
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.039 0.1384
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0019 0.0019
Leishmania major cytochrome p450-like protein 0.0045 0.0375 0.3488
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0566 0.0566
Onchocerca volvulus 0.0014 0.0046 0.0086
Brugia malayi hypothetical protein 0.0036 0.0274 0.0274
Leishmania major cytochrome p450-like protein 0.0037 0.0284 0.2594
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.0334
Trypanosoma cruzi ISWI complex protein 0.0016 0.0073 0.0271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0045 0.0045
Mycobacterium leprae putative cytochrome p450 0.0037 0.0284 0.6914
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0062 0.0542 0.0744
Onchocerca volvulus 0.0047 0.039 0.0727
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0499 0.1799
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.0229
Brugia malayi AMP-binding enzyme family protein 0.0047 0.039 0.039
Schistosoma mansoni zinc finger protein 0.0016 0.0073 0.01
Schistosoma mansoni rab6-interacting 0.0062 0.0542 0.0744
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0256 0.256 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0267 0.418
Schistosoma mansoni survival motor neuron protein 0.0199 0.1963 0.2694
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0334 0.0334
Schistosoma mansoni hypothetical protein 0.0031 0.0229 0.0315
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0037 0.0284 0.098
Brugia malayi beta-NAC-like protein 0.007 0.0627 0.0627
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0375 0.0375
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0019 0.0035
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0019 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0136 0.1312 0.1312
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0037 0.0284 0.098
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0019 0.0019
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0022 0.0132 0.0181
Toxoplasma gondii NAC domain-containing protein 0.007 0.0627 0.2447
Brugia malayi vesicle-fusing ATPase 0.0016 0.0074 0.0074
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0314 0.0314
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0019 0.0019
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0542 0.8605
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus granulosus fmrfamide receptor 0.0011 0.0019 0.0019
Schistosoma mansoni lamin 0.0028 0.0197 0.0271
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0394 0.6243
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0357 0.0357
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0394 0.1541
Brugia malayi follicle stimulating hormone receptor 0.0276 0.2771 0.2771
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0109 0.1038 0.1038
Loa Loa (eye worm) hypothetical protein 0.0099 0.0935 0.0935
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Onchocerca volvulus 0.0011 0.0019 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.045 0.045
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0019 0.0019
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0627 0.5854
Brugia malayi Doublecortin family protein 0.0062 0.0542 0.0542
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0314 0.0314
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0334 0.6352
Giardia lamblia Kinase, CMGC MAPK 0.0109 0.1038 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Conserved protein 0.0042 0.0334 0.117
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0274 0.0274
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0635 0.6493 0.8911
Echinococcus multilocularis importin 5 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0357 0.3139
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0012 0.0024 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2564 0.4759
Schistosoma mansoni biogenic amine receptor 0.0011 0.0019 0.0026
Mycobacterium ulcerans beta-lactamase 0.0042 0.0334 0.6352
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.052 0.2032
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0109 0.1038 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0011 0.0019 0.0026
Entamoeba histolytica hypothetical protein 0.0048 0.0404 0.6325
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0019 0.0026
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0329 0.2624
Brugia malayi N-terminal motif family protein 0.019 0.1873 0.1873
Schistosoma mansoni lamin 0.0028 0.0197 0.0271
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0635 0.6493 0.6493
Trypanosoma brucei Valosin-containing protein 0.0027 0.0179 0.1568
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0027 0.0179 0.1568
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1649 0.3047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.045 0.045
Plasmodium falciparum basic transcription factor 3b, putative 0.007 0.0627 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0334 0.0587
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.1038 0.1904
Echinococcus granulosus histone lysine methyltransferase setb 0.0085 0.0781 0.0781
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0627 0.1135
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0394 0.0701
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0046 0.0258
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0499 0.0685
Onchocerca volvulus 0.0014 0.0046 0.0086
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.002 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.1038 0.1904
Loa Loa (eye worm) hypothetical protein 0.0062 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0267
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0276 0.2771 0.2771
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0019 0.0019
Onchocerca volvulus 0.0014 0.0046 0.0086
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0045 0.0375 0.7259
Schistosoma mansoni amine GPCR 0.0011 0.0019 0.0026
Brugia malayi cytochrome P450 0.0037 0.0284 0.0284
Schistosoma mansoni ran 0.0044 0.0357 0.049
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0109 0.1038 1
Mycobacterium ulcerans hypothetical protein 0.0042 0.0334 0.6352
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.002 0.0077
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0314 0.2459
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0019 0.0019
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0046 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Schistosoma mansoni loxhd1 0.0062 0.0542 0.0744
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0247 0.084
Brugia malayi Serotonin receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Onchocerca volvulus 0.0018 0.0086 0.0161
Brugia malayi MAP kinase sur-1 0.0109 0.1038 0.1038
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0019 0.0026
Echinococcus granulosus transportin 1 0.0011 0.002 0.002
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.1511 0.1511
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0012 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.007 0.0627 1
Onchocerca volvulus 0.0527 0.5367 1
Schistosoma mansoni amine GPCR 0.0011 0.0019 0.0026
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0085 0.0781 0.0781
Brugia malayi Cytochrome P450 family protein 0.0045 0.0375 0.0375
Echinococcus multilocularis serotonin receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0019 0.0019
Schistosoma mansoni lipoxygenase 0.0128 0.1226 0.1683
Echinococcus multilocularis lamin 0.0028 0.0197 0.0197
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0935 0.0935
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0267
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0037 0.0284 0.5249
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.039 1
Loa Loa (eye worm) vesicle-fusing ATPase 0.0016 0.0074 0.0074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0197 0.0197
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.039 0.7592
Plasmodium falciparum importin beta, putative 0.0059 0.052 0.8249
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0019 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0046 0.0046
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0092 0.0092
Onchocerca volvulus 0.0011 0.0019 0.0035
Brugia malayi intermediate filament protein 0.0028 0.0197 0.0197
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0334 0.117
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.052 0.4917
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0062 0.0542 0.0542
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.045 0.045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0046 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0267 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0334 0.0334
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0394 0.0701
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0061 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Echinococcus multilocularis mitogen activated protein kinase 0.0109 0.1038 0.1038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0085 0.0781 0.1072
Onchocerca volvulus 0.0011 0.0019 0.0035
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0247 0.084
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0026
Brugia malayi Cytochrome P450 family protein 0.0136 0.1312 0.1312
Onchocerca volvulus 0.0011 0.0019 0.0035
Brugia malayi Dopamine receptor 0.0011 0.0019 0.0019
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0046 0.0049
Trypanosoma brucei ISWI complex protein 0.0016 0.0073 0.0522
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0109 0.1038 0.4053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1649 0.3047
Brugia malayi Pre-SET motif family protein 0.0066 0.0592 0.0592
Echinococcus granulosus GPCR family 2 0.0031 0.0229 0.0229
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.039 0.61
Loa Loa (eye worm) hypothetical protein 0.0041 0.0329 0.0329
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0019 0.0019
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0046 0.0046
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0394 0.1541
Onchocerca volvulus 0.0011 0.0019 0.0035
Brugia malayi valosin containing protein 0.0016 0.0074 0.0074
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0037 0.0284 0.5249
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.045 0.045
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0046 0.0076
Loa Loa (eye worm) cytochrome P450 0.0037 0.0284 0.0284
Brugia malayi kap beta 3 protein 0.0011 0.002 0.002
Echinococcus granulosus mitogen activated protein kinase 0.0109 0.1038 0.1038
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0334 0.117
Brugia malayi AMP-binding enzyme family protein 0.0047 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.144 0.144
Schistosoma mansoni biogenic amine receptor 0.0011 0.0019 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0019 0.0019
Brugia malayi RNA, U transporter 1 0.0169 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) ICD-1 protein 0.007 0.0627 0.0627
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.039 0.61
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0314 0.0314
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.039 0.3636
Schistosoma mansoni lipoxygenase 0.0238 0.2376 0.3262
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.01
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0334 0.6352
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0019 0.0019
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0357 0.3316
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0935 0.0935
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0037 0.0284 0.5249
Leishmania major basic transcription factor 3a, putative 0.007 0.0627 0.5961
Loa Loa (eye worm) beta-lactamase 0.0042 0.0334 0.0334
Echinococcus granulosus neuropeptide receptor 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0037 0.0284 0.039
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0375 0.3316
Onchocerca volvulus 0.0011 0.0019 0.0035
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0314 0.0314
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0542 0.0542
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0028 0.0194 0.0194

Activities

Activity type Activity value Assay description Source Reference
ED99.9 (functional) > 1.5 mg kg-1 In vivo anti-Candida activity was determined in a mouse model of disseminated candidiasis (TOKA). ChEMBL. No reference
IC50 (binding) > 0.2 uM Tested for inhibition of Beta-1,3-glucan synthase using a crude membrane of Candida albicans (MY 1208). ChEMBL. No reference
IC50 (binding) > 0.2 uM Tested for inhibition of Beta-1,3-glucan synthase using a crude membrane of Candida albicans (MY 1208). ChEMBL. No reference
MFC (functional) = 4 ug ml-1 In vitro Fungicidal activity (MFC) of the compound was tested against Candida albicans (MY 1055). ChEMBL. No reference
MFC (functional) = 4 ug ml-1 In vitro Fungicidal activity (MFC) of the compound was tested against Candida albicans (MY 1055). ChEMBL. No reference
MFC (functional) = 8 ug ml-1 In vitro Fungicidal activity (MFC) of the compound was tested against C. parapsilosis (MY 1010). ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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