Detailed information for compound 403574

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2479.65 | Formula: C114H147N23O36S2
  • H donors: 28 H acceptors: 36 LogP: -2.69 Rotable bonds: 90
    Rule of 5 violations (Lipinski): 4
  • SMILES: CSCC[C@@H](C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N1CCC[C@@H]1C(=O)N)CO)Cc1ccc(cc1)O)CC(=O)O)CCC(=O)O)CC(=O)O)C)NC(=O)c1ccc(cc1)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)C)CCSC)CC(=O)O)Cc1ccccc1)CC(=O)O)CC(=O)O)CC(C)C)CC(=O)N)Cc1ccccc1
  • InChi: 1S/C114H147N23O36S2/c1-58(2)44-73(124-107(166)81(52-92(148)149)133-110(169)83(54-94(152)153)131-102(161)75(46-62-20-11-8-12-21-62)126-109(168)82(53-93(150)151)132-104(163)77(48-66-56-117-69-23-14-13-22-68(66)69)128-100(159)71(37-42-174-5)120-60(4)139)101(160)129-78(49-88(115)141)105(164)125-74(45-61-18-9-7-10-19-61)98(157)118-55-64-27-31-65(32-28-64)97(156)122-72(38-43-175-6)112(171)137-41-17-26-87(137)114(173)136-40-16-25-86(136)111(170)119-59(3)96(155)123-79(50-90(144)145)106(165)121-70(35-36-89(142)143)99(158)130-80(51-91(146)147)108(167)127-76(47-63-29-33-67(140)34-30-63)103(162)134-84(57-138)113(172)135-39-15-24-85(135)95(116)154/h7-14,18-23,27-34,56,58-59,70-87,117,138,140H,15-17,24-26,35-55,57H2,1-6H3,(H2,115,141)(H2,116,154)(H,118,157)(H,119,170)(H,120,139)(H,121,165)(H,122,156)(H,123,155)(H,124,166)(H,125,164)(H,126,168)(H,127,167)(H,128,159)(H,129,160)(H,130,158)(H,131,161)(H,132,163)(H,133,169)(H,134,162)(H,142,143)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)/t59-,70+,71-,72-,73-,74-,75-,76+,77-,78-,79+,80+,81-,82-,83-,84+,85+,86+,87+/m0/s1
  • InChiKey: FDCJZUCBUREVKU-AVTWMHHVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-X-C motif) ligand 8 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum LCCL domain-containing protein chemokine (C-X-C motif) ligand 8 99 aa 80 aa 25.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0114 0.0302 0.0302
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Brugia malayi Patched related family protein 4 0.0018 0.0034 0.0099
Onchocerca volvulus Pyruvate kinase homolog 0.0101 0.0266 0.2761
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0022 0.0062
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0312 0.0859 0.2486
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0019 0.0019
Brugia malayi RNA binding protein 0.0071 0.0183 0.053
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.1017 0.2943
Brugia malayi Patched related family protein 10 0.0018 0.0034 0.0099
Brugia malayi Polyprenyl synthetase family protein 0.0312 0.0859 0.2486
Brugia malayi Polyprenyl synthetase family protein 0.1235 0.3454 1
Echinococcus multilocularis neuropeptide receptor A26 0.0486 0.1349 0.1349
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0271 0.0749
Trypanosoma cruzi ISWI complex protein 0.0016 0.0028 0.008
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0312 0.0859 0.0859
Echinococcus granulosus pyruvate kinase 0.0101 0.0266 0.0266
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0103 0.0297
Onchocerca volvulus Pyruvate kinase homolog 0.0101 0.0266 0.2761
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0068 0.0197
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0312 0.0859 0.2486
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0068 0.0197
Mycobacterium leprae Probable pyruvate kinase PykA 0.0101 0.0266 0.2986
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0014 0.004
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.006 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0084 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0349 0.1009
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0014 0.004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3353 0.941 0.941
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0005
Onchocerca volvulus 0.0014 0.0022 0.0224
Loa Loa (eye worm) hypothetical protein 0.0109 0.0288 0.0834
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0076
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0029 0.0083
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0034 0.0098
Plasmodium falciparum flap endonuclease 1 0.0027 0.006 0.0173
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.006 0.0173
Leishmania major cytochrome p450-like protein 0.0011 0.0014 0.004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0145 0.0391 0.4558
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0032
Schistosoma mansoni DNA ligase IV 0.003 0.0068 0.0068
Brugia malayi hypothetical protein 0.003 0.0068 0.0197
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0183 0.053
Brugia malayi TAR-binding protein 0.0071 0.0183 0.053
Trypanosoma cruzi ISWI complex protein 0.0016 0.0028 0.008
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0043 0.0103 0.0258
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0312 0.0859 0.2456
Leishmania major cytochrome p450-like protein 0.0011 0.0014 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0006 0.0000000035496 0.000000010276
Toxoplasma gondii bromodomain-containing protein 0.0006 0.0000000035496 0.000000010276
Echinococcus multilocularis 0.0011 0.0014 0.0014
Brugia malayi jmjC domain containing protein 0.0016 0.0029 0.0083
Schistosoma mansoni hypothetical protein 0.0125 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Toxoplasma gondii patched family protein 0.0018 0.0034 0.0099
Echinococcus multilocularis flap endonuclease 1 0.0027 0.006 0.006
Onchocerca volvulus 0.0145 0.0391 0.4061
Trichomonas vaginalis glucosylceramidase, putative 0.0532 0.1478 0.4279
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0205 0.0558 0.6409
Giardia lamblia Pyruvate kinase 0.0101 0.0266 0.077
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0197
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0103 0.0258
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.003 0.0068 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0068 0.0197
Loa Loa (eye worm) hypothetical protein 0.0109 0.0288 0.0834
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Brugia malayi hypothetical protein 0.0041 0.0098 0.0285
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0043 0.0103 0.0297
Echinococcus granulosus pyruvate kinase 0.0052 0.0128 0.0128
Onchocerca volvulus 0.0031 0.0069 0.0718
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0217 0.0628
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0312 0.0859 0.0859
Leishmania major pteridine reductase 1 0.0014 0.0022 0.0062
Brugia malayi hypothetical protein 0.0114 0.0302 0.0875
Echinococcus granulosus nibrin 0.003 0.0068 0.0068
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Echinococcus multilocularis expressed conserved protein 0.0285 0.0784 0.0784
Mycobacterium tuberculosis Probable oxidoreductase 0.0014 0.0022 0.0023
Schistosoma mansoni zinc finger protein 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0029 0.0029
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0049 0.0101
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0203 0.2169
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0033 0.0033
Echinococcus multilocularis zinc finger protein 0.0026 0.0055 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0029 0.0083
Leishmania major oxidoreductase-like protein 0.0014 0.0022 0.0062
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0116 0.0336
Echinococcus granulosus dnaJ subfamily C 6 0.0065 0.0164 0.0164
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0203 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0068 0.0197
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0097 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0249 0.0249
Entamoeba histolytica hypothetical protein 0.0114 0.0302 0.3522
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.0022 0.0023
Echinococcus granulosus bloom syndrome protein 0.0027 0.0059 0.0059
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0312 0.0859 0.2486
Plasmodium falciparum pyruvate kinase 0.0101 0.0266 0.077
Echinococcus granulosus dnaJ subfamily B 0.0428 0.1185 0.1185
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0006 0.000000000012938 0.000000000037457
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0005
Echinococcus granulosus raf serine:threonine protein kinase 0.0044 0.0105 0.0105
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0637 0.0637
Echinococcus multilocularis dnaJ subfamily C 6 0.0065 0.0164 0.0164
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0312 0.0859 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0029 0.0083
Schistosoma mansoni hypothetical protein 0.0125 0.0335 0.0335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0271 0.0749
Leishmania major pyruvate kinase 0.0101 0.0266 0.077
Toxoplasma gondii hypothetical protein 0.0018 0.0034 0.0099
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0183 0.0183
Echinococcus granulosus neuropeptide s receptor 0.0486 0.1349 0.1349
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0014 0.0014
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1235 0.3454 1
Plasmodium vivax pyruvate kinase 2, putative 0.0052 0.0128 0.0371
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0068 0.0197
Onchocerca volvulus 0.0043 0.0103 0.1065
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0014 0.004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0032
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0014 0.0022 0.0023
Echinococcus multilocularis musashi 0.0027 0.0059 0.0059
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0032
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0043 0.0103 0.0258
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0197
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0217 0.0217
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Echinococcus multilocularis sterol regulatory element binding protein 0.013 0.0349 0.0349
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0005
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1235 0.3454 0.3454
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0011
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0416 0.0416
Leishmania major pyruvate kinase 0.0101 0.0266 0.077
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0203 0.0588
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0127 0.0127
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0011 0.0115
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0043 0.0103 0.0258
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0014 0.0022 0.0062
Plasmodium falciparum bromodomain protein 1 0.0006 0.0000000035496 0.000000010276
Onchocerca volvulus Huntingtin homolog 0.0128 0.0343 0.3557
Loa Loa (eye worm) hypothetical protein 0.0101 0.0266 0.077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0166 0.0166
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0032
Brugia malayi ecdysteroid receptor 0.001 0.0011 0.0032
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0059 0.017
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0183 0.053
Brugia malayi Pre-SET motif family protein 0.0211 0.0575 0.1665
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Mycobacterium ulcerans hypothetical protein 0.0145 0.0391 0.1097
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0043 0.0103 0.0297
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0109 0.0288 0.3184
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0203 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0032
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0014 0.0022 0.0022
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0103 0.0297
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0043 0.0103 0.0297
Brugia malayi pyruvate kinase 0.0021 0.0042 0.0123
Loa Loa (eye worm) polyprenyl synthetase 0.1235 0.3454 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0014 0.0022 0.0023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0011 0.0032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0064 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0145 0.0391 0.1133
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0069 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0103 0.0258
Loa Loa (eye worm) pyruvate kinase 0.0021 0.0042 0.0123
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0312 0.0859 1
Echinococcus granulosus tar DNA binding protein 0.0071 0.0183 0.0183
Trypanosoma brucei pyruvate kinase 1 0.0101 0.0266 0.077
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0014 0.0022 0.0062
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0145 0.0391 0.4469
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.0391 0.1133
Toxoplasma gondii patched family protein 0.0018 0.0034 0.0099
Treponema pallidum DNA ligase (lig) 0.003 0.0068 0.0239
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0321
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0271 0.0749
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0166 0.0166
Loa Loa (eye worm) patched family protein 0.0018 0.0034 0.0099
Leishmania major solanesyl-diphosphate synthase, putative 0.0312 0.0859 0.2486
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.003 0.0068 0.064
Trypanosoma cruzi pyruvate kinase 2, putative 0.0101 0.0266 0.077
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0043 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Plasmodium falciparum pyruvate kinase 2 0.0052 0.0128 0.0371
Entamoeba histolytica hypothetical protein 0.0114 0.0302 0.3522
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0033 0.0033
Loa Loa (eye worm) DnaJ domain-containing protein 0.0065 0.0164 0.0475
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0049 0.0119 0.0345
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0103 0.0297
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0049 0.014
Toxoplasma gondii ATPase, AAA family protein 0.003 0.0068 0.0197
Schistosoma mansoni hypothetical protein 0.0047 0.0116 0.0116
Entamoeba histolytica ankyrin repeat protein, putative 0.0006 0.0000000035496 0.000000041342
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0049 0.0322
Echinococcus multilocularis pyruvate kinase 0.0052 0.0128 0.0128
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1235 0.3454 1
Brugia malayi ATPase, AAA family protein 0.0006 0.00000032318 0.00000093563
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0111 0.0321
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0043 0.0103 0.0258
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0173 0.0173
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0011 0.0011
Onchocerca volvulus 0.0014 0.0022 0.0224
Brugia malayi hypothetical protein 0.0018 0.0034 0.0099
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0127 0.0127
Brugia malayi CXXC zinc finger family protein 0.003 0.0067 0.0194
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0059 0.017
Echinococcus multilocularis geminin 0.0535 0.1485 0.1485
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0249 0.0249
Brugia malayi Cytochrome P450 family protein 0.0011 0.0014 0.004
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0014 0.0022 0.0251
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0119 0.0119
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0312 0.0859 0.2486
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0145 0.0391 0.1097
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0103 0.0258
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0032
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0043 0.0103 0.0258
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0043 0.0103 0.0297
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0127 0.0329
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0532 0.1478 0.4279
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0183 0.053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0103 0.0258
Onchocerca volvulus 0.0027 0.0059 0.0608
Trypanosoma brucei oxidoreductase-like protein 0.0014 0.0022 0.0062
Trichomonas vaginalis helicase, putative 0.0007 0.0002 0.0005
Brugia malayi Pyruvate kinase, M2 isozyme 0.0101 0.0266 0.077
Toxoplasma gondii pyruvate kinase PyKII 0.0052 0.0128 0.0371
Trichomonas vaginalis glucosylceramidase, putative 0.0532 0.1478 0.4279
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0014 0.004
Echinococcus granulosus global transcription activator snf2l2 0.0006 0.000000000012938 0.000000000012938
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0197
Echinococcus granulosus Niemann Pick C1 protein 0.0303 0.0835 0.0835
Schistosoma mansoni bromodomain containing protein 0.0072 0.0184 0.0184
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0103 0.0297
Loa Loa (eye worm) hypothetical protein 0.0303 0.0835 0.2419
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0312 0.0859 0.2486
Schistosoma mansoni hypothetical protein 0.0428 0.1185 0.1185
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0017 0.005
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.0397 0.0397
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0023 0.027
Schistosoma mansoni cpg binding protein 0.0034 0.0077 0.0077
Brugia malayi jmjC domain containing protein 0.0062 0.0156 0.045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0069 0.02
Brugia malayi BRM protein 0.0006 0.000000000012938 0.000000000037457
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0203 0.1908
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0312 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0006 0.00000032318 0.00000093563
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0023 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.0964 0.279
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0032
Loa Loa (eye worm) histone methyltransferase 0.001 0.0012 0.0034
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0049 0.0143
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0014 0.004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0011 0.0011
Schistosoma mansoni survival motor neuron protein 0.0047 0.0116 0.0116
Echinococcus granulosus sterol regulatory element binding protein 0.013 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0119 0.0119
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0032
Schistosoma mansoni dihydropteridine reductase 0.0014 0.0022 0.0022
Brugia malayi Pax transcription activation domain interacting protein 0.003 0.0068 0.0197
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0103 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0103 0.0258
Brugia malayi hypothetical protein 0.0233 0.0637 0.1844
Brugia malayi protein C24B5.3 0.0018 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.0145 0.0391 0.1133
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0054 0.0054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0145 0.0391 0.4558
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0011 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0069 0.0069
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0097 0.1135
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0183 0.0183
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0026 0.0076
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0059 0.017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0145 0.0391 0.1097
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Echinococcus granulosus flap endonuclease 1 0.0027 0.006 0.006
Chlamydia trachomatis DNA ligase 0.003 0.0068 0.0553
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0002 0.0004
Chlamydia trachomatis pyruvate kinase 0.0101 0.0266 0.2921
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0084 0.0244
Loa Loa (eye worm) patched family protein 0.0018 0.0034 0.0099
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0033 0.0097
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0026 0.0076
Echinococcus multilocularis microtubule associated protein 2 0.3563 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0103 0.0258
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.0022 0.0023
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1235 0.3454 1
Loa Loa (eye worm) oxidoreductase 0.0014 0.0022 0.0062
Mycobacterium ulcerans oxidoreductase 0.0014 0.0022 0.0023
Onchocerca volvulus 0.001 0.0011 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0183 0.0183
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0109 0.0288 0.0834
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.006 0.0173
Trypanosoma cruzi pyruvate kinase 2, putative 0.0101 0.0266 0.077
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0203 0.0203
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0026 0.0076
Brugia malayi Bromodomain containing protein 0.0044 0.0106 0.0306
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0637 0.0637
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0205 0.0558 0.1615
Brugia malayi hypothetical protein 0.0041 0.0098 0.0285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0043 0.0103 0.0258
Echinococcus multilocularis pyruvate kinase 0.0101 0.0266 0.0266
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0029 0.0083
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1235 0.3454 1
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0312 0.0859 0.2456
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0312 0.0859 0.2486
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0005
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0205 0.0558 0.6409
Toxoplasma gondii patched family protein 0.0018 0.0034 0.0099
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0126 0.0365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0249 0.0249
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0103 0.0297
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0069 0.0069
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0217 0.0217
Brugia malayi DKFZp564C0469 protein 0.003 0.0068 0.0197
Schistosoma mansoni hypothetical protein 0.0535 0.1485 0.1485
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0043 0.0125
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0043 0.0043
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0103 0.0297
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Onchocerca volvulus 0.024 0.0657 0.6816
Brugia malayi protein C24B5.3 0.0018 0.0034 0.0099
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Echinococcus multilocularis protein patched 0.013 0.0349 0.0349
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0203 0.0588
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0029 0.0083
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0115 0.0333
Brugia malayi Patched related family protein 12 0.0018 0.0034 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0043 0.0103 0.0103
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0068 0.0197
Loa Loa (eye worm) hypothetical protein 0.0128 0.0343 0.0992
Onchocerca volvulus 0.0018 0.0034 0.0356
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.006 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0103 0.0258
Schistosoma mansoni hypothetical protein 0.0065 0.0164 0.0164
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0026 0.0026
Onchocerca volvulus 0.0018 0.0034 0.0356
Loa Loa (eye worm) hypothetical protein 0.0145 0.0391 0.1133
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0076
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1235 0.3454 0.3454
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0026
Schistosoma mansoni cpg binding protein 0.003 0.0067 0.0067
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0312 0.0859 0.0859
Brugia malayi hypothetical protein 0.003 0.0068 0.0197
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0127 0.1341
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0145 0.0391 0.1097
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0033 0.0033
Mycobacterium tuberculosis Possible oxidoreductase 0.0014 0.0022 0.0023
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0014 0.004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0026
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0532 0.1478 0.4279
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0043 0.0103 0.0258
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.006 0.0173
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.0391 0.1133
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0011
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0029 0.0083
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0127 0.0329
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0312 0.0859 0.2486
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.0964 0.279
Brugia malayi topoisomerase 0.003 0.0068 0.0197
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0039 0.0039
Plasmodium vivax replication factor C subunit 1, putative 0.003 0.0068 0.0197
Echinococcus granulosus geminin 0.0535 0.1485 0.1485
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Schistosoma mansoni hypothetical protein 0.0125 0.0335 0.0335
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0145 0.0391 0.1097
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0006 0.00000032318 0.00000032318
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0203 0.2169
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0043 0.0103 0.0258
Brugia malayi hypothetical protein 0.0018 0.0034 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0007 0.0007
Giardia lamblia Pyruvate kinase 0.0052 0.0128 0.0371
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.0964 0.279
Echinococcus multilocularis nibrin 0.003 0.0068 0.0068
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0203 0.055
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0203 0.2241
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.0391 0.1133
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0014
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0049 0.014
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0014 0.0022 0.0022
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0014 0.004
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0029 0.0029
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0111 0.0321
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Schistosoma mansoni cytochrome P450 0.0011 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0014 0.0022 0.0092
Loa Loa (eye worm) RecQ helicase 0.0027 0.0059 0.017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0119 0.0119
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0166 0.0166
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0163 0.0472
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0045 0.013
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0014 0.0022 0.0022
Brugia malayi steroid hormone receptor 0.001 0.0011 0.0032
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0014 0.0022 0.0062
Entamoeba histolytica Flap nuclease, putative 0.0027 0.006 0.0696
Loa Loa (eye worm) cytochrome P450 0.0011 0.0014 0.004
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0084 0.0244
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0014 0.004
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0014 0.004
Echinococcus granulosus G protein signaling modulator 2 0.0012 0.0017 0.0017
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0014 0.0014
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Echinococcus multilocularis Niemann Pick C1 protein 0.0303 0.0835 0.0835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Schistosoma mansoni glutathione synthetase 0.0312 0.0859 0.0859
Onchocerca volvulus 0.0018 0.0034 0.0356
Brugia malayi jmjC domain containing protein 0.0016 0.0029 0.0083
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0011
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0049 0.014
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0203 0.2169
Loa Loa (eye worm) patched family protein 0.0018 0.0034 0.0099
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0014 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0005
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0006 0.00000032318 0.00000032318
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0039 0.0039
Echinococcus granulosus phd:f box containing protein 0.0016 0.0029 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0032
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0023 0.0067
Onchocerca volvulus 0.0018 0.0034 0.0356
Trichomonas vaginalis glucosylceramidase, putative 0.0532 0.1478 0.4279
Schistosoma mansoni hypothetical protein 0.0022 0.0043 0.0043
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1235 0.3454 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0023 0.0067
Mycobacterium ulcerans pyruvate kinase 0.0101 0.0266 0.0733
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0049 0.0101
Loa Loa (eye worm) hypothetical protein 0.0136 0.0365 0.1057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0011
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0115 0.0333
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0026 0.0076
Onchocerca volvulus 0.0083 0.0217 0.2252
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0029 0.0029
Echinococcus granulosus FTZ F1 alpha 0.001 0.0011 0.0011
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0068 0.0197
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0067 0.0194
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0026 0.0026
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0312 0.0859 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0156 0.0156
Brugia malayi Augmenter of liver regeneration 0.0036 0.0084 0.0244
Toxoplasma gondii propionate-CoA ligase 0.0043 0.0103 0.0297
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0029 0.0029
Schistosoma mansoni DNA helicase recq1 0.0011 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0032
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0014 0.0022 0.0062
Schistosoma mansoni pyruvate kinase 0.0101 0.0266 0.0266
Echinococcus granulosus pyruvate kinase 0.0052 0.0128 0.0128
Schistosoma mansoni zinc finger protein 0.0026 0.0055 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.0964 0.279
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.004
Plasmodium vivax patched family protein, putative 0.0018 0.0034 0.0099
Leishmania major cytochrome p450-like protein 0.0011 0.0014 0.004
Echinococcus granulosus lamin 0.0027 0.0059 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0103 0.0258
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0302 0.0302
Brugia malayi PHD-finger family protein 0.0031 0.0071 0.0206
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0165 0.0165
Echinococcus granulosus cpg binding protein 0.0034 0.0077 0.0077
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.006 0.0173
Onchocerca volvulus Protein patched homolog 0.0018 0.0034 0.0356
Echinococcus multilocularis pyruvate kinase 0.008 0.0206 0.0206
Schistosoma mansoni lamin 0.0027 0.0059 0.0059
Giardia lamblia Replication factor C, subunit 1 0.003 0.0068 0.0197
Echinococcus multilocularis lamin 0.0027 0.0059 0.0059
Trypanosoma brucei pyruvate kinase 1, putative 0.0101 0.0266 0.077
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0031 0.0068 0.0198
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0002 0.0004
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0217 0.0217
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.003 0.0068 0.0791
Loa Loa (eye worm) RNA binding protein 0.0071 0.0183 0.053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0014 0.0014
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.003 0.0068 0.0197
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0014 0.0022 0.0062
Trichomonas vaginalis protein kinase inhibitor, putative 0.0065 0.0164 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0032
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0014 0.004
Loa Loa (eye worm) BRM protein 0.0006 0.000000000012938 0.000000000037457
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0023 0.0068
Echinococcus granulosus Niemann Pick C1 protein 0.0434 0.1201 0.1201
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0103 0.0258
Brugia malayi jmjC domain containing protein 0.0016 0.0029 0.0083
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0011 0.0011
Brugia malayi Cytochrome P450 family protein 0.0011 0.0014 0.004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0019 0.0019
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0312 0.0859 0.2456
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0197
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0023 0.0067
Echinococcus multilocularis cpg binding protein 0.0034 0.0077 0.0077
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0203 0.0588
Schistosoma mansoni flap endonuclease-1 0.0025 0.0052 0.0052
Brugia malayi pyruvate kinase, muscle isozyme 0.0021 0.0042 0.0123
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0068 0.0197
Brugia malayi intermediate filament protein 0.0027 0.0059 0.017
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0014 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0302 0.0302
Schistosoma mansoni bromodomain containing protein 0.001 0.001 0.001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0103 0.0297
Brugia malayi GoLoco motif family protein 0.0012 0.0017 0.0049
Leishmania major polyprenyl synthase, putative 0.0312 0.0859 0.2486
Plasmodium falciparum replication factor C subunit 1, putative 0.003 0.0068 0.0197
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0312 0.0859 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0052
Onchocerca volvulus 0.003 0.0067 0.0696
Brugia malayi Probable ClpP-like protease 0.0078 0.0203 0.0588
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0084 0.0084
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0049 0.0322
Schistosoma mansoni cpg binding protein 0.0034 0.0077 0.0077
Loa Loa (eye worm) oxidoreductase 0.0043 0.0103 0.0297
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1235 0.3454 1
Echinococcus granulosus zinc finger protein 0.0026 0.0055 0.0055
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0205 0.0558 0.6442
Echinococcus granulosus Protein patched homolog 1 0.013 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0049 0.0411
Schistosoma mansoni helicase 0.0006 0.000000000012938 0.000000000012938
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0059 0.017
Echinococcus multilocularis protein dispatched 1 0.0149 0.04 0.04
Loa Loa (eye worm) raf kinase 0.0044 0.0105 0.0304
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0166 0.048
Loa Loa (eye worm) hypothetical protein 0.0145 0.0391 0.1133
Loa Loa (eye worm) retinol dehydrogenase 12 0.0014 0.0022 0.0062
Loa Loa (eye worm) pyruvate kinase 0.0101 0.0266 0.077
Trypanosoma brucei ISWI complex protein 0.0016 0.0028 0.008
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0205 0.0558 0.1582
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0249 0.0722
Brugia malayi Cytochrome P450 family protein 0.0051 0.0126 0.0365
Trypanosoma brucei pteridine reductase 1 0.0014 0.0022 0.0062
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0156 0.0156
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0014 0.0022 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0205 0.0558 0.1615
Schistosoma mansoni hypothetical protein 0.0046 0.0111 0.0111
Plasmodium vivax SET domain containing protein 0.0008 0.0005 0.0014
Onchocerca volvulus 0.0027 0.0059 0.0608
Echinococcus multilocularis neuropeptide s receptor 0.0486 0.1349 0.1349
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1235 0.3454 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0088 0.0088
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0022 0.0062
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0043 0.0103 0.1051
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0043 0.0103 0.0258
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0026 0.0026
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0532 0.1478 0.4279
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0088 0.0088
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0205 0.0558 0.1582
Echinococcus granulosus lamin dm0 0.0027 0.0059 0.0059
Brugia malayi hypothetical protein 0.0128 0.0343 0.0992
Leishmania major farnesyl pyrophosphate synthase 0.1235 0.3454 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0203 0.055
Schistosoma mansoni pyruvate kinase 0.0101 0.0266 0.0266
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0059 0.0059
Brugia malayi jmjC domain containing protein 0.0065 0.0166 0.048
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0011
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0043 0.0103 0.0258
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0575 0.1665
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0115 0.0115
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0084 0.0244
Brugia malayi Patched protein homolog 1 0.0018 0.0034 0.0099
Schistosoma mansoni hypothetical protein 0.0016 0.0028 0.0028
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0014 0.0022 0.0023
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0111 0.0111
Schistosoma mansoni topbp1 0.003 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0083
Loa Loa (eye worm) hypothetical protein 0.0109 0.0288 0.0834
Plasmodium vivax acetyl-CoA synthetase, putative 0.0043 0.0103 0.0297
Echinococcus multilocularis raf serine:threonine protein kinase 0.0044 0.0105 0.0105
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Echinococcus multilocularis lamin dm0 0.0027 0.0059 0.0059
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Brugia malayi hypothetical protein 0.0018 0.0034 0.0099
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0023 0.0067
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0011 0.0011
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0054 0.0054
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0103 0.1051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0032
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0059 0.017
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0043 0.0103 0.0258
Brugia malayi Pre-SET motif family protein 0.0031 0.0069 0.02
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0302 0.0302
Schistosoma mansoni microtubule-associated protein tau 0.3563 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0062
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0312 0.0859 0.0859
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0145 0.0391 0.4469
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0014 0.0022 0.0062
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0308 0.0849 0.0849
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Schistosoma mansoni acetyl-CoA synthetase 0.0043 0.0103 0.0103
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0029 0.0083
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0029 0.0029
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.0964 0.279
Schistosoma mansoni pyruvate kinase 0.0052 0.0128 0.0128
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0086 0.021
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0105 0.0105
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0014 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0068 0.0197
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0109 0.0288 0.0797
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0084 0.0244
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0111 0.0321
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1235 0.3454 1
Echinococcus multilocularis G protein signaling modulator 2 0.0012 0.0017 0.0017
Brugia malayi isocitrate dehydrogenase 0.0016 0.0026 0.0076
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1235 0.3454 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0011 0.0032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0059 0.0124
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.0022 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0011
Echinococcus multilocularis pyruvate kinase 0.0101 0.0266 0.0266
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0043 0.0103 0.0258
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0043 0.0103 0.1195
Brugia malayi CHE-14 protein 0.013 0.0349 0.1009
Onchocerca volvulus 0.0043 0.0103 0.1065
Onchocerca volvulus Huntingtin homolog 0.0128 0.0343 0.3557
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0014 0.0022 0.0062
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0014 0.004
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.1185 0.1185
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0014 0.0022 0.0023
Plasmodium vivax SET domain protein, putative 0.0031 0.0069 0.02
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0416 0.0416
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0103 0.0297
Giardia lamblia Transcription regulatory protein SNF2 0.0006 0.000000000012938 0.000000000037457
Echinococcus multilocularis pyruvate kinase 0.0052 0.0128 0.0128
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.003 0.0068 0.0197
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1235 0.3454 0.3454
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0312 0.0859 1
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0312 0.0859 1
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0145 0.0391 0.1097
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0011 0.0011
Brugia malayi GoLoco motif family protein 0.0012 0.0017 0.0049
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Entamoeba histolytica pyruvate kinase, putative 0.007 0.018 0.21
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0084 0.0084
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0084 0.0244
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1235 0.3454 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0115 0.0333
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0083
Trichomonas vaginalis pyruvate kinase, putative 0.0101 0.0266 0.077
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0068 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0068 0.0197
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0014 0.004
Brugia malayi Pyruvate kinase, muscle isozyme 0.0101 0.0266 0.077
Echinococcus multilocularis replication factor c subunit 1 0.003 0.0068 0.0068
Schistosoma mansoni patched 1 0.013 0.0349 0.0349
Trypanosoma cruzi FHA domain containing protein, putative 0.003 0.0068 0.0197
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0032
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0029 0.0083
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0532 0.1478 0.4279
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0532 0.1478 0.4279
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0312 0.0859 0.2456
Trypanosoma brucei AAA ATPase, putative 0.0006 0.00000032318 0.00000093563
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0103 0.0297
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0312 0.0859 0.2456
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0014 0.0022 0.0062
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0043 0.0103 0.1051
Brugia malayi Raf kinase 0.0044 0.0105 0.0304
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Mycobacterium ulcerans acetyl-CoA synthetase 0.0043 0.0103 0.0258
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0005
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1235 0.3454 1
Echinococcus granulosus pyruvate kinase 0.0101 0.0266 0.0266
Brugia malayi AMP-binding enzyme family protein 0.0145 0.0391 0.1133
Brugia malayi Patched family protein 0.0018 0.0034 0.0099
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.0022 0.0023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0029 0.0029
Toxoplasma gondii pyruvate kinase PyK1 0.0101 0.0266 0.077
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0145 0.0391 0.1097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0032
Echinococcus granulosus expressed conserved protein 0.0285 0.0784 0.0784
Onchocerca volvulus 0.0047 0.0116 0.1204
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0011 0.0011
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0026 0.0076
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0203 0.0203
Onchocerca volvulus Glucosylceramidase homolog 0.0349 0.0964 1
Leishmania major hypothetical protein, conserved 0.0016 0.0028 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0249 0.0249
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0059 0.017
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0014 0.004
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0115 0.0333
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0014 0.0022 0.0062
Echinococcus multilocularis Niemann Pick C1 protein 0.0434 0.1201 0.1201
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0014 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0083 0.0217 0.0628
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0011 0.0032
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0049 0.014
Schistosoma mansoni hypothetical protein 0.0125 0.0335 0.0335
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0026 0.0076
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0056
Schistosoma mansoni lamin 0.0027 0.0059 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.0964 0.279
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0032
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0032
Trypanosoma cruzi polyprenyl synthase, putative 0.0312 0.0859 0.2486
Brugia malayi Flap endonuclease-1 0.0027 0.006 0.0173
Brugia malayi cytochrome P450 0.0011 0.0014 0.004
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0011 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0183 0.0183
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0043 0.0103 0.0258
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0043 0.0103 0.0258
Brugia malayi AMP-binding enzyme family protein 0.0145 0.0391 0.1133
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Onchocerca volvulus Pyruvate kinase homolog 0.0101 0.0266 0.2761
Brugia malayi DnaJ domain containing protein 0.0065 0.0164 0.0475
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0007
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0011 0.0115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Schistosoma mansoni DNA helicase recq5 0.0011 0.0014 0.0014
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0046 0.0111 0.0321
Schistosoma mansoni topbp1 0.003 0.0068 0.0068
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0014 0.0022 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0032
Plasmodium falciparum enoyl-acyl carrier reductase 0.0205 0.0558 0.1615
Onchocerca volvulus 0.003 0.0068 0.0704
Brugia malayi hypothetical protein 0.0018 0.0034 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0249 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.007 0.018 0.0522
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0312 0.0859 0.2486
Brugia malayi Niemann-Pick C1 protein precursor 0.0303 0.0835 0.2419
Trichomonas vaginalis lymphoid specific helicase, putative 0.0006 0.000000000012938 0.000000000037457
Brugia malayi Cytochrome P450 family protein 0.0011 0.0014 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Onchocerca volvulus 0.0018 0.0034 0.0356
Leishmania major hypothetical protein, conserved 0.0036 0.0084 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0032
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0103 0.0297
Schistosoma mansoni intermediate filament proteins 0.0027 0.0059 0.0059
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0011
Giardia lamblia Farnesyl diphosphate synthase 0.1235 0.3454 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0032
Brugia malayi Myosin head containing protein 0.0018 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.005 0.0123 0.0357
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0097 0.0282
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0014 0.0022 0.0023
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0014 0.0022 0.0023
Loa Loa (eye worm) pyruvate kinase 0.0101 0.0266 0.077
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0011 0.0032
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0029 0.0029
Schistosoma mansoni coup transcription factor 0.001 0.0011 0.0011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0014 0.004
Plasmodium vivax pyruvate kinase, putative 0.0101 0.0266 0.077
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0197
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0103 0.0297
Loa Loa (eye worm) GoLoco domain-containing protein family protein 0.0012 0.0017 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0101 0.0266 0.0733
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0011 0.0011
Plasmodium vivax JmjC domain containing protein 0.0016 0.0029 0.0083
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0049 0.014
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0011 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0029 0.0083
Brugia malayi Bromodomain containing protein 0.0084 0.0218 0.0632
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.1017 0.2943
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0156 0.0156
Onchocerca volvulus 0.0018 0.0034 0.0356
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0249 0.0722
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0271 0.0749
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0111 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0005
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0068 0.0197
Plasmodium falciparum acyl-CoA synthetase 0.0109 0.0288 0.0834
Trichomonas vaginalis pyruvate kinase, putative 0.0101 0.0266 0.077
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0203 0.0588
Onchocerca volvulus 0.0043 0.0103 0.1065
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0014 0.004
Schistosoma mansoni hypothetical protein 0.0535 0.1485 0.1485
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0049 0.0101
Entamoeba histolytica hypothetical protein 0.003 0.0068 0.0791
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0029 0.0029
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0103 0.0297
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Entamoeba histolytica hypothetical protein 0.0114 0.0302 0.3522
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0416 0.1204
Echinococcus multilocularis global transcription activator snf2l2 0.0006 0.000000000012938 0.000000000012938
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0014 0.0022 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0103 0.0297
Echinococcus granulosus neuropeptide receptor A26 0.0486 0.1349 0.1349
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0312 0.0859 0.0859
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.0391 0.1097
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0054 0.0054
Schistosoma mansoni chromosome transmission fidelity factor 0.003 0.0068 0.0068
Leishmania major hypothetical protein, conserved 0.0016 0.0029 0.0083
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0312 0.0859 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0084 0.0244
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0303 0.0835 0.973
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0115 0.0333
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0012 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.006 0.0173
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0014 0.0022 0.0092
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0014 0.004
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0026 0.0076
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0014 0.0022 0.0062
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0011 0.0011
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0059 0.017
Plasmodium vivax acyl-CoA synthetase, putative 0.0109 0.0288 0.0834
Treponema pallidum octaprenyl-diphosphate synthase 0.0312 0.0859 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0076
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1235 0.3454 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0233 0.0637 0.1844
Trichomonas vaginalis replication factor C large subunit, putative 0.003 0.0068 0.0197
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0103 0.0297
Brugia malayi jmjC domain containing protein 0.0016 0.0029 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0032
Loa Loa (eye worm) pyruvate kinase 0.0101 0.0266 0.077
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0183 0.0183
Onchocerca volvulus 0.0018 0.0034 0.0356
Loa Loa (eye worm) pyruvate kinase-PB 0.007 0.018 0.0522
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0049 0.014
Schistosoma mansoni hypothetical protein 0.0012 0.0017 0.0017
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0026 0.0076
Loa Loa (eye worm) hypothetical protein 0.013 0.0349 0.1009
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0109 0.0288 0.0797
Loa Loa (eye worm) hypothetical protein 0.0128 0.0343 0.0992
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.0022 0.0023
Trypanosoma cruzi polyprenyl synthase, putative 0.0312 0.0859 0.2486
Echinococcus granulosus intermediate filament protein 0.0027 0.0059 0.0059
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0032
Loa Loa (eye worm) polyprenyl synthetase 0.0312 0.0859 0.2486
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.0391 0.1097
Echinococcus granulosus pyruvate kinase 0.0052 0.0128 0.0128
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0084 0.0244
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.0022 0.0023
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0068 0.0197
Loa Loa (eye worm) hypothetical protein 0.0074 0.0191 0.0552
Schistosoma mansoni trans-prenyltransferase 0.0312 0.0859 0.0859
Toxoplasma gondii hypothetical protein 0.0027 0.0059 0.017
Onchocerca volvulus Protein patched homolog 0.0018 0.0034 0.0356
Trichomonas vaginalis hypothetical protein 0.0205 0.0558 0.1615
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0043 0.0103 0.0258
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0084 0.0244
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0312 0.0859 0.0859
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.013 0.0349 0.1009
Loa Loa (eye worm) hypothetical protein 0.0046 0.0113 0.0327
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0059 0.053
Entamoeba histolytica hypothetical protein 0.0023 0.0049 0.0565
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0011 0.0011
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0103 0.0297
Onchocerca volvulus 0.0043 0.0103 0.1065
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0043 0.0103 0.0297
Loa Loa (eye worm) acetyltransferase 0.0154 0.0416 0.1204
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0103 0.0297
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0033 0.0033
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0011 0.0011
Trichomonas vaginalis set domain proteins, putative 0.024 0.0657 0.1902
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.0964 0.279
Entamoeba histolytica hypothetical protein 0.0114 0.0302 0.3522
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0103 0.0297
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0312 0.0859 0.2486
Echinococcus multilocularis pyruvate kinase 0.0052 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0249 0.0249
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0014 0.0022 0.0062
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0111 0.0321
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.006 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0103 0.0258
Loa Loa (eye worm) hypothetical protein 0.0109 0.0288 0.0834
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0026 0.0036
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0059 0.017
Loa Loa (eye worm) patched family protein 0.0018 0.0034 0.0099
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.0022 0.0023
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0103 0.0297
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0099
Toxoplasma gondii patched family protein 0.0018 0.0034 0.0099
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0103 0.0297
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0011 0.0011
Loa Loa (eye worm) patched family protein 0.0018 0.0034 0.0099
Entamoeba histolytica acyl-coA synthetase, putative 0.0145 0.0391 0.4558
Echinococcus granulosus replication factor c subunit 1 0.003 0.0068 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0119 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.0391 0.1097
Loa Loa (eye worm) hypothetical protein 0.0159 0.0431 0.1248
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0103 0.0258
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.003 0.0068 0.0553
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0005
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0059 0.017

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.3 uM Inhibition of Interleukin-8 (IL-8) ChEMBL. No reference
Ki (binding) = 2.3 uM Inhibition of Interleukin-8 (IL-8) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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