Detailed information for compound 456428

Basic information

Technical information
  • TDR Targets ID: 456428
  • Name: 2-N-[(2-chlorophenyl)methyl]-4-N-[[4-(dimethy laminomethyl)cyclohexyl]methyl]-5-nitropyrimi dine-2,4-diamine
  • MW: 432.947 | Formula: C21H29ClN6O2
  • H donors: 2 H acceptors: 4 LogP: 5.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CC1CCC(CC1)CNc1nc(ncc1[N+](=O)[O-])NCc1ccccc1Cl)C
  • InChi: 1S/C21H29ClN6O2/c1-27(2)14-16-9-7-15(8-10-16)11-23-20-19(28(29)30)13-25-21(26-20)24-12-17-5-3-4-6-18(17)22/h3-6,13,15-16H,7-12,14H2,1-2H3,(H2,23,24,25,26)
  • InChiKey: JIEPFEWJSJUYOR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N2-[(2-chlorophenyl)methyl]-N4-[[4-(dimethylaminomethyl)cyclohexyl]methyl]-5-nitro-pyrimidine-2,4-diamine
  • N2-[(2-chlorophenyl)methyl]-N4-[[4-(dimethylaminomethyl)cyclohexyl]methyl]-5-nitropyrimidine-2,4-diamine
  • [4-[[[2-[(2-chlorobenzyl)amino]-5-nitro-pyrimidin-4-yl]amino]methyl]cyclohexyl]methyl-dimethyl-amine
  • N-[(2-chlorophenyl)methyl]-N'-[[4-(dimethylaminomethyl)cyclohexyl]methyl]-5-nitropyrimidine-2,4-diamine
  • N-[(2-chlorophenyl)methyl]-N'-[[4-(dimethylaminomethyl)cyclohexyl]methyl]-5-nitro-pyrimidine-2,4-diamine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL References
Homo sapiens protein kinase C, theta Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CAMK/PIM protein kinase 0.042 0.3086 0.3358
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0134 0.0617 0.0828
Brugia malayi Variant SH3 domain containing protein 0.0113 0.0434 0.0472
Echinococcus granulosus Mastin 0.0216 0.1324 0.1323
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0665 0.2522
Schistosoma mansoni hypothetical protein 0.0216 0.1324 0.1776
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0484 0.3634 0.3634
Loa Loa (eye worm) hypothetical protein 0.0279 0.1862 0.2026
Brugia malayi serine/threonine protein kinase 6 0.0172 0.0941 0.1024
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0086 0.0199 0.0217
Echinococcus granulosus slit 2 protein 0.0074 0.0094 0.0094
Brugia malayi STE20-like kinase MST 0.0305 0.2094 0.2279
Plasmodium falciparum calcium-dependent protein kinase 5 0.0118 0.0478 0.0397
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Trypanosoma cruzi cdc2-related kinase 3 0.014 0.0665 0.0891
Brugia malayi Variant SH3 domain containing protein 0.0103 0.035 0.0381
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0118 0.0478 0.0478
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.042 0.3086 0.3085
Schistosoma mansoni hypothetical protein 0.0063 0.0001 0.0001
Echinococcus granulosus serine:threonine protein kinase 0.0134 0.0616 0.0615
Echinococcus granulosus tyrosine protein kinase Fyn 0.0264 0.1739 0.1739
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0082 0.0168 0.0203
Loa Loa (eye worm) CDC7 protein kinase 0.0105 0.0364 0.0396
Echinococcus multilocularis slit 2 protein 0.0074 0.0094 0.0114
Brugia malayi Tensin 0.0063 0.0001 0.0001
Brugia malayi protein-tyrosine kinase 0.0224 0.139 0.1513
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0135 0.0626 0.0625
Loa Loa (eye worm) hypothetical protein 0.0554 0.4239 0.4612
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0279 0.1868 0.1868
Trichomonas vaginalis AGC family protein kinase 0.0368 0.2634 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0734 0.579 0.6301
Trichomonas vaginalis AGC family protein kinase 0.0172 0.0941 0.3571
Giardia lamblia Kinase, CMGC CLK 0.0182 0.1025 0.9643
Onchocerca volvulus 0.0134 0.0617 0.0827
Brugia malayi casein kinase I 0.0128 0.0559 0.0609
Loa Loa (eye worm) hypothetical protein 0.0064 0.0009 0.001
Brugia malayi RhoGAP domain containing protein 0.0113 0.0434 0.0472
Loa Loa (eye worm) hypothetical protein 0.0157 0.0818 0.089
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0152 0.0767 0.0794
Brugia malayi Protein kinase domain containing protein 0.0982 0.7932 0.8632
Echinococcus granulosus calcium dependent protein kinase 0.0082 0.0163 0.0162
Brugia malayi Protein kinase domain containing protein 0.0211 0.1282 0.1395
Echinococcus multilocularis rac serine:threonine kinase 0.0193 0.1127 0.1371
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0278 0.1055
Echinococcus multilocularis c src tyrosine kinase 0.0159 0.0828 0.1007
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0063 0.0001 0.0001
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0194 0.1134 0.1233
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0278 0.1055
Loa Loa (eye worm) thyroid receptor interactor 0.0132 0.0595 0.0647
Loa Loa (eye worm) hypothetical protein 0.0098 0.0305 0.0332
Trichomonas vaginalis AGC family protein kinase 0.0368 0.2634 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0264 0.1739 0.2115
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0085 0.019 0.023
Loa Loa (eye worm) TK/FER protein kinase 0.0274 0.1826 0.1987
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Schistosoma mansoni hypothetical protein 0.0216 0.1324 0.1776
Echinococcus multilocularis neuropeptide s receptor 0.05 0.3768 0.4583
Echinococcus granulosus CDC7 cell division cycle 7 0.0105 0.0364 0.0363
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0098 0.0301 0.0404
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Leishmania major protein kinase, putative 0.0172 0.0941 0.1034
Echinococcus granulosus ephrin type A receptor 4 A 0.0132 0.0601 0.0601
Echinococcus granulosus titin 0.0078 0.0131 0.0131
Echinococcus granulosus tyrosine protein kinase Srms 0.0608 0.4702 0.4701
Echinococcus multilocularis mitogen activated protein kinase 11 0.0188 0.1082 0.1316
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0272 0.0365
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.01 0.0324 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0138 0.0647 0.0704
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0104 0.036 0.0234
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0264 0.1739 0.1739
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Brugia malayi Hr1 repeat family protein 0.0367 0.2625 0.2857
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0185 0.1054 0.1147
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0104 0.036 0.0361
Trypanosoma cruzi casein kinase, putative 0.0128 0.0559 0.0751
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0364 0.1381
Echinococcus granulosus tyrosine protein kinase Src42A 0.0264 0.1739 0.1739
Loa Loa (eye worm) TK/ABL protein kinase 0.0367 0.2627 0.2859
Schistosoma mansoni hypothetical protein 0.0063 0.0001 0.0001
Brugia malayi MAP kinase sur-1 0.0098 0.0301 0.0328
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0117 0.0471 0.0512
Entamoeba histolytica protein kinase, putative 0.0083 0.0171 0.0503
Onchocerca volvulus 0.0157 0.0818 0.1096
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.0471 0.1788
Echinococcus multilocularis geminin 0.0165 0.0879 0.1069
Loa Loa (eye worm) TK protein kinase 0.0224 0.139 0.1513
Schistosoma mansoni vam6/vps39 related 0.0134 0.0617 0.0828
Trypanosoma brucei polo-like protein kinase 0.0094 0.0272 0.0336
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0478 0.1816
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1324 0.1776
Echinococcus multilocularis cyclin dependent kinase 1 0.014 0.0665 0.0808
Schistosoma mansoni tensin 0.0063 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Trypanosoma cruzi cdc2-related kinase 3 0.014 0.0665 0.0891
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.036 0.1058
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0272 0.1033
Echinococcus granulosus mitogen activated protein kinase 14 0.0188 0.1082 0.1082
Echinococcus granulosus growth factor receptor bound protein 2 0.0106 0.037 0.037
Schistosoma mansoni vesicular amine transporter 0.0086 0.0203 0.0272
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0069 0.0058 0.0222
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0818 0.0864
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0216 0.1324 0.1323
Schistosoma mansoni shc transforming protein 0.0063 0.0001 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0534 0.0581
Schistosoma mansoni tensin-related 0.0063 0.0001 0.0001
Schistosoma mansoni SH2A 0.0063 0.0001 0.0001
Loa Loa (eye worm) TK/ROR protein kinase 0.1005 0.8126 0.8842
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.014 0.0665 0.0723
Echinococcus multilocularis 0.0209 0.1258 0.153
Schistosoma mansoni hypothetical protein 0.0122 0.0515 0.0691
Schistosoma mansoni tensin 0.0063 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0119 0.0484 0.0527
Plasmodium vivax protein kinase Crk2 0.014 0.0665 0.0775
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0272 0.1033
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.1134 0.1521
Trichomonas vaginalis AGC family protein kinase 0.0236 0.1494 0.5671
Loa Loa (eye worm) AGC/NDR protein kinase 0.0211 0.1282 0.1395
Brugia malayi probable protein kinase 0.0315 0.2178 0.2369
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.0941 0.1262
Brugia malayi Protein kinase domain containing protein 0.0097 0.0295 0.0321
Brugia malayi Immunoglobulin I-set domain containing protein 0.0078 0.0131 0.0143
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0718 0.5648 0.6146
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0152 0.0767 0.0834
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0097 0.0295 0.0144
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0272 0.0113
Schistosoma mansoni protein kinase 0.0518 0.3928 0.527
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0085 0.019 0.0255
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0272 0.08
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.01 0.0324 0.055
Loa Loa (eye worm) TK protein kinase 0.0316 0.2185 0.2378
Echinococcus multilocularis cyclin dependent kinase 0.014 0.0665 0.0808
Schistosoma mansoni cell adhesion molecule 0.0122 0.0515 0.0691
Loa Loa (eye worm) TK protein kinase 0.0161 0.0849 0.0924
Brugia malayi serine/threonine-protein kinase PAK 7 0.0276 0.1838 0.2
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.022 0.1358 0.1358
Echinococcus multilocularis mitogen activated protein kinase 3 0.0098 0.0301 0.0366
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0078 0.0132 0.016
Schistosoma mansoni serine/threonine kinase 0.0211 0.1282 0.172
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Brugia malayi Kinase associated domain 1 family protein 0.0122 0.0515 0.056
Trichomonas vaginalis AGC family protein kinase 0.0368 0.2634 1
Onchocerca volvulus 0.0118 0.0479 0.0642
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.01 0.0325 0.0324
Giardia lamblia Kinase, STE STE20 0.0099 0.0311 0.1395
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Trypanosoma cruzi aurora B kinase, putative 0.0172 0.0941 0.1262
Schistosoma mansoni tyrosine kinase 0.0159 0.0828 0.1111
Echinococcus granulosus protein kinase 0.0181 0.102 0.102
Onchocerca volvulus 0.0157 0.0818 0.1096
Echinococcus granulosus tar DNA binding protein 0.0125 0.0534 0.0533
Entamoeba histolytica protein kinase, putative 0.0082 0.0168 0.0492
Loa Loa (eye worm) hypothetical protein 0.0333 0.2335 0.254
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0274 0.1826 0.222
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0082 0.0168 0.0167
Schistosoma mansoni hypothetical protein 0.0165 0.0879 0.1179
Brugia malayi Variant SH3 domain containing protein 0.0103 0.035 0.0381
Echinococcus granulosus defective proboscis extension response 0.0086 0.0203 0.0202
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0085 0.019 0.023
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0818 0.089
Toxoplasma gondii microneme protein MIC17A 0.0157 0.0818 0.0864
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0178 0.0996 0.1084
Echinococcus multilocularis mitogen activated protein kinase 14 0.0188 0.1082 0.1316
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Onchocerca volvulus Slit protein homolog 0.0074 0.0094 0.0126
Echinococcus multilocularis nervana 2 0.0149 0.0741 0.09
Trypanosoma cruzi cdc2-related kinase 1 0.014 0.0665 0.0891
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0144 0.07 0.0762
Echinococcus granulosus geminin 0.0165 0.0879 0.0879
Loa Loa (eye worm) acetylcholinesterase 1 0.0077 0.012 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0534 0.0716
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0367 0.2627 0.3195
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0152 0.0767 0.1029
Brugia malayi phosphoinositide-dependent protein kinase I 0.0095 0.0278 0.0302
Schistosoma mansoni serine/threonine protein kinase 0.022 0.1358 0.1822
Echinococcus multilocularis PAK box P21 Rho binding 0.0074 0.01 0.0121
Echinococcus multilocularis tyrosine protein kinase Srms 0.0224 0.139 0.169
Schistosoma mansoni serine/threonine protein kinase 0.0311 0.2139 0.287
Brugia malayi Protein kinase domain containing protein 0.0118 0.0479 0.0521
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Plasmodium falciparum serine/threonine protein kinase, putative 0.0172 0.0941 0.1034
Plasmodium falciparum casein kinase 2, alpha subunit 0.0117 0.0471 0.0387
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0078 0.0131 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0118 0.0478 0.0581
Echinococcus multilocularis serine:threonine protein kinase 38 0.0211 0.1282 0.1559
Schistosoma mansoni protein kinase 0.0128 0.0559 0.0751
Leishmania major protein kinase, putative 0.0099 0.0311 0.0166
Schistosoma mansoni tyrosine kinase 0.0305 0.2086 0.2799
Echinococcus multilocularis expressed protein 0.0097 0.0295 0.0358
Echinococcus granulosus tyrosine protein kinase Src42A 0.0171 0.0932 0.0932
Echinococcus multilocularis nervana 2 0.0149 0.0741 0.09
Onchocerca volvulus 0.0078 0.0131 0.0175
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0094 0.0273 0.0114
Schistosoma mansoni tyrosine kinase 0.0539 0.4106 0.5509
Trichomonas vaginalis AGC family protein kinase 0.0368 0.2634 1
Echinococcus multilocularis expressed conserved protein 0.0159 0.0828 0.1007
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.036 0.0483
Toxoplasma gondii microneme protein MIC17C 0.0157 0.0818 0.0864
Echinococcus multilocularis serine:threonine protein kinase 0.0134 0.0616 0.0749
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.0767 0.291
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0518 0.3928 0.4778
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0159 0.0828 0.1007
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0118 0.0478 0.0581
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0104 0.0353 0.0352
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0171 0.0933 0.1134
Schistosoma mansoni serine/threonine protein kinase 0.047 0.3517 0.4718
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.1643 0.2204
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0211 0.1282 0.1559
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0437 0.3233 0.3932
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0152 0.0767 0.0766
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0216 0.1324 0.1441
Trichomonas vaginalis AGC family protein kinase 0.0368 0.2634 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0182 0.1025 0.1116
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0085 0.019 0.0255
Loa Loa (eye worm) hypothetical protein 0.0157 0.0818 0.089
Brugia malayi Protein kinase domain containing protein 0.0539 0.4106 0.4468
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0098 0.0301 0.0404
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0534 0.0716
Brugia malayi cytokine inducible SH2-containing protein 5 0.0063 0.0001 0.0001
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0063 0.0001 0.0001
Echinococcus multilocularis serine:threonine protein kinase 0.0134 0.0616 0.0749
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.01 0.0325 0.0324
Echinococcus granulosus mitogen activated protein kinase 0.0098 0.0301 0.0301
Schistosoma mansoni protein kinase 0.0437 0.3233 0.4337
Trypanosoma cruzi casein kinase, putative 0.0128 0.0559 0.0751
Loa Loa (eye worm) hypothetical protein 0.0068 0.0044 0.0048
Schistosoma mansoni tyrosine kinase 0.0441 0.3263 0.4377
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0128 0.0559 0.0609
Loa Loa (eye worm) hypothetical protein 0.0157 0.0818 0.089
Loa Loa (eye worm) TK protein kinase 0.0343 0.2421 0.2635
Onchocerca volvulus 0.0128 0.0559 0.075
Brugia malayi Furin-like cysteine rich region family protein 0.0734 0.579 0.6301
Schistosoma mansoni protein kinase 0.01 0.0325 0.0436
Brugia malayi Protein kinase domain containing protein 0.0118 0.0479 0.0521
Schistosoma mansoni serine/threonine kinase 0.0258 0.1681 0.2256
Echinococcus granulosus neuropeptide s receptor 0.05 0.3768 0.3768
Entamoeba histolytica protein kinase, putative 0.0152 0.0767 0.2256
Loa Loa (eye worm) hypothetical protein 0.0216 0.1324 0.1441
Echinococcus granulosus acetylcholinesterase 0.0077 0.012 0.0119
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0171 0.0932 0.1133
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Giardia lamblia Kinase, AGC AKT 0.0138 0.0647 0.527
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0264 0.1739 0.2115
Trichomonas vaginalis STE family protein kinase 0.01 0.0325 0.1233
Onchocerca volvulus 0.0387 0.2802 0.3758
Schistosoma mansoni tyrosine kinase 0.0484 0.3634 0.4875
Brugia malayi Immunoglobulin I-set domain containing protein 0.0316 0.2185 0.2378
Toxoplasma gondii PAN/Apple domain-containing protein 0.0157 0.0818 0.0864
Toxoplasma gondii microneme protein MIC4 0.0157 0.0818 0.0864
Loa Loa (eye worm) hypothetical protein 0.0126 0.0547 0.0595
Brugia malayi TAR-binding protein 0.0125 0.0534 0.0581
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0086 0.0203 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.07 0.0939
Loa Loa (eye worm) hypothetical protein 0.0107 0.0384 0.0418
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0371 0.0498
Echinococcus granulosus cGMP dependent protein kinase 0.0159 0.0828 0.0827
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0927 0.7454 1
Echinococcus granulosus casein kinase I gamma 0.0253 0.1643 0.1642
Schistosoma mansoni serine/threonine-protein kinase 0.0193 0.1127 0.1513
Toxoplasma gondii hypothetical protein 0.0157 0.0818 0.0864
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1324 0.1776
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0085 0.019 0.023
Echinococcus granulosus tyrosine protein kinase shark 0.0375 0.269 0.269
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0364 0.0488
Onchocerca volvulus 0.0927 0.7454 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0118 0.0478 0.0397
Loa Loa (eye worm) AGC/PKN protein kinase 0.0367 0.2625 0.2857
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0188 0.1082 0.1228
Schistosoma mansoni tyrosine kinase 0.0093 0.0263 0.0353
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0118 0.0478 0.0522
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0113 0.0434 0.0527
Brugia malayi serine/threonine kinase 12 0.0172 0.0941 0.1024
Brugia malayi hypothetical protein 0.023 0.1441 0.1568
Echinococcus granulosus cGMP dependent protein kinase 1 0.0159 0.0828 0.0827
Entamoeba histolytica protein kinase, putative 0.0083 0.0171 0.0503
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0368 0.2631 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.042 0.3086 0.4139
Echinococcus granulosus tissue type plasminogen activator 0.0927 0.7454 0.7454
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0264 0.1739 0.2115
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0085 0.019 0.0255
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0534 0.4065 0.4424
Loa Loa (eye worm) hypothetical protein 0.0118 0.0479 0.0521
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0185 0.1056 0.1417
Trichomonas vaginalis AGC family protein kinase 0.0172 0.0941 0.3571
Brugia malayi casein kinase 1, delta 0.0128 0.0559 0.0609
Echinococcus granulosus activin receptor type 0.0092 0.0254 0.0253
Entamoeba histolytica casein kinase, putative 0.0128 0.0559 0.1646
Echinococcus multilocularis NCK adaptor protein 0.0106 0.037 0.045
Schistosoma mansoni signal transduction protein lnk-related 0.0063 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.0471 0.1788
Brugia malayi Protein kinase domain containing protein 0.0437 0.3233 0.3518
Echinococcus multilocularis protein kinase c epsilon type 0.0263 0.1729 0.2102
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0095 0.0278 0.0302
Loa Loa (eye worm) hypothetical protein 0.0077 0.012 0.0131
Leishmania major protein kinase, putative 0.0118 0.0478 0.0397
Echinococcus granulosus serine:threonine protein kinase 0.0134 0.0616 0.0615
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0228 0.1425 0.1551
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0159 0.0828 0.1007
Entamoeba histolytica protein kinase, putative 0.0211 0.1282 0.3774
Schistosoma mansoni vav2 0.0121 0.0505 0.0678
Trypanosoma cruzi casein kinase, putative 0.0128 0.0559 0.0751
Schistosoma mansoni atypical protein kinase C 0.0368 0.2637 0.3538
Brugia malayi hypothetical protein 0.0216 0.1324 0.1441
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Giardia lamblia Aurora kinase 0.0172 0.0941 0.8668
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0224 0.139 0.169
Trypanosoma brucei cdc2-related kinase 1 0.014 0.0665 0.1941
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0818 0.089
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0118 0.0478 0.0397
Echinococcus granulosus NDR protein kinase 0.0211 0.1282 0.1282
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0077 0.012 0.0161
Echinococcus multilocularis insulin receptor 0.0539 0.4106 0.4995
Echinococcus multilocularis rho associated protein kinase 0.0387 0.2802 0.3407
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0718 0.5648 0.6146
Onchocerca volvulus 0.0077 0.0123 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0168 0.0225
Entamoeba histolytica protein kinase domain containing protein 0.0152 0.0767 0.2256
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0086 0.0203 0.0272
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0272 0.033
Brugia malayi Protein kinase c protein 2 0.0136 0.0632 0.0688
Onchocerca volvulus 0.0118 0.0479 0.0642
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0098 0.0301 0.0153
Onchocerca volvulus 0.0091 0.0244 0.0326
Schistosoma mansoni protein kinase 0.0172 0.0941 0.1262
Giardia lamblia Kinase, STE STE20 0.01 0.0325 0.1557
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0312 0.2153 0.2153
Brugia malayi STAT protein, DNA binding domain containing protein 0.0063 0.0001 0.0001
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0118 0.0478 0.0521
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Brugia malayi SH2 domain containing protein 0.0274 0.1826 0.1987
Loa Loa (eye worm) AGC/PKA protein kinase 0.0085 0.019 0.0207
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0144 0.07 0.2087
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0135 0.0621 0.0675
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1324 0.1776
Echinococcus multilocularis ephrin type A receptor 4 A 0.0132 0.0601 0.0731
Leishmania major casein kinase, putative 0.0128 0.0559 0.0509
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0534 0.0716
Plasmodium vivax tyrosine kinase-like protein, putative 0.0094 0.0273 0.0243
Onchocerca volvulus 0.0157 0.0818 0.1096
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0092 0.0254 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0559 0.0751
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0272 0.0272
Trichomonas vaginalis STE family protein kinase 0.0074 0.01 0.0381
Loa Loa (eye worm) hypothetical protein 0.0216 0.1324 0.1441
Echinococcus multilocularis protein kinase shaggy 0.0152 0.0767 0.0932
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0236 0.1494 0.1626
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0118 0.0478 0.0397
Loa Loa (eye worm) protein kinase domain-containing protein 0.0253 0.1643 0.1787
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.022 0.1358 0.1478
Loa Loa (eye worm) hypothetical protein 0.0077 0.0123 0.0134
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0211 0.1282 0.1282
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0152 0.0767 0.0834
Entamoeba histolytica protein kinase 2, putative 0.0185 0.1056 0.3109
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0324 0.1231
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0146 0.0718 0.0727
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0194 0.1134 0.1133
Onchocerca volvulus 0.0152 0.0767 0.1028
Loa Loa (eye worm) hypothetical protein 0.0071 0.0072 0.0078
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0085 0.019 0.0207
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0159 0.0828 0.1111
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1324 0.1776
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Echinococcus granulosus cyclin dependent kinase 5 0.014 0.0665 0.0664
Loa Loa (eye worm) hypothetical protein 0.0172 0.0947 0.103
Trypanosoma brucei protein kinase, putative 0.0092 0.0254 0.0261
Echinococcus multilocularis acetylcholinesterase 0.0077 0.012 0.0145
Echinococcus multilocularis mitogen activated protein kinase 0.0098 0.0301 0.0366
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.024 0.1533 0.1864
Giardia lamblia Kinase, CMGC MAPK 0.0098 0.0301 0.1284
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0185 0.1056 0.1284
Brugia malayi Trypsin family protein 0.0216 0.1324 0.1441
Brugia malayi Protein kinase domain containing protein 0.0118 0.0479 0.0521
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0536 0.408 0.4439
Entamoeba histolytica protein kinase, putative 0.0097 0.0295 0.0866
Echinococcus granulosus tyrosine protein kinase Blk 0.0224 0.139 0.139
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0161 0.0844 0.1019
Trichomonas vaginalis STE family protein kinase 0.01 0.0325 0.1233
Loa Loa (eye worm) carboxylesterase 0.0077 0.012 0.0131
Entamoeba histolytica protein kinase, putative 0.0368 0.2634 0.7757
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0128 0.0559 0.0751
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0364 0.1381
Entamoeba histolytica cell division protein kinase 2, putative 0.014 0.0665 0.1955
Leishmania major protein kinase, putative 0.0092 0.0254 0.0088
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.0787 0.0856
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0182 0.1025 0.1376
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0128 0.0559 0.0609
Echinococcus granulosus tyrosine protein kinase Fyn 0.0264 0.1739 0.1739
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0478 0.0642
Echinococcus granulosus Immunoglobulin 0.0086 0.0203 0.0202
Echinococcus granulosus homeodomain interacting protein kinase 3 0.024 0.1533 0.1532
Schistosoma mansoni titin 0.0078 0.0131 0.0176
Echinococcus granulosus Vam6:Vps39 protein 0.0134 0.0617 0.0616
Loa Loa (eye worm) RNA binding protein 0.0125 0.0534 0.0581
Entamoeba histolytica PH domain containing protein kinase, putative 0.0093 0.0261 0.0767
Echinococcus multilocularis casein kinase I alpha 0.0128 0.0559 0.068
Onchocerca volvulus 0.0148 0.0738 0.099
Loa Loa (eye worm) hypothetical protein 0.0143 0.0692 0.0753
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0118 0.0478 0.0478
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0591 0.4554 0.554
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.019 0.0255
Echinococcus granulosus cyclin dependent kinase 1 0.014 0.0665 0.0664
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0085 0.019 0.013
Brugia malayi Doublecortin family protein 0.0178 0.0996 0.1084
Loa Loa (eye worm) hypothetical protein 0.0216 0.1324 0.1441
Onchocerca volvulus 0.0216 0.1324 0.1775
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0152 0.0767 0.0794
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.1282 0.172
Trichomonas vaginalis CMGC family protein kinase 0.0182 0.1025 0.3892
Brugia malayi Protein kinase domain containing protein 0.0718 0.5648 0.6146
Echinococcus granulosus enteropeptidase 0.0216 0.1324 0.1323
Entamoeba histolytica protein kinase domain containing protein 0.01 0.0324 0.0953
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0063 0.0001 0.0001
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0264 0.1739 0.2115
Schistosoma mansoni hypothetical protein 0.0927 0.7454 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Schistosoma mansoni protein kinase 0.0229 0.1431 0.192
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0085 0.019 0.0189
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0113 0.0434 0.0472
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.014 0.0665 0.0653
Schistosoma mansoni nephrin 0.0127 0.0559 0.0749
Onchocerca volvulus 0.0157 0.0818 0.1096
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0152 0.0767 0.0932
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0211 0.1282 0.1559
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0094 0.0273 0.0114
Echinococcus granulosus protein kinase shaggy 0.0152 0.0767 0.0766
Loa Loa (eye worm) hypothetical protein 0.0134 0.0617 0.0671
Brugia malayi map kinase activated protein kinase protein 2 0.047 0.3517 0.3827
Trichomonas vaginalis CK1 family protein kinase 0.0128 0.0559 0.2124
Echinococcus multilocularis mitogen activated protein kinase 14 0.0188 0.1082 0.1316
Echinococcus granulosus tyrosine protein kinase 0.0343 0.2421 0.2421
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0188 0.1082 0.365
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0818 0.089
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0534 0.0581
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0279 0.1862 0.1861
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0104 0.036 0.0483
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0157 0.0818 0.0864
Brugia malayi SH2 domain containing protein 0.0063 0.0001 0.0001
Echinococcus multilocularis serine:threonine protein kinase 3 0.0305 0.2094 0.2547
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0131 0.0176
Loa Loa (eye worm) hypothetical protein 0.0085 0.019 0.0207
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0216 0.1324 0.1323
Plasmodium falciparum casein kinase 1 0.0128 0.0559 0.0509
Echinococcus multilocularis serine threonine protein kinase 0.026 0.1706 0.2075
Loa Loa (eye worm) AUR protein kinase 0.0172 0.0941 0.1024
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.0767 0.291
Echinococcus granulosus epidermal growth factor receptor 0.0734 0.579 0.579
Loa Loa (eye worm) hypothetical protein 0.0134 0.0617 0.0671
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0098 0.0301 0.0404
Toxoplasma gondii CMGC kinase, CK2 family 0.0117 0.0471 0.0387
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0134 0.0617 0.0828
Echinococcus granulosus tyrosine protein kinase ABL1 0.0367 0.2627 0.2627
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0117 0.0471 0.0512
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.01 0.0324 0.0185
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0159 0.0828 0.0878
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0254 0.0745
Onchocerca volvulus 0.0216 0.1324 0.1775
Brugia malayi Casein kinase II, alpha chain 0.0117 0.0471 0.0512
Echinococcus granulosus carboxylesterase 5A 0.0077 0.012 0.0119
Echinococcus multilocularis 0.0145 0.071 0.0862
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0095 0.0278 0.0277
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Brugia malayi Trypsin family protein 0.0216 0.1324 0.1441
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1128 0.919 1
Onchocerca volvulus 0.0157 0.0818 0.1096
Brugia malayi Protein kinase domain containing protein 0.0253 0.1643 0.1787
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0181 0.102 0.111
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0134 0.0617 0.0828
Loa Loa (eye worm) SH2 domain-containing protein 0.0063 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0303 0.2075 0.2784
Trichomonas vaginalis CAMK family protein kinase 0.0135 0.0626 0.2376
Schistosoma mansoni tyrosine kinase 0.0159 0.0828 0.1111
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0104 0.036 0.0234
Echinococcus multilocularis titin 0.0078 0.0131 0.0159
Loa Loa (eye worm) hypothetical protein 0.0333 0.2335 0.254
Echinococcus multilocularis glycoprotein Antigen 5 0.0216 0.1324 0.161
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0092 0.0254 0.0308
Brugia malayi hypothetical protein 0.0105 0.0365 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Echinococcus multilocularis calcium dependent protein kinase 0.0082 0.0163 0.0197
Brugia malayi Protein kinase domain containing protein 0.0134 0.0616 0.067
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.1729 0.2319
Entamoeba histolytica protein kinase domain containing protein 0.0152 0.0767 0.2256
Brugia malayi Protein kinase domain containing protein 0.0229 0.1431 0.1557
Echinococcus multilocularis activin receptor type 0.0092 0.0254 0.0308
Onchocerca volvulus Serine\/threonine kinase homolog 0.0194 0.1134 0.152
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0612 0.0821
Loa Loa (eye worm) hypothetical protein 0.0098 0.0304 0.033
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0098 0.0301 0.0153
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Entamoeba histolytica protein kinase , putative 0.0172 0.0941 0.2769
Schistosoma mansoni protein kinase 0.0092 0.0254 0.034
Loa Loa (eye worm) hypothetical protein 0.0145 0.071 0.0772
Loa Loa (eye worm) hypothetical protein 0.0104 0.036 0.0392
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0161 0.0844 0.09
Onchocerca volvulus 0.0118 0.0479 0.0642
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0368 0.2631 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0264 0.1739 0.2115
Onchocerca volvulus 0.0157 0.0818 0.1096
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0099 0.0311 0.0913
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0272 0.1033
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Loa Loa (eye worm) SH2 domain-containing protein 0.0063 0.0001 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0276 0.1841 0.2003
Loa Loa (eye worm) hypothetical protein 0.0545 0.4157 0.4524
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0118 0.0478 0.0521
Plasmodium falciparum enoyl-acyl carrier reductase 0.0368 0.2631 0.336
Echinococcus multilocularis casein kinase I alpha 0.0128 0.0559 0.068
Trypanosoma cruzi cdc2-related kinase 1 0.014 0.0665 0.0891
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0185 0.1056 0.1056
Echinococcus granulosus casein kinase I alpha 0.0128 0.0559 0.0559
Echinococcus multilocularis casein kinase I gamma 0.0253 0.1643 0.1997
Brugia malayi Fes/CIP4 homology domain containing protein 0.0132 0.0595 0.0647
Giardia lamblia Kinase, CMGC DYRK 0.01 0.0324 0.1551
Echinococcus multilocularis CDC7 cell division cycle 7 0.0105 0.0364 0.0442
Brugia malayi SH2 domain containing protein 0.0063 0.0001 0.0001
Schistosoma mansoni protein kinase 0.0518 0.3928 0.527
Trichomonas vaginalis AGC family protein kinase 0.0172 0.0941 0.3571
Entamoeba histolytica PH domain containing protein kinase, putative 0.0193 0.1127 0.3319
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0256 0.1671 0.2032
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0238 0.1513 0.1512
Trypanosoma cruzi Protein kinase B 0.0193 0.1127 0.1513
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Entamoeba histolytica protein kinase, putative 0.0097 0.0295 0.0866
Echinococcus granulosus mitogen activated protein kinase 3 0.0098 0.0301 0.0301
Entamoeba histolytica hypothetical protein 0.0144 0.07 0.206
Leishmania major hypothetical protein, conserved 0.0927 0.7454 1
Giardia lamblia Kinase, CMGC CDK 0.014 0.0665 0.5478
Entamoeba histolytica protein kinase domain containing protein 0.0144 0.07 0.206
Echinococcus granulosus glycoprotein Antigen 5 0.0216 0.1324 0.1323
Echinococcus multilocularis mitogen activated protein kinase 11 0.0188 0.1082 0.1316
Onchocerca volvulus 0.0333 0.2335 0.3131
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0534 0.0716
Loa Loa (eye worm) hypothetical protein 0.0216 0.1324 0.1441
Echinococcus multilocularis protein kinase c iota type 0.0361 0.2574 0.3131
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Trypanosoma cruzi hypothetical protein, conserved 0.0927 0.7454 1
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.1681 0.6382
Entamoeba histolytica protein kinase, putative 0.0144 0.07 0.206
Entamoeba histolytica cell division protein kinase 2, putative 0.014 0.0665 0.1955
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Trichomonas vaginalis AGC family protein kinase 0.0368 0.2634 1
Entamoeba histolytica casein kinase, putative 0.0117 0.0471 0.1385
Echinococcus multilocularis epidermal growth factor receptor 0.0484 0.3634 0.442
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0188 0.1082 0.1452
Echinococcus multilocularis tyrosine protein kinase 0.0343 0.2421 0.2945
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Brugia malayi SH2 domain containing protein 0.0063 0.0001 0.0001
Echinococcus multilocularis dual specificity 0.0144 0.07 0.0851
Brugia malayi SH2 domain containing protein 0.0063 0.0001 0.0001
Echinococcus granulosus casein kinase I delta 0.0128 0.0559 0.0559
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0294 0.1992 0.2422
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0276 0.1838 0.2
Echinococcus granulosus serine:threonine protein kinase 3 0.0305 0.2094 0.2094
Loa Loa (eye worm) trypsin family protein 0.0216 0.1324 0.1441
Echinococcus granulosus nervana 2 0.0149 0.0741 0.074
Loa Loa (eye worm) hypothetical protein 0.0126 0.0547 0.0595
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Entamoeba histolytica protein kinase, putative 0.012 0.0492 0.1446
Loa Loa (eye worm) hypothetical protein 0.0157 0.0818 0.089
Loa Loa (eye worm) hypothetical protein 0.0104 0.0353 0.0384
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Loa Loa (eye worm) casein kinase 0.0216 0.1327 0.1444
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Brugia malayi hypothetical protein 0.0068 0.0044 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0831 0.1114
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0134 0.0616 0.067
Trypanosoma cruzi casein kinase, putative 0.0128 0.0559 0.0751
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.024 0.1533 0.1668
Brugia malayi intracellular kinase 0.0152 0.0767 0.0834
Schistosoma mansoni protein kinase 0.01 0.0325 0.0436
Onchocerca volvulus 0.0216 0.1324 0.1775
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0272 0.1033
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0091 0.0244 0.0327
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0118 0.0478 0.118
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0085 0.019 0.0255
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0229 0.1431 0.1557
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0113 0.0434 0.0582
Echinococcus multilocularis epidermal growth factor receptor 0.0734 0.579 0.7043
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.022 0.1358 0.1652
Schistosoma mansoni nck2/grb4 0.0103 0.035 0.0469
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0294 0.1992 0.1991
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0484 0.0527
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0368 0.2631 0.336
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0099 0.0311 0.0494
Echinococcus multilocularis tyrosine protein kinase Blk 0.0224 0.139 0.169
Echinococcus multilocularis carboxylesterase 5A 0.0077 0.012 0.0145
Toxoplasma gondii aurora kinase 0.0172 0.0941 0.1034
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0264 0.1739 0.2115
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0324 0.0435
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0082 0.0168 0.0167
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0368 0.2631 0.3446
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0113 0.0434 0.0433
Echinococcus granulosus cGMP dependent protein kinase 1 0.0159 0.0828 0.0827
Loa Loa (eye worm) AUR protein kinase 0.0172 0.0941 0.1024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0118 0.0478 0.0478
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0314 0.2171 0.264
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0818 0.0864
Brugia malayi Temporarily assigned gene name protein 59 0.0155 0.0796 0.0866
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0558 0.4269 0.5192
Schistosoma mansoni kinase 0.0229 0.1431 0.192
Plasmodium falciparum NIMA related kinase 1 0.0161 0.0844 0.09
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0172 0.0941 0.115
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0118 0.0478 0.0522
Brugia malayi Protein kinase domain containing protein 0.0238 0.1513 0.1647
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0324 0.1231
Loa Loa (eye worm) hypothetical protein 0.0718 0.5648 0.6146
Entamoeba histolytica protein kinase, putative 0.0172 0.0941 0.2769
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0118 0.0478 0.0397
Echinococcus multilocularis tissue type plasminogen activator 0.0927 0.7454 0.9067
Loa Loa (eye worm) AGC/AKT protein kinase 0.0368 0.2634 0.2867
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0264 0.1739 0.2115
Echinococcus granulosus titin 0.0078 0.0131 0.0131
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0082 0.0168 0.0203
Echinococcus granulosus transmembrane protease serine 3 0.0216 0.1324 0.1323
Loa Loa (eye worm) hypothetical protein 0.0098 0.0305 0.0332
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.1513 0.203
Entamoeba histolytica protein kinase, putative 0.036 0.2563 0.7547
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0113 0.0434 0.0582
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0216 0.1324 0.1776
Schistosoma mansoni serine/threonine protein kinase 0.024 0.1533 0.2056
Echinococcus granulosus dual specificity 0.01 0.0324 0.0324
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0171 0.0934 0.0933
Brugia malayi Protein kinase domain containing protein 0.0071 0.0075 0.0081
Trypanosoma brucei cdc2-related kinase 3 0.014 0.0665 0.1941
Trichomonas vaginalis STE family protein kinase 0.0161 0.0844 0.3204
Brugia malayi RNA binding protein 0.0125 0.0534 0.0581
Entamoeba histolytica protein kinase, putative 0.0144 0.07 0.206
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0665 0.0891
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.0471 0.1788
Schistosoma mansoni protein kinase 0.0518 0.3928 0.527
Loa Loa (eye worm) SH2 domain-containing protein 0.0063 0.0001 0.0001
Echinococcus granulosus tyrosine kinase 0.0118 0.0479 0.0478
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0182 0.1025 0.3417
Plasmodium vivax unspecified product 0.0117 0.0471 0.0512
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.014 0.0665 0.0653
Trichomonas vaginalis AGC family protein kinase 0.0172 0.0941 0.3571
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0092 0.0254 0.034
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.042 0.3086 0.3753
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Echinococcus multilocularis protein tyrosine kinase 0.0663 0.518 0.6301
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.047 0.3517 0.4278
Echinococcus multilocularis casein kinase I delta 0.0128 0.0559 0.068
Giardia lamblia Kinase, CDC7 0.0105 0.0364 0.2005
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0182 0.1025 0.3417
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.0295 0.0144
Brugia malayi Tyrosine-protein kinase abl-1 0.0254 0.165 0.1795
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0295 0.0395
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0171 0.0934 0.1135
Echinococcus granulosus casein kinase I alpha 0.0128 0.0559 0.0559
Brugia malayi Protein kinase domain containing protein 0.0671 0.5243 0.5705
Entamoeba histolytica protein kinase, putative 0.0074 0.01 0.0293
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0118 0.0478 0.0522
Echinococcus granulosus N chimaerin 0.0113 0.0434 0.0433
Echinococcus multilocularis growth factor receptor bound protein 2 0.0103 0.035 0.0425
Giardia lamblia Kinase, CMGC CK2 0.0117 0.0471 0.3243
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.2153 0.2889
Echinococcus multilocularis myosin iiia 0.0099 0.0311 0.0377
Schistosoma mansoni tyrosine kinase 0.0264 0.1739 0.2333
Schistosoma mansoni tyrosine kinase 0.0264 0.1739 0.2333
Echinococcus granulosus dual specificity protein kinase clk2 0.0182 0.1025 0.1025
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0182 0.1025 0.115
Entamoeba histolytica hypothetical protein 0.0456 0.3396 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0368 0.2631 0.5
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0188 0.1082 0.1452
Loa Loa (eye worm) hypothetical protein 0.0216 0.1324 0.1441
Echinococcus granulosus insulin receptor 0.0539 0.4106 0.4106
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.036 0.2563 0.2789
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.0471 0.1788
Loa Loa (eye worm) AGC/PKG protein kinase 0.0159 0.0828 0.0901
Plasmodium vivax serine/threonine protein kinase, putative 0.0097 0.0295 0.0272
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0272 0.0365
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0818 0.0864
Brugia malayi Serine/threonine-protein kinase SULU 0.0264 0.1735 0.1888
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.01 0.0324 0.0435
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.01 0.0325 0.0394
Entamoeba histolytica protein kinase domain containing protein 0.024 0.1533 0.4512
Toxoplasma gondii subtilisin SUB12 0.0157 0.0818 0.0864
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0185 0.1054 0.1147
Onchocerca volvulus 0.0375 0.2694 0.3613
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0818 0.0864
Trichomonas vaginalis STE family protein kinase 0.01 0.0325 0.1233
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0216 0.1324 0.161
Brugia malayi C1-like domain containing protein 0.0185 0.1054 0.1147
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Giardia lamblia Kinase, AGC PKA 0.0185 0.1056 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0203 0.022
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0134 0.0617 0.0616
Entamoeba histolytica p21-activated kinase 0.0109 0.0396 0.1165
Schistosoma mansoni serine/threonine-protein kinase 0.0193 0.1127 0.1513
Plasmodium falciparum protein serine/threonine kinase-1 0.0182 0.1025 0.115
Echinococcus granulosus casein kinase i 0.0128 0.0559 0.0559
Schistosoma mansoni serine/threonine protein kinase 0.042 0.3086 0.414
Loa Loa (eye worm) hypothetical protein 0.0107 0.0384 0.0418
Onchocerca volvulus 0.0157 0.0809 0.1085
Echinococcus multilocularis casein kinase i 0.0128 0.0559 0.068
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0264 0.1739 0.1739
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0104 0.036 0.0392
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0182 0.1025 0.1376
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0103 0.035 0.0469
Giardia lamblia Kinase, CK1 Casein kinase 0.0128 0.0559 0.4265
Brugia malayi Temporarily assigned gene name protein 59 0.0134 0.0617 0.0671
Brugia malayi P38 map kinase family protein 2 0.0188 0.1082 0.1177
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0149 0.0741 0.09
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.019 0.0255
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0324 0.1231
Echinococcus multilocularis dual specificity 0.01 0.0324 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.019 0.0255
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0063 0.0001 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0534 0.0649
Entamoeba histolytica protein kinase, putative 0.0118 0.0478 0.1407
Trichomonas vaginalis AGC family protein kinase 0.0368 0.2634 1
Entamoeba histolytica protein kinase, putative 0.0095 0.0278 0.0816
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0085 0.019 0.0189
Plasmodium falciparum cysteine repeat modular protein 1 0.0927 0.7454 1
Schistosoma mansoni tyrosine kinase 0.0429 0.3156 0.4234
Loa Loa (eye worm) hypothetical protein 0.0122 0.0515 0.056
Trichomonas vaginalis STE family protein kinase 0.0099 0.0311 0.118
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0092 0.0254 0.034
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0188 0.1082 0.1177
Giardia lamblia Kinase, PLK 0.0094 0.0272 0.0948
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0294 0.1992 0.2422
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0103 0.035 0.0381
Schistosoma mansoni tyrosine kinase 0.0095 0.0282 0.0378
Brugia malayi Protein kinase domain containing protein 0.0144 0.07 0.0762
Giardia lamblia Kinase, CAMK CAMKL 0.0104 0.036 0.1962
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.1025 0.1376
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Echinococcus granulosus tyrosine protein kinase Src64B 0.0264 0.1739 0.1739
Schistosoma mansoni ephrin receptor 0.0074 0.01 0.0135
Schistosoma mansoni tyrosine kinase 0.0429 0.3156 0.4234
Echinococcus granulosus neuropeptide receptor A26 0.05 0.3768 0.3768
Loa Loa (eye worm) hypothetical protein 0.0074 0.0094 0.0103
Plasmodium falciparum serine/threonine protein kinase KIN 0.0104 0.036 0.0234
Echinococcus multilocularis tyrosine kinase 0.0118 0.0479 0.0582
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0437 0.3233 0.3232
Echinococcus granulosus Glutaredoxin protein 5 0.0149 0.0741 0.074
Brugia malayi Serine/threonine-protein kinase Pim-3 0.042 0.3086 0.3358
Echinococcus multilocularis raf serine:threonine protein kinase 0.0106 0.0371 0.0451
Brugia malayi protein kinase C3,putative 0.0186 0.1067 0.1161
Echinococcus granulosus neuroglian 0.0109 0.0396 0.0396
Onchocerca volvulus 0.0105 0.0364 0.0487
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.0471 0.1385
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0118 0.0478 0.0581
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0272 0.1033
Loa Loa (eye worm) hypothetical protein 0.0288 0.1943 0.2114
Schistosoma mansoni rap gtpase-activating protein 0.0134 0.0617 0.0828
Loa Loa (eye worm) hypothetical protein 0.0333 0.2335 0.254
Plasmodium vivax serine/threonine kinase-1, putative 0.0182 0.1025 0.1265
Loa Loa (eye worm) hypothetical protein 0.0087 0.0206 0.0224
Echinococcus multilocularis tyrosine protein kinase HCK 0.0161 0.0849 0.1032
Echinococcus granulosus mitogen activated protein kinase 11 0.0188 0.1082 0.1082
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0272 0.1033
Echinococcus multilocularis calcium activated potassium channel 0.0159 0.0831 0.101
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0828 0.1111
Echinococcus multilocularis enteropeptidase 0.0216 0.1324 0.161
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0301 0.1144
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0324 0.1231
Brugia malayi protein unc-22 0.0078 0.0131 0.0143
Brugia malayi Variant SH3 domain containing protein 0.0073 0.0085 0.0092
Schistosoma mansoni protein kinase C mu 0.0185 0.1054 0.1414
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.1735 0.2328
Trichomonas vaginalis CK1 family protein kinase 0.0128 0.0559 0.2124
Brugia malayi Carboxylesterase family protein 0.0077 0.012 0.0131
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.1868 0.2506
Loa Loa (eye worm) hypothetical protein 0.0219 0.1347 0.1466
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0324 0.1231
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0095 0.0278 0.0337
Brugia malayi Protein kinase domain containing protein 0.0095 0.0278 0.0302
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Echinococcus multilocularis tyrosine protein kinase shark 0.0375 0.269 0.3272
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1671 0.2242
Schistosoma mansoni protein kinase 0.0117 0.0471 0.0632
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0264 0.1739 0.2115
Entamoeba histolytica protein kinase, putative 0.0082 0.0168 0.0492
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0199 0.1178 0.4473
Plasmodium falciparum calcium-dependent protein kinase 3 0.0118 0.0478 0.0397
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0099 0.0311 0.0417
Plasmodium falciparum protein kinase, putative 0.0092 0.0254 0.0088
Onchocerca volvulus 0.0098 0.0305 0.0408
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0171 0.0933 0.0932
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.01 0.0324 0.0353
Brugia malayi Protein kinase domain containing protein 0.0105 0.0364 0.0396
Echinococcus granulosus protein tyrosine kinase 0.0663 0.518 0.518
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.1868 0.2506
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0134 0.0617 0.1747
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0272 0.0296
Toxoplasma gondii microneme protein MIC17B 0.0157 0.0818 0.0864
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0098 0.0301 0.0328
Echinococcus granulosus dual specificity 0.01 0.0324 0.0324
Brugia malayi Homeodomain interacting protein kinase protein 1 0.024 0.1533 0.1668
Loa Loa (eye worm) STAT protein 0.0063 0.0001 0.0001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0518 0.3928 0.3928
Echinococcus granulosus roundabout 2 0.0145 0.0709 0.0708
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.04 0.2909 0.3166
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0264 0.1735 0.1735
Entamoeba histolytica PH domain containing protein kinase, putative 0.0093 0.0261 0.0767
Entamoeba histolytica protein kinase, putative 0.0099 0.0316 0.093
Echinococcus granulosus tyrosine kinase 0.0224 0.139 0.139
Loa Loa (eye worm) SRC-1 0.0264 0.1739 0.1893
Trichomonas vaginalis AGC family protein kinase 0.0085 0.019 0.0721
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0272 0.1033
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0301 0.1144
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0095 0.0278 0.0302
Trichomonas vaginalis STE family protein kinase 0.01 0.0325 0.1233
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0128 0.0559 0.0609
Schistosoma mansoni tyrosine kinase 0.0429 0.3156 0.4234
Plasmodium vivax calcium-dependent protein kinase, putative 0.0118 0.0478 0.0522
Schistosoma mansoni GTPase activating protein 0.0063 0.0001 0.0001
Giardia lamblia Kinase, CMGC CDK 0.014 0.0665 0.5478
Echinococcus granulosus serine:threonine protein kinase N2 0.0156 0.0803 0.0802
Echinococcus granulosus Protein kinase C brain isozyme 0.0311 0.2139 0.2139
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0301 0.1144
Echinococcus multilocularis cyclin dependent kinase 1 0.014 0.0665 0.0808
Brugia malayi SH2 domain containing protein 0.0063 0.0001 0.0001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1324 0.1776
Echinococcus granulosus tyrosine protein kinase Fyn 0.0264 0.1739 0.1739
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.01 0.0325 0.0324
Brugia malayi follicle stimulating hormone receptor 0.0276 0.1841 0.2003
Schistosoma mansoni protein kinase 0.0181 0.102 0.1369
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0301 0.0404
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0103 0.035 0.0381
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0172 0.0941 0.2769
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0278 0.0373
Entamoeba histolytica protein kinase, putative 0.0172 0.0941 0.2769
Trypanosoma brucei rac serine-threonine kinase, putative 0.0368 0.2634 1
Plasmodium falciparum serine/threonine protein kinase 0.0097 0.0295 0.0144
Loa Loa (eye worm) TK/EPH protein kinase 0.0153 0.0783 0.0852
Plasmodium vivax glycogen synthase kinase 3, putative 0.0152 0.0767 0.0914
Onchocerca volvulus 0.0216 0.1324 0.1775
Brugia malayi Protein kinase domain containing protein 0.0118 0.0479 0.0521
Entamoeba histolytica protein kinase, putative 0.01 0.0325 0.0955
Schistosoma mansoni tyrosine kinase 0.0294 0.1992 0.2672
Brugia malayi cell division control protein 2 homolog 0.014 0.0665 0.0723
Echinococcus multilocularis Immunoglobulin 0.0086 0.0203 0.0246
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0099 0.0316 0.093
Echinococcus multilocularis roundabout 2 0.0145 0.0709 0.0861
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0258 0.1681 0.1829
Schistosoma mansoni ste20-related kinase 0.0243 0.1559 0.2091
Brugia malayi Protein kinase domain containing protein 0.0718 0.5648 0.6146
Toxoplasma gondii hypothetical protein 0.0157 0.0818 0.0864
Echinococcus multilocularis serine:threonine protein kinase N2 0.0156 0.0803 0.0976
Echinococcus multilocularis neuropeptide receptor A26 0.05 0.3768 0.4583
Loa Loa (eye worm) hypothetical protein 0.0157 0.0818 0.089
Toxoplasma gondii AGC kinase 0.036 0.2563 0.3267
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Giardia lamblia Kinase, CMGC SRPK 0.0097 0.0295 0.1209
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.022 0.1358 0.1478
Brugia malayi ephrin receptor 1 precursor 0.0092 0.0251 0.0273
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Echinococcus granulosus epidermal growth factor receptor 0.0484 0.3634 0.3634
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0264 0.1735 0.211
Echinococcus granulosus serine:threonine kinase SAD 1 0.0104 0.036 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0364 0.1381
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0104 0.036 0.0437
Brugia malayi tRNA modification GTPase TrmE family protein 0.0063 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0314 0.2171 0.2362
Brugia malayi Protein kinase domain containing protein 0.042 0.3086 0.3358
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0092 0.0254 0.0088
Brugia malayi Immunoglobulin I-set domain containing protein 0.0534 0.4065 0.4424
Brugia malayi SH2 domain containing protein 0.0063 0.0001 0.0001
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0305 0.2094 0.2279
Echinococcus granulosus rho-associated protein kinase 1 0.0387 0.2802 0.2801
Schistosoma mansoni tyrosine kinase 0.0484 0.3634 0.4875
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0264 0.1735 0.1888
Schistosoma mansoni serine/threonine protein kinase 0.057 0.4374 0.5868
Loa Loa (eye worm) hypothetical protein 0.0219 0.1347 0.1466
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0098 0.0301 0.0455
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0818 0.0864
Brugia malayi serine/threonine-protein kinase 6 0.0172 0.0941 0.1024
Schistosoma mansoni tensin-related 0.0063 0.0001 0.0001
Toxoplasma gondii kringle domain-containing protein 0.0927 0.7454 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0182 0.1025 0.1376
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0092 0.0254 0.0261
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0665 0.2522
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0424 0.312 0.3396
Toxoplasma gondii PAN domain-containing protein 0.0157 0.0818 0.0864
Loa Loa (eye worm) AGC/PKA protein kinase 0.0085 0.019 0.0207
Schistosoma mansoni hypothetical protein 0.0122 0.0515 0.0691
Loa Loa (eye worm) hypothetical protein 0.0134 0.0617 0.0671
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Brugia malayi p70 ribosomal S6 kinase beta 0.036 0.2563 0.2789
Echinococcus multilocularis hypothetical protein 0.0122 0.0515 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0009 0.0035
Echinococcus granulosus dual specificity 0.0144 0.07 0.0699
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0069 0.0058 0.0222
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0078 0.0132 0.0131
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.047 0.3517 0.3827
Echinococcus granulosus cyclin dependent kinase 0.014 0.0665 0.0664
Loa Loa (eye worm) hypothetical protein 0.0216 0.1324 0.1441
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Echinococcus multilocularis tyrosine protein kinase Abl 0.0254 0.165 0.2006
Schistosoma mansoni serine/threonine protein kinase 0.0314 0.2171 0.2913
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0368 0.2631 0.5
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0135 0.0626 0.0761
Loa Loa (eye worm) hypothetical protein 0.0216 0.1324 0.1441
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.04 0.2909 0.3166
Brugia malayi Protein kinase domain containing protein 0.0536 0.408 0.4439
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0828 0.1111
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0818 0.089
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0279 0.1868 0.2272
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0118 0.0478 0.0521
Brugia malayi SH2 domain containing protein 0.0118 0.0479 0.0521
Trichomonas vaginalis AGC family protein kinase 0.0161 0.0844 0.3204
Trichomonas vaginalis CK1 family protein kinase 0.0128 0.0559 0.2124
Loa Loa (eye worm) hypothetical protein 0.0148 0.0738 0.0803
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0149 0.0741 0.074
Trypanosoma brucei protein kinase, putative 0.0098 0.0301 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0311 0.2139 0.287
Brugia malayi Egg laying defective protein 4 0.0159 0.0828 0.0901
Schistosoma mansoni hypothetical protein 0.0134 0.0617 0.0828
Echinococcus granulosus calcium activated potassium channel 0.0159 0.0831 0.083
Plasmodium falciparum protein kinase 5 0.014 0.0665 0.0653
Brugia malayi Protein kinase domain containing protein 0.0258 0.1681 0.1829
Schistosoma mansoni protein kinase 0.0092 0.0254 0.034
Brugia malayi Protein kinase domain containing protein 0.034 0.2388 0.2599
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0272 0.0364
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0274 0.1826 0.1825
Onchocerca volvulus 0.0118 0.0479 0.0642
Toxoplasma gondii histone kinase SNF1, putative 0.0104 0.036 0.0234
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0172 0.0941 0.2769
Echinococcus granulosus expressed protein 0.0097 0.0295 0.0294
Brugia malayi Protein kinase domain containing protein 0.014 0.0665 0.0723
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0134 0.0617 0.0828
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0097 0.0295 0.0321
Schistosoma mansoni suppressor of cytokine signaling 0.0063 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0068 0.0044 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1324 0.1776
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0368 0.2631 0.5
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0185 0.1056 0.1192
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0097 0.0295 0.0395
Onchocerca volvulus 0.0118 0.0479 0.0642
Echinococcus granulosus casein kinase ii subunit alpha 0.0117 0.0471 0.047
Echinococcus multilocularis death associated protein kinase 1 0.1016 0.8221 1
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.0471 0.1788
Echinococcus multilocularis casein kinase ii subunit alpha 0.0117 0.0471 0.0572
Echinococcus multilocularis casein kinase I delta 0.0128 0.0559 0.068
Echinococcus multilocularis dual specificity protein kinase clk2 0.0182 0.1025 0.1247
Brugia malayi Cam kinase protein 1 0.0118 0.0478 0.0521
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Onchocerca volvulus 0.0157 0.0818 0.1096
Echinococcus granulosus hypothetical protein 0.0145 0.071 0.0709
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0301 0.1144
Echinococcus granulosus nervana 2 0.0149 0.0741 0.074
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.014 0.0665 0.0664
Brugia malayi hypothetical protein 0.0264 0.1735 0.1888
Onchocerca volvulus 0.0157 0.0818 0.1096
Schistosoma mansoni tyrosine kinase 0.0734 0.579 0.7768
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.1671 0.2242
Echinococcus granulosus tyrosine protein kinase Lyn 0.0301 0.2055 0.2054
Echinococcus multilocularis N chimaerin 0.0113 0.0434 0.0527
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0616 0.2338
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0211 0.1282 0.1282
Trypanosoma brucei SNF1-related protein kinases, putative 0.0104 0.036 0.0695
Brugia malayi Protein kinase domain containing protein 0.0118 0.0479 0.0521
Loa Loa (eye worm) hypothetical protein 0.0103 0.035 0.0381
Echinococcus granulosus tyrosine protein kinase HCK 0.0161 0.0849 0.0849
Loa Loa (eye worm) hypothetical protein 0.0157 0.0809 0.0881
Loa Loa (eye worm) hypothetical protein 0.0151 0.0759 0.0826
Echinococcus multilocularis transmembrane protease serine 3 0.0216 0.1324 0.161
Giardia lamblia Kinase, CMGC GSK 0.0152 0.0767 0.6657
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1324 0.1776
Giardia lamblia Kinase, NEK 0.0161 0.0844 0.7551
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0831 0.1114
Loa Loa (eye worm) hypothetical protein 0.0134 0.0617 0.0671
Loa Loa (eye worm) hypothetical protein 0.0105 0.0365 0.0397
Onchocerca volvulus 0.0105 0.0364 0.0487
Echinococcus multilocularis 0.0181 0.102 0.124
Entamoeba histolytica protein kinase, putative 0.0161 0.0849 0.2499
Brugia malayi hypothetical protein 0.0118 0.0479 0.0521
Entamoeba histolytica protein kinase domain containing protein 0.0172 0.0941 0.2769
Onchocerca volvulus 0.0216 0.1324 0.1775
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0484 0.0527
Onchocerca volvulus 0.0077 0.0125 0.0166
Trypanosoma brucei protein kinase, putative 0.0152 0.0767 0.2359
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0194 0.113 0.123
Loa Loa (eye worm) hypothetical protein 0.0384 0.2768 0.3012
Loa Loa (eye worm) hypothetical protein 0.0103 0.0349 0.038
Echinococcus multilocularis cyclin dependent kinase 5 0.014 0.0665 0.0808
Brugia malayi Fibronectin type III domain containing protein 0.0105 0.0365 0.0397
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.01 0.0325 0.0394
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0104 0.036 0.0483
Entamoeba histolytica casein kinase 1, putative 0.0128 0.0559 0.1646
Schistosoma mansoni tensin 0.0063 0.0001 0.0001
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0118 0.0479 0.1409
Brugia malayi hypothetical protein 0.0134 0.0617 0.0671
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0085 0.019 0.0189
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0194 0.1134 0.1378
Loa Loa (eye worm) AUR protein kinase 0.0172 0.0941 0.1024
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0099 0.0311 0.0417
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0272 0.0296
Brugia malayi Protein kinase domain containing protein 0.0236 0.1494 0.1626
Loa Loa (eye worm) hypothetical protein 0.023 0.1441 0.1568
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Plasmodium vivax casein kinase 1, putative 0.0128 0.0559 0.0632
Brugia malayi Sex muscle abnormal protein 5 0.0103 0.035 0.0381
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0095 0.0282 0.0306
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0172 0.0941 0.094
Brugia malayi EGF-like domain containing protein 0.0074 0.0094 0.0103
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Echinococcus granulosus c-Jun N-terminal kinases 0.0314 0.2171 0.2171
Giardia lamblia Kinase, CAMK CAMKL 0.0104 0.036 0.1962
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0104 0.036 0.0695
Loa Loa (eye worm) PAN domain-containing protein 0.0157 0.0818 0.089
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0144 0.07 0.0939
Leishmania major casein kinase II, putative 0.0117 0.0471 0.0387
Plasmodium falciparum calcium-dependent protein kinase 2 0.0118 0.0478 0.0397
Loa Loa (eye worm) TK protein kinase 0.0212 0.1285 0.1398
Loa Loa (eye worm) hypothetical protein 0.0077 0.012 0.0131
Loa Loa (eye worm) CAMK/PIM protein kinase 0.042 0.3086 0.3358
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0172 0.0941 0.2769
Echinococcus granulosus serine:threonine protein kinase N2 0.0367 0.2625 0.2625
Trichomonas vaginalis AGC family protein kinase 0.0244 0.1565 0.5942
Schistosoma mansoni tyrosine kinase 0.0539 0.4106 0.5509
Giardia lamblia Kinase, CMGC GSK 0.0152 0.0767 0.6657
Entamoeba histolytica protein kinase, putative 0.0368 0.2634 0.7757
Echinococcus granulosus dual specificity 0.01 0.0324 0.0324
Brugia malayi Protein kinase domain containing protein 0.0182 0.1025 0.1116
Echinococcus granulosus raf serine:threonine protein kinase 0.0106 0.0371 0.0371
Brugia malayi Protein kinase domain containing protein 0.0194 0.1134 0.1233
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1324 0.161
Trypanosoma brucei Casein kinase II 0.0117 0.0471 0.1149
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0063 0.0001 0.0001
Echinococcus granulosus serine/threonine protein kinase 0.0193 0.1127 0.1127
Leishmania major protein kinase, putative 0.0182 0.1025 0.115
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0831 0.1114
Trypanosoma brucei aurora B kinase 0.0172 0.0941 0.3072
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0324 0.1231
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1441 0.144
Brugia malayi SRC-1 0.0264 0.1739 0.1893
Schistosoma mansoni protein kinase 0.0315 0.2178 0.2921
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0312 0.2153 0.2619
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0098 0.0301 0.0153
Loa Loa (eye worm) hypothetical protein 0.0157 0.0818 0.089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0105 0.0365 0.0397
Onchocerca volvulus 0.0351 0.2486 0.3334
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0534 0.0581
Schistosoma mansoni protein kinase 0.0092 0.0254 0.034
Echinococcus multilocularis aurora kinase A 0.0172 0.0941 0.1144
Echinococcus multilocularis serine:threonine protein kinase N2 0.0367 0.2625 0.3193
Echinococcus granulosus casein kinase I alpha 0.0128 0.0559 0.0559
Brugia malayi hypothetical protein 0.0063 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.0471 0.1788
Schistosoma mansoni hypothetical protein 0.0165 0.0879 0.1179
Loa Loa (eye worm) TK/ALK protein kinase 0.0339 0.2388 0.2598
Loa Loa (eye worm) CAMK protein kinase 0.0078 0.0131 0.0143
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0073 0.0085 0.0092
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.014 0.0665 0.0723
Echinococcus granulosus twitchin 0.0145 0.0712 0.0712
Schistosoma mansoni ephrin receptor 0.0132 0.0601 0.0806
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Loa Loa (eye worm) TK/FAK protein kinase 0.0671 0.5243 0.5705
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0085 0.019 0.023
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.01 0.0324 0.0185
Loa Loa (eye worm) TK/FER protein kinase 0.0118 0.0479 0.0521
Brugia malayi Protein kinase domain 0.01 0.0325 0.0354
Echinococcus granulosus protein kinase c epsilon type 0.0263 0.1729 0.1728
Echinococcus multilocularis acetylcholinesterase 0.0077 0.012 0.0145
Brugia malayi protein kinase C II. 0.0263 0.1729 0.1881
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Echinococcus granulosus NCK adaptor protein 0.0103 0.035 0.0349
Brugia malayi Protein kinase domain containing protein 0.1128 0.919 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0149 0.0741 0.09
Echinococcus multilocularis Mastin 0.0216 0.1324 0.161
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0665 0.2522
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.036 0.0483
Loa Loa (eye worm) hypothetical protein 0.0105 0.0365 0.0397
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0134 0.0617 0.075
Echinococcus granulosus serine threonine protein kinase nrc 0.0185 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.025 0.1616 0.1758
Brugia malayi Protein kinase domain containing protein 0.0343 0.2421 0.2635
Echinococcus multilocularis casein kinase I alpha 0.0128 0.0559 0.068
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0238 0.1513 0.184
Schistosoma mansoni serine/threonine protein kinase 0.0387 0.2802 0.3758
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0312 0.2153 0.2343
Echinococcus multilocularis dual specificity 0.01 0.0324 0.0394
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0263 0.1729 0.1881
Brugia malayi Protein kinase domain containing protein 0.023 0.1441 0.1568
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0099 0.0311 0.0913
Trypanosoma cruzi casein kinase, putative 0.0128 0.0559 0.0751
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.1025 0.1376
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0264 0.1739 0.2115
Schistosoma mansoni serine/threonine protein kinase 0.0367 0.2625 0.3522
Trypanosoma brucei casein kinase I, isoform 2 0.0128 0.0559 0.1511
Echinococcus granulosus protein kinase c iota type 0.0361 0.2574 0.2574
Giardia lamblia Kinase, NEK 0.0161 0.0844 0.7551
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0591 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0927 0.7454 0.8111
Brugia malayi Protein kinase domain containing protein 0.0368 0.2634 0.2867
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.0471 0.1788
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0098 0.0301 0.0404
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.036 0.1366
Schistosoma mansoni suppressor of cytokine signaling 0.0063 0.0001 0.0001
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0185 0.1056 0.1307
Loa Loa (eye worm) hypothetical protein 0.0118 0.0478 0.0521
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0152 0.0767 0.1029
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1441 0.1752
Onchocerca volvulus 0.0157 0.0818 0.1096
Trichomonas vaginalis AGC family protein kinase 0.0211 0.1282 0.4867
Plasmodium falciparum calcium-dependent protein kinase 1 0.0118 0.0478 0.0397
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0224 0.139 0.139
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.01 0.0325 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.1282 0.172
Echinococcus granulosus MAP kinase activated protein kinase 2 0.047 0.3517 0.3516
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.1324 0.1776
Schistosoma mansoni growth factor receptor-bound protein 0.0106 0.037 0.0497
Trichomonas vaginalis AGC family protein kinase 0.0236 0.1494 0.5671
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0278 0.1055
Toxoplasma gondii casein kinase I 0.0128 0.0559 0.0509
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0479 0.3591 0.3591
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0086 0.0203 0.0272
Onchocerca volvulus Tyrosine kinase homolog 0.0453 0.3366 0.4515
Loa Loa (eye worm) hypothetical protein 0.0134 0.0616 0.067
Loa Loa (eye worm) TK/INSR protein kinase 0.0539 0.4106 0.4468
Schistosoma mansoni tyrosine kinase 0.0375 0.269 0.3609
Echinococcus granulosus acetylcholinesterase 0.0077 0.012 0.0119
Loa Loa (eye worm) hypothetical protein 0.0086 0.0203 0.022
Echinococcus granulosus casein kinase I delta 0.0128 0.0559 0.0559
Echinococcus granulosus c src tyrosine kinase 0.0159 0.0828 0.0828
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0479 0.3591 0.4368
Schistosoma mansoni protein kinase 0.0074 0.01 0.0134
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0144 0.07 0.0939
Echinococcus multilocularis serine:threonine protein kinase N2 0.0211 0.1282 0.1559
Brugia malayi Trypsin family protein 0.0216 0.1324 0.1441
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0437 0.3233 0.3518
Schistosoma mansoni tyrosine kinase 0.0663 0.518 0.695
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0665 0.0891
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0182 0.1025 0.1376
Onchocerca volvulus 0.0157 0.0818 0.1096
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.014 0.0665 0.0653
Echinococcus granulosus aurora kinase A 0.0172 0.0941 0.094
Plasmodium falciparum glycogen synthase kinase 3 0.0152 0.0767 0.0794
Brugia malayi putative serine/threonine kinase SADA gamma 0.0104 0.036 0.0392
Mycobacterium ulcerans hypothetical protein 0.0216 0.1324 0.3832
Trichomonas vaginalis CAMK family protein kinase 0.0135 0.0626 0.2376
Onchocerca volvulus 0.0118 0.0479 0.0642
Onchocerca volvulus 0.0216 0.1324 0.1775
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0256 0.1671 0.2032
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0058 0.0222
Echinococcus granulosus protein kinase C gamma type 0.026 0.1706 0.1706
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.014 0.0665 0.0723
Leishmania major protein kinase, putative 0.0182 0.1025 0.115
Brugia malayi Kringle domain containing protein 0.0927 0.7454 0.8111
Schistosoma mansoni tyrosine kinase 0.0312 0.2149 0.2884
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0144 0.07 0.0702
Echinococcus multilocularis dual specificity 0.01 0.0324 0.0394
Brugia malayi SH2 domain containing protein 0.0063 0.0001 0.0001
Brugia malayi Stress-activated protein kinase jnk-1 0.0314 0.2171 0.2362
Onchocerca volvulus 0.0157 0.0818 0.1096
Plasmodium falciparum cGMP-dependent protein kinase 0.0159 0.0828 0.0878
Entamoeba histolytica protein kinase, putative 0.01 0.0324 0.0953
Trichomonas vaginalis hypothetical protein 0.0368 0.2631 0.9986
Brugia malayi Trypsin family protein 0.0216 0.1324 0.1441
Brugia malayi Carboxylesterase family protein 0.0077 0.012 0.0131
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0256 0.1671 0.1671
Trypanosoma cruzi casein kinase II, putative 0.0117 0.0471 0.0632
Loa Loa (eye worm) hypothetical protein 0.0063 0.0001 0.0001
Giardia lamblia Kinase, NEK 0.0161 0.0844 0.7551
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.036 0.0483
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0534 0.0716
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0558 0.4269 0.4268
Toxoplasma gondii microneme protein, putative 0.0157 0.0818 0.0864
Schistosoma mansoni growth factor receptor-bound protein 0.0103 0.035 0.0469
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0311 0.2139 0.2602
Echinococcus multilocularis Immunoglobulin 0.0086 0.0203 0.0246
Schistosoma mansoni adapter molecule crk 0.0103 0.035 0.0469
Loa Loa (eye worm) hypothetical protein 0.0157 0.0818 0.089
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0172 0.0941 0.1144
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0238 0.1513 0.1647
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.036 0.0483
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0193 0.1127 0.1513
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0272 0.0365
Brugia malayi Trypsin-like protease protein 5 0.0216 0.1324 0.1441
Brugia malayi PAN domain containing protein 0.0157 0.0818 0.089
Echinococcus multilocularis neuroglian 0.0109 0.0396 0.0481
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0256 0.1671 0.1671
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0097 0.0295 0.0428
Entamoeba histolytica PH domain containing protein kinase, putative 0.0193 0.1127 0.3319
Echinococcus granulosus fibroblast growth factor receptor 4 0.0294 0.1992 0.1991

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.054 uM Inhibition of PKCtheta by FP assay ChEMBL. 17055721
IC50 (binding) = 0.054 uM Inhibition of PKCtheta by FP assay ChEMBL. 17055721
IC50 (functional) = 0.19 uM Inhibition of IL2 production in anti-CD3/anti-CD8 mAbs-stimulated human CD4+ T cells ChEMBL. 17055721
IC50 (ADMET) = 1.7 uM Inhibition of CYP2D6 ChEMBL. 17055721
IC50 (ADMET) = 1.7 uM Inhibition of CYP3A4 in presence of BFC substrate ChEMBL. 17055721
IC50 (ADMET) = 1.7 uM Inhibition of CYP2D6 ChEMBL. 17055721
IC50 (ADMET) = 1.7 uM Inhibition of CYP3A4 in presence of BFC substrate ChEMBL. 17055721
IC50 (ADMET) = 8.4 uM Inhibition of CYP2C9 ChEMBL. 17055721
IC50 (ADMET) = 8.4 uM Inhibition of CYP2C9 ChEMBL. 17055721
IC50 (ADMET) = 13 uM Inhibition of CYP3A4 in presence of BQ substrate ChEMBL. 17055721
IC50 (ADMET) = 13 uM Inhibition of CYP3A4 in presence of BQ substrate ChEMBL. 17055721
permeability (ADMET) = 10.2 10^-6 cm/s Permeability across Caco2 cells from basolateral to apical side ChEMBL. 17055721
permeability (ADMET) = 10.2 10^-6 cm/s Permeability across Caco2 cells from basolateral to apical side ChEMBL. 17055721
permeability (ADMET) = 10.6 10^-6 cm/s Permeability across Caco2 cells from apical to basolateral side ChEMBL. 17055721
permeability (ADMET) = 10.6 10^-6 cm/s Permeability across Caco2 cells from apical to basolateral side ChEMBL. 17055721
t1/2 (ADMET) = 40 min Stability in human liver microsomes ChEMBL. 17055721

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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