Detailed information for compound 503814

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 625.719 | Formula: C37H35N7O3
  • H donors: 3 H acceptors: 4 LogP: 4.87 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(c(c1)OC)Cn1c(CCc2c[nH]c3c2cccc3)nnc1[C@@H](c1c[nH]c2c1cccc2)NC(=O)Cc1ccccn1
  • InChi: 1S/C37H35N7O3/c1-46-27-16-14-25(33(20-27)47-2)23-44-34(17-15-24-21-39-31-12-5-3-10-28(24)31)42-43-37(44)36(30-22-40-32-13-6-4-11-29(30)32)41-35(45)19-26-9-7-8-18-38-26/h3-14,16,18,20-22,36,39-40H,15,17,19,23H2,1-2H3,(H,41,45)/t36-/m1/s1
  • InChiKey: GPBBQJBXTDZSOZ-PSXMRANNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens growth hormone secretagogue receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni rhodopsin-like orphan GPCR growth hormone secretagogue receptor 289 aa 243 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0018 0.015
Loa Loa (eye worm) hypothetical protein 0.0259 0.0846 0.188
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.047 0.157 0.6173
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0336 0.0637
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1543 0.5246 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0018 0.0061
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0217 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0044
Echinococcus multilocularis cpg binding protein 0.0065 0.0183 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Trichomonas vaginalis helicase, putative 0.0014 0.0007 0.0009
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0312 0.1028 1
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0217 0.0479
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0423 0.1408 0.5537
Echinococcus granulosus transcription factor Dp 1 0.0079 0.023 0.0228
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0234 0.076 0.7381
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.014 0.0138
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0036 0.0034
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0013 0.0108
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0179 0.1726
Mycobacterium ulcerans NADH dehydrogenase 0.0017 0.0018 0.0061
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0063 0.0175 0.8264
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0084
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0018 0.0029
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0077 0.0922
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0046 0.0083
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0078 0.0739
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0077 0.0731
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0048 0.0101
Echinococcus granulosus 6 phosphofructokinase 0.0234 0.076 0.0758
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0116 0.0254
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.0179 0.1726
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0083 0.0081
Trichomonas vaginalis rotamase, putative 0.0036 0.0081 0.015
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.014 0.0138
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0018 0.026
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0078 0.0145
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0025 0.0023
Schistosoma mansoni transcription factor btf3 0.011 0.0336 0.0334
Mycobacterium ulcerans 6-phosphofructokinase 0.0234 0.076 0.2982
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0154 0.0338
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0006 0.0004
Trichomonas vaginalis rotamase, putative 0.0035 0.0078 0.0145
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0179 0.1726
Echinococcus granulosus bloom syndrome protein 0.0046 0.0116 0.0114
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0018 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1543 0.5246 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0816 0.3203
Echinococcus multilocularis glutamate synthase 0.0017 0.0018 0.0016
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0039 0.0361
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0063 0.0751
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0017 0.0018 0.0061
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0445 0.0443
Echinococcus multilocularis pyruvate kinase 0.0034 0.0077 0.0075
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0024 0.0212
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.003 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.003 0.0028
Echinococcus granulosus mitogen activated protein kinase 0.0115 0.0353 0.0351
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0073 0.0209 0.0812
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0053 0.0051
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0017 0.0018 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0136 0.1306
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.0106
Brugia malayi 6-phosphofructokinase 0.0234 0.076 0.1687
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0104 0.0314 0.0595
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0043 0.0399
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0084
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0179 0.1726
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1543 0.5246 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0063 0.0175 0.8264
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0014 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0051
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0014 0.0006 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0013 0.0025
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0023
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0024 0.0034
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.003 0.0062
Trypanosoma cruzi transcription factor btf3, putative 0.011 0.0336 0.3254
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0115 0.0353 0.4312
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0014 0.0006 0.0016
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.025 0.0816 0.793
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0209 0.0812
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0077 0.0167
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0018 0.0029
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0046 0.0043
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0077 0.0731
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0023
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0024 0.0042
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0018 0.0034
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0259 0.0846 0.0844
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0122 0.0378 0.0376
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0055 0.0887
Onchocerca volvulus 0.0046 0.0118 0.0227
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0024 0.0022
Brugia malayi Thioredoxin reductase 0.0185 0.0595 0.132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0191 0.0613 0.0611
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0025 0.0051
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0023
Mycobacterium ulcerans hypothetical protein 0.0164 0.0522 0.2047
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0077 0.0147
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0013 0.0025
Plasmodium falciparum thioredoxin reductase 0.0064 0.0179 0.299
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0018 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0353 0.0669
Loa Loa (eye worm) glutaminase 2 0.0275 0.0902 0.2004
Loa Loa (eye worm) glutaminase 0.0275 0.0902 0.2004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0024 0.0042
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0174 0.0172
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0034
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0004
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0024 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.003 0.0028
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0187 0.0598 0.2347
Entamoeba histolytica phosphofructokinase, putative 0.0234 0.076 0.1444
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0018 0.015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0179 0.1726
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0295 0.0557
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0023
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0295 0.0292
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0036 0.0034
Brugia malayi mbt repeat family protein 0.0046 0.0118 0.0259
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0353 0.0669
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0175 0.033
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0754 0.2542 1
Brugia malayi MAP kinase sur-1 0.0115 0.0353 0.0782
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0018 0.0029
Chlamydia trachomatis pyruvate kinase 0.0034 0.0077 0.3123
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0078 0.0739
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0465 0.4512
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.025 0.0816 0.3203
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0295 0.0292
Echinococcus granulosus pyruvate kinase 0.0018 0.002 0.0018
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0077 0.0295
Loa Loa (eye worm) hypothetical protein 0.0102 0.0308 0.0682
Schistosoma mansoni pyruvate kinase 0.0034 0.0077 0.0075
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0078 0.0932
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0013 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0004
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0006 0.0008
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0018 0.0016
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0018 0.015
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0039 0.0037
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.014 0.0138
Brugia malayi Cytochrome P450 family protein 0.003 0.0063 0.0136
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0011 0.0008
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0115 0.0353 0.0782
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0084
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0017 0.0018 0.0061
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0171 0.0375
Brugia malayi CXXC zinc finger family protein 0.0062 0.0171 0.0375
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0064 0.0761
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.2664 0.2662
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0017 0.0018 0.0029
Schistosoma mansoni rotamase 0.0036 0.0081 0.0079
Brugia malayi polk-prov protein 0.0052 0.0136 0.0298
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.0353 0.3419
Echinococcus multilocularis mitogen activated protein kinase 0.0115 0.0353 0.0351
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0064 0.0179 0.0395
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0051
Leishmania major DNA polymerase kappa, putative 0.0023 0.0039 0.0361
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0014 0.0006 0.004
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0006 0.004
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0014 0.0006 0.004
Echinococcus granulosus lamin 0.0057 0.0154 0.0152
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0268
Schistosoma mansoni ap endonuclease 0.0019 0.0024 0.0022
Schistosoma mansoni intermediate filament proteins 0.0057 0.0154 0.0152
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0046 0.0533
Echinococcus multilocularis pyruvate kinase 0.0034 0.0077 0.0075
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.011 0.1046
Loa Loa (eye worm) ICD-1 protein 0.011 0.0336 0.0744
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0115 0.0353 0.3419
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0202 0.0652 0.065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0048
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0018 0.0061
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0016
Leishmania major pyruvate kinase 0.0034 0.0077 0.0731
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.0522 0.2047
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0024 0.0022
Entamoeba histolytica hypothetical protein 0.0019 0.0025 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0295 0.0557
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0295 0.0557
Leishmania major basic transcription factor 3a, putative 0.011 0.0336 0.3254
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0039 0.0361
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0018 0.0016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0062 0.0235
Plasmodium falciparum glutathione reductase 0.0185 0.0595 1
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0269 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0191 0.0613 0.0611
Brugia malayi CHD4 protein 0.0015 0.0011 0.0019
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.014 0.0138
Mycobacterium ulcerans glutamate synthase subunit beta 0.0017 0.0018 0.0061
Brugia malayi PXA domain containing protein 0.0019 0.0025 0.0051
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0046 0.0083
Giardia lamblia DNA damage repair protein 0.0023 0.0039 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0137 0.0427 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0039 0.0361
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0014 0.0006 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.1028 1
Plasmodium vivax thioredoxin reductase, putative 0.0185 0.0595 0.9698
Brugia malayi intermediate filament protein 0.0057 0.0154 0.0338
Entamoeba histolytica hypothetical protein 0.011 0.0336 0.0637
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0011 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0049 0.0046
Toxoplasma gondii thioredoxin reductase 0.0185 0.0595 0.7281
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0014 0.0006 0.0016
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0014 0.0006 0.0004
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0174 0.0555 0.1233
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0073 0.0209 0.2536
Echinococcus granulosus pyruvate kinase 0.0034 0.0077 0.0075
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0006 0.004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0064 0.0179 0.0697
Echinococcus multilocularis 6 phosphofructokinase 0.0234 0.076 0.0758
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0084
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0024 0.0049
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.1369 0.1367
Schistosoma mansoni glutamate synthase 0.0017 0.0018 0.0016
Echinococcus granulosus pyruvate kinase 0.0018 0.002 0.0018
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0025 0.0023
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0018 0.0189
Leishmania major DNA polymerase kappa, putative 0.0082 0.0241 0.2329
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0106 0.1277
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0336 0.0637
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0179 0.8585
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0024 0.0086
Brugia malayi hypothetical protein 0.0019 0.0025 0.0051
Plasmodium vivax JmjC domain containing protein 0.0016 0.0013 0.0217
Echinococcus multilocularis dna polymerase eta 0.0075 0.0217 0.0215
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0191 0.0613 0.1361
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0018 0.0029
Treponema pallidum thioredoxin reductase (trxB) 0.0017 0.0018 0.0022
Brugia malayi Cytochrome P450 family protein 0.003 0.0062 0.0133
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0039 0.0625
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0077 0.0147
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0063 0.0175 0.033
Leishmania major DNA damage repair protein, putative 0.0023 0.0039 0.0361
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0064 0.0179 0.2177
Schistosoma mansoni DNA helicase recq1 0.0019 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0009
Echinococcus multilocularis transcription factor btf3 0.011 0.0336 0.0334
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0047 0.0121 0.0264
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0014 0.0006 0.004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0064 0.0179 0.847
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0014 0.0006 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0295 0.0557
Entamoeba histolytica transcription factor BTF3, putative 0.011 0.0336 0.0637
Loa Loa (eye worm) MBCTL1 0.0053 0.014 0.0308
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0187 0.0598 0.1329
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.0241 0.0941
Giardia lamblia Kinase, CMGC MAPK 0.0115 0.0353 0.0669
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0179 0.1726
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0046 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0179 0.1726
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0042 0.0088
Schistosoma mansoni hypothetical protein 0.0025 0.0045 0.0042
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.047 0.157 0.6173
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0014 0.0006 0.0004
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0116 0.0218
Echinococcus multilocularis pyruvate kinase 0.0018 0.002 0.0018
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0122 0.0378 0.0376
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0018 0.0061
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.0378 0.0836
Echinococcus granulosus pyruvate kinase 0.0034 0.0077 0.0075
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0025 0.0051
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0137 0.0427 0.0947
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0043 0.0399
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0116 0.0114
Entamoeba histolytica hypothetical protein 0.0073 0.0209 0.0393
Leishmania major DNA polymerase eta, putative 0.0023 0.0039 0.0361
Brugia malayi hypothetical protein 0.0122 0.0379 0.0839
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.003 0.0062
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0025 0.0023
Echinococcus granulosus geminin 0.0543 0.1819 0.1817
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0018 0.0029
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0018 0.0029
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0017 0.0018 0.0746
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0004
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0234 0.076 0.2982
Plasmodium vivax basic transcription factor 3b, putative 0.011 0.0336 0.5483
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0017 0.0018 0.0061
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0179 0.1726
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0118 0.0116
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.0023
Brugia malayi glutathione reductase 0.0185 0.0595 0.132
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0024 0.0368
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0018 0.0016
Trypanosoma brucei unspecified product 0.0052 0.0137 0.1314
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0014 0.0006 0.0016
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0118 0.0116
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0025 0.0044
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0025 0.0023
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0013 0.0011
Onchocerca volvulus 0.0202 0.0652 0.1271
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0024 0.0042
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0018 0.0029
Echinococcus multilocularis lamin 0.0057 0.0154 0.0152
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0018 0.015
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0063 0.0175 0.033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0044
Leishmania major hypothetical protein, conserved 0.0017 0.0018 0.015
Echinococcus multilocularis musashi 0.0057 0.0154 0.0152
Onchocerca volvulus 0.0057 0.0154 0.0297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0179 0.1726
Trichomonas vaginalis dullard protein, putative 0.0025 0.0046 0.0083
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0295 0.0557
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0013 0.0011
Brugia malayi glutaminase DH11.1 0.0275 0.0902 0.2004
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0081 0.015
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0064 0.0179 0.1726
Onchocerca volvulus 0.0057 0.0154 0.0297
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0142 0.1366
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0024 0.0049
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0018 0.0289
Loa Loa (eye worm) hypothetical protein 0.0102 0.0308 0.0682
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0073 0.0209 0.0812
Leishmania major phosphopantetheinyl transferase-like protein 0.0073 0.0209 0.2011
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0234 0.076 0.7381
Echinococcus granulosus cpg binding protein 0.0065 0.0183 0.0181
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0077 0.0167
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0018 0.0034
Plasmodium vivax glutathione reductase, putative 0.0185 0.0595 0.9698
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0187 0.0598 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0423 0.1408 0.5537
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0046 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0191 0.0613 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0044
Schistosoma mansoni 6-phosphofructokinase 0.0234 0.076 0.0758
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0051
Schistosoma mansoni glutaminase 0.0275 0.0902 0.09
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0423 0.1408 0.5537
Echinococcus multilocularis lamin dm0 0.0057 0.0154 0.0152
Trypanosoma brucei trypanothione reductase 0.0185 0.0595 0.5773
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0018 0.015
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0025 0.0051
Leishmania major pyruvate kinase 0.0034 0.0077 0.0731
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0217 0.0215
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0353 0.0669
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0081 0.0175
Trypanosoma cruzi transcription factor btf3, putative 0.011 0.0336 0.3254
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0295 0.2849
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0064 0.0179 0.0697
Toxoplasma gondii histone lysine methyltransferase SET1 0.0127 0.0396 0.4839
Mycobacterium ulcerans dehydrogenase 0.0017 0.0018 0.0061
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0118 0.0116
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.014 0.0308
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0077 0.0731
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0295 0.0557
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.011 0.1046
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0064 0.0179 0.299
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0118 0.0116
Mycobacterium ulcerans hypothetical protein 0.0023 0.0039 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Schistosoma mansoni kinase 0.005 0.0131 0.0129
Loa Loa (eye worm) POT family protein 0.009 0.0268 0.0591
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0043 0.0399
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0018 0.0016
Schistosoma mansoni ap endonuclease 0.0019 0.0024 0.0022
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0014 0.0006 0.0016
Plasmodium vivax 6-phosphofructokinase, putative 0.0063 0.0175 0.2862
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0006 0.004
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0006 0.004
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0073 0.0209 1
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0013 0.0011
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0018 0.0289
Mycobacterium ulcerans monoxygenase 0.0017 0.0018 0.0061
Brugia malayi Cytochrome P450 family protein 0.003 0.0062 0.0133
Brugia malayi jmjC domain containing protein 0.0016 0.0013 0.0025
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0014 0.0006 0.0004
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0106 0.1277
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.0816 0.0814
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.011 0.1046
Echinococcus multilocularis 0.0025 0.0046 0.0043
Brugia malayi hypothetical protein 0.0155 0.049 0.1087
Loa Loa (eye worm) hypothetical protein 0.0075 0.0217 0.0479
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0295 0.0651
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0017 0.0018 0.0746
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0024 0.0393
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0018 0.015
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0018 0.015
Echinococcus multilocularis geminin 0.0543 0.1819 0.1817
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0014 0.0006 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0295 0.0557
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0017 0.0018 0.0061
Loa Loa (eye worm) hypothetical protein 0.0034 0.0077 0.0167
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0137 0.0427 0.4144
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0025 0.0051
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0014 0.0006 0.0199
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0025 0.0023
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0013 0.0011
Brugia malayi 6-phosphofructokinase 0.0234 0.076 0.1687
Schistosoma mansoni glutamate synthase 0.0017 0.0018 0.0016
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0039 0.0361
Loa Loa (eye worm) acetyltransferase 0.0146 0.0459 0.1018
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.011 0.1046
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0018 0.0016
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0014 0.0006 0.0004
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0025 0.0051
Echinococcus multilocularis transcription factor Dp 1 0.0079 0.023 0.0228
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0014 0.0006 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0816 0.3203
Toxoplasma gondii 6-phosphofructokinase 0.0063 0.0175 0.2129
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0025 0.0051
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0024 0.0086
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.0269 0.0267
Loa Loa (eye worm) aldehyde dehydrogenase 0.0014 0.0006 0.0009
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0014 0.0006 0.005
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0154 0.0338
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0024 0.0212
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0183
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0014 0.0006 0.0016
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0053 0.0051
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0465 0.4512
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0064 0.0179 0.0177
Echinococcus multilocularis expressed protein 0.0376 0.1246 0.1244
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0094 0.0175
Mycobacterium ulcerans glutaminase 0.0275 0.0902 0.3541
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0014 0.0006 0.0009
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0137 0.0427 0.0425
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0018 0.0016
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.0241 0.2329
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.0108
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0106 0.0104
Echinococcus granulosus pyruvate kinase 0.0018 0.002 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0024 0.0042
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0137 0.0427 0.0947
Leishmania major DNA polymerase eta, putative 0.0075 0.0217 0.2095
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0017 0.0018 0.0029
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0014 0.0006 0.0016
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0046 0.0097
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0073 0.0209 0.3403
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0063 0.0175 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0161 0.1549
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0025 0.0023
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0014 0.0006 0.0009
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0018 0.0034
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0046 0.0043
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0064 0.0137
Brugia malayi mbt repeat family protein 0.0046 0.0118 0.0259
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0308
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0013 0.0186
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0049 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1543 0.5246 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0024 0.0212
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0039 0.0641
Loa Loa (eye worm) glutathione reductase 0.0185 0.0595 0.132
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0064 0.0179 0.0697
Brugia malayi jmjC domain containing protein 0.0063 0.0174 0.0383
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0118 0.0116
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0018 0.0029
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0018 0.0189
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0063 0.0175 0.2924
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0423 0.1408 0.5537
Toxoplasma gondii selenide, water dikinase 0.0017 0.0018 0.0189
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0036 0.0034
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0024 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0064 0.0179 0.2926
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0046 0.0422
Trypanosoma brucei unspecified product 0.0097 0.029 0.2805
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0064 0.0179 0.299
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0018 0.026
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0137 0.0427 0.4144
Echinococcus multilocularis mitogen activated protein kinase 3 0.0115 0.0353 0.0351
Loa Loa (eye worm) hypothetical protein 0.0057 0.0154 0.0338
Giardia lamblia NADH oxidase lateral transfer candidate 0.0064 0.0179 0.0338
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0025 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0191 0.0613 0.0611
Plasmodium falciparum basic transcription factor 3b, putative 0.011 0.0336 0.5636
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.003 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0063 0.0136
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0013 0.0011
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0046 0.0083
Brugia malayi glutamate synthase 0.0017 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0155 0.049 0.1087
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0018 0.0034
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0039 0.0455
Echinococcus granulosus expressed protein 0.0036 0.0081 0.0079
Echinococcus granulosus transcription factor btf3 0.011 0.0336 0.0334
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0024 0.0049
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0295 0.2849
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0039 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Echinococcus granulosus Solute carrier family 22 5 0.1142 0.3872 0.3871
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0161 0.1549
Entamoeba histolytica hypothetical protein 0.0019 0.0025 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0217 0.0479
Echinococcus granulosus dna polymerase eta 0.0075 0.0217 0.0215
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0064 0.0179 0.1726
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0018 0.0034
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0063 0.0175 0.0323
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0025 0.0023
Echinococcus granulosus lamin dm0 0.0057 0.0154 0.0152
Entamoeba histolytica thioredoxin reductase, putative 0.0017 0.0018 0.0029
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0014 0.0006 0.004
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0046 0.0043
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0162 0.016
Schistosoma mansoni hypothetical protein 0.0014 0.0006 0.0004
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0018 0.0029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0217 0.0215
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0013 0.0011
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0055 0.0646
Echinococcus multilocularis pyruvate kinase 0.0027 0.0052 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.0314 0.3039
Trypanosoma brucei transcription factor BTF3, putative 0.011 0.0336 0.3254
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0042 0.0075
Brugia malayi jmjC domain containing protein 0.0016 0.0013 0.0025
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0046 0.0083
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0011 0.0008
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0043 0.0078
Leishmania major hypothetical protein, conserved 0.0028 0.0055 0.0512
Schistosoma mansoni DNA helicase recq5 0.0019 0.0024 0.0022
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0006 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0046 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0021 0.0035
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0064 0.0137
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0017 0.0018 0.0061
Schistosoma mansoni lamin 0.0057 0.0154 0.0152
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0816 0.3203
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0039 0.0361
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0018 0.0061
Brugia malayi Aldehyde dehydrogenase protein 4 0.0014 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0117
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0014 0.0006 0.0016
Schistosoma mansoni glutamate synthase 0.0017 0.0018 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0039 0.0361
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0268
Onchocerca volvulus 0.0062 0.0171 0.0329
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0006 0.0004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0049
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0006 0.0008
Schistosoma mansoni lamin 0.0057 0.0154 0.0152
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0064 0.0179 0.1726
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0014 0.0006 0.0004
Leishmania major hypothetical protein, conserved 0.0025 0.0046 0.0422
Echinococcus granulosus expressed protein 0.0376 0.1246 0.1244
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.047 0.157 0.6173
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0127 0.0238
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0077 0.0167
Echinococcus multilocularis dna polymerase kappa 0.0104 0.0314 0.0312
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0049
Plasmodium falciparum pyruvate kinase 0.0034 0.0077 0.1267
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0185 0.0595 0.2332
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0014 0.0006 0.0004
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0187 0.0598 0.5811
Trichomonas vaginalis phosphofructokinase, putative 0.0234 0.076 0.1444
Trichomonas vaginalis phosphofructokinase, putative 0.0234 0.076 0.1444
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0017 0.0018 0.0061
Giardia lamblia Fructose-bisphosphate aldolase 0.1543 0.5246 1
Onchocerca volvulus 0.0102 0.0308 0.0599
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0063 0.0175 0.2924
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0115 0.0353 0.3419
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0055 0.0895
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0073 0.0209 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0127 0.0238
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0014 0.0006 0.0016
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0023
Schistosoma mansoni hypothetical protein 0.0052 0.0138 0.0135
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0014 0.0006 0.0016
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0017 0.0018 0.0061
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0018 0.0029
Echinococcus multilocularis microtubule associated protein 2 0.2931 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0175 0.033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0024 0.0368
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.1028 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0047 0.0121 0.0264
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0077 0.0143
Brugia malayi hypothetical protein 0.0019 0.0025 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.0816 0.0814
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0014 0.0006 0.0016
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0217 0.0479
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0295 0.0651
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0174 0.0172
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0179 0.1726
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.002 0.0216
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0064 0.0179 0.0177
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0073 0.0209 0.0812
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.003 0.0028
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0018 0.0016
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0014 0.0006 0.005
Plasmodium vivax SET domain protein, putative 0.0191 0.0613 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0094
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0014 0.0006 0.0016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0186 0.0596 0.0594
Giardia lamblia Alcohol dehydrogenase 0.0014 0.0006 0.0008
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0014 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0319 0.1053 0.2341
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.029 0.2805
Echinococcus multilocularis pyruvate kinase 0.0018 0.002 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0062 0.0133
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0097 0.1604
Onchocerca volvulus 0.1505 0.5115 1
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0018 0.015
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0077 0.0295
Giardia lamblia DINP protein human, muc B family 0.0082 0.0241 0.0456
Echinococcus granulosus histone lysine methyltransferase setb 0.0191 0.0613 0.0611
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0014 0.0006 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1323 0.449 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0018 0.0016
Treponema pallidum NADH oxidase 0.0064 0.0179 0.033
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0137 0.0427 0.0811
Onchocerca volvulus 0.0017 0.0018 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0295 0.0557
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0023
Echinococcus multilocularis L aminoadipate semialdehyde 0.0259 0.0846 0.0844
Mycobacterium ulcerans ferredoxin reductase 0.0017 0.0018 0.0061
Plasmodium vivax steroid dehydrogenase, putative 0.0013 0.0002 0.0037
Schistosoma mansoni hypothetical protein 0.0412 0.1369 0.1367
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.025 0.0816 0.0814
Treponema pallidum oxidoreductase 0.0017 0.0018 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0055 0.0512
Echinococcus granulosus mitogen activated protein kinase 3 0.0115 0.0353 0.0351
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0014 0.0006 0.004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0187 0.0598 0.2347
Trypanosoma brucei polo-like protein kinase 0.0098 0.0295 0.2849
Brugia malayi jmjC domain containing protein 0.0016 0.0013 0.0025
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.0378 0.0376
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0081 0.0175
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0014 0.0006 0.0016
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0063 0.0175 0.2129
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0183 0.0585 0.0583
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0162 0.016
Brugia malayi Pre-SET motif family protein 0.0191 0.0613 0.1361
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0423 0.1408 0.5537
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0179 0.1726
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0046 0.0084
Trypanosoma cruzi trypanothione reductase, putative 0.0185 0.0595 0.5773
Schistosoma mansoni pyruvate kinase 0.0034 0.0077 0.0075
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0073 0.0209 0.2536
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0115 0.0353 0.3419
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0018 0.0016
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0073 0.0209 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0423 0.1408 0.5537
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0295 0.0292
Trichomonas vaginalis DNA polymerase eta, putative 0.0104 0.0314 0.0595
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0046 0.0043
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0013 0.0108
Brugia malayi phosphofructokinase 0.0234 0.076 0.1687
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0122 0.0378 0.0376
Echinococcus granulosus phd:f box containing protein 0.0016 0.0013 0.0011
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0094 0.1548
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1543 0.5246 1
Brugia malayi Pre-SET motif family protein 0.1323 0.449 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0013 0.0011
Entamoeba histolytica phosphofructokinase, putative 0.0234 0.076 0.1444
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0023
Leishmania major ATP-dependent phosphofructokinase 0.0234 0.076 0.7381
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0014 0.0006 0.0016
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0162 0.016
Leishmania major hypothetical protein, conserved 0.0017 0.0018 0.015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Brugia malayi jmjC domain containing protein 0.0059 0.0162 0.0356
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0459 0.1018
Toxoplasma gondii NADPH-glutathione reductase 0.0064 0.0179 0.2177
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0014 0.0006 0.0009
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0018 0.0029
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0599 0.0597
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0018 0.0189
Schistosoma mansoni DNA polymerase eta 0.0075 0.0217 0.0215
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0014 0.0006 0.0008
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0014 0.0006 0.0016
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0295 0.2849
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0077 0.0143
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0599 0.2011 0.383
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0039 0.0455
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0013 0.0136
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0174 0.0172
Leishmania major mitochondrial DNA polymerase beta 0.0312 0.1028 1
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0006 0.0004
Brugia malayi SET domain containing protein 0.002 0.0027 0.0055
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0046 0.0744
Trichomonas vaginalis dullard protein, putative 0.0025 0.0046 0.0083
Schistosoma mansoni microtubule-associated protein tau 0.2931 1 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0018 0.026
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0154 0.0338
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0353 0.0351
Trypanosoma brucei unspecified product 0.0052 0.0137 0.1314
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0025 0.0051
Leishmania major hypothetical protein, conserved 0.0017 0.0018 0.015
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0077 0.0295
Schistosoma mansoni 6-phosphofructokinase 0.0234 0.076 0.0758
Plasmodium falciparum glutathione reductase 0.0064 0.0179 0.299
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0018 0.0029
Schistosoma mansoni hypothetical protein 0.0543 0.1819 0.1817
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0051
Trypanosoma brucei cytochrome P450, putative 0.003 0.0062 0.0582
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0017 0.0018 0.0061
Echinococcus granulosus dna polymerase kappa 0.0104 0.0314 0.0312
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0018 0.015
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Treponema pallidum fructose-bisphosphate aldolase 0.1543 0.5246 1
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0046 0.0422
Giardia lamblia Pyruvate kinase 0.0018 0.002 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0241 0.2329
Giardia lamblia Kinase, PLK 0.0098 0.0295 0.0557
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0006 0.004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0217 0.0846
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.002 0.0324
Toxoplasma gondii NAC domain-containing protein 0.011 0.0336 0.4104
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0077 0.0731
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0025 0.0023
Loa Loa (eye worm) thioredoxin reductase 0.0185 0.0595 0.132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0025
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0017 0.0018 0.0029
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0094 0.0175
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0046 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1543 0.5246 1
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0014 0.0006 0.004
Onchocerca volvulus 0.0155 0.049 0.0954
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0025 0.0023
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0018 0.0016
Leishmania major cytochrome p450-like protein 0.003 0.0062 0.0582
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0014 0.0006 0.0004
Trichomonas vaginalis dullard protein, putative 0.0025 0.0046 0.0083
Brugia malayi hypothetical protein 0.0018 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0025
Entamoeba histolytica disulphide oxidoreductase, putative 0.0017 0.0018 0.0029
Brugia malayi hypothetical protein 0.0028 0.0055 0.0117
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0018 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0025 0.0023
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0078 0.0739
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0062 0.0582
Brugia malayi POT family protein 0.009 0.0268 0.0591
Brugia malayi jmjC domain containing protein 0.0016 0.0013 0.0025
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0118 0.0259
Trichomonas vaginalis phosphofructokinase, putative 0.0234 0.076 0.1444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1543 0.5246 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0118 0.0116
Schistosoma mansoni cpg binding protein 0.0062 0.0171 0.0169
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0039 0.0361
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0018 0.0189
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.0308 0.0682
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0023
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0017 0.0018 0.0061
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.033
Echinococcus granulosus intermediate filament protein 0.0057 0.0154 0.0152
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0062 0.0133
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.0378 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0055 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0136 0.1306
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0024 0.1057
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0175 0.033
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0017 0.0018 0.0029
Loa Loa (eye worm) CYP4Cod1 0.003 0.0062 0.0133
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0064 0.0179 0.0177
Giardia lamblia Glutamate synthase 0.0017 0.0018 0.0029
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0014 0.0006 0.005
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0137 0.0427 0.0425
Trichomonas vaginalis glutaminase, putative 0.0275 0.0902 0.1715
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0465 0.4512
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0018 0.0029
Echinococcus granulosus L aminoadipate semialdehyde 0.0259 0.0846 0.0844
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0046 0.0097
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0106 0.0198
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.0378 0.0836
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0114
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0014 0.0006 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0353 0.0669
Loa Loa (eye worm) hypothetical protein 0.0046 0.0118 0.0259
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0024 0.0042
Loa Loa (eye worm) phosphofructokinase 0.0234 0.076 0.1687
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0459 0.0457
Schistosoma mansoni cpg binding protein 0.0065 0.0183 0.0181
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0014 0.0006 0.0016
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0187 0.0598 0.0596
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0295 0.0572
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0018 0.015
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0175 0.033
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0336 0.0637
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0064 0.0179 0.1726
Echinococcus granulosus thioredoxin glutathione reductase 0.0186 0.0596 0.0594
Mycobacterium ulcerans hypothetical protein 0.0017 0.0018 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0018 0.015
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0234 0.076 0.1437
Echinococcus granulosus dnaJ subfamily B 0.0412 0.1369 0.1367
Loa Loa (eye worm) 6-phosphofructokinase 0.0234 0.076 0.1687
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0754 0.2542 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0018 0.015
Schistosoma mansoni cpg binding protein 0.0065 0.0183 0.0181
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0011 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0234 0.076 0.1444
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0017 0.0018 0.0061
Entamoeba histolytica phosphofructokinase, putative 0.0234 0.076 0.1444
Plasmodium vivax 6-phosphofructokinase, putative 0.0063 0.0175 0.2862
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0017 0.0018 0.0746
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1543 0.5246 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0179 0.1726
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0217 0.041
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0039 0.0361
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0191 0.0613 0.7508
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0269 0.0267
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0025 0.0023
Plasmodium falciparum pyruvate kinase 2 0.0018 0.002 0.0297
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0234 0.076 0.2982
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0018 0.015
Trypanosoma brucei protein kinase, putative 0.0115 0.0353 0.3419
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0018 0.0189
Plasmodium falciparum thioredoxin reductase 0.0185 0.0595 1
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0014 0.0006 0.0016
Trichomonas vaginalis glutathione reductase, putative 0.0064 0.0179 0.0338
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0023
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0024 0.0022
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0018 0.0016
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0064 0.0179 0.0697
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0187 0.0598 0.0596
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0024 0.0022
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0049 0.0103
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0014 0.0006 0.0016
Onchocerca volvulus 0.0102 0.0308 0.0599
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0023
Brugia malayi hypothetical protein 0.0102 0.0308 0.0682
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0014 0.0006 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0209 0.2011
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0115 0.0353 0.3419
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0084
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0115 0.0353 0.3419
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0017 0.0018 0.0061
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0137 0.0427 0.4144
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0013 0.0136
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0013 0.0108
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.014 0.0138
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0065 0.1068
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.003 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0138 0.0432 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0044
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0055 0.0512
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0014 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.0543 0.1819 0.1817
Toxoplasma gondii aldehyde dehydrogenase 0.025 0.0816 1
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0018 0.0016
Toxoplasma gondii exonuclease III APE 0.0019 0.0024 0.0268
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0217 0.0215
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0023
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0217 0.2095
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0014 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.0106
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0077 0.0167
Leishmania major NADH dehydrogenase, putative 0.0017 0.0018 0.015
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.0314 0.1228
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0062 0.0582
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0023
Trichomonas vaginalis set domain proteins, putative 0.1505 0.5115 0.975
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0025 0.0023
Echinococcus multilocularis pyruvate kinase 0.0018 0.002 0.0018
Echinococcus granulosus glutamate synthase 0.0017 0.0018 0.0016
Loa Loa (eye worm) 6-phosphofructokinase 0.0234 0.076 0.1687
Echinococcus multilocularis expressed protein 0.0036 0.0081 0.0079
Loa Loa (eye worm) hypothetical protein 0.0052 0.0136 0.0298
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0006 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.0314 0.1228
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0137 0.0427 0.4144
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0162 0.016
Brugia malayi beta-NAC-like protein 0.011 0.0336 0.0744
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0077 0.0167
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0179 0.1726
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0018 0.0029
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0459 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0314 0.3039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0036 0.0034
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0024 0.0022
Giardia lamblia Thioredoxin reductase 0.0017 0.0018 0.0029
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0018 0.015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0024 0.0042
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0046 0.0744
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0118 0.0227
Entamoeba histolytica hypothetical protein 0.0019 0.0025 0.0044
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0078 0.0739
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0009
Mycobacterium tuberculosis Probable oxidoreductase 0.047 0.157 0.6173
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0046 0.0731
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.0269 0.0267
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0175 0.033
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0017 0.0018 0.0061
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0018 0.0016
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0018 0.015
Schistosoma mansoni hypothetical protein 0.0286 0.0939 0.0938
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0179 0.8585
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0599 0.0597
Toxoplasma gondii phosphofructokinase PFKII 0.0063 0.0175 0.2129
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0259 0.0846 0.188
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0025 0.0023
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0018 0.015
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0118 0.0116
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0039 0.0361
Schistosoma mansoni pyruvate kinase 0.0018 0.002 0.0018
Giardia lamblia Pyruvate kinase 0.0034 0.0077 0.0143
Brugia malayi PXA domain containing protein 0.0019 0.0025 0.0051
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0116 0.0218
Mycobacterium tuberculosis Probable reductase 0.0423 0.1408 0.5537
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0024 0.0212
Toxoplasma gondii hypothetical protein 0.005 0.0132 0.159
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0013 0.0011
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0014 0.0006 0.0016
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1543 0.5246 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0084
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0018 0.0289
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0077 0.0147
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0002 0.0037
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0013 0.0011
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.0314 0.3039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1543 0.5246 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0106 0.1732
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.0023
Leishmania major trypanothione reductase 0.0185 0.0595 0.5773
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0064 0.0179 0.2926
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0055 0.0887
Loa Loa (eye worm) RecQ helicase 0.0046 0.0116 0.0254
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0018 0.0016
Brugia malayi aldehyde dehydrogenase 0.0014 0.0006 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0013 0.0011
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0043 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0175 0.033
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0036 0.0034
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0014 0.0006 0.0004
Trichomonas vaginalis mercuric reductase, putative 0.0064 0.0179 0.0338
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0014 0.0006 0.0008
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0754 0.2542 1
Trypanosoma brucei DNA polymerase eta, putative 0.0075 0.0217 0.2095
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0187 0.0598 0.2347
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0106 0.0198
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.025 0.0816 0.0814
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.0353 0.3419
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0599 0.2011 0.383
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0049
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0174 0.0383
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0077 0.1261
Onchocerca volvulus 0.0259 0.0846 0.165
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0161 0.1549
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0191 0.0613 0.0611
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0073 0.0209 0.3484

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Agonist activity at GHSR1a (unknown origin) expressed in CHO cells assessed as accumulation of intracellular calcium level at 10 uM relative to ghrelin ChEMBL. 18193826
Activity (functional) = 0 % Agonist activity at GHSR1a (unknown origin) expressed in CHO cells assessed as accumulation of intracellular calcium level at 10 uM relative to ghrelin ChEMBL. 18193826
Activity (functional) = 0.02 g Effect on food intake per 100 gm of body weight in rat at 106 ug/kg, sc after 2 hrs ChEMBL. 18193826
Activity (functional) = 0.02 g Effect on food intake per 100 gm of body weight in rat at 106 ug/kg, sc after 6 hrs ChEMBL. 18193826
Activity (functional) = 0.37 g Inhibition of hexarelin induced food intake per 100 gm of body weight in rat at 106 ug/kg. sc after 2 hrs ChEMBL. 18193826
Activity (functional) = 0.64 g Inhibition of hexarelin induced food intake per 100 gm of body weight in rat at 106 ug/kg, sc after 6 hrs ChEMBL. 18193826
IC50 (binding) = 34 nM Displacement of 125I-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells ChEMBL. 18193826
IC50 (binding) = 34 nM Displacement of 125I-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells ChEMBL. 18193826
Kb (functional) = 14 nM Antagonist activity at GHSR1a (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin induced accumulation of intracellular calcium ChEMBL. 18193826
Kb (functional) = 14 nM Antagonist activity at GHSR1a (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin induced accumulation of intracellular calcium ChEMBL. 18193826

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.