Detailed information for compound 576486

Basic information

Technical information
  • TDR Targets ID: 576486
  • Name: sodium (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetrae noate
  • MW: 326.449 | Formula: C20H31NaO2
  • H donors: 0 H acceptors: 2 LogP: 6.94 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)[O-].[Na+]
  • InChi: 1S/C20H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22);/q;+1/p-1/b7-6-,10-9-,13-12-,16-15-;
  • InChiKey: DDMGAAYEUNWXSI-XVSDJDOKSA-M  


Substructure search Similarity search

Network

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Synonyms

  • Arachidonic Acid
  • 6610-25-9
  • 5,8,11,14-Eicosatetraenoic acid, sodium salt, (all-Z)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cytochrome P450 1A2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 1A2   513 aa 512 aa 21.1 %
Candida albicans cytochrome P450 similar to phenylacetate hydroxylase Cytochrome P450 1A2   513 aa 539 aa 23.0 %
Drosophila melanogaster shadow Cytochrome P450 1A2   513 aa 485 aa 19.8 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 1A2   513 aa 445 aa 23.6 %
Onchocerca volvulus Cytochrome P450 1A2   513 aa 533 aa 26.3 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 1A2   513 aa 488 aa 25.2 %
Brugia malayi Cytochrome P450 family protein Cytochrome P450 1A2   513 aa 508 aa 26.2 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 1A2   513 aa 499 aa 24.6 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 1A2   513 aa 528 aa 23.5 %
Candida albicans cytochrome P450 lanosterol 14-alpha -demethylase Cytochrome P450 1A2   513 aa 524 aa 21.4 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 1A2   513 aa 537 aa 23.6 %
Loa Loa (eye worm) cytochrome P450 family protein Cytochrome P450 1A2   513 aa 508 aa 27.6 %
Candida albicans cytochrome P450 lanosterol 14-alpha -demethylase Cytochrome P450 1A2   513 aa 524 aa 21.6 %
Candida albicans cytochrome P450 similar to phenylacetate hydroxylase Cytochrome P450 1A2   513 aa 539 aa 23.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0015 0.0011 0.0003
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0065 0.0582
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0059 0.0146
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0084 0.0225 0.2107
Schistosoma mansoni hypothetical protein 0.0029 0.0054 0.0256
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0013 0.0085
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1139 0.3505 0.8711
Entamoeba histolytica hypothetical protein 0.0023 0.0036 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0011 0.0068
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0009
Plasmodium falciparum DNA repair and recombination protein RAD54, putative 0.0024 0.0037 0.1668
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0038 0.0032
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0124 0.0347 0.0341
Brugia malayi PHD-finger family protein 0.0029 0.0054 0.0111
Echinococcus multilocularis Smad4 0.0033 0.0066 0.0059
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0095 0.0235
Loa Loa (eye worm) hypothetical protein 0.0237 0.0701 0.1742
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0015 0.0011 0.0068
Onchocerca volvulus Glucosylceramidase homolog 0.0857 0.2627 0.7491
Trypanosoma brucei DNA repair and recombination protein RAD54, putative 0.0024 0.0037 0.0322
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0186 0.0179
Entamoeba histolytica hypothetical protein 0.0072 0.0186 0.0521
Echinococcus multilocularis dna repair and recombination protein rad54 0.0024 0.0037 0.0031
Schistosoma mansoni Smad4 0.0015 0.0009 0.0045
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0015 0.0011 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0065 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0108
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0073 0.0066
Brugia malayi Bromodomain containing protein 0.0076 0.02 0.0475
Trichomonas vaginalis glucosylceramidase, putative 0.0857 0.2627 0.6527
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0026 0.0043 0.0037
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0015 0.0011 0.0051
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0009 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0351 0.1055 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0015 0.0011 0.0004
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0112 0.0535
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0069 0.0328
Schistosoma mansoni hypothetical protein 0.004 0.0088 0.042
Brugia malayi N-terminal motif family protein 0.0178 0.0516 0.1263
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0084 0.0225 0.0552
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.028
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Brugia malayi MH2 domain containing protein 0.0033 0.0066 0.0141
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0265 0.0637
Loa Loa (eye worm) hypothetical protein 0.0059 0.0148 0.0369
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0026 0.0043 0.0174
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0394 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0011 0.0068
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0206 0.4539
Onchocerca volvulus 0.0026 0.0043 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.1306 0.4023 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0206 0.0518
Trichomonas vaginalis glucosylceramidase, putative 0.1306 0.4023 1
Brugia malayi Bromodomain containing protein 0.0034 0.0068 0.0147
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0065 0.0058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0023
Echinococcus multilocularis mitogen activated protein kinase 0.0153 0.044 0.0434
Schistosoma mansoni hypothetical protein 0.0305 0.0911 0.4336
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.044 0.1088
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0154 0.143
Brugia malayi PHD-finger family protein 0.0053 0.0127 0.0294
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0043 0.0206
Loa Loa (eye worm) PDE1B protein 0.0015 0.0011 0.0027
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0039 0.0086 0.0173
Echinococcus granulosus bloom syndrome protein 0.0024 0.0038 0.0151
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0036 0.008
Echinococcus granulosus microtubule associated protein 2 0.0688 0.2101 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0181
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0018
Brugia malayi isocitrate dehydrogenase 0.0033 0.0065 0.0138
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0026 0.0064
Echinococcus granulosus single minded 2 0.004 0.0087 0.0382
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0071 0.3307
Schistosoma mansoni glutaminase 0.0275 0.0817 0.3888
Brugia malayi hypothetical protein 0.0072 0.0186 0.044
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0153 0.044 0.4155
Trichomonas vaginalis glucosylceramidase, putative 0.0903 0.277 0.6884
Loa Loa (eye worm) nuclear factor I 0.0018 0.002 0.005
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0043 0.0206
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Trichomonas vaginalis glucosylceramidase, putative 0.0857 0.2627 0.6527
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0112 0.0504
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0066 0.0164
Echinococcus multilocularis snurportin 1 0.0305 0.0911 0.0905
Brugia malayi PAS domain containing protein 0.0054 0.013 0.0301
Echinococcus multilocularis cpg binding protein 0.0064 0.0161 0.0154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0174 0.0503 0.2371
Trypanosoma cruzi ISWI complex protein 0.003 0.0058 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0073 0.0346
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0736
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0043 0.0085
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0345
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0041 0.1828
Schistosoma mansoni single-minded 0.0054 0.013 0.0619
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0133 0.0633
Brugia malayi Smad1 0.0033 0.0066 0.0141
Echinococcus multilocularis musashi 0.0031 0.0059 0.0052
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0015 0.0011 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.0666 0.3171
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0073 0.0315
Trichomonas vaginalis glucosylceramidase, putative 0.1306 0.4023 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0198 0.1852
Schistosoma mansoni hypothetical protein 0.0048 0.0114 0.0542
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0043 0.0758
Leishmania major basic transcription factor 3a, putative 0.0034 0.0071 0.0637
Schistosoma mansoni smad 0.0015 0.0009 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0095 0.0451
Loa Loa (eye worm) type III restriction enzyme 0.0024 0.0037 0.0093
Onchocerca volvulus 0.0076 0.0198 0.0547
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0038 0.0087
Loa Loa (eye worm) hypothetical protein 0.0151 0.0433 0.1077
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1139 0.3505 1
Onchocerca volvulus 0.0031 0.0059 0.0148
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0009
Echinococcus granulosus importin subunit beta 1 0.0029 0.0052 0.0217
Leishmania major hypothetical protein, conserved 0.0015 0.0011 0.0068
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0015 0.0011 0.0019
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0141
Loa Loa (eye worm) hypothetical protein 0.0141 0.04 0.0995
Giardia lamblia DNA repair protein RAD52 0.0344 0.1034 0.2928
Schistosoma mansoni hypothetical protein 0.0291 0.0869 0.4134
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0071 0.0167
Plasmodium falciparum phd finger protein, putative 0.0029 0.0054 0.2479
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0124 0.0347 0.0856
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0108
Schistosoma mansoni hypothetical protein 0.003 0.0058 0.0276
Echinococcus granulosus lamin dm0 0.0031 0.0059 0.0247
Onchocerca volvulus 0.0048 0.0112 0.0302
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0122 0.5806
Schistosoma mansoni hypothetical protein 0.004 0.0088 0.042
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0026 0.0209
Leishmania major protein kinase, putative 0.0061 0.0154 0.143
Brugia malayi intermediate filament protein 0.0031 0.0059 0.0123
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.055 0.2595
Trichomonas vaginalis glucosylceramidase, putative 0.0903 0.277 0.6884
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0226 0.0666 0.066
Loa Loa (eye worm) RNA binding protein 0.0061 0.0155 0.0385
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0133 0.0323
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0226 0.0666 0.1656
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.1139 0.3505 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0133 0.0126
Mycobacterium tuberculosis Conserved protein 0.0076 0.0198 0.0568
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.005
Brugia malayi hypothetical protein 0.018 0.0522 0.1278
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0124 0.0347 0.327
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0073 0.0066
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0153 0.044 0.1095
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0198 0.0944
Giardia lamblia Kinase, CMGC CLK 0.0061 0.0154 0.041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0153 0.044 0.4155
Loa Loa (eye worm) hypothetical protein 0.0051 0.0122 0.0303
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.0268 0.0755
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0154 0.143
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0015 0.0011 0.0051
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.1463 0.5956
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.055 0.0544
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0015 0.0011 0.0345
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0198 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0093
Leishmania major hypothetical protein, conserved 0.0076 0.0198 0.1852
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0015 0.0011 0.0051
Toxoplasma gondii hypothetical protein 0.0027 0.0047 0.0844
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0061 0.0154 0.0383
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Toxoplasma gondii hypothetical protein 0.0026 0.0043 0.0758
Schistosoma mansoni hypothetical protein 0.0167 0.0482 0.2295
Loa Loa (eye worm) RecQ helicase 0.0024 0.0038 0.0096
Loa Loa (eye worm) hypothetical protein 0.0076 0.0198 0.0493
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0226 0.0666 0.3149
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0015 0.0011 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0024
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0153 0.044 0.4155
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0736
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0015 0.0037
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0009
Echinococcus multilocularis mitogen activated protein kinase 3 0.0153 0.044 0.0434
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0154 0.0733
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0015 0.0011 0.0019
Plasmodium vivax DNA repair protein RAD54, putative 0.0024 0.0037 0.1668
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0015 0.0011 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.013
Echinococcus granulosus mitogen activated protein kinase 0.0153 0.044 0.2071
Trypanosoma cruzi ISWI complex protein 0.003 0.0058 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0347 0.0856
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0198 0.0914
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0122 0.0116
Schistosoma mansoni Smad4 0.0033 0.0066 0.0315
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0154 0.0733
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Mycobacterium ulcerans glutaminase 0.0275 0.0817 0.2275
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0015 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0198 0.0568
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0015 0.0036
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0084 0.0225 0.0552
Loa Loa (eye worm) transcription factor SMAD2 0.0484 0.1468 0.365
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0007 0.0031
Brugia malayi hypothetical protein 0.0237 0.0701 0.1722
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0226 0.0666 0.066
Brugia malayi hypothetical protein 0.0026 0.0043 0.0085
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Entamoeba histolytica hypothetical protein 0.0034 0.0071 0.0191
Entamoeba histolytica DNA repair protein, putative 0.0024 0.0037 0.0097
Schistosoma mansoni hypothetical protein 0.0174 0.0503 0.2396
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1139 0.3505 0.8711
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1139 0.3505 0.8711
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.0516 0.1456
Brugia malayi hypoxia-induced factor 1 0.0166 0.0479 0.117
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0549 0.167 0.4151
Treponema pallidum sodium- and chloride- dependent transporter 0.0151 0.0433 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0113 0.0106
Echinococcus multilocularis 0.0059 0.0148 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.044 0.1088
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0026 0.0043 0.0037
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0015 0.0008
Trichomonas vaginalis esterase, putative 0.0076 0.0198 0.0485
Loa Loa (eye worm) MH2 domain-containing protein 0.0484 0.1468 0.365
Brugia malayi RNA, U transporter 1 0.0081 0.0216 0.0515
Echinococcus granulosus cpg binding protein 0.0064 0.0161 0.0737
Brugia malayi MH2 domain containing protein 0.0033 0.0066 0.0141
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Schistosoma mansoni hypothetical protein 0.0072 0.0186 0.0884
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0375 0.113 0.2809
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0122 0.0245
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0047 0.202
Echinococcus multilocularis dna repair and recombination protein rad54 0.0024 0.0037 0.0031
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0015 0.0011 0.0027
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0095 0.042
Onchocerca volvulus 0.0026 0.0043 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.1306 0.4023 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0345
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0066 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.0666 0.3171
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.0342 0.0336
Onchocerca volvulus 0.004 0.0087 0.0229
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0029 0.1267
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0113 0.0537
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0394 0.185
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0112 0.0106
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0206 1
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0011 0.0068
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0007 0.0009
Echinococcus multilocularis dual specificity protein kinase clk2 0.0061 0.0154 0.0147
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0153 0.044 0.4155
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0007 0.0017
Onchocerca volvulus 0.0076 0.0198 0.0547
Mycobacterium tuberculosis Conserved protein 0.0076 0.0198 0.0568
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0043 0.0758
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0065 0.1258
Trichomonas vaginalis glucosylceramidase, putative 0.0857 0.2627 0.6527
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0198 0.0485
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0015 0.0011 0.0051
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0198 0.0493
Echinococcus multilocularis smad 0.0033 0.0066 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.03 0.0739
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0069 0.0328
Brugia malayi Bromodomain containing protein 0.0152 0.0437 0.1065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0018 0.0053
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0108
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0206 0.095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0037 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.0857 0.2627 0.6527
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0024 0.0037 0.0322
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0061 0.0154 0.143
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0017
Echinococcus granulosus lamin 0.0031 0.0059 0.0247
Trichomonas vaginalis glucosylceramidase, putative 0.1306 0.4023 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0206 0.4539
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0198 0.0944
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0015 0.0011 0.0068
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0054 0.0256
Schistosoma mansoni importin beta-1 0.0029 0.0052 0.0249
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0206 1
Schistosoma mansoni zinc finger protein 0.003 0.0058 0.0276
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0186 0.0855
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0259 0.0253
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0043 0.0085
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0052 0.0967
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0026 0.0209
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0054 0.0047
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0047 0.214
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0015 0.0011 0.0068
Echinococcus multilocularis lamin 0.0031 0.0059 0.0052
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0015 0.0011 0.0068
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0049 0.0233
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0198 0.0568
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0198 0.0485
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0113 0.0506
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0015 0.0011 0.0004
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0133 0.0308
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0345
Brugia malayi Cytochrome P450 family protein 0.002 0.0026 0.004
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0055 0.0133 0.0308
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0.0043 0.0085
Echinococcus multilocularis protein dispatched 1 0.0047 0.0111 0.0104
Brugia malayi mbt repeat family protein 0.0048 0.0112 0.0257
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0788 0.2413 1
Toxoplasma gondii hypothetical protein 0.0039 0.0086 0.1748
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0154 0.143
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0043 0.0108
Schistosoma mansoni hypothetical protein 0.0403 0.1216 0.5786
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0206 1
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0024 0.0037 0.0322
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0066 0.0059
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0066 0.0164
Echinococcus granulosus mitogen activated protein kinase 3 0.0153 0.044 0.2071
Echinococcus multilocularis GPCR, family 2 0.0174 0.0503 0.0497
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0345
Brugia malayi Latrophilin receptor protein 2 0.0174 0.0503 0.1231
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.044 0.2096
Trichomonas vaginalis glutaminase, putative 0.0275 0.0817 0.2024
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0093 0.0223
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0007 0.0009
Plasmodium falciparum transporter, putative 0.0026 0.0043 0.1957
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0043 0.0174
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0059 0.0123
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0013 0.0085
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0112 0.0106
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0112 0.0504
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0024 0.0037 0.0178
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0112 0.0535
Echinococcus granulosus SPRY domain containing protein 0.0024 0.0037 0.0146
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0351 0.1055 1
Trichomonas vaginalis glucosylceramidase, putative 0.1306 0.4023 1
Echinococcus granulosus SPRY domain containing protein 0.0024 0.0037 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0226 0.0666 0.3149
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0086 0.4063
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0065 0.0058
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0198 0.0485
Brugia malayi beta-lactamase 0.0076 0.0198 0.0471
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Loa Loa (eye worm) MBCTL1 0.0055 0.0133 0.0331
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0206 0.0199
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1139 0.3505 1
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0198 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0205
Schistosoma mansoni cpg binding protein 0.0064 0.0161 0.0767
Trypanosoma brucei ISWI complex protein 0.003 0.0058 0.0518
Brugia malayi MH1 domain containing protein 0.0018 0.002 0.0027
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0087 0.008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0036 0.0304
Trypanosoma brucei cytochrome P450, putative 0.002 0.0026 0.0209
Plasmodium vivax phosphodiesterase gamma, putative 0.0015 0.0011 0.0345
Brugia malayi beta-lactamase family protein 0.0076 0.0198 0.0471
Echinococcus granulosus dnaJ subfamily B 0.0403 0.1216 0.5772
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1139 0.3505 0.8711
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0059 0.0123
Echinococcus multilocularis transcription factor btf3 0.0034 0.0071 0.0064
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0009 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0011 0.0068
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0198 0.0485
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0066 0.0059
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0153 0.044 0.4155
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.1139 0.3505 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0133 0.0323
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0294
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0154 0.143
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0185 0.0853
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0041 0.0353
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0015 0.0011 0.0051
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0047 0.214
Echinococcus multilocularis geminin 0.0167 0.0482 0.0476
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0153 0.044 1
Mycobacterium ulcerans beta-lactamase 0.0076 0.0198 0.0496
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0065 0.0058
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0015 0.0011 0.0004
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Echinococcus multilocularis 0.0024 0.0037 0.0031
Plasmodium falciparum phosphodiesterase delta, putative 0.0015 0.0011 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.0666 0.3171
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0071 0.0191
Loa Loa (eye worm) glutaminase 0.0275 0.0817 0.2031
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0151 0.0433 0.2063
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0071 0.0637
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0043 0.0108
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0015 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0076 0.0198 0.0493
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0198 0.1852
Trichomonas vaginalis glucosylceramidase, putative 0.0857 0.2627 0.6527
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0009 0.0013
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0015 0.0011 0.0018
Echinococcus granulosus transcription factor btf3 0.0034 0.0071 0.0304
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.008
Echinococcus multilocularis zinc finger protein 0.0042 0.0094 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0736
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.1216 0.121
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0071 0.0175
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0052 0.0463
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0151 0.0433 0.1057
Mycobacterium leprae Probable lipase LipE 0.0076 0.0198 0.9623
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0124 0.0347 0.1654
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0351 0.1055 0.2617
Schistosoma mansoni bromodomain containing protein 0.0129 0.0364 0.1734
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0026 0.0043 0.1834
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0071 0.0637
Loa Loa (eye worm) hypothetical protein 0.0078 0.0206 0.0512
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0093
Loa Loa (eye worm) glutaminase 2 0.0275 0.0817 0.2031
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0122 0.0245
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0038 0.0073
Loa Loa (eye worm) hypothetical protein 0.0076 0.0198 0.0493
Toxoplasma gondii ABC1 family protein 0.0076 0.0198 0.4364
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0015 0.0011 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0007 0.0002
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0043 0.0206
Echinococcus granulosus dual specificity protein kinase clk2 0.0061 0.0154 0.0703
Brugia malayi mbt repeat family protein 0.0048 0.0112 0.0257
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0133 0.0126
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0015 0.0011 0.0345
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0206 0.4109
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0086 0.0173
Echinococcus granulosus intermediate filament protein 0.0031 0.0059 0.0247
Schistosoma mansoni hypothetical protein 0.0041 0.0091 0.0433
Giardia lamblia PHD finger protein 15 0.0029 0.0054 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0071 0.0167
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.1139 0.3505 0.8709
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0043 0.0758
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0015 0.0011 0.0068
Onchocerca volvulus 0.0057 0.0139 0.0379
Loa Loa (eye worm) hypothetical protein 0.0151 0.0433 0.1077
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0055 0.0133 0.0308
Schistosoma mansoni transcription factor btf3 0.0034 0.0071 0.0336
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0024 0.0037 0.0178
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Loa Loa (eye worm) hypothetical protein 0.0076 0.0198 0.0493
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0019
Leishmania major hypothetical protein, conserved 0.0015 0.0011 0.0068
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0043 0.0037
Echinococcus multilocularis lamin dm0 0.0031 0.0059 0.0052
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0026 0.0043 0.0037
Loa Loa (eye worm) hypoxia-induced factor 1 0.0166 0.0479 0.119
Echinococcus granulosus expressed conserved protein 0.0091 0.0247 0.1145
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0041 0.0353
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0069 0.0296
Echinococcus multilocularis expressed conserved protein 0.0091 0.0247 0.024
Schistosoma mansoni sodium/chloride dependent transporter 0.0151 0.0433 0.2063
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0043 0.0206
Mycobacterium ulcerans lipase LipD 0.0076 0.0198 0.0496
Leishmania major cytochrome p450-like protein 0.002 0.0026 0.0209
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.1139 0.3505 0.8712
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0043 0.0174
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0055 0.0133 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0549 0.167 0.4137
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0007 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0043 0.1957
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0011 0.0068
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0155 0.0148
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0054 0.1003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0015 0.0011 0.0051
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0198 0.1852
Loa Loa (eye worm) hypothetical protein 0.0055 0.0133 0.0331
Echinococcus multilocularis 0.0024 0.0037 0.0031
Onchocerca volvulus 0.0048 0.0114 0.0306
Brugia malayi RNA binding protein 0.0061 0.0155 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.03 0.0739
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0043 0.0085
Schistosoma mansoni cpg binding protein 0.0057 0.0139 0.0663
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0043 0.0206
Brugia malayi beta-lactamase family protein 0.0076 0.0198 0.0471
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0093 0.0411
Trypanosoma brucei protein kinase, putative 0.0153 0.044 0.4155
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0108
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0133 0.0603
Trichomonas vaginalis glucosylceramidase, putative 0.0857 0.2627 0.6527
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0086 0.0173
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0068
Echinococcus granulosus smad 0.0033 0.0066 0.0283
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0015 0.0011 0.0068
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0018
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0043 0.0206
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0155 0.0385
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0038 0.0087
Plasmodium falciparum protein serine/threonine kinase-1 0.0061 0.0154 0.7435
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0086 0.3973
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0589
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0199 0.0945
Plasmodium falciparum phosphodiesterase gamma, putative 0.0015 0.0011 0.0345
Toxoplasma gondii GAF domain-containing protein 0.0039 0.0086 0.1748
Echinococcus multilocularis SPRY domain containing protein 0.0024 0.0037 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0174 0.0503 0.0497
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0093 0.0411
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0009
Leishmania major DNA repair and recombination protein RAD54, putative 0.0024 0.0037 0.0322
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0015 0.0011 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0095 0.0451
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0093 0.0086
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0155 0.0362
Brugia malayi Cytochrome P450 family protein 0.002 0.0026 0.004
Brugia malayi recombination factor GdRad54 0.0024 0.0037 0.007
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.013 0.0619
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0041 0.1828
Entamoeba histolytica hypothetical protein 0.0072 0.0186 0.0521
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0071 0.3307
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0054 0.2479
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0026 0.0043 0.0174
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0857 0.2627 0.6527
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0013 0.0085
Entamoeba histolytica hypothetical protein 0.0098 0.0268 0.0755
Schistosoma mansoni hypothetical protein 0.0174 0.0503 0.2396
Giardia lamblia Kinase, CMGC MAPK 0.0153 0.044 0.123
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.008
Leishmania major protein kinase, putative 0.0016 0.0013 0.0085
Schistosoma mansoni hypothetical protein 0.004 0.0088 0.042
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0015 0.0011 0.0051
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0139 0.0346
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0039 0.0086 0.009
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0007 0.0031
Brugia malayi MAP kinase sur-1 0.0153 0.044 0.1074
Loa Loa (eye worm) hypothetical protein 0.0549 0.167 0.4151
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0108
Loa Loa (eye worm) hypothetical protein 0.0174 0.0503 0.1251
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0206 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0153 0.044 0.4155
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0226 0.0666 0.1637
Loa Loa (eye worm) CYP4Cod1 0.002 0.0026 0.0064
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0014 0.0067
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0093
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0015 0.0011 0.0018
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0065 0.0582
Loa Loa (eye worm) hypothetical protein 0.0076 0.0201 0.0498
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.2101 0.2096
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0351 0.1055 0.2617
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.044 0.1088
Schistosoma mansoni patched 1 0.0042 0.0093 0.0442
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0198 0.0568
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0043 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0071 0.0167
Brugia malayi Protein kinase domain containing protein 0.0061 0.0154 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0351 0.1055 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0015 0.0011 0.0003
Brugia malayi CHE-14 protein 0.0042 0.0093 0.0208
Echinococcus granulosus zinc finger protein 0.0042 0.0094 0.0418
Loa Loa (eye worm) hypothetical protein 0.018 0.0522 0.1298
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0155 0.0385
Echinococcus granulosus Smad4 0.0033 0.0066 0.0283
Schistosoma mansoni cpg binding protein 0.0064 0.0161 0.0767
Loa Loa (eye worm) beta-lactamase 0.0076 0.0198 0.0493
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0185 0.0179
Schistosoma mansoni survival motor neuron protein 0.0048 0.0114 0.0542
Schistosoma mansoni sodium-dependent amino acid transporter 0.0026 0.0043 0.0206
Brugia malayi hypothetical protein 0.0016 0.0013 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0154 0.0375
Schistosoma mansoni lamin 0.0031 0.0059 0.0279
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0076 0.0198 0.0493
Plasmodium vivax serine/threonine kinase-1, putative 0.0061 0.0154 0.7435
Plasmodium falciparum GAF domain-related protein, putative 0.0039 0.0086 0.4063
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0124 0.0347 0.0856
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0265 0.0258
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0336 0.1601
Echinococcus multilocularis peregrin 0.0034 0.0068 0.0062
Onchocerca volvulus 0.0076 0.0198 0.0547
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0071 0.0637
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0055 0.0133 0.0633
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0043 0.0206
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0213
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0065 0.0582
Loa Loa (eye worm) hypothetical protein 0.0042 0.0093 0.0231
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0198 0.0471
Mycobacterium ulcerans putative regulatory protein 0.004 0.0087 0.0176
Leishmania major cAMP-specific phosphodiesterase, putative 0.0015 0.0011 0.0068
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0015 0.0011 0.0019
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0015 0.0011 0.0019
Toxoplasma gondii hypothetical protein 0.0026 0.0043 0.0758
Brugia malayi bHLH-PAS transcription factor 0.004 0.0087 0.0193
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0065 0.0309
Mycobacterium ulcerans hypothetical protein 0.0076 0.0198 0.0496
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0066 0.0283
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0065 0.0277
Schistosoma mansoni intermediate filament proteins 0.0031 0.0059 0.0279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0134
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Brugia malayi CXXC zinc finger family protein 0.0057 0.0139 0.0324
Loa Loa (eye worm) hypothetical protein 0.0081 0.0215 0.0535
Mycobacterium tuberculosis Conserved protein 0.0076 0.0198 0.0568
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0198 0.0568
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0101
Schistosoma mansoni hypothetical protein 0.0174 0.0503 0.2396
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0345
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1139 0.3505 0.8711
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0124 0.0347 0.327
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0122 0.0552
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0065 0.0058
Loa Loa (eye worm) hypothetical protein 0.0121 0.0341 0.0847
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0073 0.0181
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.0701 0.0694
Echinococcus granulosus serotonin transporter 0.0151 0.0433 0.2037
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0065 0.3022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0198 0.0568
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0013 0.0085
Echinococcus multilocularis protein patched 0.0042 0.0093 0.0086
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0093 0.0231
Entamoeba histolytica DNA repair protein, putative 0.0024 0.0037 0.0097
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0265 0.1232
Brugia malayi beta-NAC-like protein 0.0034 0.0071 0.0153
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0066 0.0315
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0124 0.0347 0.0856
Echinococcus granulosus GPCR family 2 0.0174 0.0503 0.2371
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0054 0.0225
Leishmania major importin beta-1 subunit, putative 0.0023 0.0036 0.0304
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0009
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0009 0.0003
Onchocerca volvulus 0.1139 0.3505 1
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0059 0.0146
Echinococcus granulosus peregrin 0.0034 0.0068 0.0294
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0112 0.0535
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0112 0.0302
Echinococcus granulosus jumonji domain containing protein 0.004 0.0089 0.0393
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0124 0.0347 0.0856
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.0342 0.1602
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0043 0.0206
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0026 0.0064
Brugia malayi TAR-binding protein 0.0061 0.0155 0.0362
Schistosoma mansoni Smad4 0.0015 0.0009 0.0045
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0024 0.0037 0.0146
Schistosoma mansoni zinc finger protein 0.0042 0.0094 0.045
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0206 0.0979
Plasmodium falciparum amino acid transporter, putative 0.0026 0.0043 0.1957
Onchocerca volvulus 0.0026 0.0043 0.0104
Schistosoma mansoni hypothetical protein 0.0375 0.113 0.5378
Brugia malayi Probable ClpP-like protease 0.0078 0.0206 0.0489
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0124 0.0347 0.327
Plasmodium vivax amine transporter, putative 0.0026 0.0043 0.1957
Brugia malayi jmjC domain containing protein 0.0042 0.0095 0.0213
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0153 0.044 0.4155
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.03 0.0739
Onchocerca volvulus 0.0151 0.0433 0.122
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0054 0.0134
Loa Loa (eye worm) hypothetical protein 0.0076 0.0198 0.0493
Schistosoma mansoni smad 0.0033 0.0066 0.0315
Loa Loa (eye worm) norepinephrine transporter 0.0151 0.0433 0.1077
Echinococcus granulosus SPRY domain containing protein 0.0024 0.0037 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0011 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0198 0.0568
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0043 0.0174
Loa Loa (eye worm) hypothetical protein 0.0097 0.0265 0.0659
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0009 0.0012
Echinococcus granulosus geminin 0.0167 0.0482 0.227
Schistosoma mansoni lamin 0.0031 0.0059 0.0279
Loa Loa (eye worm) hypothetical protein 0.0151 0.0433 0.1077
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0198 0.0485
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0037 0.007
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.027 0.1283
Echinococcus multilocularis SPRY domain containing protein 0.0024 0.0037 0.0031
Leishmania major protein kinase, putative 0.0061 0.0154 0.143
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0167 0.0482 0.2295
Entamoeba histolytica hypothetical protein 0.0072 0.0186 0.0521
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0043 0.0206
Onchocerca volvulus 0.0031 0.0059 0.0148
Loa Loa (eye worm) hypothetical protein 0.0055 0.0133 0.0331
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0065 0.0582
Echinococcus granulosus tar DNA binding protein 0.0061 0.0155 0.0706
Loa Loa (eye worm) serotonin transporter b 0.0151 0.0433 0.1077
Schistosoma mansoni smad1 5 8 and 0.0033 0.0066 0.0315
Brugia malayi MH2 domain containing protein 0.0484 0.1468 0.3635
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0011 0.0068
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0133 0.0603
Echinococcus granulosus dna repair and recombination protein rad54 0.0024 0.0037 0.0146
Loa Loa (eye worm) hypothetical protein 0.0178 0.0516 0.1283
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0052 0.0463
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0069 0.0062
Leishmania major protein kinase, putative 0.002 0.0024 0.0199
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0198 0.9623
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0091 0.0226
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0041 0.1828
Loa Loa (eye worm) latrophilin receptor protein 2 0.0174 0.0503 0.1251
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0133 0.0323
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0206 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0011 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0736
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0054 0.1003
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0065 0.1258
Loa Loa (eye worm) Smad1 0.0033 0.0066 0.0164
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0065 0.0161
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0174 0.0503 0.2371
Toxoplasma gondii hypothetical protein 0.0039 0.0086 0.1748
Plasmodium falciparum importin beta, putative 0.0029 0.0052 0.2402
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.0911 0.2265
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0198 0.0568
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0015 0.0011 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0093
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.2101 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0259 0.1206
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1306 0.4023 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0206 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0736
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0198 0.9629
Brugia malayi latrophilin 2 splice variant baaae 0.0375 0.113 0.2792
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0198 0.0192
Brugia malayi Calcitonin receptor-like protein seb-1 0.0549 0.167 0.4137
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0004 0.0001
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1139 0.3505 0.8711
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.015 0.0373
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0039 0.0086 0.009
Brugia malayi glutaminase DH11.1 0.0275 0.0817 0.2012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0146
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0043 0.0174
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0015 0.0011 0.0019
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0065 0.0138
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0124 0.0347 0.1627
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0009 0.0023
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0065 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0009
Echinococcus granulosus hypothetical protein 0.0059 0.0148 0.0675
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0089 0.0082
Schistosoma mansoni smad1 5 8 and 0.0033 0.0066 0.0315
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0071 0.1392
Brugia malayi jmjC domain containing protein 0.0095 0.0259 0.0623
Schistosoma mansoni hypothetical protein 0.0174 0.0503 0.2396
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0011 0.0068
Brugia malayi MH1 domain containing protein 0.0033 0.0066 0.0141
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0112 0.028
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0041 0.0697
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0014 0.0517
Brugia malayi MH1 domain containing protein 0.0018 0.002 0.0027
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0265 0.0747
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0311 0.699
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.0701 0.3313
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0186 0.0884
Brugia malayi MH1 domain containing protein 0.0033 0.0066 0.0141
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0124 0.0347 0.327
Entamoeba histolytica hypothetical protein 0.0072 0.0186 0.0521
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0015 0.0011 0.0068
Brugia malayi hypothetical protein 0.0025 0.0041 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0041 0.0353
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0052 0.0046
Onchocerca volvulus Alhambra homolog 0.0029 0.0054 0.0134
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0174 0.0503 0.0497
Plasmodium vivax importin-beta 2, putative 0.0029 0.0052 0.2402
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0206 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0011 0.0068
Schistosoma mansoni hypothetical protein 0.004 0.0088 0.042
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0055 0.0133 0.0603
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1306 0.4023 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0023 0.0108
Brugia malayi Importin beta-1 subunit 0.0029 0.0052 0.0107
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0061 0.0154 0.3333
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0174 0.0503 0.1231
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0009 0.0003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0065 0.3022
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0061 0.0154 0.143
Echinococcus multilocularis dna repair and recombination protein rad54 0.0024 0.0037 0.0031
Echinococcus multilocularis serotonin transporter 0.0151 0.0433 0.0427
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0114 0.026
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0015 0.0011 0.0004
Toxoplasma gondii hypothetical protein 0.0108 0.03 0.6738
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0018 0.0045
Leishmania major hypothetical protein, conserved 0.0351 0.1055 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0344 0.1034 0.2942
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.044 0.1088
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0009 0.0007
Leishmania major hypothetical protein, conserved 0.0025 0.0041 0.0353
Brugia malayi PHD-finger family protein 0.0017 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0108
Schistosoma mansoni smad1 5 8 and 0.0033 0.0066 0.0315
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0037
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0124 0.0347 0.327
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0015 0.0011 0.0018
Echinococcus granulosus snurportin 1 0.0305 0.0911 0.4317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0073 0.0346
Leishmania major hypothetical protein, conserved 0.003 0.0058 0.0518
Loa Loa (eye worm) solute carrier family 6 member 4 0.0151 0.0433 0.1077
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0015 0.0011 0.0018

Activities

Activity type Activity value Assay description Source Reference
Ki (ADMET) = 4.7 uM Competitive inhibition of rat recombinant CYP1A2 expressed in Escherichia coli assessed as inhibition of PHEN O-deethylation by dixon plot analysis ChEMBL. 22331994

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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