Detailed information for compound 605775

Basic information

Technical information
  • TDR Targets ID: 605775
  • Name: N2-naphthalen-1-yl-N4,N6-bis[(3-nitrophenyl)m ethylideneamino]-1,3,5-triazine-2,4,6-triamin e
  • MW: 548.512 | Formula: C27H20N10O4
  • H donors: 3 H acceptors: 7 LogP: 6.66 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-][N+](=O)c1cccc(c1)C=NNc1nc(N/N=C/c2cccc(c2)[N+](=O)[O-])nc(n1)Nc1cccc2c1cccc2
  • InChi: 1S/C27H20N10O4/c38-36(39)21-10-3-6-18(14-21)16-28-34-26-31-25(30-24-13-5-9-20-8-1-2-12-23(20)24)32-27(33-26)35-29-17-19-7-4-11-22(15-19)37(40)41/h1-17H,(H3,30,31,32,33,34,35)/b28-16+,29-17+
  • InChiKey: FWAKGPQUGMQZHW-LPHFKDDMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N2-(1-naphthyl)-N4,N6-bis[(3-nitrophenyl)methyleneamino]-1,3,5-triazine-2,4,6-triamine
  • [4,6-bis[N'-(3-nitrobenzylidene)hydrazino]-s-triazin-2-yl]-(1-naphthyl)amine
  • [4,6-bis[(N'E)-N'-(3-nitrobenzylidene)hydrazino]-s-triazin-2-yl]-(1-naphthyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.008 0.0869
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0024 0.0051 0.0554
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0064 0.0205
Entamoeba histolytica aldose reductase, putative 0.0197 0.0917 0.6744
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0087 0.0364 0.1162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.002 0.0064
Schistosoma mansoni coup transcription factor 0.0087 0.0364 0.1107
Schistosoma mansoni tyrosine kinase 0.0046 0.016 0.0488
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0024 0.0051 0.0554
Echinococcus multilocularis neuropeptide receptor 0.0106 0.0462 0.0922
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0134 0.0407
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0215 0.0653
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0106 0.0462 0.1406
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0087 0.0364 0.1162
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0187
Brugia malayi nuclear hormone receptor 0.0041 0.0134 0.0427
Plasmodium vivax JmjC domain containing protein 0.0015 0.0005 0.0056
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0054 0.0584
Schistosoma mansoni amine GPCR 0.0106 0.0462 0.1406
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Onchocerca volvulus Putative protein 0.0043 0.0145 0.0463
Echinococcus granulosus FTZ F1 alpha 0.0087 0.0364 0.0364
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0054 0.0171
Brugia malayi Cytochrome P450 family protein 0.0024 0.0051 0.0162
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0187 0.0864 0.9426
Onchocerca volvulus 0.0197 0.0917 0.293
Echinococcus multilocularis allatostatin A receptor 0.0106 0.0462 0.0922
Entamoeba histolytica aldose reductase, putative 0.0197 0.0917 0.6744
Plasmodium vivax flavodoxin domain containing protein 0.0023 0.0044 0.0506
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0026 0.0059 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0364 0.0725
Schistosoma mansoni aryl hydrocarbon receptor 0.0096 0.041 0.1247
Brugia malayi Calcium binding EGF domain containing protein 0.0058 0.0219 0.0701
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0076 0.0335
Brugia malayi dehydrogenases, short chain protein 2 0.0043 0.0144 0.0461
Echinococcus multilocularis FTZ F1 alpha 0.0087 0.0364 0.0725
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0109 0.0474 0.2086
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0008
Brugia malayi Cytochrome P450 family protein 0.0024 0.0051 0.0162
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0215 0.0428
Echinococcus multilocularis lamin 0.0053 0.0195 0.039
Schistosoma mansoni notch 0.0058 0.0219 0.0667
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Schistosoma mansoni loxhd1 0.0038 0.012 0.0366
Brugia malayi Nuclear hormone receptor-like 1 0.0087 0.0364 0.1162
Echinococcus multilocularis neuropeptide Y receptor 0.0106 0.0462 0.0922
Schistosoma mansoni hypothetical protein 0.0106 0.0462 0.1406
Entamoeba histolytica hypothetical protein 0.0035 0.0104 0.0628
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Schistosoma mansoni potassium channel beta 0.0109 0.0474 0.1442
Brugia malayi Dopamine receptor 0.0106 0.0462 0.1476
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0195 0.0624
Schistosoma mansoni adenoreceptor 0.0106 0.0462 0.1406
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0364 0.0725
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0043 0.0145 0.0463
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0001 0.0012
Leishmania major protein kinase, putative 0.0025 0.0054 0.0584
Onchocerca volvulus Putative cubilin 0.0058 0.0219 0.0701
Trypanosoma cruzi aldo/keto reductase, putative 0.0109 0.0474 0.5167
Trypanosoma cruzi MFS transporter, putative 0.0027 0.0064 0.0699
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0335
Trypanosoma brucei aldo/keto reductase, putative 0.0109 0.0474 0.5167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0401
Onchocerca volvulus 0.0041 0.0134 0.0427
Onchocerca volvulus Peroxidase homolog 0.0639 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0158 0.0506
Mycobacterium ulcerans glyoxalase GloA 0.0043 0.0145 0.1582
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0005 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0047 0.0205
Mycobacterium ulcerans hypothetical protein 0.0109 0.0474 0.5167
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0134 0.0427
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Brugia malayi NADH-dependent xylose reductase 0.0109 0.0474 0.1514
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.002 0.0231
Loa Loa (eye worm) doublecortin family protein 0.0038 0.012 0.0384
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0462 0.0922
Schistosoma mansoni rab6-interacting 0.0038 0.012 0.0366
Giardia lamblia DINP protein human, muc B family 0.002 0.0031 0.023
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0026 0.0059 0.0677
Echinococcus granulosus intermediate filament protein 0.0053 0.0195 0.0195
Brugia malayi neuropeptide F receptor 0.0106 0.0462 0.1476
Echinococcus granulosus aldehyde reductase 0.0088 0.0372 0.0372
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0 0.0002
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0109 0.0474 0.5167
Loa Loa (eye worm) animal heme peroxidase 0.0639 0.3131 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0002 0.0006
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0026 0.0059 0.0059
Schistosoma mansoni opsin-like receptor 0.0106 0.0462 0.1406
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0215 0.0215
Onchocerca volvulus 0.0043 0.0144 0.0461
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0067
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0475 0.0948
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0054 0.0054
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0106 0.0462 0.0922
Echinococcus multilocularis lamin dm0 0.0053 0.0195 0.039
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.0043 0.0145 0.0463
Schistosoma mansoni histamine h1 receptor 0.0106 0.0462 0.1406
Brugia malayi M-phase phosphoprotein, mpp8 0.0098 0.0421 0.1345
Mycobacterium tuberculosis Conserved protein 0.0043 0.0145 0.1582
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.135 0.5943
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0024 0.0051 0.0554
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0183 0.0843 0.0843
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0024 0.0051 0.0554
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0147 0.1604
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0753 0.2405
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0024 0.0051 0.0554
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0106 0.0462 0.0922
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1185 0.5215
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0106 0.0462 0.0922
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Schistosoma mansoni intermediate filament proteins 0.0053 0.0195 0.0594
Loa Loa (eye worm) oxidoreductase 0.0197 0.0917 0.293
Entamoeba histolytica hypothetical protein 0.0035 0.0104 0.0628
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0104 0.0315
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Onchocerca volvulus 0.0098 0.0421 0.1345
Onchocerca volvulus 0.0043 0.0144 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.135 0.5943
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Leishmania major DNA polymerase kappa, putative 0.002 0.0031 0.0338
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0197 0.0917 0.293
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0623 0.6606
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0005 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0401
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Brugia malayi Animal haem peroxidase family protein 0.0639 0.3131 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0024 0.0051 0.0554
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0128 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0059 0.026
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.135 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0335
Toxoplasma gondii cytochrome p450 superfamily protein 0.0024 0.0051 0.0554
Echinococcus granulosus biogenic amine 5HT receptor 0.0106 0.0462 0.0462
Echinococcus multilocularis fat cadherin tumor suppressor 0.0058 0.0219 0.0437
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0475 0.2091
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus multilocularis follistatin 0.0018 0.0021 0.0042
Schistosoma mansoni single-minded 0.0096 0.041 0.1247
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0106 0.0462 0.0922
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0058 0.0219 0.0701
Echinococcus multilocularis aldehyde reductase 0.0088 0.0372 0.0741
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0384
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0024 0.0051 0.0554
Mycobacterium ulcerans hypothetical protein 0.0043 0.0145 0.1582
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.007 0.031
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0205
Onchocerca volvulus Peroxidasin homolog 0.0639 0.3131 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0087 0.0364 0.1162
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0335
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0106 0.0462 0.1406
Schistosoma mansoni notch 0.0058 0.0219 0.0667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0015
Echinococcus multilocularis serotonin receptor 0.0106 0.0462 0.0922
Mycobacterium ulcerans hypothetical protein 0.0043 0.0145 0.1582
Onchocerca volvulus 0.0038 0.012 0.0384
Schistosoma mansoni hypothetical protein 0.0024 0.0051 0.0155
Schistosoma mansoni ap endonuclease 0.0018 0.002 0.0061
Onchocerca volvulus 0.0639 0.3131 1
Brugia malayi neuropeptide F receptor 0.0106 0.0462 0.1476
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0106 0.0462 0.0922
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0051 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0401
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0045
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0128 0.1399
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.135 1
Brugia malayi Dopamine receptor protein 2 0.0106 0.0462 0.1476
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0064 0.0205
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.002 0.0218
Echinococcus granulosus aldo keto reductase 0.0197 0.0917 0.0917
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0024 0.0051 0.0554
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0024 0.0051 0.0554
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0134 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0058 0.0255
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Loa Loa (eye worm) hypothetical protein 0.0087 0.0364 0.1162
Echinococcus granulosus microtubule associated protein 2 0.067 0.3286 0.3286
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0015
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0106 0.0462 0.1406
Entamoeba histolytica alcohol dehydrogenase, putative 0.0109 0.0474 0.3412
Echinococcus multilocularis g protein coupled receptor 0.0106 0.0462 0.0922
Echinococcus granulosus fatty acid binding protein FABP2 0.0033 0.0096 0.0096
Schistosoma mansoni polycystin 1-related 0.0038 0.012 0.0366
Plasmodium vivax aldehyde reductase, putative 0.0109 0.0474 0.5482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0054 0.0236
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0475 0.2091
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0054 0.0584
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0054 0.6647
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0197 0.0917 0.293
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0106 0.0462 0.1406
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0003
Echinococcus granulosus g protein coupled receptor 0.0106 0.0462 0.0462
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0076 0.0422
Brugia malayi ORL1-like opioid receptor 0.0106 0.0462 0.1476
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Brugia malayi SPARC precursor 0.0018 0.0021 0.0067
Schistosoma mansoni hypothetical protein 0.0122 0.0541 0.1646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0151 0.046
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0076 1
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0106 0.0462 0.1476
Mycobacterium leprae Possible oxidoreductase 0.0109 0.0474 0.4884
Loa Loa (eye worm) hypothetical protein 0.0098 0.0422 0.1347
Echinococcus multilocularis sex peptide receptor 0.0106 0.0462 0.0922
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0026 0.0059 0.0638
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Onchocerca volvulus 0.0197 0.0917 0.293
Echinococcus multilocularis agrin 0.0018 0.0021 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0024 0.0051 0.0554
Brugia malayi secreted modular calcium-binding protein 1 0.0018 0.0021 0.0067
Schistosoma mansoni retinoic acid receptor RXR 0.0183 0.0843 0.2566
Echinococcus granulosus alpha 1A adrenergic receptor 0.0106 0.0462 0.0462
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0051 0.0051
Echinococcus multilocularis neuropeptide s receptor 0.1015 0.5014 1
Toxoplasma gondii EGF family domain-containing protein 0.0058 0.0219 0.2391
Schistosoma mansoni hypothetical protein 0.0058 0.0219 0.0667
Echinococcus multilocularis aldo keto reductase 0.0197 0.0917 0.1829
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0364 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0046 0.0204
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1185 0.5215
Plasmodium falciparum aldehyde reductase, putative 0.0109 0.0474 0.5482
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0285 0.0568
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0364 0.1162
Echinococcus granulosus hypothetical protein 0.0197 0.0917 0.0917
Brugia malayi Cytochrome P450 family protein 0.0024 0.0051 0.0162
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0058 0.0219 0.0701
Schistosoma mansoni amine GPCR 0.0106 0.0462 0.1406
Onchocerca volvulus 0.0058 0.0219 0.0701
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0134 0.0427
Schistosoma mansoni amine GPCR 0.0106 0.0462 0.1406
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Leishmania major cytochrome P450 reductase, putative 0.0023 0.0044 0.0477
Onchocerca volvulus 0.0106 0.0462 0.1476
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0076 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0462 0.0922
Echinococcus granulosus fmrfamide receptor 0.0106 0.0462 0.0462
Echinococcus granulosus neuropeptide receptor 0.0106 0.0462 0.0462
Entamoeba histolytica hypothetical protein 0.0035 0.0104 0.0628
Trichomonas vaginalis aldo-keto reductase, putative 0.0109 0.0474 0.2086
Echinococcus multilocularis neurogenic locus notch protein 4 0.0058 0.0219 0.0437
Schistosoma mansoni RAR-like nuclear receptor 0.0087 0.0364 0.1107
Echinococcus multilocularis neuropeptide receptor 0.0106 0.0462 0.0922
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0106 0.0462 0.0922
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0145 0.1582
Onchocerca volvulus 0.0053 0.0195 0.0624
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0024 0.0051 0.0554
Schistosoma mansoni lozenge 0.0056 0.0208 0.0633
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.0059 0.0638
Echinococcus granulosus protein jagged 2 0.0058 0.0219 0.0219
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0018 0.0021 0.0067
Onchocerca volvulus 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus granulosus protein jagged 1 0.0058 0.0219 0.0219
Onchocerca volvulus 0.0027 0.0064 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0451
Onchocerca volvulus Slit protein homolog 0.0058 0.0219 0.0701
Schistosoma mansoni alpha-1 adrenergic receptor 0.0106 0.0462 0.1406
Echinococcus granulosus delta-like protein 1 0.0058 0.0219 0.0219
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Brugia malayi GCC2 and GCC3 family protein 0.0058 0.0219 0.0701
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0147 0.047
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0151 0.0482
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0106 0.0462 0.0462
Onchocerca volvulus Dual oxidase homolog 0.0639 0.3131 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0147 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0145 0.0639
Onchocerca volvulus 0.0106 0.0462 0.1476
Echinococcus granulosus neuropeptides capa receptor 0.0106 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0036 0.0158
Schistosoma mansoni lamin 0.0053 0.0195 0.0594
Echinococcus multilocularis protein jagged 1 0.0058 0.0219 0.0437
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0147 0.047
Loa Loa (eye worm) hypothetical protein 0.0187 0.0864 0.2761
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0205
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0024 0.0051 0.0554
Onchocerca volvulus 0.0053 0.0195 0.0624
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0024 0.0051 0.0554
Loa Loa (eye worm) TK/EGFR protein kinase 0.0145 0.0654 0.2089
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Giardia lamblia Aldose reductase 0.0197 0.0917 0.6792
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Brugia malayi EGF-like domain containing protein 0.0058 0.0219 0.0701
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0134 0.0267
Schistosoma mansoni pol-related 0.0197 0.0917 0.2791
Onchocerca volvulus Protein ultraspiracle homolog 0.0087 0.0364 0.1162
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0024 0.0051 0.0554
Schistosoma mansoni tyrosine kinase 0.0046 0.016 0.0488
Echinococcus granulosus agrin 0.0018 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0475 0.1518
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0054 0.0236
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Brugia malayi sulfakinin receptor protein 0.0106 0.0462 0.1476
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0043 0.0144 0.0461
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0076 0.0881
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) cytochrome P450 0.0024 0.0051 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0338
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0024 0.0051 0.0554
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0106 0.0462 0.0922
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0024 0.0051 0.0554
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0145 0.1089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.135 0.5943
Schistosoma mansoni cytochrome P450 0.0024 0.0051 0.0155
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0195 0.0624
Schistosoma mansoni fatty acid binding protein 0.0033 0.0096 0.0293
Echinococcus multilocularis protein jagged 2 0.0058 0.0219 0.0437
Schistosoma mansoni tyrosine kinase 0.0077 0.0314 0.0956
Loa Loa (eye worm) oxidoreductase 0.0197 0.0917 0.293
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0005 0.0052
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0106 0.0462 0.0462
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0197 0.0917 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0106 0.0462 0.0462
Echinococcus multilocularis ecdysone induced protein 78C 0.0087 0.0364 0.0725
Brugia malayi conserved hypotetical protein 0.0041 0.0134 0.0427
Echinococcus granulosus tm gpcr rhodopsin 0.0106 0.0462 0.0462
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0087 0.0364 0.0725
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0021 0.0067
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0001 0.0002
Onchocerca volvulus 0.0109 0.0474 0.1514
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0052
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Echinococcus multilocularis serotonin receptor 0.0106 0.0462 0.0922
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0224 0.0681
Echinococcus granulosus peptide allatostatin:somatostatin 0.0106 0.0462 0.0462
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0023 0.0044 0.0193
Brugia malayi nuclear hormone receptor 0.0087 0.0364 0.1162
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0147 0.0956
Mycobacterium tuberculosis Conserved protein 0.0043 0.0145 0.1582
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0224 0.2441
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0462 0.0462
Schistosoma mansoni lipoxygenase 0.0229 0.1076 0.3275
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0151 0.0301
Echinococcus multilocularis microtubule associated protein 2 0.067 0.3286 0.6553
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0224 0.0224
Onchocerca volvulus 0.0041 0.0134 0.0427
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0087 0.0364 0.1162
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0002 0.002
Schistosoma mansoni biogenic amine receptor 0.0106 0.0462 0.1406
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0024 0.0051 0.0554
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) FAD binding domain-containing protein 0.0026 0.0059 0.0187
Echinococcus multilocularis neuropeptide receptor A26 0.1015 0.5014 1
Schistosoma mansoni notch 0.0058 0.0219 0.0667
Giardia lamblia Nitric oxide synthase, inducible 0.0023 0.0044 0.0324
Mycobacterium tuberculosis Conserved protein 0.0109 0.0474 0.5167
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0024 0.0051 0.0554
Schistosoma mansoni hypothetical protein 0.0058 0.0219 0.0667
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.1185 0.3785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0147 0.0648
Echinococcus granulosus neuropeptide Y receptor 0.0106 0.0462 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1185 0.5215
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0106 0.0462 0.1406
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0106 0.0462 0.1476
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0158 0.0506
Echinococcus granulosus neuropeptides capa receptor 0.0106 0.0462 0.0462
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0364 0.1162
Onchocerca volvulus 0.0197 0.0917 0.293
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.0366 0.0729
Loa Loa (eye worm) TYRA-2 protein 0.0106 0.0462 0.1476
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0024 0.0051 0.0554
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0147 0.1604
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0057 0.0057
Echinococcus granulosus single minded 2 0.0071 0.0285 0.0285
Schistosoma mansoni gynecophoral canal protein 0.0043 0.0145 0.0442
Echinococcus multilocularis neurogenic locus notch protein 0.0058 0.0219 0.0437
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Brugia malayi jmjC domain containing protein 0.0057 0.0215 0.0686
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0001 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0224 0.0446
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0475 0.1446
Echinococcus granulosus Ankyrin 0.0015 0.0001 0.0001
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0051 0.0554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0151 0.046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.002 0.0064
Echinococcus granulosus allatostatin A receptor 0.0106 0.0462 0.0462
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0134 0.0427
Onchocerca volvulus 0.0106 0.0462 0.1476
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0475 0.2091
Brugia malayi hypoxia-induced factor 1 0.0297 0.1418 0.453
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0753 0.3313
Loa Loa (eye worm) oxidoreductase 0.0197 0.0917 0.293
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0005 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0475 0.2091
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0128 0.0565
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Mycobacterium ulcerans hypothetical protein 0.0043 0.0145 0.1582
Echinococcus multilocularis aldo keto reductase 0.0197 0.0917 0.1829
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0031 0.0338
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0128 0.1399
Giardia lamblia Hypothetical protein 0.0023 0.0044 0.0324
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.002 0.002
Echinococcus granulosus neurogenic locus notch protein 4 0.0058 0.0219 0.0219
Mycobacterium leprae Possible regulatory protein 0.0025 0.0054 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0462 0.0922
Mycobacterium ulcerans glyoxalase GloA 0.0043 0.0145 0.1582
Echinococcus multilocularis fmrfamide receptor 0.0106 0.0462 0.0922
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0106 0.0462 0.1406
Loa Loa (eye worm) runx1 0.0056 0.0208 0.0664
Schistosoma mansoni lipoxygenase 0.016 0.0731 0.2224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0299 0.0596
Echinococcus granulosus g-protein coupled receptor 0.0106 0.0462 0.0462
Echinococcus multilocularis protein jagged 1 0.0058 0.0219 0.0437
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0024 0.0051 0.0554
Echinococcus granulosus biogenic amine 5HT receptor 0.0106 0.0462 0.0462
Schistosoma mansoni biogenic amine (5HT) receptor 0.0106 0.0462 0.1406
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0475 0.5181
Brugia malayi 6-phosphofructokinase 0.0109 0.0475 0.1518
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0106 0.0462 0.0462
Leishmania major cytochrome p450-like protein 0.0024 0.0051 0.0554
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0087 0.0364 0.0725
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0475 0.1446
Toxoplasma gondii glyoxalase I, putative 0.0187 0.0864 0.9426
Echinococcus granulosus epidermal growth factor receptor 0.0145 0.0654 0.0654
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0015
Brugia malayi hypothetical protein 0.0027 0.0064 0.0205
Echinococcus granulosus follistatin 0.0018 0.0021 0.0021
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0109 0.0474 0.5167
Schistosoma mansoni tyrosine kinase 0.0077 0.0314 0.0956
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0054 0.0236
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0076 0.0881
Echinococcus granulosus phd:f box containing protein 0.0015 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0054 0.0236
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0032 0.0348
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Schistosoma mansoni nuclear receptor 0.0041 0.0134 0.0407
Onchocerca volvulus 0.0038 0.012 0.0384
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0158 0.0506
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0064 0.0205
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0197 0.0917 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0023 0.0264
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0036 0.0114
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0002 0.002
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0054 0.0584
Brugia malayi Cadherin domain containing protein 0.0058 0.0219 0.0701
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0005 0.0015
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0475 0.3421
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.016 0.032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0067
Brugia malayi G protein-coupled receptor 0.0106 0.0462 0.1476
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0043 0.0144 0.1575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0147 0.0648
Trypanosoma brucei unspecified product 0.0033 0.0096 0.1049
Schistosoma mansoni opsin-like receptor 0.0106 0.0462 0.1406
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0475 0.1518
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Onchocerca volvulus 0.0106 0.0462 0.1476
Brugia malayi Animal haem peroxidase family protein 0.0639 0.3131 1
Brugia malayi hypothetical protein 0.0035 0.0104 0.0331
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0475 0.3421
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0054 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0005 0.001
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0024 0.0051 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0451
Brugia malayi G-protein coupled receptor 0.0106 0.0462 0.1476
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0134 0.0267
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0106 0.0462 0.1406
Toxoplasma gondii transporter, major facilitator family protein 0.0027 0.0064 0.0699
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0144 0.0461
Brugia malayi ecdysone receptor 0.0041 0.0134 0.0427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0224 0.0681
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.1988 0.6349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0451
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0753 0.3313
Loa Loa (eye worm) hypothetical protein 0.0046 0.0158 0.0506
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Schistosoma mansoni slit 0.0058 0.0219 0.0667
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0197 0.0917 0.293
Echinococcus multilocularis 0.0024 0.0051 0.0101
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0475 0.3421
Schistosoma mansoni thyroid hormone receptor 0.0209 0.0976 0.2971
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0024 0.0051 0.0554
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0024 0.0051 0.0554
Schistosoma mansoni neuropeptide receptor 0.0106 0.0462 0.1406
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0024 0.0051 0.0554
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0475 0.5181
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.012 0.012
Brugia malayi PAS domain containing protein 0.0096 0.041 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0059 0.026
Onchocerca volvulus 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0171
Schistosoma mansoni netrin receptor unc5 0.0014 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0024 0.0051 0.0554
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0134 0.0427
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0024 0.0051 0.0554
Echinococcus granulosus serotonin receptor 0.0106 0.0462 0.0462
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0106 0.0462 0.1406
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0134 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0046 0.0204
Loa Loa (eye worm) neuropeptide F receptor 0.0106 0.0462 0.1476
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0128 0.1399
Echinococcus multilocularis slit 2 protein 0.0058 0.0219 0.0437
Onchocerca volvulus 0.0043 0.0144 0.0461
Echinococcus granulosus neuropeptide s receptor 0.1015 0.5014 0.5014
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0076 0.0422
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0475 0.0475
Brugia malayi steroid hormone receptor 0.0087 0.0364 0.1162
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0147 0.1604
Trichomonas vaginalis sulfite reductase, putative 0.0026 0.0059 0.0258
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0043 0.0145 0.1582
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0106 0.0462 0.1476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0008
Leishmania major aldo-keto reductase-like protein 0.0197 0.0917 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.012 0.024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0109 0.0474 0.5167
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0054 0.0107
Brugia malayi nuclear receptor NHR-88 0.0041 0.0134 0.0427
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0087 0.0364 0.0725
Onchocerca volvulus 0.0468 0.2273 0.726
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0106 0.0462 0.0462
Schistosoma mansoni agrin 0.0018 0.0021 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0051 0.0162
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0144 0.1575
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0106 0.0462 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0401
Loa Loa (eye worm) hypothetical protein 0.0087 0.0364 0.1162
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0158 0.0316
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0054 0.0107
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0753 0.3313
Brugia malayi nuclear receptor RXR 0.0046 0.0158 0.0506
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Schistosoma mansoni hypothetical protein 0.0038 0.012 0.0366
Schistosoma mansoni organic anion transporter 0.0027 0.0064 0.0195
Loa Loa (eye worm) hypothetical protein 0.0039 0.0126 0.0401
Echinococcus granulosus neuropeptide FF receptor 2 0.0106 0.0462 0.0462
Brugia malayi photoreceptor-specific nuclear receptor 0.0087 0.0364 0.1162
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0076 0.0831
Echinococcus granulosus slit 2 protein 0.0058 0.0219 0.0219
Echinococcus multilocularis aldo keto reductase 0.0197 0.0917 0.1829
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0541 0.1079
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0158 0.0506
Schistosoma mansoni microtubule-associated protein tau 0.067 0.3286 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Brugia malayi Animal haem peroxidase family protein 0.0639 0.3131 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.135 0.5943
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0087 0.0364 0.1162
Echinococcus granulosus tachykinin peptides receptor 99D 0.0106 0.0462 0.0462
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0076 0.0564
Schistosoma mansoni aldo-keto reductase 0.0197 0.0917 0.2791
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0797 0.3509
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0024 0.0051 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0008
Brugia malayi Calcium binding EGF domain containing protein 0.0058 0.0219 0.0701
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0051 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0364 0.1162
Echinococcus multilocularis neurogenic locus notch protein 0.0058 0.0219 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0008
Brugia malayi hypothetical protein 0.0098 0.0422 0.1347
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0137 0.0613 0.1223
Onchocerca volvulus 0.0027 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0005
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0054 0.0584
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Schistosoma mansoni tyrosine kinase 0.0078 0.0318 0.0969
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0024 0.0051 0.0554
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0001 0.0003
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0147 0.1604
Echinococcus granulosus neurogenic locus protein delta 0.0058 0.0219 0.0219
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0197 0.0917 1
Brugia malayi Pre-SET motif family protein 0.0411 0.1988 0.6349
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0024 0.0051 0.0554
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0087 0.0364 0.1162
Brugia malayi hypothetical protein 0.0038 0.012 0.0384
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0134 0.0134
Echinococcus multilocularis Protein lozenge 0.0056 0.0208 0.0415
Schistosoma mansoni aldo-keto reductase 0.0197 0.0917 0.2791
Brugia malayi prostaglandin transporter 0.0027 0.0064 0.0205
Echinococcus granulosus tm gpcr rhodopsin 0.0106 0.0462 0.0462
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0087 0.0364 0.1107
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0036 0.0158
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) steroid hormone receptor 0.0087 0.0364 0.1162
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.002 0.0218
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus multilocularis neuropeptides capa receptor 0.0106 0.0462 0.0922
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0027 0.0064 0.0064
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0134 0.0267
Loa Loa (eye worm) oxidoreductase 0.0043 0.0144 0.0461
Onchocerca volvulus 0.0027 0.0064 0.0205
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0026 0.0059 0.0059
Brugia malayi FAD binding domain containing protein 0.0016 0.0009 0.0028
Onchocerca volvulus 0.0058 0.0219 0.0701
Echinococcus granulosus ecdysone induced protein 78C 0.0087 0.0364 0.0364
Onchocerca volvulus 0.0058 0.0219 0.0701
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0104 0.0207
Brugia malayi FAD binding domain containing protein 0.0026 0.0059 0.0187
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0128 0.1399
Brugia malayi hypothetical protein 0.0046 0.0158 0.0506
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0087 0.0364 0.1162
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0106 0.0462 0.1406
Echinococcus multilocularis epidermal growth factor receptor 0.0145 0.0654 0.1304
Brugia malayi follicle stimulating hormone receptor 0.0106 0.0462 0.1476
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0335
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0024 0.0051 0.0554
Brugia malayi cytochrome P450 0.0024 0.0051 0.0162
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0051 0.0162
Echinococcus granulosus peroxidasin 0.0639 0.3131 0.3131
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Echinococcus multilocularis g-protein coupled receptor 0.0106 0.0462 0.0922
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0026 0.0059 0.0638
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.002 0.0148
Echinococcus multilocularis peroxidasin 0.0639 0.3131 0.6244
Brugia malayi hypothetical protein 0.0639 0.3131 1
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0043 0.0145 0.0442
Trypanosoma cruzi aldo/keto reductase, putative 0.0197 0.0917 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0033 0.0096 0.0308
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0134 0.0134
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0002 0.0006
Giardia lamblia GTOR 0.0044 0.0147 0.109
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0318 0.0635
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0106 0.0462 0.1476
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0005 0.0005
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.0059 0.0638
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0087 0.0364 0.0364
Echinococcus multilocularis neurogenic locus protein delta 0.0058 0.0219 0.0437
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0001 0.0001
Echinococcus granulosus Solute carrier organic anion transporter family 0.0027 0.0064 0.0064
Loa Loa (eye worm) blistered cuticle protein 3 0.0639 0.3131 1
Echinococcus granulosus tm gpcr rhodopsin 0.0106 0.0462 0.0462
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Brugia malayi Pre-SET motif family protein 0.0059 0.0224 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0451
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0195 0.0624
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0144 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0009 0.01
Loa Loa (eye worm) oxidoreductase 0.0197 0.0917 0.293
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0151 0.0482
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0054 0.0236
Echinococcus granulosus sex peptide receptor 0.0106 0.0462 0.0462
Brugia malayi notch-like transmembrane receptor 0.0058 0.0219 0.0701
Onchocerca volvulus 0.0445 0.2156 0.6887
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0015
Onchocerca volvulus Neurogenic locus notch homolog 0.0058 0.022 0.0703
Toxoplasma gondii glyoxalase family protein 0.0043 0.0145 0.1582
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0024 0.0051 0.0554
Loa Loa (eye worm) animal heme peroxidase 0.0639 0.3131 1
Onchocerca volvulus 0.0071 0.0285 0.091
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1185 0.5215
Echinococcus multilocularis neural cadherin 0.0058 0.0219 0.0437
Onchocerca volvulus 0.0043 0.0144 0.0461
Onchocerca volvulus 0.0058 0.0219 0.0701
Trichomonas vaginalis aldo-keto reductase, putative 0.0109 0.0474 0.2086
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0215 0.0215
Brugia malayi hypothetical protein 0.0041 0.0134 0.0427
Loa Loa (eye worm) DR-78 0.0041 0.0134 0.0427
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0109 0.0474 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0462 0.0922
Brugia malayi hypothetical protein 0.0445 0.2156 0.6887
Brugia malayi putative neuropeptide receptor NPR1 0.0106 0.0462 0.1476
Onchocerca volvulus 0.0106 0.0462 0.1476
Brugia malayi phosphofructokinase 0.0109 0.0475 0.1518
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0103 0.1119
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0134 0.0427
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0021 0.023
Brugia malayi flavodoxin family protein 0.0026 0.0059 0.0187
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0475 0.5181
Entamoeba histolytica alcohol dehydrogenase, putative 0.0109 0.0474 0.3412
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0134 0.0407
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0051 0.0162
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0005 0.0005
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Brugia malayi Melatonin receptor type 1A 0.0106 0.0462 0.1476
Brugia malayi Delta serrate ligand family protein 0.0058 0.0219 0.0701
Echinococcus granulosus neuropeptide receptor A26 0.1015 0.5014 0.5014
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0187 0.0864 0.2761
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0071 0.0228
Loa Loa (eye worm) animal heme peroxidase 0.0639 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0134 0.0407
Echinococcus multilocularis musashi 0.0053 0.0195 0.039
Brugia malayi G protein-coupled receptor F59B2.13 0.0106 0.0462 0.1476
Schistosoma mansoni cytochrome P450 reductase 0.0026 0.0059 0.0178
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Brugia malayi EGF-like domain containing protein 0.0058 0.0219 0.0701
Trichomonas vaginalis aldo-keto reductase, putative 0.0109 0.0474 0.2086
Echinococcus granulosus lamin dm0 0.0053 0.0195 0.0195
Onchocerca volvulus 0.0043 0.0144 0.0461
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0318 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0462 0.0922
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.012 0.1392
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0215 0.0653
Echinococcus granulosus voltage gated potassium channel subunit 0.0109 0.0474 0.0474
Onchocerca volvulus 0.0018 0.0021 0.0067
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0134 0.0267
Schistosoma mansoni neuropeptide F-like receptor 0.0106 0.0462 0.1406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0087 0.0364 0.1162
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.012 0.024
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0285 0.3105
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0076 0.0831
Brugia malayi hypothetical protein 0.0027 0.0064 0.0205
Brugia malayi lactoylglutathione lyase 0.0187 0.0864 0.2761
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0087 0.0364 0.1162
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0134 0.0427
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0299 0.0299
Schistosoma mansoni notch 0.0058 0.0219 0.0667
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0096 0.1049
Brugia malayi nuclear receptor NHR-67 0.0041 0.0134 0.0427
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0215 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0047 0.0205
Loa Loa (eye worm) agrin synaptic family protein 0.0018 0.0021 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0024 0.0051 0.0554
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0134 0.0134
Schistosoma mansoni amine GPCR 0.0106 0.0462 0.1406
Brugia malayi Serotonin receptor 0.0106 0.0462 0.1476
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0054 0.0236
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0106 0.0462 0.0922
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0197 0.0917 0.293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0087 0.0364 0.1162
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0033 0.0096 0.0308
Loa Loa (eye worm) hypothetical protein 0.0445 0.2156 0.6887
Onchocerca volvulus 0.0639 0.3131 1
Brugia malayi hypothetical protein 0.0322 0.1543 0.493
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0087 0.0364 0.1162
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0462 0.0462
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0109 0.0474 0.5482
Plasmodium falciparum glyoxalase I 0.0043 0.0145 0.1678
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Schistosoma mansoni nuclear receptor 0.0041 0.0134 0.0407
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0159 0.0724 0.7891
Brugia malayi putative neuropeptide receptor 0.0106 0.0462 0.1476
Onchocerca volvulus Chorion peroxidase homolog 0.0639 0.3131 1
Echinococcus granulosus dro:myosuppressin receptor 0.0106 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Trypanosoma cruzi p450 reductase, putative 0.0026 0.0059 0.0638
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0364 0.1162
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0475 0.5181
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus neurogenic locus notch protein 0.0058 0.0219 0.0219
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.016 0.0512
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0475 0.4899
Schistosoma mansoni hypothetical protein 0.0058 0.0219 0.0667
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0335
Brugia malayi Animal haem peroxidase family protein 0.0639 0.3131 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0031 0.0338
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Echinococcus granulosus neuropeptide Y receptor 0.0106 0.0462 0.0462
Echinococcus multilocularis neuropeptides capa receptor 0.0106 0.0462 0.0922
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0027 0.0064 0.0128
Schistosoma mansoni biogenic amine receptor 0.0106 0.0462 0.1406
Echinococcus granulosus fibropellin Ia 0.0058 0.0219 0.0219
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0144 0.0461
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0027 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Brugia malayi EGF-like domain containing protein 0.0058 0.0219 0.0701
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0134 0.0427
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0005 0.0056
Brugia malayi nuclear receptor RXR 0.0041 0.0134 0.0427
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0087 0.0364 0.0364
Onchocerca volvulus 0.007 0.0279 0.0892
Onchocerca volvulus 0.0098 0.0421 0.1345
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.0059 0.0638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0151 0.0151
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0106 0.0462 0.1476
Plasmodium falciparum aldo-keto reductase, putative 0.0109 0.0474 0.5482
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Brugia malayi G-protein coupled receptor 0.0106 0.0462 0.1476
Echinococcus multilocularis dro:myosuppressin receptor 0.0106 0.0462 0.0922
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.002 0.0218
Brugia malayi Protein kinase domain containing protein 0.0014 0.0001 0.0003
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0005 0.0005
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0021 0.023
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0005 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Onchocerca volvulus 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Schistosoma mansoni thyroid hormone receptor 0.0209 0.0976 0.2971
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0384
Brugia malayi Doublecortin family protein 0.0038 0.012 0.0384
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0205
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0018 0.0021 0.0067
Toxoplasma gondii aldose reductase, putative 0.0197 0.0917 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0024 0.0051 0.0554
Leishmania major protein kinase, putative 0.0025 0.0054 0.0584
Schistosoma mansoni fatty acid binding protein 0.0033 0.0096 0.0293
Echinococcus multilocularis dna polymerase kappa 0.004 0.0128 0.0256
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.002 0.0231
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0002 0.002
Echinococcus multilocularis fatty acid binding protein FABP2 0.0033 0.0096 0.0192
Loa Loa (eye worm) hypothetical protein 0.0039 0.0126 0.0401
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0167
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0054 0.0236
Onchocerca volvulus 0.0106 0.0462 0.1476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0058 0.0255
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Echinococcus granulosus g protein coupled receptor 0.0106 0.0462 0.0462
Leishmania major hypothetical protein, conserved 0.0015 0.0005 0.0052
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0043 0.0145 0.1582
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0158 0.0482
Leishmania major p450 reductase, putative 0.0026 0.0059 0.0638
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0106 0.0462 0.1406
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0215 0.0653
Brugia malayi GnHR receptor homolog 0.0106 0.0462 0.1476
Echinococcus granulosus aldo keto reductase 0.0197 0.0917 0.0917
Schistosoma mansoni zinc finger protein 0.0041 0.0134 0.0407
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Mycobacterium ulcerans hypothetical protein 0.0043 0.0145 0.1582
Schistosoma mansoni lamin 0.0053 0.0195 0.0594
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0019 0.0211
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0059 0.026
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0016 0.0009 0.0027
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0005 0.0005
Brugia malayi nuclear receptor NHR-88 0.0087 0.0364 0.1162
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0109 0.0474 0.1514
Schistosoma mansoni ap endonuclease 0.0018 0.002 0.0061
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0106 0.0462 0.0922
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0024 0.0051 0.0554
Loa Loa (eye worm) hypothetical protein 0.0087 0.0364 0.1162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0364 0.1162
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0064 0.0205
Mycobacterium ulcerans hypothetical protein 0.0043 0.0145 0.1582
Loa Loa (eye worm) oxidoreductase 0.0197 0.0917 0.293
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0318 0.0318
Brugia malayi polk-prov protein 0.003 0.008 0.0255
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0026 0.0059 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0115 0.0507
Mycobacterium tuberculosis Conserved protein TB27.3 0.0043 0.0145 0.1582
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0366 0.1113
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0134 0.0427
Schistosoma mansoni neuropeptide f receptor 76f 0.0106 0.0462 0.1406
Schistosoma mansoni hypothetical protein 0.0106 0.0462 0.1406
Schistosoma mansoni tyrosine kinase 0.0078 0.0318 0.0969
Echinococcus granulosus aldo keto reductase 0.0197 0.0917 0.0917
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Echinococcus granulosus RUN 0.0038 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0087 0.0364 0.1162
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0147 0.1604
Schistosoma mansoni steroid hormone receptor ad4bp 0.0087 0.0364 0.1107
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0047 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0151 0.0301
Echinococcus multilocularis RUN 0.0038 0.012 0.024
Brugia malayi Peroxidasin 0.0639 0.3131 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.002 0.0088
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus granulosus methionine synthase reductase 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0445 0.2156 0.6887
Echinococcus multilocularis neurogenic locus protein delta 0.0058 0.0219 0.0437
Echinococcus granulosus dna polymerase kappa 0.004 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Brugia malayi larval opioid receptor 0.0106 0.0462 0.1476
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0106 0.0462 0.1476
Mycobacterium ulcerans short chain dehydrogenase 0.0043 0.0144 0.1575
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) FAD binding domain-containing protein 0.0016 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0475 0.5181
Onchocerca volvulus Peroxidase homolog 0.0639 0.3131 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0106 0.0462 0.0922
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0052
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.135 1
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0005 0.001
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0197 0.0917 0.4036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0087 0.0364 0.1162
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0134 0.0407
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.012 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0451
Loa Loa (eye worm) notch protein 0.0058 0.0219 0.0701
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1185 0.5215
Trypanosoma brucei aldo-keto reductase, putative 0.0197 0.0917 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0054 0.0584
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0021 0.023
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0623 0.6794
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0051 0.0554
Echinococcus multilocularis Ankyrin 0.0015 0.0001 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0128 0.1399
Trypanosoma cruzi aldo-keto reductase 0.0197 0.0917 1
Loa Loa (eye worm) G-protein coupled receptor 0.0106 0.0462 0.1476
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.002 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0106 0.0462 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0147 0.0648
Onchocerca volvulus 0.0106 0.0462 0.1476
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0366 0.1113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0106 0.0462 0.0922
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0024 0.0051 0.0554
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0158 0.0158
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Onchocerca volvulus 0.0197 0.0917 0.293
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0024 0.0051 0.0554
Schistosoma mansoni hypothetical protein 0.0106 0.0462 0.1406
Onchocerca volvulus 0.0106 0.0462 0.1476
Brugia malayi Calcium binding EGF domain containing protein 0.0058 0.0219 0.0701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0462 0.0922
Mycobacterium ulcerans hypothetical protein 0.0043 0.0145 0.1582
Brugia malayi EGF-like domain containing protein 0.0058 0.0219 0.0701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Loa Loa (eye worm) hypothetical protein 0.0039 0.0126 0.0401
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0462 0.0462
Echinococcus granulosus fatty acid binding protein FABP2 0.0033 0.0096 0.0096
Loa Loa (eye worm) RecQ helicase 0.0021 0.0036 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0462 0.0922
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.0059 0.0638
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0064 0.0205
Echinococcus multilocularis fatty acid binding protein FABP2 0.0033 0.0096 0.0192
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0158 0.0506
Onchocerca volvulus 0.0087 0.0364 0.1162
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Echinococcus multilocularis orexin receptor type 2 0.0106 0.0462 0.0922
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0087 0.0364 0.1162
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0103 0.1119
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0224 0.0446
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Schistosoma mansoni biogenic amine receptor 0.0106 0.0462 0.1406
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Onchocerca volvulus 0.0639 0.3131 1
Onchocerca volvulus 0.0106 0.0462 0.1476
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0541 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0046 0.0204
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0087 0.0364 0.1107
Leishmania major prostaglandin f synthase, putative 0.0197 0.0917 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0462 0.0462
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0024 0.0051 0.0554
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0187 0.0864 0.9426
Brugia malayi Animal haem peroxidase family protein 0.0639 0.3131 1
Brugia malayi EGF-like domain containing protein 0.0058 0.0219 0.0701
Loa Loa (eye worm) hypothetical protein 0.0639 0.3131 1
Brugia malayi ecdysteroid receptor 0.0087 0.0364 0.1162
Brugia malayi Cadherin domain containing protein 0.0058 0.0219 0.0701
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0147 0.0956
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0158 0.0482
Onchocerca volvulus 0.0106 0.0462 0.1476
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0005 0.0015
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0197 0.0917 0.4036
Echinococcus granulosus protein jagged 2 0.0058 0.0219 0.0219
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0087 0.0364 0.0364
Onchocerca volvulus 0.0043 0.0144 0.0461
Brugia malayi hypothetical protein 0.0038 0.012 0.0384
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0054 0.0236
Mycobacterium tuberculosis Probable oxidoreductase 0.0197 0.0917 1
Onchocerca volvulus 0.0197 0.0917 0.293
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Echinococcus granulosus insulin receptor 0.0046 0.016 0.016
Brugia malayi Cytochrome P450 family protein 0.0062 0.024 0.0765
Echinococcus granulosus somatostatin receptor 0.0106 0.0462 0.0462
Schistosoma mansoni amine GPCR 0.0106 0.0462 0.1406
Echinococcus granulosus protein jagged 1 0.0058 0.0219 0.0219
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0229 0.1076 0.1076
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0475 0.3421
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.1185 0.3785
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0036 0.0071
Brugia malayi Muscle positioning protein 4 0.0058 0.0219 0.0701
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0051 0.0554
Brugia malayi intermediate filament protein 0.0053 0.0195 0.0624
Loa Loa (eye worm) hypothetical protein 0.0087 0.0364 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0145 0.0639
Loa Loa (eye worm) hypothetical protein 0.0046 0.0158 0.0506
Brugia malayi Serotonin receptor 0.0106 0.0462 0.1476
Brugia malayi tailless protein 0.0041 0.0134 0.0427
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0002 0.002
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0051 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0401
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0087 0.0364 0.1107
Schistosoma mansoni tyrosine kinase 0.0077 0.0314 0.0956
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Echinococcus multilocularis G protein coupled receptor 139 0.0106 0.0462 0.0922
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Leishmania major cytochrome p450-like protein 0.0024 0.0051 0.0554
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0091 0.0993
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.0366 0.0366
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0104 0.0104
Brugia malayi Protein kinase domain containing protein 0.0046 0.016 0.0512
Loa Loa (eye worm) hypothetical protein 0.0052 0.019 0.0608
Trichomonas vaginalis aldo-keto reductase, putative 0.0197 0.0917 0.4036
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0753 0.3313
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0067
Brugia malayi Death domain containing protein 0.0014 0.0001 0.0003
Schistosoma mansoni cell polarity protein 0.0058 0.0219 0.0667
Echinococcus granulosus 7TM GPCR rhodopsin 0.0106 0.0462 0.0462
Giardia lamblia Aldose reductase 0.0197 0.0917 0.6792
Echinococcus multilocularis thyroid hormone receptor alpha 0.0209 0.0976 0.1947
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0018 0.0021 0.0067
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0106 0.0462 0.1476
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0054 0.0584
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Echinococcus granulosus G protein coupled receptor 139 0.0106 0.0462 0.0462
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0106 0.0462 0.1406
Giardia lamblia High cysteine protein 0.0058 0.0219 0.1624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0087 0.0364 0.1162
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0134 0.0134
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0197 0.0917 0.1829
Onchocerca volvulus 0.0027 0.0064 0.0205
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.135 1
Schistosoma mansoni notch 0.0058 0.022 0.0669
Schistosoma mansoni hypothetical protein 0.0058 0.0219 0.0667
Schistosoma mansoni neuropeptide receptor 0.0106 0.0462 0.1406
Onchocerca volvulus 0.0025 0.0054 0.0171
Schistosoma mansoni hypothetical protein 0.0058 0.0219 0.0667
Brugia malayi AKH receptor 0.0106 0.0462 0.1476
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0087 0.0364 0.1107
Mycobacterium leprae Conserved hypothetical protein 0.0088 0.0372 0.3705
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0015
Schistosoma mansoni tyrosine kinase 0.0145 0.0654 0.1991
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0054 0.0584
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0147 0.0293
Trichomonas vaginalis aldo/keto reductase, putative 0.0197 0.0917 0.4036
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0147 0.0147
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0024 0.0051 0.0554
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0106 0.0462 0.1476
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0076 0.0881
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0087 0.0364 0.1107
Schistosoma mansoni hypothetical protein 0.0058 0.0219 0.0667
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Schistosoma mansoni laminin gamma-3 chain 0.0058 0.0219 0.0667
Echinococcus multilocularis g protein coupled receptor 0.0106 0.0462 0.0922
Echinococcus multilocularis neuropeptide Y receptor 0.0106 0.0462 0.0922
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0015
Brugia malayi Blistered cuticle protein 3 0.0639 0.3131 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0197 0.0917 0.293
Schistosoma mansoni organic anion transporter 0.0027 0.0064 0.0195
Echinococcus granulosus notch 0.0058 0.0219 0.0219
Leishmania major cytochrome p450-like protein 0.0024 0.0051 0.0554
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0753 0.3313
Toxoplasma gondii aldo-keto reductase 0.0109 0.0474 0.5167
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Entamoeba histolytica hypothetical protein 0.0035 0.0104 0.0628
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0024 0.0051 0.0554
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.002 0.004
Brugia malayi Furin-like cysteine rich region family protein 0.0145 0.0654 0.2089
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0052
Schistosoma mansoni opsin-like receptor 0.0106 0.0462 0.1406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Echinococcus multilocularis rhodopsin orphan GPCR 0.0106 0.0462 0.0922
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0076 0.0881
Brugia malayi RE15519p 0.0106 0.0462 0.1476
Plasmodium vivax glyoxalase I, putative 0.0043 0.0145 0.1678
Echinococcus multilocularis 0.0045 0.0153 0.0305
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1185 0.5215
Loa Loa (eye worm) hypothetical protein 0.0087 0.0364 0.1162
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0058 0.0219 0.0667
Echinococcus granulosus bloom syndrome protein 0.0021 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0401
Echinococcus multilocularis somatostatin receptor 0.0106 0.0462 0.0922
Onchocerca volvulus Peroxidasin homolog 0.0639 0.3131 1
Onchocerca volvulus 0.0106 0.0462 0.1476
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.008 0.0869
Echinococcus granulosus neuropeptide receptor 0.0106 0.0462 0.0462
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0134 0.0427
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0076 0.0831
Echinococcus multilocularis voltage gated potassium channel subunit 0.0109 0.0474 0.0945
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0024 0.0051 0.0554
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0475 0.1518
Onchocerca volvulus 0.0106 0.0462 0.1476
Loa Loa (eye worm) melatonin receptor type 1A 0.0106 0.0462 0.1476
Plasmodium falciparum glyoxalase I 0.0187 0.0864 1
Entamoeba histolytica aldose reductase, putative 0.0197 0.0917 0.6744
Brugia malayi Uncoordinated protein 44 0.0014 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0474 0.2086
Schistosoma mansoni biogenic amine (5HT) receptor 0.0106 0.0462 0.1406
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0197 0.0917 0.4036
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0015
Loa Loa (eye worm) animal heme peroxidase 0.0639 0.3131 1
Schistosoma mansoni hypothetical protein 0.0058 0.0219 0.0667
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0462 0.0462
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0134 0.0267
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0134 0.0407
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0753 0.3313
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0109 0.0474 0.1514
Schistosoma mansoni growth hormone secretagogue receptor 0.0106 0.0462 0.1406
Brugia malayi hypothetical protein 0.0041 0.0134 0.0427
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0002 0.0006
Brugia malayi jmjC domain containing protein 0.0057 0.0215 0.0686
Brugia malayi hypothetical protein 0.0046 0.0158 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0091 0.0401
Brugia malayi Tachykinin-like peptides receptor 99D 0.0106 0.0462 0.1476
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0213 0.0213
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0229 0.1076 0.2146
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0024 0.0051 0.0554
Echinococcus multilocularis G-protein coupled receptor, putative 0.0106 0.0462 0.0922
Trichomonas vaginalis aldo/keto reductase, putative 0.0197 0.0917 0.4036
Loa Loa (eye worm) G-protein coupled receptor 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0053 0.0195 0.0624
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0106 0.0462 0.1406
Echinococcus multilocularis fmrfamide receptor 0.0106 0.0462 0.0922
Loa Loa (eye worm) hypothetical protein 0.0059 0.0224 0.0715
Schistosoma mansoni hypothetical protein 0.0035 0.0104 0.0315
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0026 0.0059 0.0638
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0197 0.0917 0.0917
Brugia malayi Dopamine receptor protein 1 0.0106 0.0462 0.1476
Mycobacterium ulcerans epoxide hydrolase EphA 0.0159 0.0724 0.7891
Echinococcus multilocularis fibropellin Ia 0.0058 0.0219 0.0437
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0205
Brugia malayi hypothetical protein 0.0043 0.0144 0.0461
Mycobacterium ulcerans oxidoreductase 0.0197 0.0917 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0128 0.1399
Echinococcus granulosus neural cadherin 0.0058 0.0219 0.0219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.135 0.5943
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0009 0.01
Schistosoma mansoni notch 0.0058 0.0219 0.0667
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0285 0.091
Loa Loa (eye worm) hypothetical protein 0.003 0.008 0.0255
Loa Loa (eye worm) hypothetical protein 0.0087 0.0364 0.1162
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0087 0.0364 0.0725
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.002 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0151 0.046
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0054 0.0236
Plasmodium falciparum nitric oxide synthase, putative 0.0026 0.0059 0.0677
Trichomonas vaginalis set domain proteins, putative 0.0468 0.2272 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0013 0.004
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0027 0.0064 0.0128
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.024 0.0765
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.016 0.016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.0279 0.085
Echinococcus granulosus g protein coupled receptor 0.0106 0.0462 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0753 0.3313
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.135 0.5943
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0001 0.0003
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0026 0.0059 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0047 0.0205
Schistosoma mansoni peroxidasin 0.0639 0.3131 0.9528
Onchocerca volvulus 0.0197 0.0917 0.293
Echinococcus multilocularis neuropeptide FF receptor 2 0.0106 0.0462 0.0922
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0071 0.0228
Schistosoma mansoni neuropeptide F-like receptor 0.0106 0.0462 0.1406
Echinococcus multilocularis expressed protein 0.0018 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0009 0.01
Plasmodium vivax SET domain protein, putative 0.0059 0.0224 0.259
Schistosoma mansoni neuropeptide receptor 0.0106 0.0462 0.1406
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0106 0.0462 0.1406
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.012 0.1392
Schistosoma mansoni myosin xvIII 0.0106 0.0462 0.1406
Echinococcus multilocularis g protein coupled receptor 0.0106 0.0462 0.0922
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Schistosoma mansoni hypothetical protein 0.0106 0.0462 0.1406
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0064 0.0205
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0364 0.1107
Loa Loa (eye worm) hypoxia-induced factor 1 0.0297 0.1418 0.453
Trichomonas vaginalis aldo/keto reductase, putative 0.0197 0.0917 0.4036
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0021 0.023
Onchocerca volvulus 0.0106 0.0462 0.1476
Schistosoma mansoni peroxidasin 0.0639 0.3131 0.9528
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0167
Toxoplasma gondii exonuclease III APE 0.0018 0.002 0.0218
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.0701
Brugia malayi Steroid receptor seven-up type 2 0.0087 0.0364 0.1162
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0215 0.0428
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0106 0.0462 0.1406
Echinococcus granulosus rhodopsin orphan GPCR 0.0106 0.0462 0.0462
Schistosoma mansoni neuropeptide receptor 0.0106 0.0462 0.1406
Echinococcus granulosus death domain containing protein 0.0014 0.0001 0.0001
Toxoplasma gondii protease inhibitor PI2 0.0018 0.0021 0.023
Trypanosoma brucei prostaglandin f synthase 0.0197 0.0917 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0024 0.0051 0.0554
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0015
Echinococcus multilocularis aldo keto reductase 0.0197 0.0917 0.1829
Echinococcus multilocularis methionine synthase reductase 0.0016 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0098 0.0421 0.1345
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Brugia malayi EGF-like domain containing protein 0.0058 0.0219 0.0701
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0002 0.0004
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0054 0.0054
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.002 0.0218
Echinococcus granulosus 7tm_1 domain containing protein 0.0106 0.0462 0.0462
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0076 0.0335
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0015
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0054 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0075 0.0331
Brugia malayi hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0039 0.0126 0.0401
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Schistosoma mansoni follistatin 0.0018 0.0021 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0224 0.0681
Loa Loa (eye worm) Notch2 0.0058 0.0219 0.0701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0008
Onchocerca volvulus Neuropeptide F receptor homolog 0.0106 0.0462 0.1476
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.002 0.0088
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0147 0.1604
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Onchocerca volvulus 0.0058 0.0219 0.0701
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0087 0.0364 0.1162
Loa Loa (eye worm) hypothetical protein 0.0322 0.1543 0.493
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0128 0.0565
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.002 0.0218
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0106 0.0462 0.1476
Brugia malayi EGF-like domain containing protein 0.0058 0.0219 0.0701
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.012 0.024
Schistosoma mansoni septate junction protein 0.0058 0.0219 0.0667
Onchocerca volvulus 0.0027 0.0064 0.0205
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0018 0.0021 0.0067
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0026 0.0059 0.0638
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0205
Schistosoma mansoni rab6-interacting 0.0038 0.012 0.0366
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0797 0.3509
Echinococcus granulosus lamin 0.0053 0.0195 0.0195
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0128 0.1399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0087 0.0364 0.1162
Echinococcus multilocularis insulin receptor 0.0046 0.016 0.032
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0106 0.0462 0.0922
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0134 0.0134
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0623 0.6794
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0087 0.0364 0.0364
Echinococcus granulosus neurogenic locus notch protein 0.0058 0.0219 0.0219
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0057 0.0114
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0187 0.0864 0.9426
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0103 0.1119
Echinococcus granulosus hypothetical protein 0.0106 0.0462 0.0462
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0087 0.0364 0.1107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.135 0.5943
Echinococcus multilocularis notch 0.0058 0.0219 0.0437
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0024 0.0051 0.0554
Loa Loa (eye worm) hypothetical protein 0.0046 0.0158 0.0506
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0005 0.0015
Brugia malayi 6-phosphofructokinase 0.0109 0.0476 0.152
Loa Loa (eye worm) neuropeptide F receptor 0.0106 0.0462 0.1476
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0427
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0134 0.0427
Onchocerca volvulus Bile acid receptor homolog 0.0087 0.0364 0.1162
Echinococcus granulosus orexin receptor type 2 0.0106 0.0462 0.0462
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0005 0.001
Plasmodium vivax glyoxalase I, putative 0.0187 0.0864 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0106 0.0462 0.0922
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.135 0.5943
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0128 0.1399

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.442 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.509 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
IFI promiscuity index = 0.02299 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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