Detailed information for compound 866670

Basic information

Technical information
  • TDR Targets ID: 866670
  • Name: N-[(2-methoxyphenyl)methyl]-2-(2-methylpropyl )-1-oxo-3-thiophen-2-yl-3,4-dihydroisoquinoli ne-4-carboxamide
  • MW: 448.577 | Formula: C26H28N2O3S
  • H donors: 1 H acceptors: 2 LogP: 4.44 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CNC(=O)C1c2ccccc2C(=O)N(C1c1cccs1)CC(C)C
  • InChi: 1S/C26H28N2O3S/c1-17(2)16-28-24(22-13-8-14-32-22)23(19-10-5-6-11-20(19)26(28)30)25(29)27-15-18-9-4-7-12-21(18)31-3/h4-14,17,23-24H,15-16H2,1-3H3,(H,27,29)
  • InChiKey: DRTXUXSSVIINLL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-isobutyl-N-[(2-methoxyphenyl)methyl]-1-oxo-3-(2-thienyl)-3,4-dihydroisoquinoline-4-carboxamide
  • 2-isobutyl-1-keto-N-(2-methoxybenzyl)-3-(2-thienyl)-3,4-dihydroisoquinoline-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus active breakpoint cluster region 0.0121 0.207 0.9565
Echinococcus granulosus synaptotagmin 2 0.0121 0.207 0.9565
Loa Loa (eye worm) sugar transporter 0.0126 0.216 1
Leishmania major hypothetical protein, conserved 0.0121 0.207 1
Echinococcus multilocularis copine 9 0.0121 0.207 0.9565
Trypanosoma brucei glucose transporter, putative 0.0039 0.0493 0.2062
Schistosoma mansoni mctp-related 0.0121 0.207 0.9565
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0121 0.207 1
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Onchocerca volvulus 0.0121 0.207 1
Onchocerca volvulus 0.0121 0.207 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trichomonas vaginalis synaptotagmin, putative 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0038 0.0469 0.2017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0493 0.1973
Toxoplasma gondii Sma protein 0.0121 0.207 0.3062
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0283 0.0961
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0038 0.0469 0.2017
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0121 0.207 0.2003
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0121 0.207 0.9565
Schistosoma mansoni protein kinase C 0.0121 0.207 0.9565
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0121 0.207 1
Brugia malayi Copine VIII 0.0121 0.207 0.9565
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0484 0.2088
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0121 0.207 0.9565
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0121 0.207 0.9565
Trichomonas vaginalis synaptotagmin, putative 0.0121 0.207 0.9565
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0121 0.207 0.9565
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0438 0.1707
Trypanosoma brucei predicted C2 domain protein 0.0121 0.207 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Toxoplasma gondii Elicitor-responsive protein, putative 0.0121 0.207 0.3062
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Schistosoma mansoni synaptotagmin 0.0121 0.207 0.9565
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0283 0.0961
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0484 0.0617
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0283 0.1005
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0484 0.1927
Entamoeba histolytica protein kinase, putative 0.0039 0.0484 0.0794
Entamoeba histolytica hypothetical protein, conserved 0.0121 0.207 0.7072
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0484 0.0404
Trypanosoma brucei C2 domain containing protein, putative 0.0121 0.207 1
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0283 0.0961
Echinococcus multilocularis synaptotagmin 0.0121 0.207 0.9565
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0484 0.1927
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0493 0.2062
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.216 1
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Echinococcus granulosus synaptotagmin 0.0121 0.207 0.9565
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0121 0.207 0.7072
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Loa Loa (eye worm) synaptotagmin-1 0.0121 0.207 0.9574
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0121 0.207 0.9574
Onchocerca volvulus 0.0121 0.207 1
Trypanosoma brucei hypothetical protein, conserved 0.0121 0.207 1
Echinococcus granulosus synaptotagmin 15 0.0121 0.207 0.9565
Echinococcus multilocularis synaptotagmin 15 0.0121 0.207 0.9565
Loa Loa (eye worm) Nedd4-PD 0.0121 0.207 0.9574
Schistosoma mansoni hypothetical protein 0.0121 0.207 0.9565
Loa Loa (eye worm) sugar transporter 0.0018 0.0084 0.0199
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.207 1
Trypanosoma brucei C2 domain containing protein, putative 0.0121 0.207 1
Treponema pallidum prolyl-tRNA synthetase 0.0013 0 0.5
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0121 0.207 1
Trypanosoma cruzi C2 domain containing protein, putative 0.0121 0.207 1
Loa Loa (eye worm) C2 domain-containing protein 0.0121 0.207 0.9574
Trichomonas vaginalis synaptotagmin, putative 0.0121 0.207 0.9565
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Brugia malayi phospholipase C homolog 0.0121 0.207 0.9565
Schistosoma mansoni hypothetical protein 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0154 0.0352
Trypanosoma brucei hypothetical protein, conserved 0.0121 0.207 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trypanosoma brucei cAMP binding protein, putative 0.0121 0.207 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0084 0.2954
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0493 0.2062
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.2116 0.9788
Toxoplasma gondii hypothetical protein 0.0121 0.207 0.3062
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0121 0.207 1
Echinococcus multilocularis synaptotagmin 0.0121 0.207 0.9565
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0493 0.2062
Toxoplasma gondii C2 domain-containing protein 0.0121 0.207 0.3062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Schistosoma mansoni synaptotagmin 0.0121 0.207 0.9565
Leishmania major phospholipase c-like protein 0.0121 0.207 1
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0121 0.207 0.9565
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Trichomonas vaginalis vab10 spectraplakin, putative 0.0121 0.207 0.9565
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Echinococcus multilocularis synaptotagmin protein 4 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Schistosoma mansoni glut4 vesicle protein-related 0.0121 0.207 0.9565
Brugia malayi Variant SH3 domain containing protein 0.0121 0.207 0.9565
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0283 1
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0493 0.1973
Trypanosoma cruzi cAMP binding protein, putative 0.0121 0.207 1
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Trypanosoma brucei glucose transporter 2A 0.0039 0.0493 0.2062
Trichomonas vaginalis copine, putative 0.0121 0.207 0.9565
Schistosoma mansoni rho gtpase activating protein 0.0121 0.207 0.9565
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0493 0.2062
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.216 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0469 0.1855
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0121 0.207 0.9565
Echinococcus granulosus General substrate transporter 0.0108 0.1821 0.8364
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0484 0.1927
Echinococcus granulosus unc 13 munc13 0.0121 0.207 0.9565
Echinococcus granulosus copine 9 0.0121 0.207 0.9565
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0121 0.207 0.9574
Echinococcus granulosus protein kinase C gamma type 0.0124 0.2116 0.9788
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0589 0.2544
Schistosoma mansoni fer-1-related 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0121 0.207 0.9565
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0283 0.3046
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0484 0.0404
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0121 0.207 0.9565
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.2116 0.9788
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Mycobacterium ulcerans sugar transporter 0.0018 0.0084 0.2954
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Echinococcus granulosus synaptotagmin 0.0121 0.207 0.9565
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0283 0.0961
Plasmodium falciparum double C2-like domain-containing protein 0.0121 0.207 0.2003
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0493 0.1973
Entamoeba histolytica hypothetical protein, conserved 0.0121 0.207 0.7072
Entamoeba histolytica hypothetical protein 0.0121 0.207 0.7072
Entamoeba histolytica hypothetical protein 0.0121 0.207 0.7072
Trypanosoma brucei glucose transporter, putative 0.0039 0.0493 0.2062
Entamoeba histolytica hypothetical protein 0.0121 0.207 0.7072
Leishmania major glucose transporter, lmgt3 0.0039 0.0493 0.2062
Entamoeba histolytica protein kinase, putative 0.016 0.281 1
Trichomonas vaginalis synaptotagmin, putative 0.0121 0.207 0.9565
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.207 1
Leishmania major hypothetical protein, conserved 0.0121 0.207 1
Trichomonas vaginalis synaptotagmin, putative 0.0121 0.207 0.9565
Trypanosoma brucei glucose transporter, putative 0.0039 0.0493 0.2062
Brugia malayi Synapse defective protein 1 0.0121 0.207 0.9565
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0121 0.207 0.9565
Entamoeba histolytica C2 domain protein, putative 0.0121 0.207 0.7072
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0469 0.1855
Leishmania major c2 domain protein, putative 0.0121 0.207 1
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Trypanosoma brucei glucose transporter 1E 0.0039 0.0493 0.2062
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Schistosoma mansoni synaptotagmin-like protein 0.0121 0.207 0.9565
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0484 0.0404
Plasmodium falciparum ferlin, putative 0.0121 0.207 0.2003
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.216 1
Schistosoma mansoni hypothetical protein 0.0121 0.207 0.9565
Schistosoma mansoni otoferlin 0.0121 0.207 0.9565
Schistosoma mansoni synaptotagmin 12 0.0121 0.207 0.9565
Schistosoma mansoni glucose transport protein 0.0126 0.216 1
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0121 0.207 0.9565
Echinococcus multilocularis unc 13 (munc13) 0.0121 0.207 0.9565
Loa Loa (eye worm) C2 domain-containing protein 0.0121 0.207 0.9574
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0121 0.207 1
Entamoeba histolytica hypothetical protein 0.0121 0.207 0.7072
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0283 0.5182
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0484 0.1927
Trypanosoma brucei glucose transporter, putative 0.0039 0.0493 0.2062
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0121 0.207 0.9565
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0121 0.207 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0484 0.0404
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0469 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0084 0.0199
Echinococcus multilocularis intersectin 2 0.0121 0.207 0.9565
Schistosoma mansoni glucose transport protein 0.0126 0.216 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Leishmania major hypothetical protein, conserved 0.0121 0.207 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0493 0.1973
Echinococcus granulosus extended synaptotagmin 2 0.0121 0.207 0.9565
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0121 0.207 0.9565
Trypanosoma brucei glucose transporter, putative 0.0039 0.0493 0.2062
Brugia malayi LD23056p 0.0121 0.207 0.9565
Echinococcus granulosus otoferlin 0.0121 0.207 0.9565
Echinococcus multilocularis extended synaptotagmin 2 0.0121 0.207 0.9565
Echinococcus multilocularis synaptotagmin 0.0121 0.207 0.9565
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0121 0.207 0.9565
Brugia malayi Synaptotagmin protein 3 0.0121 0.207 0.9565
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0121 0.207 0.9565
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.216 0.3201
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Schistosoma mansoni unc-13 (munc13) 0.0121 0.207 0.9565
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0469 0.0734
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0283 0.0961
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Schistosoma mansoni rabphilin-3a 0.0121 0.207 0.9565
Loa Loa (eye worm) copine family protein 0.0121 0.207 0.9574
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0031 0.0333 0.1375
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0121 0.207 0.9565
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0084 0.0199
Schistosoma mansoni synaptotagmin 0.0121 0.207 0.9565
Plasmodium falciparum protein kinase 7 0.0357 0.6571 0.6542
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.216 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0121 0.207 0.9565
Trypanosoma cruzi synaptotagmin, putative 0.0121 0.207 1
Echinococcus multilocularis General substrate transporter 0.0108 0.1821 0.8364
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0589 0.2544
Trypanosoma brucei predicted C2 domain protein 0.0121 0.207 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0084 0.2954
Echinococcus multilocularis serine threonine protein kinase 0.0124 0.2116 0.9788
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.207 1
Loa Loa (eye worm) C2 domain-containing protein 0.0121 0.207 0.9574
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Echinococcus granulosus neural cell expressed developmentally 0.0121 0.207 0.9565
Brugia malayi Sugar transporter family protein 0.0126 0.216 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.216 1
Schistosoma mansoni synaptotagmin 12 0.0121 0.207 0.9565
Brugia malayi calpain 5 0.0121 0.207 0.9565
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0283 0.1005
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Brugia malayi WW domain containing protein 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trypanosoma cruzi hexose transporter 0.0039 0.0493 0.2062
Brugia malayi Protein kinase c protein 2 0.0124 0.2116 0.9788
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.207 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0484 0.1927
Entamoeba histolytica calcium-binding protein, putative 0.0121 0.207 0.7072
Plasmodium vivax hexose transporter 0.0126 0.216 0.2094
Trichomonas vaginalis copine, putative 0.0121 0.207 0.9565
Leishmania major protein kinase, putative 0.0039 0.0484 0.2014
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0121 0.207 0.9565
Entamoeba histolytica DENN domain protein 0.0121 0.207 0.7072
Schistosoma mansoni hypothetical protein 0.0121 0.207 0.9565
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0493 0.1973
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0121 0.207 1
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0084 0.2954
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trichomonas vaginalis annexin VII, putative 0.0121 0.207 0.9565
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0469 0.1855
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0438 0.1707
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0283 0.0201
Echinococcus multilocularis protein piccolo 0.0121 0.207 0.9565
Trypanosoma brucei synaptotagmin, putative 0.0121 0.207 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0484 0.0617
Trichomonas vaginalis ion channel nompc, putative 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Onchocerca volvulus 0.0121 0.207 1
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Trichomonas vaginalis copine, putative 0.0121 0.207 0.9565
Schistosoma mansoni synaptotagmin 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0484 0.0404
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0484 0.1927
Schistosoma mansoni protein kinase 0.0039 0.0484 0.1927
Echinococcus multilocularis copine 9 0.0121 0.207 0.9565
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0283 0.0961
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Loa Loa (eye worm) C2 domain-containing protein 0.0121 0.207 0.9574
Leishmania major copine i-like protein 0.0121 0.207 1
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0589 0.051
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0121 0.207 0.9565
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0484 0.1927
Loa Loa (eye worm) C2 domain-containing protein 0.0121 0.207 0.9574
Echinococcus granulosus UNCoordinated family member unc 13 0.0121 0.207 0.9565
Echinococcus granulosus protein kinase c epsilon type 0.0124 0.2116 0.9788
Leishmania major c2 domain protein, putative 0.0121 0.207 1
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.207 1
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Plasmodium vivax double C2-like domain-containing protein, putative 0.0121 0.207 0.2003
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Echinococcus granulosus synaptotagmin 0.0121 0.207 0.9565
Trichomonas vaginalis copine, putative 0.0121 0.207 0.9565
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0202 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0469 0.1855
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0124 0.2116 0.9792
Loa Loa (eye worm) hypothetical protein 0.0028 0.0283 0.1141
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0469 0.1855
Schistosoma mansoni hypothetical protein 0.0121 0.207 0.9565
Entamoeba histolytica hypothetical protein 0.0121 0.207 0.7072
Schistosoma mansoni protein kinase 0.0039 0.0484 0.1927
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0121 0.207 0.9565
Echinococcus granulosus synaptotagmin protein 4 0.0121 0.207 0.9565
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0121 0.207 0.9565
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Trichomonas vaginalis synaptotagmin, putative 0.0121 0.207 0.9565
Leishmania major hypothetical protein, conserved 0.0121 0.207 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0484 0.1927
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0484 0.1927
Echinococcus granulosus synaptotagmin 0.0121 0.207 0.9565
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0589 0.0779
Echinococcus granulosus calpain 5 0.0121 0.207 0.9565
Plasmodium falciparum ferlin, putative 0.0121 0.207 0.2003
Echinococcus granulosus myoferlin 0.0121 0.207 0.9565
Echinococcus multilocularis synaptotagmin 0.0121 0.207 0.9565
Onchocerca volvulus 0.0121 0.207 1
Schistosoma mansoni copine 0.0121 0.207 0.9565
Schistosoma mansoni hypothetical protein 0.0126 0.216 1
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0121 0.207 0.9565
Schistosoma mansoni synaptotagmin 0.0121 0.207 0.9565
Trichomonas vaginalis copine, putative 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0283 1
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0121 0.207 1
Echinococcus multilocularis active breakpoint cluster region 0.0121 0.207 0.9565
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0039 0.0484 0.2088
Toxoplasma gondii hypothetical protein 0.0121 0.207 0.3062
Leishmania major hypothetical protein, conserved 0.0121 0.207 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0484 0.1927
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0121 0.207 1
Schistosoma mansoni protein kinase 0.0039 0.0484 0.1927
Echinococcus multilocularis 0.0121 0.207 0.9565
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0217 0.0641
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Brugia malayi Synaptotagmin I 0.0121 0.207 0.9565
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.3649 0.5495
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0493 0.2062
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Plasmodium vivax ferlin, putative 0.0121 0.207 0.2003
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0484 0.2088
Plasmodium vivax hypothetical protein, conserved 0.0121 0.207 0.2003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.216 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0493 0.2062
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0589 0.051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0121 0.207 0.9565
Entamoeba histolytica hypothetical protein 0.0121 0.207 0.7072
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0484 0.0617
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0084 0.5
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0121 0.207 0.9565
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 1 1
Echinococcus multilocularis protein kinase c epsilon type 0.0124 0.2116 0.9788
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Leishmania major hypothetical protein, conserved 0.0121 0.207 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0469 0.1855
Schistosoma mansoni unc-13 (munc13) 0.0121 0.207 0.9565
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.216 1
Plasmodium vivax ferlin, putative 0.0121 0.207 0.2003
Trypanosoma brucei C2 domain containing protein, putative 0.0121 0.207 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0493 0.1973
Plasmodium falciparum hexose transporter 0.0126 0.216 0.2094
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0484 0.0404
Trichomonas vaginalis synaptotagmin, putative 0.0121 0.207 0.9565
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0283 0.1005
Echinococcus multilocularis neural cell expressed, developmentally 0.0121 0.207 0.9565
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0484 0.0404
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0493 0.2062
Echinococcus granulosus protein piccolo 0.0121 0.207 0.9565
Entamoeba histolytica protein kinase, putative 0.0124 0.2116 0.7254
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.207 1
Brugia malayi C2 domain containing protein 0.0121 0.207 0.9565
Echinococcus multilocularis synaptotagmin 0.0121 0.207 0.9565
Echinococcus multilocularis synaptotagmin 2 0.0121 0.207 0.9565
Leishmania major glucose transporter, lmgt2 0.0039 0.0493 0.2062
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0469 1
Trypanosoma brucei C2 domain containing protein, putative 0.0121 0.207 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0124 0.2116 0.9788
Trichomonas vaginalis Proline-rich protein, putative 0.0121 0.207 0.9565
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0121 0.207 0.9574
Brugia malayi protein kinase C II. 0.0124 0.2116 0.9788
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0121 0.207 0.9565
Leishmania major glucose transporter, lmgt1 0.0039 0.0493 0.2062
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.207 1
Schistosoma mansoni glucose transport protein 0.0126 0.216 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0589 0.2544
Onchocerca volvulus 0.0121 0.207 1
Trypanosoma cruzi synaptotagmin, putative 0.0121 0.207 1
Brugia malayi NEDD4.2 0.0121 0.207 0.9565
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0121 0.207 0.9565
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0121 0.207 0.9565
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0121 0.207 0.3062
Brugia malayi Copine family protein 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0121 0.207 0.9565
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0493 0.1973
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.3649 0.3595
Schistosoma mansoni Mername-AA248 (C02 family) 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Echinococcus granulosus copine 9 0.0121 0.207 0.9565
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Loa Loa (eye worm) C2 domain-containing protein 0.0121 0.207 0.9574
Trypanosoma brucei predicted C2 domain protein 0.0121 0.207 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0589 0.2544
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0121 0.207 0.9565
Brugia malayi Synapse defective protein 1 0.0121 0.207 0.9565
Trypanosoma brucei glucose transporter, putative 0.0039 0.0493 0.2062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Echinococcus granulosus synaptotagmin 0.0121 0.207 0.9565
Schistosoma mansoni synaptotagmin 0.0121 0.207 0.9565
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0202 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0124 0.2116 0.9788
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0283 0.0308
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Toxoplasma gondii ferlin family protein 0.0121 0.207 0.3062
Onchocerca volvulus 0.0121 0.207 1
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0283 0.0201
Leishmania major hypothetical protein, conserved 0.0121 0.207 1
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0121 0.207 0.9565
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0589 0.2544
Toxoplasma gondii protein kinase, putative 0.0357 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Entamoeba histolytica C2 domain containing protein 0.0121 0.207 0.7072
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0124 0.2116 0.9792
Echinococcus granulosus intersectin 2 0.0121 0.207 0.9565
Schistosoma mansoni unc-13 (munc13) 0.0121 0.207 0.9565
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.3649 0.3595
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0121 0.207 0.9565
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.2116 0.9788
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0121 0.207 0.9565
Toxoplasma gondii hypothetical protein 0.0121 0.207 0.3062
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0121 0.207 0.9565
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.216 1
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.207 0.9565
Echinococcus multilocularis myoferlin 0.0121 0.207 0.9565
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0121 0.207 0.9565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0199
Loa Loa (eye worm) hypothetical protein 0.0121 0.207 0.9574
Echinococcus multilocularis calpain 5 0.0121 0.207 0.9565
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0484 0.1927
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0469 0.1855
Echinococcus granulosus Immunoglobulin E set 0.0121 0.207 0.9565
Onchocerca volvulus Putative cc2d1b protein 0.0121 0.207 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0493 0.2062
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.216 1
Onchocerca volvulus 0.0121 0.207 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0484 0.2014
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0484 0.0404
Leishmania major hypothetical protein, conserved 0.0121 0.207 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0493 0.2062
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0121 0.207 0.9565
Brugia malayi Cam kinase protein 1 0.0039 0.0484 0.1927

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 3.1587 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 3.16 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 3.6965 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 3.7 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
Growth Inhibition (functional) = 12.474 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 1143 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) = 19.6805858612061 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 > 32 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
Inhibition (functional) = -15.8814808342219 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -15 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = -12.028697398066015 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -12.028697398066 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 8.382190898402 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 9.76 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 15.7 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 17 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 58.9405678412987 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 58.94056784129873 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 97 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
Percent growth inhibition (functional) = 95.3 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Percent growth inhibition (functional) = 113.3 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428
Ratio (functional) = 1.0377358490566 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -0.1327 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.0764 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.0424 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense
Plasmodium falciparum ChEMBL23 20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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