Detailed information for compound 1191584

Basic information

Technical information
  • TDR Targets ID: 1191584
  • Name: 5-[(3S)-dithiolan-3-yl]pentanoic acid
  • MW: 206.326 | Formula: C8H14O2S2
  • H donors: 1 H acceptors: 2 LogP: 1.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCCC[C@@H]1SSCC1
  • InChi: 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m0/s1
  • InChiKey: AGBQKNBQESQNJD-ZETCQYMHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[(3S)-3-dithiolanyl]pentanoic acid
  • 5-[(3S)-dithiolan-3-yl]valeric acid
  • 5-[(3S)-1,2-dithiolan-3-yl]pentanoic acid
  • 1077-27-6
  • (S)-lipoic acid
  • CHEBI:43796
  • 1,2-Dithiolane-3-pentanoic acid, (S)-
  • S-Lipoate
  • Thioctic acid l-form
  • Lopac-T-5625
  • NCGC00016032-01
  • 5-(1,2-dithiolan-3-yl)pentanoato
  • InChI=1/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10
  • (S)-(-)-lipoic acid
  • (S)-1,2-dithiolane-3-pentanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Rattus norvegicus Muscarinic acetylcholine receptor M1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Muscarinic acetylcholine receptor M1   460 aa 425 aa 22.1 %
Schistosoma mansoni amine GPCR Muscarinic acetylcholine receptor M1   460 aa 463 aa 27.0 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Muscarinic acetylcholine receptor M1   460 aa 462 aa 23.4 %
Echinococcus granulosus biogenic amine 5HT receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Echinococcus multilocularis serotonin receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.0308 0.0764
Echinococcus multilocularis tar DNA binding protein 0.0281 0.1534 0.1529
Brugia malayi hypothetical protein 0.0036 0.0089 0.0161
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0091 0.0176
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0091 0.0176
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.016 0.0311
Leishmania major C-8 sterol isomerase-like protein 0.0775 0.4447 1
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0349 0.069
Echinococcus granulosus orexin receptor type 2 0.0048 0.016 0.0311
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0218 0.0213
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0148 0.0143
Echinococcus multilocularis fmrfamide receptor 0.0048 0.016 0.0155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.1828 0.1823
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Echinococcus granulosus neuropeptide receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Echinococcus multilocularis neuropeptide receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0082 0.0361 0.0684
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0281 0.1534 0.2939
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0287 0.0566
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.016 0.0311
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.0147
Brugia malayi 6-phosphofructokinase 0.0131 0.0653 0.1244
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus lamin 0.0033 0.007 0.013
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0684 0.3914 1
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0646
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Brugia malayi Latrophilin receptor protein 2 0.0286 0.1564 0.2997
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.008 0.0349 0.066
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0029 0.0047
Brugia malayi translation initiation factor 4E 0.0042 0.0124 0.0227
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.016 0.0511
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0215 0.021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0148 0.0287
Brugia malayi AKH receptor 0.0048 0.016 0.0298
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0151 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.017
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0096 0.0182
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0286 0.1564 0.2997
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.203 0.4545
Leishmania major ubiquitin-activating enzyme-like protein 0.0038 0.0104 0.0201
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0775 0.4447 0.854
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.0361 0.0684
Brugia malayi RE15519p 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Schistosoma mansoni thyroid hormone receptor 0.0198 0.1045 0.209
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0119 0.0228
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0096 0.0207
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3914 1
Leishmania major eukaryotic translation initiation factor-like 0.0042 0.0124 0.0245
Echinococcus multilocularis muscleblind protein 0.0149 0.0759 0.0754
Trypanosoma brucei trypanothione reductase 0.0057 0.0215 0.0451
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Brugia malayi Dopamine receptor protein 1 0.0048 0.016 0.0298
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0035 0.0082 0.1003
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0732 0.1825
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0335 0.0662
Brugia malayi MH2 domain containing protein 0.0026 0.0029 0.0045
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0079 0.0345 0.0831
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0647 0.1605
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.016 0.0155
Echinococcus multilocularis fmrfamide receptor 0.0048 0.016 0.0155
Echinococcus granulosus neuropeptide receptor 0.0048 0.016 0.0311
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.016 0.0311
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.016 0.0298
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0215 0.0421
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0091 0.0085
Schistosoma mansoni DNA helicase recq5 0.0035 0.0082 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0653 0.2431
Chlamydia trachomatis endonuclease IV 0.0093 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0124
Brugia malayi nuclear hormone receptor 0.0046 0.0148 0.0274
Onchocerca volvulus Peroxidase homolog 0.0032 0.0066 0.0198
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0148 0.0274
Brugia malayi Pre-SET motif family protein 0.0462 0.2602 0.4991
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0148 0.0143
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Brugia malayi mbt repeat family protein 0.0058 0.0218 0.0408
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0165 0.085 0.1699
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0329 0.065
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi nuclear receptor NHR-88 0.0046 0.0148 0.0274
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0038 0.0104 0.0198
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0091 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Schistosoma mansoni biogenic amine (5HT) receptor 0.0299 0.1641 0.3289
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0029 0.0023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0462 0.2602 0.4991
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0896 0.1988
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.016 0.0311
Brugia malayi MH1 domain containing protein 0.0026 0.0029 0.0045
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0101 0.0046
Plasmodium vivax ubiquitin activating enzyme, putative 0.0058 0.0222 0.4671
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Treponema pallidum licC protein (licC) 0.0125 0.0618 0.2302
Loa Loa (eye worm) hypothetical protein 0.0903 0.5207 1
Echinococcus multilocularis sex peptide receptor 0.0048 0.016 0.0155
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0058 0.0222 0.0434
Brugia malayi polk-prov protein 0.0045 0.0142 0.0263
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0134 0.0259
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.016 0.0155
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0022 0.0031
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.016 0.0311
Schistosoma mansoni DNA polymerase eta 0.0072 0.03 0.0592
Onchocerca volvulus 0.0046 0.0148 0.0471
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Brugia malayi Thioredoxin reductase 0.0057 0.0215 0.0403
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0091 0.0176
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Mycobacterium ulcerans lipase LipD 0.0036 0.0091 0.0193
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Onchocerca volvulus 0.0048 0.016 0.0511
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.1783
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0029 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0096 0.0148
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.016 0.0311
Onchocerca volvulus 0.008 0.0349 0.1133
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.016 0.0311
Brugia malayi neuropeptide F receptor 0.0048 0.016 0.0298
Brugia malayi ORL1-like opioid receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0148 0.0143
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0261 0.0555
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0882 0.1761
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0148 0.0471
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0118
Echinococcus multilocularis lamin 0.0033 0.007 0.0065
Schistosoma mansoni hypothetical protein 0.0077 0.0335 0.0662
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0044 0.0065
Echinococcus multilocularis orexin receptor type 2 0.0048 0.016 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0142 0.0287
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Brugia malayi Bromodomain containing protein 0.0095 0.0438 0.0831
Brugia malayi hypothetical protein 0.0024 0.0021 0.0029
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0073 0.013
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0074
Trichomonas vaginalis set domain proteins, putative 0.0525 0.2978 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.016 0.0298
Echinococcus multilocularis zinc finger protein 0.0028 0.0043 0.0037
Loa Loa (eye worm) Smad1 0.0026 0.0029 0.0045
Schistosoma mansoni hypothetical protein 0.0358 0.1988 0.3985
Toxoplasma gondii hypothetical protein 0.0058 0.0222 0.3585
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Brugia malayi ThiF family protein 0.0058 0.0222 0.0415
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Brugia malayi sulfakinin receptor protein 0.0048 0.016 0.0298
Leishmania major DNA polymerase kappa, putative 0.0049 0.0166 0.034
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0096 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0148 0.0274
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0148 0.0287
Schistosoma mansoni hypothetical protein 0.0865 0.4979 1
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0349 0.0343
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis serotonin transporter 0.047 0.265 0.2646
Schistosoma mansoni lipoxygenase 0.0119 0.0583 0.1161
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.0869 0.2704
Loa Loa (eye worm) hypothetical protein 0.0618 0.3521 0.6758
Brugia malayi G protein-coupled receptor 0.0048 0.016 0.0298
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0171
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0157 0.1224
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0361 0.0715
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.016 0.0155
Schistosoma mansoni DNA helicase recq1 0.0035 0.0082 0.0154
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0119 0.0249
Echinococcus multilocularis GPCR, family 2 0.0286 0.1564 0.1559
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Brugia malayi putative neuropeptide receptor 0.0048 0.016 0.0298
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0125 0.0618 1
Leishmania major eukaryotic translation initiation factor-like protein 0.0042 0.0124 0.0245
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0308 0.0752
Brugia malayi glutaminase DH11.1 0.0317 0.1747 0.3348
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0583 0.1161
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi RNA binding protein 0.0281 0.1534 0.2939
Echinococcus granulosus dna polymerase eta 0.0072 0.03 0.0592
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0096 0.003
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.03 0.0643
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Mycobacterium leprae Probable lipase LipE 0.0036 0.0091 0.0176
Loa Loa (eye worm) hypothetical protein 0.0085 0.0382 0.0724
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0759 0.0754
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0096 0.0001
Onchocerca volvulus Dual oxidase homolog 0.0032 0.0066 0.0198
Loa Loa (eye worm) hypothetical protein 0.0056 0.0207 0.0388
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Schistosoma mansoni lipoxygenase 0.0084 0.0371 0.0734
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0088 0.1142
Brugia malayi Muscleblind-like protein 0.0149 0.0759 0.1448
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Loa Loa (eye worm) glutathione reductase 0.0057 0.0215 0.0403
Echinococcus multilocularis Smad4 0.0026 0.0029 0.0023
Schistosoma mansoni lamin 0.0033 0.007 0.013
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.016 0.0155
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0091 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Echinococcus multilocularis peroxidasin 0.0032 0.0066 0.006
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0148 0.0274
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0088 0.1415
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.1828 0.3663
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0091 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0148 0.0274
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0044 0.0065
Plasmodium falciparum transporter, putative 0.008 0.0349 0.8015
Schistosoma mansoni retinoic acid receptor RXR 0.0165 0.085 0.1699
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0424 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0269 0.0263
Plasmodium falciparum thioredoxin reductase 0.0057 0.0215 0.4499
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.016 0.0311
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0218 0.0427
Schistosoma mansoni smad 0.0026 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0148 0.0274
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.133
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0134 0.2174
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0088 0.1142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0287 0.0281
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0155
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0148 0.0287
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0589 0.1173
Schistosoma mansoni lozenge 0.0067 0.0274 0.054
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0424 1
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0125 0.0618 0.1547
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.016 0.0155
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Toxoplasma gondii exonuclease III APE 0.0037 0.0096 0.155
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.0869 0.2704
Leishmania major trypanothione reductase 0.0057 0.0215 0.0451
Trichomonas vaginalis glutaminase, putative 0.0317 0.1747 0.5742
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0653 0.162
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0732 0.1825
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Echinococcus granulosus geminin 0.0865 0.4979 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0349 0.0659
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0148 0.0143
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0697
Schistosoma mansoni hypothetical protein 0.0865 0.4979 1
Echinococcus multilocularis dna polymerase eta 0.0072 0.03 0.0295
Echinococcus multilocularis allatostatin A receptor 0.0048 0.016 0.0155
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0215 0.0403
Plasmodium vivax hypothetical protein, conserved 0.008 0.0349 0.8015
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0218 0.0408
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0349 0.069
Toxoplasma gondii ThiF family protein 0.0038 0.0104 0.1686
Mycobacterium ulcerans hypothetical protein 0.0027 0.0039 0.0062
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0155
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0066 0.0198
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0199 0.4069
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0148 0.0287
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0349 0.069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0148 0.0274
Onchocerca volvulus 0.0033 0.007 0.0214
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0091 0.0171
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.203 0.4545
Brugia malayi Melatonin receptor type 1A 0.0048 0.016 0.0298
Plasmodium falciparum glutathione reductase 0.0057 0.0215 0.4499
Echinococcus granulosus intermediate filament protein 0.0033 0.007 0.013
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.0928 0.1854
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0096 0.0173
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.0928 0.1773
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0079 0.0345 0.0847
Loa Loa (eye worm) carboxylesterase 0.0082 0.0361 0.0684
Brugia malayi follicle stimulating hormone receptor 0.0048 0.016 0.0298
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0589 0.1173
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0134 0.0129
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0096 0.003
Brugia malayi hypothetical protein 0.0535 0.3033 0.5821
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0035 0.0082 0.0154
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0349 0.0343
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) MBCTL1 0.0066 0.0265 0.0499
Echinococcus granulosus lamin dm0 0.0033 0.007 0.013
Brugia malayi nuclear receptor RXR 0.0024 0.0021 0.0029
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0148 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0148 0.0274
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0349 0.069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0265 0.0522
Brugia malayi beta-lactamase 0.0036 0.0091 0.0163
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Trichomonas vaginalis esterase, putative 0.0036 0.0091 0.0011
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0653 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0349 0.069
Onchocerca volvulus 0.0048 0.016 0.0511
Brugia malayi G-protein coupled receptor 0.0048 0.016 0.0298
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0618 0.1532
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.016 0.0298
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Echinococcus granulosus g-protein coupled receptor 0.0048 0.016 0.0311
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0329 0.0323
Brugia malayi Calcitonin receptor-like protein seb-1 0.0903 0.5207 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0096 0.0182
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0096 0.0151
Brugia malayi intermediate filament protein 0.0033 0.007 0.0124
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0269 0.0529
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0067 0.0134
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0096 0.0182
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.016 0.0511
Loa Loa (eye worm) hypothetical protein 0.0149 0.0759 0.1448
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni hypothetical protein 0.0618 0.3521 0.7068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0148 0.0274
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1234 0.3115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0148 0.0274
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.016 0.0155
Onchocerca volvulus 0.047 0.265 0.8734
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0424 0.0805
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0101 0.0193
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0361 0.0356
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) blistered cuticle protein 3 0.0032 0.0066 0.0115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0021 0.0031
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.016 0.0311
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0775 0.077
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0096 0.0182
Echinococcus granulosus sex peptide receptor 0.0048 0.016 0.0311
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.133
Loa Loa (eye worm) hypothetical protein 0.0058 0.0218 0.0408
Onchocerca volvulus 0.0048 0.016 0.0511
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0044 0.0065
Onchocerca volvulus 0.0032 0.0066 0.0198
Onchocerca volvulus 0.0048 0.016 0.0511
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0349 0.0659
Onchocerca volvulus 0.0036 0.0091 0.028
Onchocerca volvulus 0.0036 0.0091 0.028
Onchocerca volvulus 0.0066 0.0269 0.087
Giardia lamblia DINP protein human, muc B family 0.0049 0.0166 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.016 0.0155
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) runx1 0.0067 0.0274 0.0516
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0265 0.0522
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.1783
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0148 0.0274
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0153 0.2865
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0148 0.0471
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0172 0.0291
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0119 0.0218
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0087 0.039 0.0385
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0349 0.069
Brugia malayi Peroxidasin 0.0032 0.0066 0.0115
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.0928 0.0922
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0148 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0091 0.0176
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.004 0.0112 0.0204
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0349 0.069
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Loa Loa (eye worm) hypothetical protein 0.0053 0.0194 0.0362
Onchocerca volvulus 0.0032 0.0066 0.0198
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.203 0.4545
Onchocerca volvulus 0.008 0.0349 0.1133
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0036 0.0093
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Brugia malayi Serotonin receptor 0.0048 0.016 0.0298
Leishmania major DNA polymerase eta, putative 0.0072 0.03 0.0643
Schistosoma mansoni coup transcription factor 0.0046 0.0148 0.0287
Brugia malayi hypothetical protein 0.008 0.0349 0.066
Mycobacterium ulcerans hypothetical protein 0.0125 0.0618 0.1547
Loa Loa (eye worm) hypothetical protein 0.0072 0.03 0.0567
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0148 0.0143
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0589 0.0584
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0148 0.0274
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0215 0.4499
Brugia malayi 6-phosphofructokinase 0.0131 0.0653 0.1244
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.016 0.0311
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0215 0.0496
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0218 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0148 0.0274
Mycobacterium ulcerans glutaminase 0.0317 0.1747 0.4442
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0775 0.4447 1
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0088 0.1415
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.008 0.0349 0.0343
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0152 0.0281
Loa Loa (eye worm) inositol-1 0.0037 0.0096 0.0174
Loa Loa (eye worm) hypothetical protein 0.0535 0.3033 0.5821
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0681
Echinococcus multilocularis musashi 0.0033 0.007 0.0065
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.0361 0.0356
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.016 0.0298
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.2091 0.401
Echinococcus granulosus tar DNA binding protein 0.0281 0.1534 0.3073
Onchocerca volvulus 0.0525 0.2978 0.9817
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Onchocerca volvulus 0.0048 0.016 0.0511
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0096 0.1361
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0042 0.0124 0.0118
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0247 0.0523
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0079 0.0345 0.0847
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.016 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0148 0.0274
Loa Loa (eye worm) acetyltransferase 0.0178 0.0928 0.1773
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0308 0.0661
Brugia malayi GnHR receptor homolog 0.0048 0.016 0.0298
Mycobacterium ulcerans hypothetical protein 0.0036 0.0091 0.0193
Toxoplasma gondii hypothetical protein 0.0059 0.0225 0.3643
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0134 0.0269
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0349 0.0343
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.016 0.0311
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.016 0.0155
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.016 0.0298
Mycobacterium ulcerans hypothetical protein 0.0024 0.0022 0.0017
Brugia malayi hypothetical protein 0.0028 0.0044 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Echinococcus granulosus dna polymerase kappa 0.0073 0.0308 0.0608
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0218 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0119 0.0218
Schistosoma mansoni sodium-dependent amino acid transporter 0.008 0.0349 0.069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0335 0.0662
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0259 0.0488
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.016 0.0298
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0199 0.0385
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0287 0.0566
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi steroid hormone receptor 0.0046 0.0148 0.0274
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0148 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0148 0.0274
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0029 0.0023
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.016 0.0311
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0025 0.0038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis dna polymerase kappa 0.0073 0.0308 0.0303
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0647 0.1605
Onchocerca volvulus 0.0033 0.007 0.0214
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0038 0.0104 0.0201
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0424 0.1034
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0653 0.162
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0039 0.0033
Brugia malayi hypothetical protein 0.0077 0.0335 0.0633
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0018
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.016 0.0298
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.033 0.1828 0.3503
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.016 0.0311
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0535 0.3033 0.5821
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0042 0.0124 0.2005
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0073 0.0132
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0589 0.1294
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.0499
Onchocerca volvulus Chorion peroxidase homolog 0.0032 0.0066 0.0198
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0035 0.0082 0.0077
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Dopamine receptor 0.0048 0.016 0.0298
Schistosoma mansoni Smad4 0.0026 0.0029 0.0047
Schistosoma mansoni thyroid hormone receptor 0.0198 0.1045 0.209
Schistosoma mansoni zinc finger protein 0.0028 0.0043 0.0075
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.016 0.0155
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus granulosus acetylcholinesterase 0.0082 0.0361 0.0715
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0127
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.016 0.0298
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0111 0.0535 0.1332
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0286 0.1564 0.3134
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0119 0.0228
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.016 0.0155
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0053 0.0236
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0647 0.1605
Loa Loa (eye worm) hypothetical protein 0.0299 0.1641 0.3145
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0287 0.0613
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.016 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0349 0.069
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0148 0.0274
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.0708 0.0703
Leishmania major DNA polymerase eta, putative 0.0043 0.0134 0.0269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0142 0.0287
Mycobacterium ulcerans epimerase 0.0024 0.0022 0.0017
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) latrophilin receptor protein 2 0.0286 0.1564 0.2997
Loa Loa (eye worm) hypothetical protein 0.047 0.265 0.5084
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.016 0.0311
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Trypanosoma brucei C-8 sterol isomerase, putative 0.0775 0.4447 1
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0172 0.0319
Loa Loa (eye worm) hypothetical protein 0.0286 0.1564 0.2997
Brugia malayi Cytochrome P450 family protein 0.0023 0.0015 0.0018
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.203 0.4545
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.033 0.1828 0.1823
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Mycobacterium ulcerans hypothetical protein 0.0125 0.0618 0.1547
Echinococcus granulosus carboxylesterase 5A 0.0082 0.0361 0.0715
Toxoplasma gondii ABC1 family protein 0.0036 0.0091 0.1465
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0088 0.1142
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0653 0.1244
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0311
Schistosoma mansoni glutaminase 0.0317 0.1747 0.3501
Loa Loa (eye worm) hypothetical protein 0.0082 0.0361 0.0684
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0091 0.0193
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0021 0.0031
Schistosoma mansoni adenoreceptor 0.0048 0.016 0.0311
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0653 0.1301
Echinococcus multilocularis bloom syndrome protein 0.005 0.0172 0.0166
Toxoplasma gondii thioredoxin reductase 0.0057 0.0215 0.3479
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0096 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0101 0.0234
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0096 0.1361
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Brugia malayi hypothetical protein 0.0024 0.0021 0.0029
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0038 0.0104 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.016 0.0298
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0286 0.1564 0.1559
Leishmania major hypothetical protein, conserved 0.0036 0.0091 0.017
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0057 0.0213 0.0507
Echinococcus granulosus GPCR family 2 0.0286 0.1564 0.3134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.033 0.1828 0.3663
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0308 0.0752
Brugia malayi Carboxylesterase family protein 0.0082 0.0361 0.0684
Mycobacterium ulcerans beta-lactamase 0.0036 0.0091 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0166 0.034
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0035 0.0082 0.0077
Brugia malayi MH2 domain containing protein 0.0026 0.0029 0.0045
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.016 0.0298
Onchocerca volvulus 0.008 0.0349 0.1133
Echinococcus granulosus acetylcholinesterase 0.0082 0.0361 0.0715
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0021 0.0031
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0066 0.0198
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0029 0.0047
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.033 0.1828 0.3663
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0087 0.039 0.074
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0031
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0044 0.0713
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Echinococcus granulosus serotonin transporter 0.047 0.265 0.5317
Brugia malayi hypothetical protein 0.0036 0.0089 0.0161
Schistosoma mansoni peroxidasin 0.0032 0.0066 0.012
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0049 0.0794
Echinococcus multilocularis lamin dm0 0.0033 0.007 0.0065
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0349 0.069
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0234 0.1261 0.2524
Toxoplasma gondii hypothetical protein 0.008 0.0349 0.5641
Brugia malayi Inositol-1 0.0037 0.0096 0.0174
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0218 0.0427
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Plasmodium falciparum amino acid transporter, putative 0.008 0.0349 0.8015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Brugia malayi Blistered cuticle protein 3 0.0032 0.0066 0.0115
Echinococcus granulosus smad 0.0026 0.0029 0.0047
Brugia malayi MH1 domain containing protein 0.0026 0.0029 0.0045
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0088 0.1142
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0199 0.3215
Echinococcus granulosus histone lysine methyltransferase setb 0.0087 0.039 0.0774
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0589 0.1471
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.016 0.0311
Plasmodium vivax SET domain protein, putative 0.0066 0.0269 0.5914
Onchocerca volvulus 0.0032 0.0066 0.0198
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.016 0.0311
Brugia malayi Pre-SET motif family protein 0.0066 0.0269 0.0506
Brugia malayi hypothetical protein 0.0032 0.0066 0.0115
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0053 0.019 0.0371
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0234 0.1261 0.1256
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.008 0.0349 0.069
Echinococcus granulosus fmrfamide receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0029 0.0045
Echinococcus granulosus serotonin receptor 0.0048 0.016 0.0311
Mycobacterium ulcerans endonuclease IV 0.0093 0.0424 0.1049
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.007 0.0124
Schistosoma mansoni inositol monophosphatase 0.0037 0.0096 0.0182
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0039 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.039 0.0774
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.0166 0.034
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.005 0.0172 0.0402
Echinococcus multilocularis serotonin receptor 0.0299 0.1641 0.1637
Mycobacterium ulcerans hypothetical protein 0.0192 0.1011 0.2555
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0215 0.0451
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0287 0.0541
Loa Loa (eye worm) hypothetical protein 0.0396 0.2213 0.4245
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0653 0.1438
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.039 0.0774
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Plasmodium vivax glutathione reductase, putative 0.0057 0.0215 0.4499
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0022 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0589 0.1173
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0775 0.4447 0.854
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0286 0.1564 0.3134
Loa Loa (eye worm) hypothetical protein 0.0045 0.0142 0.0263
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0148 0.0471
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Trichomonas vaginalis aldehyde oxidase, putative 0.0168 0.0869 0.2704
Schistosoma mansoni smad1 5 8 and 0.0026 0.0029 0.0047
Schistosoma mansoni blooms syndrome DNA helicase 0.0032 0.0068 0.0124
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Schistosoma mansoni hypothetical protein 0.004 0.0112 0.0214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0147
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0148 0.0287
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi glutathione reductase 0.0057 0.0215 0.0403
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0091 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0286 0.1564 0.1559
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Brugia malayi Carboxylesterase family protein 0.0082 0.0361 0.0684
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0088 0.1415
Echinococcus granulosus bloom syndrome protein 0.005 0.0172 0.0333
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0218 0.0213
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0148 0.0287
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0057 0.0213 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0199 0.0385
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0157 0.296
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0096 0.009
Leishmania major hypothetical protein, conserved 0.0028 0.0044 0.0065
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0653 0.1438
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0349 0.0689
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0096 0.003
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.03 0.0643
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.03 0.0567
Loa Loa (eye worm) translation initiation factor 4E 0.0042 0.0124 0.0227
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0684 0.3914 1
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0361 0.0356
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0775 0.1547
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0067 0.0117
Onchocerca volvulus 0.0535 0.3033 1
Brugia malayi Dopamine receptor protein 2 0.0048 0.016 0.0298
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0119 0.0228
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.016 0.0298
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.008 0.0349 0.069
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0119 0.0113
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0653 0.1635
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) solute carrier family 6 member 4 0.047 0.265 0.5084
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.008 0.0349 0.0343
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.016 0.0311
Brugia malayi Serotonin receptor 0.0048 0.016 0.0298
Schistosoma mansoni opsin-like receptor 0.0048 0.016 0.0311
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0119 0.0555
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0096 0.0029
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0077 0.0137
Schistosoma mansoni ap endonuclease 0.0037 0.0096 0.0181
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0653 0.0647
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0039 0.0067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.016 0.0311
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0148 0.0287
Brugia malayi Sodium:neurotransmitter symporter family protein 0.047 0.265 0.5084
Onchocerca volvulus 0.0036 0.0091 0.028
Trypanosoma brucei unspecified product 0.0028 0.0044 0.0065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0181 0.0374
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0349 0.0689
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0021 0.0015
Brugia malayi TAR-binding protein 0.0281 0.1534 0.2939
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0112 0.0106
Treponema pallidum sodium- and chloride- dependent transporter 0.047 0.265 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0299 0.1641 0.3145
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0163
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0096 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0274
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.016 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Schistosoma mansoni inositol monophosphatase 0.0037 0.0096 0.0182
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.033 0.1828 0.3503
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.007 0.0124
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.016 0.0311
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.016 0.0311
Echinococcus multilocularis somatostatin receptor 0.0048 0.016 0.0155
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.016 0.0155
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0181 0.0374
Echinococcus multilocularis geminin 0.0865 0.4979 0.4976
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0647 0.1605
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0265 0.0522
Plasmodium vivax amine transporter, putative 0.008 0.0349 0.8015
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Loa Loa (eye worm) beta-lactamase 0.0036 0.0091 0.0163
Echinococcus multilocularis Protein lozenge 0.0067 0.0274 0.0269
Onchocerca volvulus 0.0048 0.016 0.0511
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0096 0.019
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.047 0.265 0.5317
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.016 0.0155
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0172 0.0291
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.016 0.0298
Echinococcus multilocularis neuropeptide receptor 0.0048 0.016 0.0155
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi mbt repeat family protein 0.0058 0.0218 0.0408
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0335 0.0329
Schistosoma mansoni hypothetical protein 0.0286 0.1564 0.3134
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) glutaminase 0.0317 0.1747 0.3348
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0148 0.0287
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Echinococcus granulosus zinc finger protein 0.0028 0.0043 0.0075
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0091 0.0176
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0218 0.0702
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0589 0.9523
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0058 0.0222 0.0216
Schistosoma mansoni hypothetical protein 0.0025 0.0025 0.0039
Echinococcus granulosus neuropeptide s receptor 0.0048 0.016 0.0311
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0308 0.0661
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0349 0.4619
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0088 0.029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0618 0.1532
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0088 0.0629
Echinococcus granulosus g protein coupled receptor 0.0048 0.016 0.0311
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) serotonin transporter b 0.047 0.265 0.5084
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0151 0.0145
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.016 0.0311
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.5641
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Schistosoma mansoni myosin xvIII 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.016 0.0311
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0073 0.0132
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0896 0.1988
Entamoeba histolytica hypothetical protein 0.0077 0.0335 0.4379
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.016 0.0311
Brugia malayi phosphofructokinase 0.0131 0.0653 0.1244
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0148 0.0274
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.008 0.0349 0.7759
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0199 0.0388
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0091 0.1223
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0148 0.0274
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0349 0.0752
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0091 0.0176
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0035 0.0082 0.0147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0903 0.5207 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0269 0.4349
Schistosoma mansoni lamin 0.0033 0.007 0.013
Brugia malayi ThiF family protein 0.0038 0.0104 0.019
Schistosoma mansoni intermediate filament proteins 0.0033 0.007 0.013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Schistosoma mansoni sodium/chloride dependent transporter 0.047 0.265 0.5317
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.016 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0148 0.0274
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0311
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0653 0.1301
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) glutaminase 2 0.0317 0.1747 0.3348
Brugia malayi MH2 domain containing protein 0.0375 0.2091 0.401
Loa Loa (eye worm) RNA binding protein 0.0281 0.1534 0.2939
Echinococcus multilocularis serotonin receptor 0.0299 0.1641 0.1637
Brugia malayi ecdysteroid receptor 0.0046 0.0148 0.0274
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0176
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0029 0.0047
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0148 0.0287
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0058 0.0222 0.4671
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0042 0.0124 0.0245
Schistosoma mansoni peroxidasin 0.0032 0.0066 0.012
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.008 0.0349 0.0343
Trypanosoma brucei unspecified product 0.0065 0.0261 0.0555
Echinococcus granulosus biogenic amine 5HT receptor 0.0299 0.1641 0.3289
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0082 0.0147
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0038 0.0104 0.1583
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0199 0.3215
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Loa Loa (eye worm) norepinephrine transporter 0.047 0.265 0.5084
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3914 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1011 0.2542
Schistosoma mansoni ap endonuclease 0.0037 0.0096 0.0181
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0067 0.0134
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0148 0.0274
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.0166 0.037
Schistosoma mansoni bromodomain containing protein 0.0081 0.0354 0.0701
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0148 0.0274
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0732 0.1825
Echinococcus granulosus muscleblind protein 0.0149 0.0759 0.1514
Echinococcus granulosus peroxidasin 0.0032 0.0066 0.012
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0349 0.0752
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0647 0.1605
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.016 0.0298
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0038 0.0104 0.0201
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0653 0.1244
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0091 0.0193
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0011
Schistosoma mansoni histamine h1 receptor 0.0048 0.016 0.0311
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.016 0.0311
Echinococcus granulosus Smad4 0.0026 0.0029 0.0047
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0148 0.0287
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0035 0.0082 0.0154
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Loa Loa (eye worm) hypothetical protein 0.008 0.0349 0.066
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.0308 0.0764
Onchocerca volvulus 0.0048 0.016 0.0511
Loa Loa (eye worm) hypothetical protein 0.0058 0.0222 0.0415
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus multilocularis smad 0.0026 0.0029 0.0023
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0091 0.0171
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0148 0.0287
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0112 0.0204
Brugia malayi Cytochrome P450 family protein 0.0034 0.0077 0.0137
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.016 0.0155
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0148 0.0287
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0096 0.0181
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0653 0.1438
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0148 0.0143
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0015 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0732 0.1825
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0653 0.1955
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0647 0.1605
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Echinococcus granulosus somatostatin receptor 0.0048 0.016 0.0311
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.017
Onchocerca volvulus 0.0058 0.0218 0.0702
Brugia malayi Bromodomain containing protein 0.0051 0.0176 0.0328
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Brugia malayi hypothetical protein 0.0048 0.016 0.0298
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0066 0.0115
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0424 0.1034
Loa Loa (eye worm) RecQ helicase 0.005 0.0172 0.0319
Loa Loa (eye worm) intermediate filament protein 0.0033 0.007 0.0124
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0091 0.017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0269 0.0529
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0218 0.0427
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0096 0.0182
Brugia malayi RNA recognition motif domain containing protein 0.0281 0.1534 0.2939
Brugia malayi larval opioid receptor 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0149 0.0759 0.1448
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0349 0.069
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni amine GPCR 0.0448 0.252 0.5055
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0896 0.1988
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0265 0.026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0096 0.0182
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0112 0.1809
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0096 0.1554
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0903 0.5207 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0096 0.0322
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0096 0.1626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0148 0.0274
Brugia malayi G-protein coupled receptor 0.0048 0.016 0.0298
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0646
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0038 0.0104 0.1583
Brugia malayi Smad1 0.0026 0.0029 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Echinococcus multilocularis thyroid hormone receptor alpha 0.0198 0.1045 0.104
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0057 0.0213 0.0507
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0038 0.0104 0.0099
Trypanosoma brucei unspecified product 0.0028 0.0044 0.0065
Loa Loa (eye worm) ThiF family protein 0.0038 0.0104 0.019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0163
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.016 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Treponema pallidum hypothetical protein 0.0027 0.0039 0.0108
Onchocerca volvulus 0.0048 0.016 0.0511
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.016 0.0155
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0349 0.066
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0029
Toxoplasma gondii endonuclease IV APN 0.0093 0.0424 0.6861
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0653 0.1301
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.016 0.0311
Onchocerca volvulus 0.0048 0.016 0.0511
Schistosoma mansoni neuropeptide receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.016 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0148 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0115
Mycobacterium tuberculosis Probable reductase 0.013 0.0647 0.1605
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0287 0.0697
Schistosoma mansoni tar DNA-binding protein 0.0281 0.1534 0.3073
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.2091 0.401
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.016 0.0311
Schistosoma mansoni amine GPCR 0.0048 0.016 0.0311
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0583 0.0578
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0042 0.0124 0.0126
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.016 0.0311
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0653 0.1244
Schistosoma mansoni hypothetical protein 0.0152 0.0775 0.1547
Onchocerca volvulus 0.0048 0.016 0.0511
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0042 0.0124 0.0245
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.016 0.0298
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0281 0.1534 0.2939
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0058 0.0222 0.0434
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.016 0.0298
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.016 0.0311
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0042 0.0124 0.0238
Brugia malayi neuropeptide F receptor 0.0048 0.016 0.0298
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0265 0.026
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0308 0.0661
Schistosoma mansoni biogenic amine receptor 0.0048 0.016 0.0311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.016 0.0311
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0148 0.0274
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0171
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0265 0.0499
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0042 0.0124 0.0238
Brugia malayi PHD-finger family protein 0.0034 0.0081 0.0145
Echinococcus granulosus allatostatin A receptor 0.0048 0.016 0.0311
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.016 0.0311
Toxoplasma gondii hypothetical protein 0.008 0.0349 0.5641
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0589 0.1457
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0096 0.0207
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0255 0.05
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0157 0.8895
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0011
Echinococcus granulosus hypothetical protein 0.0048 0.016 0.0311
Brugia malayi latrophilin 2 splice variant baaae 0.0618 0.3521 0.6758
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298
Onchocerca volvulus Peroxidase homolog 0.0032 0.0066 0.0198
Echinococcus multilocularis g protein coupled receptor 0.0048 0.016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0093 0.0424 0.0805
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0298

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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