Detailed information for compound 1330852

Basic information

Technical information
  • TDR Targets ID: 1330852
  • Name: 1,1-dioxo-4-piperidin-1-ylthiolan-3-ol
  • MW: 219.301 | Formula: C9H17NO3S
  • H donors: 1 H acceptors: 3 LogP: -0.29 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1CS(=O)(=O)CC1N1CCCCC1
  • InChi: 1S/C9H17NO3S/c11-9-7-14(12,13)6-8(9)10-4-2-1-3-5-10/h8-9,11H,1-7H2
  • InChiKey: SNEPMRMWHXCLPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,1-dioxo-4-(1-piperidyl)thiolan-3-ol
  • 1,1-dioxo-4-(1-piperidyl)-3-thiolanol
  • 1,1-diketo-4-piperidino-thiolan-3-ol
  • 1,1-dioxo-4-piperidin-1-yl-thiolan-3-ol
  • MLS000528518
  • Oprea1_477384
  • ST5020415
  • 1,1-Dioxo-4-piperidin-1-yl-tetrahydro-1lambda*6*-thiophen-3-ol
  • BAS 04881291
  • IDI1_009675
  • IFLab1_003568
  • SMR000121093

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0089 0.0402 0.1073
Trypanosoma cruzi katanin-like protein, putative 0.0016 0.0002 0.0007
Brugia malayi Pre-SET motif family protein 0.0203 0.1023 0.2733
Mycobacterium tuberculosis Probable lipase LipD 0.0184 0.0917 0.1452
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0133 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0574 0.3042 0.8127
Trypanosoma cruzi katanin, putative 0.0016 0.0002 0.0007
Loa Loa (eye worm) beta-lactamase 0.0184 0.0917 0.245
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.1205 0.3219
Brugia malayi DNA polymerase delta catalytic subunit 0.0703 0.3743 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.001 0.0021
Schistosoma mansoni hypothetical protein 0.0032 0.009 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0025 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0044 0.0119
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0117 0.0554 0.1479
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Trichomonas vaginalis spermatogenesis associated factor, putative 0.031 0.1604 0.4282
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Trypanosoma cruzi Valosin-containing protein, putative 0.0294 0.1517 0.4053
Brugia malayi hypothetical protein 0.0463 0.2436 0.6509
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0025 0.0025
Trichomonas vaginalis DNA polymerase II, putative 0.0232 0.1178 0.3144
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0068
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.034 0.0907
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0025 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0609 0.0875
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0024 0.0044 0.0045
Treponema pallidum fructose-bisphosphate aldolase 0.0627 0.3328 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0091 0.0243
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0099 0.0265
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0117 0.0554 0.1479
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Loa Loa (eye worm) vesicle-fusing ATPase 0.0182 0.0906 0.242
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0133 0.0356
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0609 0.0875
Entamoeba histolytica hypothetical protein 0.0109 0.0508 0.1351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Plasmodium vivax SET domain protein, putative 0.003 0.0077 0.0206
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.1071 0.1696
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0138 0.0367
Trypanosoma cruzi katanin, putative 0.0016 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0094 0.043 0.1148
Brugia malayi Cytochrome P450 family protein 0.0019 0.002 0.0053
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0003 0.0005
Trypanosoma brucei katanin, putative 0.0016 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0129 0.0617 0.1647
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0138 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0232 0.1178 0.3144
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0093 0.0248
Schistosoma mansoni bromodomain containing protein 0.0076 0.0331 0.0476
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0207 0.0297
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0091 0.0237
Plasmodium vivax exodeoxyribonuclease III, putative 0.0024 0.0044 0.0119
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0138 0.0361
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0003 0.0005
Echinococcus granulosus neuropeptide s receptor 0.1824 0.9848 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0024 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0061 0.0247 0.0659
Echinococcus multilocularis cysteine protease 0.0034 0.0099 0.0099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0025 0.0025
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0099 0.0099
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0247 0.0251
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.031 0.1604 0.1604
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0091 0.0243
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0025 0.0037
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0091 0.0243
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0099 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0068
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0207 0.0207
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0232 0.1178 0.3149
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0232 0.1178 0.3149
Echinococcus granulosus FTZ F1 alpha 0.002 0.0025 0.0026
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Plasmodium falciparum thioredoxin reductase 0.0032 0.0091 0.0243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0254 0.0679
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0109 0.0508 0.1351
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0253 0.04
Brugia malayi nuclear receptor NHR-88 0.002 0.0025 0.0068
Brugia malayi ecdysteroid receptor 0.002 0.0025 0.0068
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0103 0.0477 0.1276
Trypanosoma brucei katanin, putative 0.0016 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0324
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0121 0.0323
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0099 0.0143
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0003 0.0009
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0024 0.0044 0.0119
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0024 0.0044 0.0119
Brugia malayi Cathepsin L-like precursor 0.0034 0.0099 0.0265
Loa Loa (eye worm) inositol-1 0.0038 0.0121 0.0323
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0025 0.0025
Plasmodium falciparum DNase I-like protein, putative 0.0024 0.0044 0.0119
Leishmania major trypanothione reductase 0.0093 0.0422 0.1128
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0099 0.0257
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0232 0.1178 0.3143
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.001 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0025 0.0026
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Onchocerca volvulus Putative neutral sphingomyelinase 0.0024 0.0044 0.011
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0013
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0121 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0044 0.0119
Toxoplasma gondii exonuclease III APE 0.0117 0.0554 0.1479
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.002 0.0053
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0112
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0138 0.0367
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0121 0.0317
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0703 0.3743 1
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0128 0.0614 0.164
Brugia malayi fidgetin protein 0.0016 0.0002 0.0007
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0548
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.001 0.0021
Trypanosoma brucei unspecified product 0.0041 0.0138 0.0367
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0091 0.0243
Echinococcus granulosus neuropeptide receptor A26 0.1824 0.9848 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0091 0.0243
Brugia malayi exodeoxyribonuclease III family protein 0.0117 0.0554 0.1479
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0068
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Brugia malayi vps4b-prov protein 0.0016 0.0002 0.0007
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0232 0.1178 0.3149
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0202 0.0539
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0052 0.0139
Mycobacterium tuberculosis Conserved protein 0.0184 0.0917 0.1452
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0158 0.0777 0.0777
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Schistosoma mansoni DNA polymerase eta 0.0041 0.0138 0.0198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0091 0.0243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1959 0.2814
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.002 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0039 0.0097
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0222 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0025 0.0068
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0703 0.3743 1
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0024 0.0044 0.0044
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0294 0.1517 0.4053
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0052 0.0139
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0703 0.3743 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0068
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Echinococcus granulosus cpg binding protein 0.0032 0.0091 0.0092
Brugia malayi Cytochrome P450 family protein 0.0019 0.002 0.0053
Schistosoma mansoni inositol monophosphatase 0.0038 0.0121 0.0174
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0179 0.0472
Echinococcus granulosus intermediate filament protein 0.0081 0.0359 0.0364
Brugia malayi Ets-domain containing protein 0.0078 0.034 0.0907
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0099 0.0259
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.001 0.0027
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0703 0.3743 1
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0103 0.0477 0.127
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0306 0.1582 1
Toxoplasma gondii DNA polymerase family B protein 0.0232 0.1178 0.3149
Echinococcus multilocularis tumor protein p63 0.0332 0.1722 0.1722
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0091 0.0243
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0232 0.1178 0.1178
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.034 0.0345
Echinococcus granulosus tumor protein p63 0.0332 0.1722 0.1749
Loa Loa (eye worm) hypothetical protein 0.0032 0.009 0.024
Loa Loa (eye worm) hypothetical protein 0.0053 0.0207 0.0552
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0041 0.0111
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0052 0.0052
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0133 0.0356
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Echinococcus multilocularis neuropeptide receptor A26 0.1824 0.9848 0.9848
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0138 0.0218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Schistosoma mansoni hypothetical protein 0.1294 0.6963 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0119
Echinococcus granulosus katanin p60 ATPase containing subunit A1 0.0016 0.0002 0.0002
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0052 0.0082
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0207 0.0297
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0044 0.0119
Loa Loa (eye worm) RNA binding protein 0.0062 0.0254 0.0679
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0025 0.0025
Onchocerca volvulus 0.0024 0.0044 0.011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0425 0.0425
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.031 0.1604 0.1629
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0375 0.1959 0.1959
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0184 0.0917 0.1452
Echinococcus granulosus cathepsin l1 0.0023 0.0039 0.0039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0025 0.0026
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0324
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.0917 0.2445
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0112
Trypanosoma cruzi metalloprotease, putative 0.0016 0.0002 0.0007
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0703 0.3743 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0025 0.0026
Schistosoma mansoni hypothetical protein 0.0032 0.009 0.0129
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0016 0.0002 0.0007
Brugia malayi Cathepsin L-like precursor 0.0034 0.0099 0.0265
Brugia malayi Fli-1 protein 0.0236 0.1203 0.3214
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0179 0.0182
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0061 0.0163
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0039 0.0103
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0091 0.0131
Leishmania major hypothetical protein, conserved 0.0024 0.0044 0.0119
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0128 0.0614 0.0881
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0222 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0044 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Echinococcus granulosus neutral sphingomyelinase 0.0024 0.0044 0.0045
Echinococcus granulosus zinc finger protein 0.0027 0.0065 0.0066
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0024 0.0044 0.0119
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0232 0.1178 0.3144
Plasmodium falciparum thioredoxin reductase 0.0093 0.0422 0.1128
Leishmania major vacuolar protein sorting-associated protein 4 0.0016 0.0002 0.0007
Leishmania major cytochrome p450-like protein 0.0019 0.002 0.0053
Loa Loa (eye worm) VCP protein 0.0128 0.0614 0.164
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0003 0.0002
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0091 0.0243
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0003 0.0005
Brugia malayi Probable ClpP-like protease 0.0094 0.043 0.1148
Echinococcus multilocularis beta LACTamase domain containing family member 0.0184 0.0917 0.0917
Plasmodium vivax vivapain-2 0.0034 0.0099 0.0265
Toxoplasma gondii ABC1 family protein 0.0184 0.0917 0.245
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0025 0.0025
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0184 0.0917 0.245
Trypanosoma brucei hypothetical protein, conserved 0.0184 0.0917 0.245
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0236 0.12 0.1901
Leishmania major hypothetical protein, conserved 0.0024 0.0044 0.0119
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0236 0.12 0.7433
Loa Loa (eye worm) hypothetical protein 0.0463 0.2436 0.6509
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0422 0.0669
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0232 0.1178 0.3143
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.043 0.1148
Loa Loa (eye worm) fli-1 protein 0.0236 0.1203 0.3214
Echinococcus multilocularis microtubule associated protein 2 0.0726 0.3867 0.3867
Schistosoma mansoni hypothetical protein 0.0023 0.0041 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0365
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0133 0.035
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0024 0.0044 0.0119
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0091 0.0237
Brugia malayi glutathione reductase 0.0093 0.0422 0.1128
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Schistosoma mansoni skd/vacuolar sorting 0.0016 0.0002 0.0004
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0247 0.0251
Plasmodium vivax unspecified product 0.0017 0.001 0.0027
Schistosoma mansoni nocturnin 0.0024 0.0044 0.0064
Leishmania major cathepsin L-like protease 0.0034 0.0099 0.0265
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0133 0.0135
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0144 0.0385
Brugia malayi Muscleblind-like protein 0.0146 0.0709 0.1895
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0232 0.1178 0.3149
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0184 0.0917 0.245
Brugia malayi ATPase, AAA family protein 0.0016 0.0002 0.0007
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0044 0.0118
Loa Loa (eye worm) hypothetical protein 0.0184 0.0917 0.245
Echinococcus granulosus dna polymerase kappa 0.0041 0.0138 0.014
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0003 0.0005
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0073 0.0315 0.0835
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0232 0.1178 0.3149
Leishmania major pantothenate kinase subunit, putative 0.0024 0.0044 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.0609 0.0609
Schistosoma mansoni eyes absent homolog 0.0089 0.0402 0.0577
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.0609 0.1627
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0294 0.1517 0.4053
Mycobacterium tuberculosis Probable lipase LipE 0.0184 0.0917 0.1452
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0138 0.0367
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0613 0.1639
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0138 0.0367
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0025 0.0026
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0044 0.0119
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0099 0.0099
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0003 0.0002
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0184 0.0917 0.245
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0121 0.0649
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0133 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0025 0.0068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1023 0.2733
Plasmodium falciparum vacuolar protein sorting-associated protein 4 0.0016 0.0002 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.009 0.024
Onchocerca volvulus 0.0024 0.0044 0.011
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0144 0.0378
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0359 0.0958
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0234 0.1191 0.1191
Echinococcus granulosus survival motor neuron protein 1 0.0463 0.2436 0.2474
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0024 0.0044 0.0119
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0003 0.0003
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0232 0.1178 0.1693
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0091 0.0243
Onchocerca volvulus 0.0094 0.043 0.114
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0138 0.0367
Echinococcus multilocularis dna polymerase eta 0.0041 0.0138 0.0138
Toxoplasma gondii cell division protein CDC48AP 0.0186 0.0926 0.2474
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0117 0.0554 1
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.0609 0.1627
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0117 0.0554 0.0562
Mycobacterium tuberculosis Probable reductase 0.0212 0.1071 0.1696
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0024 0.0044 0.0119
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0222 0.0226
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0044 0.0119
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0025 0.0037
Onchocerca volvulus 0.0231 0.1176 0.3135
Plasmodium vivax hypothetical protein, conserved 0.0184 0.0917 0.245
Leishmania major cathepsin L-like protease 0.0129 0.0616 0.1645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0375 0.1959 0.5234
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0003 0.0009
Brugia malayi mbt repeat family protein 0.0053 0.0207 0.0552
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Schistosoma mansoni cript-related 0.0024 0.0044 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0003 0.0009
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0254 0.0254
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Echinococcus multilocularis fidgetin protein 1 0.0016 0.0002 0.0002
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.031 0.1604 0.428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0181 0.026
Echinococcus granulosus microtubule associated protein 2 0.0726 0.3867 0.3927
Leishmania major RNA-editing complex protein MP100, putative 0.0024 0.0044 0.0119
Onchocerca volvulus 0.0034 0.0099 0.0257
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0709 0.0709
Echinococcus multilocularis neuropeptide s receptor 0.1824 0.9848 0.9848
Echinococcus multilocularis neutral sphingomyelinase 0.0024 0.0044 0.0044
Trypanosoma cruzi vacuolar transport protein 4A, putative 0.0016 0.0002 0.0007
Toxoplasma gondii cell division protein CDC48CY 0.031 0.1604 0.4285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1959 0.2814
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0103 0.0477 0.1276
Toxoplasma gondii katanin-like family protein 0.0016 0.0002 0.0007
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.043 0.0617
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0129 0.0617 0.1647
Plasmodium falciparum glutathione reductase 0.0093 0.0422 0.1128
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Onchocerca volvulus 0.0081 0.0359 0.095
Leishmania major cathepsin L-like protease 0.0129 0.0616 0.1645
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0222 0.0222
Onchocerca volvulus 0.0034 0.0099 0.0257
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0099 0.0265
Loa Loa (eye worm) hypothetical protein 0.0049 0.018 0.0481
Trypanosoma cruzi ISWI complex protein 0.0017 0.0009 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Giardia lamblia Inositol 5-phosphatase 4 0.0024 0.0044 0.0112
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0044 0.0119
Schistosoma mansoni cell division control protein 48 aaa family protein 0.031 0.1604 0.2304
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0917 0.2445
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0061 0.0163
Leishmania major katanin-like protein,serine peptidase, Clan SJ, family S16, putative 0.0016 0.0002 0.0007
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0133 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0138 0.0218
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0024 0.0044 0.0112
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.043 0.1174
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0232 0.1178 0.3149
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0068
Onchocerca volvulus 0.0034 0.0099 0.0257
Schistosoma mansoni zinc finger protein 0.0027 0.0065 0.0093
Brugia malayi vesicle-fusing ATPase 0.0182 0.0906 0.242
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0375 0.1959 0.5234
Loa Loa (eye worm) hypothetical protein 0.0069 0.0292 0.078
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0003 0.0009
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0061 0.0163
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0093 0.0248
Brugia malayi Cathepsin L-like precursor 0.0034 0.0099 0.0265
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0422 0.1128
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Echinococcus granulosus geminin 0.1294 0.6963 0.707
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0099 0.0265
Brugia malayi nuclear hormone receptor 0.002 0.0025 0.0068
Brugia malayi Cathepsin L-like precursor 0.0034 0.0099 0.0265
Brugia malayi MH2 domain containing protein 0.0128 0.0613 0.1639
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Schistosoma mansoni zinc finger protein 0.0017 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0103 0.0477 0.1276
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0135 0.0137
Trichomonas vaginalis Phospholipase C precursor, putative 0.0024 0.0044 0.0112
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0153 0.0408
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0044 0.0119
Mycobacterium tuberculosis Conserved protein 0.0184 0.0917 0.1452
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0091 0.0243
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0025 0.0068
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.034 0.034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0306 0.1582 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0247 0.0247
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.001 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.009 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0375 0.1959 0.1959
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0117 0.0554 0.3417
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0024 0.0044 0.0064
Onchocerca volvulus 0.002 0.0025 0.0059
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0184 0.0917 0.1452
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0121 0.0648
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.043 0.2624
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0144 0.0378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0003 0.0002
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0186 0.0926 0.2474
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0025 0.0068
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0138 0.0367
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0306 0.1582 0.2506
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0044 0.0119
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0703 0.3743 0.3743
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0609 0.377
Echinococcus multilocularis deoxyribonuclease 1 2 0.0024 0.0044 0.0044
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0062 0.0062
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Mycobacterium leprae conserved hypothetical protein 0.0184 0.0917 0.5533
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0133 0.0191
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.0555 0.1483
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0003 0.0005
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0062 0.0063
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.001 0.0027
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0359 0.0958
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0253 0.1074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.009 0.024
Brugia malayi beta-lactamase family protein 0.0184 0.0917 0.245
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0024 0.0044 0.0119
Mycobacterium ulcerans beta-lactamase 0.0184 0.0917 0.5741
Brugia malayi Cathepsin L-like precursor 0.0023 0.0039 0.0103
Mycobacterium ulcerans ATPase 0.0186 0.0926 0.5799
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0138 0.0367
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0121 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0091 0.0456
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0091 0.0243
Brugia malayi beta-lactamase family protein 0.0184 0.0917 0.245
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0003 0.0003
Trypanosoma brucei ISWI complex protein 0.0017 0.0009 0.0024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.001 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0099 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0365
Onchocerca volvulus 0.0081 0.0359 0.095
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0616 0.1645
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.001 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Echinococcus multilocularis cysteine protease 0.0034 0.0099 0.0099
Schistosoma mansoni microtubule-associated protein tau 0.0726 0.3867 0.5554
Echinococcus multilocularis lamin 0.0081 0.0359 0.0359
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0044 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0025 0.0068
Leishmania major cathepsin L-like protease 0.0034 0.0099 0.0265
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0044 0.0112
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0099 0.0265
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0103 0.0477 0.1276
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.0265
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0917 0.2445
Trypanosoma cruzi katanin-like protein, putative 0.0016 0.0002 0.0007
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0181 0.0184
Treponema pallidum NADH oxidase 0.0032 0.0091 0.0142
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0024 0.0044 0.0112
Trypanosoma brucei unspecified product 0.0028 0.0069 0.0183
Echinococcus multilocularis cathepsin L 0.0017 0.001 0.001
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0207 0.0297
Loa Loa (eye worm) acetyltransferase 0.0158 0.0777 0.2077
Brugia malayi DNA polymerase alpha catalytic subunit 0.0232 0.1178 0.3149
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.018 0.0258
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0091 0.0243
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0025 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0091 0.0243
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.009 0.009
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0044 0.0119
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.043 0.043
Schistosoma mansoni synaptojanin 0.0024 0.0044 0.0064
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0044 0.0112
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0091 0.0243
Schistosoma mansoni hypothetical protein 0.0094 0.043 0.0617
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Onchocerca volvulus 0.0053 0.0207 0.0543
Plasmodium vivax glutathione reductase, putative 0.0093 0.0422 0.1128
Trichomonas vaginalis ap endonuclease, putative 0.0117 0.0554 0.1474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Schistosoma mansoni intermediate filament proteins 0.0081 0.0359 0.0515
Mycobacterium ulcerans esterase/lipase LipP 0.0184 0.0917 0.5741
Brugia malayi G-protein alpha subunit 0.0016 0.0003 0.0009
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0061 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0181 0.026
Echinococcus granulosus dna polymerase eta 0.0041 0.0138 0.014
Loa Loa (eye worm) hypothetical protein 0.0049 0.0181 0.0484
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0099 0.0265
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0609 0.377
Trypanosoma cruzi mitochondrial protein 99, putative 0.0024 0.0044 0.0119
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0181 0.0181
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.0739 0.075
Brugia malayi Thioredoxin reductase 0.0093 0.0422 0.1128
Treponema pallidum exodeoxyribonuclease (exoA) 0.0117 0.0554 0.1551
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.001 0.0027
Brugia malayi Cathepsin L-like precursor 0.0023 0.0039 0.0103
Onchocerca volvulus 0.003 0.0077 0.0198
Schistosoma mansoni hypothetical protein 0.0069 0.0292 0.0419
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.002 0.002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0103
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0024 0.0044 0.0119
Leishmania major DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Trypanosoma brucei trypanothione reductase 0.0093 0.0422 0.1128
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0117 0.0554 0.1479
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0466 0.1246
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0236 0.12 0.1901
Echinococcus granulosus cysteine protease 0.0017 0.001 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.025 0.0667
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0232 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.0129 0.0617 0.1647
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.001 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Plasmodium vivax DNA polymerase alpha, putative 0.0232 0.1178 0.3149
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Trypanosoma brucei hypothetical protein, conserved 0.0217 0.1099 0.2937
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.001 0.0021
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0138 0.014
Brugia malayi follicle stimulating hormone receptor 0.0237 0.1205 0.3219
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0254 0.0679
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0232 0.1178 0.1197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Loa Loa (eye worm) hypothetical protein 0.0103 0.0477 0.1276
Schistosoma mansoni synaptojanin 0.0024 0.0044 0.0064
Loa Loa (eye worm) ATPase 0.0016 0.0002 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0466 0.1246
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.0609 0.0965
Brugia malayi CXXC zinc finger family protein 0.0028 0.007 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1176 0.3136
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0025 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1175 0.6313 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0025 0.0068
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0003 0.0002
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0234 0.1191 0.1209
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0232 0.1178 0.3149
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0003 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0069 0.0183
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.001 0.0021
Schistosoma mansoni survival motor neuron protein 0.0094 0.043 0.0617
Brugia malayi beta-lactamase 0.0184 0.0917 0.245
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0112
Mycobacterium ulcerans lipase LipD 0.0184 0.0917 0.5741
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0121 0.0123
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0138 0.0367
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0917 0.2445
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.043 0.2624
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0091 0.0243
Mycobacterium ulcerans hypothetical protein 0.0025 0.0052 0.0205
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0112
Trypanosoma cruzi katanin, putative 0.0016 0.0002 0.0007
Leishmania major cathepsin L-like protease 0.0129 0.0616 0.1645
Echinococcus multilocularis geminin 0.1294 0.6963 0.6963
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.002 0.0053
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.001 0.0027
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0024 0.0044 0.0119
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0003 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0025 0.0068
Echinococcus granulosus synaptojanin 1 0.0024 0.0044 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0365
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0044 0.0119
Echinococcus granulosus tar DNA binding protein 0.0062 0.0254 0.0258
Trypanosoma cruzi vesicular transport protein (CDC48 homologue), putative 0.0016 0.0002 0.0007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0184 0.0917 0.1452
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0703 0.3743 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0025 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.001 0.0021
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0024 0.0044 0.0112
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0103 0.0477 0.1276
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0117 0.0554 0.1479
Plasmodium vivax vivapain-2 0.0034 0.0099 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0039 0.0097
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2118 0.2118
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0068
Mycobacterium tuberculosis Conserved protein 0.0184 0.0917 0.1452
Entamoeba histolytica cdc48-like protein, putative 0.0294 0.1517 0.4049
Entamoeba histolytica cysteine protease, putative 0.0034 0.0099 0.0259
Trypanosoma brucei vacuolar protein sorting-associated protein 4, putative 0.0016 0.0002 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0025 0.0025
Brugia malayi Inositol-1 0.0038 0.0121 0.0323
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0024 0.0044 0.0112
Echinococcus granulosus traf and tnf receptor associated protein 0.0024 0.0044 0.0045
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.001 0.001
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0253 0.0253
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0061 0.0163
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0254 0.0679
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0138 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0138 0.0138
Toxoplasma gondii thioredoxin reductase 0.0093 0.0422 0.1128
Echinococcus multilocularis survival motor neuron protein 1 0.0463 0.2436 0.2436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0232 0.1178 0.3144
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0024 0.0044 0.0119
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0217 0.1099 0.2937
Schistosoma mansoni lamin 0.0081 0.0359 0.0515
Loa Loa (eye worm) hypothetical protein 0.0079 0.0347 0.0927
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0052 0.0053
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0103 0.0477 0.1276
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0365
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0025 0.0026
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0025 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Loa Loa (eye worm) hypothetical protein 0.0146 0.0709 0.1895
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Leishmania major hypothetical protein, conserved 0.0017 0.0009 0.0024
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0024 0.0044 0.0112
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0616 0.1645
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0121 0.0323
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0025 0.0037
Toxoplasma gondii cathepsin CPL 0.0034 0.0099 0.0265
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0091 0.0237
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0466 0.1245
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0309 0.0309
Schistosoma mansoni lamin 0.0081 0.0359 0.0515
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0232 0.1178 0.3149
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0099 0.0143
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0052 0.0205
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0703 0.3743 1
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2118 0.2151
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0232 0.1178 0.1197
Toxoplasma gondii DNA polymerase 0.0703 0.3743 1
Trichomonas vaginalis ap endonuclease, putative 0.0117 0.0554 0.1474
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.043 0.1148
Echinococcus multilocularis GPCR, family 2 0.0032 0.009 0.009
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0207 0.0207
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0184 0.0917 0.5741
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0616 0.1645
Loa Loa (eye worm) hypothetical protein 0.008 0.035 0.0936
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0044 0.0112
Echinococcus granulosus GPCR family 2 0.0032 0.009 0.0091
Plasmodium falciparum glutathione reductase 0.0032 0.0091 0.0243
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0207 0.0543
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0294 0.1517 0.4053
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0292 0.078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0375 0.1959 0.2814
Entamoeba histolytica hypothetical protein 0.0109 0.0508 0.1351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.0917 0.1317
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0365
Leishmania major DNA polymerase eta, putative 0.0041 0.0138 0.0367
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0024 0.0044 0.0112
Onchocerca volvulus 0.0034 0.0099 0.0257
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0129 0.0617 0.1642
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0024 0.0044 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0138 0.0753
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0422 0.1128
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0179 0.0479
Brugia malayi hypothetical protein 0.0027 0.0061 0.0163
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0024 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0067 0.0278 0.0743
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0024 0.0044 0.0119
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0044 0.0119
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Schistosoma mansoni ap endonuclease 0.0117 0.0554 0.0795
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0003 0.0003
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0133 0.035
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0093 0.0147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0091 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.0917 0.245
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0121 0.0317
Toxoplasma gondii DNA polymerase family B protein 0.0103 0.0477 0.1276
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0091 0.0243
Giardia lamblia DNA polymerase alpha subunit A 0.0103 0.0477 0.127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0025 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0069 0.0183
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0099 0.0265
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0133 0.0135
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0129 0.0131
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0024 0.0044 0.0119
Schistosoma mansoni neutral sphingomyelinase 0.0024 0.0044 0.0064
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0024 0.0044 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0025 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0425 0.0432
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0003 0.0009
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0099 0.0257
Echinococcus granulosus expressed protein 0.0016 0.0003 0.0003
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0184 0.0917 0.245
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0703 0.3743 1
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0232 0.1178 0.3144
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0138 0.0367
Trypanosoma brucei katanin, putative 0.0016 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0101 0.0466 0.1246
Brugia malayi Ets-domain containing protein 0.0078 0.034 0.0907
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0133 0.0191
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0253 0.0257
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.01 0.0046
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0049 0.0185 0.0494
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0422 0.1128
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0025 0.0026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0091 0.0092
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0179 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.001 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.0616 0.1645
Onchocerca volvulus 0.0023 0.0039 0.0094
Brugia malayi hypothetical protein 0.0016 0.0003 0.0009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.1071 0.1696
Trypanosoma brucei metalloprotease, putative 0.0016 0.0002 0.0007
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0091 0.0456
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0073 0.0315 0.0835
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0129 0.0129
Trichomonas vaginalis esterase, putative 0.0184 0.0917 0.2445
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0121 0.0317
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Mycobacterium leprae Probable lipase LipE 0.0184 0.0917 0.5533
Loa Loa (eye worm) hypothetical protein 0.0039 0.0129 0.0346
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0003 0.0005
Trypanosoma brucei katanin, putative 0.0016 0.0002 0.0007
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0003 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0099 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0133 0.035
Mycobacterium tuberculosis Putative conserved ATPase 0.0186 0.0926 0.1467
Giardia lamblia hypothetical protein 0.0024 0.0044 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0025 0.0068
Schistosoma mansoni inositol monophosphatase 0.0038 0.0121 0.0174
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0024 0.0044 0.0119
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0068 0.0069
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0025 0.0068
Mycobacterium tuberculosis Probable exported protein 0.0024 0.0044 0.007
Schistosoma mansoni ap endonuclease 0.0117 0.0554 0.0795
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0025 0.0037
Schistosoma mansoni hypothetical protein 0.1294 0.6963 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0138 0.0198
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0121 0.0323
Brugia malayi Bromodomain containing protein 0.0047 0.017 0.0454
Brugia malayi TAR-binding protein 0.0062 0.0254 0.0679
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0052 0.0205
Echinococcus granulosus vacuolar protein sorting associated protein 4A 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0184 0.0917 0.245
Schistosoma mansoni ets-related 0.0236 0.1203 0.1728
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0003 0.0005
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0232 0.1178 0.1693
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0117 0.0554 0.1474
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0091 0.0243
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0099 0.0265
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.001 0.0021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.1071 0.1696
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0091 0.0243
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.043 1
Trypanosoma cruzi vacuolar protein sorting-associated protein 4, putative 0.0016 0.0002 0.0007
Onchocerca volvulus 0.0028 0.007 0.0179
Trypanosoma cruzi katanin, putative 0.0016 0.0002 0.0007
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0003 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0613 0.1639
Leishmania major katanin, putative,serine peptidase, Clan SJ, family S16, putative 0.0016 0.0002 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0184 0.0917 0.1452
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0024 0.0044 0.0119
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.043 0.1148
Onchocerca volvulus DNA polymerase homolog 0.0232 0.1178 0.3143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0025 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0117 0.0554 0.1479
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0179 0.0479
Echinococcus multilocularis cpg binding protein 0.0032 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Leishmania major endonuclease/exonuclease protein-like protein 0.0024 0.0044 0.0119
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0309 0.0314
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0158 0.0777 0.1116
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0294 0.1517 0.2179
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0025 0.0037
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0703 0.3743 1
Echinococcus multilocularis traf and tnf receptor associated protein 0.0024 0.0044 0.0044
Echinococcus granulosus lamin 0.0081 0.0359 0.0364
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0508 0.0729
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0294 0.1517 0.4049
Brugia malayi CCR4 0.0024 0.0044 0.0119
Echinococcus multilocularis musashi 0.0081 0.0359 0.0359
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0207 0.021
Brugia malayi RNA binding protein 0.0062 0.0254 0.0679
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0703 0.3743 0.5375
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0025 0.0068
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Loa Loa (eye worm) cysteine protease 0.0034 0.0099 0.0265
Mycobacterium tuberculosis Probable esterase LipL 0.0184 0.0917 0.1452
Mycobacterium ulcerans hypothetical protein 0.0184 0.0917 0.5741
Schistosoma mansoni cpg binding protein 0.0032 0.0091 0.013
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0003 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0069 0.0183
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0253 0.04
Entamoeba histolytica G protein alpha subunit, putative 0.0016 0.0003 0.0002
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.009 0.0091
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0179 0.0472
Onchocerca volvulus 0.0184 0.0917 0.2443
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0703 0.3743 0.38
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0077 0.0206
Onchocerca volvulus 0.0034 0.0099 0.0257
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0609 0.377
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0003 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0138 0.0753
Giardia lamblia DINP protein human, muc B family 0.0041 0.0138 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0025 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0025 0.0068
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0024 0.0044 0.0119
Brugia malayi mbt repeat family protein 0.0053 0.0207 0.0552
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0003 0.0002
Trypanosoma brucei RNA editing exonuclease 2 0.0024 0.0044 0.0119
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.002 0.0028
Leishmania major cathepsin L-like protease 0.0034 0.0099 0.0265
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0024 0.0044 0.0112
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0003 0.0009
Trypanosoma cruzi ISWI complex protein 0.0017 0.0009 0.0024
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.043 0.1148
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0117 0.0554 0.0554
Leishmania major cathepsin L-like protease 0.0034 0.0099 0.0265
Schistosoma mansoni cpg binding protein 0.0032 0.0091 0.013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0119
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0025 0.0037
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0025 0.0037
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0103 0.0477 0.127
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0024 0.0044 0.0119
Brugia malayi cathepsin L-like precursor 0.0023 0.0039 0.0103
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0003 0.0002
Brugia malayi acetyltransferase, GNAT family protein 0.0158 0.0777 0.2077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0091 0.0243
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0081 0.0359 0.0958
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0133 0.0133
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0146 0.0709 0.1895
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0099 0.0099
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0052 0.0132
Schistosoma mansoni hypothetical protein 0.0032 0.009 0.0129
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0135 0.0135
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0232 0.1178 0.1693
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0003 0.0005
Loa Loa (eye worm) fibroinase 0.0034 0.0099 0.0265
Echinococcus granulosus cathepsin l1 0.0034 0.0099 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Schistosoma mansoni thyroid hormone receptor 0.002 0.0025 0.0037
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0091 0.0243
Brugia malayi valosin containing protein 0.0182 0.0906 0.242
Loa Loa (eye worm) MBCTL1 0.0061 0.0247 0.0659
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.1071 0.1696
Leishmania major cathepsin L-like protease 0.0034 0.0099 0.0265
Trypanosoma brucei cytochrome P450, putative 0.0019 0.002 0.0053
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0025 0.0025
Brugia malayi Bromodomain containing protein 0.0089 0.0403 0.1076
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Schistosoma mansoni coup transcription factor 0.002 0.0025 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0061 0.0163
Echinococcus multilocularis muscleblind protein 0.0146 0.0709 0.0709
Brugia malayi DNA polymerase family B containing protein 0.0232 0.1178 0.3149
Loa Loa (eye worm) glutathione reductase 0.0093 0.0422 0.1128
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0112
Leishmania major hypothetical protein, conserved 0.0184 0.0917 0.245
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0133 0.0356
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Trypanosoma cruzi mitochondrial protein 99, putative 0.0024 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.004 0.0133 0.0356
Entamoeba histolytica hypothetical protein 0.0109 0.0508 0.1351
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0044 0.0119
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0091 0.0243
Plasmodium vivax vivapain-1 0.0017 0.001 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Brugia malayi hypothetical protein 0.0109 0.0508 0.1357
Echinococcus multilocularis vacuolar protein sorting associated protein 4A 0.0016 0.0002 0.0002
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0232 0.1178 0.3149
Brugia malayi steroid hormone receptor 0.002 0.0025 0.0068
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0232 0.1178 0.3149
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0099 0.0101
Trypanosoma brucei vesicular transport protein (CDC48 homologue), putative 0.0016 0.0002 0.0007
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0133 0.035
Brugia malayi Cathepsin L-like precursor 0.0034 0.0099 0.0265
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0138 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0077 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0077 0.0111
Leishmania major hypothetical protein, conserved 0.0027 0.0061 0.0163
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.1071 0.6567
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.001 0.0027
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0121 0.0317
Brugia malayi Cytochrome P450 family protein 0.0048 0.0178 0.0476
Giardia lamblia AAA family ATPase 0.0186 0.0926 0.2469
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0091 0.0144
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0025 0.0068
Mycobacterium ulcerans hypothetical protein 0.0025 0.0052 0.0205
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0232 0.1178 0.3149
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0348 0.1813 0.2604
Echinococcus multilocularis katanin p60 ATPase containing subunit A1 0.0016 0.0002 0.0002
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0121 0.0121
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0099 0.0257
Loa Loa (eye worm) hypothetical protein 0.0184 0.0917 0.245
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0477 0.127
Entamoeba histolytica cysteine proteinase 2 0.0017 0.001 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.009 0.009
Echinococcus multilocularis lamin dm0 0.0081 0.0359 0.0359
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0207 0.021
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0232 0.1178 0.3149
Echinococcus granulosus muscleblind protein 0.0146 0.0709 0.072
Onchocerca volvulus 0.0184 0.0917 0.2443
Schistosoma mansoni cpg binding protein 0.0028 0.007 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0025 0.0068
Brugia malayi Pre-SET motif family protein 0.003 0.0077 0.0206
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0003 0.0009
Toxoplasma gondii hypothetical protein 0.0033 0.0093 0.0248
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0003 0.0005
Trypanosoma brucei Valosin-containing protein 0.0294 0.1517 0.4053
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0024 0.0044 0.0112
Loa Loa (eye worm) ctsf protein 0.0034 0.0099 0.0265
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0163
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0117 0.0554 0.1474
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.001 0.0027
Plasmodium vivax cell division cycle ATPase, putative 0.0112 0.0527 0.1408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Schistosoma mansoni hypothetical protein 0.0032 0.009 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0025 0.0068
Plasmodium vivax vivapain-3 0.0017 0.001 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.0917 0.245
Trypanosoma cruzi cysteine protease, putative 0.0017 0.001 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Schistosoma mansoni hypothetical protein 0.0404 0.2118 0.3042
Brugia malayi SAP1 protein 0.0016 0.0002 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0025 0.0068
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0024 0.0044 0.0119
Echinococcus granulosus cathepsin L 0.0017 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0109 0.0508 0.0729
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0103
Mycobacterium tuberculosis Probable oxidoreductase 0.0236 0.12 0.1901
Brugia malayi Latrophilin receptor protein 2 0.0032 0.009 0.024
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0062 0.0089
Onchocerca volvulus 0.0034 0.0099 0.0257
Brugia malayi Cathepsin L-like precursor 0.0034 0.0099 0.0265
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.043 0.0436
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0024 0.0044 0.0112
Trypanosoma cruzi katanin, putative 0.0016 0.0002 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0024 0.0044 0.0112
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.043 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0003 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0117 0.0554 0.1479
Echinococcus granulosus lamin dm0 0.0081 0.0359 0.0364
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.01 0.0158
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0039 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Brugia malayi hypothetical protein 0.0017 0.0009 0.0025
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0232 0.1178 0.1197
Onchocerca volvulus 0.0034 0.0099 0.0257
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0129 0.0617 0.1647
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0103
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0099 0.0265
Entamoeba histolytica cysteine protease, putative 0.0017 0.001 0.0021
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0703 0.3743 1
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0003 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0025 0.0068
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0117 0.0554 0.1479
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0024 0.0044 0.0119
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0508 0.0508
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0024 0.0044 0.0045
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0025 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Schistosoma mansoni nuclear hormone receptor 0.002 0.0025 0.0037
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0133 0.0133
Onchocerca volvulus 0.0049 0.018 0.0472
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.043 0.2263
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0061 0.0163
Schistosoma mansoni carbon catabolite repressor protein 0.0024 0.0044 0.0064
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0003 0.0002
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0003 0.0009
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0052 0.0139
Brugia malayi intermediate filament protein 0.0081 0.0359 0.0958
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.1071 0.1696
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0178 0.0476
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0222 0.1295
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0025 0.0059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.007 0.0188
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0024 0.0044 0.0112
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0153 0.0408
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0184 0.0917 0.245
Brugia malayi PHD-finger family protein 0.0033 0.0097 0.0259
Leishmania major hypothetical protein, conserved 0.0024 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0089 0.0402 0.1073
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.1099 0.2937
Loa Loa (eye worm) fidgetin protein 0.0016 0.0002 0.0007
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0039 0.0097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0025 0.0026
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0232 0.1178 0.3149
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0068
Mycobacterium tuberculosis Conserved protein 0.0025 0.0052 0.0082
Schistosoma mansoni gabp alpha 0.0078 0.034 0.0488
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0247 0.0354
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0247 0.0659
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0091 0.0243
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0249 0.0358
Echinococcus multilocularis expressed protein 0.0016 0.0003 0.0003
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.002 0.002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.0609 0.0618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0616 0.1645
Loa Loa (eye worm) CYP4Cod1 0.0019 0.002 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.002 0.0053
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0232 0.1178 0.1178
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0222 0.1295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Loa Loa (eye worm) hypothetical protein 0.0089 0.0402 0.1073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0099 0.0259
Loa Loa (eye worm) hypothetical protein 0.0182 0.0906 0.242
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0052 0.0205
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.0917 0.2445
Echinococcus granulosus beta LACTamase domain containing family member 0.0184 0.0917 0.0931
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0024 0.0044 0.0119
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0138 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0025 0.0068
Giardia lamblia Fructose-bisphosphate aldolase 0.0627 0.3328 0.8891
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0222 0.0594
Loa Loa (eye worm) hypothetical protein 0.0043 0.015 0.04
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0117 0.0554 0.0877
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0359 0.0958
Onchocerca volvulus 0.0184 0.0917 0.2443
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0025 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0138 0.0367
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.0917 0.1317
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.001 0.0027
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0207 0.0552
Loa Loa (eye worm) vps4b-prov protein 0.0016 0.0002 0.0007
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.043 0.7322
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0099 0.0259
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0024 0.0044 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0133 0.035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0375 0.1959 0.1989
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Echinococcus granulosus fidgetin protein 1 0.0016 0.0002 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0099 0.0259
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0025 0.0068
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0128 0.0614 0.0614
Echinococcus multilocularis synaptojanin 1 0.0024 0.0044 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0466 0.1246
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0138 0.0361
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.043 0.1148
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0003 0.0003
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0222 0.0594
Echinococcus multilocularis zinc finger protein 0.0027 0.0065 0.0065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0627 0.3328 0.8891
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.1099 0.2937
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0375 0.1959 0.1989
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0247 0.0247
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0091 0.0243
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0508 0.0516
Trypanosoma brucei unspecified product 0.0028 0.0069 0.0183
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0091 0.0456

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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