Detailed information for compound 1403324

Basic information

Technical information
  • TDR Targets ID: 1403324
  • Name: N-[[2-methyl-5-(3-methyl-4-oxophthalazin-1-yl )phenyl]methyl]butanamide
  • MW: 349.426 | Formula: C21H23N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)NCc1cc(ccc1C)c1nn(C)c(=O)c2c1cccc2
  • InChi: 1S/C21H23N3O2/c1-4-7-19(25)22-13-16-12-15(11-10-14(16)2)20-17-8-5-6-9-18(17)21(26)24(3)23-20/h5-6,8-12H,4,7,13H2,1-3H3,(H,22,25)
  • InChiKey: GOQMEBUJBUGIEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[2-methyl-5-(3-methyl-4-oxo-phthalazin-1-yl)phenyl]methyl]butanamide
  • N-[[2-methyl-5-(3-methyl-4-oxo-1-phthalazinyl)phenyl]methyl]butanamide
  • N-[5-(4-keto-3-methyl-phthalazin-1-yl)-2-methyl-benzyl]butyramide
  • ZINC00204037
  • MLS000556874
  • SMR000147991
  • STK238619
  • BAS 06574917
  • N-[2-Methyl-5-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-benzyl]-butyramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0047 0.0076
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0733 0.2989 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0019 0.0048 0.011
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0048 0.0869
Trypanosoma brucei sugar transporter, putative 0.0018 0.0047 0.1013
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0048 0.0869
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0065 0.0167
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0047 0.0076
Leishmania major cytochrome p450-like protein 0.0013 0.0025 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0047 0.0076
Schistosoma mansoni DNA helicase recq5 0.0009 0.001 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0034 0.0113 1
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0047 0.0834
Onchocerca volvulus 0.0018 0.0047 0.0003
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0019 0.0048 0.011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.000000000032071 0.00000000005216
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0019 0.0048 0.0038
Mycobacterium ulcerans sugar transporter 0.0018 0.0047 0.0105
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.0048 0.0008
Onchocerca volvulus 0.0256 0.1025 0.3346
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0444 0.044
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Schistosoma mansoni sugar transporter 0.0018 0.0047 0.0043
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0048 0.1047
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0048 0.0869
Brugia malayi oxidoreductase 0.0019 0.0048 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0047 0.0076
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0018 0.0047 0.0037
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0047 0.0105
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Echinococcus granulosus solute carrier family 22 0.0018 0.0047 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Onchocerca volvulus 0.0122 0.0474 0.1463
Schistosoma mansoni glutaminase 0.0217 0.0863 0.086
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0019 0.0048 0.1047
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0176
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0065 0.2796
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0099 0.0161
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0444 0.521
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0048 0.0078
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0048 0.0453
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0011 0.0016 0.0006
Entamoeba histolytica hypothetical protein 0.0034 0.0113 0.0159
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0056 0.0052
Trypanosoma brucei THT1 - hexose transporter, putative 0.0018 0.0047 0.1013
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0017 0.0013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0064 0.0105
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.15 0.6149 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000032071 0.00000000005216
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0019 0.0048 0.0045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.15 0.6149 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0011 0.0016 0.0115
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0036 0.0121 0.1326
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Onchocerca volvulus 0.0018 0.0047 0.0003
Leishmania major dehydrogenase-like protein 0.0019 0.0048 0.0453
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0046 0.0795
Brugia malayi Kringle domain containing protein 0.0018 0.0046 0.0138
Trypanosoma brucei protein kinase, putative 0.0054 0.0193 0.4324
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0048 0.0078
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.046 0.1495
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0045 0.0041
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0019 0.0048 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000032071 0.00000000005216
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0048 0.0869
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0047 0.0076
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0211 0.0842 0.0839
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0048 0.0869
Brugia malayi CXXC zinc finger family protein 0.003 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0276 0.1109 0.423
Toxoplasma gondii sugar transporter ST1 0.0018 0.0047 0.0816
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0047 0.0037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0276 0.1109 0.1106
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0193 0.4211
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0048 0.0038
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0444 0.144
Onchocerca volvulus 0.0019 0.0048 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0352 0.0349
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.046 0.0451
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0048 0.0869
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0025 0.0059
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Onchocerca volvulus 0.0019 0.0048 0.0008
Schistosoma mansoni carbonyl reductase 0.0019 0.0048 0.0045
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0019 0.0048 0.0849
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Onchocerca volvulus 0.0018 0.0047 0.0003
Brugia malayi Trypsin family protein 0.002 0.0056 0.0175
Toxoplasma gondii carbonyl reductase 1, putative 0.0019 0.0048 0.0849
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0444 0.0698
Treponema pallidum fructose-bisphosphate aldolase 0.15 0.6149 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Onchocerca volvulus 0.002 0.0056 0.0033
Toxoplasma gondii oxidoreductase, putative 0.0019 0.0048 0.0849
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Echinococcus multilocularis solute carrier family 22 0.0018 0.0047 0.0037
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0021 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0048 0.0869
Giardia lamblia Fructose-bisphosphate aldolase 0.15 0.6149 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0034 0.0113 0.2287
Trypanosoma cruzi hexose transporter 0.0018 0.0047 0.0834
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000032071 0.00000000005216
Giardia lamblia DINP protein human, muc B family 0.0011 0.0016 0.0009
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.0048 0.011
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0046 0.0358
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0138
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0048 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.046 0.5408
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0034 0.0113 0.0327
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.046 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0048 0.1047
Schistosoma mansoni carbonyl reductase 0.0019 0.0048 0.0045
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0019 0.0048 0.0045
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0099 0.867
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0048 0.011
Schistosoma mansoni sugar transporter 0.0018 0.0047 0.0043
Trypanosoma brucei unspecified product 0.0011 0.0016 0.0308
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0099 0.0161
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0099 0.0161
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.0048 0.011
Entamoeba histolytica short chain dehydrogenase family protein 0.0019 0.0048 0.0053
Brugia malayi 6-phosphofructokinase 0.0115 0.0444 0.167
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0444 0.167
Loa Loa (eye worm) hypothetical protein 0.0276 0.1109 0.423
Trypanosoma cruzi DNA polymerase eta, putative 0.0011 0.0016 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.15 0.6149 1
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.002 0.0056 0.0046
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0444 0.167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0011 0.0016 0.0012
Mycobacterium ulcerans dehydrogenase 0.0019 0.0048 0.011
Onchocerca volvulus 0.0019 0.0048 0.0008
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0193 0.0298
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0176
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0032 0.0084
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0048 0.0869
Schistosoma mansoni cpg binding protein 0.003 0.0096 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Brugia malayi phosphofructokinase 0.0115 0.0444 0.167
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0113 0.022
Brugia malayi Sugar transporter family protein 0.0018 0.0047 0.0141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0444 0.0622
Echinococcus granulosus geminin 0.0171 0.0675 0.0666
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0065 0.0971
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0019 0.0048 0.011
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0193 0.0183
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.002 0.0056 0.0046
Echinococcus granulosus transmembrane protease serine 3 0.002 0.0056 0.0046
Echinococcus multilocularis solute carrier family 22 0.0018 0.0047 0.0037
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0048 0.0053
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0277
Toxoplasma gondii facilitative glucose transporter GT1 0.0018 0.0047 0.0816
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Onchocerca volvulus 0.0027 0.0084 0.013
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0099 0.0136
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Echinococcus granulosus solute carrier family 22 0.0018 0.0047 0.0037
Brugia malayi 6-phosphofructokinase 0.0115 0.0444 0.167
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0099 0.1983
Onchocerca volvulus 0.0018 0.0047 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0222 0.4707
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0047 0.0105
Echinococcus granulosus glycoprotein Antigen 5 0.002 0.0056 0.0046
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0036 0.0121 0.2546
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0025 0.0059
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0048 0.0053
Toxoplasma gondii sugar transporter ST3 0.0018 0.0047 0.0816
Leishmania major hypothetical protein, conserved 0.0018 0.0047 0.0435
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0048 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0193 0.0314
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0047 0.0043
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0019 0.0048 0.011
Echinococcus granulosus lamin dm0 0.0027 0.0084 0.0074
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0193 0.2194
Leishmania major oxidoreductase-like protein 0.0019 0.0048 0.0453
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0056 0.0052
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0099 0.2041
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0024 0.0053
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0065 0.0167
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.046 0.1495
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0047 0.0037
Onchocerca volvulus 0.0019 0.0048 0.0008
Echinococcus granulosus cpg binding protein 0.0032 0.0104 0.0094
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0444 0.0722
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0021 0.0436
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0211 0.0842 0.2779
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0099 0.1983
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0019 0.0048 0.1047
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0444 0.144
Onchocerca volvulus 0.0729 0.2972 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.000000000032071 0.00000000005216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.15 0.6149 1
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0444 0.0434
Loa Loa (eye worm) hypothetical protein 0.0092 0.0352 0.1318
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0046 0.0812
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0048 0.0453
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0036 0.0121 0.0428
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0193 0.0183
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0211 0.0842 0.2779
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0019 0.0048 0.0849
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0849
Onchocerca volvulus 0.0027 0.0084 0.013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0065 0.1261
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0019 0.0048 0.0053
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0211 0.0842 0.0833
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0193 0.0314
Trypanosoma brucei THT1 - hexose transporter, putative 0.0018 0.0047 0.1013
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.0048 0.011
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Brugia malayi follicle stimulating hormone receptor 0.0127 0.0494 0.1863
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0084 0.0284
Trypanosoma brucei glucose transporter, putative 0.0018 0.0047 0.1013
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0048 0.011
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0026 0.0016
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0444 0.0698
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Echinococcus granulosus Solute carrier family 22 5 0.1631 0.6687 0.6684
Brugia malayi hypothetical protein 0.0018 0.0047 0.0141
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Echinococcus granulosus hypothetical protein 0.0019 0.0048 0.0038
Brugia malayi Cytochrome P450 family protein 0.0013 0.0025 0.0058
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0047 0.0816
Echinococcus multilocularis transmembrane protease serine 3 0.002 0.0056 0.0046
Mycobacterium ulcerans dehydrogenase/reductase 0.0019 0.0048 0.011
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0034 0.0113 0.2472
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0019 0.0048 0.0147
Onchocerca volvulus 0.0276 0.1109 0.3633
Onchocerca volvulus 0.0018 0.0047 0.0003
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0021 0.0009
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0019 0.0048 0.0062
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0193 0.4065
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0176
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0065 0.0106
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0048 0.0869
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Echinococcus granulosus oxidoreductase 0.0019 0.0048 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0065 0.0657
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0036 0.0121 0.0111
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Leishmania major 3-keto-dihydrosphingosine reductase 0.0019 0.0048 0.0453
Trypanosoma brucei DNA polymerase IV, putative 0.0011 0.0016 0.0308
Brugia malayi Dehydrogenases, short chain protein 30 0.0019 0.0048 0.0147
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0048 0.0038
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0062
Onchocerca volvulus 0.0018 0.0047 0.0003
Mycobacterium ulcerans glutaminase 0.0217 0.0863 0.2851
Echinococcus multilocularis solute carrier family 22 0.0018 0.0047 0.0037
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0048 0.3715
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Brugia malayi Trypsin family protein 0.002 0.0056 0.0175
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0064 0.0054
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0017 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.15 0.6149 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0065 0.0213
Brugia malayi Protein kinase domain containing protein 0.0018 0.0046 0.0138
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0011 0.0016 0.0006
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0019 0.0048 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000032071 0.00000000005216
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Schistosoma mansoni hypothetical protein 0.002 0.0056 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0048 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0047 0.0141
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.0048 0.011
Echinococcus granulosus WW domain containing oxidoreductase 0.0019 0.0048 0.0038
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0019 0.0048 0.011
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Trypanosoma brucei glucose transporter, putative 0.0018 0.0047 0.1013
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Schistosoma mansoni hypothetical protein 0.0018 0.0046 0.0042
Onchocerca volvulus 0.0019 0.0048 0.0008
Echinococcus multilocularis oxidoreductase 0.0019 0.0048 0.0038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0048 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0011 0.0016 0.0115
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Brugia malayi dehydrogenases, short chain protein 9 0.0019 0.0048 0.0147
Onchocerca volvulus 0.0018 0.0047 0.0003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0065 0.5368
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0048 0.0053
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0019 0.0048 0.011
Echinococcus multilocularis geminin 0.0171 0.0675 0.0666
Loa Loa (eye worm) glutaminase 2 0.0217 0.0863 0.3285
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0048 0.0453
Onchocerca volvulus 0.0092 0.0352 0.1047
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0193 0.4211
Brugia malayi Pre-SET motif family protein 0.0092 0.0352 0.1317
Brugia malayi Cytochrome P450 family protein 0.0013 0.0025 0.0058
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0193 0.4324
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0018 0.0047 0.0037
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0025 0.0524
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0047 0.0105
Trichomonas vaginalis steroid dehydrogenase, putative 0.0019 0.0048 0.0078
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.046 0.0457
Onchocerca volvulus Putative transporter 0.0018 0.0047 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Schistosoma mansoni glucose transport protein 0.0018 0.0047 0.0043
Loa Loa (eye worm) dehydrogenase 0.0019 0.0048 0.0148
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0048 0.0436
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0444 1
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0047 0.0834
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.15 0.6149 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0122 0.0474 0.0464
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Leishmania major glucose transporter, lmgt2 0.0018 0.0047 0.0435
Onchocerca volvulus 0.002 0.0056 0.0033
Onchocerca volvulus 0.0019 0.0048 0.0008
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0019 0.0048 0.0045
Mycobacterium tuberculosis Probable dehydrogenase 0.0019 0.0048 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0047 0.0076
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0048 0.0869
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0733 0.2989 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.002 0.0056 0.0046
Echinococcus granulosus transcription factor Dp 1 0.0021 0.0058 0.0048
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0084 0.0284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0034 0.0526
Leishmania major DNA polymerase eta, putative 0.0011 0.0016 0.006
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0047 0.0076
Mycobacterium ulcerans oxidoreductase 0.0019 0.0048 0.011
Schistosoma mansoni sugar transporter 0.0018 0.0047 0.0043
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0733 0.2989 1
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0047 0.0141
Brugia malayi hypothetical protein 0.002 0.0056 0.0175
Schistosoma mansoni hypothetical protein 0.0171 0.0675 0.0672
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0193 0.0183
Trichomonas vaginalis set domain proteins, putative 0.0729 0.2972 0.4833
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0017 0.0007
Brugia malayi hypothetical protein 0.0019 0.0048 0.0147
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0053 0.4192
Schistosoma mansoni glucose transport protein 0.0018 0.0047 0.0043
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Giardia lamblia Short-chain dehydrogenase, putative 0.0019 0.0048 0.0062
Trypanosoma brucei glucose transporter, putative 0.0018 0.0047 0.1013
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0019 0.0048 0.011
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0048 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0193 0.019
Trypanosoma brucei DNA polymerase IV, putative 0.0011 0.0016 0.0308
Loa Loa (eye worm) POT family protein 0.0082 0.031 0.1157
Echinococcus granulosus hypothetical protein 0.0019 0.0048 0.0038
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0018 0.0047 0.0037
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0099 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0048 0.0869
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0176
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000032071 0.00000000005216
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0444 0.0698
Trypanosoma brucei glucose transporter, putative 0.0018 0.0047 0.1013
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0048 0.1047
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0034 0.0113 0.0327
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.000000000032071 0.00000000005216
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0048 0.1047
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0444 0.0434
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0047 0.0142
Toxoplasma gondii sugar transporter ST2 0.0018 0.0047 0.0816
Brugia malayi Trypsin family protein 0.0276 0.1109 0.4229
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Onchocerca volvulus 0.002 0.0056 0.0033
Trypanosoma brucei DNA polymerase eta, putative 0.0011 0.0016 0.0308
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0047 0.0076
Leishmania major short chain dehydrogenase, putative 0.0019 0.0048 0.0453
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.046 0.0451
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0026 0.0016
Echinococcus multilocularis cpg binding protein 0.0032 0.0104 0.0094
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0176
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0113 0.2512
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Leishmania major pteridine reductase 1 0.0019 0.0048 0.0453
Schistosoma mansoni hypothetical protein 0.0171 0.0675 0.0672
Onchocerca volvulus 0.0019 0.0048 0.0008
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0048 0.0453
Trypanosoma cruzi DNA polymerase kappa, putative 0.0011 0.0016 0.0115
Echinococcus multilocularis dna polymerase kappa 0.0011 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0034 0.0113 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0046 0.3475
Onchocerca volvulus 0.002 0.0056 0.0033
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0047 0.0834
Brugia malayi Trypsin-like protease protein 5 0.002 0.0056 0.0175
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0065 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Brugia malayi Sugar transporter family protein 0.0018 0.0047 0.0141
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0444 0.0722
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0849
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0849
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0047 0.0076
Entamoeba histolytica short chain dehydrogenase family protein 0.0019 0.0048 0.0053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.002 0.0056 0.0052
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0024 0.0014
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0048 0.011
Schistosoma mansoni sugar transporter 0.0018 0.0047 0.0043
Loa Loa (eye worm) sugar transporter 0.0018 0.0047 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.15 0.6149 1
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0036 0.0121 0.0427
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0019 0.0048 0.011
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0048 0.0869
Trypanosoma cruzi DNA polymerase kappa, putative 0.0011 0.0016 0.0115
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0019 0.0048 0.011
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0046 0.0138
Schistosoma mansoni cpg binding protein 0.0032 0.0104 0.01
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0048 0.0038
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0025 0.0336
Leishmania major glucose transporter/membrane transporter D2, putative 0.0018 0.0047 0.0435
Schistosoma mansoni retinal dehydrogenase 0.0019 0.0048 0.0045
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0019 0.0048 0.1047
Schistosoma mansoni DNA polymerase eta 0.0011 0.0016 0.0012
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0034 0.0113 0.2287
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0046 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Leishmania major short chain dehydrogenase-like protein 0.0019 0.0048 0.0453
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0064 0.0209
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0193 0.4211
Trypanosoma brucei glucose transporter, putative 0.0018 0.0047 0.1013
Loa Loa (eye worm) RecQ helicase 0.0023 0.0064 0.021
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Schistosoma mansoni DNA helicase recq1 0.0009 0.001 0.0006
Schistosoma mansoni carbonyl reductase 0.0019 0.0048 0.0045
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0018 0.0047 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.064 0.2608 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0018 0.0047 0.1013
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0047 0.3569
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0019 0.0048 0.0008
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0019 0.0048 0.011
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0021 0.0128
Trypanosoma brucei DNA polymerase IV, putative 0.0011 0.0016 0.0308
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0211 0.0842 0.2779
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0048 0.011
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0048 0.011
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0048 0.0078
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0047 0.0105
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.002 0.0056 0.0175
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0138
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0099 0.0161
Echinococcus multilocularis musashi 0.0027 0.0084 0.0074
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0193 0.0183
Brugia malayi Trypsin family protein 0.002 0.0056 0.0175
Mycobacterium ulcerans short-chain type oxidoreductase 0.0019 0.0048 0.011
Mycobacterium ulcerans carveol-like dehydrogenase 0.0019 0.0048 0.011
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Echinococcus granulosus lamin 0.0027 0.0084 0.0074
Onchocerca volvulus 0.0018 0.0047 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Echinococcus multilocularis lamin 0.0027 0.0084 0.0074
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0099 0.0161
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0018 0.0047 0.0037
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0099 0.867
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Loa Loa (eye worm) glutaminase 0.0217 0.0863 0.3285
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0048 0.0453
Onchocerca volvulus 0.0018 0.0047 0.0003
Brugia malayi hypothetical protein 0.0018 0.0047 0.0141
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.0048 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0849
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0065 0.0055
Onchocerca volvulus 0.0019 0.0048 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0352 0.0343
Leishmania major hypothetical protein, conserved 0.0019 0.0048 0.0453
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0047 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0047 0.0076
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Plasmodium vivax sugar transporter, putative 0.0018 0.0047 0.0388
Leishmania major glucose transporter, lmgt3 0.0018 0.0047 0.0435
Loa Loa (eye worm) sugar transporter 0.0018 0.0047 0.0142
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0048 0.0038
Echinococcus multilocularis conserved hypothetical protein 0.0019 0.0048 0.0038
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0048 0.011
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0018 0.0047 0.0037
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0025 0.0059
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0019 0.0048 0.0038
Trichomonas vaginalis DNA polymerase eta, putative 0.0011 0.0016 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Brugia malayi glutaminase DH11.1 0.0217 0.0863 0.3285
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0021 0.0245
Echinococcus multilocularis dna polymerase eta 0.0011 0.0016 0.0006
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0048 0.0453
Schistosoma mansoni cpg binding protein 0.0032 0.0104 0.01
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0048 0.0038
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0099 0.0161
Brugia malayi major facilitator superfamily protein 0.0018 0.0047 0.0141
Onchocerca volvulus 0.0018 0.0047 0.0003
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0019 0.0048 0.0148
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0046 0.0036
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0048 0.0453
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Brugia malayi MAP kinase sur-1 0.0054 0.0193 0.0704
Brugia malayi ImpB/MucB/SamB family protein 0.0011 0.0016 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Mycobacterium ulcerans oxidoreductase 0.0019 0.0048 0.011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.001 0.00000000038691
Schistosoma mansoni ap endonuclease 0.0023 0.0065 0.0062
Plasmodium vivax SET domain protein, putative 0.0092 0.0352 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0193 0.0314
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0056 0.0052
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0211 0.0842 0.0833
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0336 0.0326
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0024 0.0014
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0036 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.0122 0.0474 0.1786
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0211 0.0842 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0193 0.0705
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0048 0.0078
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0047 0.0834
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0048 0.0038
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0444 1
Schistosoma mansoni glucose transport protein 0.0018 0.0047 0.0043
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0122 0.0474 0.047
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Onchocerca volvulus 0.0019 0.0048 0.0008
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0019 0.0048 0.1047
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0011 0.0016 0.006
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0019 0.0048 0.0038
Echinococcus multilocularis glycoprotein Antigen 5 0.002 0.0056 0.0046
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0019 0.0048 0.0038
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0048 0.0053
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0444 0.044
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0048 0.0038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Schistosoma mansoni glucose transporter 0.0018 0.0047 0.0043
Onchocerca volvulus 0.0019 0.0048 0.0008
Trypanosoma brucei oxidoreductase-like protein 0.0019 0.0048 0.1047
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0047 0.0076
Schistosoma mansoni terminal deoxycytidyl transferase 0.0011 0.0016 0.0012
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.001 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0011 0.0016 0.0022
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0048 0.0869
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Schistosoma mansoni hypothetical protein 0.002 0.0056 0.0052
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0019 0.0048 0.0078
Leishmania major hypothetical protein, conserved 0.0019 0.0048 0.0453
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0019 0.0048 0.0849
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Echinococcus multilocularis lamin dm0 0.0027 0.0084 0.0074
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0099 0.1983
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0048 0.0869
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0064 0.0105
Echinococcus multilocularis enteropeptidase 0.002 0.0056 0.0046
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0048 0.011
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Onchocerca volvulus 0.002 0.0056 0.0033
Brugia malayi dehydrogenases, short chain protein 2 0.0019 0.0048 0.0147
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0019 0.0048 0.0147
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0048 0.011
Onchocerca volvulus 0.0018 0.0047 0.0003
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0047 0.0142
Onchocerca volvulus 0.003 0.0096 0.0173
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0048 0.0038
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0011 0.0016 0.0025
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Schistosoma mansoni intermediate filament proteins 0.0027 0.0084 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0048 0.0869
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0276 0.1109 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0099 0.0161
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0352 0.7601
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0065 0.1432
Brugia malayi Sugar transporter family protein 0.0018 0.0047 0.0141
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0056 0.0052
Echinococcus multilocularis Mastin 0.002 0.0056 0.0046
Loa Loa (eye worm) dehydrogenase 0.0019 0.0048 0.0148
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0444 0.0722
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0034 0.0113 0.0327
Leishmania major glucose transporter, lmgt1 0.0018 0.0047 0.0435
Echinococcus multilocularis retinol dehydrogenase 13 0.0019 0.0048 0.0038
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0048 0.0038
Plasmodium vivax hexose transporter 0.0018 0.0047 0.0388
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0032 0.0084
Trypanosoma brucei glucose transporter, putative 0.0018 0.0047 0.1013
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0024 0.0056
Plasmodium falciparum steroid dehydrogenase, putative 0.0019 0.0048 0.3715
Leishmania major hypothetical protein, conserved 0.0019 0.0048 0.0453
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0048 0.0869
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0065 0.0106
Echinococcus granulosus intermediate filament protein 0.0027 0.0084 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0352 0.0349
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0048 0.0078
Brugia malayi Pre-SET motif family protein 0.064 0.2608 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0019 0.0048 0.0226
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0048 0.0453
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0022
Trypanosoma brucei glucose transporter 1E 0.0018 0.0047 0.1013
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0019 0.0048 0.0053
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0047 0.1013
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0084 0.0284
Brugia malayi intermediate filament protein 0.0027 0.0084 0.0284
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0019 0.0048 0.011
Onchocerca volvulus 0.0018 0.0047 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0065 0.1261
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0019 0.0048 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Onchocerca volvulus 0.0018 0.0047 0.0003
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0048 0.0078
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0193 0.2194
Schistosoma mansoni lamin 0.0027 0.0084 0.008
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0048 0.0038
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0036 0.0121 0.0172
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0099 0.0056
Echinococcus granulosus bloom syndrome protein 0.0023 0.0064 0.0054
Onchocerca volvulus 0.0018 0.0047 0.0003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0127 0.0494 0.1864
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0065 0.0081
Plasmodium falciparum hexose transporter 0.0018 0.0047 0.3569
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0047 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Giardia lamblia Hexose transporter 0.0018 0.0047 0.006
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0034 0.0113 1
Mycobacterium ulcerans hypothetical protein 0.002 0.0056 0.0134
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0056 0.0052
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0048 0.0869
Loa Loa (eye worm) trypsin family protein 0.002 0.0056 0.0176
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0036 0.0121 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.025 0.0247
Echinococcus granulosus solute carrier family 22 0.0018 0.0047 0.0037
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0193 0.4211
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0048 0.0038
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0025 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Toxoplasma gondii exonuclease III APE 0.0023 0.0065 0.1227
Giardia lamblia Reductase, putative 0.0019 0.0048 0.0062
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0047 0.0105
Echinococcus multilocularis solute carrier family 22 0.0018 0.0047 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Brugia malayi Dehydrogenases, short chain protein 2 0.0019 0.0048 0.0147
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0048 0.0869
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0018 0.0047 0.0037
Toxoplasma gondii oxidoreductase, putative 0.0019 0.0048 0.0849
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0036 0.0121 0.2546
Onchocerca volvulus 0.0019 0.0048 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Echinococcus granulosus enteropeptidase 0.002 0.0056 0.0046
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0048 0.0453
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Onchocerca volvulus 0.0018 0.0047 0.0003
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0048 0.0038
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0444 0.167
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0193 0.0765 0.2908
Brugia malayi ImpB/MucB/SamB family protein 0.0011 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0025 0.0032
Giardia lamblia Hypothetical protein 0.0019 0.0048 0.0062
Loa Loa (eye worm) oxidoreductase 0.0019 0.0048 0.0148
Echinococcus multilocularis transcription factor Dp 1 0.0021 0.0058 0.0048
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0352 0.0343
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Onchocerca volvulus 0.0018 0.0047 0.0003
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0048 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.0352 0.0349
Leishmania major hypothetical protein, conserved 0.0019 0.0048 0.0453
Echinococcus granulosus steroid dehydrogenase 0.0019 0.0048 0.0038
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0849
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0017 0.0007
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0019 0.0048 0.011
Brugia malayi Retinol dehydrogenase 12 0.0019 0.0048 0.0147
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Trichomonas vaginalis glutaminase, putative 0.0217 0.0863 0.1404
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0065 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.15 0.6149 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0048 0.0078
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0047 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0016 0.0308
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.046 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0122 0.0474 0.1785
Onchocerca volvulus 0.0019 0.0048 0.0008
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0211 0.0842 0.3202
Echinococcus granulosus Mastin 0.002 0.0056 0.0046
Onchocerca volvulus 0.0019 0.0048 0.0008
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.002 0.0056 0.0046
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0444 0.0722
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0048 0.011
Plasmodium vivax steroid dehydrogenase, putative 0.0019 0.0048 0.0436
Echinococcus granulosus dna polymerase eta 0.0011 0.0016 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.15 0.6149 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0048 0.0869
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0034 0.0113 0.0078
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0047 0.0037
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0047 0.0141
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0048 0.0869
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0048 0.011
Leishmania major hypothetical protein, conserved 0.0019 0.0048 0.0453
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0048 0.011
Leishmania major short chain dehydrogenase, putative 0.0019 0.0048 0.0453
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0054
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0019 0.0048 0.1047
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0019 0.0048 0.011
Brugia malayi hypothetical protein 0.0019 0.0048 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Schistosoma mansoni ap endonuclease 0.0023 0.0065 0.0062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0352 0.0343
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0065 0.0213
Schistosoma mansoni lamin 0.0027 0.0084 0.008
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trypanosoma brucei glucose transporter 2A 0.0018 0.0047 0.1013
Leishmania major hypothetical protein, conserved 0.0018 0.0046 0.0423
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0048 0.0038
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0048 0.0869
Leishmania major DNA polymerase kappa, putative 0.0011 0.0016 0.006
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0444 0.1345
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0048 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Brugia malayi major facilitator superfamily protein 0.0018 0.0047 0.0141
Brugia malayi hypothetical protein 0.0018 0.0047 0.0141
Onchocerca volvulus Sepiapterin reductase homolog 0.0019 0.0048 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0096 0.0334
Entamoeba histolytica hypothetical protein 0.0019 0.0048 0.0053
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0019 0.0048 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.15 0.6149 1
Trypanosoma brucei glucose transporter, putative 0.0018 0.0047 0.1013
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0048 0.011
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0018 0.0047 0.0037
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0019 0.0048 0.0078
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0019 0.0048 0.3715
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0352 0.0349
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0019 0.0048 0.0038
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0056 0.0052
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0047 0.0834
Leishmania major phosphopantetheinyl transferase-like protein 0.0034 0.0113 0.1231
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0048 0.0147
Echinococcus granulosus dna polymerase kappa 0.0011 0.0016 0.0006
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0048 0.0038
Brugia malayi POT family protein 0.0082 0.031 0.1156
Giardia lamblia Sugar-proton symporter 0.0018 0.0047 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0047 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0193 0.0314
Loa Loa (eye worm) hypothetical protein 0.0027 0.0084 0.0284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.046 0.1495
Trypanosoma brucei glucose transporter, putative 0.0018 0.0047 0.1013
Echinococcus multilocularis L aminoadipate semialdehyde 0.0122 0.0474 0.0464
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0148
Echinococcus granulosus solute carrier family 22 0.0018 0.0047 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0017 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.046 0.1495
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0099 0.2041
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0048 0.0869
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0047 0.0076
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0048 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0047 0.0076
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0036 0.0121 0.2692
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0048 0.011
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0019 0.0048 0.0869

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0032 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1853 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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