Detailed information for compound 1432238

Basic information

Technical information
  • TDR Targets ID: 1432238
  • Name: 8-(azepan-1-yl)-1,3-dimethyl-7-(naphthalen-1- ylmethyl)purine-2,6-dione
  • MW: 417.503 | Formula: C24H27N5O2
  • H donors: 0 H acceptors: 3 LogP: 4.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c(=O)n(C)c2c(c1=O)n(Cc1cccc3c1cccc3)c(n2)N1CCCCCC1
  • InChi: 1S/C24H27N5O2/c1-26-21-20(22(30)27(2)24(26)31)29(23(25-21)28-14-7-3-4-8-15-28)16-18-12-9-11-17-10-5-6-13-19(17)18/h5-6,9-13H,3-4,7-8,14-16H2,1-2H3
  • InChiKey: OVYGUOGQNYMHFO-UHFFFAOYSA-N  


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Synonyms

  • 8-(azepan-1-yl)-1,3-dimethyl-7-(1-naphthylmethyl)purine-2,6-dione
  • 8-(1-azepanyl)-1,3-dimethyl-7-(1-naphthylmethyl)purine-2,6-dione
  • 8-(azepan-1-yl)-1,3-dimethyl-7-(1-naphthylmethyl)xanthine
  • STOCK3S-97890
  • MLS000081304
  • SMR000042904
  • ZINC02520832

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0593 1
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.5257 0.5257
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0031 0.0241 0.0241
Entamoeba histolytica protein kinase rad3, putative 0.0201 0.1846 0.1644
Onchocerca volvulus 0.0035 0.0273 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0029 0.0029
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1061 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0201 0.1846 0.1703
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0228 0.2104 0.2104
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0241 0.0223
Mycobacterium tuberculosis Conserved protein 0.0043 0.0356 0.0763
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0367 0.0367
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0356 0.0617
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0593 0.0575
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0639 0.0639
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0368 0.0198
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0575
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0356 0.0763
Brugia malayi CXXC zinc finger family protein 0.0035 0.0273 0.0273
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0052 0.0052
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.039 0.03
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0593 0.0575
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0031 0.0241 0.0095
Entamoeba histolytica hypothetical protein 0.0043 0.0356 0.0117
Brugia malayi Cytochrome P450 family protein 0.0024 0.0173 0.0173
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0353 0.0114
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0052 0.0052
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0367 0.1005
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0367 0.0129
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0247
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1061 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.1887
Brugia malayi hypothetical protein 0.0148 0.1347 0.1347
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0515 0.0515
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.0125
Toxoplasma gondii ABC1 family protein 0.0043 0.0356 0.0253
Giardia lamblia Phosphatidylinositol 4-kinase 0.0068 0.0593 0.036
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0367 0.0268
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0031 0.0241 0.0241
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0173 0.0173
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1061 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0068 0.0593 0.0427
Schistosoma mansoni lamin 0.0033 0.0253 0.0253
Schistosoma mansoni intermediate filament proteins 0.0033 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.0125
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0356 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0052 0.0052
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0068 0.0593 0.1887
Onchocerca volvulus 0.0068 0.0593 0.214
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0639 0.2415
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0368 0.0368
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.6472 0.6466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.5366 0.5357
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0031 0.0241 0.007
Echinococcus granulosus serine protein kinase ATM 0.0201 0.1846 0.1846
Echinococcus granulosus neuropeptide receptor A26 0.056 0.5257 0.5257
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0228 0.2104 0.1966
Schistosoma mansoni inositol monophosphatase 0.0045 0.0367 0.0367
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0125 0.0125
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.2901 0.2901
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0241 0.007
Entamoeba histolytica hypothetical protein 0.0043 0.0356 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0241 0.0223
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.039 0.03
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0125
Leishmania major hypothetical protein, conserved 0.0043 0.0356 0.0187
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.039 0.0799
Leishmania major phosphatidylinositol 3-kinase, putative 0.0356 0.3316 0.3199
Trichomonas vaginalis fk506-binding protein, putative 0.0031 0.0241 0.0223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0068 0.0593 0.0427
Leishmania major phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.0427
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0155 0.1414 0.1414
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0068 0.0593 0.0593
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0356 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0046
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4627 0.4627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0285 0.2642 0.2628
Echinococcus multilocularis smad 0.0009 0.0029 0.0029
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0353 0.0599
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1061 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0068 0.0593 0.0575
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.1887
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.0739 0.0576
Brugia malayi beta-lactamase family protein 0.0043 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0068 0.0593 0.0593
Brugia malayi Cytochrome P450 family protein 0.0084 0.0739 0.0739
Schistosoma mansoni lamin 0.0033 0.0253 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0368 0.035
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0068 0.0593 0.0593
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0068 0.0593 0.0593
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0068 0.0593 0.0593
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1061 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2578 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0228 0.2104 0.209
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0228 0.2104 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0593 0.0575
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0201 0.1846 0.1846
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0125 0.0125
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0046
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0052 0.0052
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1194 0.1194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.5893 0.5886
Schistosoma mansoni inositol monophosphatase 0.0045 0.0367 0.0367
Mycobacterium ulcerans hypothetical protein 0.0043 0.0356 0.095
Brugia malayi beta-lactamase 0.0043 0.0356 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0634 0.5953 0.5945
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0228 0.2104 0.1909
Echinococcus multilocularis 0.0024 0.0173 0.0173
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.9229 0.9229
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0368 0.0129
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0593 0.0575
Schistosoma mansoni fkbp-rapamycin associated protein 0.0201 0.1846 0.1846
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0201 0.1846 0.1846
Mycobacterium tuberculosis Conserved protein 0.0043 0.0356 0.0763
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0093
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0228 0.2104 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1347 0.1347
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.039 0.0372
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.0125
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1461 0.1461
Schistosoma mansoni immunophilin 0.0228 0.2104 0.2104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.5893 0.5886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0356 0.3316 0.3316
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0356 0.0187
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0196 0.1807 0.1807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0031 0.0241 0.0241
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0068 0.0593 0.0593
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0228 0.2104 0.1966
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Schistosoma mansoni hypothetical protein 0.0024 0.0173 0.0173
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0228 0.2104 0.1909
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0356 0.3316 0.3199
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.1887
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Loa Loa (eye worm) hypothetical protein 0.0068 0.0593 0.0593
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0368 0.035
Schistosoma mansoni hypothetical protein 0.0043 0.0356 0.0356
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0356 0.0356
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0068 0.0593 0.0593
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0356 0.3316 0.3199
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0356 0.095
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0356 0.095
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0593 0.0575
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1414 0.1398
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0031 0.0241 0.0285
Loa Loa (eye worm) phosphatidylinositol kinase 0.0068 0.0593 0.0593
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0368 0.0368
Echinococcus multilocularis musashi 0.0033 0.0253 0.0253
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0068 0.0593 0.1887
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0593 0.0575
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0068 0.0593 0.036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.0334
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0228 0.2104 0.2104
Echinococcus multilocularis Smad4 0.0009 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Brugia malayi follicle stimulating hormone receptor 0.0283 0.2623 0.2623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0029 0.0029
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.039 0.0372
Entamoeba histolytica hypothetical protein 0.0068 0.0593 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.5374 0.5365
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0068 0.0593 0.0575
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0642 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.5366 0.5357
Loa Loa (eye worm) hypothetical protein 0.0132 0.1197 0.1197
Loa Loa (eye worm) hypothetical protein 0.0033 0.0253 0.0253
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0639 0.0643
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0015 0.0088 0.0088
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0368 0.0368
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0052 0.0052
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0367 0.0198
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0068 0.0593 0.036
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0639 0.0475
Echinococcus multilocularis lamin dm0 0.0033 0.0253 0.0253
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0241 0.0095
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0173 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0356 0.0356
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0052 0.0052
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0368 0.0368
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0228 0.2104 0.2104
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0052 0.0052
Brugia malayi Inositol-1 0.0045 0.0367 0.0367
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0593 0.0575
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0639 0.2415
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0109 0.0109
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0031 0.0241 0.1631
Trichomonas vaginalis fk506-binding protein, putative 0.0228 0.2104 0.209
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0068 0.0593 0.0593
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0228 0.2104 0.1966
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0253 0.0253
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1061 1 1
Trichomonas vaginalis esterase, putative 0.0043 0.0356 0.0338
Schistosoma mansoni cpg binding protein 0.0037 0.0292 0.0292
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0427
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0088 0.0088
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1061 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0068 0.0593 0.1887
Loa Loa (eye worm) hypothetical protein 0.0224 0.2063 0.2063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0356 0.0356
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0241 0.0095
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0334 0.0334
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0367 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1061 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0634 0.5953 0.5945
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.1418 0.1418
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0356 0.0356
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0088 0.0088
Leishmania major phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0427
Echinococcus granulosus Smad4 0.0009 0.0029 0.0029
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0427
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0068 0.0593 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Brugia malayi Cytochrome P450 family protein 0.0084 0.0739 0.0739
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.0739 0.0576
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0228 0.2104 0.1909
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0036 0.0036
Schistosoma mansoni smad 0.0009 0.0029 0.0029
Echinococcus granulosus cpg binding protein 0.0037 0.0292 0.0292
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0125 0.0125
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0068 0.0593 0.0593
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0068 0.0593 0.0593
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0368 0.0368
Onchocerca volvulus 0.0068 0.0593 0.214
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0031 0.0241 0.0241
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0368 0.0129
Echinococcus multilocularis 0.0068 0.0593 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.2063 0.2048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1846 0.1831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0356 0.0356
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0125 0.0125
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0323 0.3567
Loa Loa (eye worm) phosphatidylinositol 3 0.1061 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0052 0.0033
Brugia malayi MH2 domain containing protein 0.0132 0.1194 0.1194
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0356 0.3316 0.3199
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0593 0.1887
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0356 0.0338
Loa Loa (eye worm) hypothetical protein 0.0201 0.1846 0.1846
Entamoeba histolytica hypothetical protein 0.0068 0.0593 0.036
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0031 0.0241 0.0241
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0367 0.0349
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0068 0.0593 0.0575
Schistosoma mansoni immunophilin 0.0196 0.1807 0.1807
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0052 0.0052
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0068 0.0593 0.0593
Echinococcus granulosus lamin dm0 0.0033 0.0253 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.1061 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Brugia malayi intermediate filament protein 0.0033 0.0253 0.0253
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0031 0.0241 0.0241
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0356 0.0763
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0356 0.0763
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0068 0.0593 0.0427
Brugia malayi Cytochrome P450 family protein 0.0024 0.0173 0.0173
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0356 0.3316 0.3316
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.1846 0.1846
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0132 0.1197 0.1042
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1061 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0068 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0196 0.1807 0.1807
Leishmania major hypothetical protein, unknown function 0.0068 0.0593 0.0427
Brugia malayi MH1 domain containing protein 0.0009 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0593 0.0575
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0356 0.0187
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0368 0.035
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0068 0.0593 0.0427
Onchocerca volvulus Huntingtin homolog 0.0148 0.1347 0.6729
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0367 0.0349
Schistosoma mansoni hypothetical protein 0.0041 0.0334 0.0334
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0068 0.0593 0.0593
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0356 0.0763
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0031 0.0241 0.0241
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0228 0.2104 0.2104
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0068 0.0593 0.0575
Brugia malayi beta-lactamase family protein 0.0043 0.0356 0.0356
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0368 0.0368
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0593 0.0575
Echinococcus multilocularis serine protein kinase ATM 0.0201 0.1846 0.1846
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0639 0.194
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0639 0.0639
Schistosoma mansoni smad1 5 8 and 0.0009 0.0029 0.0029
Leishmania major cytochrome p450-like protein 0.0084 0.0739 0.0576
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.3316 0.3316
Echinococcus granulosus intermediate filament protein 0.0033 0.0253 0.0253
Loa Loa (eye worm) FKBP5 protein 0.0228 0.2104 0.2104
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Echinococcus granulosus smad 0.0009 0.0029 0.0029
Brugia malayi cytochrome P450 0.0024 0.0173 0.0173
Giardia lamblia GTOR 0.1061 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.039 0.039
Schistosoma mansoni 60S ribosomal protein L21 0.001 0.0036 0.0036
Plasmodium vivax hypothetical protein 0.0068 0.0593 0.1887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.1197 0.1181
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Loa Loa (eye worm) acetyltransferase 0.016 0.1461 0.1461
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0368 0.0198
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0224 0.2063 0.2607
Entamoeba histolytica hypothetical protein 0.0068 0.0593 0.036
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0368 0.0198
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0353 0.0114
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0029 0.0029
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0368 0.0368
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0356 0.0338
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0228 0.2104 0.1909
Loa Loa (eye worm) hypothetical protein 0.0039 0.0316 0.0316
Giardia lamblia Hypothetical protein 0.0068 0.0593 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.853 0.8527
Trichomonas vaginalis fk506-binding protein, putative 0.0031 0.0241 0.0223
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0155 0.1414 0.1414
Mycobacterium ulcerans beta-lactamase 0.0043 0.0356 0.095
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1061 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0125 0.0125
Toxoplasma gondii FATC domain-containing protein 0.0201 0.1846 0.2308
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1197 0.1181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0515 0.0515
Trichomonas vaginalis immunophilin, putative 0.0228 0.2104 0.209
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0405 0.0405
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0323 0.0623
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0031 0.0241 0.007
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1194 0.1194
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0367 0.0367
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0844 0.7951 0.7915
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0045 0.0045
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0029 0.0029
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0068 0.0593 0.0593
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0068 0.0593 0.0427
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0368 0.0368
Brugia malayi MH1 domain containing protein 0.0009 0.0029 0.0029
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0068 0.0593 0.0593
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Echinococcus granulosus neuropeptide s receptor 0.056 0.5257 0.5257
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0052 0.0052
Schistosoma mansoni fk506 binding protein 0.0031 0.0241 0.0241
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0084 0.0739 0.2932
Loa Loa (eye worm) hypothetical protein 0.0045 0.0368 0.0368
Schistosoma mansoni smad1 5 8 and 0.0009 0.0029 0.0029
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0031 0.0241 0.0241
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0427
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0228 0.2104 0.2104
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0356 0.0356
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0088 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Schistosoma mansoni immunophilin 0.0228 0.2104 0.2104
Schistosoma mansoni cpg binding protein 0.0037 0.0292 0.0292
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0068 0.0593 0.0593
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0068 0.0593 0.0593
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.0427
Echinococcus granulosus FK506 binding protein 2 0.0031 0.0241 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.5374 0.5365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.5374 0.5365
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Leishmania major fk506-binding protein 1-like protein 0.0228 0.2104 0.1966
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0125 0.0125
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0228 0.2104 0.2104
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0228 0.2104 0.1966
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1461 0.1461
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0356 0.0356
Onchocerca volvulus 0.0043 0.0356 0.07
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0639 0.2415
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1461 0.1461
Trichomonas vaginalis PIKK family atypical protein kinase 0.1061 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0441 0.4121 0.4017
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0201 0.1846 0.1703
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0356 0.0763
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0046 0.0046
Echinococcus multilocularis cpg binding protein 0.0037 0.0292 0.0292
Onchocerca volvulus 0.0043 0.0356 0.07
Schistosoma mansoni hypothetical protein 0.0068 0.0593 0.0593
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0368 0.0368
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0228 0.2104 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0088 0.0088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0367 0.0198
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0368 0.0368
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0068 0.0593 0.0593
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0356 0.3316 0.3199
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0356 0.0187
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0088 0.0088
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0634 0.5953 0.5945
Mycobacterium leprae Probable lipase LipE 0.0043 0.0356 0.4368
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0068 0.0593 0.0575
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0068 0.0593 0.0593
Leishmania major peptidylprolyl isomerase-like protein 0.0228 0.2104 0.1966
Onchocerca volvulus 0.0033 0.0253 0.007
Trichomonas vaginalis fk506 binding protein, putative 0.0031 0.0241 0.0223
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0356 0.0356
Onchocerca volvulus 0.0043 0.0356 0.07
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0368 0.0368
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0356 0.0763
Entamoeba histolytica hypothetical protein 0.0201 0.1846 0.1644
Entamoeba histolytica hypothetical protein 0.0043 0.0356 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0356 0.0338
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0228 0.2104 0.2104
Loa Loa (eye worm) inositol-1 0.0045 0.0367 0.0367
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Mycobacterium ulcerans lipase LipD 0.0043 0.0356 0.095
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0228 0.2104 0.209
Echinococcus multilocularis lamin 0.0033 0.0253 0.0253
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0068 0.0593 0.0427
Brugia malayi MH2 domain containing protein 0.0009 0.0029 0.0029
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0052 0.0052
Onchocerca volvulus Huntingtin homolog 0.0148 0.1347 0.6729
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0088 0.0088
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0052 0.0052
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0273 0.0273
Echinococcus multilocularis 0.0031 0.0241 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1989 0.1974
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1989 0.1974
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0029 0.0029
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.2901 0.2901
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0367 0.0349
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0368 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1846 0.1831
Echinococcus multilocularis fk506 binding protein 0.0228 0.2104 0.2104
Loa Loa (eye worm) hypothetical protein 0.006 0.051 0.051
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0026 0.0026
Loa Loa (eye worm) CYP4Cod1 0.0084 0.0739 0.0739
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0844 0.7951 0.7915
Trypanosoma brucei cytochrome P450, putative 0.0084 0.0739 0.0576
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0313 0.0295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0515 0.0515
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0031 0.0241 0.5
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.0125
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0228 0.2104 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0739 0.0739
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0356 0.3316 0.3316
Loa Loa (eye worm) hypothetical protein 0.006 0.0515 0.0515
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.3316 0.3316
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0068 0.0593 0.0593
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0088 0.0088
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0228 0.2104 0.1966
Trichomonas vaginalis PIKK family atypical protein kinase 0.1061 1 1
Echinococcus granulosus lamin 0.0033 0.0253 0.0253
Schistosoma mansoni Smad4 0.0009 0.0029 0.0029
Schistosoma mansoni cpg binding protein 0.0035 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0068 0.0593 0.036
Entamoeba histolytica hypothetical protein 0.0068 0.0593 0.036
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0739 0.0739
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0052 0.0033
Toxoplasma gondii target of rapamycin (TOR), putative 0.0789 0.7423 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0068 0.0593 0.036
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0068 0.0593 0.1887
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Loa Loa (eye worm) hypothetical protein 0.0155 0.1414 0.1414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0196 0.1807 0.1807
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0201 0.1846 0.1846
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0241 0.0095
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0031 0.0241 0.007
Brugia malayi hypothetical protein 0.0043 0.0356 0.0356
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0405 0.0405
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0031 0.0241 0.0241
Mycobacterium tuberculosis Conserved hypothetical protein 0.0068 0.0593 0.1746
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0604 0.0595
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0068 0.0593 0.0427
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0125 0.0125
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0356 0.3316 0.3199
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0356 0.0763
Entamoeba histolytica hypothetical protein 0.0043 0.0356 0.0117
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0068 0.0593 0.0427
Leishmania major phosphatidylinositol kinase related protein, putative 0.0068 0.0593 0.0427
Mycobacterium tuberculosis Conserved protein 0.0043 0.0356 0.0763
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Onchocerca volvulus 0.0033 0.0253 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.1884 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0068 0.0593 0.0593
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0093 0.0093
Schistosoma mansoni smad1 5 8 and 0.0009 0.0029 0.0029
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0368 0.0368
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4627 0.4627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Schistosoma mansoni hypothetical protein 0.0031 0.0241 0.0241
Loa Loa (eye worm) cytochrome P450 0.0024 0.0173 0.0173
Loa Loa (eye worm) Smad1 0.0009 0.0029 0.0029
Brugia malayi MH2 domain containing protein 0.0009 0.0029 0.0029
Trypanosoma cruzi target of rapamycin kinase 3 0.0844 0.7951 0.7915
Echinococcus multilocularis neuropeptide s receptor 0.056 0.5257 0.5257
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0093 0.0093
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0201 0.1846 0.1703
Loa Loa (eye worm) hypothetical protein 0.0216 0.1993 0.1993
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0502 0.47 0.4606
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0228 0.2104 0.1966
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.2623 0.2623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1846 0.1831
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0068 0.0593 0.0593
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.0427
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0068 0.0593 0.0593
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0052 0.0052
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0068 0.0593 0.0593
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0052 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0639 0.0639
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0368 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Echinococcus granulosus GPCR family 2 0.0019 0.0125 0.0125
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.1846 0.1846
Leishmania major phosphatidylinositol kinase, putative 0.0068 0.0593 0.0427
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0313 0.0295
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.5366 0.5357
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0367 0.0198
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0201 0.1846 0.1644
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Brugia malayi FAT domain containing protein 0.0155 0.1414 0.1414
Schistosoma mansoni hypothetical protein 0.0155 0.1414 0.1414
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.5374 0.5365
Leishmania major hypothetical protein, conserved 0.0068 0.0593 0.0427
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0639 0.0639
Echinococcus multilocularis GPCR, family 2 0.0019 0.0125 0.0125
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Schistosoma mansoni cytochrome P450 0.0024 0.0173 0.0173
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0068 0.0593 0.0427
Loa Loa (eye worm) hypothetical protein 0.0148 0.1347 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0711 0.6689 0.6683
Echinococcus multilocularis Zinc finger, PHD finger 0.0068 0.0593 0.0593
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0029 0.0029
Mycobacterium ulcerans hypothetical protein 0.0031 0.0241 0.0355
Schistosoma mansoni hypothetical protein 0.0494 0.4627 0.4627
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0356 0.4368
Loa Loa (eye worm) beta-lactamase 0.0043 0.0356 0.0356
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1061 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0367 0.0198
Brugia malayi Smad1 0.0009 0.0029 0.0029

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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