Detailed information for compound 143410

Basic information

Technical information
  • TDR Targets ID: 143410
  • Name: (2S,9R,12E,15S)-9-[(3-chloro-4-methoxyphenyl) methyl]-5,5-dimethyl-2-(2-methylpropyl)-15-[( E,2R)-4-phenylbut-3-en-2-yl]-3,16-dioxa-7,10- diazacyclohexadec-12-ene-1,4,8,11-tetrone
  • MW: 653.205 | Formula: C36H45ClN2O7
  • H donors: 2 H acceptors: 4 LogP: 7.43 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1Cl)C[C@H]1NC(=O)/C=C/C[C@H](OC(=O)[C@@H](OC(=O)C(CNC1=O)(C)C)CC(C)C)[C@@H](/C=C/c1ccccc1)C
  • InChi: 1S/C36H45ClN2O7/c1-23(2)19-31-34(42)45-29(24(3)15-16-25-11-8-7-9-12-25)13-10-14-32(40)39-28(21-26-17-18-30(44-6)27(37)20-26)33(41)38-22-36(4,5)35(43)46-31/h7-12,14-18,20,23-24,28-29,31H,13,19,21-22H2,1-6H3,(H,38,41)(H,39,40)/b14-10+,16-15+/t24-,28-,29+,31+/m1/s1
  • InChiKey: LTVIBOLRUXBENE-MSXGYFQQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,9R,12E,15S)-9-[(3-chloro-4-methoxy-phenyl)methyl]-2-isobutyl-5,5-dimethyl-15-[(E,1R)-1-methyl-3-phenyl-allyl]-3,16-dioxa-7,10-diazacyclohexadec-12-ene-1,4,8,11-tetrone
  • (2S,9R,12E,15S)-9-[(3-chloro-4-methoxyphenyl)methyl]-2-isobutyl-5,5-dimethyl-15-[(E,1R)-1-methyl-3-phenylallyl]-3,16-dioxa-7,10-diazacyclohexadec-12-ene-1,4,8,11-tetrone
  • (2S,9R,12E,15S)-9-[(3-chloro-4-methoxy-phenyl)methyl]-5,5-dimethyl-2-(2-methylpropyl)-15-[(E,2R)-4-phenylbut-3-en-2-yl]-3,16-dioxa-7,10-diazacyclohexadec-12-ene-1,4,8,11-tetrone
  • (2S,9R,12E,15S)-9-(3-chloro-4-methoxy-benzyl)-2-isobutyl-5,5-dimethyl-15-[(E,1R)-1-methyl-3-phenyl-allyl]-3,16-dioxa-7,10-diazacyclohexadec-12-ene-1,4,8,11-diquinone
  • (3S,10R,13E,16S)-10-[(3-chloro-4-methoxyphenyl)methyl]-6,6-dimethyl-3-(2-methylpropyl)-16-[(E,2R)-4-phenylbut-3-en-2-yl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
  • (3S,10R,13E,16S)-10-[(3-chloro-4-methoxy-phenyl)methyl]-3-isobutyl-6,6-dimethyl-16-[(E,1R)-1-methyl-3-phenyl-prop-2-enyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
  • (3S,10R,13E,16S)-10-[(3-chloro-4-methoxyphenyl)methyl]-3-isobutyl-6,6-dimethyl-16-[(E,1R)-1-methyl-3-phenylprop-2-enyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
  • (3S,10R,13E,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-16-[(E,1R)-1-methyl-3-phenyl-prop-2-enyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-diquinone
  • (3S,10R,13E,16S)-10-[(3-chloro-4-methoxy-phenyl)methyl]-6,6-dimethyl-3-(2-methylpropyl)-16-[(E,2R)-4-phenylbut-3-en-2-yl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0124 0.0316
Echinococcus multilocularis calcium activated potassium channel 0.002 0.0009 0.0002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0085 0.0079
Brugia malayi neuropeptide F receptor 0.0029 0.0064 0.0182
Brugia malayi neuropeptide F receptor 0.0029 0.0064 0.0182
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0064 0.0057
Brugia malayi laminin alpha chain 0.0024 0.0034 0.0087
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0165 0.0158
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0064 0.0057
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0085 0.0698
Brugia malayi hypothetical protein 0.0022 0.0023 0.0051
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0251 0.0244
Loa Loa (eye worm) hypothetical protein 0.0135 0.0669 0.1777
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Brugia malayi glutathione reductase 0.0096 0.0445 0.1402
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Loa Loa (eye worm) ion channel NompC 0.002 0.0007 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0251 0.1939
Brugia malayi Cytochrome P450 family protein 0.004 0.0124 0.0375
Echinococcus multilocularis glutamate receptor 2 0.0094 0.0431 0.0424
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0018 0.0134
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.0488 0.4137
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0018 0.0134
Giardia lamblia Pyruvate kinase 0.0038 0.0113 0.0696
Onchocerca volvulus 0.0039 0.0118 0.0461
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0018 0.0092
Onchocerca volvulus 0.0026 0.0044 0.0155
Brugia malayi metabotropic glutamate receptor type 2 0.0048 0.017 0.0521
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0015 0.0018
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0024 0.0034 0.0057
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0018 0.0092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1093 0.2916
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0209 0.0432
Trichomonas vaginalis pyruvate kinase, putative 0.0074 0.0321 0.2506
Brugia malayi enteropeptidase precursor 0.0057 0.0224 0.0695
Echinococcus granulosus acetylcholinesterase 0.0135 0.0669 0.1411
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0085 0.0698
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0048 0.017 0.0439
Echinococcus granulosus neuroligin 0.0023 0.0026 0.004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0064 0.0121
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0024 0.0034 0.0215
Loa Loa (eye worm) hypothetical protein 0.0214 0.1122 0.2991
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0064 0.0121
Echinococcus multilocularis pyruvate kinase 0.0038 0.0113 0.0107
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.1379 0.1373
Schistosoma mansoni neuroligin 3 (S09 family) 0.0023 0.0026 0.004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Brugia malayi CXXC zinc finger family protein 0.0031 0.0075 0.0218
Brugia malayi hypothetical protein 0.0022 0.0023 0.0051
Entamoeba histolytica Ran family GTPase 0.0046 0.016 0.1147
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0055 0.0209 0.0545
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.006 0.0113
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0034 0.0027
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0445 1
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0064 0.0057
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0044 0.0298
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0085 0.1793
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0064 0.0121
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.1149 0.8716
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0118 0.0885
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0216 0.1131 0.2396
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.016 0.0412
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.1318 1
Echinococcus multilocularis RUN 0.0022 0.0023 0.0016
Brugia malayi TAR-binding protein 0.0135 0.0669 0.2121
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0117 0.0111
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0118 0.0885
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0101
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0064 0.0121
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0018 0.0092
Brugia malayi G-protein coupled receptor 0.0029 0.0064 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0488 0.3841
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0219 0.1149 0.8899
Echinococcus granulosus hypothetical protein 0.0029 0.0064 0.0121
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0118 0.0893
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0118 0.0299
Echinococcus granulosus glutamate receptor 2 0.0142 0.0705 0.1489
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0018 0.0092
Echinococcus granulosus basement membrane specific heparan sulfate 0.0057 0.0224 0.0463
Onchocerca volvulus 0.0029 0.0064 0.0238
Onchocerca volvulus 0.0029 0.0064 0.0238
Onchocerca volvulus 0.0029 0.0064 0.0238
Trypanosoma brucei pyruvate kinase 1, putative 0.0074 0.0321 0.2791
Onchocerca volvulus 0.0039 0.0118 0.0461
Entamoeba histolytica pyruvate kinase, putative 0.0052 0.0192 0.144
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0118 0.0236
Echinococcus multilocularis snurportin 1 0.0671 0.3736 0.3731
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0064 0.0121
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0488 0.4278
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0064 0.0155
Trypanosoma cruzi pyruvate kinase 2, putative 0.0074 0.0321 0.2791
Echinococcus granulosus pikachurin 0.0024 0.0034 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0565 0.313 0.6658
Echinococcus granulosus Niemann Pick C1 protein 0.0214 0.1122 0.2377
Echinococcus multilocularis pyruvate kinase 0.0038 0.0113 0.0107
Echinococcus granulosus allatostatin A receptor 0.0029 0.0064 0.0121
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0075
Loa Loa (eye worm) hypothetical protein 0.0164 0.0832 0.2215
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0333 0.7452
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.002 0.0007 0.0002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.1149 0.8716
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0085 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Trichomonas vaginalis ran, putative 0.0046 0.016 0.1221
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0024 0.0034 0.0086
Chlamydia trachomatis glutamine binding protein 0.024 0.1268 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0018 0.0092
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0064 0.0155
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0176 0.09 0.7085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0565 0.313 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0391 0.1032
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Plasmodium falciparum pyruvate kinase 0.0074 0.0321 0.7171
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0023 0.0034
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0064 0.0121
Onchocerca volvulus 0.0029 0.0064 0.0238
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.017 0.0521
Brugia malayi Cytochrome P450 family protein 0.0021 0.0018 0.0035
Leishmania major GTP-binding protein, putative 0.0046 0.016 0.1359
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0064 0.0121
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0064 0.0057
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0214 0.1122 0.9919
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0018 0.0134
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0299
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Loa Loa (eye worm) acetylcholinesterase 1 0.0135 0.0669 0.1777
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0187 0.1436
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0565 0.313 0.6658
Echinococcus multilocularis glutamate receptor 2 0.0048 0.017 0.0163
Plasmodium vivax importin-beta 2, putative 0.0063 0.0255 0.5669
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0015 0.0008
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0142 0.0705 0.1489
Schistosoma mansoni hypothetical protein 0.0039 0.0117 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0018 0.0134
Brugia malayi PHD-finger family protein 0.0026 0.0044 0.0118
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Schistosoma mansoni amine GPCR 0.0029 0.0064 0.0121
Schistosoma mansoni hypothetical protein 0.0089 0.0402 0.0843
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.017 0.0439
Echinococcus multilocularis pyruvate kinase 0.0038 0.0113 0.0107
Echinococcus granulosus nmda type glutamate receptor 0.0821 0.46 0.9791
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0085 0.0698
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0018 0.0134
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0064 0.0121
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0064 0.0057
Echinococcus granulosus neuropeptide receptor 0.0029 0.0064 0.0121
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0094 0.0431 0.0904
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0669 0.1412
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0251 0.052
Schistosoma mansoni amine GPCR 0.0029 0.0064 0.0121
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.1379 0.2924
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.016 0.3503
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0565 0.313 0.3125
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0217 0.1141 0.2417
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0094 0.0431 0.0904
Schistosoma mansoni biogenic amine receptor 0.0029 0.0064 0.0121
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0176 0.09 0.1905
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0064 0.0057
Brugia malayi larval opioid receptor 0.0029 0.0064 0.0182
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0024 0.0034 0.0057
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0064 0.0155
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0034 0.0087
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0176 0.09 0.2861
Plasmodium vivax glutathione reductase, putative 0.0096 0.0445 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0048 0.017 0.0163
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0018 0.0031
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus low density lipoprotein receptor protein 0.0057 0.0224 0.0463
Echinococcus multilocularis sterol regulatory element binding protein 0.0092 0.0421 0.0415
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0669 0.1778
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0024 0.0034 0.0086
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.017 0.0521
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0023 0.0016
Echinococcus multilocularis tumor protein p63 0.0365 0.1985 0.198
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0024 0.0034 0.0086
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0064 0.0121
Echinococcus granulosus slit 2 protein 0.0026 0.0042 0.0076
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0031 0.0051
Loa Loa (eye worm) RNA binding protein 0.0135 0.0669 0.1778
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0044 0.0331
Loa Loa (eye worm) hypothetical protein 0.0092 0.0421 0.1114
Echinococcus multilocularis short transient receptor potential channel 6 0.0021 0.0015 0.0008
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0026 0.004
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0101
Echinococcus granulosus g protein coupled receptor 0.0029 0.0064 0.0121
Brugia malayi hypothetical protein 0.0048 0.017 0.0521
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0052
Schistosoma mansoni histamine h1 receptor 0.0029 0.0064 0.0121
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0094 0.0431 0.0424
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0333 0.7447
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0018 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0669 0.1412
Schistosoma mansoni rab6-interacting 0.0022 0.0023 0.0034
Entamoeba histolytica hypothetical protein 0.0039 0.0117 0.0762
Onchocerca volvulus Arrow homolog 0.0057 0.0224 0.0901
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0187 0.1599
Schistosoma mansoni lipoxygenase 0.0022 0.0023 0.0034
Schistosoma mansoni hypothetical protein 0.0053 0.0198 0.0406
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Schistosoma mansoni acetylcholinesterase 0.0023 0.0026 0.004
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.0007 0.0002
Schistosoma mansoni amine GPCR 0.0029 0.0064 0.0121
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.1149 0.8716
Onchocerca volvulus 0.0029 0.0064 0.0238
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0024 0.0034 0.0086
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0695
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0057 0.0224 0.0584
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0118 0.0111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.0064 0.0238
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0187 0.1436
Echinococcus granulosus zinc finger protein 0.0021 0.0014 0.0015
Loa Loa (eye worm) MBCTL1 0.0055 0.0209 0.0545
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus multilocularis geminin 0.0838 0.4698 0.4694
Schistosoma mansoni opsin-like receptor 0.0029 0.0064 0.0121
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0018 0.0134
Brugia malayi Dopamine receptor 0.0029 0.0064 0.0182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0064 0.0155
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0045
Schistosoma mansoni hypothetical protein 0.0057 0.0224 0.0463
Schistosoma mansoni neuropeptide receptor 0.0029 0.0064 0.0121
Schistosoma mansoni neuropeptide receptor 0.0029 0.0064 0.0121
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0095 0.0188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0064 0.0057
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0057 0.0224 0.0463
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.031
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0251 0.052
Brugia malayi hypothetical protein 0.0024 0.0034 0.0086
Mycobacterium ulcerans hypothetical protein 0.0026 0.0044 0.0298
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0018 0.0134
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0237 0.0491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus glutamate NMDA receptor subunit 0.0094 0.0431 0.0904
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0116 0.0349
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0085 0.1809
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Toxoplasma gondii ABC1 family protein 0.0039 0.0118 0.253
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0064 0.0155
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0057 0.0224 0.0901
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0024 0.0034 0.0215
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0026 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0135 0.0669 0.1411
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0064 0.0057
Schistosoma mansoni transient receptor potential channel 0.002 0.0007 0.0000000153
Echinococcus granulosus glutamate receptor NMDA 0.0488 0.269 0.5721
Echinococcus multilocularis neuroligin 0.0023 0.0026 0.0019
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.024 0.1268 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0085 0.1809
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0045
Mycobacterium tuberculosis Carboxylesterase LipT 0.0023 0.0026 0.0195
Echinococcus multilocularis Protein lozenge 0.0055 0.0212 0.0205
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0171 0.0164
Schistosoma mansoni lozenge 0.0055 0.0212 0.0437
Brugia malayi Importin beta-1 subunit 0.0063 0.0255 0.0793
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0488 0.3841
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0018 0.0134
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0018 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0488 0.3841
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0024 0.0034 0.0057
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0091 0.0084
Trichomonas vaginalis pyruvate kinase, putative 0.0074 0.0321 0.2506
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0064 0.0121
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0048 0.017 0.0439
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0445 0.0438
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.007 0.0063
Schistosoma mansoni polycystin 1-related 0.0022 0.0023 0.0034
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0695
Schistosoma mansoni hypothetical protein 0.0838 0.4698 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0299
Onchocerca volvulus 0.0029 0.0064 0.0238
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0018 0.0246
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0057 0.0224 0.0217
Brugia malayi beta-lactamase family protein 0.0039 0.0118 0.0355
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0064 0.0121
Giardia lamblia Kinase, PLK 0.0103 0.0488 1
Schistosoma mansoni slit 0.0026 0.0042 0.0076
Loa Loa (eye worm) calcium channel 0.002 0.0007 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0064 0.0057
Schistosoma mansoni BC026374 protein (S09 family) 0.0023 0.0026 0.004
Loa Loa (eye worm) carboxylesterase 0.0135 0.0669 0.1777
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0064 0.0121
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0085 0.1793
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0565 0.313 0.3125
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0064 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0064 0.0057
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0024 0.0034 0.0057
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0057 0.0224 0.0217
Brugia malayi Cytochrome P450 family protein 0.0021 0.0018 0.0035
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0118 0.0355
Onchocerca volvulus 0.0024 0.0034 0.0114
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0333 0.2901
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0091 0.018
Loa Loa (eye worm) beta-lactamase 0.0039 0.0118 0.0299
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0018 0.0134
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0118 0.0893
Echinococcus granulosus acetylcholinesterase 0.0135 0.0669 0.1411
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0064 0.0057
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0142 0.0705 0.1489
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Echinococcus granulosus somatostatin receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) glutamate receptor 1 0.0094 0.0431 0.1139
Loa Loa (eye worm) hypothetical protein 0.0259 0.1379 0.368
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0064 0.0057
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0333 0.7452
Schistosoma mansoni biogenic amine receptor 0.0029 0.0064 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0085 0.0698
Loa Loa (eye worm) hypothetical protein 0.0063 0.0255 0.0667
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0024 0.0034 0.0086
Schistosoma mansoni transient receptor potential channel 0.002 0.0007 0.0000000153
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0075 0.0185
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0024 0.0034 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0299
Brugia malayi Cytochrome P450 family protein 0.0021 0.0018 0.0035
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0048 0.017 0.0676
Schistosoma mansoni survival motor neuron protein 0.0053 0.0198 0.0406
Schistosoma mansoni zinc finger protein 0.0021 0.0014 0.0015
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0026 0.004
Loa Loa (eye worm) carboxylesterase 0.0023 0.0026 0.0052
Schistosoma mansoni neuropeptide receptor 0.0029 0.0064 0.0121
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0669 0.1412
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0695
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0064 0.0057
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0216 0.1131 1
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0188 0.1449
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0488 0.4278
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus multilocularis acetylcholinesterase 0.0135 0.0669 0.0662
Brugia malayi Pyruvate kinase, muscle isozyme 0.0074 0.0321 0.1004
Schistosoma mansoni hypothetical protein 0.0671 0.3736 0.7949
Echinococcus granulosus pyruvate kinase 0.0038 0.0113 0.0227
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0085 0.0628
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0064 0.0121
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0034 0.0087
Schistosoma mansoni hypothetical protein 0.0057 0.0224 0.0463
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0024 0.0034 0.0057
Brugia malayi putative neuropeptide receptor 0.0029 0.0064 0.0182
Echinococcus multilocularis NMDA receptor 0.0094 0.0431 0.0424
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0445 0.0933
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0064 0.0121
Schistosoma mansoni glutamate receptor AMPA 0.0094 0.0431 0.0904
Loa Loa (eye worm) hypothetical protein 0.0069 0.0289 0.0757
Trypanosoma brucei pyruvate kinase 1 0.0074 0.0321 0.2791
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0522
Onchocerca volvulus 0.0023 0.0026 0.008
Echinococcus granulosus BC026374 protein S09 family 0.0023 0.0026 0.004
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0064 0.0057
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) pyruvate kinase 0.0074 0.0321 0.0843
Schistosoma mansoni tyrosine kinase 0.0048 0.017 0.0347
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.024 0.1268 1
Leishmania major importin beta-1 subunit, putative 0.0051 0.0187 0.1599
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.016 0.1359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0044 0.0118
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0064 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0488 0.3841
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0064 0.0182
Brugia malayi Serotonin receptor 0.0029 0.0064 0.0182
Brugia malayi mbt repeat family protein 0.0048 0.0171 0.0526
Echinococcus multilocularis nmda type glutamate receptor 0.0821 0.46 0.4596
Schistosoma mansoni ATP-binding cassette transporter 0.0094 0.0431 0.0904
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0064 0.0057
Echinococcus multilocularis pyruvate kinase 0.0059 0.0231 0.0224
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0024 0.0034 0.0057
Echinococcus granulosus nmda type glutamate receptor 0.0536 0.2965 0.6306
Brugia malayi RNA binding protein 0.0135 0.0669 0.2121
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0024 0.0034 0.0057
Echinococcus multilocularis zinc finger protein 0.0021 0.0014 0.0007
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0064 0.0057
Echinococcus multilocularis expressed protein 0.0024 0.0034 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0251 0.1939
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0142 0.0705 0.0699
Echinococcus multilocularis receptor type guanylyl cyclase 0.0048 0.017 0.0163
Loa Loa (eye worm) hypothetical protein 0.0087 0.0391 0.1032
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0007 0.0002
Schistosoma mansoni neuropeptide receptor 0.0029 0.0064 0.0121
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0064 0.0121
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0074 0.0321 0.2432
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0118 0.2545
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0251 0.217
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0018 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0085 0.0698
Onchocerca volvulus 0.0057 0.0224 0.0901
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0024 0.0034 0.0057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0018 0.0134
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0064 0.0155
Loa Loa (eye worm) hypothetical protein 0.0056 0.0218 0.0569
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0251 0.1939
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0064 0.0182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0275
Schistosoma mansoni transient receptor potential channel 0.0021 0.0015 0.0018
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0171 0.0164
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0015 0.0008
Echinococcus granulosus short transient receptor potential channel 6 0.0021 0.0015 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0085 0.0698
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0164 0.0833 0.2217
Echinococcus multilocularis glutamate receptor NMDA 0.0488 0.269 0.2685
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0243 0.1289 0.9778
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0064 0.0057
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0064 0.0121
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0026 0.004
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0018 0.0134
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0118 0.0885
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0251 0.5571
Brugia malayi Carboxylesterase family protein 0.0135 0.0669 0.2119
Echinococcus granulosus sex peptide receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0426
Echinococcus multilocularis slit 2 protein 0.0026 0.0042 0.0035
Brugia malayi CUB domain containing protein 0.0057 0.0224 0.0695
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0209 0.0648
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Plasmodium vivax SET domain protein, putative 0.0031 0.007 0.1462
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0198 0.061
Plasmodium falciparum glutathione reductase 0.0033 0.0085 0.1809
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.002 0.0007 0.0003
Chlamydia trachomatis pyruvate kinase 0.0074 0.0321 0.2491
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0085 0.1809
Schistosoma mansoni tyrosine kinase 0.0048 0.017 0.0347
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0024 0.0034 0.0075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0237 0.0231
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0218 0.0676
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Loa Loa (eye worm) ryanodine receptor 0.002 0.0007 0.0002
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.016 0.0489
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0018 0.0096
Brugia malayi AKH receptor 0.0029 0.0064 0.0182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0052
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0057 0.0224 0.0463
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0018 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0118 0.0236
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0064 0.0121
Onchocerca volvulus 0.0031 0.0075 0.0285
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0018 0.0092
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0024 0.0034 0.0075
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0445 0.3373
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0064 0.0155
Loa Loa (eye worm) glutamate receptor 2 0.0094 0.0431 0.1139
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0085 0.0167
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0255 0.5661
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0064 0.0121
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0064 0.0121
Onchocerca volvulus 0.0022 0.0023 0.0068
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0064 0.0121
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0018 0.0134
Loa Loa (eye worm) PHD-finger family protein 0.002 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0034 0.0091 0.018
Brugia malayi olfactory channel protein osm-9 0.0021 0.0015 0.0027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.007 0.1445
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus Niemann Pick C1 protein 0.0306 0.1648 0.3499
Brugia malayi RE15519p 0.0029 0.0064 0.0182
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0018 0.0096
Echinococcus granulosus neuropeptide receptor 0.0029 0.0064 0.0121
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0035 0.0089
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.017 0.0439
Onchocerca volvulus 0.0057 0.0224 0.0901
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0018 0.0092
Brugia malayi G protein-coupled receptor 0.0029 0.0064 0.0182
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0018 0.0092
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0085 0.0698
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0057 0.0224 0.0901
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0064 0.0121
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0044 0.0331
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0064 0.0182
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0024 0.0034 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0669 0.2121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Leishmania major cytochrome p450-like protein 0.0021 0.0018 0.0096
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0085 0.0698
Echinococcus granulosus para nitrobenzyl esterase 0.0023 0.0026 0.004
Schistosoma mansoni protein kinase 0.0048 0.017 0.0347
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0057 0.0224 0.0695
Onchocerca volvulus 0.0023 0.0026 0.008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.024 0.1268 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0253 0.0524
Onchocerca volvulus Pyruvate kinase homolog 0.0074 0.0321 0.1301
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0118 0.0893
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0007 0.0000000153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0092 0.0421 0.1114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus tyrosine kinase 0.0048 0.017 0.0347
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0025
Echinococcus multilocularis pyruvate kinase 0.0074 0.0321 0.0314
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0445 0.1176
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0018 0.0092
Echinococcus granulosus calcium activated potassium channel 0.002 0.0009 0.0004
Schistosoma mansoni glutamate receptor AMPA 0.0094 0.0431 0.0904
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0118 0.0893
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0044 0.0089
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.016 0.3503
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Echinococcus granulosus g protein coupled receptor 0.0029 0.0064 0.0121
Leishmania major pyruvate kinase 0.0074 0.0321 0.2791
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0251 0.1903
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0018 0.0092
Schistosoma mansoni glutamate receptor NMDA 0.063 0.3501 0.7449
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0024 0.0034 0.0086
Echinococcus granulosus g protein coupled receptor 0.0029 0.0064 0.0121
Brugia malayi sulfakinin receptor protein 0.0029 0.0064 0.0182
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0064 0.0057
Brugia malayi follicle stimulating hormone receptor 0.0519 0.2868 0.9161
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0584
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0024 0.0034 0.0215
Leishmania major hypothetical protein, conserved 0.0076 0.0333 0.2901
Echinococcus granulosus orexin receptor type 2 0.0029 0.0064 0.0121
Trypanosoma cruzi extracellular receptor, putative 0.0048 0.017 0.1448
Toxoplasma gondii pyruvate kinase PyKII 0.0038 0.0113 0.2432
Entamoeba histolytica hypothetical protein 0.0051 0.0187 0.1393
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.0488 0.4278
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0023 0.0045
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0095 0.0088
Loa Loa (eye worm) runx1 0.0055 0.0212 0.0552
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0085 0.0167
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0216 0.1131 0.3598
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0085 0.0698
Schistosoma mansoni opsin-like receptor 0.0029 0.0064 0.0121
Onchocerca volvulus 0.0029 0.0064 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0018 0.0134
Schistosoma mansoni hypothetical protein 0.0094 0.0431 0.0904
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0064 0.0121
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0044 0.0118
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0064 0.0057
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0064 0.0057
Echinococcus multilocularis Niemann Pick C1 protein 0.0214 0.1122 0.1116
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0085 0.0627
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0176 0.09 0.6832
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0007 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0064 0.0057
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0044 0.0118
Brugia malayi Guanylyl cyclase protein 23 0.0048 0.017 0.0521
Onchocerca volvulus 0.0029 0.0064 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0018 0.0134
Entamoeba histolytica hypothetical protein 0.0039 0.0117 0.0762
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0048 0.017 0.0439
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.0488 0.1025
Brugia malayi hypothetical protein 0.0049 0.0178 0.0547
Brugia malayi hypothetical protein 0.0039 0.0117 0.0354
Schistosoma mansoni cytochrome P450 0.0021 0.0018 0.0023
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0044 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0024 0.0034 0.0057
Brugia malayi ORL1-like opioid receptor 0.0029 0.0064 0.0182
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0023 0.0381
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.1149 0.8716
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0983 0.2082
Echinococcus granulosus low density lipoprotein receptor ldl 0.0057 0.0224 0.0463
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.0007 0.0002
Echinococcus multilocularis protein patched 0.0092 0.0421 0.0415
Echinococcus granulosus basement membrane specific heparan sulfate 0.0057 0.0224 0.0463
Schistosoma mansoni glutamate receptor kainate 0.0094 0.0431 0.0904
Onchocerca volvulus 0.0029 0.0064 0.0238
Onchocerca volvulus 0.0441 0.2422 1
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0034 0.0075
Leishmania major cytochrome p450-like protein 0.0021 0.0018 0.0096
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.016 0.0326
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0052
Mycobacterium ulcerans pyruvate kinase 0.0074 0.0321 0.2491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Mycobacterium tuberculosis Conserved protein 0.0039 0.0118 0.0893
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0018 0.0134
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0052
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0024 0.0034 0.0215
Plasmodium vivax pyruvate kinase, putative 0.0074 0.0321 0.7171
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0142 0.0705 0.1489
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0209 0.0203
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Brugia malayi hypothetical protein 0.0076 0.0333 0.1044
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0018 0.0134
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0024 0.0034 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0064 0.0057
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0018 0.0092
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0018 0.0134
Schistosoma mansoni lipoxygenase 0.0062 0.0253 0.0524
Brugia malayi hypothetical protein 0.0087 0.0391 0.123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0075
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) carboxylesterase 0.0023 0.0026 0.0052
Echinococcus granulosus RUN 0.0022 0.0023 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1258 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.007 0.0135
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0176 0.09 0.0894
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0018 0.0096
Onchocerca volvulus 0.0024 0.0034 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0421 0.3312
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0007 0.000000007182
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0075
Mycobacterium leprae Probable lipase LipE 0.0039 0.0118 0.0786
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0057 0.0224 0.0217
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0023 0.0026 0.015
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0023 0.0034
Loa Loa (eye worm) G protein alpha subunit 3 0.0024 0.0034 0.0075
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.0024 0.0054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0035 0.0089
Loa Loa (eye worm) voltage-gated calcium channel 0.002 0.0007 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0064 0.0121
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0171 0.035
Echinococcus granulosus Protein patched homolog 1 0.0092 0.0421 0.0884
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0695
Schistosoma mansoni glutamate receptor kainate 0.0094 0.0431 0.0904
Brugia malayi Pyruvate kinase, M2 isozyme 0.0074 0.0321 0.1004
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0118 0.0884
Echinococcus multilocularis nmda type glutamate receptor 0.0536 0.2965 0.296
Loa Loa (eye worm) pyruvate kinase 0.0074 0.0321 0.0843
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0024 0.0034 0.0215
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0018 0.0092
Onchocerca volvulus 0.0031 0.007 0.0265
Onchocerca volvulus 0.0024 0.0034 0.0114
Brugia malayi Glutamate receptor 2 precursor 0.0094 0.0431 0.1357
Brugia malayi Dopamine receptor protein 2 0.0029 0.0064 0.0182
Echinococcus granulosus transcription factor Dp 1 0.0125 0.061 0.1286
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0018 0.0096
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0023 0.0381
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0253 0.0246
Mycobacterium tuberculosis Probable reductase 0.0219 0.1149 0.8716
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0085 0.0698
Echinococcus granulosus pyruvate kinase 0.0038 0.0113 0.0227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0057 0.0224 0.0463
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0094 0.0431 0.0904
Loa Loa (eye worm) glutamate receptor 0.0048 0.017 0.0439
Schistosoma mansoni hypothetical protein 0.0089 0.0402 0.0843
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0024 0.0034 0.0215
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus multilocularis expressed conserved protein 0.0201 0.1047 0.1041
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0085 0.0698
Brugia malayi Serotonin receptor 0.0029 0.0064 0.0182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0052
Brugia malayi Thioredoxin reductase 0.0096 0.0445 0.1402
Onchocerca volvulus 0.0057 0.0224 0.0901
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0085 0.0698
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0085 0.0698
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0023 0.0026 0.004
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0165 0.0337
Schistosoma mansoni rab6-interacting 0.0022 0.0023 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0165 0.0337
Echinococcus multilocularis glutamate receptor 2 0.0142 0.0705 0.0699
Mycobacterium ulcerans carboxylesterase, LipT 0.0023 0.0026 0.0155
Schistosoma mansoni GTP-binding protein alpha subunit 0.0024 0.0034 0.0057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0018 0.0092
Mycobacterium ulcerans beta-lactamase 0.0039 0.0118 0.0884
Schistosoma mansoni amine GPCR 0.0029 0.0064 0.0121
Leishmania major cytochrome p450-like protein 0.0021 0.0018 0.0096
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0983 0.0977
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0216 0.1131 1
Giardia lamblia Pyruvate kinase 0.0074 0.0321 0.5846
Brugia malayi Calcium binding EGF domain containing protein 0.0057 0.0224 0.0695
Trichomonas vaginalis esterase, putative 0.0039 0.0118 0.0885
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0669 0.0663
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0064 0.0182
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0044 0.0327
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0024 0.0034 0.0057
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.0488 0.0481
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0216 0.1131 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0299
Schistosoma mansoni eyes absent homolog 0.0087 0.0391 0.0819
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0044 0.0298
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0695
Brugia malayi Carboxylesterase family protein 0.0023 0.0026 0.006
Echinococcus multilocularis Niemann Pick C1 protein 0.0306 0.1648 0.1642
Echinococcus granulosus glutamate receptor 2 0.0048 0.017 0.0347
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0294
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0671 0.3736 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0048 0.017 0.0163
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.024 0.1268 1
Loa Loa (eye worm) glutathione reductase 0.0096 0.0445 0.1176
Loa Loa (eye worm) hypothetical protein 0.0164 0.0832 0.2215
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.1149 0.8716
Brugia malayi RNA, U transporter 1 0.0179 0.0918 0.2917
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0018 0.0096
Schistosoma mansoni hypothetical protein 0.0089 0.0402 0.0843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0565 0.313 0.6658
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus carboxylesterase 5A 0.0135 0.0669 0.1411
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0333 0.2901
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0075
Onchocerca volvulus 0.0048 0.017 0.0676
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0519 0.2868 0.7673
Onchocerca volvulus Pyruvate kinase homolog 0.0074 0.0321 0.1301
Echinococcus multilocularis transcription factor Dp 1 0.0125 0.061 0.0604
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0052
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0064 0.0057
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0584
Echinococcus granulosus transient receptor potential cation channel 0.002 0.0007 0.0000000153
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0057 0.0224 0.0584
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0018 0.0134
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.016 0.349
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0117 0.0236
Onchocerca volvulus Pyruvate kinase homolog 0.0074 0.0321 0.1301
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0048 0.017 0.0163
Onchocerca volvulus 0.0039 0.0118 0.0461
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.0488 0.1992
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0118 0.0893
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0085 0.0698
Brugia malayi hypothetical protein 0.0259 0.1379 0.4393
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0255 0.0248
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.016 0.0153
Onchocerca volvulus 0.0023 0.0026 0.008
Brugia malayi hypothetical protein 0.0441 0.2422 0.7734
Echinococcus granulosus fmrfamide receptor 0.0029 0.0064 0.0121
Brugia malayi G-protein alpha subunit 0.0024 0.0034 0.0086
Echinococcus granulosus pyruvate kinase 0.0074 0.0321 0.0669
Echinococcus granulosus metabotropic glutamate receptor 5 0.0048 0.017 0.0347
Echinococcus multilocularis BC026374 protein (S09 family) 0.0023 0.0026 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Brugia malayi Carboxylesterase family protein 0.0023 0.0026 0.006
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0024 0.0034 0.0057
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0064 0.0057
Plasmodium falciparum glutathione reductase 0.0096 0.0445 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0064 0.0121
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Onchocerca volvulus 0.024 0.1267 0.5218
Brugia malayi GnHR receptor homolog 0.0029 0.0064 0.0182
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0064 0.0057
Echinococcus multilocularis pyruvate kinase 0.0074 0.0321 0.0314
Echinococcus granulosus expressed protein 0.0024 0.0034 0.0057
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.016 0.1847
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.002 0.0007 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0118 0.0985
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0064 0.0182
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0176 0.09 0.7085
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0018 0.0096
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0064 0.0121
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0216 0.1131 0.3015
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.0064 0.0238
Echinococcus granulosus tumor protein p63 0.0365 0.1985 0.4218
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0171 0.035
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0064 0.0182
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0064 0.0057
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.016 0.1359
Mycobacterium ulcerans hypothetical protein 0.0039 0.0118 0.0884
Mycobacterium leprae Probable pyruvate kinase PykA 0.0074 0.0321 0.2383
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0024 0.0034 0.0027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0075
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0057 0.0224 0.0217
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0118 0.0884
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0171 0.035
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0142 0.0705 0.1489
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0142 0.0705 0.0699
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0188 0.1449
Echinococcus granulosus sterol regulatory element binding protein 0.0092 0.0421 0.0884
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0216 0.1131 0.1125
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.017 0.0439
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0243 0.1289 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.054 0.1431
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0584
Schistosoma mansoni patched 1 0.0092 0.0421 0.0884
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0094 0.0431 0.0424
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0023 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0118 0.0893
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0024 0.0034 0.0057
Echinococcus multilocularis serotonin receptor 0.0029 0.0064 0.0057
Entamoeba histolytica hypothetical protein 0.0039 0.0117 0.0762
Onchocerca volvulus 0.0023 0.0026 0.008
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0064 0.0155
Schistosoma mansoni loxhd1 0.0022 0.0023 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0669 0.1412
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0024 0.0034 0.0027
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0018 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0075
Leishmania major extracellular receptor, putative 0.0048 0.017 0.1448
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0018 0.0096
Brugia malayi Carboxylesterase family protein 0.0023 0.0026 0.006
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0018 0.0134
Schistosoma mansoni glutamate receptor NMDA 0.0094 0.0431 0.0904
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0565 0.313 0.6658
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0018 0.0092
Echinococcus granulosus expressed conserved protein 0.0201 0.1047 0.2218
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0064 0.0155
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0064 0.0121
Onchocerca volvulus 0.0053 0.0201 0.0806
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.017 0.0347
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0057 0.0224 0.0463
Brugia malayi Metabotropic glutamate receptor precursor. 0.0048 0.017 0.0521
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0171 0.035
Onchocerca volvulus 0.0029 0.0064 0.0238
Loa Loa (eye worm) cytochrome P450 0.0021 0.0018 0.0031
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0034 0.0058
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0018 0.0092
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0006 0.0046
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0064 0.0121
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0064 0.0121
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0085 0.0628
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0187 0.1436
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0176 0.09 0.7951
Onchocerca volvulus 0.0029 0.0064 0.0238
Schistosoma mansoni hypothetical protein 0.0089 0.0402 0.0843
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0031 0.0051
Echinococcus granulosus metabotropic glutamate receptor 2 0.0048 0.017 0.0347
Echinococcus multilocularis cpg binding protein 0.0035 0.0096 0.0089
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0064 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0044 0.0327
Schistosoma mansoni adenoreceptor 0.0029 0.0064 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0044 0.0298
Schistosoma mansoni hypothetical protein 0.0838 0.4698 1
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0333 0.7452
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0024 0.0034 0.0086
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0024 0.0034 0.0057
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0085 0.0628
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0057 0.0224 0.0217
Plasmodium falciparum importin beta, putative 0.0063 0.0255 0.5669
Trypanosoma brucei polo-like protein kinase 0.0103 0.0488 0.4278
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0064 0.0121
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.017 0.0347
Loa Loa (eye worm) hypothetical protein 0.0074 0.0321 0.0843
Schistosoma mansoni opsin-like receptor 0.0029 0.0064 0.0121
Schistosoma mansoni cpg binding protein 0.0031 0.0075 0.0145
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0118 0.0885
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0488 0.1025
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0064 0.0121
Onchocerca volvulus 0.002 0.0007 0.0003
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0024 0.0034 0.0057
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0076 0.0333 0.0876
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0034 0.0058
Echinococcus multilocularis 0.0021 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0441 0.2422 0.6478
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0251 0.052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0075
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0255 0.2205
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0209 0.0432
Schistosoma mansoni cpg binding protein 0.0035 0.0096 0.019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0216 0.1131 0.2396
Brugia malayi basement membrane proteoglycan precursor 0.0057 0.0224 0.0695
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0218 0.0676
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0024 0.0034 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0085 0.0698
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0048 0.017 0.0521
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0216 0.1131 1
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0018 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0243 0.1289 0.9778
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0832 0.0826
Brugia malayi Niemann-Pick C1 protein precursor 0.0214 0.1122 0.357
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0256 0.5686
Onchocerca volvulus 0.0029 0.0064 0.0238
Schistosoma mansoni hypothetical protein 0.0022 0.0023 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0064 0.0121
Brugia malayi Bromodomain containing protein 0.0075 0.0323 0.1011
Echinococcus multilocularis pikachurin 0.0024 0.0034 0.0027
Trypanosoma brucei trypanothione reductase 0.0096 0.0445 0.3895
Echinococcus granulosus muscleblind protein 0.0164 0.0832 0.1759
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0333 0.1804 0.1799
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0565 0.313 0.6658
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0118 0.0985
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0064 0.0057
Schistosoma mansoni gliotactin 0.0023 0.0026 0.004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0142 0.0705 0.0699
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0064 0.0121
Schistosoma mansoni importin beta-1 0.0063 0.0255 0.0528
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0026 0.0195
Echinococcus multilocularis carboxylesterase 5A 0.0135 0.0669 0.0662
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0669 0.1778
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0333 0.2901
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Echinococcus multilocularis low density lipoprotein receptor protein 0.0057 0.0224 0.0217
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0044 0.0089
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0121
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0064 0.0057
Echinococcus granulosus atrial natriuretic peptide receptor 0.0048 0.017 0.0347
Echinococcus granulosus snurportin 1 0.0671 0.3736 0.7949
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0064 0.0121
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0031 0.0024
Plasmodium falciparum thioredoxin reductase 0.0096 0.0445 1
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Echinococcus granulosus pyruvate kinase 0.0074 0.0321 0.0669
Onchocerca volvulus 0.0057 0.0224 0.0901
Leishmania major pyruvate kinase 0.0074 0.0321 0.2791
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0216 0.1131 1
Entamoeba histolytica hypothetical protein 0.0039 0.0117 0.0762
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0018 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0064 0.0121
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0171 0.035
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0085 0.1809
Loa Loa (eye worm) hypothetical protein 0.0441 0.2422 0.6478
Brugia malayi Dopamine receptor protein 1 0.0029 0.0064 0.0182
Echinococcus multilocularis tyrosine kinase 0.0048 0.017 0.0163
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0085 0.0698
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0064 0.0182
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0064 0.0182
Brugia malayi Pre-SET motif family protein 0.0209 0.1093 0.3479
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0209 0.0432
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0057 0.0224 0.0695
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0283 0.059
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0018 0.0031
Toxoplasma gondii thioredoxin reductase 0.0096 0.0445 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0024 0.0034 0.0057
Schistosoma mansoni ran 0.0046 0.016 0.0326
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0024 0.0034 0.0057
Brugia malayi Bromodomain containing protein 0.0037 0.0108 0.0324
Loa Loa (eye worm) pyruvate kinase-PB 0.0052 0.0192 0.0498
Schistosoma mansoni glutamate receptor kainate 0.0094 0.0431 0.0904
Schistosoma mansoni pyruvate kinase 0.0074 0.0321 0.0669
Onchocerca volvulus 0.0029 0.0064 0.0238
Echinococcus multilocularis para nitrobenzyl esterase 0.0023 0.0026 0.0019
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0044 0.0298
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0695
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0299
Onchocerca volvulus 0.0053 0.0198 0.0792
Onchocerca volvulus 0.0022 0.0023 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0669 0.1412
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0024 0.0034 0.0215
Brugia malayi beta-lactamase 0.0039 0.0118 0.0355
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.0007 0.0002
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0695
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0488 0.3841
Echinococcus granulosus cpg binding protein 0.0035 0.0096 0.019
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0064 0.0121
Schistosoma mansoni hypothetical protein 0.0293 0.1574 0.3341
Mycobacterium ulcerans lipase LipD 0.0039 0.0118 0.0884
Schistosoma mansoni pyruvate kinase 0.0074 0.0321 0.0669
Mycobacterium tuberculosis Conserved protein 0.0039 0.0118 0.0893
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0044 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0101
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0064 0.0057
Schistosoma mansoni biogenic amine receptor 0.0029 0.0064 0.0121
Onchocerca volvulus 0.0023 0.0026 0.008
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0165 0.0337
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.0488 0.1539
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0094 0.0431 0.0424
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0018 0.0134
Brugia malayi hypothetical protein 0.0029 0.0064 0.0182
Trypanosoma cruzi pyruvate kinase 2, putative 0.0074 0.0321 0.2791
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0018 0.0096
Echinococcus granulosus geminin 0.0838 0.4698 1
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0064 0.0057
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0064 0.0057
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0064 0.0155
Echinococcus multilocularis serotonin receptor 0.0029 0.0064 0.0057
Echinococcus multilocularis sex peptide receptor 0.0029 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.0439
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0064 0.0121
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0057 0.0224 0.0463
Brugia malayi Doublecortin family protein 0.0022 0.0023 0.0051
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0023 0.0026 0.0019
Echinococcus multilocularis somatostatin receptor 0.0029 0.0064 0.0057
Brugia malayi mbt repeat family protein 0.0048 0.0171 0.0526
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0142 0.0705 0.0699
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.024 0.1268 0.9624
Plasmodium vivax pyruvate kinase 2, putative 0.0038 0.0113 0.2447
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0118 0.0236
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0057 0.0224 0.0584
Brugia malayi Muscleblind-like protein 0.0164 0.0832 0.2643
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0118 0.0985
Echinococcus granulosus glutamate receptor subunit protein glur 0.0094 0.0431 0.0904
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0488 0.3841
Schistosoma mansoni myosin xvIII 0.0029 0.0064 0.0121
Echinococcus granulosus tar DNA binding protein 0.0135 0.0669 0.1412
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0064 0.0121
Brugia malayi beta-lactamase family protein 0.0039 0.0118 0.0355
Schistosoma mansoni hypothetical protein 0.0039 0.0116 0.0232
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0085 0.0628
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0064 0.0121
Brugia malayi Pre-SET motif family protein 0.0031 0.007 0.0203
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0445 0.3895
Brugia malayi hypothetical protein 0.0023 0.0026 0.006
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0057 0.0224 0.0463
Schistosoma mansoni amine GPCR 0.0029 0.0064 0.0121
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0044 0.0327
Leishmania major hypothetical protein, conserved 0.0039 0.0118 0.0985
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0117 0.0236
Plasmodium falciparum thioredoxin reductase 0.0033 0.0085 0.1809
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0057 0.0224 0.0217
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0085 0.0251
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Schistosoma mansoni kinase 0.0053 0.0196 0.0403
Echinococcus multilocularis muscleblind protein 0.0164 0.0832 0.0826
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0085 0.0698
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0171 0.0682
Loa Loa (eye worm) hypothetical protein 0.0048 0.0171 0.0443
Brugia malayi EGF-like domain containing protein 0.0026 0.0042 0.0113
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0118 0.0893
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Onchocerca volvulus 0.0057 0.0224 0.0901
Schistosoma mansoni cpg binding protein 0.0035 0.0096 0.019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0565 0.313 0.8376
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.007 0.0135
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0085 0.0648
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0094 0.0431 0.0424
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0085 0.0627
Brugia malayi Melatonin receptor type 1A 0.0029 0.0064 0.0182
Trichomonas vaginalis spcc417.12 protein, putative 0.0023 0.0026 0.015
Schistosoma mansoni cell polarity protein 0.0024 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Mycobacterium tuberculosis Conserved protein 0.0039 0.0118 0.0893
Schistosoma mansoni pyruvate kinase 0.0038 0.0113 0.0227
Toxoplasma gondii pyruvate kinase PyK1 0.0074 0.0321 0.7166
Brugia malayi Glutamate receptor 1 precursor 0.0094 0.0431 0.1357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0064 0.0121
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0044 0.0204
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0218 0.0569
Onchocerca volvulus 0.0029 0.0064 0.0238
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0299
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0118 0.0885
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0023 0.0034
Onchocerca volvulus 0.0048 0.0171 0.0682
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0024 0.0034 0.0057
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0064 0.0121
Plasmodium falciparum pyruvate kinase 2 0.0038 0.0113 0.2447
Brugia malayi G-protein coupled receptor 0.0029 0.0064 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.0488 0.1291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0064 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0044 0.0298
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0044 0.0204
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0024 0.0034 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0044 0.0089
Onchocerca volvulus 0.0029 0.0064 0.0238
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0064 0.0121
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0034 0.0058
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0255 0.2205
Echinococcus granulosus low density lipoprotein receptor ldl 0.0057 0.0224 0.0463
Echinococcus granulosus importin subunit beta 1 0.0063 0.0255 0.0528
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0121
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0024 0.0034 0.0027
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0023 0.0016
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0018 0.0092
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0201 0.0413
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.016 0.1359
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0488 0.3841
Brugia malayi Carboxylesterase family protein 0.0023 0.0026 0.006
Echinococcus granulosus pyruvate kinase 0.0038 0.0113 0.0227
Onchocerca volvulus 0.0029 0.0064 0.0238
Leishmania major trypanothione reductase 0.0096 0.0445 0.3895
Loa Loa (eye worm) hypothetical protein 0.0052 0.0192 0.0498
Echinococcus granulosus receptor type guanylyl cyclase 0.0048 0.017 0.0347
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0118 0.0786
Schistosoma mansoni bromodomain containing protein 0.0063 0.0257 0.0534
Brugia malayi CHE-14 protein 0.0092 0.0421 0.1327
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0171 0.0443
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0024 0.0034 0.0075
Echinococcus granulosus serotonin receptor 0.0029 0.0064 0.0121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0366
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0064 0.0057
Echinococcus multilocularis protein dispatched 1 0.0105 0.0496 0.0489
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0064 0.0121
Brugia malayi cytochrome P450 0.0021 0.0018 0.0035
Schistosoma mansoni ran 0.0046 0.016 0.0326
Echinococcus multilocularis acetylcholinesterase 0.0135 0.0669 0.0662
Loa Loa (eye worm) hypothetical protein 0.0135 0.0669 0.1777
Loa Loa (eye worm) pyruvate kinase 0.0074 0.0321 0.0843
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0176 0.09 0.1905
Onchocerca volvulus 0.0048 0.017 0.0676
Brugia malayi Carboxylesterase family protein 0.0135 0.0669 0.2119
Mycobacterium tuberculosis Probable oxidoreductase 0.0243 0.1289 0.9778
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0085 0.5
Onchocerca volvulus 0.0057 0.0224 0.0901
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0064 0.0057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0002
Onchocerca volvulus 0.0029 0.0064 0.0238
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0057 0.0224 0.0217
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0209 0.0203
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0024 0.0034 0.0215
Entamoeba histolytica hypothetical protein 0.0048 0.017 0.1238
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0064 0.0057

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 13.85 nM In vitro cytotoxicity against human leukemia CCRF-CEM tumor cell lines ChEMBL. 10411479
IC50 (functional) = 13.85 nM In vitro cytotoxicity against human leukemia CCRF-CEM tumor cell lines ChEMBL. 10411479
IC50 (functional) = 14 nM In vitro growth inhibitory activity in the human CCRF-CEM leukemia cell line. ChEMBL. 12825938
IC50 (functional) = 14 nM In vitro growth inhibitory activity in the human CCRF-CEM leukemia cell line. ChEMBL. 12825938

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10411479

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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