Detailed information for compound 149819

Basic information

Technical information
  • TDR Targets ID: 149819
  • Name: (3S,6R,7S)-3-N-[2-(2,4-difluoroanilino)-2-oxo ethyl]-7-N-hydroxy-6-(2-methylpropyl)-5-oxo-1 1-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(1 6),13-triene-3,7-dicarboxamide
  • MW: 560.59 | Formula: C28H34F2N4O6
  • H donors: 5 H acceptors: 5 LogP: 2.89 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: ONC(=O)[C@H]1CCCOc2ccc(C[C@H](NC(=O)[C@@H]1CC(C)C)C(=O)NCC(=O)Nc1ccc(cc1F)F)cc2
  • InChi: 1S/C28H34F2N4O6/c1-16(2)12-21-20(27(37)34-39)4-3-11-40-19-8-5-17(6-9-19)13-24(33-26(21)36)28(38)31-15-25(35)32-23-10-7-18(29)14-22(23)30/h5-10,14,16,20-21,24,39H,3-4,11-13,15H2,1-2H3,(H,31,38)(H,32,35)(H,33,36)(H,34,37)/t20-,21+,24-/m0/s1
  • InChiKey: CZDLRFFDOLPTCL-IMSXRSKXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S,6R,7S)-N-[2-(2,4-difluoroanilino)-2-oxo-ethyl]-7-(hydroxycarbamoyl)-6-isobutyl-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3-carboxamide
  • (3S,6R,7S)-N-[2-(2,4-difluoroanilino)-2-oxoethyl]-7-[(hydroxyamino)-oxomethyl]-6-isobutyl-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3-carboxamide
  • (3S,6R,7S)-N3-[2-[(2,4-difluorophenyl)amino]-2-oxo-ethyl]-N7-hydroxy-6-(2-methylpropyl)-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3,7-dicarboxamide
  • (3S,6R,7S)-N-[2-(2,4-difluoroanilino)-2-keto-ethyl]-7-(hydroxycarbamoyl)-6-isobutyl-5-keto-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3-carboxamide
  • (3S,6R,7S)-N-[2-[(2,4-difluorophenyl)amino]-2-oxoethyl]-N'-hydroxy-6-(2-methylpropyl)-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3,7-dicarboxamide
  • (3S,6R,7S)-N-[2-[(2,4-difluorophenyl)amino]-2-oxo-ethyl]-7-(hydroxycarbamoyl)-6-isobutyl-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3-carboxamide
  • (3S,6R,7S)-N-[2-[(2,4-difluorophenyl)amino]-2-oxoethyl]-7-[(hydroxyamino)-oxomethyl]-6-isobutyl-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3-carboxamide
  • (3S,6R,7S)-N-[2-[(2,4-difluorophenyl)amino]-2-keto-ethyl]-7-(hydroxycarbamoyl)-6-isobutyl-5-keto-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3-carboxamide
  • (3S,6R,7S)-N-[2-[(2,4-difluorophenyl)amino]-2-oxo-ethyl]-N'-hydroxy-6-(2-methylpropyl)-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3,7-dicarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ADAM metallopeptidase domain 17 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus Blood coagulation inhibitor Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma mansoni ADAM17 peptidase (M12 family) Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma japonicum ko:K06059 a disintegrin and metalloproteinase domain 17, putative Get druggable targets OG5_132656 All targets in OG5_132656
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Disintegrin family protein ADAM metallopeptidase domain 17 824 aa 724 aa 27.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 3 0.0243 0.002 0.002
Echinococcus granulosus retinal guanylyl cyclase 2 0.0252 0.003 0.003
Schistosoma mansoni tyrosine kinase 0.0812 0.0601 0.162
Entamoeba histolytica protein kinase, putative 0.0769 0.0557 0.5674
Echinococcus granulosus serine threonine protein kinase nrc 0.0325 0.0104 0.0104
Schistosoma mansoni adapter molecule crk 0.0399 0.018 0.0485
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0593 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.056 0.0344 0.0344
Loa Loa (eye worm) TK/DDR protein kinase 0.0404 0.0185 0.0185
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0325 0.0104 0.0987
Trichomonas vaginalis AGC family protein kinase 0.0769 0.0557 0.5319
Brugia malayi Protein kinase domain containing protein 0.1169 0.0965 0.0965
Leishmania major protein kinase, putative 0.1117 0.0912 0.0905
Schistosoma mansoni growth factor receptor-bound protein 0.0415 0.0196 0.0529
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.1145 0.0941 0.0941
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Echinococcus granulosus cyclin dependent kinase 1 0.0519 0.0302 0.0302
Entamoeba histolytica hypothetical protein 0.0252 0.003 0.0303
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0252 0.003 0.0303
Echinococcus granulosus protein kinase c epsilon type 0.0741 0.0528 0.0528
Loa Loa (eye worm) TK/ABL protein kinase 0.2292 0.2112 0.2112
Echinococcus multilocularis dual specificity mitogen activated protein 0.1242 0.104 0.104
Schistosoma mansoni serine/threonine kinase 0.0496 0.0279 0.0751
Brugia malayi Protein kinase domain containing protein 0.0825 0.0615 0.0615
Echinococcus multilocularis N chimaerin 0.0379 0.0159 0.0159
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1403 0.1204 0.1204
Plasmodium vivax protein kinase Crk2 0.0519 0.0302 0.3024
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 1.0022 1 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.1102 0.0897 0.0897
Loa Loa (eye worm) hypothetical protein 0.0398 0.0179 0.0179
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.1242 0.104 0.1033
Entamoeba histolytica protein kinase, putative 0.0769 0.0557 0.5674
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.04 0.018 0.018
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1184 0.0981 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0519 0.0302 0.3024
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0784 0.0572 0.0572
Schistosoma mansoni tyrosine kinase 0.0493 0.0276 0.0743
Echinococcus granulosus tyrosine protein kinase shark 0.0716 0.0503 0.0503
Echinococcus granulosus mitogen activated protein kinase 11 1.0022 1 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0274 0.0052 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0519 0.0302 0.0814
Echinococcus multilocularis expressed conserved protein 0.03 0.0079 0.0079
Loa Loa (eye worm) RGC/RGC protein kinase 0.0252 0.003 0.003
Echinococcus granulosus mitogen activated protein kinase 0.0243 0.002 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0389 0.0169 0.0456
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.076 0.0548 0.0548
Loa Loa (eye worm) TK/EGFR protein kinase 0.1044 0.0837 0.0837
Loa Loa (eye worm) hypothetical protein 0.0931 0.0723 0.0723
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.248 0.2304 0.2304
Echinococcus granulosus casein kinase I delta 0.0644 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0757 0.0545 0.0545
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0437 0.0219 0.0211
Trypanosoma cruzi polo-like protein kinase, putative 0.0346 0.0126 0.0118
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0305 0.0084 0.0076
Entamoeba histolytica hypothetical protein 0.0252 0.003 0.0303
Echinococcus granulosus protein kinase 0.0979 0.0772 0.0772
Entamoeba histolytica protein kinase, putative 0.0421 0.0202 0.2057
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0707 0.0494 0.133
Trypanosoma cruzi Protein kinase B 0.037 0.015 0.0143
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1453 0.1255 0.1255
Echinococcus granulosus neuroglian 0.0309 0.0088 0.0088
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Echinococcus granulosus tyrosine protein kinase Src42A 0.1103 0.0898 0.0898
Trypanosoma brucei casein kinase I, isoform 2 0.0644 0.043 0.0422
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0252 0.003 0.008
Echinococcus multilocularis dual specificity 0.0305 0.0084 0.0084
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0892 0.0683 0.0683
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1453 0.1255 0.1255
Echinococcus granulosus retinal guanylyl cyclase 2 0.0252 0.003 0.003
Echinococcus granulosus NCK adaptor protein 0.0399 0.018 0.018
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.1169 0.0965 0.0965
Echinococcus granulosus epidermal growth factor receptor 0.0887 0.0678 0.0678
Echinococcus granulosus ephrin type A receptor 4 A 0.0324 0.0103 0.0103
Echinococcus multilocularis activin receptor type 0.4053 0.3909 0.3909
Echinococcus multilocularis PAK box P21 Rho binding 0.0375 0.0155 0.0155
Brugia malayi Fes/CIP4 homology domain containing protein 0.0893 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Entamoeba histolytica PH domain containing protein kinase, putative 0.0231 0.0008 0.0079
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0398 0.0179 0.0171
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0268 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0255 0.0033 0.0334
Plasmodium vivax calcium-dependent protein kinase, putative 0.0577 0.0361 0.363
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.076 0.0548 0.054
Echinococcus granulosus roundabout 2 0.0309 0.0088 0.0088
Loa Loa (eye worm) CAMK/PKD protein kinase 0.095 0.0742 0.0742
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0252 0.003 0.003
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0439 0.0221 0.0221
Echinococcus multilocularis receptor type guanylyl cyclase 0.0252 0.003 0.003
Brugia malayi protein kinase C3,putative 0.0435 0.0216 0.0216
Giardia lamblia Kinase, STE STE20 0.0244 0.0021 0.0018
Echinococcus granulosus tyrosine protein kinase csk 0.0252 0.003 0.003
Trichomonas vaginalis AGC family protein kinase 0.024 0.0017 0.0092
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0625 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0252 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0255 0.0033 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.0368 0.0148 0.1354
Loa Loa (eye worm) hypothetical protein 0.0765 0.0553 0.0553
Brugia malayi intracellular kinase 0.1184 0.0981 0.0981
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.0126 0.1143
Plasmodium vivax tyrosine kinase-like protein, putative 0.0252 0.003 0.0225
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0625 0.0411 0.4138
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Schistosoma mansoni tyrosine kinase 0.0651 0.0437 0.1178
Entamoeba histolytica hypothetical protein 0.0252 0.003 0.0303
Onchocerca volvulus 0.0475 0.0257 0.0385
Entamoeba histolytica protein kinase, putative 0.1169 0.0965 0.9839
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0583 0.0368 0.0368
Echinococcus granulosus twitchin 0.0989 0.0782 0.0782
Echinococcus multilocularis rho associated protein kinase 0.0836 0.0626 0.0626
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 1.0022 1 1
Loa Loa (eye worm) hypothetical protein 0.062 0.0405 0.0405
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0274 0.0052 0.0052
Trypanosoma brucei cdc2-related kinase 3 0.0519 0.0302 0.0295
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Schistosoma mansoni protein kinase 0.0252 0.003 0.008
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0379 0.0159 0.0428
Loa Loa (eye worm) hypothetical protein 0.0765 0.0553 0.0553
Loa Loa (eye worm) TK protein kinase 0.0252 0.003 0.003
Toxoplasma gondii aurora kinase 0.0625 0.0411 0.4138
Echinococcus multilocularis casein kinase ii subunit alpha 0.0261 0.0039 0.0039
Schistosoma mansoni protein kinase 0.0375 0.0155 0.0419
Schistosoma mansoni cell adhesion molecule 0.0309 0.0088 0.0236
Echinococcus multilocularis tyrosine protein kinase Abl 0.1346 0.1146 0.1146
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0252 0.003 0.003
Onchocerca volvulus 0.0475 0.0257 0.0385
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0379 0.0159 0.0428
Giardia lamblia Kinase, CMGC MAPK 0.0243 0.002 0.0007
Echinococcus granulosus cGMP dependent protein kinase 1 0.03 0.0079 0.0079
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0441 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.4337 0.4198 0.4198
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0577 0.0361 0.0361
Trichomonas vaginalis CMGC family protein kinase 0.0519 0.0302 0.2852
Schistosoma mansoni titin 0.0407 0.0188 0.0506
Schistosoma mansoni tyrosine kinase 0.1454 0.1256 0.3384
Echinococcus multilocularis calcium dependent protein kinase 0.0392 0.0172 0.0172
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.3097 0.2933 0.2933
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.1117 0.0912 0.0905
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Echinococcus multilocularis aurora kinase A 0.0625 0.0411 0.0411
Echinococcus multilocularis tyrosine kinase 0.0252 0.003 0.003
Onchocerca volvulus 0.0268 0.0046 0.0069
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0302 0.008 0.0745
Echinococcus granulosus tyrosine protein kinase Fyn 0.1103 0.0898 0.0898
Echinococcus multilocularis serine:threonine protein kinase 38 0.0583 0.0368 0.0368
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0385 0.0165 0.0165
Loa Loa (eye worm) TK/INSR protein kinase 0.1368 0.1169 0.1169
Onchocerca volvulus 0.0644 0.043 0.0643
Plasmodium falciparum protein kinase 5 0.0519 0.0302 0.3024
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0325 0.0104 0.0987
Trichomonas vaginalis AGC family protein kinase 0.0618 0.0404 0.3835
Trypanosoma cruzi casein kinase, putative 0.0644 0.043 0.0422
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0039 0.03
Brugia malayi Peroxidasin 0.0277 0.0056 0.0056
Entamoeba histolytica protein kinase domain containing protein 0.03 0.0079 0.0803
Brugia malayi Protein kinase domain containing protein 0.0461 0.0243 0.0243
Entamoeba histolytica hypothetical protein 0.0255 0.0033 0.0334
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.076 0.0548 0.0548
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0577 0.0361 0.0361
Echinococcus multilocularis roundabout 2 0.0925 0.0717 0.0717
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0252 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1103 0.0898 0.0898
Onchocerca volvulus 0.0475 0.0257 0.0385
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0333 0.0113 0.0113
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Leishmania major protein kinase A catalytic subunit 0.076 0.0548 0.054
Brugia malayi Protein kinase domain containing protein 0.0654 0.044 0.044
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0333 0.0113 0.0113
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0577 0.0361 0.363
Onchocerca volvulus 0.0765 0.0553 0.0828
Echinococcus multilocularis mitogen activated protein kinase 0.0243 0.002 0.002
Trichomonas vaginalis AGC family protein kinase 0.0769 0.0557 0.5319
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0252 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.051 0.0293 0.0293
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0651 0.0437 0.1178
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0252 0.003 0.003
Brugia malayi hypothetical protein 0.3097 0.2933 0.2933
Echinococcus granulosus cyclin dependent kinase 0.0519 0.0302 0.0302
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0551 0.0335 0.0335
Trichomonas vaginalis STE family protein kinase 0.0252 0.003 0.0212
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0261 0.0039 0.0318
Echinococcus multilocularis tyrosine protein kinase csk 0.0252 0.003 0.003
Echinococcus granulosus titin 0.0407 0.0188 0.0188
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis STE family protein kinase 0.04 0.018 0.1672
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0459 0.0241 0.0241
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Schistosoma mansoni protein kinase 0.096 0.0752 0.2027
Plasmodium falciparum protein kinase, putative 0.0252 0.003 0.0225
Echinococcus multilocularis raf serine:threonine protein kinase 0.0408 0.0189 0.0189
Loa Loa (eye worm) CMGC/CLK protein kinase 0.1117 0.0912 0.0912
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0704 0.049 0.049
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Entamoeba histolytica protein kinase domain containing protein 0.0261 0.0039 0.0395
Leishmania major protein kinase, putative 0.0577 0.0361 0.0354
Entamoeba histolytica protein kinase domain containing protein 0.0437 0.0219 0.2228
Schistosoma mansoni protein kinase 0.0366 0.0146 0.0392
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0494 0.0277 0.0277
Entamoeba histolytica protein kinase, putative 0.0305 0.0084 0.0852
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1453 0.1255 0.1255
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Schistosoma mansoni tyrosine kinase 0.0635 0.042 0.1132
Echinococcus multilocularis cGMP dependent protein kinase 1 0.03 0.0079 0.0079
Echinococcus granulosus Vam6:Vps39 protein 0.0707 0.0494 0.0494
Onchocerca volvulus 0.0836 0.0626 0.0936
Schistosoma mansoni cell adhesion molecule 0.0274 0.0052 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0398 0.0179 0.0482
Brugia malayi Protein kinase domain containing protein 0.248 0.2304 0.2304
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0893 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0947 0.0739 0.0739
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0789 0.0578 0.0578
Echinococcus multilocularis tyrosine protein kinase csk 0.0252 0.003 0.003
Entamoeba histolytica casein kinase, putative 0.0644 0.043 0.4378
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1103 0.0898 0.0898
Loa Loa (eye worm) hypothetical protein 0.0252 0.003 0.003
Echinococcus multilocularis heat shock protein 70 0.0252 0.003 0.003
Schistosoma mansoni vav2 0.0424 0.0205 0.0553
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0785 0.0574 0.0574
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0243 0.002 0.0012
Echinococcus granulosus dual specificity 0.1169 0.0965 0.0965
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0252 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.1145 0.0941 0.0941
Brugia malayi protein C17H12.11 0.0604 0.0389 0.0389
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.0126 0.1143
Trichomonas vaginalis STE family protein kinase 0.04 0.018 0.1672
Brugia malayi protein kinase C II. 0.0741 0.0528 0.0528
Schistosoma mansoni serine/threonine protein kinase 0.0593 0.0378 0.1017
Loa Loa (eye worm) TK protein kinase 0.0252 0.003 0.003
Trichomonas vaginalis STE family protein kinase 0.1242 0.104 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0408 0.0189 0.0189
Entamoeba histolytica protein kinase, putative 0.0723 0.051 0.5202
Brugia malayi serine/threonine-protein kinase PAK 7 0.2219 0.2037 0.2037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0577 0.0361 0.0361
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) TK/ROR protein kinase 0.0439 0.0221 0.0221
Echinococcus multilocularis lachesin 0.0274 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.076 0.0548 0.1475
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0577 0.0361 0.0361
Loa Loa (eye worm) AGC/NDR protein kinase 0.0583 0.0368 0.0368
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0231 0.0009 0.0009
Giardia lamblia Kinase, CMGC CDK 0.0519 0.0302 0.2772
Onchocerca volvulus 0.0407 0.0188 0.0281
Trypanosoma cruzi rac serine-threonine kinase, putative 0.037 0.015 0.0143
Onchocerca volvulus 0.0921 0.0712 0.1065
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Entamoeba histolytica protein kinase, putative 0.0231 0.0008 0.0079
Echinococcus multilocularis mitogen activated protein kinase 11 1.0022 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0325 0.0104 0.0096
Echinococcus granulosus tyrosine protein kinase Fyn 0.1103 0.0898 0.0898
Loa Loa (eye worm) TK protein kinase 0.0252 0.003 0.003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Loa Loa (eye worm) TK/FAK protein kinase 0.3903 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.077 0.0558 0.0558
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0309 0.0088 0.0088
Entamoeba histolytica protein kinase, putative 0.0255 0.0033 0.0334
Trypanosoma cruzi casein kinase, putative 0.0644 0.043 0.0422
Echinococcus granulosus cyclin dependent kinase 9 0.0385 0.0165 0.0165
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Schistosoma mansoni serine/threonine protein kinase 0.03 0.0079 0.0212
Trypanosoma cruzi casein kinase II, putative 0.0261 0.0039 0.0031
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0252 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0255 0.0032 0.033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0577 0.0361 0.0361
Loa Loa (eye worm) TK protein kinase 0.1641 0.1447 0.1447
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.2536 0.236 0.236
Echinococcus multilocularis protein tyrosine kinase 0.386 0.3712 0.3712
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0238 0.0015 0.0072
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Echinococcus granulosus serine:threonine kinase SAD 1 0.0398 0.0179 0.0179
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.076 0.0548 0.0548
Trichomonas vaginalis AGC family protein kinase 0.0252 0.003 0.0212
Echinococcus granulosus NDR protein kinase 0.0583 0.0368 0.0368
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0252 0.003 0.003
Entamoeba histolytica cell division protein kinase 2, putative 0.0519 0.0302 0.308
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) hypothetical protein 0.0891 0.0682 0.0682
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0243 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0342 0.0121 0.0121
Schistosoma mansoni protein kinase 0.0644 0.043 0.1157
Echinococcus multilocularis protein kinase c iota type 0.0833 0.0622 0.0622
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1453 0.1255 0.1255
Giardia lamblia Protein 21.1 0.0252 0.003 0.0103
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0437 0.0219 0.0219
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.076 0.0548 0.5545
Schistosoma mansoni growth factor receptor-bound protein 0.0399 0.018 0.0485
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Trichomonas vaginalis AGC family protein kinase 0.0625 0.0411 0.3903
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Schistosoma mansoni protein kinase 0.0893 0.0684 0.1843
Plasmodium vivax serine/threonine protein kinase, putative 0.0242 0.0019 0.0117
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0252 0.003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0277 0.0056 0.0056
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi MAP kinase sur-1 0.0243 0.002 0.002
Echinococcus granulosus casein kinase I delta 0.0644 0.043 0.043
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Entamoeba histolytica casein kinase, putative 0.0261 0.0039 0.0395
Loa Loa (eye worm) TKL/LRRK protein kinase 0.051 0.0293 0.0293
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Loa Loa (eye worm) hypothetical protein 0.0812 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0252 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Entamoeba histolytica protein kinase domain containing protein 0.0625 0.0411 0.4184
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0551 0.0335 0.0335
Trichomonas vaginalis AGC family protein kinase 0.076 0.0548 0.523
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0574 0.0359 0.0359
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0577 0.0361 0.0361
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0707 0.0494 0.133
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0305 0.0084 0.0778
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0887 0.0678 0.0678
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.076 0.0548 0.054
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Schistosoma mansoni protein kinase 0.0979 0.0772 0.2079
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.003 0.0212
Entamoeba histolytica serine/threonine protein kinase, putative 0.0398 0.0179 0.1823
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0577 0.0361 0.0361
Loa Loa (eye worm) TK protein kinase 0.0927 0.0719 0.0719
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trypanosoma brucei rac serine-threonine kinase, putative 0.0769 0.0557 0.0549
Entamoeba histolytica protein kinase, putative 0.024 0.0017 0.0177
Onchocerca volvulus Slit protein homolog 0.0271 0.0049 0.0074
Brugia malayi Protein kinase domain containing protein 0.0426 0.0207 0.0207
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Schistosoma mansoni protein kinase 0.0252 0.003 0.008
Echinococcus multilocularis serine:threonine protein kinase N2 0.0583 0.0368 0.0368
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0039 0.03
Schistosoma mansoni protein kinase 0.0437 0.0219 0.0589
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.04 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0271 0.0049 0.0049
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0437 0.0219 0.0211
Echinococcus multilocularis neuroglian 0.0804 0.0593 0.0593
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0519 0.0302 0.0295
Echinococcus granulosus tyrosine kinase 0.0252 0.003 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0252 0.003 0.003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.1117 0.0912 0.0905
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0305 0.0084 0.0076
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1184 0.0981 0.0981
Loa Loa (eye worm) TK/FER protein kinase 0.0252 0.003 0.003
Echinococcus multilocularis expressed protein 0.0242 0.0019 0.0019
Echinococcus multilocularis serine:threonine protein kinase 0.0368 0.0148 0.0148
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) gastrulation defective protein 1 0.1586 0.1391 0.1391
Brugia malayi Receptor family ligand binding region containing protein 0.0252 0.003 0.003
Echinococcus multilocularis protein KINase family member (kin 25) 0.0812 0.0601 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.003 0.0212
Loa Loa (eye worm) hypothetical protein 0.0984 0.0776 0.0776
Toxoplasma gondii hypothetical protein 0.0757 0.0545 0.5523
Loa Loa (eye worm) TK protein kinase 0.0595 0.0379 0.0379
Entamoeba histolytica protein kinase, putative 0.0625 0.0411 0.4184
Echinococcus multilocularis mitogen activated protein kinase 11 1.0022 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0369 0.0149 0.04
Schistosoma mansoni serine/threonine protein kinase 0.0369 0.0149 0.04
Leishmania major protein kinase, putative 0.0252 0.003 0.0022
Trypanosoma cruzi cdc2-related kinase 1 0.0519 0.0302 0.0295
Schistosoma mansoni protein kinase 0.04 0.018 0.0486
Loa Loa (eye worm) hypothetical protein 0.0404 0.0185 0.0185
Echinococcus granulosus cyclin dependent kinase 7 0.061 0.0395 0.0395
Echinococcus granulosus Immunoglobulin 0.0616 0.0402 0.0402
Loa Loa (eye worm) protein kinase domain-containing protein 0.0252 0.003 0.003
Plasmodium vivax glycogen synthase kinase 3, putative 0.1184 0.0981 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0252 0.003 0.0212
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2296 0.2116 0.2116
Echinococcus granulosus dual specificity 0.0305 0.0084 0.0084
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1593 0.1399 0.1399
Echinococcus granulosus tyrosine protein kinase Src64B 0.1103 0.0898 0.0898
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0244 0.0021 0.0214
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0252 0.003 0.003
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0644 0.043 0.043
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0326 0.0105 0.0105
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Brugia malayi Serine/threonine-protein kinase Pim-3 0.2296 0.2116 0.2116
Entamoeba histolytica protein kinase, putative 0.0577 0.0361 0.3681
Onchocerca volvulus 0.077 0.0558 0.0835
Plasmodium vivax tyrosine kinase-like protein, putative 0.0239 0.0017 0.0092
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0398 0.0179 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.1102 0.0897 0.2417
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Echinococcus granulosus roundabout 2 0.0309 0.0088 0.0088
Brugia malayi Protein kinase domain containing protein 0.4932 0.4806 0.4806
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Onchocerca volvulus 0.0252 0.003 0.0044
Echinococcus multilocularis titin 0.0407 0.0188 0.0188
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.1242 0.104 0.104
Schistosoma mansoni serine/threonine protein kinase 0.0583 0.0368 0.0991
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Brugia malayi Immunoglobulin I-set domain containing protein 0.0407 0.0188 0.0188
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1959 0.1772 0.1772
Entamoeba histolytica protein kinase, putative 0.0231 0.0008 0.0079
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0459 0.0241 0.0233
Plasmodium falciparum serine/threonine protein kinase 0.0242 0.0019 0.0117
Trypanosoma brucei SNF1-related protein kinases, putative 0.0398 0.0179 0.0171
Schistosoma mansoni protein kinase 0.0252 0.003 0.008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1103 0.0898 0.0898
Loa Loa (eye worm) hypothetical protein 0.0274 0.0052 0.0052
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Onchocerca volvulus 0.0376 0.0156 0.0234
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1959 0.1772 0.1772
Echinococcus multilocularis NCK adaptor protein 0.0415 0.0196 0.0196
Echinococcus granulosus serine:threonine protein kinase 0.0368 0.0148 0.0148
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0707 0.0494 0.0486
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0261 0.0039 0.0039
Echinococcus granulosus casein kinase i 0.0644 0.043 0.043
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0433 0.0215 0.2124
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0398 0.0179 0.0179
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.248 0.2304 0.2304
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Brugia malayi hypothetical protein 0.0252 0.003 0.003
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1103 0.0898 0.0898
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus multilocularis transfer RNA-Thr 0.1707 0.1514 0.1514
Echinococcus multilocularis death associated protein kinase 1 0.9116 0.9076 0.9076
Onchocerca volvulus 0.0252 0.003 0.0044
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Echinococcus granulosus fibroblast growth factor receptor 4 0.1454 0.1256 0.1256
Entamoeba histolytica protein kinase, putative 0.0625 0.0411 0.4184
Onchocerca volvulus 0.0651 0.0437 0.0654
Echinococcus multilocularis tyrosine protein kinase Srms 0.0927 0.0719 0.0719
Schistosoma mansoni serine/threonine-protein kinase 0.037 0.015 0.0405
Schistosoma mansoni vesicular amine transporter 0.0616 0.0402 0.1082
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Toxoplasma gondii CMGC kinase, CK2 family 0.0261 0.0039 0.0318
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0252 0.003 0.0303
Echinococcus granulosus tyrosine protein kinase Lyn 0.1289 0.1087 0.1087
Schistosoma mansoni serine/threonine protein kinase 0.0741 0.0528 0.1423
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0399 0.018 0.018
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0252 0.003 0.0212
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.5577 0.5464 0.5464
Schistosoma mansoni serine/threonine protein kinase 0.0326 0.0105 0.0283
Plasmodium falciparum casein kinase 1 0.0644 0.043 0.4333
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0252 0.003 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0381 0.0161 0.1489
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0398 0.0179 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0252 0.003 0.0212
Onchocerca volvulus 0.1184 0.0981 0.1468
Schistosoma mansoni serine/threonine protein kinase 0.0398 0.0179 0.0482
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0892 0.0683 0.0683
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0577 0.0361 0.363
Schistosoma mansoni septate junction protein 0.0274 0.0052 0.0141
Schistosoma mansoni tyrosine kinase 0.0887 0.0678 0.1825
Schistosoma mansoni serine/threonine RGC 0.0252 0.003 0.008
Echinococcus multilocularis serine:threonine protein kinase N2 0.1287 0.1086 0.1086
Entamoeba histolytica protein kinase, putative 0.04 0.018 0.1839
Onchocerca volvulus 0.0252 0.003 0.0044
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Echinococcus multilocularis casein kinase I alpha 0.0644 0.043 0.043
Brugia malayi Protein kinase domain containing protein 0.0242 0.0019 0.0019
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0252 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0519 0.0302 0.0814
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0519 0.0302 0.0302
Schistosoma mansoni protein kinase 0.0252 0.003 0.008
Echinococcus granulosus expressed protein 0.0242 0.0019 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0551 0.0335 0.0902
Echinococcus granulosus natriuretic peptide receptor 1 0.0252 0.003 0.003
Echinococcus multilocularis MAM 0.0342 0.0121 0.0121
Trichomonas vaginalis CMGC family protein kinase 0.0243 0.002 0.0118
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0723 0.051 0.051
Schistosoma mansoni serine/threonine protein kinase 0.0583 0.0368 0.0991
Brugia malayi hypothetical protein 0.0604 0.0389 0.0389
Echinococcus granulosus c src tyrosine kinase 0.0651 0.0437 0.0437
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0252 0.003 0.0044
Plasmodium falciparum tyrosine kinase-like protein 0.0252 0.003 0.0225
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis STE family protein kinase 0.0244 0.0021 0.0128
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0325 0.0104 0.0104
Echinococcus multilocularis casein kinase I delta 0.0644 0.043 0.043
Entamoeba histolytica serine/threonine kinase, putative 0.0252 0.003 0.0303
Loa Loa (eye worm) hypothetical protein 0.0252 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.1117 0.0912 0.0912
Brugia malayi hypothetical protein 0.0252 0.003 0.003
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1184 0.0981 0.0974
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0017 0.0047
Schistosoma mansoni protein kinase 0.0437 0.0219 0.0589
Entamoeba histolytica serine/threonine kinase, putative 0.0252 0.003 0.0303
Entamoeba histolytica serine/threonine kinase, putative 0.0252 0.003 0.0303
Echinococcus granulosus serine:threonine protein kinase 3 0.0438 0.0219 0.0219
Echinococcus multilocularis cGMP dependent protein kinase 1 0.03 0.0079 0.0079
Echinococcus multilocularis neuroglian 0.0309 0.0088 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Hr1 repeat family protein 0.1871 0.1681 0.1681
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Brugia malayi phosphoinositide-dependent protein kinase I 0.024 0.0017 0.0017
Giardia lamblia Kinase, STE STE20 0.04 0.018 0.1579
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Onchocerca volvulus Tyrosine kinase homolog 0.2925 0.2757 0.4126
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0583 0.0368 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.03 0.0079 0.0212
Trypanosoma cruzi protein kinase, putative 0.0252 0.003 0.0022
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0252 0.003 0.003
Onchocerca volvulus 0.0252 0.003 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0577 0.0361 0.0973
Schistosoma mansoni tyrosine kinase 0.1368 0.1169 0.3148
Echinococcus granulosus rho-associated protein kinase 1 0.0836 0.0626 0.0626
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0654 0.044 0.044
Loa Loa (eye worm) AGC/PKN protein kinase 0.1871 0.1681 0.1681
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) hypothetical protein 0.0984 0.0776 0.0776
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.076 0.0548 0.5545
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.2219 0.2037 0.2037
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0644 0.043 0.043
Echinococcus multilocularis casein kinase I gamma 0.0389 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0342 0.0121 0.0327
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0438 0.0219 0.0219
Brugia malayi Protein kinase domain containing protein 0.2296 0.2116 0.2116
Loa Loa (eye worm) hypothetical protein 0.0577 0.0361 0.0361
Loa Loa (eye worm) AUR protein kinase 0.0625 0.0411 0.0411
Schistosoma mansoni serine/threonine protein kinase 0.061 0.0395 0.1064
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0346 0.0126 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0625 0.0411 0.3903
Schistosoma mansoni protein kinase 0.2536 0.236 0.6359
Schistosoma mansoni serine/threonine protein kinase 0.1415 0.1217 0.3278
Echinococcus granulosus slit 2 protein 0.0271 0.0049 0.0049
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0252 0.003 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0551 0.0335 0.0902
Schistosoma mansoni septate junction protein 0.0274 0.0052 0.0141
Trichomonas vaginalis CK1 family protein kinase 0.0644 0.043 0.4087
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0252 0.003 0.003
Onchocerca volvulus 0.0426 0.0207 0.031
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1169 0.0965 0.0958
Echinococcus multilocularis dual specificity 0.0305 0.0084 0.0084
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0252 0.003 0.0212
Brugia malayi cyclin-dependent kinase 9 0.0385 0.0165 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.076 0.0548 0.1475
Echinococcus multilocularis cyclin dependent kinase 5 0.0519 0.0302 0.0302
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0268 0.0046 0.0046
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0399 0.018 0.0485
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.076 0.0548 0.0548
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.04 0.018 0.018
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 1.0022 1 1
Echinococcus multilocularis myosin iiia 0.0244 0.0021 0.0021
Brugia malayi Protein kinase domain containing protein 0.0475 0.0257 0.0257
Entamoeba histolytica hypothetical protein 0.0252 0.003 0.0303
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0252 0.003 0.003
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Trichomonas vaginalis STE family protein kinase 0.04 0.018 0.1672
Entamoeba histolytica hypothetical protein 0.0231 0.0008 0.0079
Entamoeba histolytica hypothetical protein 0.0252 0.003 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.061 0.0395 0.1064
Schistosoma mansoni serine/threonine protein kinase 0.0785 0.0574 0.1546
Echinococcus granulosus tyrosine protein kinase csk 0.0252 0.003 0.003
Echinococcus granulosus calcium activated potassium channel 0.0369 0.0149 0.0149
Schistosoma mansoni cell adhesion molecule 0.0738 0.0526 0.1416
Trichomonas vaginalis TKL family protein kinase 0.0255 0.0032 0.0238
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus granulosus MAM 0.0342 0.0121 0.0121
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) hypothetical protein 0.0268 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0519 0.0302 0.2852
Loa Loa (eye worm) hypothetical protein 0.0334 0.0113 0.0113
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.024 0.0017 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0252 0.003 0.003
Echinococcus multilocularis integrin linked protein kinase 0.0252 0.003 0.003
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0242 0.0019 0.0011
Entamoeba histolytica ankyrin repeat protein 0.0252 0.003 0.0303
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0475 0.0257 0.2622
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Echinococcus multilocularis tyrosine protein kinase otk 0.0274 0.0052 0.0052
Loa Loa (eye worm) TK/FER protein kinase 0.0818 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0468 0.025 0.025
Echinococcus multilocularis casein kinase I delta 0.0644 0.043 0.043
Echinococcus multilocularis TGF beta receptor type 1 0.0893 0.0684 0.0684
Trichomonas vaginalis AGC family protein kinase 0.0583 0.0368 0.3489
Schistosoma mansoni serine/threonine protein kinase 0.0375 0.0155 0.0417
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0818 0.0607 0.0607
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0243 0.002 0.0012
Trichomonas vaginalis STE family protein kinase 0.04 0.018 0.1672
Plasmodium falciparum calcium-dependent protein kinase 4 0.0577 0.0361 0.363
Echinococcus granulosus aurora kinase A 0.0625 0.0411 0.0411
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0252 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0651 0.0437 0.0437
Brugia malayi Fibronectin type III domain containing protein 0.0651 0.0437 0.0437
Giardia lamblia Kinase, NEK 0.0302 0.008 0.0599
Echinococcus granulosus receptor type guanylyl cyclase 0.0252 0.003 0.003
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0309 0.0088 0.0088
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.04 0.018 0.018
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1415 0.1217 0.1217
Echinococcus multilocularis cyclin dependent kinase 9 0.0385 0.0165 0.0165
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.076 0.0548 0.054
Entamoeba histolytica cysteine surface protein, putative 0.0252 0.003 0.0303
Plasmodium vivax tyrosine kinase-like protein, putative 0.0252 0.003 0.0225
Onchocerca volvulus 0.0252 0.003 0.0044
Schistosoma mansoni tyrosine kinase 0.0887 0.0678 0.1825
Echinococcus granulosus peroxidasin 0.0277 0.0056 0.0056
Leishmania major protein kinase, putative 0.1117 0.0912 0.0905
Trypanosoma cruzi aurora B kinase, putative 0.0625 0.0411 0.0403
Brugia malayi Protein kinase domain containing protein 0.0475 0.0257 0.0257
Brugia malayi Variant SH3 domain containing protein 0.0399 0.018 0.018
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1184 0.0981 0.2644
Schistosoma mansoni cell adhesion molecule 0.0309 0.0088 0.0236
Entamoeba histolytica protein kinase, putative 0.0228 0.0005 0.0052
Brugia malayi Variant SH3 domain containing protein 0.027 0.0048 0.0048
Trypanosoma cruzi protein kinase, putative 0.0252 0.003 0.0022
Echinococcus granulosus integrin linked protein kinase 0.0252 0.003 0.003
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.248 0.2304 0.2304
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0577 0.0361 0.0361
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.0052 0.0052
Echinococcus multilocularis hemicentin 1 0.0274 0.0052 0.0052
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0252 0.003 0.003
Echinococcus granulosus tyrosine protein kinase pr2 0.0252 0.003 0.003
Echinococcus granulosus protein tyrosine kinase 0.386 0.3712 0.3712
Entamoeba histolytica hypothetical protein 0.0231 0.0008 0.0079
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.0052 0.0052
Trypanosoma cruzi casein kinase, putative 0.0644 0.043 0.0422
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Toxoplasma gondii AGC kinase 0.076 0.0548 0.5545
Echinococcus granulosus tyrosine kinase 0.0927 0.0719 0.0719
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1184 0.0981 0.0981
Giardia lamblia Kinase, AGC PKA 0.076 0.0548 0.5177
Echinococcus granulosus mitogen activated protein kinase 14 1.0022 1 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0577 0.0361 0.363
Schistosoma mansoni serine/threonine kinase 0.0583 0.0368 0.0991
Brugia malayi integrin-linked kinase 0.0252 0.003 0.003
Trichomonas vaginalis STE family protein kinase 0.0375 0.0155 0.143
Giardia lamblia Kinase, CAMK CAMKL 0.0433 0.0215 0.1914
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Plasmodium falciparum protein kinase, putative 0.0437 0.0219 0.2166
Entamoeba histolytica receptor protein kinase, putative 0.0252 0.003 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.0686 0.0473 0.1274
Trichomonas vaginalis protein tyrosine kinase, putative 0.0252 0.003 0.0212
Echinococcus granulosus casein kinase I alpha 0.0644 0.043 0.043
Echinococcus granulosus activin receptor type 0.4053 0.3909 0.3909
Brugia malayi Tyrosine-protein kinase abl-1 0.1122 0.0918 0.0918
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1415 0.1217 0.1217
Echinococcus granulosus TGF beta receptor type 1 0.0893 0.0684 0.0684
Echinococcus multilocularis mitogen activated protein kinase 3 0.0243 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0475 0.0257 0.0257
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.3097 0.2933 0.2933
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Loa Loa (eye worm) RGC/RGC protein kinase 0.0252 0.003 0.003
Schistosoma mansoni tyrosine protein kinase 0.0252 0.003 0.008
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Trypanosoma cruzi polo-like protein kinase, putative 0.0346 0.0126 0.0118
Onchocerca volvulus 0.0459 0.0241 0.036
Loa Loa (eye worm) CAMK/PKD protein kinase 0.1106 0.0901 0.0901
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Brugia malayi Protein kinase domain containing protein 0.1707 0.1514 0.1514
Brugia malayi Protein kinase domain containing protein 0.0333 0.0113 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0519 0.0302 0.2852
Giardia lamblia Kinase, AGC PKA 0.0325 0.0104 0.083
Loa Loa (eye worm) hypothetical protein 0.0399 0.018 0.018
Entamoeba histolytica PH domain containing protein kinase, putative 0.0805 0.0594 0.6053
Entamoeba histolytica PH domain containing protein kinase, putative 0.0231 0.0008 0.0079
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1169 0.0965 0.0958
Trypanosoma brucei Flagellum attachment zone protein 20 0.0252 0.003 0.0022
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0252 0.003 0.008
Echinococcus multilocularis c src tyrosine kinase 0.0651 0.0437 0.0437
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.2296 0.2116 0.3166
Plasmodium falciparum protein serine/threonine kinase-1 0.1117 0.0912 0.9289
Brugia malayi hypothetical protein 0.0475 0.0257 0.0257
Brugia malayi Protein kinase domain containing protein 0.0789 0.0578 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.003 0.0212
Echinococcus granulosus Protein kinase C brain isozyme 0.0785 0.0574 0.0574
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0375 0.0155 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0461 0.0243 0.2281
Echinococcus granulosus activated cdc42 kinase 1 0.1707 0.1514 0.1514
Echinococcus multilocularis kinase suppressor of Ras 1 0.0252 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Echinococcus granulosus N chimaerin 0.0379 0.0159 0.0159
Entamoeba histolytica tyrosin kinase, putative 0.03 0.0079 0.0803
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Echinococcus granulosus serine:threonine protein kinase N2 0.1287 0.1086 0.1086
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0366 0.0146 0.0146
Echinococcus multilocularis dual specificity protein kinase clk2 0.1117 0.0912 0.0912
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0437 0.0219 0.0219
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0346 0.0126 0.0126
Brugia malayi Temporarily assigned gene name protein 59 0.0707 0.0494 0.0494
Echinococcus multilocularis insulin receptor 0.1368 0.1169 0.1169
Schistosoma mansoni serine/threonine protein kinase 0.0326 0.0105 0.0283
Brugia malayi C1-like domain containing protein 0.1106 0.0901 0.0901
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Onchocerca volvulus 0.0342 0.0121 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.0126 0.1143
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0309 0.0088 0.0088
Schistosoma mansoni tyrosine kinase 0.0716 0.0503 0.1356
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0274 0.0052 0.0078
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.3206 0.3044 0.3044
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0252 0.003 0.0225
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0244 0.0021 0.0013
Leishmania major protein kinase, putative 0.0437 0.0219 0.0211
Loa Loa (eye worm) hypothetical protein 0.0651 0.0437 0.0437
Echinococcus granulosus kinase suppressor of Ras 1 0.0252 0.003 0.003
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Echinococcus granulosus cGMP dependent protein kinase 0.03 0.0079 0.0079
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0243 0.002 0.0125
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.2296 0.2116 0.2116
Echinococcus multilocularis serine:threonine protein kinase 0.0368 0.0148 0.0148
Echinococcus multilocularis beta adrenergic receptor kinase 0.0326 0.0105 0.0105
Brugia malayi Protein kinase domain containing protein 0.0825 0.0615 0.0615
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.1117 0.0912 0.0905
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1103 0.0898 0.0898
Brugia malayi Protein kinase domain containing protein 0.1368 0.1169 0.1169
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0278 0.0056 0.0056
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0437 0.0219 0.0211
Loa Loa (eye worm) hypothetical protein 0.0274 0.0052 0.0052
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Loa Loa (eye worm) hypothetical protein 0.076 0.0548 0.0548
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0239 0.0017 0.0092
Loa Loa (eye worm) hypothetical protein 0.0274 0.0052 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0625 0.0411 0.3903
Loa Loa (eye worm) hypothetical protein 0.0757 0.0545 0.0545
Leishmania major protein kinase A catalytic subunit isoform 2 0.076 0.0548 0.054
Trichomonas vaginalis CMGC family protein kinase 0.0305 0.0084 0.0734
Trichomonas vaginalis CMGC family protein kinase 0.1184 0.0981 0.9432
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0519 0.0302 0.0295
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0707 0.0494 0.0494
Echinococcus multilocularis mitogen activated protein kinase 14 1.0022 1 1
Brugia malayi SH2 domain containing protein 0.0475 0.0257 0.0257
Echinococcus granulosus tyrosine protein kinase csk 0.0252 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1103 0.0898 0.0898
Echinococcus multilocularis epidermal growth factor receptor 0.1044 0.0837 0.0837
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.076 0.0548 0.5545
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Entamoeba histolytica protein kinase domain containing protein 0.0385 0.0165 0.168
Trichomonas vaginalis AGC family protein kinase 0.0769 0.0557 0.5319
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.0126 0.1143
Trypanosoma cruzi casein kinase, putative 0.0644 0.043 0.0422
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0577 0.0361 0.0361
Giardia lamblia Kinase, CMGC CDK 0.0519 0.0302 0.2772
Echinococcus granulosus tyrosine protein kinase HCK 0.0704 0.0491 0.0491
Entamoeba histolytica protein kinase, putative 0.0578 0.0363 0.3695
Brugia malayi Stress-activated protein kinase jnk-1 0.3206 0.3044 0.3044
Echinococcus multilocularis cyclin dependent kinase 1 0.0519 0.0302 0.0302
Echinococcus granulosus serine:threonine protein kinase N2 0.1871 0.1681 0.1681
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0836 0.0626 0.1686
Schistosoma mansoni serine/threonine protein kinase 0.076 0.0548 0.1475
Trypanosoma cruzi cdc2-related kinase 3 0.0519 0.0302 0.0295
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0252 0.003 0.008
Schistosoma mansoni tyrosine kinase 0.2247 0.2065 0.5564
Giardia lamblia Aurora kinase 0.0625 0.0411 0.3834
Entamoeba histolytica protein kinase, putative 0.0231 0.0008 0.0079
Echinococcus granulosus cyclin dependent kinase 9 0.0419 0.0201 0.0201
Trypanosoma brucei Pseudokinase, putative 0.0252 0.003 0.0022
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0244 0.0021 0.0214
Echinococcus multilocularis FL cytokine receptor 0.0252 0.003 0.003
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0252 0.003 0.008
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0757 0.0545 0.0545
Entamoeba histolytica hypothetical protein 0.1169 0.0965 0.9839
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0275 0.0053 0.0053
Entamoeba histolytica PH domain containing protein kinase, putative 0.037 0.015 0.1532
Schistosoma mansoni tyrosine kinase 0.1044 0.0837 0.2256
Echinococcus granulosus protein kinase c iota type 0.0833 0.0622 0.0622
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0616 0.0402 0.1082
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.076 0.0548 0.0548
Entamoeba histolytica hypothetical protein, conserved 0.0252 0.003 0.0303
Echinococcus multilocularis slit 2 protein 0.0271 0.0049 0.0049
Loa Loa (eye worm) TK/EPH protein kinase 0.0344 0.0124 0.0124
Echinococcus multilocularis 0.0931 0.0723 0.0723
Giardia lamblia Kinase, CK1 Casein kinase 0.0644 0.043 0.4021
Brugia malayi Doublecortin family protein 0.0318 0.0097 0.0097
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0583 0.0368 0.0368
Loa Loa (eye worm) RGC/RGC protein kinase 0.0252 0.003 0.003
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0252 0.003 0.0022
Echinococcus multilocularis ephrin type A receptor 4 A 0.0324 0.0103 0.0103
Echinococcus multilocularis 0.0238 0.0015 0.0015
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.1169 0.0965 0.0958
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) hypothetical protein 0.0616 0.0402 0.0402
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.04 0.018 0.018
Schistosoma mansoni serine/threonine protein kinase 0.3097 0.2933 0.7902
Echinococcus granulosus protein kinase C gamma type 0.063 0.0415 0.0415
Onchocerca volvulus Serine\/threonine kinase homolog 0.0346 0.0126 0.0188
Brugia malayi Variant SH3 domain containing protein 0.0379 0.0159 0.0159
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Echinococcus granulosus epidermal growth factor receptor 0.1044 0.0837 0.0837
Schistosoma mansoni protein tyrosine kinase 0.0252 0.003 0.008
Entamoeba histolytica tyrosin kinase, putative 0.0252 0.003 0.0303
Schistosoma mansoni nephrin 0.0838 0.0628 0.1692
Loa Loa (eye worm) hypothetical protein 0.0252 0.003 0.003
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1415 0.1217 0.1217
Brugia malayi serine/threonine kinase 12 0.0625 0.0411 0.0411
Echinococcus multilocularis roundabout 2 0.0309 0.0088 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Entamoeba histolytica protein kinase domain containing protein 0.1184 0.0981 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0583 0.0368 0.0368
Brugia malayi protein-tyrosine kinase 0.0927 0.0719 0.0719
Schistosoma mansoni serine/threonine protein kinase 0.0407 0.0188 0.0506
Trichomonas vaginalis STE family protein kinase 0.1242 0.104 1
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis CMGC family protein kinase 0.0243 0.002 0.0118
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0244 0.0021 0.0013
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0979 0.0772 0.0772
Schistosoma mansoni vam6/vps39 related 0.0707 0.0494 0.133
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0244 0.0021 0.0013
Trypanosoma brucei polo-like protein kinase 0.0346 0.0126 0.0118
Echinococcus multilocularis serine:threonine protein kinase 3 0.0438 0.0219 0.0219
Brugia malayi hypothetical protein 0.0342 0.0121 0.0121
Giardia lamblia Kinase, NEK 0.0252 0.003 0.0103
Brugia malayi Protein kinase domain containing protein 0.0475 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0555 0.0339 0.0339
Trichomonas vaginalis AGC family protein kinase 0.0769 0.0557 0.5319
Trypanosoma brucei mitogen-activated protein kinase 3, putative 1.0022 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1103 0.0898 0.0898
Schistosoma mansoni serine/threonine protein kinase 0.0333 0.0113 0.0303
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0311 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0252 0.003 0.003
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1103 0.0898 0.0898
Leishmania major protein kinase, putative 0.0244 0.0021 0.0013
Schistosoma mansoni neuroglian 0.0309 0.0088 0.0236
Echinococcus granulosus contactin 0.0309 0.0088 0.0088
Brugia malayi Protein kinase domain containing protein 0.0389 0.0169 0.0169
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Tyrosine-protein kinase PR2 0.0252 0.003 0.003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3441 0.3284 0.3284
Loa Loa (eye worm) AUR protein kinase 0.0625 0.0411 0.0411
Trypanosoma brucei protein kinase, putative 0.0437 0.0219 0.0211
Loa Loa (eye worm) hypothetical protein 0.0521 0.0304 0.0304
Brugia malayi Protein kinase domain containing protein 0.0475 0.0257 0.0257
Schistosoma mansoni protein kinase 0.0252 0.003 0.008
Toxoplasma gondii protein kinase domain-containing protein 0.0252 0.003 0.0225
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trypanosoma brucei protein kinase, putative 0.1184 0.0981 0.0974
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.2029 0.1843 0.1843
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1593 0.1399 0.1399
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.2536 0.236 0.236
Schistosoma mansoni tyrosine kinase 0.0442 0.0224 0.0603
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2292 0.2112 0.2112
Plasmodium falciparum protein kinase, putative 0.0252 0.003 0.0225
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0274 0.0052 0.0052
Giardia lamblia Kinase, CAMK CAMKL 0.0433 0.0215 0.1914
Echinococcus granulosus tyrosine protein kinase Blk 0.0927 0.0719 0.0719
Schistosoma mansoni serine/threonine protein kinase 0.0369 0.0149 0.04
Brugia malayi Protein kinase domain containing protein 0.2211 0.2029 0.2029
Loa Loa (eye worm) hypothetical protein 0.0825 0.0615 0.0615
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.076 0.0548 0.054
Trichomonas vaginalis CMGC family protein kinase 0.0305 0.0084 0.0734
Echinococcus granulosus TGF-beta receptor type-1 0.0893 0.0684 0.0684
Echinococcus granulosus roundabout 2 0.0925 0.0717 0.0717
Trichomonas vaginalis AGC family protein kinase 0.0583 0.0368 0.3489
Toxoplasma gondii AGC kinase 0.076 0.0548 0.5545
Echinococcus multilocularis growth factor receptor bound protein 2 0.0399 0.018 0.018
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0577 0.0361 0.363
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Brugia malayi hypothetical protein 0.0707 0.0494 0.0494
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Echinococcus granulosus beta-adrenergic receptor kinase 0.0326 0.0105 0.0105
Echinococcus granulosus cGMP dependent protein kinase 1 0.03 0.0079 0.0079
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0377 0.0157 0.0157
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1454 0.1256 0.1256
Echinococcus multilocularis c Jun NH2 terminal kinase 0.3206 0.3044 0.3044
Loa Loa (eye worm) IKK protein kinase 0.6772 0.6684 0.6684
Echinococcus multilocularis serine threonine protein kinase 0.063 0.0415 0.0415
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0437 0.0219 0.2166
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.1242 0.104 0.1033
Loa Loa (eye worm) hypothetical protein 0.1353 0.1154 0.1154
Loa Loa (eye worm) SRC-1 0.1103 0.0898 0.0898
Echinococcus multilocularis tyrosine protein kinase HCK 0.0704 0.0491 0.0491
Schistosoma mansoni protein kinase 0.0437 0.0219 0.0589
Giardia lamblia Kinase, NEK 0.0302 0.008 0.0599
Echinococcus multilocularis tyrosine protein kinase Blk 0.0927 0.0719 0.0719
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1103 0.0898 0.0898
Trichomonas vaginalis CMGC family protein kinase 0.0305 0.0084 0.0734
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0252 0.003 0.003
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1184 0.0981 0.0981
Schistosoma mansoni protein kinase 0.1686 0.1493 0.4021
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Trypanosoma cruzi cdc2-related kinase 1 0.0519 0.0302 0.0295
Onchocerca volvulus 0.0252 0.003 0.0044
Entamoeba histolytica protein kinase, putative 0.0242 0.0019 0.0196
Brugia malayi map kinase activated protein kinase protein 2 0.0593 0.0378 0.0378
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0252 0.003 0.003
Entamoeba histolytica tyrosin kinase, putative 0.0252 0.003 0.0303
Entamoeba histolytica serine/threonine protein kinase, putative 0.0346 0.0126 0.1282
Echinococcus granulosus calcium dependent protein kinase 0.0392 0.0172 0.0172
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.003 0.008
Entamoeba histolytica protein kinase, putative 0.1184 0.0981 1
Loa Loa (eye worm) hypothetical protein 0.0342 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0274 0.0052 0.0052
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0644 0.043 0.0422
Loa Loa (eye worm) AUR protein kinase 0.0625 0.0411 0.0411
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0616 0.0402 0.1082
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0228 0.0005 0.0005
Schistosoma mansoni ephrin receptor 0.0324 0.0103 0.0279
Entamoeba histolytica hypothetical protein 0.0429 0.021 0.2144
Brugia malayi Protein kinase domain containing protein 0.0807 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0926 0.0717 0.0717
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0927 0.0719 0.0719
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi EGF-like domain containing protein 0.0271 0.0049 0.0049
Plasmodium falciparum NIMA related kinase 1 0.0302 0.008 0.0745
Brugia malayi Raf kinase 0.0252 0.003 0.003
Echinococcus granulosus casein kinase I alpha 0.0644 0.043 0.043
Loa Loa (eye worm) AGC/PKA protein kinase 0.076 0.0548 0.0548
Onchocerca volvulus 0.0475 0.0257 0.0385
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0005 0.0014
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.024 0.0017 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Echinococcus granulosus growth factor receptor bound protein 2 0.0415 0.0196 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0305 0.0084 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.0126 0.1143
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0368 0.0148 0.0148
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus granulosus tyrosine kinase 0.0475 0.0257 0.0257
Brugia malayi Immunoglobulin I-set domain containing protein 0.0309 0.0088 0.0088
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0377 0.0157 0.0157
Echinococcus multilocularis casein kinase I alpha 0.0644 0.043 0.043
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Entamoeba histolytica ankyrin repeat protein 0.0252 0.003 0.0303
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Echinococcus multilocularis cyclin dependent kinase 9 0.0419 0.0201 0.0201
Trichomonas vaginalis CK1 family protein kinase 0.0644 0.043 0.4087
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.1242 0.104 0.1033
Trichomonas vaginalis STE family protein kinase 0.1242 0.104 1
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Schistosoma mansoni protein kinase 0.04 0.018 0.0486
Echinococcus multilocularis natriuretic peptide receptor 1 0.0252 0.003 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0039 0.03
Brugia malayi Protein kinase domain containing protein 0.0583 0.0368 0.0368
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.03 0.0079 0.0727
Echinococcus granulosus serine:threonine protein kinase 0.0368 0.0148 0.0148
Loa Loa (eye worm) RGC/RGC protein kinase 0.0252 0.003 0.003
Echinococcus multilocularis protein kinase shaggy 0.1184 0.0981 0.0981
Entamoeba histolytica serine/threonine kinase, putative 0.0252 0.003 0.0303
Echinococcus granulosus protein kinase shaggy 0.1184 0.0981 0.0981
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0927 0.0719 0.0719
Schistosoma mansoni serine/threonine protein kinase 0.1117 0.0912 0.2457
Loa Loa (eye worm) hypothetical protein 0.0651 0.0437 0.0437
Entamoeba histolytica protein kinase domain containing protein 0.0305 0.0084 0.0852
Loa Loa (eye worm) hypothetical protein 0.0757 0.0545 0.0545
Onchocerca volvulus 0.0707 0.0494 0.0738
Schistosoma mansoni protein kinase 0.0625 0.0411 0.1106
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Schistosoma mansoni ste20-related kinase 0.038 0.016 0.0431
Echinococcus multilocularis calcium activated potassium channel 0.0369 0.0149 0.0149
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.076 0.0548 0.0548
Loa Loa (eye worm) AGC/AKT protein kinase 0.0769 0.0557 0.0557
Entamoeba histolytica protein kinase, putative 0.0704 0.0491 0.5004
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus multilocularis roundabout 2 0.0309 0.0088 0.0088
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1453 0.1255 0.1255
Plasmodium falciparum calcium-dependent protein kinase 2 0.0577 0.0361 0.363
Schistosoma mansoni protein kinase 0.2536 0.236 0.6359
Brugia malayi Tyrosine-protein kinase abl-1 0.1346 0.1146 0.1146
Echinococcus multilocularis 0.0979 0.0772 0.0772
Echinococcus granulosus activated cdc42 kinase 1 0.1707 0.1514 0.1514
Trypanosoma cruzi casein kinase, putative 0.0644 0.043 0.0422
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.003 0.008
Brugia malayi RhoGAP domain containing protein 0.0379 0.0159 0.0159
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Leishmania major protein kinase A catalytic subunit isoform 1 0.076 0.0548 0.054
Brugia malayi putative serine/threonine kinase SADA gamma 0.0398 0.0179 0.0179
Echinococcus granulosus casein kinase I gamma 0.0389 0.0169 0.0169
Entamoeba histolytica protein kinase, putative 0.0375 0.0155 0.1584
Brugia malayi Immunoglobulin I-set domain containing protein 0.0651 0.0437 0.0437
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0407 0.0188 0.0188
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 1.0022 1 1
Brugia malayi Protein kinase domain containing protein 0.0375 0.0155 0.0155
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0379 0.0159 0.0159
Entamoeba histolytica protein kinase, putative 0.0228 0.0005 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0385 0.0165 0.0444
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.1454 0.1257 0.1257
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0707 0.0494 0.0486
Echinococcus granulosus tyrosine protein kinase 0.0252 0.003 0.003
Brugia malayi SH2 domain containing protein 0.0818 0.0607 0.0607
Schistosoma mansoni roundabout 0.0274 0.0052 0.0141
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0252 0.003 0.003
Entamoeba histolytica serine/threonine kinase, putative 0.0252 0.003 0.0303
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Echinococcus multilocularis tyrosine kinase 0.0475 0.0257 0.0257
Plasmodium vivax casein kinase 1, putative 0.0644 0.043 0.4333
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0519 0.0302 0.0302
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.0052 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.0126 0.1143
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0242 0.0019 0.0011
Schistosoma mansoni kinase 0.0385 0.0165 0.0444
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0252 0.003 0.003
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.1117 0.0912 0.0905
Plasmodium falciparum glycogen synthase kinase 3 0.1184 0.0981 1
Brugia malayi Casein kinase II, alpha chain 0.0261 0.0039 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.1102 0.0897 0.2417
Echinococcus granulosus cyclin dependent kinase 5 0.0519 0.0302 0.0302
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0039 0.03
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0625 0.0411 0.4184
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0461 0.0243 0.0243
Brugia malayi serine/threonine-protein kinase 6 0.0625 0.0411 0.0411
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1184 0.0981 0.0981
Brugia malayi Egg laying defective protein 4 0.03 0.0079 0.0079
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0228 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.056 0.0344 0.0344
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0408 0.0189 0.1926
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0551 0.0335 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.0398 0.0179 0.0482
Trypanosoma brucei aurora B kinase 0.0625 0.0411 0.0403
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.1117 0.0912 0.0905
Toxoplasma gondii histone kinase SNF1, putative 0.0398 0.0179 0.1758
Onchocerca volvulus 0.2486 0.2309 0.3455
Entamoeba histolytica protein kinase , putative 0.0625 0.0411 0.4184
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0593 0.0378 0.0378
Brugia malayi Protein kinase domain containing protein 0.0769 0.0557 0.0557
Brugia malayi probable protein kinase 0.1686 0.1493 0.1493
Loa Loa (eye worm) TK protein kinase 0.0252 0.003 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Schistosoma mansoni tyrosine kinase 0.1368 0.1169 0.3148
Entamoeba histolytica protein kinase domain containing protein 0.1184 0.0981 1
Schistosoma mansoni serine/threonine protein kinase 0.1593 0.1399 0.3768
Loa Loa (eye worm) AGC/PKA protein kinase 0.076 0.0548 0.0548
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0577 0.0361 0.363
Schistosoma mansoni protein kinase 0.0252 0.003 0.008
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0399 0.018 0.018
Echinococcus multilocularis protein kinase 0.0252 0.003 0.003
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.076 0.0548 0.054
Brugia malayi casein kinase 1, delta 0.0644 0.043 0.043
Schistosoma mansoni tyrosine kinase 0.0635 0.042 0.1132
Schistosoma mansoni tyrosine kinase 0.0651 0.0437 0.1178
Brugia malayi serine/threonine-protein kinase plk-2 0.0346 0.0126 0.0126
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0398 0.0179 0.0171
Loa Loa (eye worm) TK/Met protein kinase 0.0252 0.003 0.003
Brugia malayi STE20-like kinase MST 0.0438 0.0219 0.0219
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0346 0.0126 0.0118
Trichomonas vaginalis AGC family protein kinase 0.0629 0.0414 0.3939
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0625 0.0411 0.4184
Entamoeba histolytica PH domain containing protein kinase, putative 0.0805 0.0594 0.6053
Brugia malayi Protein kinase domain containing protein 0.024 0.0017 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0577 0.0361 0.3424
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0574 0.0359 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0769 0.0557 0.5319
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0593 0.0378 0.0378
Schistosoma mansoni tyrosine kinase 0.0635 0.042 0.1132
Brugia malayi Immunoglobulin I-set domain containing protein 0.0309 0.0088 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0398 0.0179 0.0171
Entamoeba histolytica p21-activated kinase 0.0445 0.0227 0.2311
Giardia lamblia Kinase, PLK 0.0346 0.0126 0.1044
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.076 0.0548 0.054
Schistosoma mansoni serine/threonine-protein kinase 0.037 0.015 0.0405
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.1062 0.0857 0.085
Entamoeba histolytica protein kinase domain containing protein 0.1169 0.0965 0.9839
Entamoeba histolytica protein kinase, putative 0.0583 0.0368 0.375
Loa Loa (eye worm) TK/ALK protein kinase 0.493 0.4804 0.4804
Entamoeba histolytica hypothetical protein 0.0252 0.003 0.0303
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.1117 0.0912 0.9289
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.051 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0566 0.035 0.035
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi ephrin receptor 1 precursor 0.0286 0.0064 0.0064
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0551 0.0335 0.0335
Plasmodium falciparum calcium-dependent protein kinase 5 0.0577 0.0361 0.363
Loa Loa (eye worm) TK/FER protein kinase 0.0252 0.003 0.003
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0228 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0039 0.03
Entamoeba histolytica serine/threonine kinase, putative 0.0252 0.003 0.0303
Schistosoma mansoni titin 0.0274 0.0052 0.0141
Loa Loa (eye worm) hypothetical protein 0.0891 0.0682 0.0682
Schistosoma mansoni protein kinase 0.1242 0.104 0.2802
Brugia malayi Protein kinase domain containing protein 0.0583 0.0368 0.0368
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) CAMK/PIM protein kinase 0.2296 0.2116 0.2116
Plasmodium falciparum calcium-dependent protein kinase 3 0.0577 0.0361 0.363
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Protein kinase domain containing protein 0.3903 0.3756 0.3756
Loa Loa (eye worm) hypothetical protein 0.0616 0.0402 0.0402
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0243 0.002 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) hypothetical protein 0.0966 0.0758 0.0758
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.1102 0.0897 0.0897
Leishmania major hypothetical protein, conserved 0.0252 0.003 0.0022
Giardia lamblia Kinase, NEK 0.0302 0.008 0.0599
Trypanosoma brucei cdc2-related kinase 1 0.0519 0.0302 0.0295
Entamoeba histolytica protein kinase, putative 0.1169 0.0965 0.9839
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0519 0.0302 0.0302
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0398 0.0179 0.0171
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0309 0.0088 0.0088
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.076 0.0548 0.054
Brugia malayi Cam kinase protein 1 0.0577 0.0361 0.0361
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0577 0.0361 0.363
Schistosoma mansoni serine/threonine protein kinase 0.0644 0.043 0.1157
Toxoplasma gondii casein kinase I 0.0644 0.043 0.4333
Echinococcus granulosus hemicentin 1 0.0274 0.0052 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0275 0.0053 0.0438
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1454 0.1256 0.1256
Brugia malayi Immunoglobulin I-set domain containing protein 0.0309 0.0088 0.0088
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0242 0.0019 0.0019
Loa Loa (eye worm) AGC/PKG protein kinase 0.03 0.0079 0.0079
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.1117 0.0912 0.0905
Brugia malayi hypothetical protein 0.0651 0.0437 0.0437
Brugia malayi SRC-1 0.1103 0.0898 0.0898
Loa Loa (eye worm) hypothetical protein 0.0309 0.0088 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0818 0.0607 0.0607
Plasmodium falciparum calcium-dependent protein kinase 1 0.0577 0.0361 0.363
Brugia malayi Protein kinase domain containing protein 0.0475 0.0257 0.0257
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.1169 0.0965 0.0958
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.0056 0.0468
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Entamoeba histolytica tyrosin kinase, putative 0.0252 0.003 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.1774 0.1583 0.4264
Giardia lamblia Kinase, AGC AKT 0.1017 0.081 0.7751
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0825 0.0615 0.0615
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.051 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.077 0.0558 0.0558
Toxoplasma gondii protein kinase 0.0252 0.003 0.0225
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2211 0.2029 0.2029
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0252 0.003 0.003
Schistosoma mansoni nck2/grb4 0.0399 0.018 0.0485
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi cell division control protein 2 homolog 0.0519 0.0302 0.0302
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0625 0.0411 0.0411
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0242 0.0019 0.0011
Trichomonas vaginalis protein kinase atn1, putative 0.0252 0.003 0.0212
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.1242 0.104 0.104
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0439 0.0221 0.0221
Entamoeba histolytica receptor protein kinase, putative 0.0252 0.003 0.0303
Brugia malayi Variant SH3 domain containing protein 0.0399 0.018 0.018
Brugia malayi C-terminal src kinase protein 1 0.0252 0.003 0.003
Echinococcus multilocularis Immunoglobulin 0.0616 0.0402 0.0402
Schistosoma mansoni serine/threonine protein kinase 0.1771 0.158 0.4257
Brugia malayi Protein kinase domain containing protein 0.0475 0.0257 0.0257
Echinococcus granulosus casein kinase ii subunit alpha 0.0261 0.0039 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0252 0.003 0.003
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0706 0.0493 0.0493
Echinococcus granulosus defective proboscis extension response 0.0616 0.0402 0.0402
Echinococcus multilocularis mitogen activated protein kinase 14 1.0022 1 1
Brugia malayi cyclin-dependent kinase 7 homolog 0.0645 0.0431 0.0431
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Plasmodium falciparum cGMP-dependent protein kinase 0.03 0.0079 0.0727
Schistosoma mansoni atypical protein kinase C 0.084 0.0629 0.1696
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Serine/threonine-protein kinase SULU 0.3097 0.2933 0.2933
Schistosoma mansoni tyrosine kinase 0.1103 0.0898 0.2421
Schistosoma mansoni protein kinase 0.248 0.2304 0.6206
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.1169 0.0965 0.2601
Brugia malayi Immunoglobulin I-set domain containing protein 0.1641 0.1447 0.1447
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.2296 0.2116 0.2116
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0039 0.03
Echinococcus granulosus cyclin dependent kinase 19 0.1771 0.158 0.158
Giardia lamblia Kinase, CMGC GSK 0.1184 0.0981 0.9425
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Onchocerca volvulus 0.0361 0.0141 0.0211
Entamoeba histolytica protein kinase 2, putative 0.0325 0.0104 0.1059
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Echinococcus granulosus tyrosine protein kinase Fyn 0.1103 0.0898 0.0898
Giardia lamblia Kinase, NEK 0.0252 0.003 0.0103
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Schistosoma mansoni hypothetical protein 0.0342 0.0121 0.0327
Echinococcus granulosus tyrosine protein kinase ABL1 0.2292 0.2112 0.2112
Schistosoma mansoni serine/threonine protein kinase 0.0618 0.0404 0.1087
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0239 0.0017 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0625 0.0411 0.3903
Trichomonas vaginalis CMGC family protein kinase 0.0243 0.002 0.0118
Trypanosoma brucei Casein kinase II 0.0261 0.0039 0.0031
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi p70 ribosomal S6 kinase beta 0.0723 0.051 0.051
Brugia malayi serine/threonine protein kinase 6 0.0625 0.0411 0.0411
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0255 0.0033 0.0334
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) hypothetical protein 0.0704 0.049 0.049
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1184 0.0981 0.0974
Schistosoma mansoni serine/threonine protein kinase 0.1145 0.0941 0.2535
Loa Loa (eye worm) hypothetical protein 0.0252 0.003 0.003
Plasmodium vivax protein kinase, putative 0.0269 0.0047 0.0403
Loa Loa (eye worm) hypothetical protein 0.0252 0.003 0.003
Onchocerca volvulus 0.0475 0.0257 0.0385
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.0126 0.0339
Brugia malayi Protein kinase c protein 2 0.0387 0.0167 0.0167
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0377 0.0157 0.0157
Echinococcus granulosus serine/threonine protein kinase 0.037 0.015 0.015
Echinococcus multilocularis tyrosine protein kinase shark 0.0716 0.0503 0.0503
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Protein kinase domain containing protein 0.0368 0.0148 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.1871 0.1681 0.453
Loa Loa (eye worm) hypothetical protein 0.0566 0.035 0.035
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1771 0.158 0.158
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Echinococcus granulosus adam 17 protease 0.0245 0.0023 0.0023
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0346 0.0126 0.0126
Loa Loa (eye worm) protein kinase domain-containing protein 0.0389 0.0169 0.0169
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.2296 0.2116 0.57
Brugia malayi Protein kinase domain containing protein 0.1771 0.158 0.158
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.1106 0.0901 0.0901
Onchocerca volvulus 0.0252 0.003 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.003 0.0212
Echinococcus granulosus neuroglian 0.0804 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0342 0.0121 0.0121
Echinococcus granulosus tyrosine protein kinase Src42A 0.0691 0.0478 0.0478
Trypanosoma cruzi cdc2-related kinase 3 0.0519 0.0302 0.0295
Echinococcus granulosus lachesin 0.0274 0.0052 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0311 0.009 0.009
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0252 0.003 0.003
Brugia malayi protein unc-22 0.0407 0.0188 0.0188
Echinococcus granulosus dual specificity 0.0305 0.0084 0.0084
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0278 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0274 0.0052 0.0052
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Plasmodium falciparum casein kinase 2, alpha subunit 0.0261 0.0039 0.0318
Loa Loa (eye worm) thyroid receptor interactor 0.0893 0.0684 0.0684
Schistosoma mansoni tyrosine kinase 0.1103 0.0898 0.2421
Echinococcus multilocularis activated cdc42 kinase 1 0.1707 0.1514 0.1514
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0302 0.008 0.0745
Schistosoma mansoni protein kinase 0.0261 0.0039 0.0105
Trichomonas vaginalis CMGC family protein kinase 0.1117 0.0912 0.8761
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2407 0.2229 0.2229
Schistosoma mansoni tyrosine kinase 0.0526 0.031 0.0834
Loa Loa (eye worm) TK protein kinase 0.0252 0.003 0.003
Onchocerca volvulus 0.0966 0.0758 0.1135
Entamoeba histolytica hypothetical protein 0.0252 0.003 0.0303
Loa Loa (eye worm) TK/CSK protein kinase 0.0252 0.003 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.0475 0.0257 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.0056 0.0468
Leishmania major casein kinase II, putative 0.0261 0.0039 0.0031
Echinococcus multilocularis cyclin dependent kinase 7 0.061 0.0395 0.0395
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0309 0.0088 0.0088
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0812 0.0601 0.0601
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.1145 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0368 0.0148 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.3206 0.3044 0.82
Trichomonas vaginalis CMGC family protein kinase 0.0305 0.0084 0.0734
Plasmodium vivax unspecified product 0.0261 0.0039 0.0318
Trichomonas vaginalis CK1 family protein kinase 0.0644 0.043 0.4087
Echinococcus multilocularis peroxidasin 0.0277 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1103 0.0898 0.0898
Plasmodium falciparum serine/threonine protein kinase KIN 0.0398 0.0179 0.1758
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.076 0.0548 0.0548
Brugia malayi Guanylyl cyclase protein 23 0.0252 0.003 0.003
Echinococcus multilocularis dual specificity 0.0305 0.0084 0.0084
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0379 0.0159 0.0159
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Furin-like cysteine rich region family protein 0.1044 0.0837 0.0837
Echinococcus granulosus serine:threonine protein kinase mig 15 0.15 0.1304 0.1304
Onchocerca volvulus Serine\/threonine kinase homolog 0.0333 0.0113 0.0168
Echinococcus granulosus protein kinase 0.0252 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0305 0.0084 0.0225
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0274 0.0052 0.0052
Echinococcus granulosus tyrosine protein kinase otk 0.0274 0.0052 0.0052
Echinococcus multilocularis epidermal growth factor receptor 0.0887 0.0678 0.0678
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.1145 0.0941 0.0941
Entamoeba histolytica protein kinase, putative 0.0408 0.0189 0.1926
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Echinococcus granulosus retinal guanylyl cyclase 2 0.0252 0.003 0.003
Schistosoma mansoni rap gtpase-activating protein 0.0707 0.0494 0.133
Giardia lamblia Kinase, CMGC CLK 0.1117 0.0912 0.8747
Schistosoma mansoni hypothetical protein 0.0252 0.003 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.0252 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Echinococcus granulosus dual specificity 0.0305 0.0084 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0625 0.0411 0.1106
Schistosoma mansoni ephrin receptor 0.0287 0.0065 0.0175
Trichomonas vaginalis AGC family protein kinase 0.0769 0.0557 0.5319
Giardia lamblia Kinase 0.0252 0.003 0.0103
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0305 0.0084 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0769 0.0557 0.5319
Echinococcus multilocularis Immunoglobulin 0.0616 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.15 0.1304 0.1304
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0242 0.0019 0.0117
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0707 0.0494 0.0494
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0616 0.0402 0.0402
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.096 0.0752 0.0752
Trichomonas vaginalis CMGC family protein kinase 0.0305 0.0084 0.0734
Trichomonas vaginalis CMGC family protein kinase 0.0243 0.002 0.0118
Schistosoma mansoni nephrin 0.0309 0.0088 0.0236
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0243 0.002 0.002
Plasmodium vivax serine/threonine kinase-1, putative 0.1117 0.0912 0.9289
Echinococcus multilocularis hemicentin 1 0.0274 0.0052 0.0052
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.061 0.0395 0.0395
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Brugia malayi Prion-like- 0.0274 0.0052 0.0052
Echinococcus multilocularis tyrosine protein kinase csk 0.0252 0.003 0.003
Entamoeba histolytica protein kinase domain containing protein 0.0377 0.0157 0.1599
Plasmodium falciparum serine/threonine protein kinase, putative 0.0625 0.0411 0.4138
Schistosoma mansoni protein kinase 0.2536 0.236 0.6359
Giardia lamblia Kinase, STE STE20 0.1242 0.104 1
Loa Loa (eye worm) hypothetical protein 0.077 0.0558 0.0558
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1454 0.1256 0.1256
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0741 0.0528 0.0528
Echinococcus granulosus dual specificity protein kinase clk2 0.1117 0.0912 0.0912
Loa Loa (eye worm) TK protein kinase 0.0704 0.0491 0.0491
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.2029 0.1843 0.1843
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0691 0.0478 0.0478
Schistosoma mansoni serine/threonine protein kinase 0.1117 0.0912 0.2457
Loa Loa (eye worm) TK/FER protein kinase 0.0252 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.003 0.0212
Echinococcus multilocularis tyrosine protein kinase csk 0.0252 0.003 0.003
Echinococcus multilocularis dual specificity 0.1169 0.0965 0.0965
Loa Loa (eye worm) variant SH3 domain-containing protein 0.027 0.0048 0.0048
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0039 0.03
Toxoplasma gondii AGC kinase 0.0723 0.051 0.5163
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0243 0.002 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0238 0.0015 0.0072
Trichomonas vaginalis AGC family protein kinase 0.0302 0.008 0.0703
Echinococcus multilocularis serine:threonine protein kinase N2 0.1871 0.1681 0.1681
Brugia malayi Sex muscle abnormal protein 5 0.0399 0.018 0.018
Brugia malayi Protein kinase domain containing protein 0.6772 0.6684 0.6684
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Loa Loa (eye worm) hypothetical protein 0.0274 0.0052 0.0052
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1403 0.1204 0.1204
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.04 0.018 0.018
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Trichomonas vaginalis CMGC family protein kinase 0.0305 0.0084 0.0734
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Giardia lamblia Kinase, CMGC DYRK 0.0305 0.0084 0.0631
Entamoeba histolytica tyrosine kinase, putative 0.0252 0.003 0.0303
Schistosoma mansoni tyrosine kinase 0.0252 0.003 0.008
Brugia malayi Protein kinase domain containing protein 0.0252 0.003 0.003
Onchocerca volvulus 0.0475 0.0257 0.0385
Schistosoma mansoni serine/threonine protein kinase 0.0408 0.0189 0.0508
Echinococcus multilocularis protein kinase c epsilon type 0.0741 0.0528 0.0528
Entamoeba histolytica cell division protein kinase 2, putative 0.0554 0.0338 0.3443
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0318 0.0097 0.0097
Schistosoma mansoni protein kinase C mu 0.1106 0.0901 0.2428
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0325 0.0104 0.0104
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0706 0.0493 0.0493
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0583 0.0368 0.0368
Loa Loa (eye worm) CAMK protein kinase 0.0407 0.0188 0.0188
Trichomonas vaginalis TK family protein kinase 0.0252 0.003 0.0212
Echinococcus multilocularis rac serine:threonine kinase 0.037 0.015 0.015
Echinococcus multilocularis cyclin dependent kinase 19 0.1771 0.158 0.158
Schistosoma mansoni kinase 0.042 0.0201 0.0541
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.076 0.0548 0.0548
Loa Loa (eye worm) hypothetical protein 0.0707 0.0494 0.0494
Entamoeba histolytica PH domain containing protein kinase, putative 0.037 0.015 0.1532
Plasmodium falciparum tyrosine kinase-like protein 0.0252 0.003 0.0225
Brugia malayi Immunoglobulin I-set domain containing protein 0.0459 0.0241 0.0241
Echinococcus multilocularis protein kinase 0.0252 0.003 0.003
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0825 0.0615 0.0615
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0707 0.0494 0.0486
Schistosoma mansoni hypothetical protein 0.0707 0.0494 0.133
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.024 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0372 0.0153 0.0411
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0789 0.0578 0.0578
Echinococcus granulosus dual specificity mitogen activated protein 0.1242 0.104 0.104
Echinococcus granulosus hypothetical protein 0.0931 0.0723 0.0723
Trypanosoma brucei protein kinase, putative 0.0277 0.0056 0.0048
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.003 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.0785 0.0574 0.1546
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0252 0.003 0.003
Loa Loa (eye worm) TK/RYK protein kinase 0.0252 0.003 0.003
Toxoplasma gondii STE kinase 0.0252 0.003 0.0225
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1103 0.0898 0.0898
Echinococcus granulosus insulin receptor 0.1368 0.1169 0.1169
Onchocerca volvulus 0.6772 0.6684 1
Schistosoma mansoni serine/threonine protein kinase 0.0398 0.0179 0.0482
Brugia malayi casein kinase I 0.0644 0.043 0.043
Schistosoma mansoni tyrosine kinase 0.386 0.3712 1
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.003 0.0212
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0305 0.0084 0.0076
Echinococcus granulosus tyrosine protein kinase Srms 0.0935 0.0727 0.0727
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Leishmania major casein kinase, putative 0.0644 0.043 0.0422
Echinococcus multilocularis casein kinase i 0.0644 0.043 0.043
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0577 0.0361 0.0354
Echinococcus granulosus serine:threonine protein kinase TAO1 0.3097 0.2933 0.2933
Loa Loa (eye worm) TK/ACK protein kinase 0.0252 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0921 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0604 0.0389 0.0389
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Giardia lamblia Kinase, CMGC GSK 0.1184 0.0981 0.9425
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0019 0.0052
Entamoeba histolytica casein kinase 1, putative 0.0644 0.043 0.4378
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0252 0.003 0.0303
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0625 0.0411 0.4184
Echinococcus multilocularis tyrosine protein kinase 0.0252 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.002 0.0054
Trichomonas vaginalis STE family protein kinase 0.0302 0.008 0.0703
Trichomonas vaginalis AGC family protein kinase 0.024 0.0017 0.0092
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0309 0.0088 0.0236
Schistosoma mansoni serine/threonine protein kinase 0.0377 0.0157 0.0423
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0243 0.002 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.1184 0.0981 0.9432
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0398 0.0179 0.1658
Echinococcus multilocularis twitchin 0.0372 0.0153 0.0153
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0252 0.003 0.008
Entamoeba histolytica protein kinase, putative 0.0242 0.0019 0.0196
Loa Loa (eye worm) serine/threonine protein kinase 0.0252 0.003 0.003
Brugia malayi Immunoglobulin I-set domain containing protein 0.3441 0.3284 0.3284
Entamoeba histolytica protein kinase, putative 0.0421 0.0202 0.2057
Echinococcus multilocularis casein kinase I alpha 0.0644 0.043 0.043
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.0052 0.0052
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0228 0.0005 0.0005
Brugia malayi ribosomal protein S6 kinase alpha 3 0.1017 0.081 0.081
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0243 0.002 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0252 0.003 0.0212
Loa Loa (eye worm) hypothetical protein 0.0707 0.0494 0.0494
Brugia malayi Immunoglobulin I-set domain containing protein 0.0274 0.0052 0.0052
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0252 0.003 0.003
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0333 0.0113 0.0113
Echinococcus granulosus titin 0.0407 0.0188 0.0188
Schistosoma mansoni tyrosine kinase 0.2069 0.1884 0.5076
Brugia malayi Protein kinase domain containing protein 0.0366 0.0146 0.0146
Echinococcus granulosus c-Jun N-terminal kinases 0.3206 0.3044 0.3044
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Loa Loa (eye worm) hypothetical protein 0.1707 0.1514 0.1514
Giardia lamblia Kinase, CMGC CK2 0.0261 0.0039 0.0192
Loa Loa (eye worm) TK/FER protein kinase 0.0252 0.003 0.003
Echinococcus multilocularis cyclin dependent kinase 0.0519 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0707 0.0494 0.0494
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0379 0.0159 0.0159
Echinococcus granulosus casein kinase I alpha 0.0644 0.043 0.043
Entamoeba histolytica protein kinase, putative 0.0252 0.003 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0398 0.0179 0.1658
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0252 0.003 0.0212
Loa Loa (eye worm) TK protein kinase 0.0252 0.003 0.003
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2407 0.2229 0.2229
Echinococcus multilocularis cyclin dependent kinase 1 0.0519 0.0302 0.0302
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0377 0.0157 0.0157
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0252 0.003 0.003
Onchocerca volvulus 0.0252 0.003 0.0044
Brugia malayi Protein kinase domain 0.04 0.018 0.018
Echinococcus multilocularis tyrosine protein kinase pr2 0.0252 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0519 0.0302 0.0302
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0309 0.0088 0.0088
Schistosoma mansoni protein kinase 0.0252 0.003 0.008
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0644 0.043 0.043
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0519 0.0302 0.0302
Leishmania major protein kinase, putative 0.0625 0.0411 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.003 0.0212
Brugia malayi bone morphogenetic protein type 1 receptor 0.096 0.0752 0.0752

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.7 uM Inhibition of LPS-stimulated TNF-alpha release in human whole blood ChEMBL. 11472217
IC50 (functional) = 0.7 uM Inhibition of LPS-stimulated TNF-alpha release in human whole blood ChEMBL. 11472217

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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