Detailed information for compound 1557063

Basic information

Technical information
  • TDR Targets ID: 1557063
  • Name: 3-methyl-4-oxido-2-(phenylmethyl)quinoxalin-1 -ium 1-oxide
  • MW: 266.295 | Formula: C16H14N2O2
  • H donors: 0 H acceptors: 2 LogP: 1.58 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1[n+]([O-])c2ccccc2[n+](c1Cc1ccccc1)[O-]
  • InChi: 1S/C16H14N2O2/c1-12-16(11-13-7-3-2-4-8-13)18(20)15-10-6-5-9-14(15)17(12)19/h2-10H,11H2,1H3
  • InChiKey: DKSRBWOIQVNXQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(benzyl)-3-methyl-4-oxido-quinoxalin-1-ium 1-oxide
  • 65990-96-7
  • NSC149312

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0114 0.0522
Mycobacterium ulcerans hypothetical protein 0.0482 0.1126 0.2691
Brugia malayi hypothetical protein 0.0043 0.006 0.0359
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0125 0.0125
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0041 0.0049
Echinococcus multilocularis Niemann Pick C1 protein 0.0278 0.063 0.063
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0036 0.0041 0.0333
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0037 0.0796
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0041 0.0571
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0183 0.1097
Schistosoma mansoni ferritin 0.0027 0.0021 0.0024
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0031 0.014
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0041 0.0247
Mycobacterium ulcerans hypothetical protein 0.0072 0.013 0.029
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.013 0.013
Brugia malayi jmjC domain containing protein 0.007 0.0125 0.0752
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0048 0.0073 0.0174
Echinococcus multilocularis tumor protein p63 0.0671 0.1586 0.1586
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.013 0.0597
Entamoeba histolytica diacylglycerol kinase, putative 0.0067 0.0119 0.0266
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0037 0.0068
Echinococcus granulosus heat shock protein 90 0.0034 0.0037 0.0043
Mycobacterium ulcerans hypothetical protein 0.0121 0.025 0.0579
Echinococcus multilocularis smad 0.0025 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0092 0.0178 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0092 0.0178 0.1067
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0028 0.0392
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.009 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0086 0.0163 0.0359
Brugia malayi phosphofructokinase 0.0112 0.0226 0.1357
Onchocerca volvulus 0.0057 0.0093 0.0767
Loa Loa (eye worm) MBCTL1 0.0065 0.0112 0.0269
Entamoeba histolytica hypothetical protein 0.0039 0.005 0.01
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0036 0.0041 0.0189
Plasmodium vivax diacylglycerol kinase, putative 0.0067 0.0119 0.3242
Entamoeba histolytica hypothetical protein 0.0039 0.005 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0073 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.0178 0.0211
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0036 0.0041 0.0076
Schistosoma mansoni sphingoid long chain base kinase 0.1729 0.4159 0.4946
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0161 0.4411
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.017 0.2588
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.0132 0.0791
Mycobacterium ulcerans heat shock protein 90 0.0027 0.002 0.0025
Loa Loa (eye worm) oxidoreductase 0.0036 0.0041 0.0099
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Loa Loa (eye worm) beta-lactamase 0.0072 0.013 0.0313
Loa Loa (eye worm) endoplasmin 0.0034 0.0037 0.0087
Echinococcus granulosus phosphoglycerate kinase 1 0.0169 0.0365 0.0434
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0036 0.0041 0.0773
Echinococcus granulosus mixed lineage leukemia protein mll 0.0069 0.0122 0.0145
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0222 0.0495 0.0589
Giardia lamblia Phosphoglycerate kinase 0.0169 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.1729 0.4159 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0031 0.003
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.01 0.0458
Echinococcus granulosus expressed protein 0.0027 0.0021 0.0024
Schistosoma mansoni patched 1 0.0083 0.0158 0.0187
Trichomonas vaginalis ap endonuclease, putative 0.006 0.01 0.1489
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Brugia malayi ecdysteroid receptor 0.0092 0.0178 0.1067
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0082 0.0154 0.0183
Loa Loa (eye worm) hypothetical protein 0.0091 0.0175 0.0421
Brugia malayi hypothetical protein 0.0043 0.006 0.0359
Onchocerca volvulus 0.0043 0.006 0.0444
Echinococcus granulosus Niemann Pick C1 protein 0.0278 0.063 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0024 0.0304
Loa Loa (eye worm) hypothetical protein 0.0092 0.0178 0.0426
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0161 0.4187
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0119 0.1781
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0093 0.0425
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0043 0.006 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Brugia malayi RNA, U transporter 1 0.0085 0.0161 0.0968
Plasmodium vivax diacylglycerol kinase, putative 0.0067 0.0119 0.3242
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0039
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0037 0.0167
Loa Loa (eye worm) hypothetical protein 0.0127 0.0263 0.0632
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0121 0.025 0.0568
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.006 0.0444
Schistosoma mansoni zinc finger protein 0.0042 0.0057 0.0068
Brugia malayi Nuclear hormone receptor E75 0.0043 0.006 0.0359
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0031 0.0833
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.0021 0.0015
Schistosoma mansoni apoferritin-2 0.0027 0.0021 0.0024
Echinococcus granulosus tumor protein p63 0.0671 0.1586 0.1886
Echinococcus granulosus GPCR family 2 0.0222 0.0495 0.0589
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0099
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0085 0.0162 0.0162
Toxoplasma gondii hypothetical protein 0.0148 0.0314 0.2536
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.002 0.0161
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0028 0.0768
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0 0.0008
Loa Loa (eye worm) nuclear hormone receptor 0.0043 0.006 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0092 0.0178 0.1067
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.013 0.0782
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0222 0.0495 0.0495
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.0511 0.0607
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0226 0.0525
Loa Loa (eye worm) hypothetical protein 0.0092 0.0178 0.0426
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.017 0.2588
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0041 0.0041
Schistosoma mansoni apoferritin-2 0.0027 0.0021 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0121 0.025 0.1501
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.1076 0.2561
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0114 0.0522
Trichomonas vaginalis bmru protein, putative 0.0067 0.0119 0.1781
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0024 0.0304
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0036 0.0041 0.1134
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0037
Echinococcus multilocularis Niemann Pick C1 protein 0.0194 0.0428 0.0427
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0036 0.0041 0.0076
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0161 0.0365
Echinococcus granulosus lysine specific demethylase 5A 0.0088 0.0168 0.0199
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0043 0.006 0.0071
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.0365 0.1675
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0226 0.0543
Schistosoma mansoni nuclear hormone receptor 0.0092 0.0178 0.0211
Loa Loa (eye worm) hypothetical protein 0.0098 0.0194 0.0465
Schistosoma mansoni zinc finger protein 0.0043 0.006 0.0071
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0014 0.0064
Echinococcus multilocularis protein patched 0.0083 0.0158 0.0157
Onchocerca volvulus 0.0092 0.0178 0.159
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0067 0.0119 0.1781
Onchocerca volvulus 0.0067 0.0119 0.1015
Loa Loa (eye worm) acetyltransferase 0.0295 0.0673 0.1618
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0073 0.0132 0.0132
Schistosoma mansoni cpg binding protein 0.0272 0.0617 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Schistosoma mansoni ferritin 0.0027 0.0021 0.0024
Schistosoma mansoni microtubule-associated protein tau 0.2873 0.6941 0.8254
Loa Loa (eye worm) histone methyltransferase 0.0085 0.0162 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0236 0.0529 0.0629
Onchocerca volvulus 0.0036 0.0041 0.0264
Onchocerca volvulus 0.0036 0.0041 0.0264
Schistosoma mansoni hypothetical protein 0.0358 0.0825 0.0981
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.025 0.6713
Toxoplasma gondii hypothetical protein 0.0029 0.0026 0.0208
Loa Loa (eye worm) hypothetical protein 0.0092 0.0178 0.0426
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0041 0.0247
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0014 0.0385
Trypanosoma cruzi diacylglycerol kinase, putative 0.0067 0.0119 0.0543
Loa Loa (eye worm) hypothetical protein 0.0092 0.0178 0.0426
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.025 0.0579
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0114 0.0273
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0016 0.013
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0041 0.0076
Leishmania major DNA polymerase kappa, putative 0.0023 0.001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Echinococcus multilocularis nuclear receptor nhr 48 0.0043 0.006 0.006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0031 0.003
Mycobacterium tuberculosis Conserved protein 0.0072 0.013 0.028
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0121 0.025 0.0579
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.025 0.1145
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0043 0.006 0.0071
Brugia malayi Probable ClpP-like protease 0.0085 0.0161 0.0968
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0067 0.0119 0.0284
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0161 0.0191
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0031 0.0039
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.0112 0.0133
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0158 0.0187
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0036
Schistosoma mansoni diacylglycerol kinase theta 0.0067 0.0119 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.001 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0093 0.0425
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0037 0.0996
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0161 0.4187
Entamoeba histolytica hypothetical protein 0.0024 0.0014 0.0015
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0037 0.0294
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0041 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0105 0.1566
Onchocerca volvulus Protein ultraspiracle homolog 0.0092 0.0178 0.159
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0006 0.002
Echinococcus multilocularis heat shock protein 90 0.0027 0.002 0.002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0121 0.025 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Plasmodium falciparum importin beta, putative 0.003 0.0027 0.075
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0085 0.0162 0.0193
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.013 0.028
Loa Loa (eye worm) glutaminase 2 0.0283 0.0643 0.1545
Schistosoma mansoni importin beta-1 0.003 0.0027 0.0032
Entamoeba histolytica hypothetical protein 0.0039 0.005 0.01
Onchocerca volvulus 0.0043 0.006 0.0444
Brugia malayi MH2 domain containing protein 0.0025 0.0015 0.0086
Trypanosoma brucei DNA polymerase IV, putative 0.0093 0.018 0.0825
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0092 0.0178 0.0211
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0092 0.0178 0.0211
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.013 0.028
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.0093 0.011
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.017 0.0202
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.0226 0.6032
Echinococcus multilocularis muscleblind protein 0.0149 0.0317 0.0316
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0147 0.4023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0129 0.0268 0.1227
Brugia malayi Bromodomain containing protein 0.0097 0.0191 0.1146
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0016 0.0177
Trichomonas vaginalis ran, putative 0.0022 0.0008 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0092 0.0178 0.1067
Trypanosoma brucei heat shock protein, putative 0.0034 0.0037 0.0167
Leishmania major hypothetical protein, conserved 0.0067 0.0119 0.0543
Onchocerca volvulus 0.0072 0.013 0.1129
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0119 0.0543
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0005 0.001
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0031 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0035 0.0476
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0132 0.0284
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0702 0.1663 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0169 0.0365 0.0846
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0114 0.0522
Echinococcus granulosus microtubule associated protein 2 0.2873 0.6941 0.8254
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0031 0.0246
Schistosoma mansoni Smad4 0.0025 0.0015 0.0017
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.002 0.0329
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0092 0.0178 0.0211
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0028 0.0225
Brugia malayi acetyltransferase, GNAT family protein 0.0295 0.0673 0.4047
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.0365 0.0434
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0041 0.0076
Schistosoma mansoni ferritin light chain 0.0027 0.0021 0.0024
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0048
Schistosoma mansoni ran 0.0022 0.0008 0.0009
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Loa Loa (eye worm) hypothetical protein 0.0121 0.025 0.06
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0915 0.2179 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0105 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0026 0.0331
Loa Loa (eye worm) hypothetical protein 0.0194 0.0428 0.1028
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Loa Loa (eye worm) hypothetical protein 0.0092 0.0178 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.013 0.1964
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0037 0.0167
Trichomonas vaginalis bmru protein, putative 0.0067 0.0119 0.1781
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0092 0.0178 0.1067
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0035 0.0476
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0027 0.0124
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0036 0.0041 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0092 0.0178 0.0426
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0016 0.0074
Schistosoma mansoni hypothetical protein 0.3477 0.8409 1
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0226 0.0525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0092 0.0178 0.0426
Schistosoma mansoni nuclear receptor 0.0043 0.006 0.0071
Loa Loa (eye worm) diacylglycerol kinase 2 0.0067 0.0119 0.0284
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.013 0.1964
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0026 0.0331
Brugia malayi PHD-finger family protein 0.0047 0.007 0.042
Echinococcus granulosus neuropeptide receptor A26 0.0955 0.2278 0.2709
Trypanosoma cruzi Sphingosine kinase 0.0067 0.0119 0.0543
Loa Loa (eye worm) hypothetical protein 0.0048 0.0073 0.0174
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0036 0.0041 0.0247
Echinococcus multilocularis dna polymerase kappa 0.0099 0.0196 0.0196
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.002 0.009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0092 0.0178 0.0211
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0073 0.0132 0.0316
Brugia malayi ImpB/MucB/SamB family protein 0.0125 0.0258 0.1551
Brugia malayi Ceramide kinase 0.0067 0.0119 0.0711
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0014 0.0136
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0092 0.0178 0.0177
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.006 0.0444
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.002 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.0178 0.0177
Echinococcus multilocularis sphingosine kinase 1 0.1729 0.4159 0.4159
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.025 0.1145
Entamoeba histolytica diacylglycerol kinase, putative 0.0067 0.0119 0.0266
Echinococcus granulosus importin subunit beta 1 0.003 0.0027 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0086 0.0163 0.0359
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0069 0.0122 0.0145
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.025 0.6713
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0015 0.0017
Brugia malayi orphan nuclear receptor NR2E1 0.0043 0.006 0.0359
Trichomonas vaginalis dullard protein, putative 0.0025 0.0016 0.0177
Plasmodium vivax hypothetical protein, conserved 0.0072 0.013 0.3563
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0037 0.0167
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0092 0.0178 0.159
Schistosoma mansoni sphingosine kinase A B 0.1729 0.4159 0.4946
Loa Loa (eye worm) hypothetical protein 0.0087 0.0166 0.0399
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.0365 0.1675
Brugia malayi AMP-binding enzyme family protein 0.0121 0.025 0.1501
Trypanosoma brucei heat shock protein, putative 0.0034 0.0037 0.0167
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0092 0.0178 0.0211
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0147 0.3885
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0161 0.4415
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0083 0.0082
Echinococcus multilocularis neuropeptide receptor A26 0.0955 0.2278 0.2278
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.013 0.0155
Brugia malayi Phosphoglycerate kinase 0.0062 0.0105 0.0632
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0036 0.0041 0.0076
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0018
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0043 0.0042
Schistosoma mansoni hypothetical protein 0.008 0.015 0.0179
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.007 0.0125 0.0149
Echinococcus multilocularis GPCR, family 2 0.0222 0.0495 0.0495
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0226 0.3464
Brugia malayi beta-lactamase family protein 0.0072 0.013 0.0782
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0016 0.0019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0092 0.0178 0.0211
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0114 0.0135
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0037 0.0167
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.01 0.2442
Loa Loa (eye worm) hypothetical protein 0.0072 0.013 0.0313
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0014 0.0064
Echinococcus granulosus cpg binding protein 0.029 0.0659 0.0784
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0028 0.0761
Trichomonas vaginalis set domain proteins, putative 0.0242 0.0543 0.8434
Echinococcus multilocularis zinc finger protein 0.0042 0.0057 0.0057
Trypanosoma brucei heat shock protein, putative 0.0034 0.0037 0.0167
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0008 0.0009
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0037 0.0087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0092 0.0178 0.0211
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0222 0.0495 0.0589
Echinococcus multilocularis 0.0025 0.0016 0.0016
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0295 0.0673 0.0673
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0036 0.0041 0.0076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0079 0.0148 0.0322
Schistosoma mansoni steroid hormone receptor ad4bp 0.0092 0.0178 0.0211
Loa Loa (eye worm) hypothetical protein 0.0057 0.0093 0.0223
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0129 0.0268 0.1227
Schistosoma mansoni coup transcription factor 0.0092 0.0178 0.0211
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.013 0.028
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0091 0.0175 0.0399
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.007 0.0125 0.0125
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.001 0.0077
Plasmodium vivax acyl-CoA synthetase, putative 0.0091 0.0175 0.4795
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.025 0.0568
Leishmania major GTP-binding protein, putative 0.0022 0.0008 0.0036
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.013 0.028
Loa Loa (eye worm) hypothetical protein 0.048 0.1122 0.2698
Loa Loa (eye worm) ceramide kinase 0.0067 0.0119 0.0284
Trypanosoma brucei heat shock protein, putative 0.0034 0.0037 0.0167
Loa Loa (eye worm) hypothetical protein 0.0091 0.0175 0.0421
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.0021 0.0015
Schistosoma mansoni hypothetical protein 0.0222 0.0495 0.0589
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0016 0.0019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0092 0.0178 0.0211
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0226 0.3464
Brugia malayi hypothetical protein 0.0067 0.0119 0.0711
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.013 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0093 0.0425
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0161 0.4187
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0041 0.0076
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0079 0.0148 0.0677
Plasmodium vivax endoplasmin, putative 0.0034 0.0037 0.0996
Echinococcus multilocularis expressed protein 0.0027 0.0021 0.002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.073 0.1754
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0021 0.0181
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0073 0.0132 0.0156
Loa Loa (eye worm) hypothetical protein 0.0053 0.0083 0.0198
Trypanosoma brucei unspecified product 0.005 0.0077 0.0352
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0114 0.0135
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0041 0.0189
Schistosoma mansoni terminal deoxycytidyl transferase 0.0073 0.0132 0.0156
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0047 0.0047
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0093 0.011
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0166 0.0999
Loa Loa (eye worm) nuclear receptor NHR-67 0.0043 0.006 0.0143
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0028 0.0556
Brugia malayi nuclear receptor NHR-88 0.0043 0.006 0.0359
Trypanosoma cruzi diacylglycerol kinase, putative 0.0067 0.0119 0.0543
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0226 0.0268
Brugia malayi Phosphoglycerate kinase 0.0169 0.0365 0.2194
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.002 0.009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0222 0.0495 0.119
Trypanosoma brucei heat shock protein, putative 0.0034 0.0037 0.0167
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0226 0.3464
Brugia malayi hypothetical protein 0.0447 0.1042 0.6265
Schistosoma mansoni hypothetical protein 0.008 0.015 0.0179
Echinococcus granulosus zinc finger protein 0.0042 0.0057 0.0068
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0037 0.0294
Loa Loa (eye worm) hypothetical protein 0.0048 0.0073 0.0174
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0028 0.0392
Brugia malayi Niemann-Pick C1 protein precursor 0.0194 0.0428 0.257
Loa Loa (eye worm) hypothetical protein 0.0092 0.0178 0.0426
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0028 0.0225
Echinococcus multilocularis Smad4 0.0025 0.0015 0.0014
Plasmodium vivax acetyl-CoA synthetase, putative 0.0036 0.0041 0.1128
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0092 0.0178 0.1067
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Echinococcus multilocularis heat shock protein 90 0.0034 0.0037 0.0036
Onchocerca volvulus 0.0272 0.0617 0.5866
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0092 0.0178 0.1067
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0043 0.005
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0014 0.0392
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0048 0.0073 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0028 0.0362
Trypanosoma brucei Sphingosine kinase 0.0067 0.0119 0.0543
Brugia malayi conserved hypotetical protein 0.0043 0.006 0.0359
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0016 0.0177
Brugia malayi tailless protein 0.0043 0.006 0.0359
Schistosoma mansoni hypothetical protein 0.008 0.015 0.0179
Schistosoma mansoni hypothetical protein 0.0222 0.0495 0.0589
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0036 0.0041 0.0065
Brugia malayi steroid hormone receptor 0.0092 0.0178 0.1067
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0226 0.0268
Schistosoma mansoni hypothetical protein 0.0498 0.1167 0.1387
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0038 0.0047 0.0047
Echinococcus multilocularis Diacylglycerol kinase theta 0.0067 0.0119 0.0118
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0031 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0158 0.2394
Plasmodium falciparum diacylglycerol kinase, putative 0.0067 0.0119 0.3247
Brugia malayi diacylglycerol kinase 0.0067 0.0119 0.0711
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0336 0.1541
Leishmania major DNA polymerase eta, putative 0.0125 0.0258 0.1183
Schistosoma mansoni jumonji domain containing protein 0.007 0.0125 0.0149
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.01 0.0119
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0092 0.0178 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0092 0.0178 0.1067
Brugia malayi 6-phosphofructokinase 0.0112 0.0226 0.1357
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0008 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0226 0.3464
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.001 0.0043
Echinococcus granulosus dna polymerase kappa 0.0099 0.0196 0.0233
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0136 0.0623
Onchocerca volvulus 0.0036 0.0042 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0148 0.0677
Loa Loa (eye worm) RecQ helicase 0.0021 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.0511 0.0511
Echinococcus multilocularis endoplasmin 0.0027 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0067 0.0119 0.0284
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0114 0.0684
Plasmodium vivax SET domain protein, putative 0.0036 0.0042 0.1132
Schistosoma mansoni thyroid hormone receptor 0.0092 0.0178 0.0211
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Echinococcus granulosus Smad4 0.0025 0.0015 0.0017
Trypanosoma brucei unspecified product 0.005 0.0077 0.0352
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.013 0.029
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0062 0.0105 0.1566
Schistosoma mansoni ferritin 0.0027 0.0021 0.0024
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0016 0.0439
Schistosoma mansoni myst-related protein 0.0034 0.0038 0.0044
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.0226 0.0226
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0015 0.0035
Echinococcus granulosus geminin 0.0498 0.1167 0.1387
Loa Loa (eye worm) CXXC zinc finger family protein 0.0272 0.0617 0.1483
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0015 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.0196 0.0898
Brugia malayi hypothetical protein 0.0039 0.005 0.0298
Schistosoma mansoni jumonji/arid domain-containing protein 0.0088 0.0168 0.0199
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.013 0.1964
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0038 0.0047 0.0055
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.001 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0702 0.1663 1
Schistosoma mansoni nuclear hormone receptor 0.0043 0.006 0.0071
Echinococcus multilocularis expressed conserved protein 0.0183 0.0399 0.0399
Schistosoma mansoni smad1 5 8 and 0.0025 0.0015 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0225
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.017 0.1375
Schistosoma mansoni ap endonuclease 0.006 0.01 0.0119
Trypanosoma brucei heat shock protein, putative 0.0034 0.0037 0.0167
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Onchocerca volvulus Ceramide kinase 1 homolog 0.0067 0.0119 0.1015
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0036
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.0021 0.0181
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0067 0.0119 0.0118
Schistosoma mansoni ran 0.0022 0.0008 0.0009
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.001 0.0043
Trichomonas vaginalis esterase, putative 0.0072 0.013 0.1964
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0114 0.0114
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0069 0.0122 0.0122
Mycobacterium tuberculosis Conserved hypothetical protein 0.0482 0.1126 0.2683
Schistosoma mansoni survival motor neuron protein 0.0094 0.0183 0.0217
Echinococcus granulosus snurportin 1 0.0319 0.073 0.0867
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.001 0.0043
Echinococcus multilocularis importin subunit beta 1 0.003 0.0027 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.01 0.0458
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0086 0.0163 0.0359
Echinococcus multilocularis dnaJ subfamily B 0.3477 0.8409 0.8409
Plasmodium falciparum zinc finger protein, putative 0.0034 0.0038 0.1028
Brugia malayi CHE-14 protein 0.0083 0.0158 0.0947
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0031 0.003
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.013 0.0155
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0433 0.1007 0.4623
Mycobacterium ulcerans acetyl-CoA synthetase 0.0036 0.0041 0.0076
Brugia malayi SET domain containing protein 0.0024 0.0014 0.0084
Loa Loa (eye worm) Smad1 0.0025 0.0015 0.0034
Onchocerca volvulus 0.0094 0.0183 0.1638
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0031 0.014
Onchocerca volvulus Huntingtin homolog 0.0127 0.0263 0.2422
Loa Loa (eye worm) hypothetical protein 0.0065 0.0112 0.0269
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0041 0.0773
Mycobacterium ulcerans phosphoglycerate kinase 0.0169 0.0365 0.0856
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0226 0.1036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0041 0.0247
Onchocerca volvulus 0.0242 0.0543 0.5145
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0236 0.0529 0.0529
Brugia malayi 6-phosphofructokinase 0.0112 0.0226 0.1357
Loa Loa (eye worm) hypothetical protein 0.0065 0.0113 0.0271
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0028 0.0362
Echinococcus granulosus thyroid hormone receptor alpha 0.0043 0.006 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Echinococcus multilocularis phosphoglycerate kinase 1 0.0169 0.0365 0.0365
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.0226 0.0511
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0105 0.0483
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0016 0.0439
Echinococcus granulosus muscleblind protein 0.0149 0.0317 0.0376
Leishmania major mitochondrial DNA polymerase beta 0.0915 0.2179 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.005 0.0059
Schistosoma mansoni hypothetical protein 0.0319 0.073 0.0867
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.01 0.0458
Loa Loa (eye worm) phosphofructokinase 0.0112 0.0226 0.0543
Plasmodium vivax phosphoglycerate kinase, putative 0.0169 0.0365 1
Mycobacterium ulcerans beta-lactamase 0.0072 0.013 0.029
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0074 0.0338
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0702 0.1663 0.3998
Brugia malayi Diacylglycerol kinase protein 2 0.0067 0.0119 0.0711
Brugia malayi Muscleblind-like protein 0.0149 0.0317 0.1902
Brugia malayi MH2 domain containing protein 0.0025 0.0015 0.0086
Loa Loa (eye worm) MH2 domain-containing protein 0.0361 0.0832 0.1999
Onchocerca volvulus 0.0447 0.1042 1
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.002 0.009
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0105 0.0483
Loa Loa (eye worm) hypothetical protein 0.0091 0.0175 0.0421
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0036 0.0041 0.0076
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0006 0.002
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0433 0.1007 0.4623
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.006 0.0071
Giardia lamblia Grp94/Hsp90 0.0027 0.002 0.0329
Entamoeba histolytica phosphoglycerate kinase, putative 0.0169 0.0365 0.086
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0069 0.0122 0.0122
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0016 0.0177
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.009 0.009
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0067 0.0119 0.1781
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0166 0.0198
Schistosoma mansoni hypothetical protein 0.0222 0.0495 0.0589
Schistosoma mansoni smad 0.0025 0.0015 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0015 0.0034
Schistosoma mansoni ferritin 0.0027 0.0021 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0028 0.0362
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0092 0.0178 0.0177
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0026 0.0703
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0067 0.0119 0.0543
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0075 0.0136 0.1099
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0043 0.006 0.006
Schistosoma mansoni bromodomain containing protein 0.0085 0.0163 0.0193
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0166 0.0166
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.0196 0.0898
Loa Loa (eye worm) hypothetical protein 0.0083 0.0158 0.0379
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0027 0.0219
Echinococcus granulosus ceramide kinase 0.0067 0.0119 0.0141
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0092 0.0178 0.0177
Giardia lamblia DNA damage repair protein 0.0023 0.001 0.0043
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.013 0.028
Brugia malayi nuclear receptor NHR-88 0.0092 0.0178 0.1067
Mycobacterium ulcerans hypothetical protein 0.1729 0.4159 1
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0067 0.0119 0.0958
Brugia malayi heat shock protein 90 0.0034 0.0037 0.0219
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0041 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0024 0.0304
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0031 0.003
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.009 0.0183
Echinococcus granulosus nuclear receptor nhr 48 0.0043 0.006 0.0071
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0105 0.0483
Leishmania major DNA polymerase kappa, putative 0.0079 0.0148 0.0677
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0092 0.0178 0.0426
Leishmania major importin beta-1 subunit, putative 0.0024 0.0014 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0036 0.0041 0.0333
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0067 0.0119 0.0543
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0093 0.0093
Plasmodium falciparum acyl-CoA synthetase 0.0091 0.0175 0.4799
Loa Loa (eye worm) hypothetical protein 0.0102 0.0203 0.0488
Loa Loa (eye worm) hypothetical protein 0.0072 0.013 0.0313
Loa Loa (eye worm) hypothetical protein 0.003 0.0027 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0041 0.0247
Loa Loa (eye worm) hypothetical protein 0.0092 0.0178 0.0426
Leishmania major DNA polymerase eta, putative 0.0075 0.0136 0.0623
Loa Loa (eye worm) hypothetical protein 0.0125 0.0258 0.062
Onchocerca volvulus 0.0072 0.013 0.1129
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.0112 0.0674
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0433 0.1007 0.4623
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0092 0.0178 0.1067
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0015 0.0034
Brugia malayi nuclear hormone receptor family member nhr-6 0.0043 0.006 0.0359
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0031 0.0036
Entamoeba histolytica hypothetical protein 0.0034 0.0038 0.0071
Schistosoma mansoni cpg binding protein 0.029 0.0659 0.0784
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.017 0.1375
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.013 0.028
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Trypanosoma cruzi Sphingosine kinase 0.0067 0.0119 0.0543
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0099
Schistosoma mansoni retinoic acid receptor RXR 0.0092 0.0178 0.0211
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0122 0.0145
Schistosoma mansoni ap endonuclease 0.006 0.01 0.0119
Loa Loa (eye worm) hypothetical protein 0.0222 0.0495 0.119
Trichomonas vaginalis glutaminase, putative 0.0283 0.0643 1
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0067 0.0119 0.0141
Echinococcus granulosus expressed conserved protein 0.0183 0.0399 0.0474
Echinococcus granulosus ecdysone induced protein 78C 0.0092 0.0178 0.0211
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0092 0.0178 0.0211
Entamoeba histolytica deoxycytidyl transferase, putative 0.0073 0.0132 0.0298
Chlamydia trachomatis phosphoglycerate kinase 0.0169 0.0365 1
Leishmania major sphingosine kinase A, B, putative 0.0067 0.0119 0.0543
Loa Loa (eye worm) hypothetical protein 0.0149 0.0317 0.0761
Echinococcus multilocularis neuropeptide s receptor 0.0955 0.2278 0.2278
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0041 0.0189
Echinococcus granulosus Diacylglycerol kinase zeta 0.0067 0.0119 0.0141
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.0021 0.0026
Onchocerca volvulus Bile acid receptor homolog 0.0092 0.0178 0.159
Brugia malayi Nuclear hormone receptor E75 0.0043 0.006 0.0359
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0194 0.0428 0.101
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0008 0.0008
Mycobacterium ulcerans glutaminase 0.0283 0.0643 0.1526
Brugia malayi hypothetical protein 0.0459 0.1072 0.6444
Echinococcus granulosus ferritin 0.0027 0.0021 0.0024
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0226 0.0525
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0915 0.2179 1
Echinococcus multilocularis heat shock protein 0.0034 0.0037 0.0036
Brugia malayi Importin beta-1 subunit 0.003 0.0027 0.0163
Onchocerca volvulus 0.0072 0.013 0.1129
Entamoeba histolytica acyl-coA synthetase, putative 0.0121 0.025 0.0582
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.001 0.0043
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0031 0.084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.006 0.0071
Trichomonas vaginalis hypothetical protein 0.0033 0.0035 0.0476
Echinococcus granulosus neuropeptide s receptor 0.0955 0.2278 0.2709
Onchocerca volvulus 0.0098 0.0194 0.1745
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0114 0.0255
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.0365 0.0434
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0008 0.0218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Schistosoma mansoni hypothetical protein 0.0222 0.0495 0.0589
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0158 0.0187
Schistosoma mansoni hypothetical protein 0.048 0.1122 0.1334
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0042 0.0334
Brugia malayi Endoplasmin precursor 0.0034 0.0037 0.0219
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0029 0.0036
Trypanosoma cruzi DNA polymerase eta, putative 0.0125 0.0258 0.1183
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0026 0.0206
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0067 0.0119 0.0543
Trypanosoma brucei unspecified product 0.0093 0.018 0.0825
Brugia malayi diacylglycerol kinase 0.0067 0.0119 0.0711
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0048 0.0073 0.0086
Schistosoma mansoni glutaminase 0.0283 0.0643 0.0764
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0041 0.0189
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0099 0.0196 0.2994
Brugia malayi MH1 domain containing protein 0.0025 0.0015 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0028 0.0362
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0036 0.0041 0.0076
Schistosoma mansoni endoplasmin 0.0034 0.0037 0.0043
Schistosoma mansoni endoplasmin 0.0034 0.0037 0.0043
Echinococcus granulosus FTZ F1 alpha 0.0092 0.0178 0.0211
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0036 0.0041 0.008
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0158 0.0379
Schistosoma mansoni hypothetical protein 0.0498 0.1167 0.1387
Trichomonas vaginalis diacylglycerol kinase, putative 0.0067 0.0119 0.1781
Trichomonas vaginalis sphingosine kinase, putative 0.0067 0.0119 0.1781
Schistosoma mansoni jumonji/arid domain-containing protein 0.0088 0.0168 0.0199
Loa Loa (eye worm) hypothetical protein 0.0072 0.013 0.0313
Brugia malayi Pre-SET motif family protein 0.0213 0.0473 0.2845
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.0196 0.0449
Echinococcus granulosus Niemann Pick C1 protein 0.0194 0.0428 0.0508
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0073 0.0435
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0161 0.4187
Brugia malayi nuclear hormone receptor 0.0043 0.006 0.0359
Entamoeba histolytica hypothetical protein, conserved 0.1729 0.4159 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0073 0.0174
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0041 0.0065
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0027 0.0124
Echinococcus granulosus fetal alzheimer antigen falz 0.0038 0.0047 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0014 0.0114
Loa Loa (eye worm) jmjC domain-containing protein 0.0088 0.0168 0.0403
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0031 0.0183
Echinococcus granulosus heat shock protein 0.0034 0.0037 0.0043
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0067 0.0119 0.0543
Schistosoma mansoni myst-related protein 0.0034 0.0038 0.0044
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.013 0.028
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0226 0.1036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0082 0.0154 0.0154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.0511 0.0511
Brugia malayi nuclear receptor NHR-67 0.0043 0.006 0.0359
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0036 0.0041 0.0041
Mycobacterium leprae Probable lipase LipE 0.0072 0.013 0.3306
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0158 0.0157
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.013 0.0313
Toxoplasma gondii histone lysine methyltransferase SET1 0.0527 0.1235 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0041 0.0065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0222 0.0495 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0016 0.0096
Echinococcus multilocularis snurportin 1 0.0319 0.073 0.0729
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0014 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0229 0.0511 0.3071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0042 0.0049
Loa Loa (eye worm) hypothetical protein 0.0447 0.1042 0.2505
Loa Loa (eye worm) hypothetical protein 0.0459 0.1072 0.2576
Loa Loa (eye worm) hypothetical protein 0.0092 0.0178 0.0426
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.006 0.006
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0028 0.0048
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Loa Loa (eye worm) hypothetical protein 0.0049 0.0074 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0083 0.0098
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0042 0.0041
Leishmania major hypothetical protein, conserved 0.0067 0.0119 0.0543
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.01 0.0217
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0041 0.0099
Trypanosoma brucei DNA polymerase eta, putative 0.0125 0.0258 0.1183
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0105 0.0483
Toxoplasma gondii propionate-CoA ligase 0.0036 0.0041 0.0333
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0014 0.0011
Toxoplasma gondii exonuclease III APE 0.006 0.01 0.0807
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.01 0.2733
Trypanosoma brucei diacylglycerol kinase, putative 0.0067 0.0119 0.0543
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0028 0.0362
Trypanosoma brucei heat shock protein, putative 0.0034 0.0037 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0074 0.0338
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0028 0.0761
Echinococcus granulosus smad 0.0025 0.0015 0.0017
Mycobacterium ulcerans lipase LipD 0.0072 0.013 0.029
Brugia malayi mbt repeat family protein 0.0057 0.0093 0.0558
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.01 0.2571
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0092 0.0178 0.0426
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0226 0.0543
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.0112 0.0133
Loa Loa (eye worm) hypothetical protein 0.0091 0.0175 0.0421
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0041 0.0065
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0119 0.0543
Loa Loa (eye worm) hypothetical protein 0.0072 0.013 0.0313
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0169 0.0365 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0031 0.014
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.1729 0.4159 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.013 0.028
Trichomonas vaginalis ferritin, putative 0.0027 0.0021 0.0246
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0073 0.0132 0.0156
Trichomonas vaginalis ap endonuclease, putative 0.006 0.01 0.1489
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0161 0.0191
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0028 0.0392
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0041 0.0247
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0006 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0073 0.0435
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Brugia malayi nuclear receptor RXR 0.0043 0.006 0.0359
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0093 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0028 0.0362
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0067 0.0119 0.0141
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0169 0.0365 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0041 0.0076
Brugia malayi nuclear hormone receptor 0.0092 0.0178 0.1067
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0016 0.0074
Brugia malayi AMP-binding enzyme family protein 0.0121 0.025 0.1501
Leishmania major hypothetical protein, conserved 0.0025 0.0016 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.013 0.0155
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0016 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0014 0.0136
Loa Loa (eye worm) hypothetical protein 0.0067 0.0119 0.0284
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.025 0.0582
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.001 0.0011
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.0112 0.0133
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0015 0.0017
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.0226 0.0521
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.0021 0.0026
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.017 0.4653
Loa Loa (eye worm) hypothetical protein 0.0085 0.0161 0.0387
Brugia malayi Bromodomain containing protein 0.0045 0.0065 0.0387
Plasmodium falciparum phosphoglycerate kinase 0.0169 0.0365 1
Brugia malayi polk-prov protein 0.0049 0.0074 0.0443
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0194 0.023
Schistosoma mansoni nuclear receptor nhr-48 0.0043 0.006 0.0071
Brugia malayi latrophilin 2 splice variant baaae 0.048 0.1122 0.6749
Trichomonas vaginalis heat shock protein, putative 0.0027 0.002 0.0235
Echinococcus multilocularis ceramide kinase 0.0067 0.0119 0.0118
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0161 0.1303
Mycobacterium leprae conserved hypothetical protein 0.0072 0.013 0.3306
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.01 0.06
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Onchocerca volvulus Huntingtin homolog 0.0127 0.0263 0.2422
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0036 0.0041 0.0773
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0092 0.0178 0.1067
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0016 0.0177
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.01 0.0458
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0067 0.0119 0.0118
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0037 0.0496
Trypanosoma brucei ISWI complex protein 0.0029 0.0024 0.011
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0161 0.0365
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0041 0.0065
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0005
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0105 0.0483
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.0511 0.0607
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.0365 0.5646
Plasmodium vivax importin-beta 2, putative 0.003 0.0027 0.0743
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.01 0.2442
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.0112 0.0112
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0915 0.2179 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0105 0.0483
Echinococcus multilocularis ferritin 0.0027 0.0021 0.002
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0037 0.0167
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.0093 0.011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.006 0.006
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0041 0.0099
Toxoplasma gondii diacylglycerol kinase, putative 0.0067 0.0119 0.0958
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.0365 0.1675
Loa Loa (eye worm) hypothetical protein 0.0127 0.0263 0.0632
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.006 0.006
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0031 0.014
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0016 0.0446
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0031 0.014
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0041 0.0189
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0031 0.0036
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.0226 0.6032
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0196 0.0898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.0511 0.0607
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.013 0.0597
Brugia malayi jmjC domain containing protein 0.0088 0.0168 0.1007
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0036 0.0041 0.0065
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0037 0.0167
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.006 0.0071
Loa Loa (eye worm) hypothetical protein 0.007 0.0125 0.0301
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0037 0.0167
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0317 0.0316
Brugia malayi hypothetical protein 0.0048 0.0073 0.0435
Loa Loa (eye worm) hypothetical protein 0.0091 0.0175 0.0421
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0015 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.001 0.0043
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0121 0.025 0.0579
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0105 0.1566
Onchocerca volvulus 0.0121 0.025 0.2292
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.0226 0.1036
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0062 0.0105 0.1566
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0041 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.025 0.1145
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0093 0.011
Loa Loa (eye worm) hypothetical protein 0.0149 0.0317 0.0761
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0067 0.0119 0.0141
Trichomonas vaginalis helicase, putative 0.0062 0.0105 0.1566
Echinococcus granulosus dnaJ subfamily B 0.3477 0.8409 1
Trichomonas vaginalis heat shock protein, putative 0.0027 0.002 0.0235
Echinococcus granulosus endoplasmin 0.0027 0.002 0.0023
Echinococcus multilocularis protein dispatched 1 0.0095 0.0186 0.0186
Entamoeba histolytica hypothetical protein 0.0024 0.0014 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0092 0.0178 0.0426
Loa Loa (eye worm) steroid hormone receptor 0.0092 0.0178 0.0426
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0036 0.0041 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0092 0.0178 0.0426
Toxoplasma gondii ABC1 family protein 0.0072 0.013 0.1053
Trichomonas vaginalis DNA polymerase eta, putative 0.0099 0.0196 0.2994
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0043 0.006 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0161 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.0178 0.0211
Echinococcus multilocularis cpg binding protein 0.029 0.0659 0.0659
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0036 0.0041 0.0076
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.0093 0.0223
Brugia malayi nuclear receptor RXR 0.0048 0.0073 0.0435
Brugia malayi beta-lactamase 0.0072 0.013 0.0782
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0014 0.0061
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Treponema pallidum phosphoglycerate kinase 0.0169 0.0365 1
Brugia malayi beta-lactamase family protein 0.0072 0.013 0.0782
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0047 0.0055
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.0365 0.5646
Echinococcus multilocularis microtubule associated protein 2 0.2873 0.6941 0.6941
Loa Loa (eye worm) hypothetical protein 0.0048 0.0073 0.0174
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0129 0.0268 0.1227
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.001 0.0043
Trichomonas vaginalis dullard protein, putative 0.0025 0.0016 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.025 0.0579
Entamoeba histolytica hypothetical protein 0.0039 0.005 0.01
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.013 0.0597
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0092 0.0178 0.0177
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0037 0.0068
Onchocerca volvulus 0.0036 0.0041 0.0264
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0016 0.0019
Brugia malayi nuclear hormone receptor family member odr-7 0.0043 0.006 0.0359
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.013 0.1964
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.01 0.024
Schistosoma mansoni heat shock protein 0.0034 0.0037 0.0043
Mycobacterium ulcerans diacylglycerol kinase 0.0067 0.0119 0.0262
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.0073 0.0086
Plasmodium falciparum endoplasmin, putative 0.0021 0.0005 0.0136
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0016 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0229 0.0511 0.1228
Onchocerca volvulus 0.0087 0.0166 0.148
Schistosoma mansoni ferritin light chain 0.0027 0.0021 0.0024
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.002 0.0023
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.0196 0.0449
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.013 0.1964
Brugia malayi Nuclear hormone receptor-like 1 0.0092 0.0178 0.1067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0473 0.1137
Loa Loa (eye worm) DR-78 0.0043 0.006 0.0143
Echinococcus granulosus survival motor neuron protein 1 0.0459 0.1072 0.1274
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0041 0.0076
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0579 0.1362 0.162
Entamoeba histolytica diacylglycerol kinase, putative 0.0067 0.0119 0.0266
Echinococcus granulosus heat shock protein 90 0.0027 0.002 0.0023
Brugia malayi hypothetical protein 0.0127 0.0263 0.1581
Brugia malayi Latrophilin receptor protein 2 0.0222 0.0495 0.2977
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0016 0.0016
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0041 0.0189
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Schistosoma mansoni acetyl-CoA synthetase 0.0036 0.0041 0.0049
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0028 0.0768
Brugia malayi mbt repeat family protein 0.0057 0.0093 0.0558
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0161 0.1303
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0036 0.0041 0.0065
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0105 0.0483
Brugia malayi MH2 domain containing protein 0.0361 0.0832 0.5001
Echinococcus granulosus bloom syndrome protein 0.0021 0.0006 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0014 0.0136
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.002 0.0161
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0015 0.0014
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0016 0.0226
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0105 0.1566
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0043 0.006 0.0143
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0091 0.0175 0.0388
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0121 0.025 0.0579
Brugia malayi Eye-specific diacylglycerol kinase 0.0067 0.0119 0.0711
Trypanosoma brucei heat shock protein, putative 0.0034 0.0037 0.0167
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0067 0.0119 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0083 0.0098
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.009 0.0183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.004 0.0052 0.0062
Loa Loa (eye worm) hypothetical protein 0.0121 0.025 0.06
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0129 0.0268 0.1227
Loa Loa (eye worm) hypothetical protein 0.0702 0.1663 0.3998
Leishmania major diacylglycerol kinase-like protein 0.0067 0.0119 0.0543
Echinococcus multilocularis FTZ F1 alpha 0.0092 0.0178 0.0177
Schistosoma mansoni heat shock protein 0.0034 0.0037 0.0043
Schistosoma mansoni bromodomain containing protein 0.0027 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.001 0.0043
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0041 0.0189
Schistosoma mansoni nuclear receptor 0.0043 0.006 0.0071
Echinococcus granulosus histone acetyltransferase KAT2B 0.0285 0.0647 0.077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0042 0.0049
Schistosoma mansoni hypothetical protein 0.0067 0.0119 0.0141
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.01 0.2738
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0041 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.0178 0.0177
Brugia malayi glutaminase DH11.1 0.0283 0.0643 0.3865
Loa Loa (eye worm) glutaminase 0.0283 0.0643 0.1545
Trichomonas vaginalis heat shock protein, putative 0.0027 0.002 0.0235
Loa Loa (eye worm) hypothetical protein 0.0121 0.025 0.06
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0197 0.0435 0.0517
Entamoeba histolytica diacylglycerol kinase, putative 0.0067 0.0119 0.0266
Schistosoma mansoni hypothetical protein 0.0039 0.005 0.0059
Echinococcus granulosus sphingosine kinase 1 0.1729 0.4159 0.4946
Loa Loa (eye worm) hypothetical protein 0.0072 0.013 0.0313
Treponema pallidum heat shock protein 90 0.0027 0.002 0.0161
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0027 0.0021 0.0181
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0037 0.0167
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.0226 0.0268
Echinococcus multilocularis geminin 0.0498 0.1167 0.1166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0105 0.1566
Schistosoma mansoni hypothetical protein 0.0094 0.0183 0.0217
Leishmania major phosphoglycerate kinase B, cytosolic 0.0169 0.0365 0.1675
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.0365 0.1675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.0511 0.0607
Loa Loa (eye worm) hypothetical protein 0.0169 0.0365 0.0877
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0091 0.0175 0.4587
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0083 0.0098
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0036 0.0041 0.0049
Echinococcus multilocularis thyroid hormone receptor alpha 0.0092 0.0178 0.0177
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0024 0.0029
Leishmania major diacylglycerol kinase, putative 0.0067 0.0119 0.0543
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.025 0.0582
Echinococcus multilocularis ecdysone induced protein 78C 0.0092 0.0178 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0041 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.025 0.0579
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0028 0.0362
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.01 0.0207
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0143
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0031 0.0246
Loa Loa (eye worm) hypothetical protein 0.0072 0.013 0.0313
Schistosoma mansoni hypothetical protein 0.008 0.015 0.0179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0222 0.0495 0.2977
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0161 0.4187
Giardia lamblia DINP protein human, muc B family 0.0079 0.0148 0.391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0092 0.0178 0.0426
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.0093 0.0767
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0105 0.1566
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.009 0.216
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0092 0.0178 0.1067
Onchocerca volvulus 0.0043 0.006 0.0447
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.005 0.0059
Echinococcus granulosus dna polymerase eta 0.0125 0.0258 0.0307
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0048 0.0073 0.0072
Mycobacterium tuberculosis Diacylglycerol kinase 0.0067 0.0119 0.0252
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0114 0.0522
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0036 0.0041 0.0065
Brugia malayi Pre-SET motif family protein 0.0036 0.0042 0.0248
Echinococcus granulosus Diacylglycerol kinase theta 0.0067 0.0119 0.0141
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Echinococcus multilocularis dna polymerase eta 0.0125 0.0258 0.0258
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0092 0.0178 0.0211
Schistosoma mansoni diacylglycerol kinase theta 0.0067 0.0119 0.0141
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0295 0.0673 0.08
Schistosoma mansoni SET domain protein 0.0024 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.007 0.0169
Plasmodium falciparum diacylglycerol kinase, putative 0.0067 0.0119 0.3247
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0003 0.0013
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0041 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Plasmodium falciparum heat shock protein 90 0.0034 0.0037 0.1003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0092 0.0178 0.0211
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.001 0.0267
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0036 0.0041 0.0065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0047 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0041 0.0076
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0014 0.0114
Mycobacterium tuberculosis Conserved protein 0.0072 0.013 0.028
Brugia malayi isocitrate dehydrogenase 0.0031 0.0031 0.0183
Trichomonas vaginalis dullard protein, putative 0.0025 0.0016 0.0177
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.01 0.0221
Brugia malayi MH1 domain containing protein 0.0025 0.0015 0.0086
Schistosoma mansoni RAR-like nuclear receptor 0.0092 0.0178 0.0211
Trypanosoma cruzi ISWI complex protein 0.0029 0.0024 0.011
Brugia malayi ecdysone receptor 0.0043 0.006 0.0359
Brugia malayi CXXC zinc finger family protein 0.0272 0.0617 0.371
Schistosoma mansoni smad1 5 8 and 0.0025 0.0015 0.0017
Schistosoma mansoni DNA polymerase eta 0.0125 0.0258 0.0307
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0169 0.0365 0.2954
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0166 0.0198
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0026 0.071
Brugia malayi Steroid receptor seven-up type 2 0.0092 0.0178 0.1067
Echinococcus multilocularis survival motor neuron protein 1 0.0459 0.1072 0.1071
Schistosoma mansoni smad1 5 8 and 0.0025 0.0015 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.0511 0.0607
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0043 0.006 0.0071
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0028 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0092 0.0178 0.1067
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.001 0.026
Schistosoma mansoni thyroid hormone receptor 0.0092 0.0178 0.0211
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0067 0.0119 0.1781
Brugia malayi hypothetical protein 0.0048 0.0073 0.0435
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0086 0.0163 0.0359
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Brugia malayi Smad1 0.0025 0.0015 0.0086
Leishmania major hypothetical protein, conserved 0.0072 0.013 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0092 0.0178 0.1067
Brugia malayi F/Y-rich N-terminus family protein 0.0086 0.0164 0.0987
Leishmania major DNA damage repair protein, putative 0.0023 0.001 0.0043
Trichomonas vaginalis sphingosine kinase, putative 0.0067 0.0119 0.1781
Schistosoma mansoni nuclear hormone receptor 0.0043 0.006 0.0071
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0147 0.0334
Leishmania major heat shock protein 83-1 0.0034 0.0037 0.0167
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0169 0.0365 0.2954
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0105 0.1566
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0067 0.0119 0.0958
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0105 0.1566
Schistosoma mansoni cpg binding protein 0.029 0.0659 0.0784
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.005 0.0049
Loa Loa (eye worm) transcription factor SMAD2 0.0361 0.0832 0.1999
Leishmania major phosphoglycerate kinase C, glycosomal 0.0169 0.0365 0.1675
Trichomonas vaginalis diacylglycerol kinase, putative 0.0067 0.0119 0.1781
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.01 0.01

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 0 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as growth inhibition at 25 uM after 5 days relative to control ChEMBL. 21506600
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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