Detailed information for compound 1575466

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.822 | Formula: C17H18ClN7O4
  • H donors: 2 H acceptors: 3 LogP: 3.1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc([N+](=O)[O-])c(cc1c1nc2n(c1/C=N/NC(=N)N)cccc2)OC.Cl
  • InChi: 1S/C17H17N7O4.ClH/c1-27-13-8-11(24(25)26)14(28-2)7-10(13)16-12(9-20-22-17(18)19)23-6-4-3-5-15(23)21-16;/h3-9H,1-2H3,(H4,18,19,22);1H/b20-9+;
  • InChiKey: GCSMWXMFNWLJCH-NFLPFLSFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Schistosoma japonicum IPR000719,Protein kinase,domain-containing Get druggable targets OG5_128147 All targets in OG5_128147
Loa Loa (eye worm) AGC/RSK/RSK protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_128147 All targets in OG5_128147
Leishmania donovani rac serine-threonine kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Leishmania infantum rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Leishmania mexicana rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Leishmania braziliensis rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Schistosoma japonicum Ribosomal protein S6 kinase alpha-2, putative Get druggable targets OG5_128147 All targets in OG5_128147
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
Brugia malayi ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
Giardia lamblia Kinase, AGC AKT Get druggable targets OG5_128147 All targets in OG5_128147
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0217 0.0478
Loa Loa (eye worm) hypothetical protein 0.0075 0.0251 0.0554
Loa Loa (eye worm) hypothetical protein 0.0239 0.0936 0.2071
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0186 0.0411
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0073 0.0159
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0029 0.0062
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0029 0.0064
Toxoplasma gondii protease inhibitor PI2 0.0038 0.0096 0.0213
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0335 0.1336 0.2955
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0922 0.2038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.021
Echinococcus granulosus phd:f box containing protein 0.0016 0.0005 0.0006
Echinococcus multilocularis tubulin alpha 0.061 0.2486 0.2486
Schistosoma mansoni hypothetical protein 0.0504 0.2042 0.2402
Leishmania major beta tubulin 0.1097 0.4519 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0026 0.003
Echinococcus multilocularis tubulin beta 1 chain 0.1097 0.4519 0.4519
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0046
Schistosoma mansoni hypothetical protein 0.0504 0.2042 0.2402
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0374
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0019 0.0022
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.007 0.0082
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0073 0.0128
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0149
Schistosoma mansoni rab6-interacting 0.0078 0.0266 0.0313
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0095 0.0207
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.004 0.004
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0029 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0047 0.0103
Trichomonas vaginalis tubulin, putative 0.0335 0.1336 0.2955
Schistosoma mansoni survival motor neuron protein 0.0049 0.0143 0.0168
Brugia malayi TAZ zinc finger family protein 0.0102 0.0363 0.0801
Plasmodium falciparum glutathione reductase 0.0032 0.0073 0.0151
Brugia malayi beta-tubulin, identical 0.1097 0.4519 1
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Leishmania major beta tubulin 0.1097 0.4519 1
Brugia malayi tailless protein 0.0022 0.0029 0.0062
Echinococcus granulosus lipoxygenase domain containing protein 0.0078 0.0266 0.0312
Leishmania major hypothetical protein, conserved 0.0075 0.0252 0.0555
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0059 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0108
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0029 0.0035
Schistosoma mansoni rab6-interacting 0.0078 0.0266 0.0313
Brugia malayi protein kinase C II. 0.0018 0.0015 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0152 0.0336
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0069 0.015
Brugia malayi hypothetical protein 0.0022 0.0029 0.0062
Trypanosoma brucei beta tubulin 0.1097 0.4519 1
Trypanosoma brucei beta tubulin 0.1097 0.4519 1
Loa Loa (eye worm) agrin synaptic family protein 0.0038 0.0096 0.0213
Trypanosoma cruzi tubulin gamma chain 0.0637 0.2598 0.5747
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.004 0.0088
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0548 0.2225 0.4923
Trichomonas vaginalis tubulin, putative 0.1097 0.4519 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0152 0.0179
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0005 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Trichomonas vaginalis tubulin epsilon chain, putative 0.1097 0.4519 1
Loa Loa (eye worm) tubulin alpha 2 0.0548 0.2225 0.4923
Plasmodium falciparum alpha tubulin 1 0.0823 0.3375 0.7465
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0125 0.0147
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0252 0.0546
Trichomonas vaginalis tubulin alpha chain, putative 0.1097 0.4519 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0038 0.0096 0.021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0152 0.0334
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0386 0.0454
Schistosoma mansoni agrin 0.0038 0.0096 0.0113
Brugia malayi Protein kinase domain containing protein 0.0018 0.0015 0.003
Schistosoma mansoni multidrug resistance protein 0.0021 0.0026 0.0031
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.0767 0.0902
Plasmodium falciparum tubulin beta chain 0.1097 0.4519 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0087 0.0189
Echinococcus granulosus Tubulin beta 2C chain 0.1097 0.4519 0.5316
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0374
Toxoplasma gondii thioredoxin reductase 0.0093 0.0326 0.0722
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0018 0.0015 0.0015
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0096 0.0213
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0087 0.0189
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0005 0.0006
Echinococcus multilocularis expressed conserved protein 0.0183 0.0705 0.0705
Brugia malayi ecdysteroid receptor 0.0051 0.0152 0.0334
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0095 0.0207
Schistosoma mansoni lamin 0.0053 0.0162 0.0191
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0003 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0087 0.0189
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0169 0.0372
Loa Loa (eye worm) hypothetical protein 0.0078 0.0266 0.0588
Schistosoma mansoni alpha tubulin 0.0823 0.3375 0.397
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Brugia malayi MH2 domain containing protein 0.0024 0.004 0.0086
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0069 0.015
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0275 0.1089 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0275 0.1089 1
Schistosoma mansoni hypothetical protein 0.0081 0.0276 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0077 0.0168
Schistosoma mansoni cpg binding protein 0.006 0.019 0.0224
Echinococcus granulosus Polycystic kidney disease protein 0.0078 0.0266 0.0312
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0096 0.021
Brugia malayi isocitrate dehydrogenase 0.0031 0.007 0.0152
Schistosoma mansoni lipoxygenase 0.014 0.0525 0.0617
Plasmodium falciparum tubulin delta chain, putative 0.0275 0.1089 0.2401
Echinococcus granulosus tubulin epsilon chain 0.0636 0.2596 0.3054
Schistosoma mansoni tubulin subunit alpha 0.0823 0.3375 0.397
Schistosoma mansoni hypothetical protein 0.0081 0.0276 0.0325
Trypanosoma cruzi alpha tubulin, putative 0.0823 0.3375 0.7467
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.0823 0.752
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0026 0.0055
Leishmania major beta tubulin 0.1097 0.4519 1
Onchocerca volvulus 0.0236 0.0923 0.6854
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.0169 0.0374
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0026 0.003
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0027 0.0056
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0201 0.0236
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0096 0.021
Schistosoma mansoni coup transcription factor 0.0051 0.0152 0.0179
Trichomonas vaginalis tubulin gamma chain, putative 0.0636 0.2596 0.5744
Schistosoma mansoni smad 0.0024 0.004 0.0047
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0119 0.0437 0.0513
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0058 0.0068
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0026 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0152 0.0336
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0152 0.0152
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0026 0.0046
Mycobacterium tuberculosis Probable oxidoreductase 0.0235 0.0921 0.8438
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0186 0.0218
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0152 0.0179
Loa Loa (eye worm) hypothetical protein 0.0485 0.1964 0.4346
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0096 0.021
Giardia lamblia Beta tubulin 0.1097 0.4519 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0026 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0098 0.0213
Brugia malayi Pre-SET motif family protein 0.0207 0.0803 0.1775
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0102 0.0366 0.081
Brugia malayi PAS domain containing protein 0.0145 0.0543 0.1198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0077 0.0168
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0073 0.0159
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0754 0.0754
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0026 0.0026
Brugia malayi hypothetical protein 0.0029 0.0062 0.0134
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0366 0.0807
Plasmodium vivax glutathione reductase, putative 0.0093 0.0326 0.0712
Echinococcus granulosus Smad4 0.0024 0.004 0.0047
Echinococcus granulosus beta tubulin 0.1097 0.4519 0.5316
Echinococcus granulosus protein kinase c epsilon type 0.0018 0.0015 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0152 0.0179
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0055
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0201 0.0236
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0125 0.0124
Schistosoma mansoni jun-related protein 0.0069 0.0227 0.0267
Loa Loa (eye worm) tubulin beta chain 0.0275 0.1089 0.2409
Trypanosoma cruzi tubulin delta chain 0.044 0.1778 0.3932
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Mycobacterium ulcerans cell division protein FtsZ 0.0275 0.1089 1
Echinococcus multilocularis CREB binding protein 0.0017 0.0009 0.0008
Echinococcus multilocularis tubulin alpha 3 chain 0.0823 0.3375 0.3374
Brugia malayi alpha-tubulin 0.0823 0.3375 0.7467
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0102 0.0366 0.0807
Echinococcus multilocularis geminin 0.0504 0.2042 0.2041
Plasmodium falciparum glutathione reductase 0.0093 0.0326 0.0712
Brugia malayi hypothetical protein 0.0022 0.0029 0.0062
Echinococcus granulosus tubulin alpha 1C chain 0.0823 0.3375 0.3969
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0915 0.2022
Echinococcus multilocularis expressed protein 0.0038 0.0096 0.0096
Echinococcus granulosus tubulin subunit beta 0.1097 0.4519 0.5316
Schistosoma mansoni organic anion transporter 0.0055 0.0169 0.0199
Brugia malayi ABC transporter family protein 0.0021 0.0026 0.0055
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0021 0.0051
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.0169 0.0169
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0016 0.0018
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0059 0.0058
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0062 0.0062
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0915 0.2024
Schistosoma mansoni tubulin subunit delta 0.0275 0.1089 0.1281
Echinococcus multilocularis Tubulin beta 2C chain 0.1097 0.4519 0.4519
Trichomonas vaginalis guanylate cyclase, putative 0.0038 0.0096 0.021
Echinococcus granulosus mitogen activated protein kinase 3 0.0102 0.0366 0.043
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0125 0.0273
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Loa Loa (eye worm) AGC/AKT protein kinase 0.0018 0.0015 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0015 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0152 0.0334
Echinococcus granulosus tubulin beta 1 chain 0.1097 0.4519 0.5316
Chlamydia trachomatis endonuclease IV 0.0075 0.0251 1
Echinococcus multilocularis RUN 0.0078 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Brugia malayi nuclear receptor RXR 0.0029 0.0062 0.0134
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0152 0.0179
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0026 0.0055
Brugia malayi Protein kinase domain containing protein 0.0016 0.0005 0.0008
Brugia malayi steroid hormone receptor 0.0051 0.0152 0.0334
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0026 0.0055
Brugia malayi MH2 domain containing protein 0.0355 0.142 0.3141
Loa Loa (eye worm) BEN-1 protein 0.1097 0.4519 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0026 0.0058
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0029 0.0062
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0038 0.0081
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0026 0.0055
Trypanosoma brucei beta tubulin 0.061 0.2486 0.55
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0026 0.0058
Leishmania major beta tubulin 0.1097 0.4519 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0152 0.0336
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0152 0.0179
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0289 0.0289
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0186 0.0219
Leishmania major beta tubulin 0.1097 0.4519 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0101 0.0221
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0095 0.0112
Schistosoma mansoni atypical protein kinase C 0.0018 0.0015 0.0017
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0169 0.1127
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0366 0.0807
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0026 0.0055
Echinococcus granulosus follistatin 0.0038 0.0096 0.0113
Brugia malayi Cytochrome P450 family protein 0.004 0.0108 0.0236
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0094
Trypanosoma brucei cytochrome P450, putative 0.004 0.0108 0.0236
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.007 0.007
Trypanosoma brucei trypanothione reductase 0.0093 0.0326 0.072
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0026 0.003
Echinococcus multilocularis protein patched 0.0084 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0048 0.0138 0.0305
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0073 0.0159
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0548 0.2225 0.4922
Schistosoma mansoni alpha tubulin 0.0823 0.3375 0.397
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0235 0.0921 0.8438
Mycobacterium tuberculosis Probable reductase 0.0212 0.0823 0.752
Schistosoma mansoni intermediate filament proteins 0.0053 0.0162 0.0191
Echinococcus multilocularis Tubulin alpha 1 chain 0.0823 0.3375 0.3374
Trichomonas vaginalis tubulin alpha chain, putative 0.0335 0.1336 0.2955
Schistosoma mansoni hypothetical protein 0.0078 0.0266 0.0313
Brugia malayi Protein kinase domain containing protein 0.0018 0.0015 0.003
Trichomonas vaginalis tubulin alpha chain, putative 0.061 0.2486 0.55
Trypanosoma cruzi beta tubulin, putative 0.1097 0.4519 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0152 0.0152
Brugia malayi MAP kinase sur-1 0.0102 0.0366 0.0807
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0026 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0029 0.0029
Echinococcus multilocularis jun protein 0.0085 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0112
Echinococcus granulosus Tubulin alpha 1 chain 0.0823 0.3375 0.3969
Echinococcus multilocularis tubulin gamma 1 chain 0.0637 0.2598 0.2598
Plasmodium falciparum tubulin epsilon chain, putative 0.0636 0.2596 0.574
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0018 0.0015 0.0032
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0026 0.0055
Plasmodium vivax multidomain scavenger receptor, putative 0.0078 0.0266 0.0577
Trypanosoma brucei zeta tubulin 0.0551 0.224 0.4956
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0018 0.0015 0.0017
Echinococcus granulosus tubulin delta chain 0.0275 0.1089 0.1281
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0073 0.0159
Brugia malayi Tubulin alpha chain 0.0823 0.3375 0.7467
Trichomonas vaginalis abcb9, putative 0.0021 0.0026 0.0055
Plasmodium falciparum alpha tubulin 2 0.0823 0.3375 0.7465
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0026 0.0055
Echinococcus granulosus CREB binding protein 0.0017 0.0009 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0152 0.0334
Echinococcus multilocularis agrin 0.0038 0.0096 0.0096
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0152 0.0152
Echinococcus multilocularis musashi 0.0053 0.0162 0.0162
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0125 0.0273
Schistosoma mansoni DNA helicase recq5 0.0029 0.0059 0.0069
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0073 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0125 0.0273
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0102 0.0366 0.0808
Plasmodium falciparum thioredoxin reductase 0.0032 0.0073 0.0151
Trypanosoma brucei tubulin delta chain 0.044 0.1778 0.3932
Echinococcus multilocularis CREB binding protein 0.007 0.023 0.023
Trichomonas vaginalis tubulin epsilon chain, putative 0.0275 0.1089 0.2407
Schistosoma mansoni lamin 0.0053 0.0162 0.0191
Entamoeba histolytica protein kinase, putative 0.0018 0.0015 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0062 0.0134
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0152 0.0179
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0003 0.0002
Echinococcus multilocularis tubulin delta chain 0.0275 0.1089 0.1089
Toxoplasma gondii alpha-tubulin I, putative 0.0823 0.3375 0.7468
Plasmodium vivax tubulin alpha chain, putative 0.0823 0.3375 0.7465
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0005 0.0006
Schistosoma mansoni tubulin subunit beta 0.1097 0.4519 0.5316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0068 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0064 0.0138
Loa Loa (eye worm) BEN-1 protein 0.1097 0.4519 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.004 0.0047
Echinococcus granulosus intermediate filament protein 0.0053 0.0162 0.0191
Echinococcus granulosus peroxisome assembly protein 26 0.0823 0.3375 0.3969
Echinococcus multilocularis neuropeptide s receptor 0.0919 0.3774 0.3774
Toxoplasma gondii beta tubulin 0.1097 0.4519 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0448 0.0527
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0186 0.0186
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0025 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0096 0.021
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0187 0.0187
Brugia malayi ecdysone receptor 0.0022 0.0029 0.0062
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0005 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0289 0.0637
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0073 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0011
Echinococcus multilocularis beta tubulin 0.1097 0.4519 0.4519
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.142 0.3143
Loa Loa (eye worm) tubulin beta-4 chain 0.1097 0.4519 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.007 0.0507
Brugia malayi Tubulin beta chain 0.0335 0.1336 0.2955
Brugia malayi p70 ribosomal S6 kinase beta 0.0018 0.0015 0.003
Giardia lamblia Kinase, CMGC MAPK 0.0102 0.0366 0.0778
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0029 0.0063
Brugia malayi MH1 domain containing protein 0.0024 0.004 0.0086
Onchocerca volvulus 0.0022 0.0029 0.0063
Echinococcus multilocularis mitogen activated protein kinase 0.0102 0.0366 0.0366
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0252 0.0555
Schistosoma mansoni hypothetical protein 0.0107 0.0386 0.0454
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0125 0.0273
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0251 0.0544
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0187 0.022
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0096 0.0213
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0096 0.021
Onchocerca volvulus 0.0067 0.0217 0.1491
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.004 0.0078
Brugia malayi jmjC domain containing protein 0.0063 0.0201 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0077 0.0168
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0026 0.0055
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0073 0.0159
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0001 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0125 0.0273
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0374
Brugia malayi Isocitrate dehydrogenase 0.0031 0.007 0.0152
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0062 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0152 0.0334
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0152 0.0152
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.007 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0152 0.0336
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0488 0.1977 0.4374
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0187 0.0187
Schistosoma mansoni ap endonuclease 0.0018 0.0016 0.0018
Trichomonas vaginalis tubulin beta chain, putative 0.0823 0.3375 0.7467
Echinococcus granulosus Tubulin beta 2C chain 0.1097 0.4519 0.5316
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0251 0.215
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0026 0.0055
Brugia malayi Thioredoxin reductase 0.0093 0.0326 0.072
Echinococcus granulosus smad 0.0024 0.004 0.0047
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0073 0.0086
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0152 0.0997
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0016 0.0015
Onchocerca volvulus 0.0055 0.0169 0.1127
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0038 0.0096 0.021
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0021 0.0051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.007 0.007
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.007 0.0152
Trypanosoma brucei rac serine-threonine kinase, putative 0.0018 0.0015 0.003
Schistosoma mansoni organic anion transporter 0.0055 0.0169 0.0199
Leishmania major zeta tubulin, putative 0.0551 0.224 0.4956
Schistosoma mansoni multidrug resistance protein 0.0021 0.0026 0.0031
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0029 0.0029
Schistosoma mansoni aryl hydrocarbon receptor 0.0145 0.0543 0.0638
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0073 0.0159
Brugia malayi hypothetical protein 0.0078 0.0266 0.0585
Trypanosoma brucei zeta tubulin, putative 0.0551 0.224 0.4956
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0252 0.0555
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0073 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.0437 0.0514
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0073 0.0539
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0026 0.003
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0029 0.0029
Schistosoma mansoni tubulin subunit beta 0.1097 0.4519 0.5316
Trypanosoma brucei alpha tubulin, putative 0.0335 0.1336 0.2955
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0026 0.0055
Loa Loa (eye worm) hypothetical protein 0.0029 0.0059 0.0129
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0289 0.0639
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.007 0.0082
Echinococcus granulosus CREB binding protein 0.0063 0.0201 0.0236
Leishmania major gamma-tubulin 0.0637 0.2598 0.5747
Entamoeba histolytica protein kinase, putative 0.0018 0.0015 0.0033
Echinococcus granulosus neuropeptide s receptor 0.0919 0.3774 0.444
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0201 0.0443
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0152 0.0179
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0018 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Schistosoma mansoni tubulin subunit beta 0.1097 0.4519 0.5316
Echinococcus granulosus RUN 0.0078 0.0266 0.0312
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.061 0.2486 0.5502
Echinococcus multilocularis Tubulin beta 2C chain 0.1097 0.4519 0.4519
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0016 0.0143
Plasmodium falciparum tubulin gamma chain 0.0637 0.2598 0.5744
Onchocerca volvulus 0.0078 0.0266 0.1861
Giardia lamblia Gamma tubulin 0.0637 0.2598 0.5734
Echinococcus multilocularis serine:threonine protein kinase N2 0.0018 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0152 0.0334
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0096 0.0213
Trypanosoma cruzi epsilon tubulin, putative 0.0636 0.2596 0.5744
Brugia malayi MH1 domain containing protein 0.0024 0.004 0.0086
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0026 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0015 0.0017
Brugia malayi Pre-SET motif family protein 0.0031 0.0068 0.0147
Brugia malayi prostaglandin transporter 0.0055 0.0169 0.0372
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.1104 0.1104
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0026 0.0055
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0073 0.0159
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0017 0.002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.007 0.0154
Trichomonas vaginalis tubulin epsilon chain, putative 0.0823 0.3375 0.7467
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Entamoeba histolytica hypothetical protein 0.0107 0.0386 0.0853
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0125 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0026 0.0057
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0026 0.0026
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.0936 0.1101
Echinococcus multilocularis tubulin alpha chain 0.0823 0.3375 0.3374
Loa Loa (eye worm) hypothetical protein 0.0038 0.0096 0.0213
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0073 0.0159
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0754 0.1667
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Brugia malayi hypothetical protein 0.0485 0.1964 0.4345
Brugia malayi hypothetical protein 0.0107 0.0386 0.085
Schistosoma mansoni smad1 5 8 and 0.0024 0.004 0.0047
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Echinococcus multilocularis peroxisome assembly protein 26 0.0823 0.3375 0.3374
Brugia malayi CXXC zinc finger family protein 0.0057 0.0177 0.0389
Schistosoma mansoni nuclear receptor 0.0022 0.0029 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0275 0.1089 0.2407
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.1104 0.1298
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0096 0.021
Echinococcus multilocularis cpg binding protein 0.006 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0336
Echinococcus granulosus jun protein 0.0085 0.0293 0.0345
Schistosoma mansoni cellular tumor antigen P53 0.0148 0.0559 0.0657
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0032
Entamoeba histolytica protein kinase, putative 0.0018 0.0015 0.0033
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0402 0.0889
Loa Loa (eye worm) CYP4Cod1 0.004 0.0108 0.0238
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0374
Schistosoma mansoni hypothetical protein 0.0811 0.3326 0.3912
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0386 0.0453
Loa Loa (eye worm) alpha-tubulin 0.0823 0.3375 0.7468
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0217 0.0255
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0073 0.0539
Mycobacterium ulcerans hypothetical protein 0.002 0.0021 0.0051
Brugia malayi nuclear receptor NHR-67 0.0022 0.0029 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0073 0.0159
Giardia lamblia Beta tubulin 0.1097 0.4519 1
Onchocerca volvulus 0.0049 0.0143 0.0923
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0029 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0152 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0152 0.0336
Leishmania major protein kinase, putative 0.0039 0.0101 0.0221
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0011
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0102 0.0366 0.0808
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0152 0.0179
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0087 0.0189
Schistosoma mansoni tubulin subunit alpha 0.0823 0.3375 0.397
Schistosoma mansoni multidrug resistance protein 0.0021 0.0026 0.0031
Echinococcus granulosus beta tubulin 0.1097 0.4519 0.5316
Brugia malayi hypothetical protein 0.0029 0.0062 0.0134
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0095 0.0111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0062 0.0073
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0152 0.0179
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0217 0.0478
Echinococcus multilocularis tubulin alpha chain 0.0823 0.3375 0.3374
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0281 0.1113 0.1309
Onchocerca volvulus 0.0055 0.0169 0.1127
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0073 0.0151
Brugia malayi secreted modular calcium-binding protein 1 0.0038 0.0096 0.021
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Leishmania major cytochrome p450-like protein 0.004 0.0108 0.0236
Leishmania major beta tubulin 0.1097 0.4519 1
Echinococcus granulosus tubulin beta 4A class IVa 0.1097 0.4519 0.5316
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0374
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.007 0.007
Echinococcus multilocularis aryl hydrocarbon receptor 0.0038 0.0096 0.0096
Onchocerca volvulus 0.0051 0.0152 0.0997
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0029 0.0035
Loa Loa (eye worm) AGC/PKN protein kinase 0.0018 0.0015 0.0032
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0073 0.2102
Trichomonas vaginalis tubulin gamma chain, putative 0.0637 0.2598 0.5747
Schistosoma mansoni microtubule-associated protein tau 0.2051 0.8501 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0073 0.0086
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0095 0.021
Echinococcus multilocularis tubulin alpha 3 chain 0.0823 0.3375 0.3374
Trypanosoma cruzi zeta tubulin, putative 0.0551 0.224 0.4956
Plasmodium falciparum thioredoxin reductase 0.0093 0.0326 0.0712
Leishmania major trypanothione reductase 0.0093 0.0326 0.072
Brugia malayi Tubulin alpha-2 chain 0.0823 0.3375 0.7467
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.025 0.0293
Brugia malayi bHLH-PAS transcription factor 0.0107 0.0386 0.0851
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0119 0.0437 0.0436
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0152 0.0179
Brugia malayi multidrug resistance protein 3 0.0021 0.0026 0.0055
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0162 0.0359
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0119 0.0437 0.0965
Echinococcus multilocularis Tubulin alpha 1 chain 0.0823 0.3375 0.3374
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0125 0.0275
Echinococcus multilocularis Tubulin beta 2C chain 0.1097 0.4519 0.4519
Brugia malayi Tubulin gamma chain 0.0637 0.2598 0.5747
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0068 0.0067
Trichomonas vaginalis tubulin alpha chain, putative 0.0335 0.1336 0.2955
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0326 0.072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0084
Echinococcus granulosus serine:threonine protein kinase N2 0.0018 0.0015 0.0017
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.007 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0068 0.008
Trypanosoma cruzi epsilon tubulin, putative 0.0636 0.2596 0.5744
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.0169 0.0169
Echinococcus multilocularis follistatin 0.0038 0.0096 0.0096
Echinococcus granulosus lipoxygenase domain containing protein 0.0078 0.0266 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0084
Echinococcus granulosus alpha tubulin 0.0823 0.3375 0.3969
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0018 0.0015 0.0032
Plasmodium vivax tubulin gamma chain, putative 0.0637 0.2598 0.5744
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.0823 0.752
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0109 0.0239
Brugia malayi Cell division protein ftsZ 0.0275 0.1089 0.2407
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0059 0.0129
Echinococcus granulosus CREB binding protein 0.0017 0.0009 0.001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.007 0.0152
Brugia malayi CHE-14 protein 0.0084 0.0289 0.0637
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0062 0.0134
Echinococcus multilocularis tubulin epsilon chain 0.0636 0.2596 0.2596
Plasmodium vivax tubulin epsilon chain, putative 0.0636 0.2596 0.574
Schistosoma mansoni smdr2 0.0021 0.0026 0.0031
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0073 0.0159
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0026 0.0026
Toxoplasma gondii alpha tubulin TUBA1 0.0823 0.3375 0.7468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0084
Leishmania major beta tubulin 0.1097 0.4519 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0057
Trichomonas vaginalis tubulin beta chain, putative 0.1097 0.4519 1
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.0169 0.0199
Schistosoma mansoni tubulin subunit epsilon 0.0636 0.2596 0.3054
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.0823 0.752
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.0169 0.0375
Echinococcus multilocularis tumor protein p63 0.1014 0.4172 0.4172
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0152 0.0334
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0005 0.0006
Mycobacterium leprae Possible regulatory protein 0.0038 0.0096 0.0702
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0073 0.0151
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0186 0.0408
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0009
Echinococcus granulosus microtubule associated protein 2 0.2051 0.8501 1
Leishmania major beta tubulin 0.1097 0.4519 1
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0016 0.0033
Loa Loa (eye worm) doublecortin family protein 0.0078 0.0266 0.0588
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0068 0.008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0073 0.0539
Echinococcus granulosus tubulin alpha chain 0.0823 0.3375 0.3969
Brugia malayi Smad1 0.0024 0.004 0.0086
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0005 0.0012
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0077 0.0168
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0374
Echinococcus multilocularis neuropeptide receptor A26 0.0919 0.3774 0.3774
Brugia malayi nuclear receptor RXR 0.0022 0.0029 0.0062
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.0823 0.752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0049 0.0105
Loa Loa (eye worm) hypothetical protein 0.0488 0.1977 0.4375
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0026 0.0026
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0125 0.0273
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0026 0.0058
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0062 0.0073
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.007 0.0155
Schistosoma mansoni DNA helicase recq1 0.0029 0.0059 0.0069
Echinococcus granulosus tubulin alpha chain 0.0823 0.3375 0.3969
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0029 0.0064
Echinococcus granulosus tubulin subunit TubB 0.0823 0.3375 0.3969
Echinococcus multilocularis smad 0.0024 0.004 0.004
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0101 0.0221
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0125 0.0273
Trichomonas vaginalis tubulin, putative 0.0302 0.12 0.2654
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0823 0.3375 0.7467
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0026 0.0058
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0073 0.0539
Echinococcus granulosus tubulin alpha chain 0.0823 0.3375 0.3969
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0152 0.0152
Echinococcus granulosus tubulin alpha chain 0.0823 0.3375 0.3969
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0047 0.0047
Brugia malayi hypothetical protein 0.0078 0.0266 0.0585
Schistosoma mansoni ap endonuclease 0.0018 0.0016 0.0018
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0059 0.0129
Loa Loa (eye worm) hypothetical protein 0.0148 0.0559 0.1236
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0016 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0016 0.0031
Echinococcus granulosus tubulin alpha 3 chain 0.0823 0.3375 0.3969
Echinococcus multilocularis serine threonine protein kinase 0.0018 0.0015 0.0015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0152 0.0336
Echinococcus granulosus geminin 0.0504 0.2042 0.2401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0068 0.008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0073 0.0159
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0017 0.0038
Entamoeba histolytica tubulin alpha-1 chain 0.0823 0.3375 0.7468
Echinococcus granulosus NDR protein kinase 0.0018 0.0015 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0152 0.0336
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0162 0.0357
Leishmania major delta tubulin, putative 0.044 0.1778 0.3932
Onchocerca volvulus 0.0038 0.0096 0.0572
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0059 0.0058
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0038 0.0096 0.0212
Echinococcus multilocularis lamin 0.0053 0.0162 0.0162
Leishmania major beta tubulin 0.1097 0.4519 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0026 0.0055
Loa Loa (eye worm) hypothetical protein 0.0124 0.0456 0.1008
Schistosoma mansoni tubulin subunit alpha 0.0275 0.1089 0.1281
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0152 0.0179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0073 0.0159
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0102 0.0366 0.0809
Echinococcus granulosus Tubulin beta 2C chain 0.1097 0.4519 0.5316
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0152 0.0334
Schistosoma mansoni cpg binding protein 0.006 0.019 0.0224
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0016 0.0034
Brugia malayi Protein kinase domain containing protein 0.0018 0.0015 0.003
Loa Loa (eye worm) tubulin beta-2A chain 0.1097 0.4519 1
Echinococcus multilocularis CREB binding protein 0.0017 0.0009 0.0008
Trichomonas vaginalis tubulin gamma chain, putative 0.0275 0.1089 0.2407
Trypanosoma brucei protein kinase, putative 0.0102 0.0366 0.0807
Schistosoma mansoni patched 1 0.0084 0.0289 0.034
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0016 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0029 0.0034
Leishmania major p-glycoprotein 0.0021 0.0026 0.0055
Brugia malayi nuclear receptor NHR-88 0.0022 0.0029 0.0062
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0068 0.015
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0217 0.0256
Trichomonas vaginalis tubulin epsilon chain, putative 0.0823 0.3375 0.7467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0015 0.0017
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0096 0.021
Echinococcus multilocularis mitogen activated protein kinase 3 0.0102 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0075 0.0252 0.0557
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0125 0.0273
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0026 0.0046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0136
Echinococcus multilocularis protein dispatched 1 0.0096 0.0338 0.0338
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0102 0.0366 0.0807
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0026 0.0058
Plasmodium vivax tubulin alpha chain, putative 0.0823 0.3375 0.7465
Loa Loa (eye worm) tubulin alpha chain 0.0823 0.3375 0.7468
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0152 0.0997
Leishmania major beta tubulin 0.1097 0.4519 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0217 0.0217
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0217 0.0478
Schistosoma mansoni Smad4 0.0024 0.004 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0152 0.0179
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0108 0.0236
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0152 0.0152
Echinococcus granulosus CREB binding protein 0.0102 0.0363 0.0427
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0073 0.0539
Loa Loa (eye worm) Smad1 0.0024 0.004 0.0088
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0026 0.003
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0251 0.219
Schistosoma mansoni hypothetical protein 0.0034 0.0079 0.0093
Echinococcus granulosus tumor protein p63 0.1014 0.4172 0.4907
Echinococcus granulosus protein kinase C gamma type 0.0018 0.0015 0.0017
Schistosoma mansoni single-minded 0.0145 0.0543 0.0638
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0068 0.0079
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0109 0.0239
Leishmania major beta tubulin 0.1097 0.4519 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0084
Toxoplasma gondii tubulin, putative 0.0026 0.0049 0.0109
Schistosoma mansoni alpha tubulin 0.0823 0.3375 0.397
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1097 0.4519 0.4519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0084
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0026 0.0055
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0005 0.0006
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0019 0.0019
Trypanosoma cruzi tubulin delta chain 0.044 0.1778 0.3932
Schistosoma mansoni CREB-binding protein 2 0.0102 0.0363 0.0427
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0201 0.0236
Brugia malayi bZIP transcription factor family protein 0.0085 0.0293 0.0646
Trichomonas vaginalis tubulin, putative 0.0335 0.1336 0.2955
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0152 0.0179
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0548 0.2225 0.4923
Leishmania major beta tubulin 0.1097 0.4519 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0073 0.0159
Loa Loa (eye worm) pax transcription factor protein 2 0.0243 0.0954 0.211
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0293 0.0293
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0026 0.003
Echinococcus multilocularis Tubulin beta 2C chain 0.1097 0.4519 0.4519
Onchocerca volvulus 0.0055 0.0169 0.1127
Brugia malayi glutathione reductase 0.0093 0.0326 0.072
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0059 0.0095
Echinococcus granulosus expressed conserved protein 0.0183 0.0705 0.0829
Onchocerca volvulus 0.0078 0.0266 0.1861
Echinococcus granulosus tubulin alpha 0.061 0.2486 0.2924
Brugia malayi conserved hypotetical protein 0.0022 0.0029 0.0062
Trichomonas vaginalis guanylate cyclase, putative 0.0038 0.0096 0.021
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0005 0.0005
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0217 0.0481
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0005 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0366 0.0807
Schistosoma mansoni loxhd1 0.0078 0.0266 0.0313
Giardia lamblia Alpha-tubulin 0.0823 0.3375 0.7459
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0108 0.086
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0069 0.015
Entamoeba histolytica tubulin alpha chain, putative 0.0823 0.3375 0.7468
Echinococcus multilocularis CREB binding protein 0.0017 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0156 0.0589 0.0693
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0152 0.0334
Echinococcus granulosus agrin 0.0038 0.0096 0.0113
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0108 0.0236
Brugia malayi jmjC domain containing protein 0.0059 0.0187 0.0411
Leishmania major beta tubulin 0.1097 0.4519 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0026 0.0055
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0096 0.021
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0099 0.0207
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0026 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0143 0.0312
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0326 0.0712
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Loa Loa (eye worm) hypothetical protein 0.0053 0.0158 0.035
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0095 0.0207
Trichomonas vaginalis adenylate cyclase, putative 0.0038 0.0096 0.021
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0275 0.1089 0.2407
Trichomonas vaginalis conserved hypothetical protein 0.0275 0.1089 0.2407
Plasmodium vivax delta tubulin, putative 0.0275 0.1089 0.2401
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0016 0.0031
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0073 0.0162
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Trichomonas vaginalis tubulin beta chain, putative 0.0335 0.1336 0.2955
Leishmania major epsilon tubulin, putative 0.0636 0.2596 0.5744
Brugia malayi Pax transcription factor protein 2 0.0243 0.0954 0.2108
Brugia malayi Tubulin beta-1 chain 0.1097 0.4519 1
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0152 0.0179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0152 0.0179
Schistosoma mansoni polycystin 1-related 0.0078 0.0266 0.0313
Trypanosoma brucei alpha tubulin 0.0823 0.3375 0.7467
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0803 0.1777
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0026 0.0055
Schistosoma mansoni hypothetical protein 0.0081 0.0276 0.0325
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0152 0.0179
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0025 0.0025
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0009
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0102 0.0366 0.0807
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0366 0.0807
Toxoplasma gondii AGC kinase 0.0018 0.0015 0.0033
Schistosoma mansoni smad1 5 8 and 0.0024 0.004 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0096 0.021
Onchocerca volvulus 0.0022 0.0029 0.0063
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0073 0.0159
Brugia malayi tubulin alpha-2 chain 0.0823 0.3375 0.7467
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0152 0.0179
Onchocerca volvulus 0.0021 0.0026 0.0039
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0073 0.0159
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0059 0.0126
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0009
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0169 0.1127
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0001 0.0002
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0109 0.0109
Onchocerca volvulus Huntingtin homolog 0.0124 0.0456 0.3304
Echinococcus granulosus tubulin alpha 3 chain 0.0823 0.3375 0.3969
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.142 0.3143
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0038 0.0081
Loa Loa (eye worm) DR-78 0.0022 0.0029 0.0064
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0026 0.0055
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0018 0.0015 0.0017
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0095 0.0095
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0029 0.0029
Brugia malayi Cytochrome P450 family protein 0.004 0.0108 0.0236
Brugia malayi Tubulin beta chain 0.0275 0.1089 0.2407
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0095 0.0207
Loa Loa (eye worm) hypothetical protein 0.0038 0.0096 0.0213
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0018 0.0015 0.0015
Toxoplasma gondii beta-tubulin, putative 0.1097 0.4519 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0029 0.0062
Loa Loa (eye worm) alpha-tubulin 0.0823 0.3375 0.7468
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0754 0.1669
Brugia malayi Doublecortin family protein 0.0078 0.0266 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0108
Loa Loa (eye worm) hypothetical protein 0.0103 0.0368 0.0813
Loa Loa (eye worm) tubulin alpha 2 0.0213 0.0828 0.1831
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.004 0.0047
Loa Loa (eye worm) tubulin beta chain 0.1097 0.4519 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.007 0.007
Trypanosoma brucei beta tubulin 0.1097 0.4519 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0059 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Leishmania major protein kinase, putative 0.0039 0.0101 0.0221
Giardia lamblia Delta tubulin 0.0275 0.1089 0.2383
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0252 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0152 0.0334
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0021 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0016 0.0031
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0026 0.0055
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0016 0.0031
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.004 0.0047
Echinococcus granulosus Tubulin beta 2C chain 0.1097 0.4519 0.5316
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0108 0.0238
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0078 0.0266 0.0588
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0077 0.0171
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0336
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0047 0.0055
Loa Loa (eye worm) tubulin alpha chain 0.0823 0.3375 0.7468
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0136
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0059 0.0129
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.0374
Giardia lamblia Kinase, AGC AKT 0.0102 0.0366 0.0779
Trichomonas vaginalis taga, putative 0.0021 0.0026 0.0055
Echinococcus multilocularis beta tubulin 0.1097 0.4519 0.4519
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0011
Echinococcus multilocularis Tubulin beta 2C chain 0.1097 0.4519 0.4519
Echinococcus granulosus tubulin gamma 1 chain 0.0637 0.2598 0.3056
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0186 0.1587
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0152 0.0334
Echinococcus multilocularis lamin dm0 0.0053 0.0162 0.0162
Loa Loa (eye worm) tubulin beta-1 chain 0.1097 0.4519 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.0754 0.1669
Loa Loa (eye worm) hypothetical protein 0.0124 0.0456 0.1008
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0073 0.0151
Brugia malayi intermediate filament protein 0.0053 0.0162 0.0357
Schistosoma mansoni serine/threonine kinase 0.0018 0.0015 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0152 0.0334
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0087 0.0189
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0217 0.0478
Brugia malayi hypothetical protein 0.0055 0.0169 0.0372
Onchocerca volvulus 0.0335 0.1336 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0026 0.0055
Plasmodium vivax SET domain protein, putative 0.0031 0.0068 0.0138
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0102 0.0363 0.0427
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0079 0.0079
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0029 0.0064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0073 0.0159
Schistosoma mansoni lipoxygenase 0.0281 0.1113 0.1309
Onchocerca volvulus 0.0055 0.0169 0.1127
Onchocerca volvulus 0.0031 0.0068 0.0354
Trichomonas vaginalis tubulin beta chain, putative 0.0823 0.3375 0.7467
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0095 0.0176
Trypanosoma brucei alpha tubulin 0.0823 0.3375 0.7467
Onchocerca volvulus 0.0053 0.0162 0.1075
Echinococcus multilocularis tubulin alpha chain 0.0823 0.3375 0.3374
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0101 0.0221
Loa Loa (eye worm) hypothetical protein 0.0084 0.0289 0.0639
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0018 0.0015 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0152 0.0334
Brugia malayi hypothetical protein 0.0239 0.0936 0.2069
Trichomonas vaginalis tubulin beta chain, putative 0.0823 0.3375 0.7467
Giardia lamblia Epsilon tubulin 0.0302 0.1199 0.2627
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0095 0.0111
Echinococcus granulosus lamin dm0 0.0053 0.0162 0.0191
Trypanosoma brucei beta tubulin 0.1097 0.4519 1
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0289 0.034
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0252 0.0555
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0016 0.0031
Echinococcus multilocularis protein kinase c epsilon type 0.0018 0.0015 0.0015
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0029 0.0034
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0073 0.0073
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.007 0.0152
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0029 0.0029
Loa Loa (eye worm) beta-tubulin 0.1097 0.4519 1
Trypanosoma brucei epsilon tubulin 0.0636 0.2596 0.5744
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0038 0.0096 0.0113
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0326 0.0722
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0152 0.0336
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0095 0.0095
Leishmania major beta tubulin 0.1097 0.4519 1
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0059 0.0068
Echinococcus multilocularis Polycystic kidney disease protein 0.0078 0.0266 0.0266
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0217 0.0478
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0029 0.0034
Brugia malayi Hr1 repeat family protein 0.0018 0.0015 0.003
Schistosoma mansoni nuclear receptor 0.0022 0.0029 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0366 0.043
Onchocerca volvulus 0.0107 0.0386 0.2773
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0169 0.1127
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0152 0.0334
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0136
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0079 0.0093
Loa Loa (eye worm) RecQ helicase 0.0041 0.0109 0.0242
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0026 0.0099
Echinococcus granulosus Tubulin beta 2C chain 0.1097 0.4519 0.5316
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0059 0.0118
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0754 0.0887
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0235 0.0921 0.843
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0062 0.0073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0096 0.0212
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0108 0.0238
Trypanosoma brucei epsilon tubulin 0.061 0.2486 0.55
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0281 0.1113 0.1112
Treponema pallidum NADH oxidase 0.0032 0.0073 0.0674
Echinococcus multilocularis tubulin subunit beta 0.1097 0.4519 0.4519
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.0326 0.0384
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0336
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0096 0.0213
Schistosoma mansoni hypothetical protein 0.0049 0.0143 0.0168
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0251 0.0552
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Trichomonas vaginalis tubulin epsilon chain, putative 0.1097 0.4519 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0162 0.0359
Echinococcus granulosus bloom syndrome protein 0.0041 0.0109 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0087 0.0189
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0125 0.0276
Giardia lamblia Alpha-tubulin 0.0823 0.3375 0.7459
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0087 0.0189
Loa Loa (eye worm) tubulin alpha-2 chain 0.0823 0.3375 0.7468
Echinococcus granulosus Protein kinase C brain isozyme 0.0018 0.0015 0.0017
Echinococcus multilocularis Tubulin alpha 1 chain 0.0823 0.3375 0.3374
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0003 0.0002
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0026 0.0055
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0082 0.0283 0.0627
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.025 0.0249
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0017 0.0009 0.0018
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0026 0.0058
Echinococcus multilocularis protein kinase c iota type 0.0018 0.0015 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0152 0.0179
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0366 0.0807
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0015 0.0017
Echinococcus granulosus lamin 0.0053 0.0162 0.0191
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0029 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.006 0.0129
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0186 0.0219
Plasmodium vivax tubulin beta chain, putative 0.1097 0.4519 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0049 0.0057
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0109 0.0239
Entamoeba histolytica hypothetical protein 0.0107 0.0386 0.0853
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0029 0.0062
Trichomonas vaginalis abcb9, putative 0.0021 0.0026 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0152 0.0334
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0101 0.0221
Loa Loa (eye worm) tubulin gamma chain 0.0637 0.2598 0.5748
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0073 0.0159
Loa Loa (eye worm) tubulin alpha 2 0.0548 0.2225 0.4923
Trichomonas vaginalis tubulin beta chain, putative 0.0823 0.3375 0.7467
Trypanosoma brucei epsilon tubulin 0.0636 0.2596 0.5744
Echinococcus granulosus protein kinase c iota type 0.0018 0.0015 0.0017
Schistosoma mansoni hypothetical protein 0.0081 0.0276 0.0325
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0016 0.0034
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.0169 0.0199
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0235 0.0921 0.8438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0077 0.0168
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.0936 0.0936
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.007 0.0152
Trypanosoma cruzi zeta tubulin, putative 0.0551 0.224 0.4956
Schistosoma mansoni tubulin subunit alpha 0.0823 0.3375 0.397
Trypanosoma brucei alpha tubulin 0.0823 0.3375 0.7467
Loa Loa (eye worm) hypothetical protein 0.0823 0.3375 0.7468
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0336
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0015 0.003
Echinococcus granulosus Tubulin alpha 1 chain 0.0823 0.3375 0.3969
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0073 0.0159
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0029 0.0029
Entamoeba histolytica tubulin family protein 0.1097 0.4519 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0096 0.021
Trypanosoma brucei alpha tubulin 0.0823 0.3375 0.7467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0077 0.0168
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0069 0.0153
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Echinococcus granulosus cpg binding protein 0.006 0.019 0.0224
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0016 0.0031
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0169 0.0372
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0069 0.015
Entamoeba histolytica hypothetical protein 0.0107 0.0386 0.0853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0084
Onchocerca volvulus 0.0038 0.0096 0.057
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0096 0.021
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0289 0.034
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0017 0.0017
Brugia malayi Tubulin alpha chain 0.0275 0.1089 0.2407
Echinococcus multilocularis Smad4 0.0024 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0049 0.0105
Schistosoma mansoni zinc finger protein 0.0022 0.0029 0.0035
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0029 0.0035
Loa Loa (eye worm) glutathione reductase 0.0093 0.0326 0.0722
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0251 0.0544
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0336
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0162 0.0359
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0026 0.0058
Echinococcus granulosus transcription factor Dp 1 0.0039 0.01 0.0118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0136
Trichomonas vaginalis abcb9, putative 0.0021 0.0026 0.0055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0186 0.1587
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0152 0.0152
Leishmania major beta tubulin 0.1097 0.4519 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0488 0.1977 0.4375
Echinococcus multilocularis tubulin alpha 1C chain 0.0823 0.3375 0.3374
Onchocerca volvulus 0.0053 0.0162 0.1075
Schistosoma mansoni tubulin subunit beta 0.1097 0.4519 0.5316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0077 0.0168
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0366 0.0807
Mycobacterium ulcerans epimerase 0.002 0.0021 0.0051
Brugia malayi SPARC precursor 0.0038 0.0096 0.021
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0102 0.0366 0.0807
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.007 0.0143
Loa Loa (eye worm) AGC/NDR protein kinase 0.0018 0.0015 0.0032
Schistosoma mansoni tubulin subunit beta 0.0275 0.1089 0.1281
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0009
Mycobacterium leprae cell division protein FtsZ 0.0275 0.1089 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0026 0.0055
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0125 0.0146
Brugia malayi hypothetical protein 0.0055 0.0169 0.0372
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0026 0.0055
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0177 0.0391
Loa Loa (eye worm) hypothetical protein 0.0038 0.0096 0.0213
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0026 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0252 0.0546
Brugia malayi hypoxia-induced factor 1 0.0447 0.1807 0.3997
Echinococcus granulosus single minded 2 0.0107 0.0386 0.0454
Brugia malayi hypothetical protein 0.0067 0.0217 0.0478
Treponema pallidum cell division protein FtsZ 0.0275 0.1089 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0386 0.0385
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0026 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0095 0.0207
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0336
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0026 0.0058
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.007 0.0155
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0096 0.021
Onchocerca volvulus Huntingtin homolog 0.0124 0.0456 0.3304
Loa Loa (eye worm) CBP-B 0.0071 0.0234 0.0516
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0302 0.1199 0.2653
Schistosoma mansoni hypothetical protein 0.0069 0.0227 0.0267
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0125 0.0273
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0102 0.0366 0.0807
Brugia malayi nuclear hormone receptor 0.0051 0.0152 0.0334
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0095 0.0111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0152 0.0179
Echinococcus multilocularis hypothetical protein 0.0823 0.3375 0.3374
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0152 0.0334
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0026 0.0055
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0096 0.021
Giardia lamblia Beta tubulin 0.1097 0.4519 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0152 0.0997
Echinococcus multilocularis tubulin alpha 1C chain 0.0823 0.3375 0.3374
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0015 0.0017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0326 0.2897
Brugia malayi tubulin alpha chain - mouse 0.0823 0.3375 0.7467
Entamoeba histolytica tubulin family protein 0.1097 0.4519 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0009
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.0823 0.7507
Mycobacterium ulcerans endonuclease IV 0.0075 0.0251 0.219
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0095 0.0207
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0038 0.0096 0.0096
Brugia malayi nuclear receptor NHR-88 0.0051 0.0152 0.0334
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0026 0.0055
Echinococcus multilocularis lipoxygenase domain containing protein 0.0078 0.0266 0.0266
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0038 0.0084
Brugia malayi nuclear hormone receptor 0.0022 0.0029 0.0062
Entamoeba histolytica tubulin gamma chain 0.0637 0.2598 0.5749
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0003 0.0003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0095 0.0207
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0059 0.0126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0187 0.022
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0169 0.0372
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0011
Toxoplasma gondii endonuclease IV APN 0.0075 0.0251 0.0555
Onchocerca volvulus 0.0055 0.0169 0.1127
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0186 0.1587
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0064
Echinococcus granulosus tubulin alpha 1C chain 0.0823 0.3375 0.3969
Echinococcus granulosus mitogen activated protein kinase 0.0102 0.0366 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0096 0.0213
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0095 0.0112
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0038 0.0096 0.3111
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0059 0.0129
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0016 0.0033
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.004 0.0047
Schistosoma mansoni tubulin subunit gamma 0.0637 0.2598 0.3056
Giardia lamblia GTOR 0.0044 0.0125 0.0242
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0005 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0125 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0087 0.0189
Trypanosoma cruzi MFS transporter, putative 0.0055 0.0169 0.0372
Schistosoma mansoni follistatin 0.0038 0.0096 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0015 0.0017
Trichomonas vaginalis tubulin alpha chain, putative 0.0335 0.1336 0.2955
Schistosoma mansoni tubulin subunit beta 0.1097 0.4519 0.5316
Onchocerca volvulus 0.0057 0.0177 0.1185
Echinococcus multilocularis transfer RNA-Lys 0.0107 0.0386 0.0386
Echinococcus multilocularis serine:threonine protein kinase 38 0.0018 0.0015 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.0326 0.0326
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.0823 0.752
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0107 0.0386 0.0853
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0068 0.0067
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0095 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0084
Leishmania major beta tubulin 0.1097 0.4519 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0029 0.0035
Echinococcus multilocularis tubulin alpha chain 0.0823 0.3375 0.3374
Leishmania major beta tubulin 0.1097 0.4519 1
Brugia malayi MH2 domain containing protein 0.0024 0.004 0.0086
Schistosoma mansoni tubulin subunit beta 0.1097 0.4519 0.5316
Echinococcus multilocularis dnaJ subfamily B 0.0811 0.3326 0.3325
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0095 0.0095
Brugia malayi hypothetical protein 0.0075 0.0252 0.0555
Toxoplasma gondii beta-1 tubulin, putative 0.1097 0.4519 1
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0096 0.0213
Loa Loa (eye worm) hypoxia-induced factor 1 0.0447 0.1807 0.3999
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0018 0.0015 0.0032
Brugia malayi hypothetical protein 0.0048 0.0141 0.0309
Echinococcus granulosus Tubulin alpha 1 chain 0.0823 0.3375 0.3969
Brugia malayi hypothetical protein 0.0124 0.0456 0.1006
Onchocerca volvulus 0.0148 0.0559 0.4087
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0336
Echinococcus multilocularis lipoxygenase domain containing protein 0.0078 0.0266 0.0266
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0152 0.0179
Echinococcus multilocularis microtubule associated protein 2 0.2051 0.8501 0.8501
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0005 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0029 0.0034
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0029 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0057
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0011
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0217 0.0481
Mycobacterium ulcerans putative regulatory protein 0.0107 0.0386 0.345
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.01 0.01
Trichomonas vaginalis tubulin gamma chain, putative 0.1097 0.4519 1
Brugia malayi Tubulin alpha-2 chain 0.0823 0.3375 0.7467
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0029 0.0034
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0026 0.0026
Echinococcus granulosus tubulin alpha chain 0.0823 0.3375 0.3969
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0005 0.0006
Trichomonas vaginalis tubulin beta chain, putative 0.0823 0.3375 0.7467
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0009
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0186 0.1587
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0252 0.0546
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0029 0.0063
Echinococcus multilocularis tubulin subunit TubB 0.0823 0.3375 0.3374
Echinococcus multilocularis serine:threonine protein kinase N2 0.0018 0.0015 0.0015
Trichomonas vaginalis tubulin beta chain, putative 0.0823 0.3375 0.7467
Onchocerca volvulus 0.0243 0.0954 0.7091
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0152 0.0179
Toxoplasma gondii exonuclease III APE 0.0018 0.0016 0.0034
Echinococcus multilocularis tubulin alpha chain 0.0823 0.3375 0.3374
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.044 0.1778 0.3934
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0026 0.0055
Schistosoma mansoni cpg binding protein 0.0057 0.0177 0.0208
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0073 0.0159
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0003 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.004 0.0088
Trypanosoma brucei tubulin gamma chain 0.0637 0.2598 0.5747
Plasmodium falciparum LCCL domain-containing protein 0.0078 0.0266 0.0577
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0336
Echinococcus granulosus neuropeptide receptor A26 0.0919 0.3774 0.444
Entamoeba histolytica protein kinase, putative 0.0018 0.0015 0.0033
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0293 0.0345
Leishmania major alpha tubulin 0.0823 0.3375 0.7467
Leishmania major beta tubulin 0.1097 0.4519 1
Echinococcus granulosus dnaJ subfamily B 0.0811 0.3326 0.3912
Echinococcus granulosus aryl hydrocarbon receptor 0.0038 0.0096 0.0113
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0073 0.0151

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.8 uM Inhibition of RSK2 assessed as inhibition of substrate phosphorylation using fluorescent peptide substrate by microplate reader assay ChEMBL. 21794960
IC50 (binding) > 100 uM Inhibition of CHK1 assessed as inhibition of substrate phosphorylation using fluorescent peptide substrate by microplate reader assay ChEMBL. 21794960
IC50 (binding) > 100 uM Inhibition of CHK2 assessed as inhibition of substrate phosphorylation using fluorescent peptide substrate by microplate reader assay ChEMBL. 21794960
Inhibition (binding) Inhibition of Aurora kinase A assessed as inhibition of substrate phosphorylation using fluorescent peptide substrate up to 100 uM by microplate reader assay ChEMBL. 21794960

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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