Detailed information for compound 1743921

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1393.66 | Formula: C64H100N18O15S
  • H donors: 15 H acceptors: 15 LogP: -3.19 Rotable bonds: 52
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCS(=O)(=O)C)CC(C)C)C)Cc1ccccc1)Cc1ccccc1)CCC(=O)N)CCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N
  • InChi: 1S/C64H100N18O15S/c1-37(2)34-46(58(90)74-42(53(69)85)28-33-98(4,96)97)78-54(86)38(3)73-57(89)47(35-39-16-7-5-8-17-39)80-59(91)48(36-40-18-9-6-10-19-40)79-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-60(92)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-61(93)49-22-14-31-81(49)62(94)41(66)20-13-30-72-64(70)71/h5-10,16-19,37-38,41-50H,11-15,20-36,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,85)(H,73,89)(H,74,90)(H,75,87)(H,76,92)(H,77,93)(H,78,86)(H,79,88)(H,80,91)(H4,70,71,72)/t38-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1
  • InChiKey: VRAGPHDTXRPMRS-MBIHMLSFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Neurokinin 1 receptor Starlite/ChEMBL References
Homo sapiens tachykinin receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus thyrotropin releasing hormone receptor Neurokinin 1 receptor   407 aa 341 aa 22.9 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Neurokinin 1 receptor   407 aa 339 aa 20.6 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Neurokinin 1 receptor   407 aa 341 aa 26.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Neurokinin 1 receptor   407 aa 373 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Chromobox protein 3 0.0035 0.0021 0.0019
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0073 0.0072
Echinococcus granulosus histone acetyltransferase KAT2B 0.0277 0.0305 0.0303
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0145
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0156 0.0163 0.0161
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0027 0.0039
Trichomonas vaginalis hypothetical protein 0.0035 0.0021 0.0178
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0275 0.0794
Plasmodium vivax heterochromatin protein 1, putative 0.0035 0.0021 0.0739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0758 0.0868 0.8018
Loa Loa (eye worm) bromodomain containing protein 0.006 0.0049 0.0071
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Schistosoma mansoni phd/f-box containing protein 0.0041 0.0027 0.008
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0118 0.4802
Toxoplasma gondii CMGC kinase, CK2 family 0.0149 0.0154 0.1824
Onchocerca volvulus Heterochromatin protein 1 homolog 0.009 0.0085 0.1415
Brugia malayi steroid hormone receptor 0.006 0.005 0.0449
Loa Loa (eye worm) hypothetical protein 0.0439 0.0494 0.0712
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0154 0.1413
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.005 0.0049
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0004 0.0003
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0009 0.0089
Schistosoma mansoni cpg binding protein 0.0216 0.0233 0.0703
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Schistosoma mansoni pyruvate kinase 0.0033 0.0018 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0224 0.2058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0039
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0009
Mycobacterium tuberculosis Conserved protein 0.0036 0.0021 0.0855
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Giardia lamblia DINP protein human, muc B family 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.009 0.0085 0.0122
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0349 0.0389 0.0388
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0036 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0073 0.0668
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0275 0.0754
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0156 0.0163 0.1493
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0057 0.0518
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0057 0.4822
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0118 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0004 0.0348
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.011 0.0109 0.0997
Loa Loa (eye worm) hypothetical protein 0.0054 0.0043 0.0061
Loa Loa (eye worm) phosphatidylinositol 3 0.0156 0.0163 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0021 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.005 0.0449
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0005
Plasmodium falciparum pyruvate kinase 0.0033 0.0018 0.0636
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Schistosoma mansoni wnt inhibitor frzb2 0.0125 0.0126 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0025
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0021 0.0178
Onchocerca volvulus 0.0125 0.0126 0.2168
Toxoplasma gondii FATC domain-containing protein 0.0419 0.0471 0.5607
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0118 0.017
Schistosoma mansoni hypothetical protein 0.2838 0.3306 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0029 0.0014 0.0117
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.006 0.005 0.0049
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0004 0.0003
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0025
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0403 0.0452 0.1304
Echinococcus multilocularis expressed conserved protein 0.0101 0.0098 0.0096
Entamoeba histolytica hypothetical protein 0.0021 0.0004 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0224 0.2058
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0033 0.0289
Brugia malayi Steroid receptor seven-up type 2 0.006 0.005 0.0449
Plasmodium falciparum phd finger protein, putative 0.0029 0.0013 0.048
Trypanosoma brucei trypanothione reductase 0.0048 0.0036 0.0397
Loa Loa (eye worm) beta-lactamase 0.0036 0.0021 0.003
Plasmodium vivax unspecified product 0.0149 0.0154 0.5591
Mycobacterium ulcerans lipase LipD 0.0036 0.0021 0.178
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0057 0.0056
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.006 0.005 0.0071
Schistosoma mansoni jumonji domain containing protein 0.0041 0.0027 0.008
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0085 0.0774
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.002
Brugia malayi Cytochrome P450 family protein 0.0032 0.0017 0.0149
Leishmania major pyruvate kinase 0.0033 0.0018 0.0049
Trypanosoma brucei ISWI complex protein 0.0021 0.0004 0.0033
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0009 0.0318
Brugia malayi FAT domain containing protein 0.029 0.0319 0.2942
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0021 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0021 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0025
Brugia malayi phosphofructokinase 0.0118 0.0118 0.108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0008 0.0023
Brugia malayi PAS domain containing protein 0.0053 0.0042 0.0373
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0758 0.0868 0.2504
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0466 0.0526 0.6052
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0118 0.1347
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0118 0.017
Loa Loa (eye worm) hypothetical protein 0.0148 0.0153 0.022
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0748 0.0856 0.0855
Leishmania major hypothetical protein, conserved 0.0046 0.0033 0.009
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0009
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0004 0.0009
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0045 0.161
Plasmodium vivax hypothetical protein, conserved 0.0156 0.0163 0.5903
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0748 0.0856 0.2469
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0057 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0792 0.7314
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0017 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0021 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0733 0.0839 0.7746
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.0389 0.056
Loa Loa (eye worm) hypothetical protein 0.0046 0.0033 0.0048
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0109 0.0997
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0017 0.0188
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0036 0.0034
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0057 0.0165
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.003
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0004 0.0003
Brugia malayi nuclear receptor NHR-88 0.006 0.005 0.0449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0007 0.0285
Echinococcus granulosus peregrin 0.0043 0.003 0.0029
Onchocerca volvulus 0.0028 0.0013 0.01
Brugia malayi Nuclear hormone receptor family member nhr-40 0.006 0.005 0.0449
Plasmodium vivax importin-beta 2, putative 0.0029 0.0013 0.0477
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.011 0.0109 0.1243
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0026 0.0231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Onchocerca volvulus 0.0156 0.0163 0.2827
Echinococcus multilocularis high voltage activated calcium channel beta 0.0094 0.009 0.0089
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0007 0.0593
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0758 0.0868 0.8018
Brugia malayi Cytochrome P450 family protein 0.0021 0.0004 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.006 0.005 0.0071
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1402 0.1623 0.4906
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0154 0.1413
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0006 0.0009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0453 0.0511 0.4714
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0118 0.108
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0013 0.01
Loa Loa (eye worm) hypothetical protein 0.0446 0.0502 0.0724
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.005 0.0148
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0002 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0008 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0246 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.0159 0.0158
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0017 0.0609
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0252 0.0275 0.2535
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0045 0.0064
Toxoplasma gondii ABC1 family protein 0.0036 0.0021 0.0238
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0021 0.0855
Schistosoma mansoni thyroid hormone receptor 0.006 0.005 0.0148
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0002 0.0003
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0042 0.0123
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0029 0.0014 0.0039
Echinococcus granulosus geminin 0.0519 0.0587 0.0586
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0148 0.0153 0.022
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0044 0.0032 0.0093
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.006 0.005 0.0049
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0013 0.0018
Echinococcus multilocularis frizzled 5 0.0273 0.03 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0117 0.0116 0.0167
Brugia malayi Csnk2b protein 0.004 0.0026 0.0231
Mycobacterium tuberculosis Probable reductase 0.0109 0.0108 0.4373
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0013 0.0036
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Echinococcus multilocularis ecdysone induced protein 78C 0.006 0.005 0.0049
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0027 0.0025
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0004 0.0003
Echinococcus granulosus bloom syndrome protein 0.0023 0.0007 0.0005
Echinococcus multilocularis cpg binding protein 0.0216 0.0233 0.0232
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0941 0.1082 0.3122
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.001
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0273 0.03 0.2761
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.011 0.0331
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0021 0.0762
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0017 0.0609
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0036 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0758 0.0868 0.8018
Schistosoma mansoni hypothetical protein 0.0148 0.0153 0.046
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0001
Echinococcus granulosus survival motor neuron protein 1 0.0512 0.058 0.0578
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0415 0.0466 0.4297
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0007
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0079 0.0072 0.0214
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0252 0.0275 0.2535
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0007 0.0055
Brugia malayi hypothetical protein 0.0028 0.0013 0.0106
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0252 0.0275 0.0274
Loa Loa (eye worm) phosphatidylinositol 3 0.0248 0.027 0.0389
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0039 0.0116
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.003
Loa Loa (eye worm) helicase 0.0035 0.0021 0.0029
Trypanosoma cruzi polo-like protein kinase, putative 0.0208 0.0224 0.0646
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.011 0.0109 0.0108
Onchocerca volvulus 0.0036 0.0021 0.0254
Plasmodium falciparum casein kinase II beta chain 0.004 0.0026 0.0945
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0026 0.0346
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0349 0.0389 0.6941
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.006 0.005 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0815 0.753
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0108 0.4373
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0026 0.0945
Brugia malayi hypoxia-induced factor 1 0.0164 0.0171 0.1574
Schistosoma mansoni hypothetical protein 0.0148 0.0153 0.046
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0046 0.0033 0.0097
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0004 0.0003
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0033 0.0289
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0009
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0026 0.0945
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0013 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0102 0.0931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0468 0.0528 0.4875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0815 0.753
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0057 0.0518
Brugia malayi hypothetical protein 0.0439 0.0494 0.4558
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0033 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0176 0.0186 0.1708
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.011 0.0109 0.0299
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0013 0.048
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0013 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0169 0.0178 0.0536
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0156 0.0163 0.5903
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0021 0.0178
Onchocerca volvulus 0.0101 0.0098 0.1647
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0052 0.0041 0.0039
Plasmodium falciparum importin beta, putative 0.0029 0.0013 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0443 0.0499 0.4604
Echinococcus granulosus FTZ F1 alpha 0.006 0.005 0.0049
Entamoeba histolytica hypothetical protein 0.0156 0.0163 0.1493
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.011 0.0109 0.0108
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0404 0.0453 0.4179
Echinococcus granulosus secreted frizzled protein 5 0.0125 0.0126 0.0125
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0941 0.1082 1
Entamoeba histolytica protein kinase rad3, putative 0.0403 0.0452 0.4171
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.002 0.0019
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0941 0.1082 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0272 0.0298 0.0297
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0708 0.081 0.7479
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0004
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0758 0.0868 0.0867
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0252 0.0275 0.3273
Giardia lamblia Phosphatidylinositol 4-kinase 0.0156 0.0163 0.1862
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0108 0.4373
Onchocerca volvulus 0.0061 0.0051 0.0795
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.0039 0.0038
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0004 0.0003
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0118 0.108
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0029 0.0013 0.0038
Brugia malayi nuclear hormone receptor 0.0028 0.0013 0.0106
Brugia malayi Cytochrome P450 family protein 0.0021 0.0004 0.0028
Brugia malayi M-phase phosphoprotein, mpp8 0.0132 0.0134 0.1229
Leishmania major phosphatidylinositol 4-kinase, putative 0.0156 0.0163 0.0446
Toxoplasma gondii thioredoxin reductase 0.0048 0.0036 0.0411
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0252 0.0275 0.083
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0018 0.0713
Schistosoma mansoni hypothetical protein 0.0112 0.011 0.0331
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.034 0.049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0073 0.0668
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0013 0.0012
Plasmodium vivax hypothetical protein 0.0156 0.0163 0.5903
Onchocerca volvulus 0.0132 0.0134 0.2308
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.0071
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0738 0.0845 0.2314
Echinococcus granulosus pyruvate kinase 0.0033 0.0018 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0224 0.2058
Loa Loa (eye worm) phosphatidylinositol kinase 0.0156 0.0163 0.0234
Echinococcus granulosus dna polymerase eta 0.0019 0.0002 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0108 0.4373
Brugia malayi hypothetical protein 0.0123 0.0124 0.1132
Echinococcus multilocularis thyroid hormone receptor alpha 0.006 0.005 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0021 0.023
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Entamoeba histolytica hypothetical protein 0.0021 0.0004 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0733 0.0839 0.7746
Leishmania major DNA polymerase kappa, putative 0.0019 0.0002 0.0005
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0029 0.0014 0.0117
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0004 0.0025
Echinococcus granulosus phd:f box containing protein 0.0041 0.0027 0.0026
Echinococcus multilocularis expressed protein 0.0406 0.0455 0.0454
Trypanosoma cruzi target of rapamycin kinase 3 0.0738 0.0845 0.2436
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.0071
Entamoeba histolytica hypothetical protein 0.0035 0.0021 0.0178
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0021 0.0739
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0748 0.0856 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.0163 0.1493
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0004 0.0149
Echinococcus multilocularis zinc finger protein 0.0077 0.0069 0.0068
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0156 0.0163 0.0161
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.003
Brugia malayi Fz domain containing protein 0.0125 0.0126 0.1158
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0108 0.6519
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0035 0.0021 0.0739
Brugia malayi Heterochromatin protein 1 0.0151 0.0156 0.1435
Echinococcus multilocularis survival motor neuron protein 1 0.0512 0.058 0.0578
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.005 0.0449
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.009 0.0089
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0018 0.0636
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.011 0.0109 0.0327
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.002 0.0059
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0018 0.019
Echinococcus multilocularis chromobox protein 2 0.0035 0.0021 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0224 0.2058
Brugia malayi hypothetical protein 0.0112 0.011 0.1009
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0145
Schistosoma mansoni patched 1 0.0046 0.0033 0.0099
Plasmodium falciparum casein kinase II beta chain 0.004 0.0026 0.0945
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0105 0.0104
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1402 0.1623 0.1621
Echinococcus granulosus casein kinase ii subunit alpha 0.0149 0.0154 0.0153
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0252 0.0275 1
Echinococcus granulosus chromobox protein 1 0.0151 0.0156 0.0155
Echinococcus multilocularis musashi 0.0029 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0005
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0045 0.0122
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0004 0.0003
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0156 0.0163 0.0489
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0021 0.0062
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0097 0.0093 0.0279
Schistosoma mansoni frizzled-like receptor 0.0148 0.0153 0.046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.006 0.005 0.0049
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0057 0.0647
Plasmodium falciparum heterochromatin protein 1 0.0035 0.0021 0.0739
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0021 0.0061
Brugia malayi photoreceptor-specific nuclear receptor 0.006 0.005 0.0449
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Brugia malayi CXXC zinc finger family protein 0.0199 0.0213 0.196
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0021 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.006 0.005 0.0071
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0006
Plasmodium vivax JmjC domain containing protein 0.0041 0.0027 0.0978
Loa Loa (eye worm) hypothetical protein 0.0686 0.0783 0.1129
Onchocerca volvulus Alhambra homolog 0.0029 0.0013 0.0113
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0014 0.0019
Echinococcus granulosus JmjC domain containing protein 4 0.0041 0.0027 0.0026
Echinococcus multilocularis chromobox protein 1 0.0151 0.0156 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-49 0.006 0.005 0.0449
Trichomonas vaginalis chromobox protein, putative 0.0096 0.0092 0.0838
Brugia malayi hypothetical protein 0.0177 0.0188 0.1723
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0145
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0007
Leishmania major GTP-binding protein, putative 0.0021 0.0004 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0086 0.1014
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0017 0.1346
Trichomonas vaginalis chromobox protein, putative 0.0151 0.0156 0.1435
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0013 0.0011
Echinococcus granulosus serine protein kinase ATM 0.0419 0.0471 0.047
Brugia malayi jmjC domain containing protein 0.0041 0.0027 0.0239
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.005 0.0071
Loa Loa (eye worm) hypothetical protein 0.0132 0.0134 0.0193
Brugia malayi hypothetical protein 0.0021 0.0004 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0021 0.0178
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0199 0.0213 0.0307
Onchocerca volvulus Huntingtin homolog 0.0123 0.0124 0.2118
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0007 0.0049
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0002 0.0067
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0086 0.1014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0738 0.0845 0.7801
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0425 0.0478 0.1443
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0045 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.0821 0.7585
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0107 0.0105 0.0104
Plasmodium vivax SET domain protein, putative 0.0066 0.0057 0.2056
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0057 0.0663
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0004 0.0005
Echinococcus multilocularis snurportin 1 0.0308 0.034 0.0339
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0027 0.0039
Brugia malayi hypothetical protein 0.0032 0.0017 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0733 0.0839 0.7746
Schistosoma mansoni survival motor neuron protein 0.0104 0.0102 0.0306
Schistosoma mansoni myst-related protein 0.0029 0.0014 0.0039
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0194 0.0207 0.1906
Plasmodium falciparum thioredoxin reductase 0.0048 0.0036 0.1288
Trichomonas vaginalis ran, putative 0.0021 0.0004 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0007 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0007 0.002
Brugia malayi SET domain containing protein 0.0042 0.0028 0.025
Echinococcus granulosus expressed conserved protein 0.0101 0.0098 0.0096
Brugia malayi nuclear receptor RXR 0.0028 0.0013 0.0106
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0003 0.011
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0045 0.0043
Schistosoma mansoni single-minded 0.0053 0.0042 0.0123
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0017 0.0188
Loa Loa (eye worm) hypothetical protein 0.0123 0.0124 0.0178
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0018 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0039 0.0116
Brugia malayi PHD-finger family protein 0.0029 0.0013 0.0113
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.011 0.0109 0.0327
Schistosoma mansoni thyroid hormone receptor 0.006 0.005 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0196 0.021 0.0208
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0041 0.0027 0.0078
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0021 0.0855
Echinococcus granulosus retinoic acid receptor rxr beta a 0.006 0.005 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0021 0.0855
Brugia malayi PHD-finger family protein 0.0026 0.0011 0.0087
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0194 0.0207 0.0298
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0021 0.0178
Schistosoma mansoni pyruvate kinase 0.0033 0.0018 0.0051
Onchocerca volvulus 0.0199 0.0213 0.3746
Schistosoma mansoni ran 0.0021 0.0004 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0021 0.0855
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.002 0.0019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0748 0.0856 0.7906
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0004 0.0009
Echinococcus multilocularis Chromo domain 0.0035 0.0021 0.0019
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0004 0.0003
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0705 0.0806 0.2207
Schistosoma mansoni chromobox protein 0.0151 0.0156 0.047
Echinococcus granulosus snurportin 1 0.0308 0.034 0.0339
Entamoeba histolytica hypothetical protein 0.0419 0.0471 0.4343
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0686 0.0783 0.0782
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0007 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.005 0.0449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.0163 0.1493
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0404 0.0453 0.4179
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0007 0.002
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0008 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.0487 0.0702
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0419 0.0471 0.1358
Loa Loa (eye worm) hypothetical protein 0.0211 0.0227 0.0326
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0004 0.0013
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0156 0.0163 0.0489
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.029 0.0319 0.0318
Echinococcus multilocularis ubiquitin specific protease 41 0.011 0.0109 0.0108
Onchocerca volvulus 0.0036 0.0021 0.0254
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.003
Echinococcus granulosus frizzled 0.0273 0.03 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Trypanosoma cruzi ISWI complex protein 0.0046 0.0033 0.0095
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0004 0.0025
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0156 0.0163 0.1927
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0057 0.017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.006 0.005 0.0449
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0156 0.0163 0.5903
Giardia lamblia Kinase, PLK 0.0208 0.0224 0.2567
Brugia malayi Nuclear hormone receptor family member nhr-3 0.006 0.005 0.0449
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.015 0.0451
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0004 0.0348
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0047 0.0046
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0118 0.108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0021 0.0855
Onchocerca volvulus 0.0132 0.0134 0.2308
Giardia lamblia Kinase, CMGC CK2 0.0149 0.0154 0.1763
Brugia malayi Serotonin receptor 0.0513 0.0581 0.5358
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.006 0.005 0.0049
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0073 0.0072
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.011 0.0109 0.0108
Brugia malayi intracellular kinase 0.0055 0.0045 0.04
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0028 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.001
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0005 0.0169
Entamoeba histolytica protein kinase, putative 0.0055 0.0045 0.04
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0308 0.034 0.3912
Loa Loa (eye worm) hypothetical protein 0.0369 0.0413 0.0595
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0758 0.0868 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0004 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0045 0.04
Schistosoma mansoni frizzled 0.0273 0.03 0.0904
Echinococcus multilocularis lamin 0.0029 0.0014 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0052 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.0071
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0017 0.0145
Onchocerca volvulus 0.006 0.005 0.0775
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0101 0.0098 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0815 0.753
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0036 0.0034
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0156 0.0163 0.0161
Toxoplasma gondii ck2 beta subunit 0.004 0.0026 0.0298
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.011 0.0109 0.0997
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0035 0.0021 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.0318
Brugia malayi nuclear receptor NHR-88 0.0028 0.0013 0.0106
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0045 0.0499
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1695 0.1967 0.1966
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0156 0.0163 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0815 0.7529
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0013 0.0011
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0097 0.0093 0.0092
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0446 0.0502 0.5984
Schistosoma mansoni frizzled-like receptor 0.0273 0.03 0.0904
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0021 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0815 0.7529
Brugia malayi jmjC domain containing protein 0.0041 0.0027 0.0239
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0014 0.0117
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0026
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0758 0.0868 0.8018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0272 0.0298 0.0429
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0004 0.0038
Schistosoma mansoni hypothetical protein 0.0035 0.0021 0.006
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0021 0.0178
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0118 0.108
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0013 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0004 0.0006
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0033 0.0032
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0748 0.0856 0.2469
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0047 0.0046
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0021 0.0004 0.0167
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0758 0.0868 0.2504
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0001 0.0088
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0004 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.002 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.0505 0.4658
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0118 0.0117
Schistosoma mansoni bromodomain containing protein 0.0207 0.0222 0.0669
Echinococcus granulosus chromobox protein 2 0.0035 0.0021 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0007 0.0182
Brugia malayi Bromodomain containing protein 0.0242 0.0263 0.2422
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0018 0.0025
Echinococcus multilocularis geminin 0.0519 0.0587 0.0586
Brugia malayi Protein kinase domain containing protein 0.0349 0.0389 0.3585
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0023
Echinococcus multilocularis protein dispatched 1 0.0052 0.0041 0.004
Trichomonas vaginalis chromobox protein, putative 0.0096 0.0092 0.0838
Trypanosoma brucei unspecified product 0.0019 0.0002 0.0007
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.002 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0017 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0738 0.0845 0.7801
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0013 0.0139
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0057 0.0647
Echinococcus granulosus mixed lineage leukemia protein mll 0.0052 0.004 0.0039
Schistosoma mansoni chromobox protein 0.0035 0.0021 0.006
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0066 0.0057 0.0171
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0008 0.0012
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0149 0.0154 0.5591
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0057 0.4822
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0021 0.1066
Trypanosoma brucei ISWI complex protein 0.0046 0.0033 0.0366
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0013 0.0011
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0086 0.0085
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0026 0.0231
Brugia malayi nuclear hormone receptor 0.006 0.005 0.0449
Brugia malayi Nuclear hormone receptor family member nhr-31 0.006 0.005 0.0449
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0018 0.0025
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0105 0.0961
Echinococcus granulosus frizzled 4 0.0273 0.03 0.0299
Giardia lamblia Hypothetical protein 0.0156 0.0163 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0048 0.043
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0018 0.0051
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0004 0.0037
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0052 0.0074
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0156 0.0163 0.1862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0815 0.753
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0149 0.0154 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0057 0.0169
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.0071
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0041 0.0027 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Brugia malayi PXA domain containing protein 0.0022 0.0006 0.0042
Echinococcus multilocularis Protein lozenge 0.0055 0.0044 0.0043
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0122 0.7421
Echinococcus granulosus expressed protein 0.0406 0.0455 0.0454
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0018 0.0191
Brugia malayi Bromodomain containing protein 0.0121 0.0122 0.1113
Schistosoma mansoni steroid hormone receptor ad4bp 0.006 0.005 0.0148
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0007 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0007 0.0593
Schistosoma mansoni phosphatidylserine receptor 0.0041 0.0027 0.008
Loa Loa (eye worm) hypothetical protein 0.0123 0.0124 0.0178
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.006 0.005 0.0775
Schistosoma mansoni retinoic acid receptor RXR 0.006 0.005 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.2975 0.3467 1
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0004 0.0003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0404 0.0453 0.4179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0045 0.04
Echinococcus granulosus frizzled 0.0273 0.03 0.0299
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0018 0.0197
Echinococcus multilocularis tumor protein p63 0.0367 0.041 0.0409
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0017 0.0609
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0001 0.0004
Plasmodium falciparum zinc finger protein, putative 0.0029 0.0014 0.0493
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.006 0.005 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0085 0.0774
Echinococcus granulosus chromobox protein 1 0.0151 0.0156 0.0155
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0002 0.0001
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0519 0.0587 0.1775
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0007 0.0055
Leishmania major hypothetical protein, conserved 0.0041 0.0027 0.0074
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Brugia malayi Protein kinase domain containing protein 0.0019 0.0002 0.0009
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0156 0.0163 0.5903
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0007 0.0053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0118 1
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.004 0.0026 0.0298
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.002 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.006 0.005 0.0049
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0403 0.0452 0.0451
Schistosoma mansoni nuclear hormone receptor 0.006 0.005 0.0148
Echinococcus multilocularis JmjC domain containing protein 4 0.0041 0.0027 0.0026
Entamoeba histolytica hypothetical protein 0.0112 0.011 0.1009
Loa Loa (eye worm) hypothetical protein 0.0156 0.0163 0.0234
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0052 0.0041 0.012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.005 0.0049
Echinococcus granulosus casein kinase ii subunit beta 0.004 0.0026 0.0025
Brugia malayi Pre-SET motif family protein 0.0066 0.0057 0.0514
Onchocerca volvulus 0.0054 0.0043 0.0643
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0009
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0017 0.0145
Schistosoma mansoni frizzled-like receptor 0.0273 0.03 0.0904
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.002 0.0019
Echinococcus multilocularis frizzled 10 0.0273 0.03 0.0299
Echinococcus multilocularis frizzled 0.0273 0.03 0.0299
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0057 0.0666
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0001 0.5
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0004 0.0009
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0013 0.0019
Echinococcus granulosus smoothened 0.606 0.7084 0.7083
Brugia malayi hypothetical protein 0.0025 0.0009 0.0071
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0057 0.0056
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0292 0.0322 0.0321
Schistosoma mansoni hypothetical protein 0.0104 0.0102 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0403 0.0452 0.4171
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0156 0.0163 0.1927
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0156 0.0163 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.0269 0.2478
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0118 0.0323
Entamoeba histolytica hypothetical protein 0.0021 0.0004 0.0025
Trypanosoma cruzi ISWI complex protein 0.0021 0.0004 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0017 0.0143
Leishmania major hypothetical protein, unknown function 0.0156 0.0163 0.0446
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0212 0.0228 0.0227
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0013 0.0011
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0035 0.0021 0.0019
Entamoeba histolytica hypothetical protein 0.0035 0.0021 0.0178
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0008 0.0012
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0404 0.0453 0.1307
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0557 0.0632 0.7278
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0057 0.2316
Brugia malayi CHD4 protein 0.0052 0.0041 0.0363
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0154 0.1413
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0014 0.0114
Schistosoma mansoni zinc finger protein 0.0077 0.0069 0.0208
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0252 0.0275 0.0274
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0941 0.1082 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0021 0.0184
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0056 0.0046 0.0065
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0349 0.0389 0.3585
Brugia malayi Pre-SET motif family protein 0.0433 0.0487 0.4497
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0025 0.0224
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Brugia malayi jmjC domain containing protein 0.0041 0.0027 0.0239
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0057 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0021 0.0178
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0007 0.0593
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0057 0.0165
Brugia malayi hypothetical protein 0.0028 0.0013 0.0106
Loa Loa (eye worm) hypothetical protein 0.0107 0.0105 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0033 0.0298
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0004 0.0003
Trypanosoma brucei protein kinase, putative 0.0055 0.0045 0.0499
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0252 0.0275 0.2535
Onchocerca volvulus Huntingtin homolog 0.0123 0.0124 0.2118
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0163 0.6619
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0013 0.0012
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0686 0.0783 0.0782
Onchocerca volvulus 0.0039 0.0025 0.0331
Leishmania major DNA polymerase eta, putative 0.0019 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0021 0.0178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0272 0.0298 0.0297
Mycobacterium tuberculosis Conserved protein 0.0036 0.0021 0.0855
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0052 0.004 0.0039
Trichomonas vaginalis hypothetical protein 0.0024 0.0008 0.0062
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0057 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0443 0.0499 0.4604
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0035 0.0021 0.0739
Echinococcus granulosus jumonji domain containing 1A 0.0041 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0025
Onchocerca volvulus 0.0029 0.0014 0.0117
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0789 0.0905 0.8356
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0273 0.03 0.2761
Loa Loa (eye worm) Csnk2b protein 0.004 0.0026 0.0037
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0208 0.0224 0.0322
Brugia malayi nuclear receptor NHR-67 0.0028 0.0013 0.0106
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Echinococcus granulosus lysine specific demethylase 6a 0.0041 0.0027 0.0026
Echinococcus multilocularis jumonji domain containing 1A 0.0041 0.0027 0.0026
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0096 0.0092 0.154
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0118 0.0355
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0156 0.0163 0.1927
Schistosoma mansoni ap endonuclease 0.0019 0.0001 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.006 0.005 0.0049
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0002 0.0002
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0004 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0007 0.0182
Brugia malayi Protein cec-1. 0.0035 0.0021 0.0178
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0107 0.0322
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0941 0.1082 0.3122
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0021 0.0178
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0052 0.004 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0156 0.0163 0.1493
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0021 0.178
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0118 0.0355
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0086 0.3125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.006 0.005 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0156 0.0163 0.1493
Brugia malayi follicle stimulating hormone receptor 0.0263 0.0287 0.2647
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.8548 1 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0035 0.0021 0.023
Schistosoma mansoni cpg binding protein 0.0216 0.0233 0.0703
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0125 0.0126 0.0182
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0153
Schistosoma mansoni jumonji domain containing protein 0.0192 0.0205 0.0618
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0004 0.0012
Schistosoma mansoni intermediate filament proteins 0.0029 0.0014 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.006 0.005 0.0148
Plasmodium falciparum glutathione reductase 0.0048 0.0036 0.1288
Echinococcus granulosus tumor protein p63 0.0367 0.041 0.0409
Brugia malayi jmjC domain containing protein 0.0212 0.0228 0.2097
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0018 0.0152
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0145 0.015 0.0216
Loa Loa (eye worm) hypothetical protein 0.0403 0.0452 0.0651
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0298 0.0899
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0224 0.2058
Entamoeba histolytica Ran family GTPase 0.0021 0.0004 0.0029
Onchocerca volvulus 0.0029 0.0014 0.0117
Loa Loa (eye worm) hypothetical protein 0.011 0.0109 0.0157
Giardia lamblia Casein kinase II beta chain 0.004 0.0026 0.0288
Schistosoma mansoni bromodomain containing protein 0.0031 0.0016 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Entamoeba histolytica hypothetical protein 0.0789 0.0905 0.8356
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0004 0.0025
Loa Loa (eye worm) sfrp2 0.0125 0.0126 0.0182
Loa Loa (eye worm) DR-78 0.0028 0.0013 0.0018
Onchocerca volvulus 0.0439 0.0494 0.8855
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.011 0.0109 0.0108
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.011 0.0109
Brugia malayi beta-lactamase family protein 0.0036 0.0021 0.0184
Echinococcus multilocularis casein kinase ii subunit beta 0.004 0.0026 0.0025
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0013 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0733 0.0839 0.7746
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0021 0.002
Echinococcus granulosus lysine specific demethylase 5A 0.0169 0.0178 0.0177
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0017 0.0025
Schistosoma mansoni hypothetical protein 0.0044 0.0032 0.0093
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.002 0.0059
Echinococcus multilocularis serine protein kinase ATM 0.0419 0.0471 0.047
Loa Loa (eye worm) hypothetical protein 0.0081 0.0074 0.0107
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0004 0.0034
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0029
Entamoeba histolytica hypothetical protein 0.0035 0.0021 0.0178
Mycobacterium tuberculosis Conserved protein 0.0036 0.0021 0.0855
Leishmania major hypothetical protein, conserved 0.3131 0.365 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0001 0.0038
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0052 0.004 0.0058
Echinococcus granulosus dna polymerase kappa 0.0019 0.0002 0.0001
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0004 0.0003
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Brugia malayi SET domain containing protein 0.0024 0.0007 0.0056
Leishmania major protein kinase ck2 regulatory subunit, putative 0.004 0.0026 0.0072
Brugia malayi hypothetical protein 0.0032 0.0017 0.0143
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0013 0.0011
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0002 0.0007
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0002 0.0067
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0252 0.0275 0.3273
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0021 0.0178
Echinococcus granulosus frizzled 5 0.0273 0.03 0.0299
Brugia malayi Importin beta-1 subunit 0.0029 0.0013 0.0112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0001 0.0004
Entamoeba histolytica hypothetical protein 0.0156 0.0163 0.1493
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0044 0.0395
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0021 0.0184
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0007 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0025
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0045 0.161
Brugia malayi tailless protein 0.0028 0.0013 0.0106
Entamoeba histolytica protein kinase domain containing protein 0.0149 0.0154 0.1413
Echinococcus multilocularis Zinc finger, PHD finger 0.0252 0.0275 0.0274
Brugia malayi beta-lactamase family protein 0.0036 0.0021 0.0184
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0041 0.0027 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0815 0.7529
Echinococcus multilocularis secreted frizzled protein 0.0125 0.0126 0.0125
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0177 0.0188 0.027
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0013 0.0018
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0156 0.0163 0.1862
Schistosoma mansoni ran 0.0021 0.0004 0.0011
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0252 0.0275 0.0397
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0156 0.0163 0.0161
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0117 0.0116 0.0115
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0064 0.0055 0.0053
Toxoplasma gondii hypothetical protein 0.0021 0.0004 0.0037
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0004 0.0025
Loa Loa (eye worm) calcium channel 0.0035 0.002 0.0029
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0013 0.0145
Trypanosoma cruzi polo-like protein kinase, putative 0.0208 0.0224 0.0646
Leishmania major phosphatidylinositol kinase, putative 0.0156 0.0163 0.0446
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0273 0.03 0.0432
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0108 0.4373
Entamoeba histolytica hypothetical protein 0.0023 0.0007 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0029
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0079 0.0072 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0017 0.0609
Echinococcus granulosus intermediate filament protein 0.0029 0.0014 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0007 0.0053
Leishmania major trypanothione reductase 0.0048 0.0036 0.0098
Schistosoma mansoni ap endonuclease 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0056 0.0045 0.0405
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0021 0.0184
Onchocerca volvulus 0.0028 0.0013 0.01
Trichomonas vaginalis Heterochromatin protein, putative 0.0035 0.0021 0.0178
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0017 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0048 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0013 0.0106
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0086 0.0786
Entamoeba histolytica acetyltransferase, GNAT family 0.0077 0.007 0.0633
Trypanosoma cruzi casein kinase II, putative 0.0149 0.0154 0.0444
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0004 0.0342
Entamoeba histolytica casein kinase, putative 0.0149 0.0154 0.1413
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0273 0.03 0.0432
Loa Loa (eye worm) hypothetical protein 0.0114 0.0114 0.0163
Loa Loa (eye worm) acetyltransferase 0.0292 0.0322 0.0464
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0051 0.0153
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0145
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0026 0.0076
Trypanosoma brucei Casein kinase II 0.0149 0.0154 0.1763
Schistosoma mansoni hypothetical protein 0.0148 0.0153 0.046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0073 0.0668
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0026 0.0346
Onchocerca volvulus 0.0104 0.0102 0.1723
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0017 0.0024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0688 0.0786 0.7262
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0461 0.052 0.4797
Schistosoma mansoni chromobox protein 0.0035 0.0021 0.006
Mycobacterium leprae conserved hypothetical protein 0.0156 0.0163 1
Schistosoma mansoni hypothetical protein 0.0044 0.0032 0.0093
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0263 0.0288 0.083
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0156 0.0163 0.5903
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0001 0.0004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0122 0.4955
Onchocerca volvulus Bile acid receptor homolog 0.006 0.005 0.0775
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.0224 0.0674
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0002 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0013 0.0011
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0033 0.0094
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.0159 0.0158
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0154 0.1413
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0043 0.0126
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0094 0.009 0.027
Brugia malayi Valyl-tRNA synthetase 0.0035 0.0021 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0073 0.0668
Loa Loa (eye worm) phosphatidylinositol 3 0.0758 0.0868 0.1251
Schistosoma mansoni hypothetical protein 0.029 0.0319 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0443 0.0499 0.4604
Echinococcus granulosus pyruvate kinase 0.0033 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0125 0.0126 0.0182
Brugia malayi RNA, U transporter 1 0.0082 0.0076 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0733 0.0839 0.7746
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.0071
Echinococcus granulosus cpg binding protein 0.0216 0.0233 0.0232
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0196 0.021 0.0208
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0419 0.0471 0.5417
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0275 0.0794
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.005 0.0049
Echinococcus granulosus high voltage activated calcium channel beta 0.0094 0.009 0.0089
Entamoeba histolytica hypothetical protein 0.0156 0.0163 0.1493
Loa Loa (eye worm) hypothetical protein 0.0148 0.0153 0.022
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0018 0.0847
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0013 0.0011
Onchocerca volvulus 0.0036 0.0021 0.0254
Loa Loa (eye worm) hypothetical protein 0.029 0.0319 0.046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0156 0.0163 0.0469
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0154 0.1413
Loa Loa (eye worm) hypothetical protein 0.5935 0.6937 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0035 0.0021 0.006
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0057 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0705 0.0806 0.744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0738 0.0845 0.7801
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0041 0.0027 0.0078
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0041 0.0027 0.0299
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0792 0.7314
Brugia malayi serine/threonine-protein kinase plk-2 0.0208 0.0224 0.2058
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0007 0.0055
Leishmania major importin beta-1 subunit, putative 0.0023 0.0007 0.0019
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0007 0.002
Leishmania major cytochrome p450-like protein 0.0021 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0005
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0252 0.0275 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0154 0.1413
Echinococcus granulosus lamin dm0 0.0029 0.0014 0.0012
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0156 0.0163 0.0469
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0156 0.0163 0.1493
Loa Loa (eye worm) steroid hormone receptor 0.006 0.005 0.0071
Loa Loa (eye worm) hypothetical protein 0.0148 0.0153 0.022
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0035 0.0021 0.0178
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0045 0.0132
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0708 0.081 0.7479
Schistosoma mansoni SET domain protein 0.0024 0.0007 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0349 0.0389 0.1174
Echinococcus multilocularis lysine specific demethylase 6a 0.0041 0.0027 0.0026
Giardia lamblia Pyruvate kinase 0.0033 0.0018 0.019
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0055 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0304 0.0336 0.0485
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0026
Brugia malayi PHD-finger family protein 0.0093 0.0088 0.0803
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0102 0.0934
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0252 0.0275 0.2535
Leishmania major casein kinase II, putative 0.0149 0.0154 0.0422
Schistosoma mansoni hypothetical protein 0.0056 0.0045 0.0133
Loa Loa (eye worm) histone methyltransferase 0.0064 0.0055 0.0078
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0033 0.0032
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0013 0.0145
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.0014 0.0117
Mycobacterium leprae Probable lipase LipE 0.0036 0.0021 0.1066
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0154 0.1413
Schistosoma mansoni voltage-gated cation channel 0.0035 0.002 0.0059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0394 0.0441 0.5254
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0007 0.0055
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0004 0.0003
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0029 0.0014 0.0013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0021 0.0855
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.0071
Schistosoma mansoni lozenge 0.0055 0.0044 0.0131
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0004 0.0003
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0758 0.0868 0.2378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0491 0.0555 0.5123
Echinococcus granulosus Chromo domain 0.0035 0.0021 0.0019
Brugia malayi Associated with TFs and helicases family protein 0.0035 0.0021 0.0178
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0045 0.04
Plasmodium falciparum histone acetyltransferase GCN5 0.0077 0.007 0.2527
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0014 0.0117
Mycobacterium ulcerans beta-lactamase 0.0036 0.0021 0.178
Brugia malayi ecdysteroid receptor 0.006 0.005 0.0449
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0272 0.0298 0.2744
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.005 0.0449
Echinococcus multilocularis chromobox protein 1 0.0151 0.0156 0.0155
Echinococcus granulosus dnaJ subfamily B 0.2838 0.3306 0.3306
Trichomonas vaginalis helicase, putative 0.0045 0.0033 0.0289
Loa Loa (eye worm) jmjC domain-containing protein 0.0169 0.0178 0.0256
Brugia malayi Fz domain containing protein 0.0125 0.0126 0.1158
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0002 0.0006
Echinococcus multilocularis 0.0156 0.0163 0.0161
Schistosoma mansoni protein kinase 0.0149 0.0154 0.0463
Brugia malayi PXA domain containing protein 0.0022 0.0006 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0005
Loa Loa (eye worm) CHromoDomain protein family member 0.0052 0.0041 0.0058
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0004 0.0348
Schistosoma mansoni coup transcription factor 0.006 0.005 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0044 0.0395
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0102 0.0934
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0005
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0004 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.0466 0.4297
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0013 0.01
Toxoplasma gondii hypothetical protein 0.0058 0.0048 0.0555
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0118 0.108
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.011 0.0109 0.0315
Brugia malayi Thioredoxin reductase 0.0048 0.0036 0.0318
Brugia malayi conserved hypotetical protein 0.0028 0.0013 0.0106
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0033 0.0032
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0021 0.0178
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0002 0.014
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0148 0.0153 0.1403
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0013 0.0106
Echinococcus granulosus Chromobox protein 3 0.0035 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0013
Onchocerca volvulus 0.0493 0.0557 1
Loa Loa (eye worm) RecQ helicase 0.0023 0.0007 0.0009
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0057 0.0518
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0021 0.0061
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1402 0.1623 0.1621
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0404 0.0453 0.5212
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0013 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.006 0.005 0.0049
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0009 0.0092
Trypanosoma cruzi ISWI complex protein 0.0046 0.0033 0.0095
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.011 0.0109 0.1243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.006 0.005 0.0071
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.008 0.0073 0.0668
Schistosoma mansoni nuclear receptor 0.0028 0.0013 0.0036
Giardia lamblia GTOR 0.0758 0.0868 1
Leishmania major hypothetical protein, conserved 0.0025 0.0009 0.0025
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0025 0.214
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0035 0.0021 0.006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0212 0.0228 0.0227
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0705 0.0806 0.928
Schistosoma mansoni zinc finger protein 0.0046 0.0033 0.0097
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Plasmodium vivax glutathione reductase, putative 0.0048 0.0036 0.1288
Echinococcus granulosus histone lysine methyltransferase setb 0.0117 0.0116 0.0115
Entamoeba histolytica hypothetical protein 0.0112 0.011 0.1009
Echinococcus multilocularis dna polymerase eta 0.0019 0.0002 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0013 0.0036
Echinococcus multilocularis pyruvate kinase 0.0026 0.001 0.0008
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.0039 0.0038
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0004 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0116 0.0349
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0007 0.0593
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0025
Echinococcus granulosus frizzled 0.0273 0.03 0.0299
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0224 0.2058
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0208 0.0224 0.0223
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0097 0.0093 0.0279
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0122 0.4955
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0758 0.0868 0.2378
Schistosoma mansoni Tr4/Tr2 (homologue) 0.006 0.005 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0004 0.0149
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0013 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0007 0.0593
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0021 0.178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0298 0.0899
Echinococcus granulosus fetal alzheimer antigen falz 0.0079 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0019
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0404 0.0453 0.4179
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0252 0.0275 0.2535
Schistosoma mansoni lamin 0.0029 0.0014 0.0039
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.006 0.005 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0792 0.7314
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0001 0.0042
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0403 0.0452 0.0451
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0018 0.0051
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0941 0.1082 1
Giardia lamblia Histone acetyltransferase GCN5 0.0077 0.007 0.079
Echinococcus multilocularis frizzled 0.0273 0.03 0.0299
Leishmania major phosphatidylinositol 3-kinase, putative 0.0252 0.0275 0.0754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0738 0.0845 0.7801
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0013 0.0106
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0116 0.0349
Loa Loa (eye worm) hypothetical protein 0.0061 0.0051 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0419 0.0471 0.4343
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0045 0.0499
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0004 0.0013
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0059 0.0049 0.0441
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0029
Schistosoma mansoni fkbp-rapamycin associated protein 0.0403 0.0452 0.1365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0738 0.0845 0.7801
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0105 0.0961
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.005 0.0449
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0758 0.0868 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0758 0.0868 0.8018
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.011 0.0109 0.0997
Echinococcus multilocularis smoothened 0.606 0.7084 0.7083
Brugia malayi jmjC domain containing protein 0.0041 0.0027 0.0239
Trichomonas vaginalis chromobox protein, putative 0.0151 0.0156 0.1435
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Brugia malayi beta-lactamase 0.0036 0.0021 0.0184
Echinococcus multilocularis casein kinase ii subunit alpha 0.0149 0.0154 0.0153
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0005 0.0169
Toxoplasma gondii target of rapamycin (TOR), putative 0.0733 0.0839 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0017 0.0181
Trypanosoma brucei polo-like protein kinase 0.0208 0.0224 0.2567
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0007 0.0049
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0021 0.0855
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0738 0.0845 0.9731
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0208 0.0224 0.0613
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0018 0.0152
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0018 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0026
Brugia malayi 6-phosphofructokinase 0.0118 0.0118 0.108
Brugia malayi hypothetical protein 0.0021 0.0004 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0792 0.7314
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0036 0.1444
Echinococcus multilocularis frizzled 4 0.0273 0.03 0.0299
Brugia malayi glutathione reductase 0.0048 0.0036 0.0318
Brugia malayi F/Y-rich N-terminus family protein 0.0078 0.0071 0.0648
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.0389 0.056
Echinococcus granulosus single minded 2 0.0039 0.0025 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0404 0.0453 0.4179
Schistosoma mansoni myst-related protein 0.0029 0.0014 0.0039
Onchocerca volvulus 0.0156 0.0163 0.2827
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0045 0.04
Onchocerca volvulus 0.0024 0.0007 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0705 0.0806 0.1161
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0029 0.0014 0.0013
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0018 0.1486
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0252 0.0275 0.083
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0145
Loa Loa (eye worm) runx1 0.0055 0.0044 0.0063
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0118 0.7184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.006 0.005 0.0071
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0785 0.0899 0.8307
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0021 0.0739
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0017 0.957
Echinococcus multilocularis expressed conserved protein 0.0089 0.0084 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0439 0.0494 0.0712
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0041 0.0027 0.008
Loa Loa (eye worm) phosphatidylinositol 3 0.0156 0.0163 0.0234
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0017 0.957
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0057 0.0518
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0004 0.0003
Echinococcus granulosus zinc finger protein 0.0077 0.0069 0.0068
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0118 0.108
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0017 0.0015
Schistosoma mansoni hypothetical protein 0.0089 0.0084 0.025
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0013 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0017 0.0048
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0105 0.0104
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0403 0.0452 0.4171
Echinococcus granulosus ubiquitin specific protease 41 0.011 0.0109 0.0108
Schistosoma mansoni frizzled-like receptor 0.0148 0.0153 0.046
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0013 0.0106
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Entamoeba histolytica hypothetical protein 0.0112 0.011 0.1009
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0349 0.0389 0.0388
Onchocerca volvulus 0.0055 0.0045 0.0678
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0758 0.0868 0.2623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0272 0.0298 0.0297
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0006 0.0045
Onchocerca volvulus Serine\/threonine kinase homolog 0.0208 0.0224 0.3939
Leishmania major hypothetical protein, conserved 0.0036 0.0021 0.0058
Echinococcus granulosus expressed conserved protein 0.0089 0.0084 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0049 0.0441
Brugia malayi intermediate filament protein 0.0029 0.0014 0.0114
Loa Loa (eye worm) gastrulation defective protein 1 0.0142 0.0146 0.021
Plasmodium falciparum JmjC domain-containing protein, putative 0.0041 0.0027 0.0978
Loa Loa (eye worm) hypothetical protein 0.0128 0.013 0.0187
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0248 0.027 0.0779
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0298 0.0899
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0224 0.2058
Entamoeba histolytica serine/threonine protein kinase, putative 0.0208 0.0224 0.2058
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0263 0.0288 0.0414
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0017 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0057 0.0056
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0118 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.005 0.0449
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0035 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0029
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.002 0.0019
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0172 0.0181 0.0523
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0036 0.0051
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.008 0.0073 0.0668
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0086 0.0786
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0021 0.0178
Schistosoma mansoni hypothetical protein 0.0519 0.0587 0.1775
Onchocerca volvulus Protein ultraspiracle homolog 0.006 0.005 0.0775
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0002 0.0006
Giardia lamblia PHD finger protein 15 0.0029 0.0013 0.014
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0007 0.0593
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0758 0.0868 0.0867
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0002 0.0005
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0018 0.0152
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0252 0.0275 0.2535
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Schistosoma mansoni casein kinase II beta subunit 0.004 0.0026 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0013 0.0139
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0004 0.0003
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0035 0.0021 0.023
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0007 0.002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0108 0.4373
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0013 0.0106
Echinococcus granulosus ecdysone induced protein 78C 0.006 0.005 0.0049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0013 0.0011
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0419 0.0471 0.1422
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0272 0.0298 0.0297
Trypanosoma brucei Casein kinase II subunit beta, putative 0.004 0.0026 0.0288
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0045 0.0043
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0008 0.0007
Brugia malayi Protein kinase domain containing protein 0.0145 0.015 0.1376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0021 0.0062
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0156 0.0163 0.0469
Mycobacterium ulcerans hypothetical protein 0.0036 0.0021 0.178
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0502 0.4635
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.006 0.005 0.0148
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0748 0.0856 0.2587
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.0287 0.0414
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0005
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0026 0.0231
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0485 0.0548 0.5056
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0048 0.043
Brugia malayi ecdysone receptor 0.0028 0.0013 0.0106
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0004 0.0153
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0208 0.0224 0.0223
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0693 0.0792 0.9122
Plasmodium vivax SET domain containing protein 0.0021 0.0004 0.0129
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0004 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0018 0.0025
Schistosoma mansoni cpg binding protein 0.0199 0.0213 0.0642
Loa Loa (eye worm) glutathione reductase 0.0048 0.0036 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.006 0.005 0.0071
Brugia malayi hypothetical protein 0.0512 0.058 0.535
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0004 0.0036
Echinococcus multilocularis peregrin 0.0043 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0145 0.015 0.0216
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.011 0.0109 0.0997
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0021 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.0269 0.2478
Schistosoma mansoni RAR-like nuclear receptor 0.006 0.005 0.0148
Echinococcus multilocularis pyruvate kinase 0.0033 0.0018 0.0016
Brugia malayi CHE-14 protein 0.0046 0.0033 0.0298
Schistosoma mansoni lamin 0.0029 0.0014 0.0039
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0018 0.0152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.005 0.0049
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0013 0.0036
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0021 0.0004 0.0167
Loa Loa (eye worm) hypothetical protein 0.0512 0.058 0.0835
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0252 0.0275 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0156 0.0163 0.5903
Leishmania major pyruvate kinase 0.0033 0.0018 0.0049
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0007 0.0053
Brugia malayi chromobox protein homolog 3 0.009 0.0085 0.0774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0758 0.0868 0.8018
Echinococcus multilocularis secreted frizzled protein 5 0.0125 0.0126 0.0125
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.002 0.0177
Loa Loa (eye worm) phosphatidylinositol 3 0.0156 0.0163 0.0234
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0013 0.0038
Echinococcus granulosus jumonji domain containing protein 0.004 0.0027 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0289
Brugia malayi Casein kinase II, alpha chain 0.0149 0.0154 0.1413
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0064 0.0055 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0021 0.0178
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0026 0.0076
Brugia malayi hypothetical protein 0.0132 0.0134 0.123
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0006 0.0008
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0118 0.0117
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0107 0.0105 0.0104
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0052 0.0041 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0073 0.0668
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0008 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0733 0.0839 0.7746
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.005 0.0449
Brugia malayi Nuclear hormone receptor family member nhr-1 0.006 0.005 0.0449
Echinococcus granulosus secreted frizzled protein 0.0125 0.0126 0.0125
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0021 0.0178
Echinococcus multilocularis lysine specific demethylase 5A 0.0152 0.0158 0.0157
Echinococcus multilocularis FTZ F1 alpha 0.006 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0007 0.0593
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0057 0.4822
Schistosoma mansoni secreted frizzled-related protein 0.0125 0.0126 0.038
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0045 0.0043
Entamoeba histolytica hypothetical protein 0.0029 0.0014 0.0116
Brugia malayi jmjC domain containing protein 0.0169 0.0178 0.1634
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0057 0.0518
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.008 0.0073 0.0668
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0027 0.0039
Echinococcus granulosus cyclin dependent kinase 19 0.0145 0.015 0.0149
Brugia malayi Bromodomain containing protein 0.0043 0.003 0.0265
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.002 0.0019
Echinococcus multilocularis protein patched 0.0046 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0029
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0122 0.4955
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0007 0.0049
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0456 0.0514 0.1552
Entamoeba histolytica hypothetical protein 0.0112 0.011 0.1009
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0275 0.3162
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0016 0.0045
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Schistosoma mansoni DNA polymerase eta 0.0019 0.0002 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0492 0.0557 0.5139
Leishmania major phosphatidylinositol kinase related protein, putative 0.0172 0.0181 0.0497
Toxoplasma gondii hypothetical protein 0.0021 0.0004 0.0037
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.0821 0.7585
Echinococcus multilocularis pyruvate kinase 0.0033 0.0018 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0118 0.108
Echinococcus granulosus protein kinase shaggy 0.0055 0.0045 0.0043
Leishmania major phosphatidylinositol 3-kinase, putative 0.0693 0.0792 0.217
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0021 0.0184
Echinococcus multilocularis cyclin dependent kinase 19 0.0145 0.015 0.0149
Schistosoma mansoni nuclear receptor 0.0028 0.0013 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0169 0.0178 0.0536
Brugia malayi SH2 domain containing protein 0.0369 0.0413 0.3806
Schistosoma mansoni hypothetical protein 0.0061 0.0052 0.0154
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0196 0.0209 0.2401
Schistosoma mansoni zinc finger protein 0.0028 0.0013 0.0036
Chlamydia trachomatis pyruvate kinase 0.0033 0.0018 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0733 0.0839 0.7746
Schistosoma mansoni hypothetical protein 0.0044 0.0032 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0145
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0024
Mycobacterium ulcerans hypothetical protein 0.0024 0.0007 0.0593
Brugia malayi acetyltransferase, GNAT family protein 0.0292 0.0322 0.297
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0156 0.0163 0.1493
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0049 0.0048
Echinococcus multilocularis secreted frizzled protein 0.0125 0.0126 0.0125
Loa Loa (eye worm) phosphatidylinositol 3 0.0156 0.0163 0.0234
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0004 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.0318
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0002 0.0005
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0055 0.0045 0.0516
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0156 0.0163 0.0161
Loa Loa (eye worm) phosphatidylinositol 3 0.125 0.1445 0.2082
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0292 0.0322 0.0972
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0097 0.0093 0.0092
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0156 0.0163 0.0489
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0035 0.0021 0.023
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0013 0.0106
Echinococcus granulosus lamin 0.0029 0.0014 0.0012
Brugia malayi nuclear receptor RXR 0.0032 0.0017 0.0143
Schistosoma mansoni hypothetical protein 0.0308 0.034 0.1027
Schistosoma mansoni kinase 0.0107 0.0105 0.0316
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0013 0.0018
Schistosoma mansoni importin beta-1 0.0029 0.0013 0.0038
Echinococcus multilocularis phd:f box containing protein 0.0041 0.0027 0.0026
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.002 0.0019
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.011 0.0109 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.029 0.0319 0.2942
Echinococcus multilocularis lamin dm0 0.0029 0.0014 0.0012
Loa Loa (eye worm) heterochromatin protein 1 0.0151 0.0156 0.0225
Trichomonas vaginalis esterase, putative 0.0036 0.0021 0.0184
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0118 0.0341
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0018 0.019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0001 0.0038
Loa Loa (eye worm) hypothetical protein 0.006 0.005 0.0071
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0026 0.0231
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.029 0.0319 0.0318
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0419 0.0471 0.4343
Schistosoma mansoni chromobox protein 0.0151 0.0156 0.047
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.0171 0.0247
Echinococcus granulosus importin subunit beta 1 0.0029 0.0013 0.0012
Echinococcus multilocularis dnaJ subfamily B 0.2838 0.3306 0.3306
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0156 0.0163 0.1493
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0941 0.1082 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.006 0.005 0.0449
Schistosoma mansoni protein phosphatase 2C 0.0041 0.0027 0.008
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0057 0.0165
Brugia malayi 6-phosphofructokinase 0.0118 0.0118 0.108
Loa Loa (eye worm) hypothetical protein 0.0132 0.0134 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0028
Plasmodium falciparum casein kinase 2, alpha subunit 0.0149 0.0154 0.5591

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9.1 10'-10M Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor ChEMBL. 18983139
Ki (binding) = 4.1 10'-10M Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor ChEMBL. 18983139
Ki (binding) = 20 nM Evaluated for the binding affinity against NK1 receptor ChEMBL. 7693945

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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