Detailed information for compound 334569

Basic information

Technical information
  • TDR Targets ID: 334569
  • Name: 5-(4-methylpiperazin-1-yl)-5-[4-[(2-methylqui nolin-4-yl)methoxy]phenyl]-1,3-diazinane-2,4, 6-trione
  • MW: 473.524 | Formula: C26H27N5O4
  • H donors: 2 H acceptors: 4 LogP: 2.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(cc1)OCc1cc(C)nc2c1cccc2
  • InChi: 1S/C26H27N5O4/c1-17-15-18(21-5-3-4-6-22(21)27-17)16-35-20-9-7-19(8-10-20)26(31-13-11-30(2)12-14-31)23(32)28-25(34)29-24(26)33/h3-10,15H,11-14,16H2,1-2H3,(H2,28,29,32,33,34)
  • InChiKey: HNINPFHHNYDBSH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(4-methylpiperazin-1-yl)-5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]hexahydropyrimidine-2,4,6-trione
  • 5-(4-methyl-1-piperazinyl)-5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]hexahydropyrimidine-2,4,6-trione
  • 5-(4-methylpiperazino)-5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]barbituric acid
  • 5-(4-methylpiperazin-1-yl)-5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]barbituric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ADAM metallopeptidase domain 17 Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References
Sus scrofa ADAM17 Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 13 (collagenase 3) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma japonicum ko:K06059 a disintegrin and metalloproteinase domain 17, putative Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma mansoni ADAM17 peptidase (M12 family) Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus Blood coagulation inhibitor Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii A/G-specific adenine glycosylase, putative ADAM17   112 aa 109 aa 24.8 %
Echinococcus multilocularis disintegrin and metalloproteinase ADAM17   112 aa 99 aa 42.4 %
Onchocerca volvulus Putative glutaminase 3 ADAM17   112 aa 105 aa 45.7 %
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %
Brugia malayi Disintegrin family protein ADAM metallopeptidase domain 17 824 aa 724 aa 27.4 %
Echinococcus granulosus disintegrin and metalloproteinase ADAM17   112 aa 99 aa 42.4 %
Trypanosoma congolense hypothetical protein, conserved ADAM17   112 aa 100 aa 29.0 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 13 (collagenase 3) 471 aa 448 aa 34.1 %
Onchocerca volvulus ADAM17   112 aa 98 aa 41.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Onchocerca volvulus 0.0031 0.0038 0.0674
Brugia malayi CHE-14 protein 0.0171 0.0328 0.1602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0268 0.0931
Brugia malayi Patched related family protein 12 0.0024 0.0023 0.01
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0255 0.0504 0.0593
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0146 0.0503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0036 0.0165
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Onchocerca volvulus 0.0172 0.033 0.6253
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0691 0.1413 0.6935
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0275 0.0546 0.3845
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0268 0.1306
Echinococcus granulosus bloom syndrome protein 0.002 0.0014 0.0041
Plasmodium falciparum chorismate synthase 0.4809 1 1
Echinococcus granulosus dna polymerase eta 0.0098 0.0178 0.0613
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0127 0.061
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0056 0.0044
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.005 0.0056
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0005 0.0003
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0187 0.0363 0.1263
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0115 0.0213 0.1035
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0014 0.001
Schistosoma mansoni ran 0.0021 0.0017 0.005
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0257 0.0508 0.0504
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Toxoplasma gondii histone lysine-specific demethylase 0.0067 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.005 0.0165
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0321
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Plasmodium falciparum geranylgeranyltransferase, putative 0.0187 0.0363 0.0359
Brugia malayi hypothetical protein 0.0039 0.0053 0.025
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0106 0.0194 0.0183
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0206
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0015
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0042 0.006 0.0097
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0329 0.066 0.23
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0268 0.0314
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0268 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0036 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0076 0.0374
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0052 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0075 0.0086
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0042 0.006 0.0055
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0052 0.0245
Leishmania major hypothetical protein, unknown function 0.0015 0.0005 0.0001
Toxoplasma gondii hypothetical protein 0.0024 0.0023 0.0018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0012 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0075 0.0504
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Schistosoma mansoni topbp1 0.004 0.0056 0.0188
Mycobacterium ulcerans monoamine oxidase 0.0067 0.0111 0.0099
Brugia malayi cell division control protein 2 homolog 0.0049 0.0075 0.0357
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Leishmania major DNA polymerase kappa, putative 0.0079 0.0138 0.0948
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.0985
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.0467 0.2281
Entamoeba histolytica acyl-coA synthetase, putative 0.0142 0.0269 0.1303
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0046 0.0052
Entamoeba histolytica hypothetical protein 0.004 0.0056 0.0254
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Brugia malayi ImpB/MucB/SamB family protein 0.0098 0.0178 0.086
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.004 0.0249
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0269 0.1303
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0275 0.0546 0.3845
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0075 0.0357
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0015
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0034 0.003
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0368 0.0741 0.2584
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0187 0.0363 0.1783
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.027 0.0536 0.1866
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.005 0.0222
Onchocerca volvulus 0.0042 0.006 0.1091
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0088
Plasmodium falciparum protein kinase 5 0.0049 0.0075 0.0071
Leishmania major farnesyltransferase beta subunit 0.0691 0.1413 1
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0164 0.0314 0.0368
Leishmania major DNA damage repair protein, putative 0.0023 0.002 0.0108
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0275 0.0546 0.3845
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0257 0.0508 0.3574
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0008 0.0025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0012 0.0034
Entamoeba histolytica hypothetical protein 0.0023 0.0021 0.0083
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0014 0.0014
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.0333 0.6307
Toxoplasma gondii patched family protein 0.0024 0.0023 0.0018
Echinococcus multilocularis alkaline phosphatase 0.0164 0.0314 0.0368
Echinococcus multilocularis histone deacetylase 3 0.0538 0.1094 0.1291
Schistosoma mansoni cpg binding protein 0.0061 0.01 0.0343
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0075 0.0348
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0073 0.0124 0.0144
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0079 0.0138 0.0948
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0187 0.0363 0.1263
Toxoplasma gondii hypothetical protein 0.0734 0.1502 0.1498
Plasmodium vivax protein kinase Crk2 0.0049 0.0075 0.0071
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0206
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.099 0.2038 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0172 0.033 0.2313
Giardia lamblia Rab geranylgeranyltransferase 0.0257 0.0508 0.2476
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Echinococcus multilocularis smad 0.0016 0.0006 0.0004
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0691 0.1413 0.6935
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0124
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0187 0.0363 0.1765
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0079 0.0074
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0042 0.006 0.0097
Brugia malayi Pre-SET motif family protein 0.0211 0.0412 0.2012
Schistosoma mansoni histone deacetylase hda2 0.0643 0.1314 0.459
Echinococcus multilocularis neuroglian 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0763 0.1562 0.7666
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0012 0.0048
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0201 0.0385
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0014 0.001
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.055 0.1119 0.3908
Plasmodium falciparum aldo-keto reductase, putative 0.005 0.0076 0.0072
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0079 0.0527
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0246 0.0486 0.0967
Schistosoma mansoni hypothetical protein 0.0165 0.0316 0.1096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0182 0.0347
Mycobacterium ulcerans acetyl-CoA synthetase 0.0042 0.006 0.0048
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Echinococcus granulosus twitchin 0.0022 0.0019 0.0058
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.005 0.0165
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0201 0.0305
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.002 0.006
Treponema pallidum DNA ligase (lig) 0.004 0.0056 0.0575
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.005 0.0244
Echinococcus granulosus dual specificity 0.0275 0.0546 0.1903
Onchocerca volvulus 0.0042 0.006 0.1091
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0034 0.003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0005 0.0003
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0148
Trichomonas vaginalis esterase, putative 0.0038 0.0052 0.0258
Brugia malayi Flap endonuclease-1 0.0026 0.0027 0.012
Loa Loa (eye worm) hypothetical protein 0.0172 0.033 0.1611
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Onchocerca volvulus 0.0172 0.033 0.6253
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.006 0.0272
Plasmodium vivax histone deacetylase 2, putative 0.0631 0.1288 0.1284
Onchocerca volvulus 0.0038 0.0052 0.0953
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0056 0.0367
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0005 0.001
Onchocerca volvulus 0.0058 0.0094 0.1737
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0036 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0104 0.0497
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0067 0.0111 0.0129
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.018 0.1246
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0172 0.033 0.1621
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0038 0.0124
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0033 0.0028
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0015 0.0004 0.0002
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0115 0.0213 0.041
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Schistosoma mansoni hypothetical protein 0.0085 0.015 0.0516
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0538 0.1094 0.5372
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0041 0.019
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0056 0.0052
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0014 0.0069
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0005 0.0008
Echinococcus granulosus aldo keto reductase 0.0172 0.033 0.1147
Entamoeba histolytica histone deacetylase, putative 0.0538 0.1094 0.5361
Trichomonas vaginalis aldo/keto reductase, putative 0.0172 0.033 0.1621
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0007
Schistosoma mansoni DNA polymerase eta 0.0098 0.0178 0.0613
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0879 0.1805 0.3655
Loa Loa (eye worm) hypothetical protein 0.0031 0.0038 0.0174
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0073 0.0487
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0254 0.0501 0.059
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0434 0.0877 0.1035
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Schistosoma mansoni histone deacetylase 0.0538 0.1094 0.3822
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0103 0.0351
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0075 0.0254
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0067 0.0111 0.0107
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0201 0.0694
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.005 0.0165
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Echinococcus granulosus Immunoglobulin 0.0015 0.0005 0.0008
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0254 0.0501 0.245
Echinococcus granulosus conserved hypothetical protein 0.0015 0.0005 0.0007
Echinococcus granulosus adam 17 protease 0.0802 0.1646 0.5751
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0146 0.0707
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0014 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0146 0.0503
Trypanosoma cruzi aldo/keto reductase, putative 0.005 0.0076 0.0509
Brugia malayi Myosin head containing protein 0.0024 0.0023 0.01
Plasmodium falciparum protoporphyrinogen oxidase 0.0067 0.0111 0.0107
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.2372 0.4917 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0056 0.0367
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0398 0.0802 0.3922
Trypanosoma brucei aldo/keto reductase, putative 0.005 0.0076 0.0509
Schistosoma mansoni histone deacetylase 0.0538 0.1094 0.3822
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0042 0.006 0.0055
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0052 0.0175
Mycobacterium ulcerans hypothetical protein 0.0023 0.002 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0036 0.0117
Mycobacterium ulcerans lipase LipD 0.0038 0.0052 0.004
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0344 0.0691 0.2409
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0075 0.0348
Brugia malayi Carboxylesterase family protein 0.0066 0.0109 0.0525
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0056 0.0276
Mycobacterium leprae Possible oxidoreductase 0.005 0.0076 0.0049
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0119 0.0114
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0075 0.0086
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.005 0.0076 0.0509
Loa Loa (eye worm) hypothetical protein 0.0398 0.0802 0.3928
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0033 0.02
Loa Loa (eye worm) hypothetical protein 0.0066 0.0109 0.0525
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0041 0.019
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0014 0.0057
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Brugia malayi beta-lactamase 0.0038 0.0052 0.0245
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0172 0.033 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.099 0.2038 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0036 0.004
Plasmodium vivax prenyltransferase alpha subunit, putative 0.099 0.2038 0.2034
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.002 0.0108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0052 0.0082
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0007
Echinococcus multilocularis muscleblind protein 0.0452 0.0915 0.1079
Echinococcus multilocularis adam 17 protease 0.078 0.1599 0.1888
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0138 0.0948
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0104 0.0354
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.01 0.0181 0.0625
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0269 0.1303
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0159
Loa Loa (eye worm) hypothetical protein 0.0142 0.0269 0.1311
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0006 0.0013
Echinococcus granulosus replication factor c subunit 1 0.004 0.0056 0.0188
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.0965
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0036 0.0117
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0014 0.0014
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0109 0.0374
Leishmania major GTP-binding protein, putative 0.0021 0.0017 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0142 0.0269 0.1311
Onchocerca volvulus 0.0024 0.0023 0.0388
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0004 0.001
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0106 0.0194 0.0372
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0033
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0164 0.0314 0.0368
Echinococcus multilocularis histone deacetylase 1 0.0538 0.1094 0.1291
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0277 0.0324
Entamoeba histolytica deoxycytidyl transferase, putative 0.0073 0.0124 0.0589
Echinococcus granulosus expressed conserved protein 0.0374 0.0752 0.2622
Trypanosoma cruzi histone deacetylase 1, putative 0.0538 0.1094 0.7738
Onchocerca volvulus 0.0038 0.0052 0.0953
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0124
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0142 0.0269 0.0258
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0275 0.0546 0.2671
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0206
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0036 0.0117
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0177 0.0612
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0146 0.0707
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0368 0.0741 0.2584
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.0363 0.2548
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Loa Loa (eye worm) hypothetical protein 0.0115 0.0213 0.1035
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0109 0.0374
Echinococcus multilocularis aldo keto reductase 0.0172 0.033 0.0388
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.099 0.2038 0.2407
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.002 0.0015
Trypanosoma cruzi histone deacetylase, putative 0.0631 0.1288 0.9114
Onchocerca volvulus 0.005 0.0076 0.1406
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0172 0.033 0.2313
Onchocerca volvulus Matrilysin homolog 0.021 0.0411 0.7788
Loa Loa (eye worm) RecQ helicase 0.002 0.0014 0.0057
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0015 0.0005 0.0008
Plasmodium vivax acetyl-CoA synthetase, putative 0.0042 0.006 0.0055
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0015 0.0005 0.0008
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0237 0.1154
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.002 0.0108
Schistosoma mansoni DNA helicase recq1 0.002 0.0014 0.0041
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0067 0.0111 0.0381
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.004 0.0249
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.004 0.0173
Echinococcus granulosus FTZ F1 alpha 0.003 0.0036 0.0117
Schistosoma mansoni importin beta-1 0.0029 0.0033 0.0106
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0538 0.1095 0.537
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0018
Trypanosoma cruzi aldo-keto reductase 0.0172 0.033 0.2313
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0232 0.0802
Brugia malayi glutaminase DH11.1 0.0554 0.1128 0.5529
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.002 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0075 0.0369
Leishmania major aldo-keto reductase-like protein 0.0172 0.033 0.2313
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.006 0.0281
Loa Loa (eye worm) carboxylesterase 0.0066 0.0109 0.0525
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0012 0.0035
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0201 0.0189
Onchocerca volvulus 0.0015 0.0005 0.004
Plasmodium falciparum lipid/sterol:H+ symporter 0.0024 0.0023 0.0018
Echinococcus multilocularis Niemann Pick C1 protein 0.0568 0.1158 0.1366
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0005 0.001
Onchocerca volvulus 0.0095 0.017 0.3198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0268 0.0931
Leishmania major hypothetical protein, conserved 0.0051 0.0079 0.0527
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0012 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0042 0.006 0.0281
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0127 0.0434
Plasmodium vivax acyl-CoA synthetase, putative 0.0106 0.0194 0.019
Toxoplasma gondii histone deacetylase HDAC4 0.0266 0.0527 0.0522
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0017 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0075 0.0504
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0006 0.0013
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0057
Brugia malayi glutamate-cysteine ligase modifier subunit 0.005 0.0076 0.0362
Brugia malayi hypothetical protein 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0095 0.017 0.0824
Echinococcus multilocularis expressed protein 0.0033 0.0041 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0036 0.004
Trypanosoma cruzi DNA polymerase eta, putative 0.0098 0.0178 0.1229
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0075 0.0502
Echinococcus granulosus dna polymerase kappa 0.0099 0.018 0.0621
Toxoplasma gondii patched family protein 0.0024 0.0023 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0036 0.0117
Echinococcus granulosus histone deacetylase 1 0.0538 0.1094 0.3822
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Echinococcus multilocularis aldo keto reductase 0.0172 0.033 0.0388
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0614 0.3007
Trypanosoma cruzi UDP-galactopyranose mutase 0.0067 0.0111 0.0759
Loa Loa (eye worm) hypothetical protein 0.0199 0.0387 0.1888
Loa Loa (eye worm) hypothetical protein 0.099 0.2038 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0091 0.0614
Echinococcus granulosus histone deacetylase 7 0.0631 0.1288 0.4501
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0187 0.0363 0.2548
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0052 0.0048
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0237 0.1154
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0012 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.002 0.0108
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0049 0.0075 0.0502
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0004 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0111 0.0107
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.006 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0508 0.3574
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0257 0.0508 0.2484
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0172 0.033 0.1611
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis snurportin 1 0.0308 0.0614 0.0724
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0013
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0042 0.006 0.0097
Schistosoma mansoni DNA ligase IV 0.004 0.0056 0.0188
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0005 0.001
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0015 0.0004 0.0007
Echinococcus granulosus tar DNA binding protein 0.0127 0.0237 0.0822
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0109 0.0525
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.006 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0036 0.0165
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Echinococcus multilocularis nibrin 0.004 0.0056 0.0063
Mycobacterium ulcerans oxidoreductase 0.0172 0.033 0.0319
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0269 0.0525
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0052 0.0082
Mycobacterium ulcerans glutaminase 0.0554 0.1128 0.1117
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0004 0.001
Chlamydia trachomatis dehyroquinate synthase 0.0246 0.0486 0.0454
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0258
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus histone deacetylase 6 0.0631 0.1288 0.4501
Trypanosoma brucei unspecified product 0.005 0.0077 0.0516
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0352 0.173
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0056 0.0276
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0321
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0187 0.0363 0.1773
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0257 0.0508 0.0598
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.006 0.0281
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0062 0.0304
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0034 0.0168
Brugia malayi Smad1 0.0016 0.0006 0.0018
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0387 0.0779 0.0747
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0075 0.0254
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0538 0.1094 0.5372
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0434 0.0877 0.3063
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0042 0.006 0.0097
Echinococcus multilocularis Niemann Pick C1 protein 0.0398 0.0802 0.0945
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0014 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0036 0.0117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0034 0.0146
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.0965
Trypanosoma cruzi histone deacetylase, putative 0.0266 0.0527 0.3707
Schistosoma mansoni coup transcription factor 0.003 0.0036 0.0117
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0124 0.0229
Brugia malayi Pre-SET motif family protein 0.0031 0.0038 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0538 0.1095 0.1292
Brugia malayi polk-prov protein 0.0049 0.0075 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0056 0.0063
Brugia malayi Matrixin family protein 0.0229 0.045 0.22
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0269 0.0258
Schistosoma mansoni vesicular amine transporter 0.0015 0.0005 0.0008
Brugia malayi MH2 domain containing protein 0.0237 0.0467 0.2281
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0079 0.0074
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.004 0.0035
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.005 0.0076 0.0072
Echinococcus granulosus acetylcholinesterase 0.0066 0.0109 0.0374
Brugia malayi Importin beta-1 subunit 0.0029 0.0033 0.0148
Loa Loa (eye worm) hypothetical protein 0.0378 0.076 0.3722
Plasmodium vivax chorismate synthase 0.4809 1 1
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0257 0.0508 0.3574
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0691 0.1413 0.6935
Trichomonas vaginalis aldo/keto reductase, putative 0.0172 0.033 0.1621
Mycobacterium ulcerans chorismate synthase 0.4809 1 1
Brugia malayi ADAMTS-like protease 0.0017 0.0007 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0104 0.0497
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.3574
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0033 0.02
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0005 0.0008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0268 0.093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0081
Echinococcus multilocularis Immunoglobulin 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0452 0.0915 0.4485
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.018 0.1246
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0012 0.0046
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0014 0.007
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0006 0.0013
Trichomonas vaginalis DNA polymerase eta, putative 0.0099 0.018 0.0883
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0111 0.0107
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0075 0.0502
Brugia malayi Ets-domain containing protein 0.0074 0.0127 0.061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0038 0.0042
Echinococcus granulosus Niemann Pick C1 protein 0.0568 0.1158 0.4044
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Loa Loa (eye worm) glutaminase 0.0554 0.1128 0.5529
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0286
Echinococcus multilocularis histone deacetylase 7 0.0631 0.1288 0.1521
Mycobacterium tuberculosis Probable oxidoreductase 0.0172 0.033 0.0649
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0063 0.0104 0.0497
Brugia malayi histone deacetylase 11 0.0266 0.0527 0.2575
Trypanosoma brucei DNA polymerase eta, putative 0.0098 0.0178 0.1229
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0038 0.0042
Brugia malayi Fli-1 protein 0.0224 0.044 0.2151
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.0965
Schistosoma mansoni hypothetical protein 0.0063 0.0104 0.0354
Echinococcus multilocularis protein patched 0.0171 0.0328 0.0386
Loa Loa (eye worm) hypothetical protein 0.0051 0.0079 0.0375
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0097
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0121 0.0224 0.0777
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0015
Brugia malayi TAR-binding protein 0.0127 0.0237 0.1154
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0187 0.0363 0.1263
Echinococcus granulosus Protein patched homolog 1 0.0171 0.0328 0.1141
Entamoeba histolytica protein kinase, putative 0.0538 0.1095 0.5365
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0146 0.017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.0387 0.1888
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0052 0.0082
Toxoplasma gondii aldo-keto reductase 0.005 0.0076 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0036 0.0117
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0004
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.002 0.0108
Echinococcus multilocularis aldo keto reductase 0.0172 0.033 0.0388
Loa Loa (eye worm) histone deacetylase 3 0.0538 0.1094 0.5366
Onchocerca volvulus 0.0152 0.029 0.5478
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0503 0.1022 0.1018
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0269 0.0258
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0255 0.0504 0.1754
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0034 0.0289
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.006 0.0281
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0067 0.0111 0.0107
Trichomonas vaginalis glutaminase, putative 0.0554 0.1128 0.5535
Leishmania major histone deacetylase, putative 0.0538 0.1094 0.7738
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0049 0.0075 0.0502
Echinococcus multilocularis 0.0067 0.0111 0.0129
Brugia malayi hypothetical protein 0.0024 0.0023 0.01
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0056 0.0254
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.002 0.0108
Brugia malayi RE40412p 0.0015 0.0005 0.001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0067 0.0111 0.0381
Loa Loa (eye worm) hypothetical protein 0.0108 0.0198 0.0962
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0012 0.0037
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0088
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.006 0.0392
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0269 0.1311
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0033
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0691 0.1413 0.6931
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0052 0.0341
Schistosoma mansoni hypothetical protein 0.0165 0.0316 0.1096
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0201 0.1393
Brugia malayi topoisomerase 0.004 0.0056 0.0264
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0036 0.0117
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0187 0.0363 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0691 0.1413 0.6928
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0328 0.1612
Loa Loa (eye worm) hypothetical protein 0.0171 0.0328 0.1602
Schistosoma mansoni hypothetical protein 0.027 0.0536 0.1866
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0633 0.1292 0.1282
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.099 0.2038 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0067 0.0111 0.0077
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.006 0.0048
Mycobacterium leprae PROBABLE HYDROLASE 0.0115 0.0213 0.033
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Loa Loa (eye worm) matrixin family protein 0.021 0.0411 0.2006
Trichomonas vaginalis set domain proteins, putative 0.024 0.0472 0.2318
Brugia malayi Carboxylesterase family protein 0.0066 0.0109 0.0525
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0172 0.033 0.1611
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0269 0.1881
Brugia malayi hypothetical protein 0.0067 0.0111 0.0535
Onchocerca volvulus 0.0134 0.0253 0.4773
Onchocerca volvulus 0.003 0.0036 0.064
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0187 0.0363 0.1773
Brugia malayi hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis aldehyde reductase 0.0122 0.0227 0.0265
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.005 0.0076 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0036 0.0165
Trichomonas vaginalis rotamase, putative 0.0032 0.004 0.0194
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0691 0.1413 0.1409
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0036 0.0117
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0691 0.1413 0.6935
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0172 0.033 0.1621
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0014 0.0057
Plasmodium falciparum importin beta, putative 0.0029 0.0033 0.0028
Schistosoma mansoni histone deacetylase hda2 0.0266 0.0527 0.1835
Brugia malayi DKFZp564C0469 protein 0.004 0.0056 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0036 0.0117
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0056 0.0367
Schistosoma mansoni ran 0.0021 0.0017 0.005
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0187 0.0363 0.0427
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0257 0.0508 0.1769
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.006 0.0015
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0042 0.006 0.0392
Echinococcus granulosus dnaJ subfamily B 0.0826 0.1696 0.5926
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0201 0.0974
Schistosoma mansoni hypothetical protein 0.0063 0.0104 0.0354
Schistosoma mansoni amine oxidase 0.0067 0.0111 0.0381
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.005 0.0321
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.0056 0.0052
Brugia malayi hypothetical protein 0.0024 0.0023 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0052 0.0341
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0159
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0015 0.0004 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.018 0.1246
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Brugia malayi 6-phosphofructokinase 0.0109 0.0201 0.0974
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0036 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Schistosoma mansoni histone deacetylase 4 5 0.0631 0.1288 0.4501
Brugia malayi angiogenesis inhibito 0.0017 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.014 0.0265 0.129
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0387 0.0779 0.0768
Toxoplasma gondii ABC1 family protein 0.0038 0.0052 0.0048
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0201 0.0234
Echinococcus multilocularis Smad4 0.0016 0.0006 0.0004
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0172 0.033 0.1611
Leishmania major DNA polymerase eta, putative 0.0098 0.0178 0.1229
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0187 0.0363 0.1263
Loa Loa (eye worm) hypothetical protein 0.007 0.0119 0.057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Echinococcus granulosus sterol regulatory element binding protein 0.0171 0.0328 0.1141
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0237 0.1154
Loa Loa (eye worm) hypothetical protein 0.0187 0.0363 0.1773
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0067 0.0111 0.0099
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Leishmania major DNA polymerase eta, putative 0.0048 0.0073 0.0487
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0036 0.0117
Toxoplasma gondii exonuclease III APE 0.0019 0.0012 0.0008
Schistosoma mansoni Smad4 0.0016 0.0006 0.0013
Schistosoma mansoni hypothetical protein 0.0165 0.0316 0.1096
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0091 0.0614
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0246 0.0486 0.0475
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0042 0.006 0.0068
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0005 0.0004
Toxoplasma gondii histone deacetylase HDAC2 0.0538 0.1094 0.109
Brugia malayi Histone deacetylase 1 0.0538 0.1094 0.5366
Onchocerca volvulus 0.0024 0.0023 0.0388
Loa Loa (eye worm) hypothetical protein 0.0452 0.0915 0.4485
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0005 0.0008
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Brugia malayi CXXC zinc finger family protein 0.0058 0.0094 0.0447
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0412 0.2012
Toxoplasma gondii histone deacetylase HDAC1 0.0631 0.1288 0.1284
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0258
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.005 0.0232
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0082
Echinococcus multilocularis histone deacetylase 0.0631 0.1288 0.1521
Loa Loa (eye worm) histone deacetylase 7A 0.0631 0.1288 0.6318
Onchocerca volvulus 0.0172 0.033 0.6253
Schistosoma mansoni glutaminase 0.0554 0.1128 0.3939
Onchocerca volvulus 0.004 0.0056 0.1023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0015 0.0004 0.0007
Onchocerca volvulus 0.0067 0.0111 0.2078
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0075 0.0502
Giardia lamblia Rab geranylgeranyltransferase 0.0187 0.0363 0.1765
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0005 0.0004
Brugia malayi phosphoinositide-dependent protein kinase I 0.0538 0.1095 0.537
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0036 0.064
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0013
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0005 0.0004
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.002 0.0021
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0164 0.0314 0.0368
Schistosoma mansoni dihydroceramide desaturase 0.0022 0.0019 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0036 0.0165
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0036 0.0165
Echinococcus granulosus geminin 0.0178 0.0344 0.1196
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.0985
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0027 0.011
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0042 0.006 0.0048
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0042 0.006 0.0392
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0187 0.0363 0.0359
Echinococcus granulosus adam 0.0039 0.0053 0.0178
Loa Loa (eye worm) Smad1 0.0016 0.0006 0.0018
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.0522 0.2553
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0056 0.0264
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Trichomonas vaginalis alcohol dehydrogenase, putative 0.005 0.0076 0.0374
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0104 0.012
Onchocerca volvulus 0.0024 0.0023 0.0388
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.3574
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0052 0.0245
Plasmodium falciparum aldehyde reductase, putative 0.005 0.0076 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0075 0.0369
Onchocerca volvulus 0.0172 0.033 0.6253
Brugia malayi Muscleblind-like protein 0.0452 0.0915 0.4485
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0046 0.0154
Brugia malayi Ets-domain containing protein 0.0074 0.0127 0.061
Entamoeba histolytica protein kinase domain containing protein 0.0275 0.0546 0.2664
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Plasmodium vivax histone deacetylase 1, putative 0.0538 0.1094 0.109
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0067 0.0111 0.0107
Leishmania major geranylgeranyltransferase, putative 0.0187 0.0363 0.2548
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0237 0.0278
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.006 0.0293
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.2372 0.4917 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.0522 0.2553
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0034 0.0146
Onchocerca volvulus 0.0042 0.006 0.1091
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0945 0.1944 0.1934
Entamoeba histolytica aldose reductase, putative 0.0172 0.033 0.1602
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0056 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0036 0.0165
Schistosoma mansoni patched 1 0.0171 0.0328 0.1141
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.004 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0036 0.0165
Toxoplasma gondii hypothetical protein 0.0257 0.0508 0.0504
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0321
Echinococcus granulosus aldo keto reductase 0.0172 0.033 0.1147
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0691 0.1413 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Schistosoma mansoni hypothetical protein 0.0083 0.0146 0.0503
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0387 0.0779 1
Echinococcus multilocularis dual specificity 0.0275 0.0546 0.0643
Loa Loa (eye worm) matrix metalloproteinase 0.0095 0.017 0.0824
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0104 0.0354
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0508 0.3574
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0036 0.0165
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.3574
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.005 0.0165
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0079 0.0074
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0004 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0182 0.0347
Schistosoma mansoni ets-related 0.0224 0.044 0.1532
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0036 0.0165
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0042 0.006 0.0097
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0034 0.003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0036 0.0165
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0055 0.005
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0201 0.0974
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Trypanosoma cruzi aldo/keto reductase, putative 0.0172 0.033 0.2313
Schistosoma mansoni thyroid hormone receptor 0.003 0.0036 0.0117
Brugia malayi Niemann-Pick C1 protein precursor 0.0398 0.0802 0.3928
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.0363 0.2548
Brugia malayi protein C24B5.3 0.0024 0.0023 0.01
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0033 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0269 0.1311
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0164 0.0314 0.109
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0171 0.0328 0.1602
Onchocerca volvulus Matrix metalloproteinase homolog 0.021 0.0411 0.7788
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0027 0.0132
Brugia malayi Protein kinase domain containing protein 0.0049 0.0075 0.0357
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0012 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0052 0.0175
Brugia malayi jmjC domain containing protein 0.0059 0.0096 0.0459
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0146 0.0503
Brugia malayi Matrixin family protein 0.0095 0.017 0.0824
Brugia malayi AMP-binding enzyme family protein 0.0042 0.006 0.0281
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0254 0.0501 0.1745
Schistosoma mansoni rotamase 0.0033 0.0041 0.0135
Brugia malayi RNA binding protein 0.0127 0.0237 0.1154
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0075 0.0086
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.0124 0.0598
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0201 0.1393
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Brugia malayi hypothetical protein 0.0033 0.0041 0.019
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0187 0.0363 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0036 0.0165
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0006 0.0018
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0021 0.012
Loa Loa (eye worm) hypothetical protein 0.0098 0.0178 0.086
Schistosoma mansoni hypothetical protein 0.0023 0.002 0.0062
Toxoplasma gondii histone deacetylase HDAC3 0.0538 0.1094 0.109
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0103 0.0493
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0036 0.0165
Onchocerca volvulus 0.0024 0.0023 0.0388
Giardia lamblia Aldose reductase 0.0172 0.033 0.1602
Brugia malayi hypothetical protein 0.0051 0.0079 0.0375
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Plasmodium vivax SET domain protein, putative 0.0031 0.0038 0.0033
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0056 0.0276
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0182 0.0347
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0187 0.0363 0.1773
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0042 0.006 0.0048
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0268 0.0931
Loa Loa (eye worm) hypothetical protein 0.0121 0.0226 0.1096
Loa Loa (eye worm) reprolysin 0.0022 0.0019 0.0081
Brugia malayi NADH-dependent xylose reductase 0.005 0.0076 0.0362
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0691 0.1413 0.1409
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Echinococcus granulosus aldehyde reductase 0.0122 0.0227 0.0785
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0094 0.0447
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0014 0.0041
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0004 0.001
Schistosoma mansoni aldo-keto reductase 0.0172 0.033 0.1147
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0015 0.0004 0.0007
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0075 0.0086
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0022
Brugia malayi RNA, U transporter 1 0.0082 0.0144 0.0693
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0182 0.0347
Schistosoma mansoni hypothetical protein 0.0165 0.0316 0.1096
Leishmania major histone deacetylase, putative 0.0631 0.1288 0.9114
Onchocerca volvulus 0.0024 0.0023 0.0388
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Trypanosoma cruzi UDP-galactopyranose mutase 0.0067 0.0111 0.0759
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0067 0.0111 0.0381
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.006 0.0293
Trypanosoma brucei histone deacetylase 1 0.0538 0.1094 0.7738
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0034 0.003
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.005 0.0076 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0075 0.0369
Entamoeba histolytica Ran family GTPase 0.0021 0.0017 0.0061
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Brugia malayi amine oxidase, flavin-containing family protein 0.0067 0.0111 0.0535
Trichomonas vaginalis ran, putative 0.0021 0.0017 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Schistosoma mansoni nuclear hormone receptor 0.003 0.0036 0.0117
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0246 0.0486 0.0892
Echinococcus granulosus GPCR family 2 0.0063 0.0104 0.0354
Echinococcus multilocularis geminin 0.0178 0.0344 0.0404
Mycobacterium ulcerans hypothetical protein 0.005 0.0076 0.0064
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Plasmodium vivax histone deacetylase, putative 0.0631 0.1288 0.1284
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0691 0.1413 0.1409
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Onchocerca volvulus Protein patched homolog 0.0024 0.0023 0.0388
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0691 0.1413 0.6931
Loa Loa (eye worm) hypothetical protein 0.0121 0.0226 0.1096
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0201 0.0694
Plasmodium vivax aldehyde reductase, putative 0.005 0.0076 0.0072
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0005 0.001
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0257 0.0508 0.1769
Echinococcus granulosus smad 0.0016 0.0006 0.0013
Plasmodium falciparum histone deacetylase, putative 0.0631 0.1288 0.1284
Echinococcus granulosus Niemann Pick C1 protein 0.0398 0.0802 0.2798
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0036 0.0165
Entamoeba histolytica hypothetical protein 0.0275 0.0546 0.2664
Leishmania major importin beta-1 subunit, putative 0.0023 0.0021 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0056 0.0367
Trypanosoma cruzi histone deacetylase, putative 0.0266 0.0527 0.3707
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0269 0.1881
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0691 0.1413 0.6935
Echinococcus granulosus cpg binding protein 0.0061 0.01 0.0343
Echinococcus granulosus expressed protein 0.0033 0.0041 0.0135
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0014 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0036 0.004
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0277 0.1347
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0012 0.0033
Brugia malayi protein C24B5.3 0.0024 0.0023 0.01
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0079 0.0138 0.0257
Echinococcus multilocularis disintegrin and metalloproteinase 0.0022 0.0019 0.0019
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0146 0.0503
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0052 0.004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Schistosoma mansoni hypothetical protein 0.0083 0.0146 0.0503
Brugia malayi Protein kinase domain containing protein 0.0275 0.0546 0.2671
Echinococcus multilocularis Immunoglobulin 0.0015 0.0005 0.0003
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0005 0.0001
Echinococcus granulosus muscleblind protein 0.0452 0.0915 0.3195
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0075 0.0348
Schistosoma mansoni hypothetical protein 0.0063 0.0104 0.0354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0006 0.0013
Toxoplasma gondii patched family protein 0.0024 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Schistosoma mansoni hypothetical protein 0.0308 0.0614 0.2142
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0005 0.0011
Schistosoma mansoni amine oxidase 0.0067 0.0111 0.0381
Brugia malayi AMP-binding enzyme family protein 0.0042 0.006 0.0281
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.018 0.0168
Entamoeba histolytica protein kinase, putative 0.0275 0.0546 0.2664
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0257 0.0508 0.2484
Onchocerca volvulus 0.0015 0.0005 0.004
Echinococcus multilocularis histone deacetylase 8 0.0266 0.0527 0.062
Onchocerca volvulus 0.0024 0.0023 0.0388
Toxoplasma gondii patched family protein 0.0024 0.0023 0.0018
Echinococcus granulosus hypothetical protein 0.0172 0.033 0.1147
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0387 0.0779 1
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.002 0.0015
Schistosoma mansoni hypothetical protein 0.0178 0.0344 0.1196
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0331 0.0663 0.3247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0036 0.0165
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0005 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0104 0.012
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0358
Schistosoma mansoni thyroid hormone receptor 0.003 0.0036 0.0117
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0095 0.017 0.0587
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0538 0.1095 0.5376
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0027 0.011
Trypanosoma cruzi lanosterol synthase, putative 0.0187 0.0363 0.2548
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0027 0.0022
Trypanosoma brucei unspecified product 0.005 0.0077 0.0516
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0036 0.064
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0006 0.0013
Brugia malayi SWIRM domain containing protein 0.0067 0.0111 0.0535
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0042 0.006 0.0048
Echinococcus multilocularis tumor protein p63 0.0671 0.1371 0.1619
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0172 0.033 0.1621
Giardia lamblia DNA damage repair protein 0.0023 0.002 0.0075
Brugia malayi hypothetical protein 0.0024 0.0023 0.01
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.0281
Schistosoma mansoni pol-related 0.0172 0.033 0.1147
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0005 0.001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0096 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0268 0.0314
Loa Loa (eye worm) histone deacetylase 0.0631 0.1288 0.6318
Loa Loa (eye worm) RNA binding protein 0.0127 0.0237 0.1154
Echinococcus multilocularis conserved hypothetical protein 0.0015 0.0005 0.0002
Giardia lamblia Prenyltransferase 0.0691 0.1413 0.6928
Echinococcus multilocularis roundabout 2 0.0015 0.0005 0.0003
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0022 0.0019 0.0057
Toxoplasma gondii histone deacetylase HDAC5 0.0266 0.0527 0.0522
Loa Loa (eye worm) beta-lactamase 0.0038 0.0052 0.0245
Loa Loa (eye worm) matrixin family protein 0.0229 0.045 0.22
Loa Loa (eye worm) hypothetical protein 0.0268 0.0532 0.26
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0277 0.096
Echinococcus multilocularis dna polymerase eta 0.0098 0.0178 0.0207
Schistosoma mansoni histone deacetylase 1 2 3 0.0266 0.0527 0.1835
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0036 0.004
Trypanosoma brucei histone deacetylase 2 0.0266 0.0527 0.3707
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0052 0.0175
Leishmania major histone deacetylase, putative 0.0538 0.1094 0.7738
Brugia malayi Hemopexin family protein 0.0134 0.0253 0.1229
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0104 0.0497
Loa Loa (eye worm) hypothetical protein 0.0095 0.017 0.0824
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.099 0.2038 1
Brugia malayi Matrixin family protein 0.0095 0.017 0.0824
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.004 0.0249
Echinococcus multilocularis dna polymerase kappa 0.0099 0.018 0.021
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0073 0.0069
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0201 0.0694
Schistosoma mansoni hypothetical protein 0.0136 0.0256 0.0886
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0052 0.0082
Echinococcus granulosus microtubule associated protein 2 0.1385 0.2859 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0945 0.1944 0.1934
Loa Loa (eye worm) hypothetical protein 0.0209 0.0409 0.1995
Brugia malayi hypothetical protein 0.0121 0.0226 0.1096
Brugia malayi jmjC domain containing protein 0.0062 0.0103 0.0493
Schistosoma mansoni cpg binding protein 0.0058 0.0094 0.0319
Echinococcus granulosus histone deacetylase 0.0631 0.1288 0.4501
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0049 0.0075 0.0071
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Leishmania major UDP-galactopyranose mutase 0.0067 0.0111 0.0759
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0005 0.0011
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.002 0.0108
Echinococcus multilocularis histone deacetylase 6 0.0643 0.1314 0.1551
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0691 0.1413 0.6935
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Brugia malayi Patched related family protein 10 0.0024 0.0023 0.01
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0062 0.0304
Trypanosoma brucei histone deacetylase, putative 0.0631 0.1288 0.9114
Brugia malayi Patched related family protein 4 0.0024 0.0023 0.01
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0142 0.0269 0.0258
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.407 0.8458 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0014 0.0069
Giardia lamblia Replication factor C, subunit 1 0.004 0.0056 0.0254
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0187 0.0363 0.2548
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0015
Entamoeba histolytica alcohol dehydrogenase, putative 0.005 0.0076 0.0353
Trypanosoma cruzi protein farnesyltransferase, putative 0.0691 0.1413 1
Brugia malayi hypothetical protein 0.0016 0.0006 0.0018
Brugia malayi hypothetical protein 0.004 0.0056 0.0264
Mycobacterium ulcerans hydrolase 0.0115 0.0213 0.0201
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0103 0.0351
Trypanosoma brucei aldo-keto reductase, putative 0.0172 0.033 0.2313
Brugia malayi nuclear receptor RXR 0.0016 0.0006 0.0018
Echinococcus granulosus nibrin 0.004 0.0056 0.0188
Trypanosoma brucei prostaglandin f synthase 0.0172 0.033 0.2313
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0096 0.0111
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.0985
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.0281
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.0056 0.0575
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0246 0.0486 0.0967
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Schistosoma mansoni microtubule-associated protein tau 0.1385 0.2859 1
Mycobacterium ulcerans hypothetical protein 0.0142 0.0269 0.0258
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0052 0.0082
Schistosoma mansoni hypothetical protein 0.0063 0.0104 0.0354
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Brugia malayi Matrixin family protein 0.0095 0.017 0.0824
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.099 0.2038 0.7123
Trichomonas vaginalis AGC family protein kinase 0.0538 0.1095 0.5376
Onchocerca volvulus 0.0172 0.033 0.6253
Echinococcus granulosus voltage gated potassium channel subunit 0.005 0.0076 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Schistosoma mansoni hypothetical protein 0.0178 0.0344 0.1196
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0109 0.0126
Brugia malayi Histone deacetylase family protein 0.0631 0.1288 0.6318
Loa Loa (eye worm) hypothetical protein 0.0098 0.0177 0.0859
Brugia malayi 6-phosphofructokinase 0.0109 0.0201 0.0974
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0099 0.018 0.0883
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.007
Schistosoma mansoni smad 0.0016 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Onchocerca volvulus 0.0024 0.0023 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0018
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0004 0.0007
Echinococcus multilocularis dnaJ subfamily B 0.0826 0.1696 0.2002
Loa Loa (eye worm) oxidoreductase 0.0042 0.006 0.0281
Echinococcus granulosus histone deacetylase 8 0.0266 0.0527 0.1835
Schistosoma mansoni alkaline phosphatase 0.0164 0.0314 0.109
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0036 0.004
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis protoporphyrinogen oxidase 0.0067 0.0111 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0091 0.0614
Giardia lamblia Rab geranylgeranyltransferase 0.099 0.2038 1
Loa Loa (eye worm) hypothetical protein 0.0266 0.0527 0.2575
Loa Loa (eye worm) hypothetical protein 0.0142 0.0269 0.1311
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0256 0.1244
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0079 0.0527
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0633 0.1292 0.1263
Onchocerca volvulus 0.0142 0.0269 0.5092
Onchocerca volvulus Histone deacetylase 10 homolog 0.0266 0.0527 1
Onchocerca volvulus 0.024 0.0472 0.8962
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0075 0.0502
Schistosoma mansoni cell adhesion molecule 0.0015 0.0005 0.0008
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0257 0.0508 0.0598
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0067 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0352 0.173
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.018 0.0168
Echinococcus granulosus intestinal type alkaline phosphatase 0.0164 0.0314 0.109
Entamoeba histolytica aldose reductase, putative 0.0172 0.033 0.1602
Onchocerca volvulus Matrilysin homolog 0.0095 0.017 0.3198
Brugia malayi nuclear receptor NHR-88 0.003 0.0036 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0036 0.0117
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0269 0.0258
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.005 0.0056
Brugia malayi histone deacetylase 1 (HD1) 0.0538 0.1094 0.5366
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.005 0.0244
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0005 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0079 0.0074
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0008 0.0025
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0052 0.004
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0187 0.0363 0.0359
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0046 0.0154
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0075 0.0254
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0056 0.0276
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.099 0.2038 1
Echinococcus multilocularis microtubule associated protein 2 0.1385 0.2859 0.3379
Brugia malayi Histone deacetylase family protein 0.0631 0.1288 0.6318
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0111 0.0203
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0691 0.1413 0.1668
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0109 0.0126
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0004 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0088
Schistosoma mansoni gabp alpha 0.0074 0.0127 0.0434
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.018 0.1246
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0036 0.0165
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.0105
Mycobacterium ulcerans beta-lactamase 0.0038 0.0052 0.004
Schistosoma mansoni cpg binding protein 0.0061 0.01 0.0343
Trypanosoma cruzi protein farnesyltransferase, putative 0.0691 0.1413 1
Trypanosoma brucei histone deacetylase 4 0.0631 0.1288 0.9114
Trypanosoma brucei DNA polymerase IV, putative 0.0093 0.0166 0.1148
Giardia lamblia DINP protein human, muc B family 0.0079 0.0138 0.0657
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0127 0.0147
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0055 0.0246
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.005 0.0165
Echinococcus granulosus disintegrin and metalloproteinase 0.0022 0.0019 0.0057
Plasmodium vivax histone deacetylase, putative 0.0266 0.0527 0.0522
Loa Loa (eye worm) hypothetical protein 0.0136 0.0256 0.1244
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.2493
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Schistosoma mansoni nephrin 0.0015 0.0005 0.0008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0142 0.0269 0.0258
Echinococcus granulosus histone deacetylase 6 0.0643 0.1314 0.459
Loa Loa (eye worm) hypothetical protein 0.0083 0.0146 0.0707
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0052 0.0059
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0012 0.0047
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0004 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0124
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0014 0.001
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0034 0.003
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0042 0.006 0.0048
Brugia malayi RE40412p 0.0015 0.0005 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0269 0.1311
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0187 0.0363 0.1783
Onchocerca volvulus 0.0108 0.0198 0.3737
Echinococcus granulosus neuroglian 0.0015 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0022
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0108 0.0198 0.0962
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.004 0.0056 0.0008
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0014 0.0069
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0014 0.0057
Schistosoma mansoni histone deacetylase 4 5 0.0631 0.1288 0.4501
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0036 0.0117
Echinococcus multilocularis GPCR, family 2 0.0063 0.0104 0.012
Brugia malayi ADAM-TS Spacer 1 family protein 0.0017 0.0007 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.0105
Mycobacterium tuberculosis Possible oxidoreductase 0.0067 0.0111 0.0203
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0734 0.1502 0.7373
Brugia malayi Patched protein homolog 1 0.0024 0.0023 0.01
Mycobacterium ulcerans dehydrogenase 0.0067 0.0111 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.002 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0268 0.0931
Plasmodium vivax geranylgeranyltransferase, putative 0.0187 0.0363 0.0359
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Trypanosoma cruzi histone deacetylase, putative 0.0631 0.1288 0.9114
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Echinococcus multilocularis bloom syndrome protein 0.002 0.0014 0.0014
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0004 0.001
Schistosoma mansoni alkaline phosphatase 0.0164 0.0314 0.109
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0005 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0036 0.0165
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Brugia malayi nuclear hormone receptor 0.003 0.0036 0.0165
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0538 0.1095 0.3825
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.002 0.0108
Echinococcus multilocularis protein dispatched 1 0.0195 0.0379 0.0445
Trypanosoma brucei cdc2-related kinase 1 0.0049 0.0075 0.0502
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.099 0.2038 0.2034
Trichomonas vaginalis aldo-keto reductase, putative 0.005 0.0076 0.0374
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.002 0.0108
Entamoeba histolytica protein kinase, putative 0.0275 0.0546 0.2664
Brugia malayi steroid hormone receptor 0.003 0.0036 0.0165
Echinococcus granulosus Smad4 0.0016 0.0006 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0036 0.0165
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0075 0.0357
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.005 0.0076 0.0072
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0018
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0368 0.0741 0.0873
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0027 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0036 0.0117
Loa Loa (eye worm) hypothetical protein 0.0187 0.0363 0.1773
Echinococcus granulosus aldo keto reductase family 1, member B4 0.005 0.0076 0.0258
Schistosoma mansoni hypothetical protein 0.0035 0.0046 0.0154
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0036 0.0117
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.0467 0.2281
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0691 0.1413 0.4937
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0042 0.006 0.0048
Plasmodium falciparum histone deacetylase 1 0.0538 0.1094 0.109
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0056 0.0264
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0142 0.0269 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0042 0.006 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Trichomonas vaginalis rotamase, putative 0.0033 0.0041 0.0202
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0006 0.0018
Echinococcus multilocularis expressed conserved protein 0.0374 0.0752 0.0886
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0042 0.006 0.0097
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trypanosoma cruzi histone deacetylase 1, putative 0.0538 0.1094 0.7738
Brugia malayi hypothetical protein 0.004 0.0056 0.0264
Echinococcus multilocularis cpg binding protein 0.0061 0.01 0.0116
Loa Loa (eye worm) hypothetical protein 0.0066 0.0109 0.0525
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0042 0.006 0.0281
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0206
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0033 0.0029
Giardia lamblia Aldose reductase 0.0172 0.033 0.1602
Trichomonas vaginalis aldo/keto reductase, putative 0.0172 0.033 0.1621
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Brugia malayi hypothetical protein 0.0015 0.0005 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0052 0.0258
Echinococcus multilocularis muscleblind protein 1 0.0452 0.0915 0.1079
Echinococcus granulosus roundabout 2 0.0015 0.0005 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0036 0.0117
Onchocerca volvulus 0.0172 0.033 0.6253
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0022 0.0019 0.0057
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0691 0.1413 0.4937
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0538 0.1094 0.5372
Mycobacterium leprae Conserved hypothetical protein 0.0122 0.0227 0.0358
Echinococcus granulosus importin subunit beta 1 0.0029 0.0033 0.0106
Trypanosoma cruzi histone deacetylase, putative 0.0631 0.1288 0.9114
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Trypanosoma brucei unspecified product 0.0093 0.0166 0.1148
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0015
Schistosoma mansoni potassium channel beta 0.005 0.0076 0.0258
Trichomonas vaginalis AGC family protein kinase 0.0538 0.1095 0.5376
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0344 0.0691 0.0814
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0004 0.001
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Echinococcus granulosus histone deacetylase 6 0.0631 0.1288 0.4501
Onchocerca volvulus 0.0042 0.006 0.1091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0508 0.3574
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Onchocerca volvulus 0.0098 0.0177 0.3335
Entamoeba histolytica recQ family helicase, putative 0.002 0.0014 0.0048
Brugia malayi beta-lactamase family protein 0.0038 0.0052 0.0245
Trypanosoma brucei lanosterol synthase 0.0187 0.0363 0.2548
Echinococcus granulosus phd:f box containing protein 0.0016 0.0005 0.001
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0063 0.0104 0.05
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.002 0.0062
Schistosoma mansoni hypothetical protein 0.0083 0.0146 0.0503
Leishmania major prostaglandin f synthase, putative 0.0172 0.033 0.2313
Loa Loa (eye worm) hypothetical protein 0.0037 0.005 0.0232
Echinococcus multilocularis adam 0.0039 0.0053 0.006
Loa Loa (eye worm) histone deacetylase 1 0.0538 0.1094 0.5366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0036 0.0165
Entamoeba histolytica alcohol dehydrogenase, putative 0.005 0.0076 0.0353
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0187 0.0363 0.0359
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0005 0.001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0067 0.0111 0.0381
Brugia malayi phosphofructokinase 0.0109 0.0201 0.0974
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0039 0.0053 0.0178
Echinococcus multilocularis voltage gated potassium channel subunit 0.005 0.0076 0.0087
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0187 0.0363 0.1783
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0254 0.0501 0.1745
Schistosoma mansoni acetyl-CoA synthetase 0.0042 0.006 0.02
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Mycobacterium ulcerans oxidoreductase 0.0067 0.0111 0.0099
Leishmania major hypothetical protein, conserved 0.0038 0.0052 0.0341
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0269 0.0446
Plasmodium vivax importin-beta 2, putative 0.0029 0.0033 0.0028
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0097
Trypanosoma brucei cdc2-related kinase 3 0.0049 0.0075 0.0502
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.0483 0.096
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.0387 0.1888
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0073 0.0124 0.0598
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0038 0.0033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.0387 0.1888
Schistosoma mansoni hypothetical protein 0.0134 0.0253 0.0876
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0404 0.0815 0.2843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0061
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0042 0.006 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0052 0.0341
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0056 0.0188
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) fli-1 protein 0.0224 0.044 0.2151
Toxoplasma gondii propionate-CoA ligase 0.0042 0.006 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.018 0.1246
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0201 0.1393
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0201 0.0974
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0036 0.004
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0036 0.0117
Brugia malayi Disintegrin family protein 0.0022 0.0019 0.0081
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0005 0.0001
Plasmodium falciparum flap endonuclease 1 0.0026 0.0027 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0018
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0056 0.0052
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0041 0.0202
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0096 0.0327
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0036 0.0165
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0006 0.0004
Mycobacterium tuberculosis Conserved protein 0.005 0.0076 0.0131
Echinococcus multilocularis sterol regulatory element binding protein 0.0171 0.0328 0.0386
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0014 0.007
Loa Loa (eye worm) hypothetical protein 0.0261 0.0517 0.2528
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0633 0.1292 0.2549
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0067 0.0111 0.0121
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0142 0.0269 0.0258
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0164 0.0314 0.109
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0033 0.0106
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0075 0.0254
Schistosoma mansoni serine/threonine protein kinase 0.0538 0.1095 0.3825
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0022 0.0019 0.0019
Echinococcus granulosus acetylcholinesterase 0.0066 0.0109 0.0374
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0021 0.0105
Schistosoma mansoni hypothetical protein 0.0826 0.1696 0.5926
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0201 0.246
Loa Loa (eye worm) hypothetical protein 0.0268 0.0532 0.26
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0257 0.0508 0.0504
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0538 0.1095 0.537
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0027 0.0029
Schistosoma mansoni flap endonuclease-1 0.0024 0.0022 0.0067
Onchocerca volvulus 0.0038 0.0052 0.0953
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0034 0.003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0036 0.0165
Brugia malayi hypothetical protein 0.0035 0.0046 0.0216
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0172 0.033 0.1611
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0062 0.0208
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0055 0.0246
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0633 0.1292 0.1289
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0012 0.0054
Trypanosoma brucei histone deacetylase 3 0.0631 0.1288 0.9114
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0269 0.1881
Trichomonas vaginalis aldo-keto reductase, putative 0.005 0.0076 0.0374
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0103 0.0351
Echinococcus granulosus flap endonuclease 1 0.0026 0.0027 0.0085
Plasmodium vivax patched family protein, putative 0.0024 0.0023 0.0018
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0109 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0075 0.0254
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0038 0.0124
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Brugia malayi beta-lactamase family protein 0.0038 0.0052 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0268 0.0931
Loa Loa (eye worm) glutaminase 2 0.0554 0.1128 0.5529
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0027 0.012
Trypanosoma cruzi lanosterol synthase, putative 0.0187 0.0363 0.2548
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.3574
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0275 0.0546 0.3845
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0005 0.0003
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0257 0.0508 0.2476
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.078 0.1599 0.5589
Echinococcus granulosus tumor protein p63 0.0671 0.1371 0.4791
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0052 0.0082
Mycobacterium ulcerans hypothetical protein 0.0038 0.0052 0.004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0152 0.029 0.1411
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Loa Loa (eye worm) histone deacetylase 11 0.0266 0.0527 0.2575
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0012 0.0054
Leishmania major DNA polymerase kappa, putative 0.0023 0.002 0.0108
Schistosoma mansoni 3-dehydroquinate synthase 0.0246 0.0486 0.1694
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Loa Loa (eye worm) acetyltransferase 0.0146 0.0277 0.1347
Schistosoma mansoni DNA helicase recq5 0.002 0.0014 0.0041
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0036 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.0985
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Onchocerca volvulus 0.0257 0.0508 0.9644
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0258
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0017 0.005
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0015
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Plasmodium falciparum histone deacetylase 2 0.0631 0.1288 0.1284
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Echinococcus multilocularis histone deacetylase 6 0.0631 0.1288 0.1521
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.005 0.0244
Plasmodium vivax JmjC domain containing protein 0.0016 0.0005 0.0001
Echinococcus granulosus defective proboscis extension response 0.0015 0.0005 0.0008
Toxoplasma gondii chorismate synthase, putative 0.4809 1 1
Echinococcus granulosus alkaline phosphatase 0.0164 0.0314 0.109
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0005 0.0004
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0075 0.0348
Loa Loa (eye worm) hypothetical protein 0.0095 0.017 0.0824
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0187 0.0363 0.1765
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0022
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0075 0.0357
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0082
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Brugia malayi hypothetical protein 0.0152 0.029 0.1411
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0018
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0034 0.003
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0075 0.0254
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Onchocerca volvulus Protein patched homolog 0.0024 0.0023 0.0388
Toxoplasma gondii aldose reductase, putative 0.0172 0.033 0.0326
Schistosoma mansoni terminal deoxycytidyl transferase 0.0073 0.0124 0.0426
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.099 0.2038 1
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0056 0.0052
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0036 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0056 0.0367
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0073 0.0124 0.0426
Brugia malayi ecdysteroid receptor 0.003 0.0036 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0546 0.1903
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0015
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0042 0.006 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0036 0.004
Brugia malayi Matrixin family protein 0.0095 0.017 0.0824
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0042 0.006 0.02
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Echinococcus granulosus histone deacetylase 3 0.0538 0.1094 0.3822
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0036 0.064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Brugia malayi Protein kinase domain containing protein 0.0538 0.1095 0.537
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0269 0.0446
Brugia malayi histone deacetylase 3 (HD3) 0.0538 0.1094 0.5366
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0054
Chlamydia trachomatis DNA ligase 0.004 0.0056 0.0022
Loa Loa (eye worm) hypothetical protein 0.0365 0.0734 0.3596
Brugia malayi AMP-binding enzyme family protein 0.0042 0.006 0.0281
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0212 0.0207
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0059
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0146 0.017
Echinococcus multilocularis aldo keto reductase 0.0172 0.033 0.0388
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0257 0.0508 0.3574
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.018 0.1246
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0106 0.0194 0.0161
Echinococcus multilocularis histone deacetylase 6 0.0631 0.1288 0.1521
Loa Loa (eye worm) hypothetical protein 0.0538 0.1094 0.5366
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0022 0.0019 0.0057
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.099 0.2038 0.7123
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0006 0.0004
Schistosoma mansoni topbp1 0.004 0.0056 0.0188
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0187 0.0363 0.0716
Schistosoma mansoni aldo-keto reductase 0.0172 0.033 0.1147
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0052 0.0258
Giardia lamblia Histone deacetylase 0.0538 0.1094 0.5361
Trichomonas vaginalis aldo-keto reductase, putative 0.005 0.0076 0.0374
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0062 0.0058
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0096 0.0327
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0079 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0036 0.0165
Plasmodium falciparum acyl-CoA synthetase 0.0106 0.0194 0.019
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0036 0.0165
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0368 0.0741 0.3628
Leishmania major histone deacetylase, putative 0.0631 0.1288 0.9114
Entamoeba histolytica aldose reductase, putative 0.0172 0.033 0.1602
Echinococcus granulosus aldo keto reductase 0.0172 0.033 0.1147
Echinococcus granulosus snurportin 1 0.0308 0.0614 0.2142
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0042 0.006 0.0048
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.005 0.0222

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 91 nM Inhibition of porcine TACE ChEMBL. 17188861
IC50 (binding) = 91 nM Inhibition of porcine TACE ChEMBL. 17188861
IC50 (binding) = 0.091 uM In vitro inhibitory concentration against human tumor necrosis factor-alpha converting enzyme ChEMBL. 15908214
IC50 (binding) = 0.091 uM In vitro inhibitory concentration against human tumor necrosis factor-alpha converting enzyme ChEMBL. 15908214
IC50 (binding) = 0.091 uM Inhibition of pig TACE ChEMBL. 19095454
Inhibition (binding) = 37 % In vitro percent inhibition against aggrecanase at the concentration of 1 uM ChEMBL. 15908214
Ki (binding) > 2.13 uM In vitro binding affinity against matrix metalloproteinase 9 ChEMBL. 15908214
Ki (binding) > 2.13 uM In vitro binding affinity against matrix metalloproteinase 9 ChEMBL. 15908214
Ki (binding) > 3.33 uM In vitro binding affinity against matrix metalloproteinase 2 ChEMBL. 15908214
Ki (binding) > 3.33 uM In vitro binding affinity against matrix metalloproteinase 2 ChEMBL. 15908214
Ki (binding) > 4.95 uM In vitro binding affinity against matrix metalloproteinase 1 ChEMBL. 15908214
Ki (binding) > 4.95 uM In vitro binding affinity against matrix metalloproteinase 1 ChEMBL. 15908214
Ki (binding) > 5.02 uM In vitro binding affinity against matrix metalloproteinase 13 ChEMBL. 15908214
Ki (binding) > 5.02 uM In vitro binding affinity against matrix metalloproteinase 13 ChEMBL. 15908214
pKa = 7.2 Dissociation constant, pKa of the compound in water ChEMBL. 17188861

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.