Detailed information for compound 335745

Basic information

Technical information
  • TDR Targets ID: 335745
  • Name: 5-(4-benzylpiperazin-1-yl)-5-[4-[(2-methylqui nolin-4-yl)methoxy]phenyl]-1,3-diazinane-2,4, 6-trione
  • MW: 549.62 | Formula: C32H31N5O4
  • H donors: 2 H acceptors: 4 LogP: 3.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1NC(=O)C(C(=O)N1)(N1CCN(CC1)Cc1ccccc1)c1ccc(cc1)OCc1cc(C)nc2c1cccc2
  • InChi: 1S/C32H31N5O4/c1-22-19-24(27-9-5-6-10-28(27)33-22)21-41-26-13-11-25(12-14-26)32(29(38)34-31(40)35-30(32)39)37-17-15-36(16-18-37)20-23-7-3-2-4-8-23/h2-14,19H,15-18,20-21H2,1H3,(H2,34,35,38,39,40)
  • InChiKey: WZUCVDGGDSHNQU-UHFFFAOYSA-N  

Network

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Synonyms

  • 5-(4-benzylpiperazin-1-yl)-5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]hexahydropyrimidine-2,4,6-trione
  • 5-(4-benzyl-1-piperazinyl)-5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]hexahydropyrimidine-2,4,6-trione
  • 5-(4-benzylpiperazino)-5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]barbituric acid
  • 5-[4-(benzyl)piperazin-1-yl]-5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]barbituric acid
  • 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(phenylmethyl)piperazin-1-yl]-1,3-diazinane-2,4,6-trione
  • 5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]-5-[4-(phenylmethyl)piperazin-1-yl]hexahydropyrimidine-2,4,6-trione
  • 5-[4-[(2-methyl-4-quinolyl)methoxy]phenyl]-5-[4-(phenylmethyl)-1-piperazinyl]hexahydropyrimidine-2,4,6-trione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 13 (collagenase 3) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens ADAM metallopeptidase domain 17 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma japonicum ko:K06059 a disintegrin and metalloproteinase domain 17, putative Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus Blood coagulation inhibitor Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma mansoni ADAM17 peptidase (M12 family) Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 13 (collagenase 3) 471 aa 448 aa 34.1 %
Brugia malayi Disintegrin family protein ADAM metallopeptidase domain 17 824 aa 724 aa 27.4 %
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0066 0.0109 0.0525
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0015
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0538 0.1094 0.5366
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0146 0.0707
Plasmodium falciparum importin beta, putative 0.0029 0.0033 0.0028
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.002 0.0015
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0109 0.0374
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0005 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0269 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0138 0.0948
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0172 0.033 0.2313
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0042 0.006 0.0055
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0004 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0079 0.0138 0.0948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0268 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0015 0.0005 0.0008
Onchocerca volvulus 0.0172 0.033 0.6253
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0187 0.0363 0.1773
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0452 0.0915 0.4485
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0033 0.0028
Trichomonas vaginalis aldo-keto reductase, putative 0.005 0.0076 0.0374
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0081
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Mycobacterium leprae Possible oxidoreductase 0.005 0.0076 0.0049
Brugia malayi beta-lactamase family protein 0.0038 0.0052 0.0245
Loa Loa (eye worm) acetyltransferase 0.0146 0.0277 0.1347
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0945 0.1944 0.1934
Giardia lamblia DNA damage repair protein 0.0023 0.002 0.0075
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0005 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0269 0.1881
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0633 0.1292 0.1289
Brugia malayi protein C24B5.3 0.0024 0.0023 0.01
Brugia malayi AMP-binding enzyme family protein 0.0042 0.006 0.0281
Brugia malayi hypothetical protein 0.0024 0.0023 0.01
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0691 0.1413 0.6935
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Entamoeba histolytica recQ family helicase, putative 0.002 0.0014 0.0048
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0404 0.0815 0.2843
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.005 0.0076 0.0509
Loa Loa (eye worm) histone deacetylase 3 0.0538 0.1094 0.5366
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.0124 0.0598
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0075 0.0254
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Leishmania major DNA polymerase kappa, putative 0.0079 0.0138 0.0948
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0075 0.0348
Brugia malayi hypothetical protein 0.0015 0.0005 0.0011
Onchocerca volvulus 0.0152 0.029 0.5478
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0005 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0036 0.0117
Loa Loa (eye worm) hypothetical protein 0.0268 0.0532 0.26
Echinococcus granulosus geminin 0.0178 0.0344 0.1196
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0111 0.0107
Onchocerca volvulus 0.0024 0.0023 0.0388
Echinococcus multilocularis aldo keto reductase 0.0172 0.033 0.0388
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0006 0.0013
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0691 0.1413 0.1668
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0005 0.0008
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0027 0.011
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0691 0.1413 0.4937
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Loa Loa (eye worm) hypothetical protein 0.0452 0.0915 0.4485
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.005 0.0056
Schistosoma mansoni hypothetical protein 0.0165 0.0316 0.1096
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0146 0.0503
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0042 0.006 0.0392
Trypanosoma cruzi histone deacetylase, putative 0.0631 0.1288 0.9114
Giardia lamblia Histone deacetylase 0.0538 0.1094 0.5361
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0042 0.006 0.0097
Schistosoma mansoni cell adhesion molecule 0.0015 0.0005 0.0008
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0146 0.0503
Echinococcus granulosus histone deacetylase 7 0.0631 0.1288 0.4501
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0036 0.004
Schistosoma mansoni alkaline phosphatase 0.0164 0.0314 0.109
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0017 0.0012
Echinococcus multilocularis dnaJ subfamily B 0.0826 0.1696 0.2002
Schistosoma mansoni cpg binding protein 0.0058 0.0094 0.0319
Echinococcus multilocularis histone deacetylase 0.0631 0.1288 0.1521
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0015
Onchocerca volvulus 0.0108 0.0198 0.3737
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0109 0.0126
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0246 0.0486 0.0967
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0014 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0538 0.1095 0.3825
Toxoplasma gondii hypothetical protein 0.0734 0.1502 0.1498
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0022 0.0019 0.0057
Plasmodium vivax histone deacetylase 1, putative 0.0538 0.1094 0.109
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0017 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0104 0.0354
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0036 0.004
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0187 0.0363 0.1765
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0127 0.0147
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.005 0.0222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0182 0.0347
Brugia malayi Ets-domain containing protein 0.0074 0.0127 0.061
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0187 0.0363 0.0427
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0255 0.0504 0.0593
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0014 0.001
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Entamoeba histolytica deoxycytidyl transferase, putative 0.0073 0.0124 0.0589
Schistosoma mansoni amine oxidase 0.0067 0.0111 0.0381
Mycobacterium ulcerans lipase LipD 0.0038 0.0052 0.004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Leishmania major hypothetical protein, conserved 0.0038 0.0052 0.0341
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0255 0.0504 0.1754
Echinococcus granulosus histone deacetylase 6 0.0631 0.1288 0.4501
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Trichomonas vaginalis esterase, putative 0.0038 0.0052 0.0258
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0036 0.004
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0034 0.003
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0075 0.0254
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0006 0.0013
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0005 0.0011
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0277 0.1347
Mycobacterium ulcerans hypothetical protein 0.005 0.0076 0.0064
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.0965
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0056 0.0276
Echinococcus granulosus hypothetical protein 0.0172 0.033 0.1147
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.004 0.0249
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.005 0.0244
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0027 0.012
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.099 0.2038 1
Echinococcus granulosus histone deacetylase 6 0.0643 0.1314 0.459
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0039 0.0053 0.0178
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0075 0.0369
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.002 0.0108
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0034 0.003
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0005 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0059
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0344 0.0691 0.0814
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0879 0.1805 0.3655
Trichomonas vaginalis rotamase, putative 0.0033 0.0041 0.0202
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Onchocerca volvulus 0.0042 0.006 0.1091
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0005 0.001
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.2493
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0036 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Schistosoma mansoni hypothetical protein 0.0083 0.0146 0.0503
Brugia malayi Patched related family protein 4 0.0024 0.0023 0.01
Trichomonas vaginalis AGC family protein kinase 0.0538 0.1095 0.5376
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0691 0.1413 0.1409
Brugia malayi RE40412p 0.0015 0.0005 0.001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.006 0.0281
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0201 0.0234
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0014 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Onchocerca volvulus 0.0042 0.006 0.1091
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0103 0.0351
Mycobacterium leprae Conserved hypothetical protein 0.0122 0.0227 0.0358
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0036 0.0117
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.0985
Trypanosoma brucei histone deacetylase 3 0.0631 0.1288 0.9114
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0012 0.0012
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0042 0.006 0.0097
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0201 0.1393
Loa Loa (eye worm) beta-lactamase 0.0038 0.0052 0.0245
Brugia malayi angiogenesis inhibito 0.0017 0.0007 0.0022
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0036 0.004
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.004 0.0173
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0056 0.0254
Schistosoma mansoni hypothetical protein 0.0826 0.1696 0.5926
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0004 0.001
Echinococcus multilocularis tumor protein p63 0.0671 0.1371 0.1619
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0182 0.0347
Echinococcus granulosus tar DNA binding protein 0.0127 0.0237 0.0822
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.005 0.0076 0.0072
Echinococcus multilocularis dna polymerase eta 0.0098 0.0178 0.0207
Brugia malayi Protein kinase domain containing protein 0.0275 0.0546 0.2671
Brugia malayi hypothetical protein 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0187 0.0363 0.1773
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0036 0.0165
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0075 0.0502
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0187 0.0363 0.0427
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trypanosoma brucei histone deacetylase, putative 0.0631 0.1288 0.9114
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0257 0.0508 0.1769
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0042 0.006 0.0097
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.005 0.0165
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0052 0.0175
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0269 0.0446
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0067 0.0111 0.0107
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0067 0.0111 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0036 0.0165
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.055 0.1119 0.3908
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0056 0.0052
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0018
Schistosoma mansoni histone deacetylase 4 5 0.0631 0.1288 0.4501
Schistosoma mansoni histone deacetylase 1 2 3 0.0266 0.0527 0.1835
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0146 0.0707
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0004 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0036 0.0117
Onchocerca volvulus 0.0031 0.0038 0.0674
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.006 0.0015
Onchocerca volvulus 0.0142 0.0269 0.5092
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0005 0.0004
Trypanosoma brucei prostaglandin f synthase 0.0172 0.033 0.2313
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.018 0.0168
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0015 0.0004 0.001
Echinococcus multilocularis aldo keto reductase 0.0172 0.033 0.0388
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0042 0.006 0.0281
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.004 0.0249
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0075 0.0254
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0079 0.0527
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0079 0.0527
Echinococcus multilocularis histone deacetylase 6 0.0631 0.1288 0.1521
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0004 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0036 0.0165
Trichomonas vaginalis AGC family protein kinase 0.0538 0.1095 0.5376
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0013
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0106 0.0194 0.0161
Brugia malayi histone deacetylase 1 (HD1) 0.0538 0.1094 0.5366
Chlamydia trachomatis protoporphyrinogen oxidase 0.0067 0.0111 0.0077
Brugia malayi protein C24B5.3 0.0024 0.0023 0.01
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0503 0.1022 0.1018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0036 0.0165
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0187 0.0363 0.1783
Loa Loa (eye worm) hypothetical protein 0.0063 0.0104 0.0497
Schistosoma mansoni histone deacetylase 0.0538 0.1094 0.3822
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0187 0.0363 0.2548
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.099 0.2038 0.7123
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.018 0.1246
Plasmodium falciparum chorismate synthase 0.4809 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.006 0.0293
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0148
Schistosoma mansoni cpg binding protein 0.0061 0.01 0.0343
Schistosoma mansoni histone deacetylase hda2 0.0643 0.1314 0.459
Onchocerca volvulus 0.0024 0.0023 0.0388
Loa Loa (eye worm) hypothetical protein 0.0108 0.0198 0.0962
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0097
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.004 0.0035
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0187 0.0363 0.1783
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0027 0.011
Echinococcus granulosus muscleblind protein 0.0452 0.0915 0.3195
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0352 0.173
Echinococcus granulosus cpg binding protein 0.0061 0.01 0.0343
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0014 0.0069
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0201 0.0974
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Leishmania major DNA polymerase eta, putative 0.0048 0.0073 0.0487
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0014 0.0069
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0691 0.1413 0.1409
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0036 0.0117
Schistosoma mansoni patched 1 0.0171 0.0328 0.1141
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Schistosoma mansoni hypothetical protein 0.0035 0.0046 0.0154
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0036 0.0117
Brugia malayi Protein kinase domain containing protein 0.0538 0.1095 0.537
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Leishmania major UDP-galactopyranose mutase 0.0067 0.0111 0.0759
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0275 0.0546 0.3845
Brugia malayi hypothetical protein 0.0024 0.0023 0.01
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0052 0.004
Echinococcus granulosus histone deacetylase 0.0631 0.1288 0.4501
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0015
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0042 0.006 0.0097
Onchocerca volvulus 0.0038 0.0052 0.0953
Brugia malayi Pre-SET motif family protein 0.0211 0.0412 0.2012
Echinococcus granulosus lysine specific histone demethylase 1A 0.0067 0.0111 0.0381
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.002 0.0108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Brugia malayi Patched protein homolog 1 0.0024 0.0023 0.01
Brugia malayi AMP-binding enzyme family protein 0.0042 0.006 0.0281
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0056 0.0367
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0246 0.0486 0.0475
Onchocerca volvulus Matrilysin homolog 0.0095 0.017 0.3198
Brugia malayi hypothetical protein 0.0152 0.029 0.1411
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Leishmania major geranylgeranyltransferase, putative 0.0187 0.0363 0.2548
Loa Loa (eye worm) matrixin family protein 0.021 0.0411 0.2006
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.0965
Toxoplasma gondii patched family protein 0.0024 0.0023 0.0018
Entamoeba histolytica hypothetical protein 0.0275 0.0546 0.2664
Plasmodium vivax histone deacetylase, putative 0.0266 0.0527 0.0522
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Trypanosoma brucei cdc2-related kinase 1 0.0049 0.0075 0.0502
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0033 0.02
Plasmodium vivax prenyltransferase alpha subunit, putative 0.099 0.2038 0.2034
Brugia malayi Muscleblind-like protein 0.0452 0.0915 0.4485
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0164 0.0314 0.0368
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0257 0.0508 0.2484
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0187 0.0363 0.0359
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0027 0.0132
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0006 0.0013
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0187 0.0363 0.1783
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Leishmania major DNA polymerase kappa, putative 0.0023 0.002 0.0108
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0015
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0005 0.001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.006 0.0048
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trypanosoma brucei unspecified product 0.005 0.0077 0.0516
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.006 0.0281
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0015
Plasmodium vivax acyl-CoA synthetase, putative 0.0106 0.0194 0.019
Brugia malayi hypothetical protein 0.0024 0.0023 0.01
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.0115 0.0213 0.1035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0052 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0015
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0633 0.1292 0.2549
Echinococcus granulosus dna polymerase eta 0.0098 0.0178 0.0613
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0052 0.0082
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0075 0.0502
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0067 0.0111 0.0107
Brugia malayi Myosin head containing protein 0.0024 0.0023 0.01
Onchocerca volvulus Histone deacetylase 10 homolog 0.0266 0.0527 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0056 0.0367
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0056 0.0276
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0015 0.0004 0.0007
Schistosoma mansoni pol-related 0.0172 0.033 0.1147
Loa Loa (eye worm) glutaminase 2 0.0554 0.1128 0.5529
Loa Loa (eye worm) hypothetical protein 0.0095 0.017 0.0824
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0042 0.006 0.0097
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0005 0.001
Trypanosoma brucei aldo-keto reductase, putative 0.0172 0.033 0.2313
Loa Loa (eye worm) hypothetical protein 0.0266 0.0527 0.2575
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0096 0.0111
Schistosoma mansoni ran 0.0021 0.0017 0.005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0073 0.0069
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0352 0.173
Schistosoma mansoni terminal deoxycytidyl transferase 0.0073 0.0124 0.0426
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0054
Entamoeba histolytica Ran family GTPase 0.0021 0.0017 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.0363 0.2548
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0257 0.0508 0.0504
Brugia malayi RNA binding protein 0.0127 0.0237 0.1154
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Echinococcus granulosus expressed protein 0.0033 0.0041 0.0135
Onchocerca volvulus 0.0042 0.006 0.1091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0036 0.0117
Trypanosoma brucei lanosterol synthase 0.0187 0.0363 0.2548
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0075 0.0254
Brugia malayi Ets-domain containing protein 0.0074 0.0127 0.061
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0062 0.0058
Brugia malayi hypothetical protein 0.0039 0.0053 0.025
Trypanosoma cruzi lanosterol synthase, putative 0.0187 0.0363 0.2548
Brugia malayi Pre-SET motif family protein 0.0031 0.0038 0.0174
Plasmodium falciparum aldo-keto reductase, putative 0.005 0.0076 0.0072
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0067 0.0111 0.0381
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0257 0.0508 0.3574
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.006 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0036 0.0117
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0104 0.0497
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.3574
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0036 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0091 0.0614
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Brugia malayi Hemopexin family protein 0.0134 0.0253 0.1229
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0004
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.002 0.0108
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0005 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0036 0.0117
Plasmodium falciparum flap endonuclease 1 0.0026 0.0027 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0232 0.0802
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0142 0.0269 0.0258
Trypanosoma brucei histone deacetylase 2 0.0266 0.0527 0.3707
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0269 0.1303
Loa Loa (eye worm) hypothetical protein 0.0365 0.0734 0.3596
Brugia malayi histone deacetylase 3 (HD3) 0.0538 0.1094 0.5366
Schistosoma mansoni ran 0.0021 0.0017 0.005
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0014 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0052 0.0175
Echinococcus granulosus aldehyde reductase 0.0122 0.0227 0.0785
Trypanosoma cruzi histone deacetylase, putative 0.0266 0.0527 0.3707
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0201 0.246
Leishmania major aldo-keto reductase-like protein 0.0172 0.033 0.2313
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Echinococcus granulosus acetylcholinesterase 0.0066 0.0109 0.0374
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.002 0.0108
Mycobacterium ulcerans chorismate synthase 0.4809 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0075 0.0086
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0201 0.0974
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0075 0.0357
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0052 0.0048
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0691 0.1413 0.4937
Entamoeba histolytica protein kinase, putative 0.0538 0.1095 0.5365
Plasmodium vivax patched family protein, putative 0.0024 0.0023 0.0018
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0538 0.1095 0.537
Entamoeba histolytica protein kinase domain containing protein 0.0275 0.0546 0.2664
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.005 0.0076 0.0072
Trichomonas vaginalis aldo/keto reductase, putative 0.0172 0.033 0.1621
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0368 0.0741 0.3628
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0124 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Echinococcus granulosus alkaline phosphatase 0.0164 0.0314 0.109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0268 0.0931
Brugia malayi hypothetical protein 0.0033 0.0041 0.019
Loa Loa (eye worm) hypothetical protein 0.0142 0.0269 0.1311
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Loa Loa (eye worm) matrixin family protein 0.0229 0.045 0.22
Trichomonas vaginalis aldo/keto reductase, putative 0.0172 0.033 0.1621
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0018
Schistosoma mansoni hypothetical protein 0.027 0.0536 0.1866
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0012 0.0047
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0187 0.0363 0.2548
Toxoplasma gondii aldo-keto reductase 0.005 0.0076 0.0072
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0052 0.0245
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0538 0.1094 0.5372
Echinococcus granulosus aldo keto reductase 0.0172 0.033 0.1147
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0036 0.0165
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.004 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0049 0.0075 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0538 0.1095 0.3825
Onchocerca volvulus 0.0042 0.006 0.1091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0036 0.0165
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.005 0.0076 0.0362
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Loa Loa (eye worm) hypothetical protein 0.0098 0.0178 0.086
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0691 0.1413 0.6935
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0015 0.0004 0.0007
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0079 0.0138 0.0257
Echinococcus multilocularis 0.0067 0.0111 0.0129
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0004 0.001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.407 0.8458 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0036 0.0165
Loa Loa (eye worm) matrix metalloproteinase 0.0095 0.017 0.0824
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0096 0.0111
Leishmania major DNA polymerase eta, putative 0.0098 0.0178 0.1229
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.006 0.0055
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0007
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Brugia malayi cell division control protein 2 homolog 0.0049 0.0075 0.0357
Echinococcus multilocularis expressed conserved protein 0.0374 0.0752 0.0886
Onchocerca volvulus Protein patched homolog 0.0024 0.0023 0.0388
Echinococcus multilocularis histone deacetylase 3 0.0538 0.1094 0.1291
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0142 0.0269 0.0258
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Brugia malayi Protein kinase domain containing protein 0.0049 0.0075 0.0357
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0015 0.0004 0.0007
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0075 0.0254
Entamoeba histolytica aldose reductase, putative 0.0172 0.033 0.1602
Trichomonas vaginalis alcohol dehydrogenase, putative 0.005 0.0076 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Trichomonas vaginalis aldo-keto reductase, putative 0.005 0.0076 0.0374
Trypanosoma brucei cdc2-related kinase 3 0.0049 0.0075 0.0502
Echinococcus multilocularis dual specificity 0.0275 0.0546 0.0643
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0187 0.0363 0.0716
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.006 0.0281
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Mycobacterium ulcerans hypothetical protein 0.0023 0.002 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0006 0.0018
Echinococcus granulosus flap endonuclease 1 0.0026 0.0027 0.0085
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Leishmania major farnesyltransferase beta subunit 0.0691 0.1413 1
Echinococcus granulosus defective proboscis extension response 0.0015 0.0005 0.0008
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0042 0.006 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0036 0.0165
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.002 0.0108
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0104 0.0497
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0014 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0256 0.1244
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0073 0.0124 0.0144
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0097
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0268 0.1306
Plasmodium falciparum geranylgeranyltransferase, putative 0.0187 0.0363 0.0359
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0187 0.0363 0.0359
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0052 0.0082
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0052 0.0258
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0075 0.0086
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0206
Echinococcus granulosus aldo keto reductase family 1, member B4 0.005 0.0076 0.0258
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0075 0.0348
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus granulosus replication factor c subunit 1 0.004 0.0056 0.0188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.0387 0.1888
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.018 0.1246
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0022 0.0019 0.0057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0111 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0052 0.0341
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0103 0.0351
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0275 0.0546 0.3845
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Schistosoma mansoni microtubule-associated protein tau 0.1385 0.2859 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0056 0.0367
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0187 0.0363 0.0359
Schistosoma mansoni hypothetical protein 0.0134 0.0253 0.0876
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0034 0.003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0052 0.0059
Mycobacterium ulcerans monoamine oxidase 0.0067 0.0111 0.0099
Brugia malayi beta-lactamase family protein 0.0038 0.0052 0.0245
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0269 0.0258
Schistosoma mansoni DNA polymerase eta 0.0098 0.0178 0.0613
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.0387 0.1888
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0268 0.0931
Schistosoma mansoni hypothetical protein 0.0165 0.0316 0.1096
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0387 0.0779 0.0747
Plasmodium vivax histone deacetylase 2, putative 0.0631 0.1288 0.1284
Schistosoma mansoni hypothetical protein 0.0178 0.0344 0.1196
Onchocerca volvulus 0.0038 0.0052 0.0953
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0508 0.3574
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.099 0.2038 1
Loa Loa (eye worm) histone deacetylase 0.0631 0.1288 0.6318
Onchocerca volvulus 0.0172 0.033 0.6253
Loa Loa (eye worm) hypothetical protein 0.0152 0.029 0.1411
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0042 0.006 0.02
Treponema pallidum DNA ligase (lig) 0.004 0.0056 0.0575
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0022
Echinococcus granulosus histone deacetylase 6 0.0631 0.1288 0.4501
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0691 0.1413 0.6935
Schistosoma mansoni vesicular amine transporter 0.0015 0.0005 0.0008
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0034 0.0168
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0146 0.0503
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0005 0.0008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0034 0.0289
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0012 0.0046
Onchocerca volvulus 0.0134 0.0253 0.4773
Brugia malayi TAR-binding protein 0.0127 0.0237 0.1154
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0206
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0015
Plasmodium falciparum lipid/sterol:H+ symporter 0.0024 0.0023 0.0018
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0187 0.0363 0.1263
Brugia malayi Matrixin family protein 0.0229 0.045 0.22
Chlamydia trachomatis dehyroquinate synthase 0.0246 0.0486 0.0454
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0005 0.0003
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0434 0.0877 0.1035
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0257 0.0508 0.0598
Trypanosoma cruzi aldo/keto reductase, putative 0.0172 0.033 0.2313
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0434 0.0877 0.3063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0008 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.0985
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0012 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0036 0.0165
Schistosoma mansoni hypothetical protein 0.0063 0.0104 0.0354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0036 0.0165
Loa Loa (eye worm) hypothetical protein 0.0209 0.0409 0.1995
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0508 0.3574
Trichomonas vaginalis ran, putative 0.0021 0.0017 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Plasmodium vivax protein kinase Crk2 0.0049 0.0075 0.0071
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0387 0.0779 0.0768
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.002 0.0062
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0691 0.1413 0.6931
Plasmodium vivax aldehyde reductase, putative 0.005 0.0076 0.0072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Schistosoma mansoni importin beta-1 0.0029 0.0033 0.0106
Schistosoma mansoni potassium channel beta 0.005 0.0076 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0119 0.0114
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0056 0.0063
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.018 0.1246
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0005 0.0008
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0033
Brugia malayi MH2 domain containing protein 0.0237 0.0467 0.2281
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0056 0.0276
Trypanosoma cruzi UDP-galactopyranose mutase 0.0067 0.0111 0.0759
Schistosoma mansoni Smad4 0.0016 0.0006 0.0013
Leishmania major hypothetical protein, unknown function 0.0015 0.0005 0.0001
Giardia lamblia Prenyltransferase 0.0691 0.1413 0.6928
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0172 0.033 0.1611
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0005 0.0001
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.099 0.2038 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.0387 0.1888
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0172 0.033 0.1611
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.005 0.0321
Brugia malayi Histone deacetylase family protein 0.0631 0.1288 0.6318
Brugia malayi ImpB/MucB/SamB family protein 0.0098 0.0178 0.086
Onchocerca volvulus 0.0024 0.0023 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0091 0.0614
Brugia malayi nuclear hormone receptor 0.003 0.0036 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0036 0.0165
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0146 0.017
Mycobacterium ulcerans glutaminase 0.0554 0.1128 0.1117
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.018 0.1246
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Echinococcus granulosus sterol regulatory element binding protein 0.0171 0.0328 0.1141
Schistosoma mansoni dihydroceramide desaturase 0.0022 0.0019 0.0057
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0015
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Schistosoma mansoni 3-dehydroquinate synthase 0.0246 0.0486 0.1694
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0076 0.0374
Trypanosoma cruzi aldo/keto reductase, putative 0.005 0.0076 0.0509
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0036 0.0117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Onchocerca volvulus 0.003 0.0036 0.064
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0277 0.0324
Brugia malayi jmjC domain containing protein 0.0062 0.0103 0.0493
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0246 0.0486 0.0967
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0201 0.0305
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0012 0.0012
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.099 0.2038 0.7123
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0033 0.0029
Brugia malayi Smad1 0.0016 0.0006 0.0018
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.005 0.0076 0.0072
Mycobacterium tuberculosis Probable oxidoreductase 0.0172 0.033 0.0649
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0187 0.0363 0.1263
Echinococcus granulosus twitchin 0.0022 0.0019 0.0058
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0115 0.0213 0.1035
Plasmodium falciparum histone deacetylase, putative 0.0631 0.1288 0.1284
Toxoplasma gondii ABC1 family protein 0.0038 0.0052 0.0048
Mycobacterium ulcerans acetyl-CoA synthetase 0.0042 0.006 0.0048
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0022 0.0019 0.0019
Echinococcus multilocularis histone deacetylase 6 0.0643 0.1314 0.1551
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0398 0.0802 0.3922
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.018 0.0168
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0017 0.005
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0109 0.0126
Schistosoma mansoni rotamase 0.0033 0.0041 0.0135
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0108 0.0198 0.0962
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0062 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0052 0.0341
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.2372 0.4917 1
Entamoeba histolytica hypothetical protein 0.0023 0.0021 0.0083
Brugia malayi topoisomerase 0.004 0.0056 0.0264
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0257 0.0508 0.3574
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.3574
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0042 0.006 0.0048
Schistosoma mansoni cpg binding protein 0.0061 0.01 0.0343
Schistosoma mansoni ets-related 0.0224 0.044 0.1532
Trypanosoma cruzi lanosterol synthase, putative 0.0187 0.0363 0.2548
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0358
Onchocerca volvulus Protein patched homolog 0.0024 0.0023 0.0388
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0088
Entamoeba histolytica protein kinase, putative 0.0275 0.0546 0.2664
Mycobacterium tuberculosis Conserved protein 0.005 0.0076 0.0131
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0014 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0269 0.0258
Brugia malayi histone deacetylase 11 0.0266 0.0527 0.2575
Brugia malayi jmjC domain containing protein 0.0059 0.0096 0.0459
Leishmania major importin beta-1 subunit, putative 0.0023 0.0021 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0075 0.0369
Echinococcus multilocularis Niemann Pick C1 protein 0.0398 0.0802 0.0945
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0201 0.0694
Onchocerca volvulus 0.0098 0.0177 0.3335
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0237 0.1154
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0075 0.0357
Brugia malayi beta-lactamase 0.0038 0.0052 0.0245
Brugia malayi Matrixin family protein 0.0095 0.017 0.0824
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.005 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0269 0.1311
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0082
Brugia malayi Carboxylesterase family protein 0.0066 0.0109 0.0525
Loa Loa (eye worm) oxidoreductase 0.0042 0.006 0.0281
Loa Loa (eye worm) hypothetical protein 0.0095 0.017 0.0824
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0018
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.099 0.2038 1
Onchocerca volvulus 0.0172 0.033 0.6253
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0041 0.019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0036 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0237 0.0822
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Brugia malayi hypothetical protein 0.004 0.0056 0.0264
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0036 0.004
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0075 0.0357
Schistosoma mansoni hypothetical protein 0.0083 0.0146 0.0503
Giardia lamblia Aldose reductase 0.0172 0.033 0.1602
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0012
Plasmodium vivax chorismate synthase 0.4809 1 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.0036 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0036 0.0165
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.005 0.0222
Echinococcus granulosus voltage gated potassium channel subunit 0.005 0.0076 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.005 0.0244
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0022
Onchocerca volvulus 0.0015 0.0005 0.004
Loa Loa (eye worm) hypothetical protein 0.0037 0.005 0.0232
Loa Loa (eye worm) oxidoreductase 0.0172 0.033 0.1611
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0344 0.0691 0.2409
Echinococcus granulosus FTZ F1 alpha 0.003 0.0036 0.0117
Trichomonas vaginalis rotamase, putative 0.0032 0.004 0.0194
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0146 0.017
Onchocerca volvulus Matrix metalloproteinase homolog 0.021 0.0411 0.7788
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0127 0.0434
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0187 0.0363 0.1773
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0079 0.0074
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0034 0.003
Brugia malayi Patched related family protein 10 0.0024 0.0023 0.01
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0257 0.0508 0.2484
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.0467 0.2281
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0049 0.0075 0.0502
Onchocerca volvulus 0.0257 0.0508 0.9644
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.005 0.0165
Trichomonas vaginalis set domain proteins, putative 0.024 0.0472 0.2318
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0056 0.0264
Schistosoma mansoni histone deacetylase 0.0538 0.1094 0.3822
Echinococcus multilocularis aldo keto reductase 0.0172 0.033 0.0388
Entamoeba histolytica aldose reductase, putative 0.0172 0.033 0.1602
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.005 0.0232
Loa Loa (eye worm) hypothetical protein 0.0066 0.0109 0.0525
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0056 0.0044
Trypanosoma cruzi protein farnesyltransferase, putative 0.0691 0.1413 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0172 0.033 0.1611
Toxoplasma gondii chorismate synthase, putative 0.4809 1 1
Onchocerca volvulus 0.0024 0.0023 0.0388
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0103 0.0493
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0142 0.0269 0.0525
Echinococcus multilocularis muscleblind protein 1 0.0452 0.0915 0.1079
Schistosoma mansoni topbp1 0.004 0.0056 0.0188
Schistosoma mansoni hypothetical protein 0.0063 0.0104 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.0363 0.2548
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0067 0.0111 0.0121
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Loa Loa (eye worm) hypothetical protein 0.0268 0.0532 0.26
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0036 0.0165
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0018
Mycobacterium ulcerans oxidoreductase 0.0172 0.033 0.0319
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0097
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0005 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0269 0.1881
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0387 0.0779 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.01 0.0181 0.0625
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0329 0.066 0.23
Schistosoma mansoni flap endonuclease-1 0.0024 0.0022 0.0067
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0008 0.0025
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.002 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0091 0.0614
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Echinococcus multilocularis neuroglian 0.0015 0.0005 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0036 0.0117
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0062 0.0058
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0056 0.0276
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0036 0.004
Schistosoma mansoni hypothetical protein 0.0063 0.0104 0.0354
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.006 0.0272
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.007 0.0119 0.057
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0079 0.0074
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0033 0.0036
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.0522 0.2553
Schistosoma mansoni DNA helicase recq5 0.002 0.0014 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0005 0.0015
Onchocerca volvulus 0.0024 0.0023 0.0388
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0012 0.0034
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.3574
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.0333 0.6307
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.005 0.0244
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0056 0.0052
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0257 0.0508 0.2476
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0014 0.0014
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0201 0.0385
Loa Loa (eye worm) hypothetical protein 0.0261 0.0517 0.2528
Onchocerca volvulus 0.0095 0.017 0.3198
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0046 0.0154
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0006 0.0004
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trypanosoma cruzi aldo-keto reductase 0.0172 0.033 0.2313
Brugia malayi amine oxidase, flavin-containing family protein 0.0067 0.0111 0.0535
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0036 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0268 0.0314
Onchocerca volvulus 0.024 0.0472 0.8962
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0027 0.0022
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.004 0.0056 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0079 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.018 0.1246
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0034 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0269 0.1311
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0005 0.001
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0007
Echinococcus multilocularis Immunoglobulin 0.0015 0.0005 0.0003
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Toxoplasma gondii aldose reductase, putative 0.0172 0.033 0.0326
Trypanosoma cruzi histone deacetylase 1, putative 0.0538 0.1094 0.7738
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0067 0.0111 0.0129
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0014 0.0057
Schistosoma mansoni topbp1 0.004 0.0056 0.0188
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0096 0.0327
Echinococcus granulosus aldo keto reductase 0.0172 0.033 0.1147
Echinococcus granulosus dna polymerase kappa 0.0099 0.018 0.0621
Echinococcus multilocularis GPCR, family 2 0.0063 0.0104 0.012
Plasmodium vivax histone deacetylase, putative 0.0631 0.1288 0.1284
Echinococcus multilocularis nibrin 0.004 0.0056 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Trypanosoma brucei histone deacetylase 4 0.0631 0.1288 0.9114
Echinococcus granulosus Niemann Pick C1 protein 0.0568 0.1158 0.4044
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0237 0.1154
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0146 0.0503
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0691 0.1413 0.6935
Loa Loa (eye worm) histone deacetylase 1 0.0538 0.1094 0.5366
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0088
Loa Loa (eye worm) hypothetical protein 0.0136 0.0256 0.1244
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0945 0.1944 0.1934
Echinococcus granulosus importin subunit beta 1 0.0029 0.0033 0.0106
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0633 0.1292 0.1282
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.006 0.0097
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0013
Echinococcus granulosus smad 0.0016 0.0006 0.0013
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0056 0.0264
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0538 0.1094 0.5372
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0104 0.012
Echinococcus granulosus tumor protein p63 0.0671 0.1371 0.4791
Brugia malayi hypothetical protein 0.004 0.0056 0.0264
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0047
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0172 0.033 0.2313
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0177 0.0612
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0004 0.0002
Trichomonas vaginalis DNA polymerase eta, putative 0.0099 0.018 0.0883
Echinococcus granulosus bloom syndrome protein 0.002 0.0014 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0538 0.1095 0.5376
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0201 0.0694
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0042 0.006 0.0068
Plasmodium falciparum protoporphyrinogen oxidase 0.0067 0.0111 0.0107
Brugia malayi 6-phosphofructokinase 0.0109 0.0201 0.0974
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0013
Trypanosoma cruzi histone deacetylase, putative 0.0631 0.1288 0.9114
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0038 0.0033
Echinococcus multilocularis sterol regulatory element binding protein 0.0171 0.0328 0.0386
Schistosoma mansoni histone deacetylase 4 5 0.0631 0.1288 0.4501
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.099 0.2038 0.2407
Onchocerca volvulus 0.004 0.0056 0.1023
Schistosoma mansoni aldo-keto reductase 0.0172 0.033 0.1147
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0269 0.1881
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0036 0.0117
Entamoeba histolytica protein kinase, putative 0.0275 0.0546 0.2664
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0004 0.001
Echinococcus multilocularis microtubule associated protein 2 0.1385 0.2859 0.3379
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0004 0.0007
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0187 0.0363 0.1773
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0056 0.0367
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Onchocerca volvulus 0.0024 0.0023 0.0388
Echinococcus granulosus acetylcholinesterase 0.0066 0.0109 0.0374
Echinococcus granulosus Smad4 0.0016 0.0006 0.0013
Echinococcus granulosus histone deacetylase 1 0.0538 0.1094 0.3822
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0538 0.1095 0.1292
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0172 0.033 0.1621
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0052 0.0175
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0034 0.0146
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0012 0.0037
Schistosoma mansoni DNA ligase IV 0.004 0.0056 0.0188
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0073 0.0124 0.0426
Brugia malayi AMP-binding enzyme family protein 0.0042 0.006 0.0281
Giardia lamblia Replication factor C, subunit 1 0.004 0.0056 0.0254
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0014 0.007
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0075 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Brugia malayi Matrixin family protein 0.0095 0.017 0.0824
Echinococcus granulosus adam 17 protease 0.0802 0.1646 0.5751
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0014 0.001
Loa Loa (eye worm) hypothetical protein 0.0142 0.0269 0.1311
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0691 0.1413 0.6931
Entamoeba histolytica aldose reductase, putative 0.0172 0.033 0.1602
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0046 0.0052
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0055 0.005
Brugia malayi glutaminase DH11.1 0.0554 0.1128 0.5529
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0106 0.0194 0.0372
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0036 0.0165
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0121 0.0224 0.0777
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0062 0.0208
Trichomonas vaginalis aldo/keto reductase, putative 0.0172 0.033 0.1621
Schistosoma mansoni aldo-keto reductase 0.0172 0.033 0.1147
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0321
Toxoplasma gondii histone deacetylase HDAC4 0.0266 0.0527 0.0522
Schistosoma mansoni acetyl-CoA synthetase 0.0042 0.006 0.02
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0508 0.3574
Onchocerca volvulus 0.0067 0.0111 0.2078
Giardia lamblia DINP protein human, muc B family 0.0079 0.0138 0.0657
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0269 0.0258
Plasmodium falciparum histone deacetylase 1 0.0538 0.1094 0.109
Schistosoma mansoni thyroid hormone receptor 0.003 0.0036 0.0117
Echinococcus multilocularis Immunoglobulin 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0036 0.064
Echinococcus multilocularis snurportin 1 0.0308 0.0614 0.0724
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0398 0.0802 0.3928
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0005 0.001
Echinococcus multilocularis protein patched 0.0171 0.0328 0.0386
Loa Loa (eye worm) hypothetical protein 0.0121 0.0226 0.1096
Echinococcus granulosus adam 0.0039 0.0053 0.0178
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0038 0.0124
Echinococcus multilocularis alkaline phosphatase 0.0164 0.0314 0.0368
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0268 0.1306
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0048 0.0073
Brugia malayi nuclear receptor NHR-88 0.003 0.0036 0.0165
Schistosoma mansoni nephrin 0.0015 0.0005 0.0008
Echinococcus granulosus roundabout 2 0.0015 0.0005 0.0008
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0067 0.0111 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0052 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Brugia malayi RE40412p 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0104 0.05
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0079 0.0074
Echinococcus granulosus aldo keto reductase 0.0172 0.033 0.1147
Trichomonas vaginalis glutaminase, putative 0.0554 0.1128 0.5535
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.0105
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0012 0.0035
Onchocerca volvulus 0.0015 0.0005 0.004
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0022 0.0019 0.0057
Plasmodium falciparum aldehyde reductase, putative 0.005 0.0076 0.0072
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0331 0.0663 0.3247
Brugia malayi phosphofructokinase 0.0109 0.0201 0.0974
Mycobacterium tuberculosis Conserved protein 0.0038 0.0052 0.0082
Brugia malayi RNA, U transporter 1 0.0082 0.0144 0.0693
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0034 0.003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0104 0.0354
Leishmania major histone deacetylase, putative 0.0631 0.1288 0.9114
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0187 0.0363 0.1765
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0368 0.0741 0.0873
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.006 0.0392
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0052 0.0258
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Brugia malayi hypothetical protein 0.0121 0.0226 0.1096
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0264
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0038 0.0042
Plasmodium vivax JmjC domain containing protein 0.0016 0.0005 0.0001
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0286
Echinococcus multilocularis expressed protein 0.0033 0.0041 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0268 0.0931
Echinococcus multilocularis conserved hypothetical protein 0.0015 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0023 0.002 0.0062
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.0985
Trypanosoma cruzi histone deacetylase, putative 0.0631 0.1288 0.9114
Leishmania major GTP-binding protein, putative 0.0021 0.0017 0.0088
Schistosoma mansoni hypothetical protein 0.0165 0.0316 0.1096
Plasmodium falciparum acyl-CoA synthetase 0.0106 0.0194 0.019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0104 0.012
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0052 0.0082
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0075 0.0502
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0104 0.0497
Echinococcus multilocularis aldo keto reductase 0.0172 0.033 0.0388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0268 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0036 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Echinococcus multilocularis dna polymerase kappa 0.0099 0.018 0.021
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0538 0.1094 0.5372
Echinococcus granulosus neuroglian 0.0015 0.0005 0.0008
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Trypanosoma brucei unspecified product 0.0093 0.0166 0.1148
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0038 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0275 0.0546 0.3845
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0052 0.0245
Leishmania major hypothetical protein, conserved 0.0051 0.0079 0.0527
Brugia malayi Matrixin family protein 0.0095 0.017 0.0824
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0033 0.02
Mycobacterium leprae PROBABLE HYDROLASE 0.0115 0.0213 0.033
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0036 0.064
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.002 0.0108
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0012 0.0033
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0275 0.0546 0.3845
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0691 0.1413 0.6935
Onchocerca volvulus 0.0172 0.033 0.6253
Loa Loa (eye worm) glutaminase 0.0554 0.1128 0.5529
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0546 0.1903
Onchocerca volvulus 0.0038 0.0052 0.0953
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0036 0.0117
Trypanosoma cruzi UDP-galactopyranose mutase 0.0067 0.0111 0.0759
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0268 0.0314
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Echinococcus granulosus snurportin 1 0.0308 0.0614 0.2142
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0014 0.007
Brugia malayi AMP-binding enzyme family protein 0.0042 0.006 0.0281
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0109 0.0374
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0042 0.006 0.0097
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0005 0.0001
Trichomonas vaginalis aldo-keto reductase, putative 0.005 0.0076 0.0374
Loa Loa (eye worm) hypothetical protein 0.0083 0.0146 0.0707
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0237 0.0278
Echinococcus multilocularis Niemann Pick C1 protein 0.0568 0.1158 0.1366
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0257 0.0508 0.0504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0036 0.0165
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Echinococcus multilocularis disintegrin and metalloproteinase 0.0022 0.0019 0.0019
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0014 0.0041
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0042 0.006 0.0392
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0073 0.0124 0.0598
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0187 0.0363 0.1263
Mycobacterium ulcerans dehydrogenase 0.0067 0.0111 0.0099
Brugia malayi nuclear receptor RXR 0.0016 0.0006 0.0018
Chlamydia trachomatis DNA ligase 0.004 0.0056 0.0022
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0073 0.0487
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0109 0.0525
Echinococcus granulosus GPCR family 2 0.0063 0.0104 0.0354
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0257 0.0508 0.0598
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0008
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0172 0.033 0.1621
Onchocerca volvulus 0.0172 0.033 0.6253
Brugia malayi hypothetical protein 0.0067 0.0111 0.0535
Plasmodium vivax importin-beta 2, putative 0.0029 0.0033 0.0028
Onchocerca volvulus 0.005 0.0076 0.1406
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0182 0.0347
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0164 0.0314 0.0368
Brugia malayi 6-phosphofructokinase 0.0109 0.0201 0.0974
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0254 0.0501 0.1745
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0206
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Toxoplasma gondii histone deacetylase HDAC3 0.0538 0.1094 0.109
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0056 0.0276
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0172 0.033 0.1147
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0088
Onchocerca volvulus 0.0058 0.0094 0.1737
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0056 0.0052
Toxoplasma gondii patched family protein 0.0024 0.0023 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Leishmania major prostaglandin f synthase, putative 0.0172 0.033 0.2313
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Schistosoma mansoni coup transcription factor 0.003 0.0036 0.0117
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0005 0.0007
Brugia malayi ecdysteroid receptor 0.003 0.0036 0.0165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0038 0.0174
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0275 0.0546 0.2671
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.004 0.0249
Entamoeba histolytica alcohol dehydrogenase, putative 0.005 0.0076 0.0353
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0538 0.1095 0.537
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.005 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0036 0.0165
Toxoplasma gondii patched family protein 0.0024 0.0023 0.0018
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0109 0.0126
Echinococcus multilocularis adam 0.0039 0.0053 0.006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0013
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.0965
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0014 0.007
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Echinococcus granulosus dual specificity 0.0275 0.0546 0.1903
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0691 0.1413 0.1409
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.002 0.0108
Toxoplasma gondii histone lysine-specific demethylase 0.0067 0.0111 0.0107
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0006 0.0018
Toxoplasma gondii histone deacetylase HDAC2 0.0538 0.1094 0.109
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0056 0.0188
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Echinococcus multilocularis geminin 0.0178 0.0344 0.0404
Trypanosoma brucei DNA polymerase IV, putative 0.0093 0.0166 0.1148
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0691 0.1413 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0387 0.0779 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.0052 0.004
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.027 0.0536 0.1866
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0633 0.1292 0.1263
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0041 0.0202
Mycobacterium ulcerans oxidoreductase 0.0067 0.0111 0.0099
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0075 0.0502
Plasmodium vivax SET domain protein, putative 0.0031 0.0038 0.0033
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.002 0.0021
Echinococcus multilocularis histone deacetylase 6 0.0631 0.1288 0.1521
Giardia lamblia Rab geranylgeranyltransferase 0.0187 0.0363 0.1765
Echinococcus granulosus expressed conserved protein 0.0374 0.0752 0.2622
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0103 0.0351
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0201 0.0189
Entamoeba histolytica acyl-coA synthetase, putative 0.0142 0.0269 0.1303
Echinococcus granulosus microtubule associated protein 2 0.1385 0.2859 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0036 0.0165
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0212 0.0207
Trypanosoma cruzi DNA polymerase eta, putative 0.0098 0.0178 0.1229
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0368 0.0741 0.2584
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0067 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.0056 0.0575
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0042 0.006 0.0015
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0142 0.0269 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0328 0.1612
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0018
Echinococcus granulosus histone deacetylase 8 0.0266 0.0527 0.1835
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.005 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0187 0.0363 0.0359
Echinococcus multilocularis muscleblind protein 0.0452 0.0915 0.1079
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0258
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0268 0.093
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0614 0.3007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) histone deacetylase 7A 0.0631 0.1288 0.6318
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Loa Loa (eye worm) hypothetical protein 0.014 0.0265 0.129
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0061
Echinococcus granulosus dnaJ subfamily B 0.0826 0.1696 0.5926
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0042 0.006 0.0048
Loa Loa (eye worm) hypothetical protein 0.0121 0.0226 0.1096
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.0281
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Echinococcus multilocularis bloom syndrome protein 0.002 0.0014 0.0014
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.078 0.1599 0.5589
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Brugia malayi SWIRM domain containing protein 0.0067 0.0111 0.0535
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0042 0.006 0.0048
Schistosoma mansoni smad 0.0016 0.0006 0.0013
Toxoplasma gondii propionate-CoA ligase 0.0042 0.006 0.0055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0012 0.0011
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0172 0.033 0.1621
Echinococcus granulosus nibrin 0.004 0.0056 0.0188
Onchocerca volvulus Matrilysin homolog 0.021 0.0411 0.7788
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0075 0.0086
Echinococcus granulosus lysine specific histone demethylase 1A 0.0067 0.0111 0.0381
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0187 0.0363 0.1263
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0052 0.0082
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0172 0.033 0.0388
Leishmania major histone deacetylase, putative 0.0538 0.1094 0.7738
Mycobacterium ulcerans hydrolase 0.0115 0.0213 0.0201
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.0483 0.096
Brugia malayi DKFZp564C0469 protein 0.004 0.0056 0.0264
Loa Loa (eye worm) hypothetical protein 0.0172 0.033 0.1611
Echinococcus multilocularis aldehyde reductase 0.0122 0.0227 0.0265
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.018 0.1246
Echinococcus multilocularis roundabout 2 0.0015 0.0005 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0012 0.0037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0115 0.0213 0.041
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0005 0.0004
Toxoplasma gondii histone deacetylase HDAC1 0.0631 0.1288 0.1284
Brugia malayi Flap endonuclease-1 0.0026 0.0027 0.012
Loa Loa (eye worm) reprolysin 0.0022 0.0019 0.0081
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0036 0.0117
Echinococcus granulosus Niemann Pick C1 protein 0.0398 0.0802 0.2798
Brugia malayi ADAM-TS Spacer 1 family protein 0.0017 0.0007 0.0022
Echinococcus multilocularis histone deacetylase 8 0.0266 0.0527 0.062
Brugia malayi hypothetical protein 0.0016 0.0006 0.0018
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0691 0.1413 0.6928
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0368 0.0741 0.2584
Schistosoma mansoni amine oxidase 0.0067 0.0111 0.0381
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.099 0.2038 1
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0004 0.0007
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0006 0.0018
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0254 0.0501 0.1745
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0159
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.0522 0.2553
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.005 0.0165
Echinococcus multilocularis adam 17 protease 0.078 0.1599 0.1888
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Loa Loa (eye worm) hypothetical protein 0.0142 0.0269 0.1311
Toxoplasma gondii hypothetical protein 0.0257 0.0508 0.0504
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0096 0.0327
Leishmania major histone deacetylase, putative 0.0538 0.1094 0.7738
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0036 0.0117
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0269 0.1311
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0036 0.0165
Loa Loa (eye worm) Smad1 0.0016 0.0006 0.0018
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0734 0.1502 0.7373
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0033 0.0106
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0171 0.0328 0.1602
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0049 0.0075 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0038 0.0124
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.002 0.0015
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0075 0.0086
Schistosoma mansoni histone deacetylase hda2 0.0266 0.0527 0.1835
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0041 0.019
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0042 0.006 0.0097
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.2372 0.4917 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0378 0.076 0.3722
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0257 0.0508 0.1769
Echinococcus granulosus histone deacetylase 3 0.0538 0.1094 0.3822
Toxoplasma gondii exonuclease III APE 0.0019 0.0012 0.0008
Brugia malayi ADAMTS-like protease 0.0017 0.0007 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0014 0.001
Plasmodium vivax acetyl-CoA synthetase, putative 0.0042 0.006 0.0055
Schistosoma mansoni gabp alpha 0.0074 0.0127 0.0434
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.005 0.0165
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0258
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0308 0.0614 0.2142
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0006 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0059
Brugia malayi CXXC zinc finger family protein 0.0058 0.0094 0.0447
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0111 0.0107
Trypanosoma brucei unspecified product 0.005 0.0077 0.0516
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0164 0.0314 0.109
Trypanosoma brucei aldo/keto reductase, putative 0.005 0.0076 0.0509
Brugia malayi phosphoinositide-dependent protein kinase I 0.0538 0.1095 0.537
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0333 0.1635
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0036 0.004
Mycobacterium tuberculosis Possible oxidoreductase 0.0067 0.0111 0.0203
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Echinococcus multilocularis smad 0.0016 0.0006 0.0004
Echinococcus granulosus phd:f box containing protein 0.0016 0.0005 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0075 0.0369
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0055 0.0246
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0004 0.0022
Onchocerca volvulus 0.0024 0.0023 0.0388
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0005 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.0387 0.1888
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0269 0.1303
Entamoeba histolytica histone deacetylase, putative 0.0538 0.1094 0.5361
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0042 0.006 0.0048
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0021 0.0105
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.005 0.0321
Giardia lamblia Rab geranylgeranyltransferase 0.0257 0.0508 0.2476
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0046 0.0154
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0094 0.0447
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0036 0.004
Brugia malayi Matrixin family protein 0.0095 0.017 0.0824
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.0105
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0257 0.0508 0.3574
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.099 0.2038 0.2034
Schistosoma mansoni hypothetical protein 0.0063 0.0104 0.0354
Mycobacterium ulcerans hypothetical protein 0.0142 0.0269 0.0258
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0246 0.0486 0.0892
Echinococcus granulosus disintegrin and metalloproteinase 0.0022 0.0019 0.0057
Loa Loa (eye worm) patched family protein 0.0024 0.0023 0.01
Brugia malayi Histone deacetylase family protein 0.0631 0.1288 0.6318
Plasmodium vivax geranylgeranyltransferase, putative 0.0187 0.0363 0.0359
Brugia malayi Carboxylesterase family protein 0.0066 0.0109 0.0525
Loa Loa (eye worm) hypothetical protein 0.0171 0.0328 0.1602
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0015 0.0005 0.0008
Echinococcus granulosus conserved hypothetical protein 0.0015 0.0005 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0036 0.0117
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0055 0.0246
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.006 0.0392
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0187 0.0363 0.1773
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0062 0.0304
Loa Loa (eye worm) hypothetical protein 0.0098 0.0177 0.0859
Plasmodium falciparum histone deacetylase 2 0.0631 0.1288 0.1284
Loa Loa (eye worm) carboxylesterase 0.0066 0.0109 0.0525
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0007
Loa Loa (eye worm) histone deacetylase 11 0.0266 0.0527 0.2575
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0164 0.0314 0.0368
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0254 0.0501 0.059
Echinococcus granulosus Protein patched homolog 1 0.0171 0.0328 0.1141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0018
Entamoeba histolytica hypothetical protein 0.004 0.0056 0.0254
Leishmania major DNA damage repair protein, putative 0.0023 0.002 0.0108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0052 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0124
Brugia malayi Patched related family protein 12 0.0024 0.0023 0.01
Schistosoma mansoni hypothetical protein 0.0178 0.0344 0.1196
Brugia malayi Disintegrin family protein 0.0022 0.0019 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0006 0.0013
Schistosoma mansoni DNA helicase recq1 0.002 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Trypanosoma cruzi protein farnesyltransferase, putative 0.0691 0.1413 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0099 0.018 0.0883
Brugia malayi Importin beta-1 subunit 0.0029 0.0033 0.0148
Brugia malayi Niemann-Pick C1 protein precursor 0.0398 0.0802 0.3928
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0172 0.033 0.1611
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0142 0.0269 0.0258
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.0467 0.2281
Echinococcus granulosus intestinal type alkaline phosphatase 0.0164 0.0314 0.109
Giardia lamblia Rab geranylgeranyltransferase 0.099 0.2038 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.005 0.0076 0.0353
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) RNA binding protein 0.0127 0.0237 0.1154
Echinococcus multilocularis histone deacetylase 1 0.0538 0.1094 0.1291
Loa Loa (eye worm) hypothetical protein 0.099 0.2038 1
Toxoplasma gondii hypothetical protein 0.0024 0.0023 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0522 0.2562
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0201 0.1393
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0201 0.0694
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0005 0.0003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0106 0.0194 0.0183
Toxoplasma gondii histone deacetylase HDAC5 0.0266 0.0527 0.0522
Loa Loa (eye worm) hypothetical protein 0.0254 0.0501 0.245
Echinococcus multilocularis Smad4 0.0016 0.0006 0.0004
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0257 0.0508 0.3574
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0075 0.0504
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.0281
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Brugia malayi hypothetical protein 0.0035 0.0046 0.0216
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.002 0.006
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0036 0.0117
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0201 0.1393
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0027 0.0022
Trichomonas vaginalis aldo-keto reductase, putative 0.0172 0.033 0.1621
Loa Loa (eye worm) hypothetical protein 0.0051 0.0079 0.0375
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0237 0.1154
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0412 0.2012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0036 0.0117
Trypanosoma brucei histone deacetylase 1 0.0538 0.1094 0.7738
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0057
Schistosoma mansoni glutaminase 0.0554 0.1128 0.3939
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0056 0.0367
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0036 0.064
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.0056 0.0052
Schistosoma mansoni hypothetical protein 0.0136 0.0256 0.0886
Toxoplasma gondii patched family protein 0.0024 0.0023 0.0018
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.006 0.0392
Schistosoma mansoni alkaline phosphatase 0.0164 0.0314 0.109
Brugia malayi Patched family protein 0.0024 0.0023 0.01
Loa Loa (eye worm) RecQ helicase 0.002 0.0014 0.0057
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0079 0.0527
Mycobacterium ulcerans hypothetical protein 0.0038 0.0052 0.004
Echinococcus multilocularis voltage gated potassium channel subunit 0.005 0.0076 0.0087
Trypanosoma cruzi histone deacetylase 1, putative 0.0538 0.1094 0.7738
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0042 0.006 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0052 0.0245
Loa Loa (eye worm) hypothetical protein 0.0763 0.1562 0.7666
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0015 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0106 0.0194 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.018 0.1246
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0172 0.033 0.0571
Echinococcus granulosus Immunoglobulin 0.0015 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0168
Echinococcus multilocularis protoporphyrinogen oxidase 0.0067 0.0111 0.0129
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0042 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0095 0.017 0.0824
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Brugia malayi NADH-dependent xylose reductase 0.005 0.0076 0.0362
Echinococcus multilocularis protein dispatched 1 0.0195 0.0379 0.0445
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0691 0.1413 0.6935
Loa Loa (eye worm) fli-1 protein 0.0224 0.044 0.2151
Schistosoma mansoni hypothetical protein 0.0085 0.015 0.0516
Brugia malayi glutamate-cysteine ligase modifier subunit 0.005 0.0076 0.0362
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0027 0.0029
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0014 0.0057
Schistosoma mansoni hypothetical protein 0.0083 0.0146 0.0503
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0012 0.0054
Brugia malayi CHE-14 protein 0.0171 0.0328 0.1602
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0062 0.0304
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.002 0.0108
Echinococcus multilocularis cpg binding protein 0.0061 0.01 0.0116
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0042 0.006 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.006 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0054
Trypanosoma brucei DNA polymerase eta, putative 0.0098 0.0178 0.1229
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0052 0.004
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0005 0.001
Brugia malayi Histone deacetylase 1 0.0538 0.1094 0.5366
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.099 0.2038 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0095 0.017 0.0587
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0124
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0021 0.012
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0277 0.096
Brugia malayi jmjC domain containing protein 0.0016 0.0005 0.0015
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.007
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0182 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0075 0.0504
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0127 0.061
Brugia malayi polk-prov protein 0.0049 0.0075 0.0358
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0535
Brugia malayi hypothetical protein 0.0051 0.0079 0.0375
Brugia malayi steroid hormone receptor 0.003 0.0036 0.0165
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0075 0.0348
Schistosoma mansoni nuclear hormone receptor 0.003 0.0036 0.0117
Leishmania major histone deacetylase, putative 0.0631 0.1288 0.9114
Plasmodium falciparum protein kinase 5 0.0049 0.0075 0.0071
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0164 0.0314 0.109
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Onchocerca volvulus 0.0172 0.033 0.6253
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0034 0.003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0056 0.0276
Trichomonas vaginalis histone deacetylase, putative 0.0538 0.1094 0.5372
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.01
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.0985
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0067 0.0111 0.0099
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0075 0.0254
Brugia malayi Fli-1 protein 0.0224 0.044 0.2151
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0206
Giardia lamblia Aldose reductase 0.0172 0.033 0.1602
Trypanosoma cruzi histone deacetylase, putative 0.0266 0.0527 0.3707
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0165
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0201 0.0974
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0269 0.0446
Schistosoma mansoni hypothetical protein 0.0165 0.0316 0.1096
Echinococcus multilocularis histone deacetylase 7 0.0631 0.1288 0.1521
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.002 0.0108
Brugia malayi hypothetical protein 0.0024 0.0023 0.01
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0036 0.0165

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.195 uM In vitro inhibitory concentration against human tumor necrosis factor-alpha converting enzyme ChEMBL. 15908214
IC50 (binding) = 0.195 uM In vitro inhibitory concentration against human tumor necrosis factor-alpha converting enzyme ChEMBL. 15908214
Inhibition (binding) = 5 % In vitro percent inhibition against aggrecanase at the concentration of 1 uM ChEMBL. 15908214
Ki (binding) > 2.13 uM In vitro binding affinity against matrix metalloproteinase 9 ChEMBL. 15908214
Ki (binding) > 2.13 uM In vitro binding affinity against matrix metalloproteinase 9 ChEMBL. 15908214
Ki (binding) > 3.33 uM In vitro binding affinity against matrix metalloproteinase 2 ChEMBL. 15908214
Ki (binding) > 3.33 uM In vitro binding affinity against matrix metalloproteinase 2 ChEMBL. 15908214
Ki (binding) > 4.95 uM In vitro binding affinity against matrix metalloproteinase 1 ChEMBL. 15908214
Ki (binding) > 4.95 uM In vitro binding affinity against matrix metalloproteinase 1 ChEMBL. 15908214
Ki (binding) > 5.02 uM In vitro binding affinity against matrix metalloproteinase 13 ChEMBL. 15908214
Ki (binding) > 5.02 uM In vitro binding affinity against matrix metalloproteinase 13 ChEMBL. 15908214

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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