Detailed information for compound 40938

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.436 | Formula: C17H22FN3O6S
  • H donors: 5 H acceptors: 6 LogP: -2.54 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C(=O)NCC(=O)O)CSCc1ccc(cc1)F)CC[C@@H](C(=O)O)N
  • InChi: 1S/C17H22FN3O6S/c18-11-3-1-10(2-4-11)8-28-9-13(16(25)20-7-15(23)24)21-14(22)6-5-12(19)17(26)27/h1-4,12-13H,5-9,19H2,(H,20,25)(H,21,22)(H,23,24)(H,26,27)/t12-,13?/m0/s1
  • InChiKey: BNCZVMRBYISWMD-UEWDXFNNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0006 0.0006
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0187 0.3428
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0355
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0071 0.0303 0.6123
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.001 0.0017 0.0353
Leishmania major pteridine reductase 1 0.0008 0.0006 0.0116
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0132 0.0452
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0072 0.017
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.012 0.0535 0.0535
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0008 0.0006 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0087 0.1585
Toxoplasma gondii sugar transporter ST1 0.001 0.0017 0.032
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0006 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0187 0.378
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0018 0.0018
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0395 0.0395
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Echinococcus multilocularis lamin 0.0029 0.0104 0.0104
Onchocerca volvulus 0.0008 0.0006 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0018 0.0018
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0187 0.3428
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0006 0.0128
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0006 0.0116
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0006 0.0015
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0028 0.0095
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0008 0.0006 0.0031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0006 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0395 0.0395
Onchocerca volvulus 0.001 0.0017 0.0052
Schistosoma mansoni carbonyl reductase 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0029 0.0107 0.0322
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Giardia lamblia Sugar-proton symporter 0.001 0.0017 0.0041
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0011 0.0037
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0454 0.9179
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0008 0.0006 0.0031
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0546 0.0546
Mycobacterium ulcerans dehydrogenase 0.0008 0.0006 0.0031
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0187 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0017 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.011 0.0262
Echinococcus multilocularis oxidoreductase 0.0008 0.0006 0.0006
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0006 0.0031
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0006 0.0116
Leishmania major hypothetical protein, conserved 0.0008 0.0006 0.0116
Brugia malayi Cytochrome P450 family protein 0.0013 0.0028 0.0095
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Brugia malayi Sugar transporter family protein 0.001 0.0017 0.006
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0006 0.0006
Brugia malayi hypothetical protein 0.0008 0.0006 0.0022
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0028 0.0136
Mycobacterium ulcerans short-chain type oxidoreductase 0.0008 0.0006 0.0031
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.0495 0.1173
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0187 0.0444
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.0353
Schistosoma mansoni lamin 0.0029 0.0104 0.0104
Toxoplasma gondii 6-phosphofructokinase 0.003 0.011 0.2025
Mycobacterium ulcerans oxidoreductase 0.0008 0.0006 0.0031
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.044 0.2044 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0454 0.8324
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0028 0.0562
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0027 0.0027
Brugia malayi hypothetical protein 0.0025 0.0087 0.0296
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0006 0.0015
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0008 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.009 0.0395 0.135
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.011 0.0262
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0104 0.0355
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0008 0.0006 0.0031
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0011 0.0037
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0006 0.0015
Schistosoma mansoni glucose transport protein 0.001 0.0017 0.0017
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0008 0.0006 0.0031
Brugia malayi hypothetical protein 0.001 0.0017 0.006
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Onchocerca volvulus 0.001 0.0017 0.0052
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0006 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0104 0.0355
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.011 0.2025
Leishmania major hypothetical protein, conserved 0.001 0.0017 0.032
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0017 0.0353
Onchocerca volvulus 0.0008 0.0006 0.0019
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0008 0.0006 0.0031
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.044 0.2044 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Brugia malayi 6-phosphofructokinase 0.0112 0.0495 0.1691
Brugia malayi CXXC zinc finger family protein 0.0029 0.0107 0.0367
Echinococcus multilocularis lamin dm0 0.0029 0.0104 0.0104
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0006 0.0015
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni carbonyl reductase 0.0008 0.0006 0.0006
Onchocerca volvulus 0.001 0.0017 0.0052
Trypanosoma brucei oxidoreductase-like protein 0.0008 0.0006 0.0128
Trichomonas vaginalis glucose transporter, putative 0.001 0.0017 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.09 0.4217 1
Giardia lamblia Short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.001 0.0017 0.0086
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0007 0.0001 0.0001
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0008 0.0006 0.0128
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0034 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0454 0.1077
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0008 0.0006 0.0031
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0006 0.0006
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0008 0.0006 0.034
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.011 0.2678
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.001 0.0017 0.0086
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0303 0.1035
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0495 0.1173
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0495 0.1173
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0008 0.0006 0.0015
Onchocerca volvulus 0.0029 0.0104 0.0311
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0041
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0187 0.0915
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Onchocerca volvulus 0.001 0.0017 0.0052
Onchocerca volvulus 0.0008 0.0006 0.0019
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0006 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0395 0.0395
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0006 0.0128
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0187 0.4646
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0008 0.0006 0.0031
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.0353
Loa Loa (eye worm) phosphofructokinase 0.0112 0.0495 0.1691
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0006 0.0128
Schistosoma mansoni cpg binding protein 0.0031 0.0115 0.0115
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0008 0.0006 0.0031
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0006 0.0015
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0008 0.0006 0.0019
Brugia malayi major facilitator superfamily protein 0.001 0.0017 0.006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0454 0.9179
Mycobacterium tuberculosis Possible oxidoreductase 0.0008 0.0006 0.0031
Leishmania major hypothetical protein, conserved 0.0008 0.0006 0.0116
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0006 0.0128
Onchocerca volvulus 0.001 0.0017 0.0052
Loa Loa (eye worm) RecQ helicase 0.0022 0.0072 0.0245
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0454 0.1077
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0017 0.0353
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0546 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.001 0.0017 0.0017
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.012 0.0535 0.1826
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0041 0.014
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0087 0.1748
Echinococcus granulosus Solute carrier family 22 5 0.1103 0.5172 0.5172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0546 0.267
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Mycobacterium leprae Probable oxidoreductase 0.0008 0.0006 0.0031
Echinococcus granulosus solute carrier family 22 0.001 0.0017 0.0017
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0495 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0132 0.0314
Onchocerca volvulus 0.0008 0.0006 0.0019
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0116
Leishmania major short chain dehydrogenase, putative 0.0008 0.0006 0.0116
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0495 0.0495
Trichomonas vaginalis glucose transporter, putative 0.001 0.0017 0.0041
Trypanosoma cruzi hexose transporter, putative 0.001 0.0017 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.09 0.4217 1
Leishmania major glucose transporter, lmgt2 0.001 0.0017 0.032
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0006 0.0128
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0454 0.1077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0346
Toxoplasma gondii sugar transporter ST2 0.001 0.0017 0.032
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Onchocerca volvulus 0.0008 0.0006 0.0019
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Entamoeba histolytica hypothetical protein 0.0046 0.0187 0.0444
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0006 0.0128
Leishmania major short chain dehydrogenase-like protein 0.0008 0.0006 0.0116
Giardia lamblia Fructose-bisphosphate aldolase 0.09 0.4217 1
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.0353
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.0353
Onchocerca volvulus 0.0008 0.0006 0.0019
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.001 0.0017 0.0935
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0006 0.0031
Trichomonas vaginalis sugar transport protein, putative 0.001 0.0017 0.0041
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0006 0.0128
Brugia malayi hypothetical protein 0.0016 0.0045 0.0152
Toxoplasma gondii facilitative glucose transporter GT1 0.001 0.0017 0.032
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0008 0.0006 0.0031
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0006 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0006 0.0128
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.0314
Trichomonas vaginalis glucose transporter, putative 0.001 0.0017 0.0041
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0011 0.0026
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0006 0.0006
Brugia malayi Pre-SET motif family protein 0.0627 0.2927 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0023 0.0474
Mycobacterium ulcerans dehydrogenase/reductase 0.0008 0.0006 0.0031
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0187 0.0915
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0087 0.1748
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0008 0.0006 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0087 0.4436
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0006 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0395 0.0395
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0006 0.0116
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0008 0.0006 0.0031
Brugia malayi Sugar transporter family protein 0.001 0.0017 0.006
Onchocerca volvulus 0.001 0.0017 0.0052
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0021 0.0021
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.011 0.0262
Leishmania major basic transcription factor 3a, putative 0.0035 0.0132 0.2424
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.001 0.0017 0.0017
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0008 0.0006 0.0128
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0546 0.267
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0041
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0008 0.0006 0.0031
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0132 0.2673
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0006 0.0128
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0027 0.0092
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Brugia malayi oxidoreductase 0.0008 0.0006 0.0022
Echinococcus multilocularis geminin 0.0181 0.082 0.082
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0026 0.009
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0011 0.0037
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0187 0.0915
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.0495 0.2421
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0011 0.0011
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0495 0.1173
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0041
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0132 0.2673
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0187 0.3428
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0006 0.0006
Onchocerca volvulus 0.001 0.0017 0.0052
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.012 0.0535 0.2616
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0011 0.0011
Schistosoma mansoni sugar transporter 0.001 0.0017 0.0017
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0011 0.0252
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0116
Brugia malayi phosphofructokinase 0.0112 0.0495 0.1691
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0006 0.0015
Echinococcus granulosus bloom syndrome protein 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0132 0.0314
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.0353
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0071 0.0303 0.6123
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0495 0.0495
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0546 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0041
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0006 0.0022
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0116
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0454 0.8324
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0037 0.0684
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0071 0.0303 0.1035
Onchocerca volvulus 0.009 0.0395 0.1185
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0546 0.267
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0279 0.0279
Leishmania major cytochrome p450-like protein 0.0013 0.0028 0.051
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Echinococcus multilocularis solute carrier family 22 0.001 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0454 0.0454
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Schistosoma mansoni sugar transporter 0.001 0.0017 0.0017
Schistosoma mansoni glucose transporter 0.001 0.0017 0.0017
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0.0006 0.0128
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.0495 0.0495
Echinococcus multilocularis solute carrier family 22 0.001 0.0017 0.0017
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0008 0.0006 0.0031
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0006 0.0006
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0023 0.0056
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Entamoeba histolytica hypothetical protein 0.0008 0.0006 0.0015
Leishmania major hypothetical protein, conserved 0.0008 0.0006 0.0116
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.001 0.0017 0.0616
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0018 0.0018
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0008 0.0006 0.0031
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.001 0.0017 0.0017
Leishmania major 3-keto-dihydrosphingosine reductase 0.0008 0.0006 0.0116
Leishmania major glucose transporter, lmgt1 0.001 0.0017 0.032
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0023 0.0474
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0011 0.0011
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0006 0.0031
Schistosoma mansoni intermediate filament proteins 0.0029 0.0104 0.0104
Echinococcus granulosus intermediate filament protein 0.0029 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0107
Trypanosoma brucei glucose transporter 1E 0.001 0.0017 0.0353
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0006 0.0022
Echinococcus multilocularis transcription factor btf3 0.0035 0.0132 0.0132
Onchocerca volvulus Putative transporter 0.001 0.0017 0.0052
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0008 0.0006 0.0031
Echinococcus granulosus cpg binding protein 0.0031 0.0115 0.0115
Schistosoma mansoni cpg binding protein 0.0031 0.0115 0.0115
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Mycobacterium ulcerans oxidoreductase 0.0008 0.0006 0.0031
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0006 0.0128
Trypanosoma cruzi hexose transporter, putative 0.001 0.0017 0.0353
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0165 0.0746 0.2549
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.011 0.0262
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0006 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Giardia lamblia Hexose transporter 0.001 0.0017 0.0041
Schistosoma mansoni hypothetical protein 0.001 0.0017 0.0017
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0071 0.0303 0.6123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0041
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0104 0.0355
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0028 0.0562
Loa Loa (eye worm) hypothetical protein 0.0025 0.0087 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0015 0.0309
Onchocerca volvulus 0.001 0.0017 0.0052
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0006 0.0006
Echinococcus multilocularis synaptic vesicle 2 protein 0.001 0.0017 0.0017
Onchocerca volvulus 0.0008 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0006 0.0015
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Toxoplasma gondii sugar transporter ST3 0.001 0.0017 0.032
Onchocerca volvulus 0.001 0.0017 0.0052
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.001 0.0017 0.0086
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0006 0.0022
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0116
Toxoplasma gondii transporter, major facilitator family protein 0.001 0.0017 0.032
Brugia malayi Pre-SET motif family protein 0.009 0.0395 0.135
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0.0006 0.0116
Trypanosoma cruzi hexose transporter, putative 0.001 0.0017 0.0353
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Trypanosoma brucei glucose transporter 2A 0.001 0.0017 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0041
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0006 0.0022
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0071 0.0303 0.6123
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0006 0.0006
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0006 0.0128
Echinococcus granulosus lamin 0.0029 0.0104 0.0104
Plasmodium vivax SET domain protein, putative 0.009 0.0395 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0165 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Leishmania major short chain dehydrogenase, putative 0.0008 0.0006 0.0116
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.011 0.0262
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0006 0.0128
Mycobacterium ulcerans sugar transporter 0.001 0.0017 0.0086
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0017 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0132 0.0314
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0006 0.0006
Trypanosoma cruzi sugar transporter, putative 0.001 0.0017 0.0353
Schistosoma mansoni cpg binding protein 0.0029 0.0107 0.0107
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0454 0.8324
Leishmania major dehydrogenase-like protein 0.0008 0.0006 0.0116
Schistosoma mansoni microtubule-associated protein tau 0.2126 1 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0008 0.0006 0.0031
Schistosoma mansoni sugar transporter 0.001 0.0017 0.0017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0006 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.012 0.0535 0.0535
Schistosoma mansoni hypothetical protein 0.0181 0.082 0.082
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0006 0.0031
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0023 0.043
Echinococcus granulosus solute carrier family 22 0.001 0.0017 0.0017
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0071 0.0303 0.0303
Onchocerca volvulus 0.001 0.0017 0.0052
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0038 0.0817
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0006 0.0015
Leishmania major myo-inositol/proton symporter (MIT) 0.001 0.0017 0.032
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0132 0.697
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0017 0.006
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0072 0.017
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0006 0.0116
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0247 0.4535
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni DNA helicase recq5 0.0009 0.0011 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0107 0.0367
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0006 0.0116
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0028 0.0562
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0072 0.0245
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.09 0.4217 1
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Onchocerca volvulus 0.001 0.0017 0.0052
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0.0006 0.0116
Loa Loa (eye worm) hypothetical protein 0.0165 0.0746 0.2549
Echinococcus granulosus hypothetical protein 0.0008 0.0006 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0107
Echinococcus multilocularis cpg binding protein 0.0031 0.0115 0.0115
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.011 0.5764
Mycobacterium ulcerans carveol-like dehydrogenase 0.0008 0.0006 0.0031
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0071 0.0303 0.6123
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.0495 0.0495
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0546 0.267
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0006 0.0128
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0087 0.2061
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0023 0.0056
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0495 0.1691
Echinococcus granulosus transcription factor btf3 0.0035 0.0132 0.0132
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0454 0.0454
Trichomonas vaginalis set domain proteins, putative 0.0714 0.3335 0.7909
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.09 0.4217 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0006 0.0015
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0454 0.9179
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0011 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.011 0.0262
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0008 0.0006 0.0019
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0454 0.9179
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.001 0.0017 0.0086
Schistosoma mansoni lamin 0.0029 0.0104 0.0104
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0006 0.0128
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0546 0.0546
Leishmania major hypothetical protein, conserved 0.0025 0.0087 0.1585
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0028 0.0095
Echinococcus multilocularis solute carrier family 22 0.001 0.0017 0.0017
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0008 0.0006 0.0031
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0006 0.0015
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0071 0.0303 0.5553
Trichomonas vaginalis myo-inositol transporter, putative 0.001 0.0017 0.0041
Leishmania major hypothetical protein, conserved 0.001 0.0015 0.0281
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0187 0.0915
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0546 0.0546
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0395 0.0395
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0041
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Echinococcus granulosus solute carrier family 22 0.001 0.0017 0.0017
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0495 1
Echinococcus multilocularis microtubule associated protein 2 0.2126 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.012 0.0535 0.2616
Echinococcus granulosus hypothetical protein 0.0008 0.0006 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0006 0.0006
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0006 0.0006
Echinococcus granulosus solute carrier family 22 0.001 0.0017 0.0017
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0116
Loa Loa (eye worm) sugar transporter 0.001 0.0017 0.006
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0008 0.0006 0.0128
Echinococcus granulosus synaptic vesicle 2 protein 0.001 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.09 0.4217 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0059 0.2917
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.011 0.0262
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0627 0.2927 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0377 0.0377
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0006 0.0116
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0006 0.0128
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Leishmania major oxidoreductase-like protein 0.0008 0.0006 0.0116
Schistosoma mansoni DNA helicase recq1 0.0009 0.0011 0.0011
Treponema pallidum fructose-bisphosphate aldolase 0.09 0.4217 1
Schistosoma mansoni hypothetical protein 0.0011 0.0021 0.0021
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.012 0.0535 0.0535
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0071 0.0303 0.0909
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0395 0.0395
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0006 0.0031
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0006 0.0128
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Echinococcus multilocularis Sugar transporter ERD6 protein 0.001 0.0017 0.0017
Onchocerca volvulus 0.001 0.0017 0.0052
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0008 0.0006 0.0031
Brugia malayi hypothetical protein 0.0008 0.0006 0.0022
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0006 0.0031
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0006 0.0128
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0006 0.0031
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0006 0.0006
Echinococcus granulosus lamin dm0 0.0029 0.0104 0.0104
Mycobacterium ulcerans integral membrane transport protein 0.001 0.0017 0.0086
Mycobacterium tuberculosis Probable dehydrogenase 0.0008 0.0006 0.0031
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.005 0.005
Onchocerca volvulus 0.0008 0.0006 0.0019
Leishmania major glucose transporter/membrane transporter D2, putative 0.001 0.0017 0.032
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0017 0.006
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0006 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Loa Loa (eye worm) dehydrogenase 0.0008 0.0006 0.0022
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0017 0.006
Leishmania major glucose transporter, lmgt3 0.001 0.0017 0.032
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Loa Loa (eye worm) POT family protein 0.0087 0.0378 0.1293
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0454 0.1077
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0454 0.0454
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0071 0.0303 0.6123
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0006 0.0031
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0006 0.0031
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0072 0.0072
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.012 0.0535 0.9797
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0006 0.0031
Onchocerca volvulus 0.001 0.0017 0.0052
Trypanosoma cruzi hexose transporter, putative 0.001 0.0017 0.0353
Onchocerca volvulus 0.0165 0.0746 0.2237
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0.0006 0.0116
Plasmodium falciparum hexose transporter 0.001 0.0017 0.0616
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0006 0.0128
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0006 0.0116
Mycobacterium tuberculosis Possible oxidoreductase 0.0008 0.0006 0.0031
Schistosoma mansoni glucose transport protein 0.001 0.0017 0.0017
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.0495 0.2421
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0064 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0011 0.02
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.09 0.4217 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0173
Onchocerca volvulus 0.0008 0.0006 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.09 0.4217 1
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0015 0.0309
Giardia lamblia Reductase, putative 0.0008 0.0006 0.0015
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.0353
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0546 1
Echinococcus granulosus oxidoreductase 0.0008 0.0006 0.0006
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0.0006 0.0116
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.0353
Loa Loa (eye worm) dehydrogenase 0.0008 0.0006 0.0022
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0008 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0071 0.0303 0.6123
Loa Loa (eye worm) sugar transporter 0.001 0.0017 0.006
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.0495 0.2421
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0017 0.006
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.0495 0.9069
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Brugia malayi Sugar transporter family protein 0.001 0.0017 0.006
Echinococcus granulosus geminin 0.0181 0.082 0.082
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.011 0.0262
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0006 0.0116
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0006 0.0006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.044 0.2044 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Brugia malayi POT family protein 0.0087 0.0378 0.1293
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0495 0.1173
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0011 0.02
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trypanosoma brucei sugar transporter, putative 0.001 0.0017 0.0353
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Onchocerca volvulus 0.001 0.0017 0.0052
Brugia malayi hypothetical protein 0.001 0.0017 0.006
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0714 0.3335 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0006 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0087 0.1748
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0006 0.0022
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0006 0.0116
Echinococcus multilocularis L aminoadipate semialdehyde 0.0165 0.0746 0.0746
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0006 0.0128
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0495 0.1691
Plasmodium vivax hexose transporter 0.001 0.0017 0.0286
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0006 0.0006
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0132 0.0314
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0495 0.1173
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0006 0.0015
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0165 0.0746 0.0746
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0008 0.0006 0.0031
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0021 0.0021
Trypanosoma brucei glucose transporter, putative 0.001 0.0017 0.0353
Onchocerca volvulus 0.0008 0.0006 0.0019
Onchocerca volvulus 0.0008 0.0006 0.0019
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0006 0.0116
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0041 0.014
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0022
Brugia malayi beta-NAC-like protein 0.0035 0.0132 0.0452
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0017 0.0041
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0006 0.0031
Echinococcus multilocularis musashi 0.0029 0.0104 0.0104
Schistosoma mansoni sugar transporter 0.001 0.0017 0.0017
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0132 0.2673
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0087 0.4436
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0454 0.9179
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Trypanosoma cruzi hexose transporter 0.001 0.0017 0.0353
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.09 0.4217 1
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0495 0.1173
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Brugia malayi 6-phosphofructokinase 0.0112 0.0495 0.1691
Schistosoma mansoni hypothetical protein 0.0181 0.082 0.082
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0454 0.1077
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0006 0.0015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.012 0.0535 0.2616
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0454 0.0454
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Echinococcus multilocularis solute carrier family 22 0.001 0.0017 0.0017
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Onchocerca volvulus 0.0029 0.0104 0.0311
Echinococcus granulosus lysosomal protective protein 0.0071 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0027 0.0027
Echinococcus multilocularis lysosomal protective protein 0.0071 0.0303 0.0303
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.011 0.0262
Brugia malayi major facilitator superfamily protein 0.001 0.0017 0.006
Schistosoma mansoni transcription factor btf3 0.0035 0.0132 0.0132
Brugia malayi MAP kinase sur-1 0.0103 0.0454 0.1552
Giardia lamblia Hypothetical protein 0.0008 0.0006 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.011 0.0262
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0132 0.3239
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0006 0.0006
Brugia malayi intermediate filament protein 0.0029 0.0104 0.0355
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0004 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0028 0.0095
Brugia malayi Cytochrome P450 family protein 0.0013 0.0028 0.0095
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0006 0.0128
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0006 0.0015
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0006 0.0128
Onchocerca volvulus 0.001 0.0017 0.0052
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0064 0.027 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0006 0.0128
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0071 0.0303 0.0303
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0006 0.0128
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0006 0.0022
Trypanosoma brucei protein kinase, putative 0.0103 0.0454 0.9179
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.011 0.2678
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0006 0.0006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0395 0.7243
Leishmania major hypothetical protein, conserved 0.0008 0.0006 0.0116
Plasmodium vivax sugar transporter, putative 0.001 0.0017 0.0286
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0034 0.0034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0017 0.0017
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0006 0.0116
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.006
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0018 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.09 0.4217 1
Trypanosoma cruzi glucose transporter, putative 0.001 0.0017 0.0353
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0454 0.1552
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0006 0.0128
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0006 0.0031
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0006 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0008 0.0006 0.0128
Onchocerca volvulus Sepiapterin reductase homolog 0.0008 0.0006 0.0019
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.09 0.4217 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0187 1
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0008 0.0006 0.0116
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.011 0.2025
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0008 0.0006 0.0128
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0037
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0495 0.1173
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0112 0.0496 0.1696
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0187 1
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0132 0.2424
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0006 0.0031
Onchocerca volvulus 0.001 0.0017 0.0052
Schistosoma mansoni carbonyl reductase 0.0008 0.0006 0.0006
Schistosoma mansoni glucose transport protein 0.001 0.0017 0.0017
Trichomonas vaginalis sugar transporter, putative 0.001 0.0017 0.0041
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.011 0.5764
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0006 0.0031
Brugia malayi hypothetical protein 0.001 0.0017 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0006 0.0128

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.52 Inhibition constant of compound against binding of Yeast Glyoxalase I ChEMBL. 3290487
Log Ki (binding) = 4.52 Inhibition constant of compound against binding of Yeast Glyoxalase I ChEMBL. 3290487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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