Detailed information for compound 513299

Basic information

Technical information
  • TDR Targets ID: 513299
  • Name: N,N-dimethyl-7H-purin-6-amine
  • MW: 163.18 | Formula: C7H9N5
  • H donors: 1 H acceptors: 3 LogP: 0.56 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ncnc2c1[nH]cn2)C
  • InChi: 1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
  • InChiKey: BVIAOQMSVZHOJM-UHFFFAOYSA-N  


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Synonyms

  • dimethyl(7H-purin-6-yl)amine
  • N(6),N(6)-dimethyladenine
  • dimethyl-(7H-purin-6-yl)amine
  • 938-55-6
  • D2629_SIGMA
  • IDI1_011608
  • Maybridge3_000221
  • 1H-Purin-6-amine, N,N-dimethyl- (9CI)
  • 6-Dimethyladenine
  • 6-Dimethylaminopurine
  • Adenine, N,N-dimethyl- (8CI)
  • EINECS 213-344-3
  • N,N-Dimethyladenine
  • NSC 401568
  • 1H-Purin-6-amine, N,N-dimethyl-
  • 6-(Dimethylamino)purine
  • Adenine, N,N-dimethyl-
  • Dimethylaminopurine
  • N6,N6-Dimethyladenine
  • NSC401568
  • ZINC00066101
  • SBB003924
  • 6 DMAP
  • Protein Kinase Inhibitor, DMAP
  • AG-670/25003543

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase A Starlite/ChEMBL No references
Homo sapiens protein kinase C, delta Starlite/ChEMBL No references
Homo sapiens protein tyrosine kinase 2 beta Starlite/ChEMBL References
Homo sapiens checkpoint kinase 2 Starlite/ChEMBL No references
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Starlite/ChEMBL No references
Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa Starlite/ChEMBL References
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens checkpoint kinase 1 Starlite/ChEMBL No references
Homo sapiens cyclin E1 Starlite/ChEMBL References
Homo sapiens MAP/microtubule affinity-regulating kinase 3 Starlite/ChEMBL No references
Homo sapiens 3-phosphoinositide dependent protein kinase 1 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 Get druggable targets OG5_128785 All targets in OG5_128785
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase Get druggable targets OG5_128024 All targets in OG5_128024
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase Chk2 Get druggable targets OG5_128695 All targets in OG5_128695
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AGC/PDK1 protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Schistosoma japonicum ko:K08798 MAP/microtubule affinity-regulating kinase, putative Get druggable targets OG5_128024 All targets in OG5_128024
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Protein tyrosine kinase 2 beta, putative Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_128024 All targets in OG5_128024
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130454 All targets in OG5_130454
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase Get druggable targets OG5_128024 All targets in OG5_128024
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis serine:threonine protein kinase MARK2 Get druggable targets OG5_128024 All targets in OG5_128024
Loa Loa (eye worm) TK/FAK protein kinase Get druggable targets OG5_130513 All targets in OG5_130513
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130513 All targets in OG5_130513
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus multilocularis serine:threonine protein kinase Get druggable targets OG5_128024 All targets in OG5_128024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus granulosus serine:threonine protein kinase Get druggable targets OG5_128024 All targets in OG5_128024
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans kinase involved in DNA repair Get druggable targets OG5_128695 All targets in OG5_128695
Schistosoma japonicum ko:K06641 serine/threonine-protein kinase Chk2, putative Get druggable targets OG5_128695 All targets in OG5_128695
Leishmania infantum rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase Get druggable targets OG5_128695 All targets in OG5_128695
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus calcium:calmodulin dependent protein kinase I Get druggable targets OG5_128695 All targets in OG5_128695
Echinococcus granulosus serine:threonine protein kinase MARK2 Get druggable targets OG5_128024 All targets in OG5_128024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K06276 3-phosphoinositide dependent protein kinase-1, putative Get druggable targets OG5_128785 All targets in OG5_128785
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase Chk2 Get druggable targets OG5_128695 All targets in OG5_128695
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/RSK/RSK protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani rac serine-threonine kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I Get druggable targets OG5_128695 All targets in OG5_128695
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_128695 All targets in OG5_128695
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128024 All targets in OG5_128024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase Get druggable targets OG5_128024 All targets in OG5_128024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Candida albicans kinase involved in DNA repair Get druggable targets OG5_128695 All targets in OG5_128695
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans likely protein kinase similar to S. cerevisiae KIN1 (YDR122W) and KIN2 (YLR096W) Get druggable targets OG5_128024 All targets in OG5_128024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, AGC AKT Get druggable targets OG5_128147 All targets in OG5_128147
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi phosphoinositide-dependent protein kinase I Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_128695 All targets in OG5_128695
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein kinase Get druggable targets OG5_128695 All targets in OG5_128695
Schistosoma japonicum IPR000719,Protein kinase,domain-containing Get druggable targets OG5_128147 All targets in OG5_128147
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
Loa Loa (eye worm) AGC/PDK1 protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Get druggable targets OG5_130454 All targets in OG5_130454
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_128024 All targets in OG5_128024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 Get druggable targets OG5_128785 All targets in OG5_128785
Brugia malayi ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma japonicum Ribosomal protein S6 kinase alpha-2, putative Get druggable targets OG5_128147 All targets in OG5_128147
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128024 All targets in OG5_128024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128695 All targets in OG5_128695
Candida albicans similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase MARK2 Get druggable targets OG5_128024 All targets in OG5_128024
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128024 All targets in OG5_128024
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_128147 All targets in OG5_128147
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus multilocularis serine:threonine protein kinase MARK2 Get druggable targets OG5_128024 All targets in OG5_128024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis protein ssnA, putative 0.0314 0.0934 0.4313
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0017 0.0012
Echinococcus multilocularis calcium activated potassium channel 0.0078 0.0199 0.0195
Trichomonas vaginalis cyclins, putative 0.0021 0.0024 0.003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.007 0.0248
Trypanosoma brucei rac serine-threonine kinase, putative 0.0034 0.0062 0.0179
Schistosoma mansoni lipoxygenase 0.002 0.0019 0.004
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0017 0.0066
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0017 0.0079
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.018 0.1192
Trichomonas vaginalis cyclin D, putative 0.0021 0.0024 0.003
Trypanosoma brucei unspecified product 0.0019 0.0017 0.0036
Onchocerca volvulus 0.0041 0.0083 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0083 0.0436
Loa Loa (eye worm) hypothetical protein 0.0123 0.034 0.1804
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0017 0.0185
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0056 0.0131 0.0397
Entamoeba histolytica protein kinase, putative 0.0034 0.0062 0.0667
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0052 0.012 0.0376
Echinococcus granulosus lamin dm0 0.0053 0.0123 0.0283
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0088 0.0232 0.0228
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.003 0.1294
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0131 0.0307
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.018 0.1192
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0206 0.0598 0.3181
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0033 0.0101
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0006 0.0024
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.013 0.0298
Brugia malayi serine/threonine protein kinase 6 0.0072 0.0181 0.0944
Echinococcus granulosus muscleblind protein 0.0295 0.0877 0.2075
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0052 0.012 0.6531
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.018 0.0176
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0062 0.0138
Entamoeba histolytica protein kinase, putative 0.0034 0.0062 0.0667
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.087 0.4015
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0006 0.001
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.035 0.0823
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0396 0.0938
Loa Loa (eye worm) hypothetical protein 0.0052 0.012 0.0631
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.018 0.0765
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Trypanosoma brucei mitotic cyclin 6 0.0021 0.0024 0.0056
Trichomonas vaginalis cyclins, putative 0.0021 0.0024 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0199 0.0469
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0083 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Entamoeba histolytica protein kinase, putative 0.0072 0.0181 0.1939
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0017 0.007
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.1027 0.3155 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0021 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.009
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0052 0.012 0.0116
Schistosoma mansoni hypothetical protein 0.0046 0.01 0.0234
Leishmania major dihydroorotase, putative 0.0046 0.01 0.0299
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.007 0.0749
Mycobacterium tuberculosis Conserved protein 0.0072 0.018 0.1192
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0073 0.0068
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0131 0.041
Brugia malayi Protein kinase domain containing protein 0.0206 0.0598 0.3172
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0083 0.0079
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0073 0.0777
Onchocerca volvulus 0.0702 0.2142 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0163 0.1749
Echinococcus multilocularis thyroid hormone receptor alpha 0.0167 0.0477 0.0473
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0135 0.0377 0.0373
Brugia malayi Hr1 repeat family protein 0.0034 0.0062 0.031
Trypanosoma cruzi dihydroorotase, putative 0.0046 0.01 0.0312
Plasmodium falciparum protein kinase 5 0.0056 0.0131 0.7149
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0118 0.0324 0.1445
Loa Loa (eye worm) hypothetical protein 0.0123 0.034 0.1804
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0141 0.0137
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0006 0.0005
Onchocerca volvulus 0.0053 0.0123 0.0501
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0118
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0086 0.0324
Loa Loa (eye worm) hypothetical protein 0.005 0.0112 0.0586
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0021 0.0024 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0503 0.1191
Trypanosoma cruzi aurora B kinase, putative 0.0072 0.0181 0.0568
Echinococcus granulosus dihydropyrimidinase 2 0.0046 0.01 0.0228
Schistosoma mansoni DNA polymerase eta 0.0019 0.0017 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0167 0.0477 0.1129
Echinococcus granulosus imidazolonepropionase 0.0046 0.01 0.0228
Echinococcus granulosus aurora kinase A 0.0072 0.0181 0.042
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.0004 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0052 0.012 0.0485
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0123 0.0648
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.005 0.0112 0.0108
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0053 0.0149
Schistosoma mansoni loxhd1 0.002 0.0019 0.004
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0131 0.041
Schistosoma mansoni cyclin B 0.0021 0.0024 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0324 0.1023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0436
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0181 0.0956
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0019 0.072
Loa Loa (eye worm) hypothetical protein 0.0088 0.0232 0.123
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0105 0.0285 0.0886
Brugia malayi conserved hypotetical protein 0.0019 0.0017 0.0066
Trypanosoma cruzi imidazolonepropionase, putative 0.0046 0.01 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Echinococcus multilocularis aurora kinase A 0.0072 0.0181 0.0177
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0073 0.026
Loa Loa (eye worm) acetyltransferase 0.0141 0.0396 0.2105
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0072 0.0181 0.7791
Trypanosoma brucei inosine-adenosine-guanosine-nucleosidehydrolase 0.1027 0.3155 1
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0019 0.0014
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0024 0.0104
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0006 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0062 0.0144
Trypanosoma brucei dihydroorotase, putative 0.0046 0.01 0.0299
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.007 0.0364
Leishmania major inosine-adenosine-guanosine-nucleoside hydrolase, putative 0.1027 0.3155 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0052 0.012 0.0376
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0209
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.003 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0083 0.0422
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0023
Schistosoma mansoni nuclear receptor 0.0019 0.0017 0.0035
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.007 0.0203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0147 0.1413
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0088 0.0232 0.0548
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0091 0.0212
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0118 0.0324 0.1445
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0033 0.1438
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0083 0.0194
Echinococcus granulosus calcium activated potassium channel 0.0078 0.0199 0.0464
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0083 0.0422
Loa Loa (eye worm) hypothetical protein 0.0295 0.0877 0.4667
Echinococcus granulosus serine:threonine protein kinase 0.0102 0.0274 0.0642
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0377 0.0892
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0006 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0091 0.0212
Echinococcus multilocularis cyclins 0.0021 0.0024 0.0019
Trypanosoma cruzi cyclin 6, putative 0.0021 0.0024 0.007
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0023
Mycobacterium leprae Probable dihydroorotase PyrC (DHOase) 0.0046 0.01 0.1878
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0045 0.004
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0403 0.4211
Echinococcus multilocularis GPCR, family 2 0.0016 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0176 0.0504 0.2681
Onchocerca volvulus 0.0021 0.0024 0.0034
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0017 0.0066
Brugia malayi Protein kinase domain containing protein 0.0102 0.0274 0.1441
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0073 0.0365
Brugia malayi Protein kinase domain containing protein 0.0056 0.0131 0.0677
Mycobacterium leprae Probable lipase LipE 0.0072 0.018 0.4015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.018 0.1192
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0052 0.012 0.0116
Schistosoma mansoni hypothetical protein 0.0507 0.1536 0.3646
Echinococcus granulosus phd:f box containing protein 0.0016 0.0006 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0152 0.0634
Giardia lamblia Aurora kinase 0.0072 0.0181 0.1919
Echinococcus granulosus intermediate filament protein 0.0053 0.0123 0.0283
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0017 0.0066
Schistosoma mansoni serine/threonine kinase 0.0034 0.0062 0.0144
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0152 0.0634
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.007 0.0248
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0006 0.0004
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0017 0.0035
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0029 0.0049 0.0148
Echinococcus multilocularis imidazolonepropionase 0.0046 0.01 0.0096
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0131 0.0127
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0075 0.0808
Mycobacterium ulcerans lipase LipD 0.0072 0.018 0.1774
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0147 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0083 0.0436
Echinococcus multilocularis dihydropyrimidinase protein 4 0.0046 0.01 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0083 0.0436
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0017 0.0049
Loa Loa (eye worm) hypothetical protein 0.0053 0.0123 0.0648
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.087 0.4015
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.0023
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.018 0.1192
Schistosoma mansoni lipoxygenase 0.0055 0.013 0.0304
Mycobacterium tuberculosis Conserved protein 0.0072 0.018 0.1192
Schistosoma mansoni cyclin B3 0.0021 0.0024 0.0052
Onchocerca volvulus 0.0072 0.018 0.0768
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0173
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0017 0.0079
Echinococcus granulosus cyclin dependent kinase 5 0.0056 0.0131 0.0302
Brugia malayi hypothetical protein 0.002 0.0019 0.0077
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0147 0.1413
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Entamoeba histolytica protein kinase, putative 0.0063 0.0152 0.1628
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0011
Schistosoma mansoni vav2 0.0015 0.0004 0.0006
Trypanosoma cruzi cyclin, putative 0.0021 0.0024 0.007
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0053 0.0149
Trypanosoma cruzi imidazolonepropienase, putative 0.0046 0.01 0.0312
Echinococcus multilocularis cyclins 0.0021 0.0024 0.0019
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0084 0.0313
Schistosoma mansoni dihydropyrimidinase related protein-1 (M38 family) 0.0046 0.01 0.0234
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0436
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0045 0.1865
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0113 0.0592
Trichomonas vaginalis esterase, putative 0.0072 0.018 0.0765
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0024 0.0104
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0436
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0024
Echinococcus granulosus cyclin B 0.0021 0.0024 0.0046
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0052 0.012 0.0276
Schistosoma mansoni rab6-interacting 0.002 0.0019 0.004
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.007 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Echinococcus granulosus cyclins 0.0021 0.0024 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0147 0.0949
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0017 0.0029
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0118 0.0324 0.1445
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0378
Trypanosoma brucei glucosidase, putative 0.0036 0.007 0.0203
Brugia malayi nuclear hormone receptor 0.0041 0.0083 0.0422
Leishmania major DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.087 0.4015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0232 0.0548
Giardia lamblia Cyclin A 0.0021 0.0024 0.0075
Mycobacterium ulcerans hypothetical protein 0.0072 0.018 0.1774
Echinococcus granulosus NDR protein kinase 0.0034 0.0062 0.0138
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0033 0.1375
Schistosoma mansoni hypothetical protein 0.0034 0.0063 0.0147
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0131 0.041
Loa Loa (eye worm) hypothetical protein 0.0083 0.0217 0.1147
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0131 0.1334
Echinococcus multilocularis protein kinase c iota type 0.0043 0.0091 0.0086
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0033 0.0101
Mycobacterium leprae conserved hypothetical protein 0.0072 0.018 0.4015
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0131 0.1404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.018 0.0423
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0123 0.0648
Echinococcus granulosus cyclin dependent kinase 0.0056 0.0131 0.0302
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0043 0.0091 0.0475
Echinococcus granulosus dna polymerase kappa 0.0019 0.0017 0.0031
Entamoeba histolytica hypothetical protein 0.0035 0.0066 0.0708
Echinococcus multilocularis serine:threonine protein kinase 0.0102 0.0274 0.027
Trichomonas vaginalis D-aminoacylase, putative 0.0046 0.01 0.039
Loa Loa (eye worm) hypothetical protein 0.0072 0.018 0.095
Trichomonas vaginalis cyclin B, putative 0.0021 0.0024 0.003
Trypanosoma brucei guanine deaminase, putative 0.0314 0.0934 0.2945
Echinococcus multilocularis cyclin dependent kinase 0.0056 0.0131 0.0127
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0056 0.0131 0.0302
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0062 0.0058
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0021 0.0024 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0436
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0024 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.012 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0073 0.026
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0017 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0083 0.0422
Brugia malayi hypothetical protein 0.0021 0.0024 0.0104
Brugia malayi hypothetical protein 0.0021 0.0024 0.0104
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0046 0.0236
Schistosoma mansoni DNA helicase recq5 0.0028 0.0045 0.0102
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0436
Echinococcus granulosus protein kinase c epsilon type 0.0043 0.0091 0.0206
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0011
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0072 0.0181 0.1939
Echinococcus multilocularis hypothetical protein 0.0073 0.0186 0.0181
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0017 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0181 0.077
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.018 0.0765
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0083 0.0422
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0052 0.012 0.062
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.003 0.0327
Entamoeba histolytica cyclin, putative 0.0021 0.0024 0.0254
Brugia malayi nuclear receptor NHR-67 0.0019 0.0017 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0083 0.0422
Echinococcus granulosus GPCR family 2 0.0016 0.0006 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0181 0.077
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0063 0.0152 0.0802
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0083 0.0188
Entamoeba histolytica protein kinase, putative 0.0034 0.0062 0.0667
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0017 0.0031
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0033 0.141
Trichomonas vaginalis cyclins, putative 0.0021 0.0024 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0232 0.0548
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0024 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0017 0.0036
Echinococcus multilocularis musashi 0.0053 0.0123 0.0119
Schistosoma mansoni glutaminase 0.0274 0.0811 0.1924
Onchocerca volvulus 0.0088 0.0232 0.1015
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.0107 0.0244
Brugia malayi glutaminase DH11.1 0.0274 0.0811 0.431
Schistosoma mansoni polycystin 1-related 0.002 0.0019 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0045 0.1865
Brugia malayi beta-lactamase family protein 0.0072 0.018 0.0938
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0006 0.0014
Plasmodium vivax SET domain protein, putative 0.0088 0.0232 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0083 0.0194
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.005 0.0112 0.0257
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0043 0.0091 0.0086
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0088 0.0232 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0073 0.0168
Loa Loa (eye worm) glutaminase 0.0274 0.0811 0.4318
Echinococcus multilocularis cyclin b3 0.0021 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0034 0.0063 0.033
Trichomonas vaginalis cyclins, putative 0.0021 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.005 0.0113 0.0592
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0083 0.0422
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0034 0.0062 0.0323
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0033 0.0087
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0112 0.0261
Entamoeba histolytica protein kinase , putative 0.0072 0.0181 0.1939
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0131 0.0307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0052 0.012 0.0376
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0083 0.0194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.087 0.4015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0118
Schistosoma mansoni hypothetical protein 0.002 0.0019 0.004
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0131 0.041
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0017 0.0037
Leishmania major nonspecific nucleoside hydrolase 0.0118 0.0324 0.1011
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0019 0.0014
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0017 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.007 0.0248
Trypanosoma brucei aurora B kinase 0.0072 0.0181 0.0556
Brugia malayi Pre-SET motif family protein 0.0616 0.1877 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0311 0.0924 0.4919
Trypanosoma cruzi cyclin, putative 0.0021 0.0024 0.007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0186 0.0981
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0152 0.0634
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0078 0.0199 0.1053
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.007 0.296
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0084 0.008
Echinococcus multilocularis serine:threonine protein kinase 0.0102 0.0274 0.027
Onchocerca volvulus 0.0095 0.0251 0.1105
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0075 0.0682
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.0199 0.0856
Schistosoma mansoni tyrosine kinase 0.0265 0.0784 0.1858
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0084 0.0313
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0062 0.0323
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0037 0.0033
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.003 0.5
Brugia malayi tailless protein 0.0019 0.0017 0.0066
Giardia lamblia Hypothetical protein 0.0021 0.0024 0.0075
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0086 0.0195
Toxoplasma gondii AGC kinase 0.0034 0.0062 0.2628
Entamoeba histolytica hypothetical protein 0.0035 0.0066 0.0708
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.003 0.1375
Onchocerca volvulus Huntingtin homolog 0.0123 0.034 0.1521
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0006 0.0014
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0052 0.012 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0083 0.0422
Echinococcus granulosus dna polymerase eta 0.0019 0.0017 0.0031
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0083 0.0194
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0086 0.0324
Schistosoma mansoni lamin 0.0053 0.0123 0.0289
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.0225
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0118
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0217 0.0505
Brugia malayi Muscleblind-like protein 0.0295 0.0877 0.466
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0017 0.007
Echinococcus granulosus tyrosine protein kinase shark 0.0265 0.0784 0.1853
Wolbachia endosymbiont of Brugia malayi dihydroorotase, PyrC 0.0046 0.01 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0017 0.0036
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0217 0.1135
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0021 0.0024 0.0019
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0062 0.0058
Echinococcus multilocularis cyclins 0.0021 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0023
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0045 0.0096
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0017 0.0035
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0062 0.0058
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0062 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0088 0.0232 0.0542
Brugia malayi hypothetical protein 0.0019 0.0017 0.0066
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0019 0.0034
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.003 0.0094
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0163 0.0384
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.087 0.4015
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0167 0.0476 0.253
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.018 0.0565
Echinococcus multilocularis dihydropyrimidinase 2 0.0046 0.01 0.0096
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.013 0.0125
Loa Loa (eye worm) hypothetical protein 0.0072 0.018 0.095
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0052 0.0118 0.0618
Loa Loa (eye worm) hypothetical protein 0.02 0.0581 0.3092
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0466 0.2477
Brugia malayi hypothetical protein 0.0123 0.034 0.1792
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.035 0.0346
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0076 0.0072
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0075 0.3969
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0062 0.0144
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0083 0.0079
Loa Loa (eye worm) glutaminase 2 0.0274 0.0811 0.4318
Brugia malayi serine/threonine-protein kinase 6 0.0072 0.0181 0.0944
Brugia malayi jmjC domain containing protein 0.0059 0.0141 0.0729
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0175 0.0503 0.1185
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0006 0.001
Schistosoma mansoni hypothetical protein 0.0126 0.035 0.0829
Entamoeba histolytica PH domain containing protein kinase, putative 0.0052 0.012 0.1288
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0017 0.0036
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0163 0.0378
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0131 0.069
Entamoeba histolytica hypothetical protein 0.0035 0.0066 0.0708
Echinococcus granulosus serine:threonine protein kinase Chk2 0.005 0.0112 0.0257
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0163 0.0512
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0073 0.026
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0084 0.0425
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0052 0.012 0.0116
Brugia malayi hypothetical protein 0.0035 0.0066 0.033
Brugia malayi nuclear receptor NHR-88 0.0019 0.0017 0.0066
Toxoplasma gondii hypothetical protein 0.0016 0.0008 0.0257
Leishmania major inosine-guanine nucleoside hydrolase, putative 0.0118 0.0324 0.1011
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0274 0.1209
Schistosoma mansoni rab6-interacting 0.002 0.0019 0.004
Entamoeba histolytica protein kinase, putative 0.0072 0.0181 0.1939
Trypanosoma cruzi guanine deaminase, putative 0.0314 0.0934 0.2955
Echinococcus granulosus geminin 0.0507 0.1536 0.3642
Brugia malayi Protein kinase domain containing protein 0.0311 0.0924 0.4912
Mycobacterium ulcerans dihydroorotase 0.0046 0.01 0.0904
Onchocerca volvulus 0.002 0.0019 0.0009
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0019 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0503 0.1191
Mycobacterium tuberculosis Conserved protein 0.0072 0.018 0.1192
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.003 0.123
Onchocerca volvulus 0.0053 0.0123 0.0501
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Trypanosoma brucei cdc2-related kinase 1 0.0056 0.0131 0.0397
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0045 0.0321
Toxoplasma gondii aurora kinase 0.0072 0.0181 0.7774
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0135 0.0377 0.0886
Mycobacterium ulcerans hydroxydechloroatrazine ethylaminohydrolase 0.0314 0.0934 1
Echinococcus multilocularis serine threonine protein kinase 0.0034 0.0062 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0083 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Schistosoma mansoni serine/threonine kinase 0.0078 0.0199 0.0469
Leishmania major protein kinase A catalytic subunit isoform 1 0.0052 0.012 0.0363
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0118 0.0324 0.1445
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0063 0.0152 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.012 0.0282
Entamoeba histolytica Inosine-uridine preferring nucleoside hydrolase, putative 0.0118 0.0324 0.3474
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0045 0.0096
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.007 0.0066
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.087 0.9323
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0083 0.0436
Leishmania major hypothetical protein, conserved 0.0118 0.0324 0.1011
Trypanosoma cruzi dihydroorotase, putative 0.0046 0.01 0.0312
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0056 0.0131 0.0397
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0466 0.0462
Brugia malayi ecdysone receptor 0.0019 0.0017 0.0066
Loa Loa (eye worm) AGC/PKA protein kinase 0.0052 0.012 0.0633
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0017 0.0083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0147 0.0339
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0163 0.0499
Trichomonas vaginalis protein ssnA, putative 0.0314 0.0934 0.4313
Echinococcus granulosus protein kinase C gamma type 0.0034 0.0062 0.0138
Schistosoma mansoni alpha-glucosidase 0.0141 0.0395 0.0935
Leishmania major cyclin 0.0021 0.0024 0.0056
Leishmania major hypothetical protein, conserved 0.0025 0.0033 0.0087
Loa Loa (eye worm) cyclin domain-containing protein 0.0021 0.0024 0.0118
Brugia malayi serine/threonine kinase 12 0.0072 0.0181 0.0944
Loa Loa (eye worm) amidohydrolase 0.0046 0.01 0.0525
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0017 0.0049
Plasmodium vivax JmjC domain containing protein 0.0016 0.0006 0.0258
Echinococcus multilocularis cyclin B 0.0021 0.0024 0.0019
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0175 0.0503 0.1185
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.018 0.1192
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0152 0.0357
Loa Loa (eye worm) beta-lactamase 0.0072 0.018 0.095
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0083 0.0314
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0131 0.0536
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.018 0.0565
Mycobacterium ulcerans urease subunit alpha 0.0046 0.01 0.0904
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0006 0.0002
Schistosoma mansoni hypothetical protein 0.0046 0.01 0.0234
Mycobacterium tuberculosis Conserved protein 0.0046 0.01 0.0607
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.007 0.0749
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0006 0.0004
Echinococcus multilocularis cyclins 0.0021 0.0024 0.0019
Plasmodium falciparum serine/threonine protein kinase, putative 0.0072 0.0181 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0073 0.0162
Echinococcus granulosus cyclin B3 1 0.0021 0.0024 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0147 0.1413
Schistosoma mansoni coup transcription factor 0.0041 0.0083 0.0194
Echinococcus multilocularis cyclins 0.0021 0.0024 0.0019
Leishmania major protein kinase A catalytic subunit 0.0052 0.012 0.0363
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0019 0.0034
Loa Loa (eye worm) hypothetical protein 0.0167 0.0476 0.253
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0396 0.0392
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0063 0.0152 0.0351
Schistosoma mansoni atypical protein kinase C 0.0043 0.0091 0.0212
Loa Loa (eye worm) hypothetical protein 0.0072 0.018 0.095
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0024 0.0019
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0017 0.0079
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0083 0.0079
Leishmania major protein kinase A catalytic subunit isoform 2 0.0052 0.012 0.0363
Onchocerca volvulus 0.0083 0.0217 0.0942
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0006 0.0002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0466 0.0462
Echinococcus granulosus cyclin dependent kinase 1 0.0056 0.0131 0.0302
Echinococcus multilocularis protein kinase c epsilon type 0.0043 0.0091 0.0086
Giardia lamblia Hypothetical protein 0.0118 0.0324 0.3599
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0131 0.1404
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0045 0.2212
Mycobacterium ulcerans glutaminase 0.0274 0.0811 0.8665
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0062 0.0138
Entamoeba histolytica protein kinase domain containing protein 0.0072 0.0181 0.1939
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.018 0.1774
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0163 0.0849
Schistosoma mansoni dihydropyrimidinase related protein-2 (M38 family) 0.0046 0.01 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0083 0.0422
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0006 0.0002
Brugia malayi cell division control protein 2 homolog 0.0056 0.0131 0.0677
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0033 0.1566
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0083 0.0422
Echinococcus granulosus tumor protein p63 0.0339 0.1013 0.2399
Onchocerca volvulus 0.005 0.0112 0.0447
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0118
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0436
Loa Loa (eye worm) hypothetical protein 0.0052 0.012 0.0633
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0175 0.0503 0.0499
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0123 0.0635
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.007 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0118
Onchocerca volvulus 0.0072 0.018 0.0768
Plasmodium vivax dihydroorotase, putative 0.0046 0.01 0.431
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0147 0.0345
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0056 0.0131 0.069
Echinococcus multilocularis tyrosine protein kinase shark 0.0265 0.0784 0.078
Schistosoma mansoni lamin 0.0053 0.0123 0.0289
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0181 0.0426
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0131 0.0127
Leishmania major guanine deaminase, putative 0.0314 0.0934 0.2945
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.087 0.9323
Echinococcus multilocularis geminin 0.0507 0.1536 0.1532
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.018 0.0765
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0017 0.0012
Entamoeba histolytica cyclin family protein 0.0021 0.0024 0.0254
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0396 0.2094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0083 0.0194
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0141 0.0325
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0199 0.0469
Brugia malayi Cyclin, N-terminal domain containing protein 0.029 0.0861 0.4575
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0135 0.0377 0.2001
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0052 0.012 0.0276
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0031 0.1273
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0131 0.0536
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0017 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0017 0.0049
Trypanosoma brucei guanine deaminase, putative 0.0314 0.0934 0.2945
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0466 0.2467
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0163 0.0499
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0072 0.0181 0.1939
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0066 0.0153
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.0211
Trypanosoma cruzi CYC2-like cyclin, putative 0.0021 0.0024 0.007
Mycobacterium ulcerans beta-lactamase 0.0072 0.018 0.1774
Plasmodium vivax protein kinase Crk2 0.0056 0.0131 0.5643
Toxoplasma gondii ABC1 family protein 0.0072 0.018 0.7726
Brugia malayi Protein kinase domain containing protein 0.0078 0.0199 0.1041
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0052 0.012 0.0276
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0131 0.1334
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0062 0.0138
Brugia malayi hypothetical protein 0.0025 0.0033 0.0156
Schistosoma mansoni hypothetical protein 0.0073 0.0186 0.0437
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0083 0.0422
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.018 0.0552
Loa Loa (eye worm) cyclin domain-containing protein 0.029 0.0861 0.4582
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0163 0.0862
Loa Loa (eye worm) hypothetical protein 0.0072 0.018 0.095
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.003 0.0139
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.009
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0091 0.0212
Brugia malayi p70 ribosomal S6 kinase beta 0.0034 0.0062 0.031
Brugia malayi protein kinase C II. 0.0043 0.0091 0.0462
Loa Loa (eye worm) hypothetical protein 0.0072 0.018 0.095
Echinococcus multilocularis muscleblind protein 1 0.0295 0.0877 0.0873
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0006 0.0004
Echinococcus granulosus protein tyrosine kinase 0.0307 0.0913 0.216
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0083 0.0194
Echinococcus granulosus serine:threonine protein kinase 0.0102 0.0274 0.0642
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0083 0.0188
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0015 0.0004 0.0014
Trichomonas vaginalis cyclins, putative 0.0021 0.0024 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0083 0.0194
Loa Loa (eye worm) DR-78 0.0019 0.0017 0.0079
Loa Loa (eye worm) RecQ helicase 0.0041 0.0084 0.0438
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0141 0.0331
Schistosoma mansoni tyrosine kinase 0.0259 0.0765 0.1813
Onchocerca volvulus 0.002 0.0019 0.0009
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0073 0.0162
Giardia lamblia Kinase, AGC PKA 0.0052 0.012 0.1207
Brugia malayi nuclear receptor NHR-88 0.0041 0.0083 0.0422
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0088 0.0232 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0017 0.0049
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0073 0.0068
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0072 0.0181 0.0177
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0181 0.077
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.1381 1
Echinococcus multilocularis cyclins 0.0021 0.0024 0.0019
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0102 0.0274 0.1453
Trichomonas vaginalis hypothetical protein 0.0046 0.01 0.039
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0073 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0083 0.0188
Brugia malayi intermediate filament protein 0.0053 0.0123 0.0635
Schistosoma mansoni dihydropyrimidinase (M38 family) 0.0046 0.01 0.0234
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0062 0.0323
Entamoeba histolytica protein kinase, putative 0.005 0.0112 0.1202
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0006 0.0002
Schistosoma mansoni cyclins 0.0021 0.0024 0.0052
Trypanosoma cruzi guanine deaminase, putative 0.0314 0.0934 0.2955
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.018 0.0423
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0083 0.0188
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0053 0.0566
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0141 0.0325
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Schistosoma mansoni tyrosine kinase 0.0307 0.0913 0.2165
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0006 0.0005
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0072 0.0181 0.042
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0083 0.0079
Brugia malayi nuclear hormone receptor 0.0019 0.0017 0.0066
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0017 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Schistosoma mansoni microtubule-associated protein tau 0.1366 0.421 1
Brugia malayi hypothetical protein 0.0016 0.0006 0.0011
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0062 0.0058
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0175 0.0503 0.0499
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.003 0.0076
Loa Loa (eye worm) hypothetical protein 0.0167 0.0476 0.253
Mycobacterium tuberculosis Probable nucleoside hydrolase IunH (purine nucleosidase) 0.0118 0.0324 0.2252
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0083 0.0314
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0086 0.3665
Toxoplasma gondii AGC kinase 0.0052 0.012 0.5142
Loa Loa (eye worm) hypothetical protein 0.0072 0.018 0.095
Brugia malayi beta-lactamase 0.0072 0.018 0.0938
Trichomonas vaginalis cyclin D, putative 0.0021 0.0024 0.003
Echinococcus multilocularis dihydropyrimidinase 0.0046 0.01 0.0096
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0083 0.0194
Brugia malayi Protein kinase domain containing protein 0.0034 0.0062 0.031
Trypanosoma cruzi dihydroorotase, putative 0.0046 0.01 0.0312
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.018 0.0765
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0222 0.0518
Echinococcus multilocularis protein tyrosine kinase 0.0307 0.0913 0.0909
Trichomonas vaginalis cyclin B, putative 0.0021 0.0024 0.003
Brugia malayi nuclear receptor RXR 0.0019 0.0017 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0466 0.1098
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.007 0.0216
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0163 0.0512
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0006 0.0004
Schistosoma mansoni intermediate filament proteins 0.0053 0.0123 0.0289
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.0598 0.1417
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0169
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.018 0.0418
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.005 0.0112 0.0108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.087 0.4015
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Plasmodium falciparum cyclin 0.0021 0.0024 0.1013
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.0107 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0112 0.0263
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.0322
Echinococcus granulosus bloom syndrome protein 0.0041 0.0084 0.0189
Echinococcus granulosus RUN 0.002 0.0019 0.0034
Trypanosoma cruzi inosine-guanine nucleoside hydrolase, putative 0.0118 0.0324 0.1023
Echinococcus granulosus cyclins 0.0021 0.0024 0.0046
Mycobacterium ulcerans n-acetylglucosamine-6-phosphate deacetylase NagA 0.0046 0.01 0.0904
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0073 0.0168
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0052 0.012 0.0376
Mycobacterium tuberculosis Urease alpha subunit UreC (urea amidohydrolase) 0.0046 0.01 0.0607
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0076 0.0172
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0083 0.0422
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0024 0.0104
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0053 0.0162
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0045 0.0229
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.007 0.0248
Trichomonas vaginalis cyclin B, putative 0.0021 0.0024 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0066 0.0147
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0017 0.0029
Brugia malayi steroid hormone receptor 0.0041 0.0083 0.0422
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0052 0.012 0.0363
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.003 0.0139
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.018 0.1192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0083 0.0422
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0173
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0017 0.0013
Echinococcus granulosus cyclins 0.0021 0.0024 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0083 0.0422
Schistosoma mansoni alpha glucosidase 0.0036 0.007 0.0162
Leishmania major hypothetical protein, conserved 0.0072 0.018 0.0552
Echinococcus granulosus cyclins 0.0021 0.0024 0.0046
Brugia malayi hypothetical protein 0.002 0.0019 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0062 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0024 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0019 0.0014
Brugia malayi phosphoinositide-dependent protein kinase I 0.0063 0.0152 0.0789
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0024 0.0052
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0073 0.0162
Loa Loa (eye worm) hypothetical protein 0.0295 0.0877 0.4667
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0083 0.0314
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0131 0.069
Trichomonas vaginalis aminohydrolase, putative 0.0046 0.01 0.039
Schistosoma mansoni protein kinase 0.0072 0.0181 0.0426
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0086 0.3665
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0141 0.0331
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0083 0.0188
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0017 0.0036
Entamoeba histolytica PH domain containing protein kinase, putative 0.0052 0.012 0.1288
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0141 0.0137
Trichomonas vaginalis hypothetical protein 0.0118 0.0324 0.1445
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0199 0.0469
Schistosoma mansoni hypothetical protein 0.0073 0.0186 0.0437
Plasmodium vivax hypothetical protein, conserved 0.0072 0.018 0.7743
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0006 0.0186
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0083 0.0079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0083 0.0188
Brugia malayi Protein kinase domain containing protein 0.0034 0.0062 0.031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0083 0.0079
Loa Loa (eye worm) AGC/PKA protein kinase 0.0052 0.012 0.0633
Trichomonas vaginalis glutaminase, putative 0.0274 0.0811 0.3737
Schistosoma mansoni zinc finger protein 0.0019 0.0017 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0181 0.077
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.007 0.0248
Schistosoma mansoni dihydropyrimidinase (M38 family) 0.0046 0.01 0.0234
Echinococcus granulosus dihydropyrimidinase protein 4 0.0046 0.01 0.0228
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0086 0.3711
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0217 0.0213
Trichomonas vaginalis cyclin B, putative 0.0021 0.0024 0.003
Trichomonas vaginalis set domain proteins, putative 0.0702 0.2142 1
Echinococcus multilocularis tumor protein p63 0.0339 0.1013 0.1009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Onchocerca volvulus Huntingtin homolog 0.0123 0.034 0.1521
Leishmania major N-acetylglucosamine-6-phosphate deacetylase-like protein 0.0046 0.01 0.0299
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.087 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0147 0.6289
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0147 0.0345
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0141 0.0742
Echinococcus multilocularis microtubule associated protein 2 0.1366 0.421 0.4207
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0017 0.0035
Onchocerca volvulus 0.0072 0.018 0.0768
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0083 0.0436
Giardia lamblia Kinase, AGC AKT 0.0105 0.0285 0.314
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0024 0.0104
Entamoeba histolytica D-hydantoinase, putative 0.0046 0.01 0.1073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0083 0.0422
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0083 0.0188
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.018 0.095
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0017 0.0036
Brugia malayi nuclear receptor RXR 0.0021 0.0024 0.0104
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0017 0.0066
Entamoeba histolytica protein kinase, putative 0.005 0.0112 0.1202
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0083 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0232 0.0548
Entamoeba histolytica cyclin, putative 0.0021 0.0024 0.0254
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0006 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.018 0.1192
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.087 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0063 0.0316
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.018 0.0765
Entamoeba histolytica recQ family DNA helicase 0.0014 0.0002 0.0018
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0076 0.3987
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0113 0.058
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0056 0.0131 0.5611
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.018 0.1774
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0181 0.0956
Brugia malayi jmjC domain containing protein 0.0059 0.0141 0.0729
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0017 0.0012
Brugia malayi Amidohydrolase family protein 0.0046 0.01 0.0512
Echinococcus granulosus Protein kinase C brain isozyme 0.0043 0.0091 0.0206
Trichomonas vaginalis cyclin A, putative 0.0021 0.0024 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0616 0.1877 1
Trichomonas vaginalis cyclin B3, putative 0.0021 0.0024 0.003
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0045 0.0216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.087 0.4015
Leishmania major protein kinase, putative 0.0072 0.0181 0.0556
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.0062 0.0323
Schistosoma mansoni aspartate carbamoyltransferase 0.0046 0.01 0.0234
Echinococcus multilocularis RUN 0.002 0.0019 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0083 0.0194
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0141 0.0331
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0118
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0072 0.0181 0.1939
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0083 0.0436
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0019 0.0801
Echinococcus multilocularis cyclins 0.0021 0.0024 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0083 0.0079
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0017 0.0012
Echinococcus granulosus cyclins 0.0021 0.0024 0.0046
Loa Loa (eye worm) hypothetical protein 0.0102 0.0274 0.1453
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0181 0.0956
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0017 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0006 0.0011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.018 0.0938
Brugia malayi Protein kinase domain containing protein 0.0034 0.0062 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0083 0.0436
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Trypanosoma cruzi imidazolonepropionase, putative 0.0046 0.01 0.0312
Brugia malayi Protein kinase domain containing protein 0.0063 0.0152 0.0789
Loa Loa (eye worm) doublecortin family protein 0.002 0.0019 0.009
Trypanosoma brucei inosine-guanine nucleoside hydrolase 0.0118 0.0324 0.1011
Echinococcus multilocularis dna polymerase eta 0.0019 0.0017 0.0013
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0039 0.0089
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0046 0.0223
Schistosoma mansoni DNA helicase recq1 0.0028 0.0045 0.0102
Echinococcus granulosus protein kinase c iota type 0.0043 0.0091 0.0206
Mycobacterium ulcerans hypothetical protein 0.0046 0.01 0.0904
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0147 0.0143
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.003 0.123
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0324 0.1023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.087 0.4015
Echinococcus granulosus microtubule associated protein 2 0.1366 0.421 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.007 0.0351
Echinococcus granulosus cyclin b3 0.0021 0.0024 0.0046
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0384 0.0903
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.1027 0.3155 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0017 0.0029
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0011
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0053 0.0167
Entamoeba histolytica protein kinase, putative 0.0034 0.0062 0.0667
Echinococcus multilocularis lamin dm0 0.0053 0.0123 0.0119
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0024 0.0052
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0083 0.0188
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0105 0.0285 0.15
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0017 0.0012
Schistosoma mansoni alpha-glucosidase 0.0141 0.0395 0.0935
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0017 0.0029
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0006 0.001
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0062 0.0323
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0063 0.0152 0.0802
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.012 0.0282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Brugia malayi Pre-SET motif family protein 0.0088 0.0232 0.1218
Echinococcus granulosus lamin 0.0053 0.0123 0.0283
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0017 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0083 0.0422
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.007 0.0248
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0045 0.0216
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.007 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0083 0.0422
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0017 0.0037
Schistosoma mansoni hypothetical protein 0.0507 0.1536 0.3646
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0113 0.058
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.0004 0.0006
Trichomonas vaginalis guanine deaminase, putative 0.0314 0.0934 0.4313
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0045 0.0229
Brugia malayi Doublecortin family protein 0.002 0.0019 0.0077
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0006 0.0186
Entamoeba histolytica cyclin family protein 0.0021 0.0024 0.0254
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0045 0.004
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0073 0.0211
Schistosoma mansoni nuclear receptor 0.0019 0.0017 0.0035
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0217 0.0511
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0052 0.012 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0083 0.0194
Brugia malayi hypothetical protein 0.0019 0.0017 0.0066
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0033 0.1566
Trichomonas vaginalis cyclin B, putative 0.0021 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0436
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0037 0.0078
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.007 0.0248
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0052 0.012 0.0363
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0006 0.001
Schistosoma mansoni thyroid hormone receptor 0.0167 0.0477 0.1129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0052 0.012 0.5142
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0436
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0079
Echinococcus multilocularis lamin 0.0053 0.0123 0.0119
Entamoeba histolytica guanine deaminase, putative 0.0314 0.0934 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.007 0.0216
Schistosoma mansoni hypothetical protein 0.0035 0.0066 0.0153
Brugia malayi ecdysteroid receptor 0.0041 0.0083 0.0422
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Echinococcus granulosus dihydropyrimidinase 0.0046 0.01 0.0228
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0062 0.0212
Trypanosoma brucei cdc2-related kinase 3 0.0056 0.0131 0.0397
Toxoplasma gondii AGC kinase 0.0052 0.012 0.5142
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0403 0.283
Onchocerca volvulus 0.0167 0.0476 0.2162
Brugia malayi beta-lactamase family protein 0.0072 0.018 0.0938
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0131 0.0536
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0017 0.0036
Echinococcus multilocularis muscleblind protein 0.0295 0.0877 0.0873
Mycobacterium ulcerans imidazolonepropionase 0.0046 0.01 0.0904
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0062 0.0323
Brugia malayi Cyclin, N-terminal domain containing protein 0.0021 0.0024 0.0104
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0017 0.0066
Brugia malayi Kinase associated domain 1 family protein 0.0073 0.0186 0.0969
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0073 0.0648
Entamoeba histolytica hypothetical protein 0.0035 0.0066 0.0708
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0052 0.012 0.5178
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0006 0.001
Echinococcus multilocularis cyclin B3 1 0.0021 0.0024 0.0019
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0163 0.0159
Echinococcus multilocularis cyclin dependent kinase 5 0.0056 0.0131 0.0127

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 5 mM Cell cycle arrest in human HeLa cells assessed as accumulation at S phase ChEMBL. 18077363
Activity (functional) = 5 mM Cell cycle arrest in human HeLa cells assessed as accumulation at S phase ChEMBL. 18077363
IC50 (binding) = 300000 nM Inhibition of p34cdc2/cyclin B (unknown origin) ChEMBL. 18077363
IC50 (binding) = 218 uM Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site ChEMBL. 2165159
IC50 (binding) = 218 uM Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site ChEMBL. 2165159
Inhibition (binding) > 30 % Inhibition of ASK1 assessed as phosphorylated fluorescent peptide at 10 uM by mobility shift assay ChEMBL. 21134755
Inhibition (binding) = 57 % The percent inhibition of [3H]-diazepam binding to the benzodiazepine receptor of rat brain elicited by 100 microM of compound ChEMBL. 2540330
Inhibition (binding) = 57 % The percent inhibition of [3H]-diazepam binding to the benzodiazepine receptor of rat brain elicited by 100 microM of compound ChEMBL. 2540330
Ki (functional) = 4.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 4.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCD ChEMBL. No reference
Ki (functional) = 4.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CHEK1 ChEMBL. No reference
Ki (binding) > 5 Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysis ChEMBL. 22289061
Ki (binding) > 5 Inhibition of human recombinant PYK2 by ESI-MS analysis ChEMBL. 22289061
Ki (functional) = 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MARK2 ChEMBL. No reference
Ki (functional) = 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PDPK1 ChEMBL. No reference
Ki (functional) = 5.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: RPS6KA3 ChEMBL. No reference
Ki (functional) = 5.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MARK3 ChEMBL. No reference
Ki (functional) = 5.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK6 ChEMBL. No reference
Ki (functional) = 5.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CHEK2 ChEMBL. No reference
Ki (binding) = 5.96 Inhibition of human recombinant CDK2/CycE using HHASPRK as substrate by ESI-MS analysis ChEMBL. 22289061
Ki (binding) = 150.2 uM Binding affinity (Ki) against human phosphatidylinositol 4-kinase ChEMBL. 2165159
Ki (binding) = 150.2 uM Binding affinity (Ki) against human phosphatidylinositol 4-kinase ChEMBL. 2165159
Thermal melting change (binding) = -1 degrees C Delta TM value showing the stabilisation of VRK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.6 degrees C Delta TM value showing the stabilisation of AMPKA2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.4 degrees C Delta TM value showing the stabilisation of LOK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.3 degrees C Delta TM value showing the stabilisation of PAK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.3 degrees C Delta TM value showing the stabilisation of PCTK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.2 degrees C Delta TM value showing the stabilisation of CAMK2D produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.2 degrees C Delta TM value showing the stabilisation of MEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of CAMK1G produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of CK1G1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of ERK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of CAMK1D produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of CAMK2B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of CAMK2G produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of CDKL1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of NEK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of PAK5 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of PIM1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of MST4 (2) produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of TNIK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of VRK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of VRK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of CAMK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of CDK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of p38beta produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of MST4(1) produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of PDK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of RIOK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.2 degrees C Delta TM value showing the stabilisation of MAP2K6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.3 degrees C Delta TM value showing the stabilisation of CDK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.3 degrees C Delta TM value showing the stabilisation of PIM2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.3 degrees C Delta TM value showing the stabilisation of NDR1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.4 degrees C Delta TM value showing the stabilisation of CLK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.4 degrees C Delta TM value showing the stabilisation of ERK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of CHEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of CK1G2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of CK1G3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of PAK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of PLK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of MPSK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of PBK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.6 degrees C Delta TM value showing the stabilisation of RSK2a produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.7 degrees C Delta TM value showing the stabilisation of GSK3B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.7 degrees C Delta TM value showing the stabilisation of PRKACA produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.8 degrees C Delta TM value showing the stabilisation of DMPK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.8 degrees C Delta TM value showing the stabilisation of NEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.8 degrees C Delta TM value showing the stabilisation of RSK2b produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.8 degrees C Delta TM value showing the stabilisation of SLK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.9 degrees C Delta TM value showing the stabilisation of CLK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.9 degrees C Delta TM value showing the stabilisation of DAPK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.9 degrees C Delta TM value showing the stabilisation of JAK1~B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.9 degrees C Delta TM value showing the stabilisation of PIM3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.9 degrees C Delta TM value showing the stabilisation of YSK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1 degrees C Delta TM value showing the stabilisation of CAMKK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.1 degrees C Delta TM value showing the stabilisation of OSR1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.1 degrees C Delta TM value showing the stabilisation of MST1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.3 degrees C Delta TM value showing the stabilisation of CLK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.3 degrees C Delta TM value showing the stabilisation of PLK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.5 degrees C Delta TM value showing the stabilisation of DRAK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.7 degrees C Delta TM value showing the stabilisation of CAMK2A produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.8 degrees C Delta TM value showing the stabilisation of ASK1 produced by compound binding ChEMBL. 18077363

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

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