Detailed information for compound 56063

Basic information

Technical information
  • TDR Targets ID: 56063
  • Name: N-[4-[5-[[3-(2-dimethylaminoethyl)-1H-indol-5 -yl]methyl]-1,2,4-oxadiazol-3-yl]phenyl]metha nesulfonamide
  • MW: 439.531 | Formula: C22H25N5O3S
  • H donors: 2 H acceptors: 4 LogP: 3.15 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCc1c[nH]c2c1cc(cc2)Cc1onc(n1)c1ccc(cc1)NS(=O)(=O)C)C
  • InChi: 1S/C22H25N5O3S/c1-27(2)11-10-17-14-23-20-9-4-15(12-19(17)20)13-21-24-22(25-30-21)16-5-7-18(8-6-16)26-31(3,28)29/h4-9,12,14,23,26H,10-11,13H2,1-3H3
  • InChiKey: YIRZCLCPNKBHHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Serotonin 1d (5-HT1d) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi neuropeptide F receptor Serotonin 1d (5-HT1d) receptor   291 aa 289 aa 22.8 %
Echinococcus multilocularis neuropeptide receptor Serotonin 1d (5-HT1d) receptor   291 aa 302 aa 22.8 %
Schistosoma japonicum Neuropeptide FF receptor 2, putative Serotonin 1d (5-HT1d) receptor   291 aa 243 aa 21.8 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 289 aa 22.8 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 319 aa 33.9 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 1d (5-HT1d) receptor   291 aa 313 aa 35.8 %
Schistosoma mansoni neuropeptide receptor Serotonin 1d (5-HT1d) receptor   291 aa 302 aa 23.5 %
Schistosoma mansoni amine GPCR Serotonin 1d (5-HT1d) receptor   291 aa 271 aa 20.7 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Serotonin 1d (5-HT1d) receptor   291 aa 292 aa 24.0 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1d (5-HT1d) receptor   291 aa 293 aa 37.2 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 1d (5-HT1d) receptor   291 aa 304 aa 20.7 %
Echinococcus multilocularis serotonin receptor Serotonin 1d (5-HT1d) receptor   291 aa 348 aa 23.3 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Serotonin 1d (5-HT1d) receptor   291 aa 300 aa 36.0 %
Onchocerca volvulus Cullin-4 homolog Serotonin 1d (5-HT1d) receptor   291 aa 256 aa 25.4 %
Loa Loa (eye worm) neuropeptide F receptor Serotonin 1d (5-HT1d) receptor   291 aa 318 aa 20.4 %
Schistosoma mansoni neuropeptide receptor Serotonin 1d (5-HT1d) receptor   291 aa 304 aa 21.1 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 340 aa 37.1 %
Echinococcus multilocularis neuropeptide Y receptor Serotonin 1d (5-HT1d) receptor   291 aa 300 aa 22.7 %
Schistosoma mansoni opsin-like receptor Serotonin 1d (5-HT1d) receptor   291 aa 295 aa 22.0 %
Schistosoma mansoni dro/myosuppressin receptor Serotonin 1d (5-HT1d) receptor   291 aa 247 aa 23.9 %
Schistosoma japonicum Rhodopsin, putative Serotonin 1d (5-HT1d) receptor   291 aa 253 aa 21.7 %
Echinococcus granulosus biogenic amine 5HT receptor Serotonin 1d (5-HT1d) receptor   291 aa 359 aa 32.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1d (5-HT1d) receptor   291 aa 323 aa 32.2 %
Echinococcus granulosus g protein coupled receptor Serotonin 1d (5-HT1d) receptor   291 aa 354 aa 21.5 %
Schistosoma mansoni amine GPCR Serotonin 1d (5-HT1d) receptor   291 aa 358 aa 32.1 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 348 aa 20.4 %
Schistosoma mansoni adenoreceptor Serotonin 1d (5-HT1d) receptor   291 aa 292 aa 28.4 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 357 aa 32.8 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1d (5-HT1d) receptor   291 aa 354 aa 22.0 %
Loa Loa (eye worm) hypothetical protein Serotonin 1d (5-HT1d) receptor   291 aa 278 aa 24.1 %
Loa Loa (eye worm) hypothetical protein Serotonin 1d (5-HT1d) receptor   291 aa 301 aa 23.3 %
Brugia malayi GnHR receptor homolog Serotonin 1d (5-HT1d) receptor   291 aa 306 aa 20.6 %
Echinococcus granulosus neuropeptide receptor Serotonin 1d (5-HT1d) receptor   291 aa 302 aa 22.8 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1d (5-HT1d) receptor   291 aa 292 aa 19.9 %
Brugia malayi neuropeptide F receptor Serotonin 1d (5-HT1d) receptor   291 aa 281 aa 21.0 %
Loa Loa (eye worm) hypothetical protein Serotonin 1d (5-HT1d) receptor   291 aa 321 aa 27.4 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1d (5-HT1d) receptor   291 aa 312 aa 26.3 %
Loa Loa (eye worm) neuropeptide F receptor Serotonin 1d (5-HT1d) receptor   291 aa 260 aa 21.2 %
Echinococcus multilocularis somatostatin receptor Serotonin 1d (5-HT1d) receptor   291 aa 287 aa 19.5 %
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Serotonin 1d (5-HT1d) receptor   291 aa 284 aa 34.2 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1d (5-HT1d) receptor   291 aa 349 aa 28.1 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 345 aa 25.2 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1d (5-HT1d) receptor   291 aa 363 aa 18.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1d (5-HT1d) receptor   291 aa 334 aa 31.7 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 305 aa 21.3 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 1d (5-HT1d) receptor   291 aa 292 aa 23.3 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 265 aa 21.9 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Serotonin 1d (5-HT1d) receptor   291 aa 301 aa 27.9 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Serotonin 1d (5-HT1d) receptor   291 aa 336 aa 25.9 %
Loa Loa (eye worm) hypothetical protein Serotonin 1d (5-HT1d) receptor   291 aa 297 aa 25.3 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Serotonin 1d (5-HT1d) receptor   291 aa 296 aa 32.4 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Serotonin 1d (5-HT1d) receptor   291 aa 259 aa 25.5 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1d (5-HT1d) receptor   291 aa 315 aa 26.7 %
Onchocerca volvulus Diphthamide biosynthesis protein 1 homolog Serotonin 1d (5-HT1d) receptor   291 aa 293 aa 24.9 %
Brugia malayi Tachykinin-like peptides receptor 99D Serotonin 1d (5-HT1d) receptor   291 aa 278 aa 23.4 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 297 aa 21.5 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 376 aa 21.5 %
Brugia malayi sulfakinin receptor protein Serotonin 1d (5-HT1d) receptor   291 aa 346 aa 24.3 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 1d (5-HT1d) receptor   291 aa 291 aa 23.0 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 291 aa 23.7 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Serotonin 1d (5-HT1d) receptor   291 aa 318 aa 32.1 %
Onchocerca volvulus Serotonin 1d (5-HT1d) receptor   291 aa 313 aa 36.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0114 0.0563 0.3828
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0033 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Brugia malayi Cathepsin L-like precursor 0.0025 0.0038 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Schistosoma mansoni hypothetical protein 0.0269 0.1485 0.1485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0009 0.0009
Brugia malayi neuroendocrine convertase 1 precursor 0.0053 0.0201 0.0201
Trichomonas vaginalis abcb9, putative 0.0021 0.0015 0.0101
Echinococcus multilocularis calpain 7 (C02 family) 0.0081 0.037 0.0661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Schistosoma mansoni calpain (C02 family) 0.0081 0.037 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.016 0.016
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0081 0.037 0.0661
Brugia malayi Cathepsin L-like precursor 0.002 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0005 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0025 0.0038 0.0038
Leishmania major hypothetical protein, unknown function 0.0024 0.0033 0.0059
Schistosoma mansoni calpain-2 (C02 family) 0.0024 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0101
Echinococcus multilocularis fmrfamide receptor 0.002 0.0009 0.0017
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0391 0.2209 0.3949
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus cathepsin l cysteine peptidase 0.0025 0.0038 0.0068
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0033 0.0059
Toxoplasma gondii microneme protein MIC17C 0.0034 0.0089 0.0133
Echinococcus multilocularis g protein coupled receptor 0.002 0.0009 0.0017
Trypanosoma brucei Calpain-like protein 1.1 0.0024 0.0033 0.0059
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Toxoplasma gondii subtilisin SUB11 0.0053 0.0201 0.0333
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0015 0.0101
Entamoeba histolytica protein kinase, putative 0.0057 0.0225 0.3993
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.032 0.0572
Schistosoma mansoni myosin xvIII 0.002 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.032 0.0572
Brugia malayi MH2 domain containing protein 0.0033 0.0081 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0009 0.0009
Brugia malayi beta-lactamase 0.0036 0.0101 0.0101
Schistosoma mansoni Smad4 0.0033 0.0081 0.0081
Onchocerca volvulus 0.0036 0.0101 0.0173
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.005 0.0648
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0009 0.0017
Toxoplasma gondii hypothetical protein 0.0024 0.0033 0.0033
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0009 0.0017
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0009 0.0017
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0015 0.0101
Trypanosoma brucei calpain-like protein, putative 0.0081 0.037 0.0661
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0038 0.0059
Onchocerca volvulus 0.0034 0.0089 0.015
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.037 0.0661
Toxoplasma gondii aspartyl protease ASP3 0.0091 0.0429 0.0743
Onchocerca volvulus 0.002 0.0009 0.0008
Echinococcus granulosus inhibitor of apoptosis protein 0.0269 0.1485 0.2655
Giardia lamblia Alanyl dipeptidyl peptidase 0.0114 0.0563 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0114 0.0563 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Plasmodium falciparum plasmepsin IX 0.0091 0.0429 0.7557
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0009 0.0009
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0053 0.0201 0.0408
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0009 0.0017
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0009 0.0017
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0009 0.0009
Leishmania major p-glycoprotein 0.0021 0.0015 0.0027
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0101
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0281 0.1556 0.1556
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0009 0.0009
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0038 0.0068
Brugia malayi larval opioid receptor 0.002 0.0009 0.0009
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0161 0.0841 0.1502
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0009 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Trypanosoma brucei calpain-like protein, putative 0.0081 0.037 0.0661
Leishmania major prefoldin subunit, putative 0.0031 0.007 0.0124
Echinococcus multilocularis neuropeptide receptor 0.002 0.0009 0.0017
Trichomonas vaginalis calpain, putative 0.0024 0.0033 0.0224
Brugia malayi G protein-coupled receptor 0.002 0.0009 0.0009
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0015 0.0027
Brugia malayi nuclear hormone receptor 0.002 0.0009 0.0009
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0009 0.0009
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0053 0.0201 0.0408
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Onchocerca volvulus 0.002 0.0009 0.0008
Echinococcus multilocularis g protein coupled receptor 0.002 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0333 0.1863 0.1863
Giardia lamblia Cathepsin B precursor 0.0095 0.0451 0.8006
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0088 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0101
Loa Loa (eye worm) cathepsin B 0.0095 0.0451 0.0451
Brugia malayi Trypsin family protein 0.0066 0.0277 0.0277
Toxoplasma gondii subtilisin SUB7 0.0053 0.0201 0.0333
Plasmodium falciparum cysteine proteinase falcipain 3 0.0025 0.0038 0.0424
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0265 0.0473
Loa Loa (eye worm) hypothetical protein 0.0158 0.0828 0.0828
Loa Loa (eye worm) MH2 domain-containing protein 0.0478 0.2723 0.2723
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0015 0.0101
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0009 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.016 0.0286
Schistosoma mansoni hypothetical protein 0.0165 0.087 0.087
Echinococcus granulosus g protein coupled receptor 0.002 0.0009 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0076 0.0338 0.0338
Brugia malayi steroid hormone receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Onchocerca volvulus 0.0034 0.0089 0.015
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0015 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0101 0.0101
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0034 0.0089 0.0133
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0053 0.0201 0.0358
Schistosoma mansoni P2X receptor subunit 0.0067 0.0283 0.0283
Schistosoma mansoni site-1 peptidase (S08 family) 0.0053 0.0201 0.0201
Onchocerca volvulus 0.0267 0.1472 0.2624
Trypanosoma cruzi oligopeptidase b 0.0391 0.2209 0.3949
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Onchocerca volvulus Prolyl endopeptidase homolog 0.0962 0.5595 1
Echinococcus granulosus calpain A 0.0081 0.037 0.0661
Entamoeba histolytica prolyl oligopeptidase family protein 0.0114 0.0563 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.0161 0.0841 0.1502
Trypanosoma brucei prolyl oligopeptidase, putative 0.0391 0.2209 0.3949
Schistosoma mansoni neuropeptide receptor 0.002 0.0009 0.0009
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.005 0.009
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0053 0.0201 0.0538
Schistosoma mansoni amine GPCR 0.002 0.0009 0.0009
Onchocerca volvulus 0.0066 0.0277 0.0487
Echinococcus granulosus somatostatin receptor 0.002 0.0009 0.0017
Schistosoma mansoni neuropeptide receptor 0.002 0.0009 0.0009
Trichomonas vaginalis calpain, putative 0.0024 0.0033 0.0224
Echinococcus granulosus hypothetical protein 0.002 0.0009 0.0017
Onchocerca volvulus 0.0021 0.0015 0.0018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0009 0.0016
Echinococcus granulosus calpain 0.0081 0.037 0.0661
Plasmodium vivax aspartyl protease, putative 0.0091 0.0429 0.7557
Echinococcus multilocularis prefoldin subunit 6 0.0031 0.007 0.0124
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0009 0.0017
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0009 0.0017
Leishmania major hypothetical protein, conserved 0.0027 0.005 0.009
Brugia malayi calpain family protein 1 0.0215 0.1164 0.1164
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0009 0.0017
Echinococcus granulosus glycoprotein Antigen 5 0.0066 0.0277 0.0496
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0238 0.0426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Trypanosoma brucei cysteine peptidase C (CPC) 0.0095 0.0451 0.0806
Plasmodium vivax subtilisin-like protease 1 0.0053 0.0201 0.3386
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.005 0.0648
Entamoeba histolytica prefoldin subunit 6, putative 0.0031 0.007 0.1236
Plasmodium falciparum subtilisin-like protease 1 0.0053 0.0201 0.3386
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0281 0.1556 0.2781
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0269 0.1485 0.2655
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0249 0.0445
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0009 0.0017
Onchocerca volvulus 0.002 0.0009 0.0007
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0024 0.0033 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0015 0.0263
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Brugia malayi nuclear receptor NHR-88 0.002 0.0009 0.0009
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0015 0.0027
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0015 0.0027
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0009 0.0017
Toxoplasma gondii prolyl endopeptidase 0.0962 0.5595 1
Toxoplasma gondii subtilisin SUB4 0.0053 0.0201 0.0333
Onchocerca volvulus 0.0034 0.0088 0.0148
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0015 0.0027
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0053 0.0201 0.0648
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0563 0.3828
Echinococcus granulosus tar DNA binding protein 0.0063 0.0265 0.0473
Trypanosoma brucei calpain, putative 0.0024 0.0033 0.0059
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0962 0.5595 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0009 0.0009
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0009 0.0017
Echinococcus multilocularis tissue type plasminogen activator 0.0076 0.0338 0.0605
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0215 0.1164 0.1164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0053 0.0201 0.0201
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0249 0.0445
Trypanosoma brucei hypothetical protein 0.0024 0.0033 0.0059
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0009 0.0017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0009 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0196
Leishmania major cathepsin L-like protease 0.0025 0.0038 0.0068
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0053 0.0201 0.0358
Onchocerca volvulus 0.0244 0.1333 0.2376
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0088 0.0088
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0962 0.5595 0.5595
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0265 0.0265
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Onchocerca volvulus 0.0066 0.0277 0.0487
Schistosoma mansoni ets-related 0.0238 0.1302 0.1302
Echinococcus granulosus geminin 0.0165 0.087 0.1554
Brugia malayi RE15519p 0.002 0.0009 0.0009
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0025 0.0038 0.0424
Brugia malayi Trypsin family protein 0.0066 0.0277 0.0277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0249 0.0805
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0265 0.0265
Toxoplasma gondii PAN/Apple domain-containing protein 0.0034 0.0089 0.0133
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Brugia malayi sulfakinin receptor protein 0.002 0.0009 0.0009
Brugia malayi cathepsin L-like precursor 0.002 0.0005 0.0005
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0013 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0267 0.1472 1
Onchocerca volvulus 0.0025 0.0038 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0009 0.0009
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.037 0.0661
Toxoplasma gondii hypothetical protein 0.0114 0.0563 0.0983
Toxoplasma gondii PAN domain-containing protein 0.0316 0.1762 0.3131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus multilocularis cysteine protease 0.0025 0.0038 0.0068
Echinococcus multilocularis Furin 1 0.0053 0.0201 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0009 0.0009
Schistosoma mansoni amine GPCR 0.002 0.0009 0.0009
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0015 0.0027
Schistosoma mansoni hypothetical protein 0.0165 0.087 0.087
Schistosoma mansoni cathepsin D (A01 family) 0.0105 0.0508 0.0508
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0009 0.0017
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0009 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Echinococcus multilocularis 0.0053 0.0201 0.0358
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0114 0.0563 0.0983
Onchocerca volvulus 0.0036 0.0101 0.0173
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0015 0.0101
Loa Loa (eye worm) hypothetical protein 0.0034 0.0088 0.0088
Brugia malayi follicle stimulating hormone receptor 0.002 0.0009 0.0009
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0089 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0451 0.3065
Onchocerca volvulus 0.0053 0.0201 0.035
Onchocerca volvulus 0.002 0.0009 0.0008
Loa Loa (eye worm) prolyl oligopeptidase 0.0114 0.0563 0.0563
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Onchocerca volvulus 0.002 0.0009 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0101 0.069
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni multidrug resistance protein 0.0021 0.0015 0.0015
Loa Loa (eye worm) calpain D 0.0024 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0089
Mycobacterium leprae Probable lipase LipE 0.0036 0.0101 0.0071
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0024 0.0033 0.0059
Leishmania major cysteine peptidase A (CPA) 0.0025 0.0038 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0101
Brugia malayi Cathepsin L-like precursor 0.0025 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0009 0.0009
Trypanosoma cruzi kinesin, putative 0.0057 0.0225 0.0402
Brugia malayi Melatonin receptor type 1A 0.002 0.0009 0.0009
Echinococcus granulosus cathepsin b 0.0281 0.1556 0.2781
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0015 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0015 0.0101
Schistosoma mansoni smdr2 0.0021 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0066 0.0277 0.0277
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0009 0.0009
Echinococcus multilocularis calpain 0.0081 0.037 0.0661
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0038 0.0259
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0015 0.0101
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0009 0.0009
Toxoplasma gondii kringle domain-containing protein 0.0076 0.0338 0.058
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0101 0.158
Echinococcus multilocularis enteropeptidase 0.0066 0.0277 0.0496
Echinococcus multilocularis neuroendocrine convertase 2 0.0053 0.0201 0.0358
Toxoplasma gondii PAN domain-containing protein 0.0316 0.1762 0.3131
Plasmodium vivax SET domain protein, putative 0.0034 0.0088 0.133
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0101 0.0071
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0009 0.0017
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Leishmania major hypothetical protein, conserved 0.0076 0.0338 0.0605
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0009 0.0017
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0033 0.0224
Schistosoma mansoni amine GPCR 0.002 0.0009 0.0009
Schistosoma mansoni biogenic amine receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0089
Brugia malayi beta-lactamase family protein 0.0036 0.0101 0.0101
Leishmania major cathepsin L-like protease 0.0025 0.0038 0.0068
Trypanosoma brucei Calpain-like protein 1.2 0.0024 0.0033 0.0059
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0053 0.0201 0.0408
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0038
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0009 0.0017
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Loa Loa (eye worm) endoprotease bli-4 0.0053 0.0201 0.0201
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0114 0.0563 0.1007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0009 0.0017
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0101 0.0181
Echinococcus granulosus neuropeptide s receptor 0.002 0.0009 0.0017
Trichomonas vaginalis esterase, putative 0.0036 0.0101 0.069
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0009 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0025 0.0038 0.0424
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.037 0.0661
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Loa Loa (eye worm) hypothetical protein 0.0962 0.5595 0.5595
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0166 0.0166
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0015 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.011 0.017
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0009 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0101 0.069
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0114 0.0563 0.0563
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0066 0.0277 0.0496
Loa Loa (eye worm) subtilase 0.1705 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0009 0.0016
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0009 0.0017
Onchocerca volvulus 0.002 0.0009 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0009 0.0009
Onchocerca volvulus 0.002 0.0009 0.0008
Brugia malayi ecdysteroid receptor 0.002 0.0009 0.0009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0962 0.5595 0.5595
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0009 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0009 0.0017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.1556 0.1556
Loa Loa (eye worm) hypothetical protein 0.0053 0.0201 0.0201
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0009 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0541 0.3096 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0101 0.0181
Loa Loa (eye worm) calpain 0.0081 0.037 0.037
Brugia malayi prolyl oligopeptidase family protein 0.0114 0.0563 0.0563
Trypanosoma brucei calpain-like protein, putative 0.0081 0.037 0.0661
Brugia malayi celfurPC protein 0.0053 0.0201 0.0201
Trypanosoma brucei cysteine peptidase, putative 0.0024 0.0033 0.0059
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0009 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.005 0.009
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0249 0.0249
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0009 0.0009
Leishmania major cathepsin L-like protease 0.0025 0.0038 0.0068
Loa Loa (eye worm) hypothetical protein 0.0191 0.102 0.102
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0015 0.0027
Brugia malayi Trypsin family protein 0.0066 0.0277 0.0277
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0215 0.1164 0.1164
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0563 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0101 0.0101
Echinococcus granulosus neuropeptide receptor 0.002 0.0009 0.0017
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0009 0.0017
Trichomonas vaginalis hypothetical protein 0.0024 0.0033 0.0224
Brugia malayi Dopamine receptor protein 2 0.002 0.0009 0.0009
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0283 0.0505
Leishmania major calpain protease-like protein 0.0024 0.0033 0.0059
Trypanosoma brucei prolyl endopeptidase 0.0962 0.5595 1
Brugia malayi prolyl oligopeptidase family protein 0.0281 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0009 0.0009
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0114 0.0563 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.011 0.0745
Echinococcus multilocularis cysteine protease 0.0025 0.0038 0.0068
Schistosoma mansoni neuropeptide receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0009 0.0009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0009 0.0016
Schistosoma mansoni calpain-7 (C02 family) 0.0081 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus serotonin receptor 0.002 0.0009 0.0017
Echinococcus granulosus cathepsin b 0.0281 0.1556 0.2781
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0038 0.0038
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0009 0.0009
Brugia malayi calpain 7 0.0081 0.037 0.037
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.011 0.0196
Trichomonas vaginalis calpain, putative 0.0024 0.0033 0.0224
Trichomonas vaginalis abcb9, putative 0.0021 0.0015 0.0101
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0015 0.0101
Schistosoma mansoni hypothetical protein 0.0031 0.007 0.007
Echinococcus multilocularis calpain A 0.0228 0.1243 0.2222
Loa Loa (eye worm) fli-1 protein 0.0238 0.1302 0.1302
Onchocerca volvulus 0.0066 0.0277 0.0487
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.037 0.0661
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0009 0.0009
Onchocerca volvulus Cathepsin F homolog 0.0025 0.0038 0.0059
Brugia malayi proprotein convertase 2 0.0053 0.0201 0.0201
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0089 0.0089
Onchocerca volvulus 0.0034 0.0089 0.015
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0244 0.1333 0.1333
Toxoplasma gondii subtilisin SUB8 0.0053 0.0201 0.0333
Schistosoma mansoni nuclear hormone receptor 0.002 0.0009 0.0009
Leishmania major subtilisin-like serine peptidase 0.0053 0.0201 0.0358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0009 0.0009
Onchocerca volvulus 0.0034 0.0089 0.015
Loa Loa (eye worm) RNA binding protein 0.0063 0.0265 0.0265
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0033 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.007 0.0473
Onchocerca volvulus 0.0036 0.0101 0.0173
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0391 0.2209 0.3949
Entamoeba histolytica calpain large subunit domain III containing protein 0.0057 0.0225 0.3993
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Brugia malayi MH1 domain containing protein 0.0033 0.0081 0.0081
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0009 0.0009
Brugia malayi ORL1-like opioid receptor 0.002 0.0009 0.0009
Schistosoma mansoni biogenic amine receptor 0.002 0.0009 0.0009
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.011 0.0745
Onchocerca volvulus 0.002 0.0009 0.0008
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0009 0.0009
Onchocerca volvulus 0.002 0.0009 0.0008
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0089 0.0089
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0009 0.0017
Toxoplasma gondii subtilisin SUB2 0.0053 0.0201 0.0333
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0015 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Schistosoma mansoni inositol monophosphatase 0.0037 0.011 0.011
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0015 0.0263
Onchocerca volvulus 0.0034 0.0089 0.015
Onchocerca volvulus 0.002 0.0009 0.0008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0009 0.0009
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0033 0.0059
Brugia malayi calpain family protein 1 0.0215 0.1164 0.1164
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0033 0.0224
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0009 0.0017
Leishmania major cathepsin L-like protease 0.0073 0.032 0.0572
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0009 0.0009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus fmrfamide receptor 0.002 0.0009 0.0017
Brugia malayi Kringle domain containing protein 0.0076 0.0338 0.0338
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0088 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0009 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0005 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0009 0.0016
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0066 0.0277 0.0277
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0009 0.0009
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0015 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Echinococcus granulosus neuropeptide receptor 0.002 0.0009 0.0017
Schistosoma mansoni opsin-like receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni thyroid hormone receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0009 0.0017
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0228 0.1242 0.1242
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0015 0.0015
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.032 0.0572
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0033 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0228 0.1242 0.222
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0015 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.016 0.0286
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0638 0.3674 0.6567
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0281 0.1557 0.2783
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0201 0.1363
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0038 0.0059
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0009 0.0017
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0265 0.0265
Mycobacterium tuberculosis Probable peptidase 0.0391 0.2209 0.449
Onchocerca volvulus Cell death protein 3 homolog 0.007 0.0303 0.0533
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0249 0.0805
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0277 0.0496
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0269 0.1485 0.2655
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0067 0.0286 0.0286
Toxoplasma gondii subtilisin SUB9 0.0053 0.0201 0.0333
Echinococcus granulosus g-protein coupled receptor 0.002 0.0009 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0541 0.3096 0.6292
Trypanosoma cruzi subtilisin peptidase 0.0053 0.0201 0.0358
Giardia lamblia Cathepsin B precursor 0.0095 0.0451 0.8006
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0101 0.0328
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0015 0.0101
Leishmania major cathepsin L-like protease 0.0073 0.032 0.0572
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0081 0.037 0.0661
Loa Loa (eye worm) hypothetical protein 0.0066 0.0277 0.0277
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0228 0.1242 0.1242
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0038 0.0676
Echinococcus granulosus transmembrane protease serine 3 0.0066 0.0277 0.0496
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0009 0.0009
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0196
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0033 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Onchocerca volvulus 0.002 0.0009 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0009 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0101 0.0181
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.011 0.1946
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0009 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0009 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0009 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0265 0.0265
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0009 0.0017
Echinococcus granulosus allatostatin A receptor 0.002 0.0009 0.0017
Schistosoma mansoni amine GPCR 0.002 0.0009 0.0009
Brugia malayi Pre-SET motif family protein 0.0235 0.128 0.128
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0009 0.0009
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0015 0.0263
Brugia malayi RNA binding protein 0.0063 0.0265 0.0265
Brugia malayi Ets-domain containing protein 0.0079 0.0354 0.0354
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0053 0.0201 0.0408
Loa Loa (eye worm) hypothetical protein 0.007 0.0303 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Brugia malayi MH1 domain containing protein 0.0033 0.0081 0.0081
Onchocerca volvulus 0.0269 0.1485 0.2648
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0009 0.0009
Echinococcus granulosus tissue type plasminogen activator 0.0076 0.0338 0.0605
Schistosoma mansoni P2X receptor subunit 0.0067 0.0283 0.0283
Onchocerca volvulus 0.0034 0.0089 0.015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0249 0.0445
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.128 0.128
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0009 0.0017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0038 0.0068
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0009 0.0009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0015 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0391 0.2209 0.7136
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Echinococcus granulosus Smad4 0.0033 0.0081 0.0145
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0095 0.0451 0.0806
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.037 0.0661
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.1705 1 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0081 0.0145
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0101 0.0181
Trichomonas vaginalis abcb9, putative 0.0021 0.0015 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.011 0.0354
Toxoplasma gondii subtilisin SUB5 0.0053 0.0201 0.0333
Leishmania major cathepsin L-like protease 0.0073 0.032 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Schistosoma mansoni furin-1 (S08 family) 0.0053 0.0201 0.0201
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0009 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0009 0.0009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.011 0.0745
Trypanosoma cruzi kinesin, putative 0.0057 0.0225 0.0402
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0053 0.0201 0.0648
Entamoeba histolytica prolyl oligopeptidase family protein 0.0114 0.0563 1
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0638 0.3674 0.6567
Schistosoma mansoni gabp alpha 0.0079 0.0354 0.0354
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0033 0.0059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0009 0.0009
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0015 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0033 0.0224
Loa Loa (eye worm) hypothetical protein 0.0114 0.0563 0.0563
Schistosoma mansoni inhibitor of apoptosis protein 0.0269 0.1485 0.1485
Loa Loa (eye worm) calpain 5 0.0057 0.0225 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0009 0.0009
Toxoplasma gondii ABC1 family protein 0.0036 0.0101 0.0155
Echinococcus multilocularis hypothetical protein 0.0081 0.037 0.0661
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0009 0.0008
Brugia malayi hypothetical protein 0.0066 0.0277 0.0277
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.005 0.0064
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.011 0.0196
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0101 0.069
Brugia malayi Ets-domain containing protein 0.0079 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0005 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0066 0.0277 0.0277
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0009 0.0017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0101 0.0206
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0038 0.0068
Onchocerca volvulus 0.002 0.0009 0.0008
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0015 0.0027
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0101 0.0328
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0066 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.037 0.0661
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0066 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus acylamino acid releasing enzyme 0.0114 0.0563 0.1007
Loa Loa (eye worm) cysteine protease 0.0025 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Plasmodium falciparum prefoldin subunit 6, putative 0.0031 0.007 0.0999
Trichomonas vaginalis taga, putative 0.0021 0.0015 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Echinococcus granulosus g protein coupled receptor 0.002 0.0009 0.0017
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0009 0.0017
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Brugia malayi Trypsin-like protease protein 5 0.0066 0.0277 0.0277
Trypanosoma cruzi oligopeptidase b 0.0391 0.2209 0.3949
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus prolyl endopeptidase 0.0962 0.5595 1
Echinococcus multilocularis sex peptide receptor 0.002 0.0009 0.0017
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0089 0.0089
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0101 0.0206
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0066 0.0277 0.0277
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0081 0.0081
Trypanosoma brucei antigen, putative 0.0081 0.037 0.0661
Echinococcus granulosus Furin 1 0.0053 0.0201 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Schistosoma mansoni site-1 peptidase (S08 family) 0.0053 0.0201 0.0201
Onchocerca volvulus 0.002 0.0009 0.0008
Onchocerca volvulus 0.0134 0.0683 0.1213
Brugia malayi Cathepsin L-like precursor 0.002 0.0005 0.0005
Brugia malayi calpain D 0.0024 0.0033 0.0033
Brugia malayi multidrug resistance protein 3 0.0021 0.0015 0.0015
Echinococcus multilocularis transmembrane protease serine 3 0.0066 0.0277 0.0496
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0009 0.0009
Brugia malayi G-protein coupled receptor 0.002 0.0009 0.0009
Schistosoma mansoni adenoreceptor 0.002 0.0009 0.0009
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0053 0.0201 0.0358
Echinococcus granulosus membrane bound transcription factor site 1 0.0053 0.0201 0.0358
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.016 0.0286
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0095 0.0451 0.0806
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0088 0.0088
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0281 0.1557 0.2776
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0009 0.0017
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0114 0.0563 0.3828
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0089 0.0133
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0089 0.0133
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0161 0.0841 0.1502
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1251 0.2542
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0009 0.0016
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0009 0.0017
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0015 0.0027
Brugia malayi Fli-1 protein 0.0238 0.1302 0.1302
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0283 0.0505
Loa Loa (eye worm) prolyl oligopeptidase 0.0281 0.1557 0.1557
Onchocerca volvulus Deterin homolog 0.0269 0.1485 0.2648
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0249 0.0506
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0015 0.0027
Toxoplasma gondii subtilisin SUB6 0.0053 0.0201 0.0333
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Echinococcus multilocularis cathepsin L cysteine protease 0.0025 0.0038 0.0068
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0015 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Toxoplasma gondii cathepsin B 0.0095 0.0451 0.0782
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0025 0.0038 0.0259
Giardia lamblia Alanyl dipeptidyl peptidase 0.0114 0.0563 1
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus orexin receptor type 2 0.002 0.0009 0.0017
Echinococcus multilocularis g protein coupled receptor 0.002 0.0009 0.0017
Echinococcus granulosus prefoldin subunit 6 0.0031 0.007 0.0124
Brugia malayi Cathepsin L-like precursor 0.0025 0.0038 0.0038
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0086 0.0176
Leishmania major hypothetical protein, conserved 0.0036 0.0101 0.0181
Mycobacterium ulcerans lipase LipD 0.0036 0.0101 0.0328
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0009 0.0009
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0161 0.0841 0.0841
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0009 0.0017
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0015 0.0101
Loa Loa (eye worm) hypothetical protein 0.0269 0.1485 0.1485
Toxoplasma gondii microneme protein MIC17A 0.0034 0.0089 0.0133
Leishmania major kinesin, putative 0.0057 0.0225 0.0402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.1556 0.1556
Plasmodium falciparum peptidase, putative 0.0114 0.0563 1
Toxoplasma gondii cathepsin CPL 0.0025 0.0038 0.0042
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0053 0.0201 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0563 0.1007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0009 0.0009
Brugia malayi calpain 5 0.0059 0.0237 0.0237
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0076 0.0338 0.5897
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0038 0.0038
Brugia malayi hypothetical protein 0.0027 0.005 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0009 0.0016
Onchocerca volvulus 0.0066 0.0277 0.0487
Echinococcus granulosus cathepsin l1 0.002 0.0005 0.0009
Brugia malayi MH2 domain containing protein 0.0033 0.0081 0.0081
Entamoeba histolytica calpain family cysteine protease, putative 0.0024 0.0033 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0033 0.0224
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0244 0.1333 0.1333
Echinococcus granulosus Mastin 0.0066 0.0277 0.0496
Loa Loa (eye worm) hypothetical protein 0.0076 0.0338 0.0338
Mycobacterium ulcerans hypothetical protein 0.0036 0.0101 0.0328
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0269 0.1485 0.1485
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0015 0.0027
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0283 0.0505
Echinococcus multilocularis geminin 0.0165 0.087 0.1554
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0053 0.0201 0.0358
Brugia malayi prolyl oligopeptidase family protein 0.0962 0.5595 0.5595
Trypanosoma cruzi conserved protein 0.0024 0.0033 0.0059
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.011 0.5
Toxoplasma gondii microneme protein MIC4 0.0034 0.0089 0.0133
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.037 0.0661
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0161 0.0841 0.1502
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0281 0.1557 0.1557
Echinococcus multilocularis orexin receptor type 2 0.002 0.0009 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0009 0.0009
Loa Loa (eye worm) fibroinase 0.0025 0.0038 0.0038
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0015 0.0101
Schistosoma mansoni calpain-7 (C02 family) 0.0081 0.037 0.037
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0053 0.0201 0.0201
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.037 0.0661
Toxoplasma gondii microneme protein MIC17B 0.0034 0.0089 0.0133
Echinococcus multilocularis Mastin 0.0066 0.0277 0.0496
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus calpain 7 C02 family 0.0081 0.037 0.0661
Onchocerca volvulus 0.007 0.0303 0.0533
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Echinococcus granulosus smad 0.0033 0.0081 0.0145
Onchocerca volvulus 0.0034 0.0089 0.015
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0015 0.0101
Schistosoma mansoni Mername-AA248 (C02 family) 0.0083 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) transcription factor SMAD2 0.0478 0.2723 0.2723
Brugia malayi prolyl oligopeptidase family protein 0.0161 0.0841 0.0841
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0338 0.0605
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0015 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0201 0.1363
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0081 0.0081
Brugia malayi Dopamine receptor 0.002 0.0009 0.0009
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0114 0.0563 0.0563
Schistosoma mansoni hypothetical protein 0.007 0.0303 0.0303
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0015 0.003
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0101 0.0206
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0009 0.0016
Schistosoma mansoni hypothetical protein 0.0024 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0563 0.1007
Trypanosoma brucei calpain, putative 0.0024 0.0033 0.0059
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0009 0.0009
Onchocerca volvulus 0.0025 0.0038 0.0059
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0089 0.0133
Onchocerca volvulus 0.0076 0.0338 0.0596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0015 0.0101
Echinococcus multilocularis caspase 2 0.007 0.0303 0.0541
Echinococcus multilocularis serotonin receptor 0.002 0.0009 0.0017
Onchocerca volvulus 0.0025 0.0038 0.0059
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0255 0.1401 0.2504
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0009 0.0016
Schistosoma mansoni amine GPCR 0.002 0.0009 0.0009
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0053 0.0201 0.0538
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0249 0.0805
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus granulosus apoptotic protease activating factor 1 0.007 0.0303 0.0541
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni P2X receptor subunit 0.0067 0.0283 0.0283
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0101 0.0101
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis inhibitor of apoptosis protein 0.0269 0.1485 0.2655
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0066 0.0277 0.0277
Brugia malayi Serotonin receptor 0.002 0.0009 0.0009
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0161 0.0841 0.1502
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0009 0.0017
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0161 0.0841 0.1502
Echinococcus multilocularis neuropeptide receptor 0.002 0.0009 0.0017
Schistosoma mansoni smad 0.0033 0.0081 0.0081
Onchocerca volvulus 0.0034 0.0089 0.015
Brugia malayi Cathepsin L-like precursor 0.0025 0.0038 0.0038
Entamoeba histolytica hypothetical protein, conserved 0.0114 0.0563 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0088 0.0131
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0009 0.0009
Echinococcus granulosus calpain A 0.0228 0.1243 0.2222
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0283 0.0505
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.037 0.0661
Echinococcus multilocularis prolyl endopeptidase 0.0962 0.5595 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0009 0.0007
Plasmodium falciparum subtilisin-like protease 3 0.0053 0.0201 0.3386
Onchocerca volvulus 0.0066 0.0277 0.0487
Brugia malayi Protein kinase domain containing protein 0.0076 0.0338 0.0338
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0196
Echinococcus granulosus calpain 5 0.0083 0.0382 0.0683
Plasmodium vivax vivapain-2 0.0025 0.0038 0.0424
Plasmodium falciparum calpain 0.0024 0.0033 0.0331
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0228 0.1242 0.222
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0009 0.0017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0009 0.0009
Leishmania major cathepsin L-like protease 0.0025 0.0038 0.0068
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Onchocerca volvulus 0.0034 0.0089 0.015
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0015 0.0263
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Entamoeba histolytica cysteine protease, putative 0.0025 0.0038 0.0676
Loa Loa (eye worm) inositol-1 0.0037 0.011 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0009 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0009 0.0009
Schistosoma mansoni smad1 5 8 and 0.0033 0.0081 0.0081
Echinococcus multilocularis cathepsin b 0.0281 0.1556 0.2781
Loa Loa (eye worm) hypothetical protein 0.0134 0.0683 0.0683
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Brugia malayi KE2 family protein 0.0031 0.007 0.007
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0265 0.0265
Mycobacterium ulcerans hypothetical protein 0.0066 0.0277 0.0896
Echinococcus multilocularis smad 0.0033 0.0081 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.032 0.0572
Onchocerca volvulus 0.002 0.0009 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0009 0.0017
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0024 0.0033 0.0033
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0033 0.0059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Plasmodium vivax subtilisin-like protease 2, putative 0.0053 0.0201 0.3386
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0201 0.1363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Onchocerca volvulus 0.0025 0.0038 0.0059
Schistosoma mansoni opsin-like receptor 0.002 0.0009 0.0009
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0053 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.007 0.0303 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0201 0.1363
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0009 0.0017
Loa Loa (eye worm) beta-lactamase 0.0036 0.0101 0.0101
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0277 0.0277
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0101 0.0181
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Echinococcus granulosus enteropeptidase 0.0066 0.0277 0.0496
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0249 0.042
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0354 0.0633
Giardia lamblia Hypothetical protein 0.0031 0.007 0.1236
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0009 0.0017
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Plasmodium vivax subtilisin-like serine protease, putative 0.0053 0.0201 0.3386
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0009 0.0009
Brugia malayi neuropeptide F receptor 0.002 0.0009 0.0009
Brugia malayi beta-lactamase family protein 0.0036 0.0101 0.0101
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.037 0.0661
Onchocerca volvulus 0.002 0.0009 0.0008
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0009 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0009 0.0017
Brugia malayi Inositol-1 0.0037 0.011 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0015 0.0101
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0033 0.0224
Onchocerca volvulus 0.002 0.0009 0.0008
Trypanosoma cruzi prefoldin subunit, putative 0.0031 0.007 0.0124
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Echinococcus multilocularis apoptotic protease activating factor 1 0.007 0.0303 0.0541
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0033 0.0059
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus cathepsin L cysteine proteinase 0.0025 0.0038 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0101 0.069
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0009 0.0009
Schistosoma mansoni multidrug resistance protein 0.0021 0.0015 0.0015
Schistosoma mansoni smad1 5 8 and 0.0033 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Toxoplasma gondii hypothetical protein 0.0034 0.0089 0.0133
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0009 0.0017
Schistosoma mansoni multidrug resistance protein 0.0021 0.0015 0.0015
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0009 0.0017
Toxoplasma gondii microneme protein, putative 0.0034 0.0089 0.0133
Toxoplasma gondii subtilisin SUB10 0.0053 0.0201 0.0333
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Schistosoma mansoni caspase-7 (C14 family) 0.007 0.0303 0.0303
Toxoplasma gondii hypothetical protein 0.0034 0.0089 0.0133
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0066 0.0277 0.0496
Loa Loa (eye worm) TK/ROR protein kinase 0.0076 0.0338 0.0338
Toxoplasma gondii prefoldin subunit 6, putative 0.0031 0.007 0.0098
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0009 0.0009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.1556 0.1556
Echinococcus granulosus caspase 2 0.007 0.0303 0.0541
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Trypanosoma brucei Calpain-like protein CALP1.3 0.0024 0.0033 0.0059
Plasmodium vivax calpain, putative 0.0081 0.037 0.6469
Brugia malayi Dopamine receptor protein 1 0.002 0.0009 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0015 0.0263
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0009 0.0017
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0053 0.0201 0.0201
Echinococcus multilocularis acylamino acid releasing enzyme 0.0114 0.0563 0.1007
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0101 0.0206
Schistosoma mansoni biogenic amine receptor 0.002 0.0009 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0009 0.0009
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0013 0.0024
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0033 0.0059
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Giardia lamblia Cathepsin B precursor 0.0095 0.0451 0.8006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0101 0.0206
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0009 0.0009
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0161 0.0841 0.148
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0015 0.0263
Brugia malayi Cathepsin L-like cysteine proteinase 0.002 0.0005 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0009 0.0016
Toxoplasma gondii subtilisin SUB12 0.0087 0.0401 0.0693
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0081 0.037 0.0661
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0101 0.0206
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0269 0.1485 0.1485
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0089
Mycobacterium tuberculosis Conserved protein 0.0036 0.0101 0.0206
Trypanosoma brucei prefoldin subunit, putative 0.0031 0.007 0.0124
Echinococcus multilocularis somatostatin receptor 0.002 0.0009 0.0017
Trypanosoma cruzi prolyl endopeptidase 0.0962 0.5595 1
Loa Loa (eye worm) Smad1 0.0033 0.0081 0.0081
Echinococcus multilocularis allatostatin A receptor 0.002 0.0009 0.0017
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0015 0.0101
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Mycobacterium leprae Possible secreted protease 0.0053 0.0201 0.0538
Brugia malayi Cathepsin L-like precursor 0.0025 0.0038 0.0038
Echinococcus granulosus cathepsin l1 0.0025 0.0038 0.0068
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0009 0.0009
Brugia malayi G-protein coupled receptor 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Brugia malayi prolyl oligopeptidase family protein 0.0114 0.0563 0.0563
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0053 0.0201 0.0648
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0161 0.0841 0.1502
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Loa Loa (eye worm) proprotein convertase 2 0.0053 0.0201 0.0201
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0277 0.0277
Schistosoma mansoni opsin-like receptor 0.002 0.0009 0.0009
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0033 0.0059
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0101
Plasmodium vivax prefoldin subunit 6, putative 0.0031 0.007 0.0999
Brugia malayi GnHR receptor homolog 0.002 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0015 0.0101
Echinococcus multilocularis Smad4 0.0033 0.0081 0.0145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0009 0.0009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0033 0.0224
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0009 0.0009
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0005 0.0033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0277 0.0277
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0009 0.0017
Leishmania major calpain family cysteine protease-like protein 0.0024 0.0033 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0009 0.0009
Brugia malayi cathepsin B-like cysteine proteinase 0.0281 0.1556 0.1556
Echinococcus granulosus g protein coupled receptor 0.002 0.0009 0.0017
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0201 0.1363
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0067 0.0287 0.0513
Brugia malayi AKH receptor 0.002 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0265 0.0265
Echinococcus multilocularis calpain 5 0.0083 0.0382 0.0683
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0101
Trypanosoma brucei Calpain-like protein 2 0.0024 0.0033 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0038 0.0676
Brugia malayi endoprotease bli-4 precursor 0.0053 0.0201 0.0201
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0015 0.0101
Onchocerca volvulus 0.0034 0.0089 0.015
Brugia malayi Smad1 0.0033 0.0081 0.0081
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0451 0.0451
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0015 0.0101
Echinococcus multilocularis fmrfamide receptor 0.002 0.0009 0.0017
Brugia malayi ABC transporter family protein 0.0021 0.0015 0.0015
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0088 0.0157
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0038 0.0038
Plasmodium vivax vivapain-2 0.0025 0.0038 0.0424
Trypanosoma brucei oligopeptidase b 0.0391 0.2209 0.3949
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0101 0.0206
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0053 0.0201 0.0358
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0015 0.0101
Trypanosoma brucei kinesin, putative 0.0057 0.0225 0.0402
Schistosoma mansoni cathepsin D (A01 family) 0.0105 0.0508 0.0508
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0848 0.492 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0009 0.0009
Echinococcus granulosus FTZ F1 alpha 0.002 0.0009 0.0016
Brugia malayi Cathepsin L-like precursor 0.0025 0.0038 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0009 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0277 0.0277
Mycobacterium tuberculosis Conserved protein 0.0036 0.0101 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0088 0.0088
Brugia malayi hypothetical protein 0.0047 0.0166 0.0166
Schistosoma mansoni neuropeptide receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0244 0.1333 0.1333
Trypanosoma brucei subtilisin peptidase 0.0053 0.0201 0.0358
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Onchocerca volvulus 0.0025 0.0038 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Brugia malayi neuropeptide F receptor 0.002 0.0009 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.037 0.0661
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0255 0.1401 0.2504
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Onchocerca volvulus 0.0025 0.0038 0.0059
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0009 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0009 0.0017
Schistosoma mansoni P2X receptor subunit 0.0067 0.0283 0.0283
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0277 0.0277
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0015 0.0015
Toxoplasma gondii subtilisin SUB1 0.0053 0.0201 0.0333
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Onchocerca volvulus 0.002 0.0009 0.0008
Leishmania major oligopeptidase b 0.0391 0.2209 0.3949
Trypanosoma cruzi prefoldin subunit, putative 0.0031 0.007 0.0124
Loa Loa (eye worm) ctsf protein 0.0025 0.0038 0.0038
Loa Loa (eye worm) calpain family protein 1 0.0215 0.1164 0.1164
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0066 0.0277 0.0496
Plasmodium falciparum cysteine repeat modular protein 1 0.0076 0.0338 0.5897
Plasmodium falciparum subtilisin-like protease 2 0.0053 0.0201 0.3386
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0281 0.1557 0.2783
Onchocerca volvulus 0.0178 0.0944 0.168
Plasmodium falciparum plasmepsin X 0.0091 0.0429 0.7557
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0015 0.5
Echinococcus multilocularis serotonin receptor 0.002 0.0009 0.0017
Onchocerca volvulus 0.0034 0.0089 0.015
Schistosoma mansoni calpain C (C02 family) 0.0081 0.037 0.037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0009 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0009 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0277 0.0277
Echinococcus multilocularis glycoprotein Antigen 5 0.0066 0.0277 0.0496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0025 0.0038 0.0259
Brugia malayi hypothetical protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Mycobacterium tuberculosis Conserved protein 0.0036 0.0101 0.0206
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0009 0.0017
Brugia malayi Trypsin family protein 0.0244 0.1333 0.1333
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0249 0.0249
Brugia malayi calpain 5 0.0024 0.0033 0.0033
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0009 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0101 0.069
Mycobacterium ulcerans beta-lactamase 0.0036 0.0101 0.0328
Echinococcus granulosus furin 0.0053 0.0201 0.0358
Brugia malayi Serotonin receptor 0.002 0.0009 0.0009
Onchocerca volvulus 0.0025 0.0038 0.0059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.008 0.0144
Brugia malayi hypothetical protein 0.007 0.0303 0.0303
Echinococcus multilocularis membrane bound transcription factor site 1 0.0053 0.0201 0.0358
Brugia malayi TAR-binding protein 0.0063 0.0265 0.0265
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0269 0.1485 0.1485
Loa Loa (eye worm) calpain family protein 1 0.0158 0.0828 0.0828
Leishmania major hypothetical protein, conserved 0.0024 0.0033 0.0059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.016 0.016
Brugia malayi putative neuropeptide receptor 0.002 0.0009 0.0009
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0015 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Brugia malayi Cell death protein 3 precursor 0.007 0.0303 0.0303
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0089 0.0089
Brugia malayi PAN domain containing protein 0.0034 0.0089 0.0089
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0053 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0114 0.0563 0.0563
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0269 0.1485 0.1485
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0024 0.0033 0.0059
Schistosoma mansoni smad1 5 8 and 0.0033 0.0081 0.0081
Echinococcus granulosus sex peptide receptor 0.002 0.0009 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.016 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.016 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.032 0.0572
Onchocerca volvulus 0.002 0.0009 0.0008
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0114 0.0563 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0009 0.0016
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0391 0.2209 0.3949
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0391 0.2209 0.449
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0081 0.0145
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0009 0.0016
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0283 0.0505
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0009 0.0017
Echinococcus multilocularis cathepsin b 0.0281 0.1556 0.2781
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0354 0.0354
Trypanosoma brucei calpain-like protein, putative 0.0081 0.037 0.0661
Brugia malayi Pre-SET motif family protein 0.0034 0.0088 0.0088
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0283 0.0505
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0391 0.2209 0.3949
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0009 0.0017
Loa Loa (eye worm) trypsin family protein 0.0066 0.0277 0.0277
Plasmodium vivax aspartyl protease, putative 0.0091 0.0429 0.7557
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0025 0.0038 0.0068
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0354 0.0633
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0038 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0009 0.0009
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0081 0.0145
Echinococcus granulosus neuroendocrine convertase 2 0.0053 0.0201 0.0358
Loa Loa (eye worm) hypothetical protein 0.0281 0.1556 0.1556
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0196
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0009 0.0017
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0081 0.0145
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0015 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0053 0.0201 0.1363
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.005 0.009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0009 0.0009
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0015 0.0027
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0391 0.2209 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0009 0.0009
Leishmania major cathepsin L-like protease 0.0025 0.0038 0.0068
Schistosoma mansoni hypothetical protein 0.0066 0.0277 0.0277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.016 0.0286
Schistosoma mansoni histamine h1 receptor 0.002 0.0009 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0244 0.1333 0.1333
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0255 0.1401 0.1401
Echinococcus multilocularis calpain family protein 1, d 0.0158 0.0828 0.148
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.005 0.0648
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0033 0.0059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.037 0.0661
Schistosoma mansoni inositol monophosphatase 0.0037 0.011 0.011
Brugia malayi MH2 domain containing protein 0.0478 0.2723 0.2723
Schistosoma mansoni coup transcription factor 0.002 0.0009 0.0009
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0009 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0009 0.0017

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8 Displacement of radioligand [3H]-5-HT binding to 5-hydroxytryptamine 1D receptor in pig caudate membrane ChEMBL. 8496922
Log IC50 (binding) = 8 Displacement of radioligand [3H]-5-HT binding to 5-hydroxytryptamine 1D receptor in pig caudate membrane ChEMBL. 8496922
logD (ADMET) = 1.22 Partition coefficient (logD7.4) ChEMBL. 8496922

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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