Detailed information for compound 574373

Basic information

Technical information
  • TDR Targets ID: 574373
  • Name: N-[2-[[2-(1,2-dihydroxyethyl)-4,5-dihydroxy-6 -(7H-purin-6-ylamino)tetrahydropyran-3-yl]ami no]-2-oxo-ethyl]-14-methyl-pentadecanamide
  • MW: 621.769 | Formula: C30H51N7O7
  • H donors: 8 H acceptors: 9 LogP: 3.77 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 3
  • SMILES: OCC(C1OC(Nc2[nH]cnc3c2ncn3)C(C(C1NC(=O)CNC(=O)CCCCCCCCCCCCC(C)C)O)O)O
  • InChi: 1S/C30H51N7O7/c1-19(2)13-11-9-7-5-3-4-6-8-10-12-14-21(40)31-15-22(41)36-23-25(42)26(43)30(44-27(23)20(39)16-38)37-29-24-28(33-17-32-24)34-18-35-29/h17-20,23,25-27,30,38-39,42-43H,3-16H2,1-2H3,(H,31,40)(H,36,41)(H2,32,33,34,35,37)
  • InChiKey: YBZRLMLGUBIIDN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[[2-(1,2-dihydroxyethyl)-4,5-dihydroxy-6-(7H-purin-6-ylamino)-3-tetrahydropyranyl]amino]-2-oxoethyl]-14-methylpentadecanamide
  • N-[2-[[2-(1,2-dihydroxyethyl)-4,5-dihydroxy-6-(7H-purin-6-ylamino)oxan-3-yl]amino]-2-oxo-ethyl]-14-methyl-pentadecanamide
  • N-[2-[[2-(1,2-dihydroxyethyl)-4,5-dihydroxy-6-(7H-purin-6-ylamino)tetrahydropyran-3-yl]amino]-2-keto-ethyl]-14-methyl-pentadecanamide
  • N-[2-[[2-(1,2-dihydroxyethyl)-4,5-dihydroxy-6-(7H-purin-6-ylamino)oxan-3-yl]amino]-2-oxoethyl]-14-methylpentadecanamide
  • septacidin
  • 62362-59-8
  • 87099-85-2
  • 4-Deoxy-4-((((14-methylpentadecanoyl)amino)acetyl)amino)-N-(9H-purin-6-yl)heptopyranosylamine
  • AIDS-125209
  • C15751
  • Crystalline Antibiotic (B-17325)
  • L-Glycero-.beta.-L-gluco-Heptopyranosylamine, {4-deoxy-4-[[[(14-methyl-1-oxopentadecyl)amino]acetyl]amino]-N-1H-p} urin-6-yl-
  • NSC65104
  • Squibb antibiotic 1325
  • B 17325K008
  • L-glycero-.beta.-L-gluco-Heptopyranosylamine, 4-deoxy-4-[[[(14-methyl-1-oxopentadecyl)amino]acetyl]amino]-N-1H-purin-6-yl-
  • NCI60_017861
  • L-glycero-beta-L-manno-Heptopyranosylamine, 4-deoxy-4-((((14-methyl-1-oxopentadecyl)amino)acetyl)amino)-N-1H-purin-6-yl-
  • Spicamycin
  • AIDS125209
  • Crystalline Antibiotic

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0017 0.0085
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0013 0.0001 0.0033
Echinococcus granulosus glutamate receptor 2 0.0021 0.0017 0.0017
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0044 0.1039
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0001 0.0001
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0017 0.0017
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0013 0.0002 0.0009
Echinococcus granulosus expressed conserved protein 0.0296 0.0572 0.0572
Trypanosoma brucei heat shock protein, putative 0.0064 0.0104 0.2454
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0056 0.0088 0.0189
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0019 0.0019
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.0002 0.0003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0162 0.0303 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0305 0.059 0.059
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0183 0.1061
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0197 0.0373 0.0372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0073 0.1713
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0099
Trypanosoma brucei Heat shock protein 83, putative 0.0064 0.0104 0.2454
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0001 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0098 0.2312
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0016 0.0366
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0002 0.0009
Schistosoma mansoni Smad4 0.0033 0.0042 0.0042
Schistosoma mansoni lamin 0.0054 0.0085 0.0084
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0028 0.0028
Brugia malayi MH2 domain containing protein 0.0483 0.0949 0.4936
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.0189 0.4454
Schistosoma mansoni coup transcription factor 0.0022 0.0019 0.0019
Echinococcus granulosus glutamate receptor 2 0.003 0.0036 0.0036
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0002 0.0034
Onchocerca volvulus 0.0019 0.0014 0.0304
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0001 0.0001
Trypanosoma cruzi target of rapamycin kinase 3 0.0055 0.0087 0.2049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0064 0.0369
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Echinococcus multilocularis tar DNA binding protein 0.0211 0.04 0.04
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0087 0.0503
Echinococcus multilocularis muscleblind protein 0.0301 0.0583 0.0582
Brugia malayi hypothetical protein 0.0019 0.0014 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0028 0.0145
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0078 0.0451
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0162 0.0303 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0106 0.019 0.041
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0001 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0102 0.0101
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0044 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0012 0 0.0008
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0162 0.0303 0.0302
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0031 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.0139 0.0256 0.6047
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.0002 0.0003
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0003 0.0002
Toxoplasma gondii heat shock protein 90, putative 0.0064 0.0104 0.2454
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0001 0.0025
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0015 0.0015
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0042 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0003 0.0071
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0019 0.0019
Brugia malayi Pre-SET motif family protein 0.0208 0.0396 0.2057
Echinococcus granulosus intermediate filament protein 0.0054 0.0085 0.0084
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0048 0.0073 0.1713
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0063 0.0365
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Trichomonas vaginalis ferritin, putative 0.0018 0.0012 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0069 0.0396
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0044 0.1455
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0162 0.0303 0.7146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0009
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0005 0.0025
Schistosoma mansoni hypothetical protein 0.124 0.2476 0.2476
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0051 0.1209
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0064 0.0105 0.0105
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0019 0.0099
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.0002 0.0048
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0013 0.0001 0.0001
Loa Loa (eye worm) G protein alpha subunit 3 0.0013 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0048 0.0073 0.1713
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0001 0.0025
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0001 0.0025
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0 0.0008
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0013 0.0002 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.023 0.1195
Schistosoma mansoni heat shock protein 0.0064 0.0104 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0105 0.0611
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.0002 0.0013
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0016 0.0034
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0315
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0096 0.0095
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0203
Schistosoma mansoni smad1 5 8 and 0.0033 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0019 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0366
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0098 0.0569
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0013 0.0002 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0013 0.0002 0.0009
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0135 0.0248 0.1289
Trichomonas vaginalis D-aminoacylase, putative 0.0222 0.0424 0.2459
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0006 0.003
Echinococcus granulosus Niemann Pick C1 protein 0.045 0.0883 0.0883
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0019 0.0099
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0121 0.07
Trichomonas vaginalis mercuric reductase, putative 0.0048 0.0073 0.0421
Loa Loa (eye worm) hypothetical protein 0.0159 0.0296 0.1538
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0056 0.029
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0001 0.0025
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0033 0.0043 0.0042
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0044 0.1046
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0002 0.0001
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0031 0.101
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0064 0.0105 0.2484
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0012 0.0025
Loa Loa (eye worm) glutamate receptor 1 0.0025 0.0026 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0019 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Brugia malayi MAP kinase sur-1 0.0059 0.0096 0.0495
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0045 0.0234
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.0002 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0019 0.0019
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0096 0.2249
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Onchocerca volvulus 0.0013 0.0002 0.0036
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0014 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0044 0.0256
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0112 0.0579
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0002 0.0002
Brugia malayi chromobox protein homolog 3 0.004 0.0057 0.0295
Brugia malayi Pre-SET motif family protein 0.003 0.0037 0.019
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0096 0.2249
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0183 0.1061
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0104 0.2454
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0139 0.0256 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0064 0.0369
Brugia malayi protein C24B5.3 0.0019 0.0014 0.0071
Echinococcus multilocularis glutamate synthase 0.0013 0.0001 0.0001
Schistosoma mansoni disulfide oxidoreductase 0.0013 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0013 0.0001 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0013 0.0072
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.0183 0.0183
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0001 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0082 0.0476
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0096 0.521
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0057 0.0329
Treponema pallidum thioredoxin reductase (trxB) 0.0013 0.0001 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0096 0.0553
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0189 0.4454
Echinococcus multilocularis sterol regulatory element binding protein 0.0135 0.0248 0.0248
Brugia malayi Hsp90 protein 0.0026 0.0028 0.0145
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0019 0.0099
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0019 0.0019
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0002 0.0034
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0013 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0039 0.0927
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0019 0.0019
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0064 0.0105 0.1723
Echinococcus multilocularis glutamate receptor 2 0.0021 0.0017 0.0017
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0017 0.0017
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0112 0.0579
Trypanosoma cruzi hypothetical protein, conserved 0.0222 0.0424 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0366
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0102 0.0218
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0085 0.0439
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.0002 0.0003
Echinococcus granulosus peptidase Clp S14 family 0.0106 0.019 0.019
Echinococcus multilocularis expressed protein 0.0405 0.0791 0.0791
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.0405 0.2107
Onchocerca volvulus 0.0019 0.0014 0.0303
Schistosoma mansoni heat shock protein 0.0026 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0082 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0015 0.0085
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0002 0.0034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0222 0.0424 0.0921
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.023 0.1195
Mycobacterium tuberculosis Probable hydrolase 0.0222 0.0424 0.0921
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0063 0.1387
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Trichomonas vaginalis esterase, putative 0.0222 0.0424 0.2459
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0024 0.0024 0.0051
Onchocerca volvulus Protein patched homolog 0.0019 0.0014 0.0303
Echinococcus granulosus Smad4 0.0033 0.0042 0.0042
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0001 0.0006
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0013 0.0001 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0105 0.0611
Echinococcus granulosus solute carrier family 12 0.0049 0.0075 0.0075
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0084 0.0083
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0019 0.0019
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0026 0.0136
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0048 0.0073 0.172
Echinococcus multilocularis endoplasmin 0.0051 0.0078 0.0078
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0055 0.0087 0.2049
Echinococcus multilocularis protein patched 0.0135 0.0248 0.0248
Trichomonas vaginalis D-aminoacylase, putative 0.0222 0.0424 0.2459
Plasmodium falciparum thioredoxin reductase 0.0139 0.0256 0.8467
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.0002 0.0003
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0002 0.0034
Toxoplasma gondii patched family protein 0.0019 0.0014 0.0325
Schistosoma mansoni ferritin 0.0018 0.0012 0.0011
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.0002 0.0003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0098 0.3244
Entamoeba histolytica disulphide oxidoreductase, putative 0.0013 0.0001 0.0017
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0016 0.0366
Onchocerca volvulus 0.0054 0.0085 0.1858
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0197 0.0373 0.1937
Echinococcus multilocularis expressed conserved protein 0.0296 0.0572 0.0572
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0002 0.0007
Brugia malayi Patched related family protein 12 0.0019 0.0014 0.0071
Brugia malayi hypothetical protein 0.0019 0.0014 0.0072
Trypanosoma brucei heat shock protein, putative 0.0064 0.0104 0.2454
Schistosoma mansoni hypothetical protein 0.0146 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0082 0.0476
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0019 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0222 0.0424 0.0423
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0031 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0196 0.0195
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.023 0.0497
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.0189 0.4458
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0019 0.0422
Plasmodium falciparum glutathione reductase 0.0139 0.0256 0.8467
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0001 0.0001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0048 0.0073 0.1713
Entamoeba histolytica hypothetical protein 0.0109 0.0196 0.3203
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0012 0.0342
Echinococcus multilocularis musashi 0.0054 0.0085 0.0084
Brugia malayi hypothetical protein 0.0021 0.0017 0.0089
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0031 0.0157
Plasmodium falciparum endoplasmin, putative 0.0039 0.0054 0.18
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0042 0.0042
Brugia malayi MH1 domain containing protein 0.0018 0.0012 0.0062
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0087 0.0503
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0013 0.0001 0.0001
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0104 0.2454
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0222 0.0424 0.2203
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0318 0.0616 0.134
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0034 0.0175
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.0049 0.0075 0.0388
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0001 0.0006
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0017 0.0017
Loa Loa (eye worm) TAR-binding protein 0.0211 0.04 0.2082
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0002 0.0034
Trypanosoma brucei unspecified product 0.002 0.0016 0.0366
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0078 0.1835
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0013 0.0001 0.0058
Echinococcus granulosus RUN 0.0019 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0222 0.0424 0.2203
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0064 0.0105 0.2484
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0003 0.0071
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0044 0.1039
Schistosoma mansoni tar DNA-binding protein 0.0211 0.04 0.04
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0183 0.0183
Trypanosoma cruzi heat shock protein, putative 0.0026 0.0028 0.066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0211 0.04 0.2082
Echinococcus granulosus endoplasmin 0.0051 0.0078 0.0078
Trypanosoma brucei polo-like protein kinase 0.0103 0.0183 0.4316
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0189 0.6238
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0019 0.0422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.0405 0.2107
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.0002 0.0003
Giardia lamblia Glutamate synthase 0.0013 0.0001 0.0058
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.0002 0.0042
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.023 0.3765
Loa Loa (eye worm) hypothetical protein 0.0162 0.0303 0.1573
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0056 0.0056
Brugia malayi Niemann-Pick C1 protein precursor 0.0315 0.061 0.3175
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0002 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0098 0.2318
Schistosoma mansoni ferritin 0.0018 0.0012 0.0011
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0031 0.0715
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0102 0.2395
Echinococcus multilocularis lamin 0.0054 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0054 0.0085 0.0438
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0098 0.3237
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0084 0.0083
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0026 0.0605
Treponema pallidum oxidoreductase 0.0013 0.0001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0072
Schistosoma mansoni apoferritin-2 0.0018 0.0012 0.0011
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0031 0.0715
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.0002 0.0001
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0035 0.0045 0.1064
Loa Loa (eye worm) hypothetical protein 0.0301 0.0583 0.303
Leishmania major NADH dehydrogenase, putative 0.0013 0.0001 0.0025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0096 0.2249
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0001 0.0025
Schistosoma mansoni hypothetical protein 0.124 0.2476 0.2476
Echinococcus granulosus Niemann Pick C1 protein 0.0315 0.061 0.061
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0067 0.0111 0.0577
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Schistosoma mansoni ferritin light chain 0.0018 0.0012 0.0011
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.023 0.0497
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.082 0.082
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.266 0.5339 0.5339
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.023 0.05
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0019 0.0019
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0014 0.0468
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0305 0.059 0.059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0073 0.1713
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0096 0.0095
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0019 0.0099
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.0002 0.0013
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0013 0.0001 0.0003
Echinococcus multilocularis lamin dm0 0.0054 0.0085 0.0084
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0026 0.0026
Schistosoma mansoni endoplasmin 0.0064 0.0104 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.023 0.1334
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0098 0.0098
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0035 0.0045 0.1064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0013 0.0001 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0305 0.059 0.059
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0019 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0161 0.03 0.03
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0036 0.0036
Echinococcus multilocularis dna polymerase kappa 0.002 0.0016 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0061 0.006
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0078 0.4252
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0017 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0037 0.0865
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0035 0.0047 0.0243
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.0257 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0305 0.059 0.059
Mycobacterium ulcerans putative regultory protein 0.0013 0.0002 0.0001
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0028 0.0458
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Entamoeba histolytica heat shock protein 90, putative 0.0064 0.0104 0.1703
Treponema pallidum heat shock protein 90 0.0051 0.0078 0.2569
Brugia malayi nuclear receptor NHR-88 0.0022 0.0019 0.0099
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0107 0.0556
Loa Loa (eye worm) beta-lactamase 0.0222 0.0424 0.2203
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Giardia lamblia NADH oxidase lateral transfer candidate 0.0048 0.0073 0.3969
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0001 0.0025
Entamoeba histolytica protein kinase rad3, putative 0.002 0.0015 0.0239
Mycobacterium ulcerans transcriptional regulator 0.2296 0.4605 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0028 0.0028
Toxoplasma gondii NADPH-glutathione reductase 0.0048 0.0073 0.1713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0019 0.0099
Brugia malayi hypothetical protein 0.0109 0.0196 0.1017
Plasmodium falciparum thioredoxin reductase 0.0048 0.0073 0.2406
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0013 0.0002 0.001
Echinococcus multilocularis cpg binding protein 0.0031 0.0038 0.0038
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0035 0.0047 0.0243
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0121 0.0627
Echinococcus multilocularis heat shock protein 90 0.0051 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0019 0.0099
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0013 0.0001 0.0002
Brugia malayi CHD4 protein 0.0013 0.0003 0.0012
Onchocerca volvulus 0.0019 0.0014 0.0303
Trichomonas vaginalis DNA topoisomerase II, putative 0.0013 0.0002 0.0008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0016 0.0015
Leishmania major DNA polymerase eta, putative 0.002 0.0016 0.0366
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0001 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.019
Onchocerca volvulus 0.0197 0.0373 0.8215
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.0002 0.0034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0013 0.0072
Loa Loa (eye worm) hypothetical protein 0.0135 0.0248 0.1289
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0366
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.0002 0.0001
Brugia malayi Patched related family protein 10 0.0019 0.0014 0.0071
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0013 0.0002 0.0002
Echinococcus granulosus glutamate synthase 0.0013 0.0001 0.0001
Brugia malayi beta-lactamase family protein 0.0222 0.0424 0.2203
Onchocerca volvulus 0.0019 0.0014 0.0303
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0096 0.2249
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0013 0.0002 0.0002
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0315 0.061 0.3175
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0145
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0017 0.0017
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0063 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0064 0.0369
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0025
Toxoplasma gondii target of rapamycin (TOR), putative 0.0053 0.0082 0.1936
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0001 0.0006
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0044 0.1464
Echinococcus granulosus expressed protein 0.0013 0.0002 0.0002
Schistosoma mansoni ferritin 0.0018 0.0012 0.0011
Brugia malayi CCR4 0.0013 0.0001 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0483 0.0949 0.4936
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0019 0.0019
Schistosoma mansoni ets-related 0.0239 0.0457 0.0457
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0012 0.0022
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0036 0.0036
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0019 0.0111
Toxoplasma gondii exonuclease III APE 0.0061 0.0098 0.2312
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0019 0.0099
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0013 0.0002 0.0009
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0003 0.0012
Brugia malayi MH2 domain containing protein 0.0033 0.0042 0.0216
Brugia malayi hypothetical protein 0.0966 0.1922 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0017 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0028 0.0028
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.0002 0.0001
Brugia malayi phosphofructokinase 0.0126 0.023 0.1195
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0105 0.0547
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0 0.0011
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0013 0.0002 0.0002
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.0002 0.0001
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.0002 0.0001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0001 0.0006
Trypanosoma brucei heat shock protein 90, putative 0.0064 0.0104 0.2454
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0017 0.0089
Entamoeba histolytica thioredoxin reductase, putative 0.0013 0.0001 0.0017
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0048 0.0073 0.1713
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.009 0.2121
Trichomonas vaginalis D-aminoacylase, putative 0.0222 0.0424 0.2459
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0305 0.059 0.3069
Echinococcus multilocularis smad 0.0033 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0315
Schistosoma mansoni glutamate synthase 0.0013 0.0001 0.0001
Brugia malayi Heterochromatin protein 1 0.0072 0.0121 0.0627
Trichomonas vaginalis glutaminase, putative 0.0866 0.1722 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0366
Echinococcus multilocularis muscleblind protein 1 0.0301 0.0583 0.0582
Echinococcus granulosus smad 0.0033 0.0042 0.0042
Trypanosoma brucei protein kinase, putative 0.0059 0.0096 0.2249
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0033 0.0783
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0079 0.0456
Echinococcus granulosus expressed protein 0.0405 0.0791 0.0791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0047 0.027
Brugia malayi FAT domain containing protein 0.0015 0.0006 0.003
Mycobacterium tuberculosis Probable lipase LipD 0.0222 0.0424 0.0921
Trypanosoma brucei heat shock protein, putative 0.0064 0.0104 0.2454
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0002 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0305 0.059 0.059
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0036 0.0036
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2296 0.4605 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0087 0.0503
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0064 0.0064
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2296 0.4605 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0019 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0013 0.0072
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.0002 0.0003
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0014 0.0014
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0019 0.0019
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0013 0.0001 0.0001
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.0002 0.0001
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0098 0.5357
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0019 0.0019
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0102 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0099
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0001 0.0025
Toxoplasma gondii patched family protein 0.0019 0.0014 0.0325
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0017 0.0017
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0073 0.1713
Schistosoma mansoni cellular tumor antigen P53 0.0159 0.0296 0.0296
Brugia malayi Muscleblind-like protein 0.0301 0.0583 0.303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0305 0.059 0.059
Schistosoma mansoni survival motor neuron protein 0.0197 0.0373 0.0372
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0019 0.0019
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0005 0.0124
Echinococcus multilocularis dna polymerase eta 0.002 0.0016 0.0015
Onchocerca volvulus 0.0013 0.0002 0.0036
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0002 0.0034
Treponema pallidum NADH oxidase 0.0048 0.0073 0.2398
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0019 0.0099
Brugia malayi Doublecortin family protein 0.0019 0.0014 0.0072
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.0002 0.0042
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0002 0.0002
Echinococcus multilocularis geminin 0.124 0.2476 0.2476
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0014 0.0014
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0017 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0044 0.0256
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0109 0.0196 0.0195
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0098 0.2312
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0031 0.0715
Brugia malayi MH2 domain containing protein 0.0033 0.0042 0.0216
Schistosoma mansoni glutamate synthase 0.0013 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0005 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0056 0.0056
Mycobacterium tuberculosis Conserved protein 0.0222 0.0424 0.0921
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0096 0.0095
Echinococcus granulosus dna polymerase kappa 0.002 0.0016 0.0015
Onchocerca volvulus Alhambra homolog 0.0032 0.0039 0.0859
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0013 0.0002 0.0002
Trichomonas vaginalis sensor histidine kinase, putative 0.0013 0.0002 0.0008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0005 0.0108
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0002 0.0002
Chlamydia trachomatis glutamine binding protein 0.0024 0.0024 0.0745
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0037 0.0037
Trypanosoma brucei heat shock protein 84, putative 0.0026 0.0028 0.066
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Mycobacterium ulcerans hypothetical protein 0.0222 0.0424 0.0917
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0031 0.1655
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0067 0.0112 0.0111
Toxoplasma gondii patched family protein 0.0019 0.0014 0.0325
Brugia malayi Thioredoxin reductase 0.0139 0.0256 0.1332
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0002 0.0008
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0048 0.0073 0.0155
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0162 0.0303 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0099
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.0002 0.0034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0089
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0013 0.0001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Entamoeba histolytica hypothetical protein 0.0109 0.0196 0.3203
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0044 0.0256
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0031 0.0157
Onchocerca volvulus 0.0019 0.0014 0.0303
Trypanosoma cruzi hypothetical protein, conserved 0.0222 0.0424 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0318 0.0616 0.134
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0013 0.0002 0.001
Onchocerca volvulus 0.0222 0.0424 0.9341
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0026 0.0026
Trypanosoma brucei unspecified product 0.0014 0.0003 0.0071
Echinococcus multilocularis thioredoxin glutathione reductase 0.014 0.0257 0.0257
Brugia malayi kinase, mitochondrial precursor 0.0013 0.0002 0.0007
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0162 0.0303 1
Brugia malayi beta-lactamase 0.0222 0.0424 0.2203
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.0002 0.0003
Echinococcus granulosus geminin 0.124 0.2476 0.2476
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.0002 0.0032
Echinococcus granulosus bloom syndrome protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0112 0.0579
Schistosoma mansoni smad 0.0015 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0222 0.0424 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.0002 0.0003
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0001 0.0025
Toxoplasma gondii thioredoxin reductase 0.0139 0.0256 0.6047
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0079 0.0456
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.023 0.023
Schistosoma mansoni niemann-pick C1 (NPC1) 0.032 0.062 0.062
Brugia malayi Myosin head containing protein 0.0019 0.0014 0.0071
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.0002 0.0003
Echinococcus granulosus tar DNA binding protein 0.0211 0.04 0.04
Echinococcus granulosus survival motor neuron protein 1 0.0966 0.1922 0.1922
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0044 0.0256
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0015 0.0076
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0019 0.0019
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0002 0.0001
Echinococcus multilocularis protein dispatched 1 0.0154 0.0286 0.0286
Mycobacterium tuberculosis Conserved protein 0.0222 0.0424 0.0921
Loa Loa (eye worm) fli-1 protein 0.0239 0.0457 0.2376
Echinococcus granulosus expressed protein 0.0018 0.0012 0.0011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0318 0.0616 0.134
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0013 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0106 0.0189 0.0981
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0026 0.0026
Brugia malayi 6-phosphofructokinase 0.0126 0.023 0.1195
Echinococcus granulosus muscleblind protein 0.0301 0.0583 0.0582
Brugia malayi Glutamate receptor 1 precursor 0.0025 0.0026 0.0136
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0017 0.0017
Trypanosoma brucei heat shock protein, putative 0.0064 0.0104 0.2454
Leishmania major hypothetical protein, conserved 0.0106 0.0189 0.4454
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0019 0.0098
Schistosoma mansoni GTP-binding protein alpha subunit 0.0013 0.0002 0.0002
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0099
Mycobacterium ulcerans beta-lactamase 0.0222 0.0424 0.0917
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0048 0.0073 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0183 0.1061
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0026 0.0028 0.0617
Giardia lamblia DINP protein human, muc B family 0.002 0.0016 0.0847
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0013 0.0001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0388
Loa Loa (eye worm) patched family protein 0.0019 0.0014 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0013 0.0072
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0024 0.0024 0.0745
Leishmania major hypothetical protein, conserved 0.0013 0.0001 0.0025
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0044 0.1039
Loa Loa (eye worm) transcription factor SMAD2 0.0483 0.0949 0.4936
Schistosoma mansoni apoferritin-2 0.0018 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0064 0.0369
Schistosoma mansoni tar DNA-binding protein 0.0211 0.04 0.04
Brugia malayi Bromodomain containing protein 0.0032 0.0039 0.0203
Schistosoma mansoni lipoxygenase 0.0054 0.0084 0.0083
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Echinococcus granulosus sterol regulatory element binding protein 0.0135 0.0248 0.0248
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0012 0.0376
Giardia lamblia Grp94/Hsp90 0.0051 0.0078 0.4252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0007 0.0041
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.0189 0.4454
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.0183 0.0183
Echinococcus multilocularis expressed protein 0.0013 0.0002 0.0002
Toxoplasma gondii patched family protein 0.0019 0.0014 0.0325
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0078 0.1835
Brugia malayi jmjC domain containing protein 0.004 0.0056 0.029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0222 0.0424 0.0917
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0064 0.0105 0.2484
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0017 0.0089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0013 0.0013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0007 0.0036
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0016 0.0081
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.023 0.023
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0013 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0098 0.0569
Schistosoma mansoni smad 0.0033 0.0042 0.0042
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0082 0.0476
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.0002 0.0048
Brugia malayi hypothetical protein 0.0019 0.0014 0.0071
Schistosoma mansoni microtubule-associated protein tau 0.4972 1 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0001 0.0006
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0031 0.0176
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0098 0.0213
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0035 0.0045 0.0045
Trypanosoma brucei heat shock protein, putative 0.0064 0.0104 0.2454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0045 0.0262
Brugia malayi PXA domain containing protein 0.0021 0.0017 0.0089
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0013 0.0001 0.0046
Onchocerca volvulus 0.0019 0.0014 0.0304
Trichomonas vaginalis endoplasmin, putative 0.0039 0.0054 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0099
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0054 0.0315
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0102 0.0101
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0301 0.0583 0.303
Toxoplasma gondii ABC1 family protein 0.0222 0.0424 1
Mycobacterium leprae conserved hypothetical protein 0.0222 0.0424 0.0917
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0017 0.0089
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0006
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0001 0.0006
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0013 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0045 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0069 0.0396
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0017 0.0017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0096 0.2249
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0102 0.0101
Plasmodium vivax heat shock protein 90, putative 0.0026 0.0028 0.0667
Echinococcus granulosus nmda type glutamate receptor 0.0033 0.0043 0.0042
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0064 0.0105 0.0105
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.0183 0.4032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0048 0.0073 0.0073
Brugia malayi hypothetical protein 0.0019 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0172
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0035 0.018
Plasmodium falciparum glutathione reductase 0.0048 0.0073 0.2406
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0002 0.0009
Entamoeba histolytica DNA topoisomerase II, putative 0.0013 0.0002 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0073 0.1713
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0099
Loa Loa (eye worm) RecQ helicase 0.0022 0.0019 0.01
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.0002 0.0003
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Echinococcus granulosus chromobox protein 1 0.0072 0.0121 0.0121
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.0002 0.0001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0048 0.0073 0.1713
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0048 0.0073 0.1713
Onchocerca volvulus 0.0222 0.0424 0.9341
Leishmania major DNA polymerase kappa, putative 0.002 0.0016 0.0366
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0017 0.0017
Echinococcus granulosus dna polymerase eta 0.002 0.0016 0.0015
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Loa Loa (eye worm) patched family protein 0.0019 0.0014 0.0071
Brugia malayi CXXC zinc finger family protein 0.0029 0.0035 0.018
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0035 0.0047 0.11
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0019 0.0099
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0051 0.0078 0.0169
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0048 0.0073 0.2406
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0085 0.0438
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0031 0.003
Giardia lamblia Thioredoxin reductase 0.0013 0.0001 0.0058
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0013 0.0001 0.0017
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0183 0.4316
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0026 0.0026
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0002 0.0034
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0014 0.0014
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0002 0.0002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0016 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0098 0.0098
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0001 0.0006
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0015 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0073 0.1713
Echinococcus granulosus tumor protein p63 0.1085 0.2164 0.2164
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0196 0.0195
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.0183 0.4316
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0017 0.0017
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0012 0.0025
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.0078 0.1835
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0001 0.0001
Echinococcus granulosus serine protein kinase ATM 0.0035 0.0047 0.0047
Echinococcus multilocularis microtubule associated protein 2 0.4972 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0044 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0001 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0037 0.0037
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0017 0.0017
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0184 0.0184
Loa Loa (eye worm) nuclear factor I 0.0018 0.0012 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0183 0.1061
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.023 0.023
Brugia malayi MH1 domain containing protein 0.0033 0.0042 0.0216
Brugia malayi steroid hormone receptor 0.0022 0.0019 0.0099
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0057 0.1251
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0 0.0011
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0162 0.0303 0.7143
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Schistosoma mansoni lamin 0.0054 0.0085 0.0084
Mycobacterium tuberculosis Probable reductase 0.0318 0.0616 0.134
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0013 0.0001 0.0001
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0002 0.0008
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0001 0.0006
Schistosoma mansoni hypothetical protein 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Leishmania major heat shock protein, putative 0.0026 0.0028 0.066
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0366
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.0183 0.0951
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0006
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0013 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0019 0.0099
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0222 0.0424 0.0921
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0002 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0019 0.0099
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0044 0.0721
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Plasmodium falciparum heat shock protein 90 0.0064 0.0104 0.3443
Loa Loa (eye worm) patched family protein 0.0019 0.0014 0.0071
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0183 0.4316
Brugia malayi heat shock protein 90 0.0064 0.0104 0.0541
Plasmodium vivax SET domain protein, putative 0.003 0.0037 0.0872
Leishmania major phosphatidylinositol 3-kinase, putative 0.0035 0.0045 0.1064
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0112 0.0111
Trichomonas vaginalis glutathione reductase, putative 0.0048 0.0073 0.0421
Plasmodium falciparum lipid/sterol:H+ symporter 0.0019 0.0014 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0019 0.0099
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0353 0.0687 0.1495
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0019 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0057 0.0329
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0016 0.0081
Echinococcus multilocularis survival motor neuron protein 1 0.0966 0.1922 0.1922
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0013 0.0072
Brugia malayi Patched protein homolog 1 0.0019 0.0014 0.0071
Echinococcus multilocularis peptidase Clp (S14 family) 0.0106 0.019 0.019
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0017 0.0017
Echinococcus granulosus ferritin 0.0018 0.0012 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0005 0.0025
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0053 0.0052
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0019 0.0019
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0013 0.0001 0.0025
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.023 0.5427
Loa Loa (eye worm) hypothetical protein 0.0222 0.0424 0.2203
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.023 0.5427
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0035 0.0047 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0111
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0013 0.0001 0.0006
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0013 0.0001 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0033 0.0033
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.0002 0.0034
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0024 0.0024 0.0778
Brugia malayi Ets-domain containing protein 0.0079 0.0134 0.0696
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0089
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0002 0.0034
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0019 0.0019
Brugia malayi intermediate filament protein 0.0054 0.0085 0.0438
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.003 0.0036 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0211 0.04 0.04
Trypanosoma cruzi Heat shock protein 83, putative 0.0064 0.0104 0.2454
Toxoplasma gondii hypothetical protein 0.0056 0.0088 0.2078
Schistosoma mansoni ap endonuclease 0.0061 0.0098 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0096 0.0553
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0388
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0013 0.0001 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0112 0.0111
Schistosoma mansoni cpg binding protein 0.0031 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.0002 0.0001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0064 0.0105 0.2484
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0031 0.0157
Loa Loa (eye worm) hypothetical protein 0.0213 0.0405 0.2107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0019 0.0019
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0014 0.0072
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0017 0.0089
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0089
Echinococcus multilocularis peregrin 0.0032 0.0039 0.0039
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0021 0.0487
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0088 0.2084
Schistosoma mansoni peptidase Clp (S14 family) 0.0162 0.0303 0.0302
Plasmodium falciparum ferrodoxin reductase-like protein 0.0013 0.0001 0.0046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0047 0.0242
Trypanosoma brucei heat shock protein, putative 0.0064 0.0104 0.2454
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.0002 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0102 0.0218
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0102 0.0101
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0044 0.1464
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0102 0.0218
Trichomonas vaginalis penicillin-binding protein, putative 0.0222 0.0424 0.2459
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0017 0.0017
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0036 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0189 0.4454
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.023 0.5427
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0009
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0017 0.0017
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0 0.0008
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.003 0.0036 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0161 0.03 0.03
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0162 0.0303 0.0302
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0031 0.0496
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0013 0.0001 0.0025
Schistosoma mansoni kinase 0.0053 0.0082 0.0081
Schistosoma mansoni hypothetical protein 0.0419 0.082 0.082
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0017 0.0017
Schistosoma mansoni ap endonuclease 0.0061 0.0098 0.0098
Mycobacterium tuberculosis Conserved protein 0.0222 0.0424 0.0921
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0315
Trypanosoma cruzi heat shock protein 90, putative 0.0064 0.0104 0.2454
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0315
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0005 0.0005
Schistosoma mansoni patched 1 0.0135 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0072
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0016 0.0366
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0096 0.2249
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.0098 0.3213
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0189 0.6238
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0055 0.0087 0.2049
Toxoplasma gondii heat shock protein HSP90 0.0064 0.0104 0.2454
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0002 0.0002
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0017 0.0099
Loa Loa (eye worm) glutathione reductase 0.0139 0.0256 0.1332
Echinococcus granulosus lamin dm0 0.0054 0.0085 0.0084
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0162 0.0303 0.0655
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0028 0.0934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0075 0.0434
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0001 0.0017
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0013 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Onchocerca volvulus 0.0019 0.0014 0.0303
Schistosoma mansoni hypothetical protein 0.0067 0.0112 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0061 0.0353
Entamoeba histolytica hypothetical protein 0.0109 0.0196 0.3203
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0019 0.0019
Echinococcus multilocularis chromobox protein 1 0.0072 0.0121 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0082 0.0476
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0112 0.0111
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0098 0.0509
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0002 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0037 0.0037
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.0002 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.0315 0.061 0.061
Trypanosoma brucei unspecified product 0.0014 0.0003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0064 0.0369
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0014 0.0014
Brugia malayi G-protein alpha subunit 0.0013 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0305 0.059 0.3069
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0098 0.2312
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0003 0.0002
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0044 0.0256
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0184 0.0184
Giardia lamblia PHD finger protein 15 0.0032 0.0039 0.2131
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0002 0.0042
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.0002 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0013 0.0072
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0042 0.0216
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0353 0.0687 0.149
Brugia malayi RNA binding protein 0.0211 0.04 0.2082
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0019 0.0098
Schistosoma mansoni DNA polymerase eta 0.002 0.0016 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0057 0.0326
Schistosoma mansoni hypothetical protein 0.0139 0.0257 0.0256
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0001 0.0006
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0013 0.0002 0.0009
Schistosoma mansoni glutamate synthase 0.0013 0.0001 0.0001
Brugia malayi glutathione reductase 0.0139 0.0256 0.1332
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.0002 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0098 0.0509
Giardia lamblia Heat shock protein HSP 90-alpha 0.0064 0.0104 0.5686
Brugia malayi glutaminase DH11.1 0.0866 0.1722 0.8958
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Brugia malayi MH1 domain containing protein 0.0033 0.0042 0.0216
Brugia malayi Glutamate receptor 2 precursor 0.0025 0.0026 0.0136
Brugia malayi Smad1 0.0033 0.0042 0.0216
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0039 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0104 0.0103
Brugia malayi hypothetical protein 0.0106 0.0189 0.0981
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0013 0.0002 0.0009
Onchocerca volvulus 0.0019 0.0014 0.0303
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0088 0.2916
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.0257 0.0256
Schistosoma mansoni glutaminase 0.0866 0.1722 0.1721
Onchocerca volvulus 0.0019 0.0014 0.0303
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0045 0.1064
Plasmodium falciparum phd finger protein, putative 0.0032 0.0039 0.1297
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0048 0.0073 0.0073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0019 0.0099
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0013 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0051 0.0078 0.2543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0082 0.0476
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0019 0.0019
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0017 0.0017
Plasmodium vivax heat shock protein, putative 0.0026 0.0028 0.0667
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0098 0.1604
Loa Loa (eye worm) patched family protein 0.0019 0.0014 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0033 0.0191
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0089
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0183 0.1061
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0048 0.0073 0.172
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0044 0.1425
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0022 0.0019 0.0451
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Schistosoma mansoni hypothetical protein 0.0067 0.0112 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0003 0.0071
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Plasmodium vivax endoplasmin, putative 0.0064 0.0104 0.246
Loa Loa (eye worm) amino acid permease 0.0049 0.0075 0.0388
Schistosoma mansoni Smad4 0.0015 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0052 0.0299
Schistosoma mansoni chromobox protein 0.0072 0.0121 0.0121
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0019 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0019 0.0019
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Echinococcus granulosus Protein patched homolog 1 0.0135 0.0248 0.0248
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0044 0.1046
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0388
Loa Loa (eye worm) hypothetical protein 0.0222 0.0424 0.2203
Brugia malayi hypothetical protein 0.0019 0.0014 0.0072
Schistosoma mansoni hypothetical protein 0.013 0.0238 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0052 0.0299
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0044 0.1425
Echinococcus multilocularis glutamate receptor 2 0.003 0.0036 0.0036
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0098 0.2312
Brugia malayi CHE-14 protein 0.0135 0.0248 0.1289
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0048 0.0073 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0211 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0089
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0013 0.0001 0.0006
Schistosoma mansoni ferritin 0.0018 0.0012 0.0011
Entamoeba histolytica hypothetical protein 0.0021 0.0017 0.0281
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0295
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0071 0.0071
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.023 0.023
Onchocerca volvulus 0.0022 0.0019 0.0422
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0045 0.0262
Brugia malayi hypothetical protein 0.0021 0.0017 0.0089
Echinococcus granulosus cpg binding protein 0.0031 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.013 0.0238 0.0238
Schistosoma mansoni Smad4 0.0015 0.0005 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0222 0.0424 0.2459
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0006 0.0033
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.0002 0.0001
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Leishmania major DNA topoisomerase ii 0.0013 0.0002 0.0034
Echinococcus granulosus lamin 0.0054 0.0085 0.0084
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0078 0.0451
Brugia malayi Probable ClpP-like protease 0.0162 0.0303 0.1573
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Trichomonas vaginalis chaperonin, putative 0.0027 0.0031 0.0176
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0388
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0001 0.0025
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0015 0.0006 0.0006
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0019 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0366
Mycobacterium tuberculosis Probable oxidoreductase 0.0353 0.0687 0.1495
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0183 0.1061
Loa Loa (eye worm) patched family protein 0.0019 0.0014 0.0071
Brugia malayi glutamate synthase 0.0013 0.0001 0.0006
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0013 0.0002 0.0002
Brugia malayi Ets-domain containing protein 0.0079 0.0134 0.0696
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0031 0.003
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0035 0.0045 0.0045
Echinococcus granulosus beta LACTamase domain containing family member 0.0222 0.0424 0.0423
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0016 0.0031
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0071 0.0071
Brugia malayi Amino acid permease family protein 0.0049 0.0075 0.0388
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0048 0.0073 0.2372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0082 0.0476
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0009
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0013 0.0001 0.0001
Mycobacterium leprae Probable lipase LipE 0.0222 0.0424 0.0917
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Schistosoma mansoni cpg binding protein 0.0031 0.0038 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0211 0.04 0.04
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0016 0.009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0048 0.0073 0.1713
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0013 0.0002 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0096 0.0553
Brugia malayi PHD-finger family protein 0.0032 0.0039 0.0203
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0039 0.092
Echinococcus multilocularis beta LACTamase domain containing family member 0.0222 0.0424 0.0423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0305 0.059 0.059
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0039 0.092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Entamoeba histolytica hypothetical protein 0.0035 0.0047 0.0763
Loa Loa (eye worm) RNA binding protein 0.0211 0.04 0.2082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0019 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0001 0.0025
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.0002 0.0001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0036 0.0036
Brugia malayi Patched related family protein 4 0.0019 0.0014 0.0071
Plasmodium vivax ferrodoxin reductase, putative 0.0013 0.0001 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0016 0.0081
Onchocerca volvulus 0.0013 0.0002 0.0036
Echinococcus multilocularis Smad4 0.0033 0.0042 0.0042
Plasmodium vivax heat shock protein 86, putative 0.0064 0.0104 0.246
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0001 0.0001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0098 0.021
Plasmodium vivax hypothetical protein, conserved 0.0222 0.0424 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0073 0.1713
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0045 0.0234
Loa Loa (eye worm) hypothetical protein 0.0146 0.0269 0.14
Echinococcus granulosus chromobox protein 1 0.0072 0.0121 0.0121
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0014 0.0333
Brugia malayi Fli-1 protein 0.0239 0.0457 0.2376
Schistosoma mansoni hypothetical protein 0.013 0.0238 0.0238
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0002 0.0034
Loa Loa (eye worm) thioredoxin reductase 0.0139 0.0256 0.1332
Schistosoma mansoni hypothetical protein 0.0032 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0019 0.0099
Brugia malayi protein C24B5.3 0.0019 0.0014 0.0071
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0042 0.0042
Toxoplasma gondii FATC domain-containing protein 0.0035 0.0047 0.11
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.0002 0.0034
Brugia malayi nuclear hormone receptor 0.0022 0.0019 0.0099
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0001 0.0001
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0001 0.0025
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0035 0.0045 0.1064
Loa Loa (eye worm) phosphofructokinase 0.0126 0.023 0.1195
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0019 0.0019
Schistosoma mansoni ferritin light chain 0.0018 0.0012 0.0011
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0002 0.0001
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0051 0.0078 0.0166
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0013 0.0002 0.0009
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0013 0.0001 0.0017
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0002 0.0013
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0013 0.0001 0.0006
Brugia malayi 6-phosphofructokinase 0.0126 0.023 0.1195
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0162 0.0303 0.0655
Trichomonas vaginalis heat shock protein, putative 0.0064 0.0104 0.0603
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0005 0.0108
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0085 0.0438
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0064 0.0105 0.1723
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0031 0.003
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0013 0.0002 0.0002
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0028 0.0162
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0002 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.045 0.0883 0.0883
Brugia malayi jmjC domain containing protein 0.0103 0.0184 0.0957
Schistosoma mansoni lipoxygenase 0.0019 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0096 0.0495
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0038 0.0888
Toxoplasma gondii Hsp90 domain-containing protein 0.0026 0.0028 0.066
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0013 0.0002 0.0009
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.0002 0.0013
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0134 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0045 0.0262
Schistosoma mansoni chromobox protein 0.0072 0.0121 0.0121
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0017 0.0017
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.0049 0.0075 0.0075
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0162 0.0303 0.0655
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0035 0.0047 0.0047
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0035 0.0045 0.0045
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0048 0.0073 0.1713
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0013 0.0001 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0034 0.0175
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0026 0.0026
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0203
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0048 0.0073 0.2372
Mycobacterium ulcerans heat shock protein 90 0.0051 0.0078 0.0166
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0388
Entamoeba histolytica G protein alpha subunit, putative 0.0013 0.0002 0.0027
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0045 0.1064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Entamoeba histolytica hypothetical protein 0.0021 0.0017 0.0281
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0026 0.0026
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0013 0.0001 0.0002
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.0002 0.0058
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0315
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0002 0.0013
Echinococcus multilocularis GPCR, family 2 0.0067 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0112 0.0579
Trypanosoma brucei heat shock protein, putative 0.0064 0.0104 0.2454
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0078 0.0451
Echinococcus multilocularis heat shock protein 90 0.0064 0.0104 0.0104
Echinococcus granulosus thioredoxin glutathione reductase 0.014 0.0257 0.0257
Mycobacterium ulcerans glutaminase 0.0866 0.1722 0.3737
Loa Loa (eye worm) programmed cell death 8 0.0013 0.0001 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0002 0.0007
Mycobacterium ulcerans esterase/lipase LipP 0.0222 0.0424 0.0917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0087 0.0503
Mycobacterium tuberculosis Conserved protein 0.0013 0.0002 0.0003
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0017 0.0089
Schistosoma mansoni smad1 5 8 and 0.0033 0.0042 0.0042
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0096 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0052 0.0299
Toxoplasma gondii heat shock protein 75, putative 0.0026 0.0028 0.066
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0096 0.0095
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Brugia malayi SET domain containing protein 0.0014 0.0003 0.0013
Brugia malayi TAR-binding protein 0.0211 0.04 0.2082
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0081
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0013 0.0001 0.0002
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0001 0.0046
Loa Loa (eye worm) hypothetical protein 0.0053 0.0083 0.0428
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0016 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Brugia malayi MH1 domain containing protein 0.0018 0.0012 0.0062
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.023 0.1334
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.002 0.0015 0.0239
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0162 0.0303 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0388
Loa Loa (eye worm) Smad1 0.0033 0.0042 0.0216
Echinococcus granulosus heat shock protein 90 0.0064 0.0104 0.0104
Echinococcus multilocularis solute carrier family 12 0.0049 0.0075 0.0075
Onchocerca volvulus 0.0159 0.0296 0.6522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0073 0.1713
Trichomonas vaginalis apoptosis inducing factor, putative 0.0013 0.0001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0064 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0087 0.0503
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.0002 0.0001
Toxoplasma gondii hypothetical protein 0.0019 0.0014 0.0325
Schistosoma mansoni polycystin 1-related 0.0019 0.0014 0.0014
Schistosoma mansoni loxhd1 0.0019 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0019 0.0099
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0019 0.0098
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0048 0.0073 0.1713
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0028 0.0934
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0013 0.0072
Echinococcus granulosus peregrin 0.0032 0.0039 0.0039
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0017 0.0017
Onchocerca volvulus 0.0013 0.0001 0.0023
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0033 0.0191
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0075 0.0388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0396 0.2057
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.0002 0.0001
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0013 0.0002 0.0008
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0088 0.2909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0105 0.0611
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.0183 0.0951
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0019 0.0019
Echinococcus multilocularis expressed protein 0.0018 0.0012 0.0011
Mycobacterium ulcerans TetR family transcriptional regulator 0.2296 0.4605 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0002 0.001
Onchocerca volvulus 0.0054 0.0085 0.1858
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0048 0.0073 0.0158
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0048 0.0073 0.2372
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0016 0.0254
Brugia malayi RNA recognition motif domain containing protein 0.0211 0.04 0.2082
Trypanosoma brucei heat shock protein 90, putative 0.0064 0.0104 0.2454
Echinococcus multilocularis serine protein kinase ATM 0.0035 0.0047 0.0047
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0014 0.0466
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0039 0.0039
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0269 0.14
Trypanosoma brucei hypothetical protein, conserved 0.0222 0.0424 1
Giardia lamblia Pms1-like protein 0.0013 0.0002 0.0079
Plasmodium vivax patched family protein, putative 0.0019 0.0014 0.0332
Loa Loa (eye worm) hypothetical protein 0.0222 0.0424 0.2203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0045 0.0262
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.0183 0.2995
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0015 0.0015
Plasmodium vivax glutathione reductase, putative 0.0139 0.0256 0.605
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0031 0.0715
Brugia malayi hypothetical protein 0.0013 0.0002 0.0009
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0013 0.0002 0.0002
Brugia malayi Patched family protein 0.0019 0.0014 0.0071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0196 0.0195
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0031 0.0722
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.003
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0064 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0248 0.1439
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0005 0.0005
Echinococcus granulosus GPCR family 2 0.0067 0.0112 0.0111
Mycobacterium tuberculosis Probable esterase LipL 0.0222 0.0424 0.0921
Entamoeba histolytica hypothetical protein 0.0021 0.0017 0.0281
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0106 0.019 0.0413
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0096 0.0095
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0002 0.0034
Echinococcus multilocularis nmda type glutamate receptor 0.0033 0.0043 0.0042
Brugia malayi Endoplasmin precursor 0.0064 0.0104 0.0541
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0183 0.1061
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0028 0.0028
Mycobacterium tuberculosis Probable lipase LipE 0.0222 0.0424 0.0921
Schistosoma mansoni heat shock protein 0.0064 0.0104 0.0104
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0001 0.0025
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0019 0.0422
Onchocerca volvulus 0.0237 0.0453 1
Loa Loa (eye worm) glutaminase 2 0.0866 0.1722 0.8958
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0019 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0121 0.07
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Brugia malayi hypothetical protein 0.0068 0.0113 0.0588
Entamoeba histolytica hypothetical protein 0.0109 0.0196 0.3203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0064 0.0369
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0039 0.0039
Onchocerca volvulus 0.0222 0.0424 0.9341
Trypanosoma brucei NADH dehydrogenase 0.0013 0.0001 0.0025
Echinococcus multilocularis heat shock protein 0.0064 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0222 0.0424 0.2203
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0353 0.0687 0.1495
Mycobacterium tuberculosis Possible penicillin-binding protein 0.142 0.2838 0.6175
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Echinococcus multilocularis RUN 0.0019 0.0014 0.0014
Brugia malayi beta-lactamase family protein 0.0222 0.0424 0.2203
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0222 0.0424 0.0423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Schistosoma mansoni intermediate filament proteins 0.0054 0.0085 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0019 0.0099
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0315
Brugia malayi ecdysteroid receptor 0.0022 0.0019 0.0099
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.0002 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0007 0.0036
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0039 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0015 0.0085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0112 0.0111
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0162 0.0303 0.7143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0085 0.0438
Echinococcus multilocularis thyroid hormone receptor alpha 0.0161 0.03 0.03
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0002 0.0032
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0013 0.0002 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0048 0.0073 0.1713
Leishmania major hypothetical protein, conserved 0.0013 0.0001 0.0025
Trypanosoma brucei trypanothione reductase 0.0139 0.0256 0.6047
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0013 0.0002 0.0009
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0012 0.0022
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0013 0.0002 0.001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0036 0.0036
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0019 0.0099
Brugia malayi hypothetical protein 0.0019 0.0014 0.0071
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.023 0.3765
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2292 0.4596 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0003 0.0002
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0064 0.0105 0.2484
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0044 0.2407
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0002 0.0034
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.023 0.7597
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0019 0.0019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0019 0.0019
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0017 0.0089
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0017 0.0017
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0013 0.0002 0.0008
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0002 0.0007
Schistosoma mansoni cpg binding protein 0.0029 0.0035 0.0035
Schistosoma mansoni rab6-interacting 0.0019 0.0014 0.0014
Loa Loa (eye worm) glutaminase 0.0866 0.1722 0.8958
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0017 0.0089
Schistosoma mansoni gabp alpha 0.0079 0.0134 0.0134
Leishmania major phosphatidylinositol kinase related protein, putative 0.0023 0.0021 0.0487
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0005 0.0005
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0016 0.0015
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0106 0.019 0.0413
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0001 0.0006
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0001 0.0006
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0024 0.0024 0.0778
Loa Loa (eye worm) heat shock protein 90 0.0064 0.0104 0.0541
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0013 0.0002 0.0002
Onchocerca volvulus 0.0029 0.0035 0.0762
Loa Loa (eye worm) endoplasmin 0.0064 0.0104 0.0541
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0016 0.0034
Loa Loa (eye worm) hypothetical protein 0.0166 0.0309 0.1608
Plasmodium vivax thioredoxin reductase, putative 0.0139 0.0256 0.605
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0222 0.0424 0.0921
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0013 0.0002 0.0009
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0013 0.0002 0.0002
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0064 0.0064
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0016 0.0031
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0048 0.0073 0.0155
Toxoplasma gondii selenide, water dikinase 0.0013 0.0001 0.0025
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0019 0.0111
Mycobacterium tuberculosis Probable dehydrogenase 0.0318 0.0616 0.134
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0015 0.0345
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0102 0.2395
Onchocerca volvulus 0.0032 0.0039 0.0862
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.0002 0.0003
Giardia lamblia GTOR 0.0064 0.0105 0.5755
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0019 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0048 0.0073 0.1713
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0024 0.0024 0.0049
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0001 0.0025
Mycobacterium ulcerans lipase LipD 0.0222 0.0424 0.0917
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0026 0.0026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.0405 0.2107
Schistosoma mansoni rab6-interacting 0.0019 0.0014 0.0014
Echinococcus granulosus heat shock protein 90 0.0051 0.0078 0.0078
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.023 0.3765
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.0078 0.0078
Leishmania major heat shock protein 83-1 0.0064 0.0104 0.2454
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0318 0.0616 0.134
Echinococcus granulosus dnaJ subfamily B 0.0419 0.082 0.082
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0105 0.0547
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0001 0.0006
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0071
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0019 0.01
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0315
Brugia malayi PXA domain containing protein 0.0021 0.0017 0.0089
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0064 0.0105 0.2484
Trypanosoma brucei heat shock protein, putative 0.0064 0.0104 0.2454
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0037 0.0037
Brugia malayi MH2 domain containing protein 0.0015 0.0005 0.0025
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0134 0.0696
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0048 0.0073 0.2406
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0048 0.0073 0.0155
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0019 0.0019
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.013 0.0238 0.0238
Onchocerca volvulus 0.0042 0.0061 0.1332
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0019 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.023 0.1334
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0222 0.0424 0.2203
Onchocerca volvulus Protein patched homolog 0.0019 0.0014 0.0303
Schistosoma mansoni hypothetical protein 0.0047 0.0071 0.0071
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0014 0.0014
Echinococcus multilocularis chromobox protein 1 0.0072 0.0121 0.0121
Echinococcus granulosus heat shock protein 0.0064 0.0104 0.0104
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0104 0.2454
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0222 0.0424 0.2203
Loa Loa (eye worm) hypothetical protein 0.0966 0.1922 1
Echinococcus multilocularis ferritin 0.0018 0.0012 0.0011
Giardia lamblia Kinase, PLK 0.0103 0.0183 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0037 0.0037
Echinococcus multilocularis tumor protein p63 0.1085 0.2164 0.2164
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0318 0.0616 0.1335
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0019 0.0099
Schistosoma mansoni smad1 5 8 and 0.0033 0.0042 0.0042
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0042 0.0042
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0067 0.0112 0.0111
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0042 0.0042
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0096 0.2249
Plasmodium falciparum DNase I-like protein, putative 0.0012 0 0.0011
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0002 0.001
Leishmania major trypanothione reductase 0.0139 0.0256 0.6047
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.023 0.1334
Schistosoma mansoni endoplasmin 0.0064 0.0104 0.0104
Leishmania major hypothetical protein, conserved 0.0013 0.0002 0.0034
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0141 0.0141
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0013 0.0001 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0096 0.2249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0002 0.0007
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0453 0.2632
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0315 0.061 1
Entamoeba histolytica heat shock protein 90, putative 0.0064 0.0104 0.1703

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -9.676 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.31 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.244 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.241 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.168 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.123 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.071 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.942 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.902 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.721 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.647 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.64 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0052 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.013 uM PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.058 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 0.0891 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.