Detailed information for compound 934376

Basic information

Technical information
  • TDR Targets ID: 934376
  • Name: 4-[(Z)-4-ethylazaniumylbut-2-enyl]azaniumylbu tyl-[(Z)-4-(4-ethylazaniumylbutylazaniumyl)bu t-2-enyl]azanium pentachloride
  • MW: 535.894 | Formula: C20H48Cl5N5
  • H donors: 5 H acceptors: 0 LogP: 4.86 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCNCCCCNC/C=C\CNCCCCNC/C=C\CNCC.Cl.Cl.Cl.Cl.Cl
  • InChi: 1S/C20H43N5.5ClH/c1-3-21-13-5-7-15-23-17-9-11-19-25-20-12-10-18-24-16-8-6-14-22-4-2;;;;;/h5,7,10,12,21-25H,3-4,6,8-9,11,13-20H2,1-2H3;5*1H/b7-5-,12-10-;;;;;
  • InChiKey: GFXWKZOBFXHZCP-UTGRFYNFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(Z)-4-ethylammoniobut-2-enyl]ammoniobutyl-[(Z)-4-(4-ethylammoniobutylammonio)but-2-enyl]ammonium pentachloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase eta, putative 0.0079 0.0331 0.198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0128 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0067 0.0067
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0147 0.017
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.0489 0.0586
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0148
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0055 0.065
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0133 0.1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0045 0.324
Trypanosoma brucei trypanothione reductase 0.0037 0.0085 0.0497
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0376 0.2103 0.4746
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0359 0.0372
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0359 0.0776
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0078 0.0137
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0052
Plasmodium falciparum transporter, putative 0.0046 0.0136 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0083 0.6032
Brugia malayi DnaJ domain containing protein 0.0061 0.0228 0.0479
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0128 0.0251
Trypanosoma brucei protein kinase, putative 0.005 0.0159 0.0942
Echinococcus multilocularis caspase 0.0027 0.0021 0.0013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0085 0.102
Loa Loa (eye worm) DOMON domain-containing protein 0.0146 0.0733 0.1628
Echinococcus multilocularis caspase 8 0.0027 0.0021 0.0013
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.01 0.7328
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Plasmodium falciparum metacaspase 1 0.0027 0.0021 0.1406
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0041 0.0108 0.0106
Plasmodium vivax JmjC domain containing protein 0.0041 0.0108 0.7939
Onchocerca volvulus 0.0046 0.0136 0.0584
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0105 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0047 0.0047
Brugia malayi hypothetical protein 0.0037 0.0083 0.0148
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0369 0.4534
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.0067 0.081
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0046 0.0136 0.0157
Brugia malayi PHD-finger family protein 0.0029 0.0036 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0566 0.3233 0.3929
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0009 0.0082
Echinococcus granulosus muscleblind protein 0.0154 0.0779 0.0938
Trypanosoma brucei unspecified product 0.0073 0.0299 0.1783
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0085 0.6163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0128 0.0146
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0083 0.0457
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0009 0.0013
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0105 0.0489 0.293
Plasmodium vivax metacaspase 1, putative 0.0027 0.0021 0.1406
Brugia malayi hypothetical protein 0.0105 0.0489 0.1073
Mycobacterium ulcerans aminopeptidase N PepN 0.0105 0.0489 0.6017
Brugia malayi Cytochrome P450 family protein 0.0054 0.0187 0.0384
Brugia malayi DOMON domain containing protein 0.0146 0.0733 0.1628
Schistosoma mansoni hypothetical protein 0.0333 0.1843 0.2172
Brugia malayi Cytochrome P450 family protein 0.0034 0.0067 0.0113
Mycobacterium ulcerans hypothetical protein 0.0025 0.0009 0.0082
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0021 0.0083
Schistosoma mansoni jumonji domain containing protein 0.0196 0.1027 0.1209
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0105 0.0489 0.0511
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0148
Loa Loa (eye worm) hypothetical protein 0.0271 0.1474 0.3316
Echinococcus granulosus aminopeptidase N 0.0358 0.1993 0.2417
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0077 0.0423
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0147 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0021 0.011
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0067 0.0113
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0159 0.0914
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0271 0.1474 0.3316
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0046 0.0136 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0078 0.0565
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0108 0.0206
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0085 0.0152
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0136 0.0269
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.0179 0.0208
Schistosoma mansoni sodium-dependent amino acid transporter 0.0046 0.0136 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0078 0.0429
Onchocerca volvulus 0.0046 0.0136 0.0584
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0835 0.1007
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0018 0.001
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0067 0.0113
Brugia malayi jmjC domain containing protein 0.0041 0.0108 0.0206
Echinococcus multilocularis sodium and chloride dependent glycine 0.0046 0.0136 0.0135
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.0067 0.081
Schistosoma mansoni inositol monophosphatase 0.0036 0.0077 0.0088
Echinococcus granulosus dna polymerase eta 0.0079 0.0331 0.0393
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0359 0.0427
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0046 0.0136 0.0269
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0159 0.0914
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0068 0.0269 0.0314
Toxoplasma gondii thioredoxin reductase 0.0037 0.0085 0.0085
Trypanosoma brucei unspecified product 0.0037 0.0081 0.0474
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0078 0.0565
Loa Loa (eye worm) hypothetical protein 0.0031 0.0047 0.0066
Plasmodium vivax glutathione reductase, putative 0.0037 0.0085 0.6163
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0116 0.0685
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0159 0.0184
Echinococcus granulosus leukotriene A 4 hydrolase 0.0037 0.0083 0.009
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0083 0.0457
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0147 0.0169
Brugia malayi MAP kinase sur-1 0.005 0.0159 0.032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0369 0.4534
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.0067 0.081
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0021 0.011
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.1008 0.1062
Onchocerca volvulus 0.0236 0.1267 0.6322
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0078 0.0565
Loa Loa (eye worm) cytochrome P450 0.0034 0.0067 0.0113
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0083 0.009
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0105 0.0489 0.0574
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0159 0.0183
Schistosoma mansoni hypothetical protein 0.0048 0.0148 0.0172
Echinococcus multilocularis neuropeptide s receptor 0.0566 0.3233 0.3427
Loa Loa (eye worm) TATA binding protein associated factor 0.0037 0.0083 0.0148
Schistosoma mansoni alpha glucosidase 0.0036 0.0078 0.0089
Trypanosoma cruzi metacaspase, putative 0.0027 0.0021 0.0083
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0067 0.0363
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0105 0.0489 0.0574
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0078 0.0074
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1665 1
Plasmodium vivax amine transporter, putative 0.0046 0.0136 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0271 0.1474 0.1737
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0147 0.0169
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0426 0.5232
Plasmodium vivax SET domain protein, putative 0.0031 0.0045 0.3223
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0445 0.0973
Toxoplasma gondii aminopeptidase n, putative 0.0037 0.0083 0.0083
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0147 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0021 0.011
Echinococcus granulosus lysine specific demethylase 6a 0.0041 0.0108 0.0122
Trypanosoma cruzi metacaspase, putative 0.0027 0.0021 0.0083
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0215 0.1144 0.1207
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0219 0.1302
Schistosoma mansoni survival motor neuron protein 0.0048 0.0148 0.0172
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0041 0.0108 0.0125
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0009 0.0082
Loa Loa (eye worm) hypothetical protein 0.0054 0.0186 0.0384
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0116 0.0657
Toxoplasma gondii hypothetical protein 0.0046 0.0136 0.0136
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0067 0.0112
Brugia malayi glutathione reductase 0.0037 0.0085 0.0152
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.0067 0.081
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0037 0.0083 0.0148
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0067 0.0062
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0105 0.0489 0.3827
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0128 0.0146
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0116 0.0657
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0764 0.4411 0.5203
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0047 0.0066
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0037 0.0083 0.6032
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0077 0.0423
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0269
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0369 0.4534
Mycobacterium leprae putative cytochrome p450 0.0034 0.0067 0.1547
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0261 0.0553
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0036 0.003
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0716 0.4291
Schistosoma mansoni hypothetical protein 0.0034 0.0067 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.0067 0.081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0045 0.005
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0105 0.0489 0.293
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0228 0.0233
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0077 0.0452
Leishmania major metacaspase, putative 0.0027 0.0021 0.0113
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0159 0.0159
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0047 0.0066
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0652 0.3746 0.3972
Loa Loa (eye worm) hypothetical protein 0.0043 0.0119 0.0231
Echinococcus granulosus geminin 0.0333 0.1843 0.2235
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.0067 0.081
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0046 0.0136 0.0135
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0047 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.012 0.0711
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.1203
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0338 0.4147
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0369 0.8665
Brugia malayi jmjC domain containing protein 0.0041 0.0108 0.0206
Schistosoma mansoni sodium/chloride dependent transporter 0.0046 0.0136 0.0157
Plasmodium falciparum metacaspase-like protein 0.0027 0.0021 0.1406
Schistosoma mansoni jumonji/arid domain-containing protein 0.0155 0.0785 0.0923
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0045 0.005
Trypanosoma brucei unspecified product 0.0037 0.0081 0.0474
Onchocerca volvulus 0.0046 0.0136 0.0584
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0186 0.0189
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0116 0.0657
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0064 0.0068
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0077 0.0083
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0078 0.1564
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.0067 0.081
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.0067 0.081
Leishmania major cytochrome p450-like protein 0.0034 0.0067 0.0394
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0083 0.0457
Echinococcus multilocularis muscleblind protein 0.0154 0.0779 0.0818
Onchocerca volvulus 0.0271 0.1474 0.7372
Loa Loa (eye worm) hypothetical protein 0.0067 0.0261 0.0553
Echinococcus granulosus microtubule associated protein 2 0.1403 0.8216 1
Echinococcus multilocularis aminopeptidase N 0.0358 0.1993 0.2108
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0036 0.0036
Brugia malayi mbt repeat family protein 0.0048 0.0147 0.0294
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0046 0.0136 0.0155
Loa Loa (eye worm) MBCTL1 0.0054 0.0186 0.0384
Schistosoma mansoni hypothetical protein 0.0339 0.188 0.2216
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0136 0.0157
Treponema pallidum sodium- and chloride- dependent transporter 0.0271 0.1474 1
Onchocerca volvulus 0.0048 0.0148 0.0647
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0083 0.0457
Echinococcus granulosus bloom syndrome protein 0.0045 0.0133 0.0152
Loa Loa (eye worm) hypothetical protein 0.0764 0.4411 1
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1267 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.0067 0.081
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0426 0.5232
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.1427
Loa Loa (eye worm) glutathione reductase 0.0037 0.0085 0.0152
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0076 0.0086
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0077 0.0556
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0133 0.1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0077 0.1541
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0007 0.003
Loa Loa (eye worm) hypothetical protein 0.0154 0.0779 0.1732
Schistosoma mansoni hypothetical protein 0.0067 0.0261 0.0304
Echinococcus multilocularis jumonji domain containing 1A 0.0041 0.0108 0.0106
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0077 1
Plasmodium falciparum flap endonuclease 1 0.0026 0.0018 0.1184
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0018 0.0086
Giardia lamblia PHD finger protein 15 0.0029 0.0036 0.0926
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0331 0.1955
Loa Loa (eye worm) hypothetical protein 0.0068 0.0269 0.0572
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0215 0.1144 0.1384
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0136 0.0157
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0067 0.081
Schistosoma mansoni hypothetical protein 0.0029 0.0036 0.004
Onchocerca volvulus Alhambra homolog 0.0029 0.0036 0.0079
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0007 0.0103
Trichomonas vaginalis DNA polymerase eta, putative 0.008 0.0338 0.2626
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0269
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0067 0.0363
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0083 0.009
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.0067 0.081
Brugia malayi jmjC domain containing protein 0.0155 0.0785 0.1746
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0179 0.2188
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.0067 0.081
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.0067 0.081
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0046 0.0136 0.0135
Brugia malayi polk-prov protein 0.0043 0.0119 0.0231
Loa Loa (eye worm) hypothetical protein 0.0764 0.4411 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Brugia malayi DOMON domain containing protein 0.0146 0.0733 0.1628
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.0489 0.0511
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0269
Schistosoma mansoni hypothetical protein 0.0035 0.0071 0.0081
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0018 0.0065
Loa Loa (eye worm) serotonin transporter b 0.0271 0.1474 0.3316
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0271 0.1474 0.1737
Leishmania major DNA polymerase eta, putative 0.0079 0.0331 0.198
Echinococcus granulosus phd:f box containing protein 0.0041 0.0108 0.0122
Brugia malayi Bromodomain containing protein 0.0029 0.0036 0.0042
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0556 0.1226
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0018 0.0326
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0018 0.0018
Brugia malayi cytochrome P450 0.0034 0.0067 0.0113
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0071 0.0081
Loa Loa (eye worm) hypothetical protein 0.0252 0.1366 0.3068
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0359 0.042
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.0067 0.081
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0037 0.0083 0.0094
Mycobacterium tuberculosis Conserved protein 0.0025 0.0009 0.0082
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.0489 0.0586
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0078 0.1564
Brugia malayi hypothetical protein 0.0035 0.0071 0.0122
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0077 0.0556
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.0179 0.0208
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0148
Brugia malayi Pre-SET motif family protein 0.0031 0.0045 0.0062
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.0067 0.081
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.0067 0.081
Loa Loa (eye worm) hypothetical protein 0.0154 0.0779 0.1732
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0228 0.0267
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0171 0.0991
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.1203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0128 0.0127
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0018 0.1184
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0032 0.0029
Brugia malayi TATA binding protein associated factor 0.0037 0.0083 0.0148
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0338 0.1996
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0652 0.3746 0.4554
Brugia malayi jmjC domain containing protein 0.0041 0.0108 0.0206
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.008 0.0338 0.2626
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0078 0.0565
Brugia malayi jmjC domain containing protein 0.0215 0.1144 0.2564
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0078 0.0565
Trypanosoma brucei Aminopeptidase M1, putative 0.0105 0.0489 0.293
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0159 0.032
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0105 0.0102
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0009 0.004
Trypanosoma cruzi metacaspase, putative 0.0027 0.0021 0.0083
Echinococcus multilocularis peregrin 0.0039 0.0093 0.009
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.0067 0.081
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0338 0.202
Brugia malayi Muscleblind-like protein 0.0154 0.0779 0.1732
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.0067 0.081
Loa Loa (eye worm) hypothetical protein 0.0068 0.0269 0.0572
Brugia malayi Thioredoxin reductase 0.0037 0.0085 0.0152
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0007
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0041 0.0108 0.0108
Schistosoma mansoni phd/f-box containing protein 0.0041 0.0108 0.0125
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0078 0.0565
Echinococcus granulosus alkaline phosphatase 0.0652 0.3746 0.4554
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.0067 0.081
Leishmania major trypanothione reductase 0.0037 0.0085 0.0497
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0338 0.1996
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0338 0.202
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0021 0.0083
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0136 0.0157
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0045 0.0039
Mycobacterium ulcerans aminopeptidase N PepN 0.0037 0.0083 0.0998
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0052
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0067 0.0067
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0222 0.0464
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0047 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0369 0.4534
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0219 0.2674
Echinococcus granulosus serotonin transporter 0.0271 0.1474 0.1786
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0067 0.0365
Onchocerca volvulus 0.0105 0.0489 0.2377
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0087 0.0084
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0105 0.0489 0.3827
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0331 0.0713
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.1203
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.1427
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0021 0.0021
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.0489 0.0511
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0159 0.0159
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0068 0.0269 0.158
Onchocerca volvulus 0.0031 0.0045 0.0123
Trypanosoma brucei Aminopeptidase M1, putative 0.0105 0.0489 0.293
Toxoplasma gondii hypothetical protein 0.0049 0.0153 0.0153
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0067 0.4864
Loa Loa (eye worm) DOMON domain-containing protein 0.0146 0.0733 0.1628
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0021 0.011
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0269
Loa Loa (eye worm) hypothetical protein 0.0079 0.0331 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0021 0.011
Brugia malayi DOMON domain containing protein 0.0146 0.0733 0.1628
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0046 0.0136 0.0269
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.0067 0.081
Echinococcus multilocularis GPCR, family 2 0.0031 0.0047 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0119 0.0706
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0078 0.0078
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0046 0.0136 0.0135
Trypanosoma cruzi Aminopeptidase M1, putative 0.0105 0.0489 0.2909
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.0067 0.081
Schistosoma mansoni caspase-3 (C14 family) 0.0027 0.0021 0.0021
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0067 0.0365
Loa Loa (eye worm) jmjC domain-containing protein 0.0155 0.0785 0.1746
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0128 0.0148
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.1665 1
Brugia malayi mbt repeat family protein 0.0048 0.0147 0.0294
Trypanosoma brucei metacaspase MCA3 0.0027 0.0021 0.0113
Schistosoma mansoni inositol monophosphatase 0.0036 0.0077 0.0088
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0009 0.001
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.0067 0.081
Brugia malayi Inositol-1 0.0036 0.0077 0.0135
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0159 0.0914
Echinococcus multilocularis microtubule associated protein 2 0.1403 0.8216 0.8722
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0083 0.0457
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0835 0.0878
Plasmodium falciparum glutathione reductase 0.0037 0.0085 0.6163
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0045 0.005
Schistosoma mansoni phosphatidylserine receptor 0.0041 0.0108 0.0125
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0021 0.0021
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.0179 0.3636
Onchocerca volvulus 0.0037 0.0083 0.0314
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0764 0.4411 1
Loa Loa (eye worm) aminopeptidase N 0.0105 0.0489 0.1073
Echinococcus multilocularis caspase 2 0.0027 0.0021 0.0013
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0067 0.0365
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.0067 0.081
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.0067 0.081
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0018 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0445 0.0973
Echinococcus multilocularis serotonin transporter 0.0271 0.1474 0.1558
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1265 0.1531
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0067 0.4864
Leishmania major hypothetical protein, conserved 0.0034 0.0067 0.0392
Loa Loa (eye worm) hypothetical protein 0.0082 0.0351 0.0757
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0078 0.0565
Echinococcus multilocularis dna polymerase kappa 0.008 0.0338 0.035
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.0067 0.081
Schistosoma mansoni jumonji domain containing protein 0.0041 0.0108 0.0125
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.0067 0.0394
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0021 0.0007
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0037 0.0083 0.0079
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0041 0.0108 0.0122
Brugia malayi Cytochrome P450 family protein 0.0034 0.0067 0.0113
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0046 0.0136 0.0269
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0369 0.4534
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0652 0.3746 0.3972
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0835 0.0878
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0046 0.0136 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0213 0.1132 0.6796
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1098 0.2458
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.012 0.0711
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0147 0.017
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0764 0.4411 1
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0133 0.0132
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0083 0.0148
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0338 0.1996
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0812 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0426 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0007
Echinococcus granulosus sodium and chloride dependent glycine 0.0046 0.0136 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.1203
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0105 0.0489 0.293
Plasmodium falciparum amino acid transporter, putative 0.0046 0.0136 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0041 0.0108 0.064
Schistosoma mansoni DNA polymerase eta 0.0079 0.0331 0.0388
Brugia malayi Peptidase family M1 containing protein 0.0105 0.0489 0.1073
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0835 0.186
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.1665 1
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0179 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0021 0.011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.0179 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0136 0.0136
Mycobacterium tuberculosis Probable reductase 0.0085 0.0369 0.4534
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0067 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0062
Loa Loa (eye worm) DOMON domain-containing protein 0.0146 0.0733 0.1628
Echinococcus granulosus dna polymerase kappa 0.008 0.0338 0.0401
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0835 0.186
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0269
Trypanosoma brucei Metacaspase-4 0.0027 0.0021 0.0113
Entamoeba histolytica aminopeptidase, putative 0.0105 0.0489 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0009 0.0082
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0269
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0556 0.1226
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.0067 0.0394
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0064 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.0067 0.081
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0228 0.1754
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.0067 0.081
Schistosoma mansoni alkaline phosphatase 0.0652 0.3746 0.4418
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0009 0.0082
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.0067 0.081
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0083 0.0602
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0067 0.0394
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0036 0.0036
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0426 0.5232
Trypanosoma brucei metacaspase 0.0027 0.0021 0.0113
Echinococcus granulosus neuropeptide s receptor 0.0566 0.3233 0.3929
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.1132 0.6786
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0136 0.0136
Brugia malayi hypothetical protein 0.0046 0.0136 0.0269
Echinococcus granulosus caspase 8 0.0027 0.0021 0.0015
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0083 0.0486
Schistosoma mansoni SET domain protein 0.0034 0.0064 0.0073
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0007 0.003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0078 0.0137
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0388 0.2171 0.49
Brugia malayi Cytochrome P450 family protein 0.0034 0.0067 0.0113
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0159 0.0159
Echinococcus multilocularis JmjC domain containing protein 4 0.0041 0.0108 0.0106
Loa Loa (eye worm) norepinephrine transporter 0.0271 0.1474 0.3316
Schistosoma mansoni jumonji/arid domain-containing protein 0.0155 0.0785 0.0923
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0077 0.0556
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0083 0.0486
Loa Loa (eye worm) hypothetical protein 0.0083 0.0359 0.0776
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0108 0.0206
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0228 0.0479
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0128 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0299 0.1783
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0071 0.0077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0445 0.0973
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0045 0.005
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0186 0.0384
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0764 0.4411 0.5364
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0067 0.0071
Loa Loa (eye worm) inositol-1 0.0036 0.0077 0.0135
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0078 0.0565
Schistosoma mansoni microtubule-associated protein tau 0.1403 0.8216 0.9694
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0186 0.0217
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0105 0.0489 0.2909
Echinococcus granulosus JmjC domain containing protein 4 0.0041 0.0108 0.0122
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.0489 0.0511
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0133 0.0262
Loa Loa (eye worm) hypothetical protein 0.0271 0.1474 0.3316
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0083 0.6032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0045 0.0045
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.0067 0.081
Onchocerca volvulus 0.0358 0.1993 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0037 0.0083 0.0094
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0021 0.0021
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0085 0.0468
Brugia malayi Cell death protein 3 precursor 0.0027 0.0021 0.0007
Schistosoma mansoni alpha-glucosidase 0.0141 0.07 0.0822
Echinococcus multilocularis alkaline phosphatase 0.0652 0.3746 0.3972
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0046 0.0136 0.0155
Brugia malayi hypothetical protein 0.0236 0.1265 0.2839
Trypanosoma brucei glucosidase, putative 0.0036 0.0078 0.0458
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0652 0.3746 0.3972
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Echinococcus granulosus GPCR family 2 0.0031 0.0047 0.0047
Echinococcus granulosus caspase 2 0.0027 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0271 0.1474 0.3316
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.0067 0.081
Leishmania major DNA polymerase eta, putative 0.0042 0.0113 0.0666
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0041 0.0108 0.0108
Echinococcus multilocularis sodium and chloride dependent glycine 0.0046 0.0136 0.0135
Onchocerca volvulus 0.0146 0.0733 0.3613
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0269
Plasmodium falciparum thioredoxin reductase 0.0037 0.0085 0.6163
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.0067 0.081
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0055 0.1242
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0113 0.0638
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.012 0.0711
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0136 0.0157
Echinococcus multilocularis 0.0034 0.0067 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0187 0.0384
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.0067 0.0365
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0045 0.0045
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0269 0.0277
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.0067 0.081
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0067 0.0365
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0021 0.0021
Leishmania major cytochrome p450-like protein 0.0034 0.0067 0.0394
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.0067 0.081
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.0067 0.081
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0041 0.0108 0.0611
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0136 0.0269
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0147 0.0294
Loa Loa (eye worm) RecQ helicase 0.0045 0.0133 0.0262
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0021 0.0021
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0206
Brugia malayi Augmenter of liver regeneration 0.0034 0.0067 0.0112
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0041 0.0108 0.0611
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.0067 0.0072
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1665 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0046 0.0136 0.0155
Schistosoma mansoni aminopeptidase A (M01 family) 0.0037 0.0083 0.0094
Brugia malayi Peptidase family M1 containing protein 0.0358 0.1993 0.4495
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.1427
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0071 0.0067
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0036 0.0034
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0219 0.1302
Trypanosoma cruzi aminopeptidase, putative 0.0105 0.0489 0.2909
Echinococcus multilocularis lysine specific demethylase 5A 0.0155 0.0785 0.0825
Schistosoma mansoni alpha-glucosidase 0.0141 0.07 0.0822
Echinococcus granulosus lysine specific demethylase 5A 0.0155 0.0785 0.0946
Echinococcus granulosus peregrin 0.0039 0.0093 0.0103
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1265 0.1335
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.0067 0.081
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0052
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0047 0.0047
Echinococcus multilocularis lysine specific demethylase 6a 0.0041 0.0108 0.0106
Mycobacterium ulcerans hypothetical protein 0.0025 0.0009 0.0082
Trypanosoma brucei metacaspase MCA2 0.0027 0.0021 0.0113
Echinococcus multilocularis phd:f box containing protein 0.0041 0.0108 0.0106
Schistosoma mansoni dopamine-beta-monooxygenase 0.1447 0.8475 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0271 0.1474 0.3316
Brugia malayi jmjC domain containing protein 0.0041 0.0108 0.0206
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0021 0.0113
Trypanosoma brucei aminopeptidase, putative 0.0037 0.0083 0.0486
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0077 0.0927
Leishmania major hypothetical protein, conserved 0.0213 0.1132 0.6796
Plasmodium falciparum phd finger protein, putative 0.0029 0.0036 0.257
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0148 0.0297
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0159 0.0942
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.0179 0.0208
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0695 0.4003 0.907
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0119 0.0706
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0338 0.4147
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0186 0.0217
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0021 0.0021
Echinococcus granulosus sodium and chloride dependent glycine 0.0046 0.0136 0.0155
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0067 0.0392
Toxoplasma gondii aminopeptidase N protein 0.0037 0.0083 0.0083
Trypanosoma cruzi metacaspase, putative 0.0027 0.0021 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0021 0.1406
Toxoplasma gondii aminopeptidase N, putative 0.0037 0.0083 0.0083
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0159 0.0183
Schistosoma mansoni hypothetical protein 0.0295 0.1617 0.1905
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.0067 0.081
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0078 0.0429
Brugia malayi follicle stimulating hormone receptor 0.0695 0.4003 0.907
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0077 0.0077
Onchocerca volvulus 0.0048 0.0147 0.0641
Echinococcus granulosus intestinal type alkaline phosphatase 0.0652 0.3746 0.4554
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0716 0.4273
Plasmodium falciparum JmjC domain-containing protein, putative 0.0041 0.0108 0.7939
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0128 0.0148
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0136 0.0136
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0036 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0136 1
Onchocerca volvulus 0.0146 0.0733 0.3613
Leishmania major cytochrome p450-like protein 0.0034 0.0067 0.0394
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.0489 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.0067 0.081
Brugia malayi MH2 domain containing protein 0.0117 0.0556 0.1226
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0159 0.0914
Onchocerca volvulus 0.0083 0.0359 0.1714
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0078 0.0565
Echinococcus granulosus jumonji domain containing 1A 0.0041 0.0108 0.0122
Onchocerca volvulus 0.0094 0.0425 0.2049
Toxoplasma gondii hypothetical protein 0.0046 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0061 0.0228 0.0266
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0009 0.001
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0159 0.7012
Loa Loa (eye worm) hypothetical protein 0.0236 0.1265 0.2839
Loa Loa (eye worm) hypothetical protein 0.0321 0.1772 0.3993
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.1132 0.6786
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0045 0.0039
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.1008 0.1218
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0077 0.0073
Mycobacterium ulcerans hypothetical protein 0.016 0.0812 1
Schistosoma mansoni alkaline phosphatase 0.0652 0.3746 0.4418
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0764 0.4411 0.4679
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0027 0.0021 0.0015
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0779 0.0818
Schistosoma mansoni protein phosphatase 2C 0.0041 0.0108 0.0125
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.0489 0.0586
Echinococcus multilocularis geminin 0.0333 0.1843 0.1949
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0716 0.4291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0128 0.0251
Schistosoma mansoni cytochrome P450 0.0034 0.0067 0.0076
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0018 0.0095
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.0489 0.0511
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.0067 0.081
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0136 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0338 0.202
Giardia lamblia DINP protein human, muc B family 0.006 0.0219 1
Schistosoma mansoni hypothetical protein 0.0333 0.1843 0.2172
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.0179 0.0181
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0136 0.0269
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0108 0.0206
Loa Loa (eye worm) peptidase family M1 containing protein 0.029 0.1586 0.3569
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0036 0.257
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.0067 0.081
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1605 0.9419 1
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.0067 0.1547
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0087 0.0096
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0027 0.0021 0.0013
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0037 0.0083 0.6032
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0338 0.1996
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0078 0.0085
Brugia malayi Pre-SET motif family protein 0.0207 0.1098 0.2458
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0186 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0206
Loa Loa (eye worm) hypothetical protein 0.0098 0.0445 0.0973
Leishmania major hypothetical protein, conserved 0.0041 0.0108 0.064
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0046 0.0136 0.0157
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0159 0.0942
Schistosoma mansoni sodium/chloride dependent transporter 0.0046 0.0139 0.016
Loa Loa (eye worm) hypothetical protein 0.0138 0.0685 0.1519
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0652 0.3746 0.4554
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0078 0.0458
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0047 0.0041
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0159 0.0942
Loa Loa (eye worm) hypothetical protein 0.0048 0.0147 0.0294
Echinococcus multilocularis dna polymerase eta 0.0079 0.0331 0.0343
Entamoeba histolytica hypothetical protein 0.0035 0.0071 0.1427
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.0489 0.0511
Echinococcus granulosus flap endonuclease 1 0.0026 0.0018 0.0011
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0077 0.0452
Leishmania major DNA polymerase kappa, putative 0.006 0.0219 0.1302
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0067 0.0113
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0136 0.0157
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0021 0.011
Echinococcus multilocularis neuropeptide receptor A26 0.0566 0.3233 0.3427
Echinococcus granulosus caspase 0.0027 0.0021 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.0067 0.081
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0186 0.0189
Schistosoma mansoni peptidylglycine monooxygenase 0.0764 0.4411 0.5203
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.0067 0.081
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0147 0.0147

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) = 0.34 uM Inhibition of cell growth was determined in DU145 cell line of human prostate tumor using MTT assay, on day 6 after treatment ChEMBL. 11462980
ID50 (functional) = 0.54 uM Inhibition of cell growth was determined in LNCaP cell line of human prostate tumor using MTT assay, on day 6 after treatment ChEMBL. 11462980
ID50 (functional) > 31.25 uM Inhibition of cell growth was determined in DUPRO cell line of human prostate tumor using MTT assay, on day 6 after treatment ChEMBL. 11462980
ID50 (functional) > 31.25 uM Inhibition of cell growth was determined in PC-3 cell line of human prostate tumor using MTT assay, on day 6 after treatment ChEMBL. 11462980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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