Detailed information for compound 993664

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.904 | Formula: C18H23ClN2O4S
  • H donors: 3 H acceptors: 3 LogP: 2.4 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](COc1ccc(cc1)NS(=O)(=O)C)CNCCc1ccccc1Cl
  • InChi: 1S/C18H23ClN2O4S/c1-26(23,24)21-15-6-8-17(9-7-15)25-13-16(22)12-20-11-10-14-4-2-3-5-18(14)19/h2-9,16,20-22H,10-13H2,1H3/t16-/m0/s1
  • InChiKey: MGRXMFUTVSKTHL-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster NMDA receptor 2 Glutamate (NMDA) receptor subunit zeta 1   938 aa 878 aa 27.4 %
Drosophila melanogaster Glutamate receptor IA Glutamate (NMDA) receptor subunit zeta 1   938 aa 979 aa 23.7 %
Echinococcus multilocularis glutamate (NMDA) receptor subunit Glutamate (NMDA) receptor subunit zeta 1   938 aa 822 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0057 0.0034 0.0042
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0673 0.0642 0.0642
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0007 0.0006
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0007 0.0008
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Onchocerca volvulus Putative cubilin 0.0045 0.0022 0.0313
Onchocerca volvulus 0.0029 0.0007 0.0097
Onchocerca volvulus 0.0029 0.0007 0.0097
Echinococcus granulosus orexin receptor type 2 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0023 0.0001 0.002
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.0013 0.0282
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0007 0.0008
Loa Loa (eye worm) TK/ROR protein kinase 0.0031 0.0008 0.0008
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0014 0.0144
Onchocerca volvulus 0.0029 0.0007 0.0097
Entamoeba histolytica SWIRM domain protein 0.0057 0.0034 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0034 0.0051
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0007 0.0008
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0472 0.0444 0.6535
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0007 0.0006
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0014 0.0014
Schistosoma mansoni site-1 peptidase (S08 family) 0.0447 0.0419 0.0418
Brugia malayi hypothetical protein 0.0023 0.0001 0.0001
Brugia malayi Serpin protein 6 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0023 0.0001 0.0011
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0035 0.0012 0.0169
Brugia malayi hypothetical protein 0.0036 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0007 0.0008
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Brugia malayi proprotein convertase 2 0.641 0.631 0.631
Onchocerca volvulus 0.0026 0.0003 0.0046
Toxoplasma gondii aspartyl protease ASP5 0.0378 0.0351 0.8386
Onchocerca volvulus 0.0029 0.0007 0.0097
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0007 0.0006
Trichomonas vaginalis WD repeat domain, putative 0.0213 0.0188 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Echinococcus multilocularis serine:threonine protein kinase N2 0.0085 0.0062 0.0076
Brugia malayi celfurPC protein 0.8124 0.8003 0.8003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Brugia malayi hypothetical protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0082 0.0058 0.0058
Toxoplasma gondii PA14 domain-containing protein 0.0043 0.0021 0.0476
Brugia malayi hypothetical protein 0.0036 0.0013 0.0013
Echinococcus multilocularis fibrillin 2 0.0049 0.0026 0.0032
Giardia lamblia Neurogenic locus Notch protein precursor 0.0049 0.0026 0.0069
Loa Loa (eye worm) hypothetical protein 0.0049 0.0026 0.0026
Echinococcus multilocularis 0.0137 0.0113 0.014
Echinococcus granulosus integrin alpha ps 0.0032 0.0009 0.0008
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0073 0.005 0.0049
Brugia malayi Protein kinase domain containing protein 0.0043 0.0021 0.0021
Echinococcus multilocularis protoporphyrinogen oxidase 0.0137 0.0113 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) transcriptional regulator 0.0104 0.008 0.008
Onchocerca volvulus 0.0026 0.0003 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Echinococcus granulosus fibrillin 1 0.0051 0.0029 0.0028
Onchocerca volvulus 0.0029 0.0007 0.0097
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0035 0.0012 0.0011
Brugia malayi neuropeptide F receptor 0.0029 0.0007 0.0007
Plasmodium vivax plasmepsin V, putative 0.0415 0.0388 0.9244
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0021 0.0301
Brugia malayi EGF-like domain containing protein 0.0049 0.0026 0.0026
Brugia malayi hypothetical protein 0.0286 0.026 0.026
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0007 0.0006
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0026 0.0003 0.0003
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0023 0.0001 0.5
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0009 0.0011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0704 0.0674 0.1099
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0007 0.0008
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0014 0.0014
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0021 0.0301
Plasmodium falciparum subtilisin-like protease 2 0.0447 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Onchocerca volvulus 0.0029 0.0007 0.0097
Schistosoma mansoni tyrosine kinase 0.0656 0.0626 0.0625
Schistosoma mansoni hypothetical protein 0.0029 0.0007 0.0006
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0021 0.0029
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Plasmodium falciparum plasmepsin IV 0.0037 0.0014 0.0144
Toxoplasma gondii histone deacetylase SIR2-like 0.0104 0.008 0.1905
Brugia malayi ORL1-like opioid receptor 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0057 0.0034 0.0034
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0007 0.0008
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0026 0.0026
Brugia malayi RE15519p 0.0029 0.0007 0.0007
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0007 0.0008
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0137 0.0113 0.2546
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Onchocerca volvulus 0.0036 0.0013 0.0189
Onchocerca volvulus 0.0026 0.0003 0.0046
Schistosoma mansoni integrin beta subunit 0.1097 0.1062 0.1061
Loa Loa (eye worm) hypothetical protein 1.0145 1 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0673 0.0642 0.0642
Toxoplasma gondii hypothetical protein 0.0049 0.0026 0.0606
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0007 0.0006
Plasmodium falciparum plasmepsin VI 0.0037 0.0014 0.0144
Echinococcus multilocularis growth factor receptor bound protein 2 0.0253 0.0228 0.0284
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Toxoplasma gondii bicoid-interacting protein BIN3 0.0035 0.0012 0.0272
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0104 0.008 0.1084
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Echinococcus granulosus c-Jun N-terminal kinases 0.0226 0.0201 0.02
Schistosoma mansoni integrin alpha-ps 0.0066 0.0043 0.0042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.3942 0.3872 0.3872
Onchocerca volvulus 0.0036 0.0013 0.0189
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.0013 0.0306
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0007 0.0008
Schistosoma mansoni myosin xvIII 0.0029 0.0007 0.0006
Echinococcus multilocularis epidermal growth factor receptor 0.0656 0.0626 0.0781
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0001 0.0001
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0007 0.0006
Schistosoma mansoni biogenic amine receptor 0.0029 0.0007 0.0006
Brugia malayi SWIRM domain containing protein 0.0057 0.0034 0.0034
Loa Loa (eye worm) sirtuin 4 0.0104 0.008 0.008
Schistosoma mansoni neuropeptide receptor 0.0029 0.0007 0.0006
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0002 0.0037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0007 0.0006
Plasmodium vivax aspartyl protease, putative 0.0037 0.0014 0.0144
Trypanosoma cruzi subtilisin peptidase 0.0447 0.0419 0.6173
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0007 0.0008
Onchocerca volvulus 0.0042 0.0019 0.0274
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0088 0.0088
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0026 0.0003 0.0003
Giardia lamblia Tenascin-37 0.0049 0.0026 0.0069
Mycobacterium ulcerans oxidoreductase 0.0137 0.0113 0.2685
Plasmodium vivax subtilisin-like protease 2, putative 0.0447 0.0419 1
Schistosoma mansoni hypothetical protein 0.007 0.0047 0.0046
Brugia malayi larval opioid receptor 0.0029 0.0007 0.0007
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0043 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Brugia malayi GnHR receptor homolog 0.0029 0.0007 0.0007
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0026 0.0004 0.0004
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0007 0.0006
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0447 0.0419 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0002
Giardia lamblia hypothetical protein 0.0057 0.0034 0.0091
Echinococcus granulosus allatostatin A receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Schistosoma mansoni chromatin regulatory protein sir2 0.0104 0.008 0.008
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0052 0.0029 0.0029
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0007 0.0007
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0104 0.008 0.01
Brugia malayi Protein kinase domain containing protein 0.0031 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2468 0.2416 0.3954
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0137 0.0113 0.2685
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0096 0.0073 0.0922
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.6202 0.6105 0.7628
Echinococcus multilocularis adam 0.0108 0.0084 0.0105
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0043 0.0021 0.0025
Echinococcus granulosus discoidin domain receptor 0.0043 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0014
Echinococcus granulosus furin 1.0145 1 1
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0007 0.0006
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.025 0.0225 0.0224
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Onchocerca volvulus 0.0023 0.0001 0.0011
Loa Loa (eye worm) transcriptional regulator 0.0704 0.0674 0.0674
Brugia malayi Sex muscle abnormal protein 5 0.0253 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0002
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0014 0.0014
Echinococcus granulosus nmda type glutamate receptor 0.0127 0.0103 0.0103
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0007 0.0008
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0039 0.0038
Echinococcus granulosus adam 0.0108 0.0084 0.0084
Schistosoma mansoni neuropeptide receptor 0.0029 0.0007 0.0006
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0021
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0447 0.0419 1
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0021 0.0476
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0026 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Schistosoma mansoni growth factor receptor-bound protein 0.0253 0.0228 0.0227
Echinococcus granulosus integrin beta 2 0.1383 0.1344 0.1344
Echinococcus multilocularis CUB 0.0026 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Brugia malayi amine oxidase, flavin-containing family protein 0.0194 0.0169 0.0169
Echinococcus granulosus cubilin 0.0026 0.0003 0.0002
Echinococcus multilocularis membrane bound transcription factor site 1 0.0447 0.0419 0.0523
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0007 0.0008
Giardia lamblia Neurogenic locus notch-like protein 0.0049 0.0026 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0137 0.0113 0.2546
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0021 0.0025
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0007 0.0007
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0007 0.0006
Toxoplasma gondii kringle domain-containing protein 0.0031 0.0008 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Echinococcus multilocularis protein will die slowly 0.0213 0.0188 0.0234
Echinococcus granulosus growth factor receptor bound protein 2 0.0253 0.0228 0.0227
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Brugia malayi transcriptional regulator, Sir2 family protein 0.0104 0.008 0.008
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0007 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0007 0.0008
Plasmodium falciparum protoporphyrinogen oxidase 0.0137 0.0113 0.2546
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0007 0.0008
Brugia malayi EGF-like domain containing protein 0.0049 0.0026 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Echinococcus multilocularis tissue type plasminogen activator 0.0031 0.0008 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.007 0.0069
Schistosoma mansoni hypothetical protein 0.0035 0.0012 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0226 0.0201 0.02
Echinococcus granulosus neuropeptide receptor 0.0029 0.0007 0.0006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0007 0.0006
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0137 0.0113 0.2546
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0007 0.0006
Brugia malayi serpin 0.0023 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0007 0.0006
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0021 0.0021
Schistosoma mansoni furin-1 (S08 family) 0.4389 0.4314 0.4313
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0447 0.0419 0.0419
Brugia malayi serpin 0.0023 0.0001 0.0001
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0022 0.0022
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0104 0.008 0.192
Schistosoma mansoni hypothetical protein 0.0043 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Echinococcus multilocularis chromatin regulatory protein sir2 0.0704 0.0674 0.0841
Brugia malayi EGF-like domain containing protein 0.0049 0.0026 0.0026
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0004 0.0004
Plasmodium falciparum apical sushi protein 0.0036 0.0013 0.0119
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0023 0.0001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0447 0.0419 0.0681
Brugia malayi Protein arginine N-methyltransferase 0.0035 0.0012 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0007 0.0008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0002 0.0025
Schistosoma mansoni septate junction protein 0.0062 0.0039 0.0039
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0704 0.0674 0.1099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6202 0.6105 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0088 0.0088
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.0007 0.0097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0026 0.0003 0.0003
Brugia malayi putative neuropeptide receptor 0.0029 0.0007 0.0007
Brugia malayi hypothetical protein 0.0096 0.0073 0.0073
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0021 0.0476
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0035 0.0012 0.0057
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0447 0.0419 0.0418
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2468 0.2416 0.2415
Echinococcus granulosus neuroendocrine convertase 2 0.641 0.631 0.631
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0704 0.0674 0.0673
Brugia malayi hypothetical protein 0.007 0.0047 0.0047
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.2021 0.1975 0.3231
Loa Loa (eye worm) hypothetical protein 0.007 0.0047 0.0047
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0014 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0034 0.0051
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0014 0.0323
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0039 0.0058
Echinococcus granulosus cubilin 0.0026 0.0003 0.0002
Onchocerca volvulus Fatty acid synthase homolog 0.0043 0.0021 0.0295
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0137 0.0113 0.2667
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0007 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0007 0.0006
Schistosoma mansoni neuropeptide receptor 0.0029 0.0007 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0007 0.0006
Brugia malayi GCC2 and GCC3 family protein 0.0055 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0035 0.0012 0.0057
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.6202 0.6105 0.6105
Schistosoma mansoni discoidin domain receptor 0.0043 0.0021 0.002
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0104 0.008 0.008
Giardia lamblia Tenascin-like 0.0049 0.0026 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Echinococcus granulosus protein arginine N methyltransferase 7 0.0035 0.0012 0.0011
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0014 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Echinococcus granulosus integrin alpha 3 0.0113 0.009 0.0089
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0007 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Brugia malayi Will die slowly protein 0.0213 0.0188 0.0188
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0007 0.0007
Brugia malayi hypothetical protein 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0213 0.0188 0.0188
Echinococcus granulosus sex peptide receptor 0.0029 0.0007 0.0006
Brugia malayi serpin 0.0023 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0057 0.0034 0.0495
Mycobacterium tuberculosis Conserved hypothetical protein 0.0137 0.0113 0.2694
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0026 0.0003 0.0003
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0096 0.0073 0.0974
Onchocerca volvulus 0.0036 0.0013 0.0189
Loa Loa (eye worm) hypothetical protein 0.0045 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0447 0.0419 0.0681
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0021 0.002
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0049 0.0026 0.0038
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0021 0.0476
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0007 0.0007
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0007 0.0008
Onchocerca volvulus 0.0029 0.0007 0.0097
Onchocerca volvulus Arrow homolog 0.0026 0.0004 0.0051
Toxoplasma gondii subtilisin SUB2 0.0447 0.0419 1
Echinococcus granulosus C type lectin domian containing protein 0.0036 0.0013 0.0012
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Plasmodium falciparum subtilisin-like protease 3 0.0447 0.0419 1
Echinococcus granulosus epidermal growth factor receptor 0.0656 0.0626 0.0625
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.0013 0.0318
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) CUB domain-containing protein 0.0026 0.0003 0.0003
Onchocerca volvulus 0.0029 0.0007 0.0097
Echinococcus granulosus nmda type glutamate receptor 0.01 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.0203 0.0203
Brugia malayi Nematode astacin protease protein 30 0.0026 0.0003 0.0003
Giardia lamblia Transcriptional regulator, Sir2 family 0.0104 0.008 0.0217
Brugia malayi Reprolysin 0.0026 0.0004 0.0004
Brugia malayi serpin (BmSERPIN) 0.0023 0.0001 0.0001
Plasmodium vivax subtilisin-like protease 1 0.0447 0.0419 1
Brugia malayi astacin protease protein 30 0.0026 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Echinococcus multilocularis Furin 1 0.2468 0.2416 0.3018
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0007 0.0007
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0002 0.0025
Loa Loa (eye worm) proprotein convertase 2 0.2468 0.2416 0.2416
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0096 0.0073 0.0974
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0036 0.0035
Echinococcus granulosus fibrillin 2 0.0049 0.0026 0.0025
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0447 0.0419 0.0419
Schistosoma mansoni amine GPCR 0.0029 0.0007 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Brugia malayi Melatonin receptor type 1A 0.0029 0.0007 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Trypanosoma brucei subtilisin peptidase 0.0447 0.0419 0.6151
Mycobacterium tuberculosis Possible oxidoreductase 0.0137 0.0113 0.2694
Loa Loa (eye worm) WD40 repeat protein 0.0213 0.0188 0.0188
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0704 0.0674 1
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Onchocerca volvulus 0.007 0.0047 0.0674
Brugia malayi Subtilase family protein 0.0447 0.0419 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Leishmania major arginine N-methyltransferase, type I 0.0035 0.0012 0.0057
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0014 0.0323
Echinococcus multilocularis laminin 0.0026 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0096 0.0073 0.1075
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.0053 0.0775
Leishmania major UDP-galactopyranose mutase 0.0137 0.0113 0.1572
Echinococcus granulosus g protein coupled receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0036 0.0013 0.0013
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0007 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Giardia lamblia Sirtuin type 2 0.0104 0.008 0.0217
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0447 0.0419 0.6173
Trypanosoma brucei SIR2-like protein 4, putative 0.0104 0.008 0.1033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0104 0.008 0.008
Brugia malayi protein kinase C II. 0.0093 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0007 0.0007
Giardia lamblia Tenascin precursor 0.0049 0.0026 0.0069
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Trypanosoma cruzi UDP-galactopyranose mutase 0.0137 0.0113 0.1572
Plasmodium falciparum plasmepsin II 0.0037 0.0014 0.0144
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Echinococcus multilocularis cubilin 0.0026 0.0003 0.0003
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0035 0.0012 0.0272
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Onchocerca volvulus 0.0037 0.0014 0.0204
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0007 0.0008
Trichomonas vaginalis hypothetical protein 0.0043 0.0021 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0021 0.0021
Brugia malayi Kringle domain containing protein 0.0031 0.0008 0.0008
Loa Loa (eye worm) Carm1-pending protein 0.0035 0.0012 0.0012
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0137 0.0113 0.2546
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0704 0.0674 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0137 0.0113 0.0112
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0007 0.0006
Brugia malayi CUB domain containing protein 0.0026 0.0003 0.0003
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0003 0.006
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0194 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Loa Loa (eye worm) hypothetical protein 0.0116 0.0092 0.0092
Brugia malayi ADAMTS-like protease 0.0026 0.0004 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0007 0.0006
Echinococcus multilocularis fibrillin 1 0.0077 0.0054 0.0067
Loa Loa (eye worm) subtilase 0.0447 0.0419 0.0419
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0007 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0007 0.0006
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0035 0.0012 0.0014
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0035 0.0012 0.0014
Schistosoma mansoni protein arginine n-methyltransferase 0.0035 0.0012 0.0011
Onchocerca volvulus 0.0029 0.0007 0.0097
Onchocerca volvulus 0.0036 0.0013 0.0189
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0104 0.008 0.01
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0472 0.0444 0.6555
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0043 0.0021 0.0025
Echinococcus granulosus protein arginine N methyltransferase 8 0.0062 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Schistosoma mansoni btb and poz domain-containing protein 0.0043 0.0021 0.002
Brugia malayi hypothetical protein 0.0037 0.0014 0.0014
Brugia malayi serpin 0.0023 0.0001 0.0001
Brugia malayi Dopamine receptor 0.0029 0.0007 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0007 0.0008
Onchocerca volvulus 0.0043 0.0021 0.0296
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Brugia malayi hypothetical protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) reprolysin 0.0045 0.0022 0.0022
Onchocerca volvulus 0.0029 0.0007 0.0097
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0007 0.0007
Brugia malayi CUB domain containing protein 0.0026 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Toxoplasma gondii subtilisin SUB8 0.0447 0.0419 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Brugia malayi serpin (BmSERPIN) 0.0023 0.0001 0.0001
Schistosoma mansoni discoidin domain receptor 0.0043 0.0021 0.002
Echinococcus multilocularis protein arginine methyltransferase 0.0062 0.0039 0.0047
Echinococcus granulosus methyltransferase protein 5 0.0035 0.0012 0.0011
Echinococcus granulosus hypothetical protein 0.0029 0.0007 0.0006
Brugia malayi AKH receptor 0.0029 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0447 0.0419 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0447 0.0419 0.0681
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Schistosoma mansoni biogenic amine receptor 0.0029 0.0007 0.0006
Toxoplasma gondii subtilisin SUB6 0.0447 0.0419 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0447 0.0419 0.0418
Schistosoma mansoni integrin alpha-ps 0.0034 0.0012 0.0011
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0022 0.0022
Brugia malayi Fibulin-1 precursor 0.0026 0.0004 0.0004
Toxoplasma gondii subtilisin SUB7 0.0447 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Brugia malayi serpin 0.0023 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Brugia malayi BmSERPIN 0.0023 0.0001 0.0001
Brugia malayi Carm1-pending protein 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0014 0.0014
Brugia malayi Serotonin receptor 0.0029 0.0007 0.0007
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0253 0.0228 0.0228
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Schistosoma mansoni opsin-like receptor 0.0029 0.0007 0.0006
Schistosoma mansoni SWI/SNF complex-related 0.0057 0.0034 0.0033
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.007 0.0047 0.0046
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.0013 0.0318
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Onchocerca volvulus 0.0026 0.0003 0.0046
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0007 0.0007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.0029 0.0007 0.0006
Onchocerca volvulus 0.0037 0.0014 0.0204
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0004 0.0067
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0007 0.0006
Onchocerca volvulus 0.0029 0.0007 0.0097
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.0145 1 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0104 0.008 0.01
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0007 0.0008
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0021 0.0301
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0007 0.0006
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.2021 0.1975 0.3231
Brugia malayi Sushi domain 0.0036 0.0013 0.0013
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0035 0.0012 0.0057
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0018
Echinococcus granulosus protein will die slowly 0.0213 0.0188 0.0188
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0012 0.0015
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0039 0.0058
Onchocerca volvulus 0.0036 0.0013 0.0189
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2468 0.2416 0.3954
Brugia malayi ADAM-TS Spacer 1 family protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Loa Loa (eye worm) transcriptional regulator 0.0104 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0673 0.0642 0.0642
Schistosoma mansoni hypothetical protein 0.2021 0.1975 0.1974
Echinococcus granulosus serotonin receptor 0.0029 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0007 0.0008
Echinococcus multilocularis protein jagged 2 0.0049 0.0026 0.0032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0023 0.0001 0.0011
Schistosoma mansoni opsin-like receptor 0.0029 0.0007 0.0006
Mycobacterium ulcerans monoamine oxidase 0.0137 0.0113 0.2685
Leishmania major subtilisin-like serine peptidase 0.0447 0.0419 0.6173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2468 0.2416 0.3954
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0007 0.0007
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0026 0.0003 0.0002
Echinococcus multilocularis integrin alpha ps 0.0032 0.0009 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Onchocerca volvulus 0.0029 0.0007 0.0097
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0043 0.0021 0.0458
Brugia malayi Dopamine receptor protein 2 0.0029 0.0007 0.0007
Toxoplasma gondii subtilisin SUB11 0.0447 0.0419 1
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0014 0.0323
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0447 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Brugia malayi pregnancy-associated plasma protein-A 0.0036 0.0013 0.0013
Schistosoma mansoni histamine h1 receptor 0.0029 0.0007 0.0006
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.0076 0.0095
Toxoplasma gondii subtilisin SUB4 0.0447 0.0419 1
Brugia malayi Calcium binding EGF domain containing protein 0.0045 0.0022 0.0022
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0007 0.0007
Brugia malayi G protein-coupled receptor 0.0029 0.0007 0.0007
Onchocerca volvulus 0.0036 0.0013 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0007 0.0006
Schistosoma mansoni adenoreceptor 0.0029 0.0007 0.0006
Mycobacterium ulcerans dehydrogenase 0.0137 0.0113 0.2685
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0007 0.0006
Echinococcus multilocularis C type lectin domian containing protein 0.0036 0.0013 0.0016
Echinococcus granulosus glutamate receptor NMDA 0.0095 0.0072 0.0071
Brugia malayi Serotonin receptor 0.0029 0.0007 0.0007
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0003 0.0035
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Brugia malayi CUB domain containing protein 0.0026 0.0003 0.0003
Loa Loa (eye worm) serpin 0.0023 0.0001 0.0001
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0062 0.0039 0.0047
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0026 0.0026
Toxoplasma gondii subtilisin SUB12 0.0447 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Onchocerca volvulus 0.0029 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Chlamydia trachomatis protoporphyrinogen oxidase 0.0137 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Plasmodium vivax aspartyl protease, putative 0.0037 0.0014 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0014
Onchocerca volvulus 0.0023 0.0001 0.0011
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0062 0.0039 0.0741
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0447 0.0419 0.0418
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0026 0.0003 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2468 0.2416 0.3954
Brugia malayi transcriptional regulator, Sir2 family protein 0.0104 0.008 0.008
Loa Loa (eye worm) DPY-31 protein 0.0026 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0472 0.0444 0.6555
Brugia malayi hypothetical protein 0.0059 0.0036 0.0036
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Echinococcus granulosus integrin alpha ps 0.0066 0.0043 0.0042
Schistosoma mansoni biogenic amine receptor 0.0029 0.0007 0.0006
Brugia malayi hypothetical protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0312 0.0286 0.0286
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0007 0.0006
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.007 0.0047 0.0047
Echinococcus multilocularis MAM 0.007 0.0047 0.0058
Echinococcus granulosus g protein coupled receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) TK/EGFR protein kinase 0.0656 0.0626 0.0626
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0447 0.0419 0.0681
Leishmania major silent information regulator 2, putative 0.0704 0.0674 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0026 0.0026
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0104 0.008 0.1756
Brugia malayi Probable ATP-dependent helicase DHX35 0.0034 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Giardia lamblia hypothetical protein 0.0049 0.0026 0.0069
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Echinococcus multilocularis 0.8124 0.8003 1
Echinococcus multilocularis nmda type glutamate receptor 0.0127 0.0103 0.0128
Echinococcus multilocularis serotonin receptor 0.0029 0.0007 0.0008
Brugia malayi Lectin C-type domain containing protein 0.0026 0.0003 0.0003
Echinococcus granulosus c4b binding protein beta chain 0.0036 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0021
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0007 0.0006
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0026 0.0003 0.0003
Trichomonas vaginalis hypothetical protein 0.0049 0.0026 0.0038
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0026 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0057 0.0034 0.0033
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0447 0.0419 1
Onchocerca volvulus 0.0029 0.0007 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0137 0.0113 0.2546
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Loa Loa (eye worm) CUB domain-containing protein 0.0026 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0002
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0014 0.0014
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0022 0.0027
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0447 0.0419 1
Loa Loa (eye worm) serpin 0.0023 0.0001 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0007 0.0006
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0035 0.0012 0.0272
Brugia malayi EGF-like domain containing protein 0.0049 0.0026 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0007 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6202 0.6105 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0113 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0104 0.008 0.1756
Schistosoma mansoni amine GPCR 0.0029 0.0007 0.0006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0007 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0007 0.0008
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0003 0.006
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0002 0.0037
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0014 0.0014
Brugia malayi G-protein coupled receptor 0.0029 0.0007 0.0007
Schistosoma mansoni chromatin regulatory protein sir2 0.0704 0.0674 0.0673
Loa Loa (eye worm) hypothetical protein 0.0045 0.0022 0.0022
Plasmodium falciparum plasmepsin I 0.0037 0.0014 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0007 0.0008
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0104 0.008 0.008
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0004 0.0067
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0137 0.0113 0.2685
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0007 0.0006
Trypanosoma cruzi UDP-galactopyranose mutase 0.0137 0.0113 0.1572
Giardia lamblia Furin precursor putative serine protease 0.2021 0.1975 0.5383
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0021 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Echinococcus multilocularis discoidin domain receptor 0.0043 0.0021 0.0025
Schistosoma mansoni amine oxidase 0.0137 0.0113 0.0112
Onchocerca volvulus 0.0036 0.0013 0.0189
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0022 0.0022
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0093 0.007 0.007
Toxoplasma gondii subtilisin SUB9 0.0447 0.0419 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Echinococcus multilocularis sex peptide receptor 0.0029 0.0007 0.0008
Brugia malayi G-protein coupled receptor 0.0029 0.0007 0.0007
Entamoeba histolytica SWIRM domain protein 0.0057 0.0034 0.0495
Onchocerca volvulus 0.0447 0.0419 0.5997
Echinococcus granulosus lysine specific histone demethylase 1A 0.0137 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0023 0.0001 0.5
Onchocerca volvulus 0.0023 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Giardia lamblia High cysteine protein 0.0049 0.0026 0.0069
Echinococcus granulosus Tolloid protein 1 0.0052 0.0029 0.0028
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0014 0.0323
Echinococcus multilocularis protein kinase c epsilon type 0.0093 0.007 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0007 0.0008
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0007 0.0006
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0007 0.0006
Brugia malayi SWIRM domain containing protein 0.073 0.0699 0.0699
Schistosoma mansoni chromatin regulatory protein sir2 0.0704 0.0674 0.0673
Brugia malayi hypothetical protein 0.0023 0.0001 0.0001
Echinococcus multilocularis c4b binding protein beta chain 0.0036 0.0013 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0096 0.0073 0.0073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0447 0.0419 1
Schistosoma mansoni amine GPCR 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0646 0.0616 0.0616
Onchocerca volvulus 0.004 0.0017 0.0243
Mycobacterium ulcerans Sir2-like regulatory protein 0.0104 0.008 0.191
Brugia malayi angiogenesis inhibito 0.0026 0.0004 0.0004
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0096 0.0073 0.1075
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2468 0.2416 0.3954
Echinococcus granulosus laminin 0.0026 0.0004 0.0003
Schistosoma mansoni amine oxidase 0.0137 0.0113 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Schistosoma mansoni opsin-like receptor 0.0029 0.0007 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Mycobacterium leprae Possible secreted protease 0.0447 0.0419 1
Schistosoma mansoni hypothetical protein 0.0031 0.0008 0.0008
Brugia malayi Nematode astacin protease protein 30 0.0026 0.0003 0.0003
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0021 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0007 0.0008
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0007 0.0007
Plasmodium falciparum plasmepsin X 0.0037 0.0014 0.0144
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0007 0.0008
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Schistosoma mansoni glutamate receptor NMDA 0.0109 0.0085 0.0085
Schistosoma mansoni integrin alpha 0.0148 0.0124 0.0123
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Echinococcus granulosus chromatin regulatory protein sir2 0.0704 0.0674 0.0673
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0014 0.0014
Schistosoma mansoni site-1 peptidase (S08 family) 0.0447 0.0419 0.0418
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0012 0.0015
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0007 0.0006
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0014 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Brugia malayi hypothetical protein 0.0036 0.0013 0.0013
Schistosoma mansoni amine GPCR 0.0029 0.0007 0.0006
Plasmodium vivax subtilisin-like serine protease, putative 0.0447 0.0419 1
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0021 0.002
Onchocerca volvulus 0.0043 0.0021 0.0296
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0021 0.0029
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0035 0.0012 0.0057
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0673 0.0642 0.0802
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Mycobacterium ulcerans NAD-dependent deacetylase 0.0104 0.008 0.191
Brugia malayi CUB domain containing protein 0.0026 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0007 0.0008
Onchocerca volvulus 0.0036 0.0013 0.0189
Echinococcus granulosus lysine specific histone demethylase 1A 0.0673 0.0642 0.0642
Brugia malayi hypothetical protein 0.0036 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0026 0.0003 0.0002
Brugia malayi hypothetical protein 0.0137 0.0113 0.0113
Trichomonas vaginalis hypothetical protein 0.2021 0.1975 0.3231
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0104 0.008 0.1084
Toxoplasma gondii histone lysine-specific demethylase 0.0137 0.0113 0.2681
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0032 0.0032
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0104 0.008 0.1033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Echinococcus multilocularis integrin beta 2 0.1383 0.1344 0.1679
Brugia malayi neuroendocrine convertase 1 precursor 0.641 0.631 0.631
Loa Loa (eye worm) endoprotease bli-4 1.0145 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0007 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Loa Loa (eye worm) integrin beta-2 0.1871 0.1826 0.1826
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0704 0.0674 1
Brugia malayi serpin precursor 0.0023 0.0001 0.0001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0007 0.0006
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0137 0.0113 0.2685
Echinococcus granulosus protein arginine methyltransferase 0.0062 0.0039 0.0038
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Schistosoma mansoni chromatin regulatory protein sir2 0.0704 0.0674 0.0673
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0014 0.0014
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Onchocerca volvulus 0.0029 0.0007 0.0097
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0447 0.0419 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0007 0.0008
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0014 0.0014
Toxoplasma gondii rhoptry neck protein RON9 0.0036 0.0013 0.0298
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0023 0.0001 0.002
Brugia malayi serpin 0.0023 0.0001 0.0001
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0039 0.0038
Echinococcus multilocularis cubilin 0.0026 0.0003 0.0003
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0052 0.0029 0.0028
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0447 0.0419 0.0523
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0043 0.0021 0.002
Schistosoma mansoni chromatin regulatory protein sir2 0.0104 0.008 0.008
Loa Loa (eye worm) serpin protein 6 0.0023 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0003 0.0054
Onchocerca volvulus 0.0023 0.0001 0.0011
Echinococcus granulosus membrane bound transcription factor site 1 0.0447 0.0419 0.0418
Onchocerca volvulus 0.0031 0.0008 0.0119
Toxoplasma gondii SWIRM domain-containing protein 0.0057 0.0034 0.0795
Echinococcus granulosus Furin 1 0.2468 0.2416 0.2415
Leishmania major arginine N-methyltransferase-like protein 0.0062 0.0039 0.0458
Giardia lamblia Hypothetical protein 0.0704 0.0674 0.1835
Schistosoma mansoni amine GPCR 0.0029 0.0007 0.0006
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0007 0.0008
Schistosoma mansoni neuropeptide receptor 0.0029 0.0007 0.0006
Plasmodium falciparum subtilisin-like protease 1 0.0447 0.0419 1
Loa Loa (eye worm) DEAH box polypeptide 35 0.0034 0.0012 0.0012
Brugia malayi neuropeptide F receptor 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Giardia lamblia Tenascin-X 0.0049 0.0026 0.0069
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0007 0.0006
Onchocerca volvulus 0.007 0.0047 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0017
Toxoplasma gondii subtilisin SUB1 0.0447 0.0419 1
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0704 0.0674 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Mycobacterium ulcerans polyketide synthase 0.0026 0.0003 0.006
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0007 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0007 0.0008
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0104 0.008 0.008
Loa Loa (eye worm) serpin 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0036 0.0013 0.0189
Schistosoma mansoni hypothetical protein 0.0029 0.0007 0.0006
Brugia malayi Integrin beta pat-3 precursor 0.1871 0.1826 0.1826
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0007 0.0008
Echinococcus multilocularis neuroendocrine convertase 2 0.641 0.631 0.7884
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0029 0.0029
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0003 0.0072
Plasmodium vivax aspartyl protease, putative 0.0037 0.0014 0.0144
Echinococcus multilocularis Tolloid protein 1 0.0052 0.0029 0.0035
Echinococcus granulosus CUB 0.0026 0.0003 0.0002
Echinococcus multilocularis integrin alpha ps 0.0066 0.0043 0.0053
Toxoplasma gondii subtilisin SUB10 0.0447 0.0419 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0447 0.0419 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1375 0.1336 0.1336
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0007 0.0006
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0039 0.0038
Schistosoma mansoni hypothetical protein 0.0032 0.0009 0.0008
Echinococcus granulosus protein kinase c epsilon type 0.0093 0.007 0.0069
Onchocerca volvulus 0.0029 0.0007 0.0097
Brugia malayi Protein kinase domain containing protein 0.007 0.0047 0.0047
Onchocerca volvulus 0.0213 0.0188 0.2694
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0007 0.0008
Toxoplasma gondii histone deacetylase SIR2 0.0104 0.008 0.1905
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0043 0.0021 0.0494
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0104 0.008 0.1756
Loa Loa (eye worm) serpin 0.0023 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0029 0.0007 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0104 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0286 0.026 0.026
Brugia malayi Kelch motif family protein 0.0312 0.0286 0.0286
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0062 0.0039 0.0741
Brugia malayi Angiotensin-converting enzyme family protein 0.0646 0.0616 0.0616
Echinococcus multilocularis integrin alpha 3 0.0113 0.009 0.0111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Brugia malayi Pepsin A precursor 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.073 0.0699 0.0699
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0007 0.0006
Brugia malayi hypothetical protein 0.0026 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2468 0.2416 0.3954
Mycobacterium ulcerans polyketide synthase 0.0024 0.0002 0.0025
Echinococcus multilocularis serotonin receptor 0.0029 0.0007 0.0008
Onchocerca volvulus 0.0049 0.0026 0.0374
Plasmodium vivax NAD-dependent deacetylase, putative 0.0104 0.008 0.1756
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0007 0.0008
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0002 0.0025
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0007 0.0006
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0014 0.0144
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0007 0.0007
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.004 0.0017 0.0017
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0704 0.0674 0.0841
Schistosoma mansoni chromatin regulatory protein sir2 0.0104 0.008 0.008
Brugia malayi Stress-activated protein kinase jnk-1 0.0226 0.0201 0.0201
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0007 0.0007
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0002 0.0025
Onchocerca volvulus 0.073 0.0699 1
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0007 0.0008
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0104 0.008 0.1184
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0035 0.0012 0.0057
Echinococcus multilocularis somatostatin receptor 0.0029 0.0007 0.0008
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0226 0.0201 0.025
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0014 0.0014
Brugia malayi NAD-dependent deacetylase SIRT1 0.0104 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0003
Toxoplasma gondii subtilisin SUB5 0.0447 0.0419 1
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0062 0.0039 0.0909
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0007 0.0006
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0014 0.0144
Loa Loa (eye worm) hypothetical protein 0.007 0.0047 0.0047
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Toxoplasma gondii rhoptry neck protein RON1 0.0036 0.0013 0.0298
Schistosoma mansoni egf-like domain protein 0.0026 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.2021 0.1975 0.3231
Brugia malayi BmSERPIN, truncated 0.0023 0.0001 0.0001
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0007 0.0007
Leishmania major sir2-family protein-like protein 0.0104 0.008 0.1084
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0104 0.008 0.1084
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0039 0.0058
Onchocerca volvulus 0.0177 0.0153 0.2186
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.2021 0.1975 0.3231
Brugia malayi transcriptional regulator, Sir2 family protein 0.0704 0.0674 0.0674
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0007 0.0006
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0447 0.0419 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0137 0.0113 0.2546
Plasmodium falciparum plasmepsin IX 0.0037 0.0014 0.0144
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0007 0.0007
Plasmodium falciparum plasmepsin VII 0.0037 0.0014 0.0144
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0021 0.0301
Echinococcus granulosus serine:threonine protein kinase N2 0.0076 0.0053 0.0052
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0003 0.0072
Plasmodium falciparum plasmepsin V 0.0415 0.0388 0.9244
Echinococcus granulosus tissue type plasminogen activator 0.0031 0.0008 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0007 0.0006
Giardia lamblia High cysteine membrane protein Group 2 0.3735 0.3667 1
Toxoplasma gondii aspartyl protease 0.0037 0.0014 0.0323
Brugia malayi Furin-like cysteine rich region family protein 0.0656 0.0626 0.0626
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0104 0.008 0.1184
Schistosoma mansoni growth factor receptor-bound protein 0.0253 0.0228 0.0227
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0704 0.0674 1
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0104 0.008 0.0217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Echinococcus multilocularis integrin alpha ps 0.0066 0.0043 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0447 0.0419 0.0681
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.008 0.0127
Schistosoma mansoni c4b-binding protein beta chain 0.0036 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0137 0.0113 0.0113
Onchocerca volvulus 0.0036 0.0013 0.0189
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.0007 0.0097
Brugia malayi CUB domain containing protein 0.0026 0.0003 0.0003
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0137 0.0113 0.2681
Giardia lamblia High cysteine protein 0.0049 0.0026 0.0069
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Onchocerca volvulus 0.0029 0.0007 0.0097
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0003 0.0072
Echinococcus granulosus fmrfamide receptor 0.0029 0.0007 0.0006
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0002 0.0037
Brugia malayi hypothetical protein 0.0029 0.0007 0.0007
Entamoeba histolytica hypothetical protein, conserved 0.0104 0.008 0.1184
Schistosoma mansoni hypothetical protein 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0131 0.0107 0.0107
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) TK/ALK protein kinase 0.007 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Echinococcus granulosus somatostatin receptor 0.0029 0.0007 0.0006
Echinococcus granulosus MAM 0.007 0.0047 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0029
Brugia malayi sulfakinin receptor protein 0.0029 0.0007 0.0007
Brugia malayi Dopamine receptor protein 1 0.0029 0.0007 0.0007
Plasmodium falciparum plasmepsin III 0.0037 0.0014 0.0144
Schistosoma mansoni dock 0.0043 0.0021 0.002
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0021 0.002
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0447 0.0419 0.0419
Echinococcus multilocularis glutamate receptor NMDA 0.0095 0.0072 0.0089
Echinococcus granulosus neuropeptide receptor 0.0029 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Plasmodium vivax apical sushi protein, putative 0.0036 0.0013 0.0119
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0226 0.0201 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0007 0.0006

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.429 uM Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method ChEMBL. 18800760

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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