Detailed information for compound 1168160

Basic information

Technical information
  • TDR Targets ID: 1168160
  • Name: 4-[(3-chloro-4-methoxyphenyl)methylamino]-1-( 3-hydroxypropylamino)phthalazine-6-carbonitri le
  • MW: 397.858 | Formula: C20H20ClN5O2
  • H donors: 3 H acceptors: 4 LogP: 3.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCNc1nnc(c2c1ccc(c2)C#N)NCc1ccc(c(c1)Cl)OC
  • InChi: 1S/C20H20ClN5O2/c1-28-18-6-4-14(10-17(18)21)12-24-20-16-9-13(11-22)3-5-15(16)19(25-26-20)23-7-2-8-27/h3-6,9-10,27H,2,7-8,12H2,1H3,(H,23,25)(H,24,26)
  • InChiKey: GRKYNTUHYPDRLI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(3-chloro-4-methoxy-phenyl)methylamino]-1-(3-hydroxypropylamino)phthalazine-6-carbonitrile
  • 4-[(3-chloro-4-methoxyphenyl)methylamino]-1-(3-hydroxypropylamino)-6-phthalazinecarbonitrile
  • 4-[(3-chloro-4-methoxy-benzyl)amino]-1-(3-hydroxypropylamino)phthalazine-6-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0889 0.0923
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1649 0.9331 1
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0077 0.0183
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Brugia malayi Cytochrome P450 family protein 0.0025 0.0077 0.029
Trypanosoma brucei Emopamil binding protein, putative 0.0141 0.074 0.2119
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0077 0.0047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0148 0.0372
Entamoeba histolytica protein kinase domain containing protein 0.0195 0.1048 1
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.3972 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0137 0.0521
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0077 0.0047
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0074 0.0356 0.0825
Onchocerca volvulus 0.0023 0.0069 0.04
Onchocerca volvulus 0.0035 0.0137 0.0912
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0049 0.0124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0077
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0615 0.3438 1
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0077 0.0235
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0077 0.0235
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0251 0.0558
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0148 0.0505
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0077 0.018
Onchocerca volvulus 0.0097 0.0487 0.3519
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0077 0.0183
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1222 0.1195
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0521
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.0822 0.601
Leishmania major sterol 24-c-methyltransferase, putative 0.0615 0.3438 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0205
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0615 0.3438 1
Plasmodium falciparum polyprenol reductase, putative 0.0022 0.0061 0.0916
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.03 0.1643 0.6222
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0634 0.2359
Loa Loa (eye worm) beta-lactamase 0.0035 0.0137 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Leishmania major C-8 sterol isomerase-like protein 0.0378 0.2087 0.6053
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0077 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0115 0.029
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0111 0.0366
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0077 0.0047
Mycobacterium ulcerans methoxy mycolic acid synthase 2, MmaA2 0.004 0.0164 0.0594
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0615 0.3438 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Echinococcus multilocularis dna polymerase eta 0.002 0.0049 0.0019
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0701 0.072
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0111 0.028
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0701 0.2612
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0137 0.0473
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0148 0.0989
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0022 0.0061 0.0153
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0251 0.0236
Toxoplasma gondii ABC1 family protein 0.0035 0.0137 0.1346
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0077 0.0047
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0137 0.036
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0077 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0356 0.2541
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0069 0.0155
Echinococcus multilocularis synaptic glycoprotein sc2 0.0022 0.0061 0.0032
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0049 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0148 0.0989
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0346
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0022 0.0061 0.0376
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0141
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0122 0.0794
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0022 0.0061 0.0443
Toxoplasma gondii hypothetical protein 0.0023 0.007 0.0493
Trypanosoma brucei unspecified product 0.002 0.0049 0.0102
Loa Loa (eye worm) RecQ helicase 0.002 0.0052 0.0141
Loa Loa (eye worm) hypothetical protein 0.0053 0.0239 0.0854
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0077 0.0192
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.0889 0.3367
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.007 0.004
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0195 0.1048 0.3933
Brugia malayi Cytochrome P450 family protein 0.0025 0.0077 0.029
Onchocerca volvulus 0.0031 0.0115 0.0747
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.0356 0.0996
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0049 0.0019
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0077 0.0192
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0111 0.1013
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0077 0.0047
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.0222 0.1545
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0077 0.0047
Loa Loa (eye worm) hypothetical protein 0.0193 0.1036 0.3888
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0049 0.0019
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0049 0.0102
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0356 0.2541
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0509 0.0514
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0052 0.0053
Trypanosoma brucei Sterol methyltransferase, putative 0.0615 0.3438 1
Schistosoma mansoni hypothetical protein 0.008 0.0391 0.0984
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0022 0.0061 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0304 0.2157
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0391 0.1431
Mycobacterium ulcerans cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 0.004 0.0164 0.0594
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0358
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0148 0.0559
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0912
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0251 0.0558
Loa Loa (eye worm) twinkle helicase 0.0113 0.0582 0.2159
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0077 0.0192
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0077 0.0047
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0148 0.0989
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0141 0.074 0.2117
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0069 0.0155
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0251 0.0236
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0148 0.1476
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0052 0.0095
Echinococcus multilocularis hedgehog 0.0196 0.1051 0.1097
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0077 0.0192
Leishmania major protein kinase, putative 0.0074 0.0356 0.0996
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0122 0.0306
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0061 0.0134
Schistosoma mansoni DNA polymerase eta 0.002 0.0049 0.0124
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0069 0.026
Plasmodium vivax polyprenol reductase, putative 0.0022 0.0061 0.0916
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0251 0.0689
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0174
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0077 0.0192
Loa Loa (eye worm) hypothetical protein 0.004 0.0164 0.0566
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0251 0.0689
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0077 0.0192
Echinococcus multilocularis 0.0072 0.0344 0.0337
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0049 0.01
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0077 0.0192
Mycobacterium ulcerans cyclopropane-fatty-acyl-phospholipid synthase 0.004 0.0164 0.0594
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0148 0.0297
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0069 0.0157
Brugia malayi PHD-finger family protein 0.0031 0.0111 0.0421
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0049 0.0102
Loa Loa (eye worm) hypothetical protein 0.0252 0.1372 0.517
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0049 0.0019
Loa Loa (eye worm) hypothetical protein 0.0155 0.0822 0.3072
Brugia malayi Cytochrome P450 family protein 0.0025 0.0077 0.029
Mycobacterium ulcerans methoxy mycolic acid synthase 4, MmaA4 0.004 0.0164 0.0594
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0077 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0148 0.0989
Echinococcus granulosus GPCR family 2 0.008 0.0391 0.0913
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0141 0.074 0.2117
Echinococcus multilocularis bloom syndrome protein 0.002 0.0052 0.0023
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0155 0.0822 0.7811
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0049 0.013
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0052 0.0647
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0521
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.0356 0.0999
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0889 0.0923
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0077 0.0047
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0049 0.0064
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0108
Brugia malayi jmjC domain containing protein 0.0101 0.0509 0.1928
Echinococcus multilocularis dual specificity 0.0195 0.1048 0.1093
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0701 0.1764
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0111 0.0086
Schistosoma mansoni hypothetical protein 0.0097 0.0488 0.1228
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0033 0.0122 0.0461
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0077 0.0235
Loa Loa (eye worm) hypothetical protein 0.0031 0.0115 0.0382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0247 0.0549
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0077 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0148 0.0989
Trypanosoma cruzi Emopamil binding protein, putative 0.0141 0.074 0.2117
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0033 0.0122 0.0097
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Echinococcus granulosus peregrin 0.0031 0.0111 0.0203
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0052 0.0276
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0358
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0035 0.0005
Plasmodium vivax SET domain protein, putative 0.0031 0.0115 0.2595
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0031 0.0078
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0061 0.0916
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0122 0.0461
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0035 0.013
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0061 0.0916
Plasmodium falciparum phd finger protein, putative 0.0031 0.0111 0.2466
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0205
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0356 0.0896
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0488 0.1848
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0137 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0069 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0069 0.026
Mycobacterium ulcerans lipase LipD 0.0035 0.0137 0.0473
Treponema pallidum replicative DNA helicase (dnaB) 0.0397 0.2196 0.5
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0077 0.0192
Loa Loa (eye worm) hypothetical protein 0.0053 0.0236 0.0842
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0247 0.0623
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0356 0.0996
Schistosoma mansoni hypothetical protein 0.008 0.0391 0.0984
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0052 0.0276
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0366
Schistosoma mansoni cytochrome P450 0.0025 0.0077 0.0193
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0049 0.033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0069 0.052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0074 0.0356 0.0998
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.0889 0.3329
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0252 0.1372 0.5198
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0111 0.1013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0466
Leishmania major hypothetical protein, conserved 0.0141 0.074 0.2117
Echinococcus multilocularis 0.0025 0.0077 0.0049
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.0822 0.2356
Mycobacterium leprae putative cytochrome p450 0.0025 0.0077 0.0028
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0111 0.0203
Brugia malayi TAR-binding protein 0.0134 0.0701 0.2654
Schistosoma mansoni hypothetical protein 0.0533 0.2972 0.7483
Schistosoma mansoni alpha-glucosidase 0.0144 0.0756 0.1904
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.0356 0.0996
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0061 0.0341
Echinococcus granulosus dna polymerase kappa 0.002 0.0049 0.0046
Mycobacterium tuberculosis Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase) 0.004 0.0164 0.0134
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0049 0.0254
Loa Loa (eye worm) hypothetical protein 0.004 0.0164 0.0566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0247 0.0623
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Schistosoma mansoni hypothetical protein 0.008 0.0391 0.0984
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0115 0.1066
Leishmania major cytochrome p450-like protein 0.0025 0.0077 0.018
Mycobacterium leprae POSSIBLE FATTY ACID SYNTHASE 0.004 0.0164 0.0336
Onchocerca volvulus 0.0022 0.0061 0.0341
Entamoeba histolytica protein kinase, putative 0.0195 0.1048 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0137 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0049 0.0102
Onchocerca volvulus 0.004 0.0164 0.1108
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0251 0.1756
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0251 0.0689
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0251 0.2779
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0077 0.0028
Brugia malayi MH2 domain containing protein 0.0123 0.0634 0.2403
Brugia malayi isocitrate dehydrogenase 0.0017 0.0031 0.0117
Echinococcus granulosus tar DNA binding protein 0.0134 0.0701 0.1699
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.0918 0.3477
Mycobacterium leprae CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC AC 0.004 0.0164 0.0336
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0052 0.0647
Mycobacterium leprae Conserved hypothetical protein 0.052 0.2898 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0022 0.0061 0.0376
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0137 0.0243
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0077 0.0047
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0031 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0247 0.0623
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0251 0.0631
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0077 0.0047
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0137 0.0473
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0049 0.0064
Brugia malayi Bromodomain containing protein 0.0031 0.0111 0.0421
Mycobacterium leprae conserved hypothetical protein 0.0023 0.007 0.0004
Giardia lamblia Kinase, CMGC CLK 0.0074 0.0356 1
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0251 0.6573
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0052 0.0197
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0148 0.0372
Brugia malayi Pre-SET motif family protein 0.0219 0.1185 0.4486
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0251 0.0898
Echinococcus granulosus bloom syndrome protein 0.002 0.0052 0.0053
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.03 0.3408
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.0822 0.2356
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0052 0.0111
Brugia malayi Latrophilin receptor protein 2 0.008 0.0391 0.148
Echinococcus granulosus dual specificity protein kinase clk2 0.0074 0.0356 0.0824
Schistosoma mansoni hypothetical protein 0.0025 0.0077 0.0193
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0251 0.1756
Brugia malayi Cytochrome P450 family protein 0.0025 0.0077 0.029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0466
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0077 0.0047
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.3972 0.4237
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0077 0.0047
Mycobacterium leprae METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE) 0.004 0.0164 0.0336
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0346
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0141 0.074 0.2117
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.0822 0.601
Trypanosoma brucei C-8 sterol isomerase, putative 0.0378 0.2087 0.6054
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0378 0.2087 0.6053
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0077 0.0192
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.007 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0304 0.2157
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0615 0.3438 1
Schistosoma mansoni hypothetical protein 0.0031 0.0111 0.028
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0137 0.3276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0115 0.029
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0031 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0391 0.0913
Mycobacterium ulcerans hypothetical protein 0.0035 0.0137 0.0473
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0701 0.2612
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.03 0.1227
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0074 0.0356 0.4109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0252 0.1372 0.5198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0466
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0251 0.0691
Brugia malayi Synaptic glycoprotein SC2 0.0022 0.0061 0.023
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0195 0.1048 0.3017
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.018 0.016
Echinococcus granulosus Desert hedgehog protein 0.0196 0.1051 0.2589
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0022 0.0061 0.0032
Brugia malayi Protein kinase domain containing protein 0.0074 0.0356 0.1348
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0049 0.0186
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0251 0.0689
Loa Loa (eye worm) hypothetical protein 0.008 0.0391 0.1431
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0022 0.0061 0.0341
Loa Loa (eye worm) hypothetical protein 0.0475 0.264 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0391 0.0387
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0251 0.1756
Schistosoma mansoni alpha-glucosidase 0.0144 0.0756 0.1904
Mycobacterium leprae METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE) 0.004 0.0164 0.0336
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0266
Giardia lamblia PHD finger protein 15 0.0031 0.0111 0.2021
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0077 0.0192
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0195 0.1048 0.3017
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0077
Brugia malayi jmjC domain containing protein 0.0037 0.0148 0.056
Plasmodium falciparum protein serine/threonine kinase-1 0.0074 0.0356 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0912
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0069 0.0157
Echinococcus multilocularis GPCR, family 2 0.008 0.0391 0.0387
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0148 0.0989
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0074 0.0356 0.1298
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0031 0.0047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0115 0.0091
Toxoplasma gondii hypothetical protein 0.0065 0.0304 0.3459
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0069 0.052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0466
Mycobacterium ulcerans putative regulatory protein 0.0023 0.007 0.0161
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0049 0.01
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0466
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0148 0.0989
Brugia malayi beta-lactamase 0.0035 0.0137 0.0521
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0109 0.0197
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0137 0.0108
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0148 0.0989
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0615 0.3438 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Entamoeba histolytica hypothetical protein 0.0022 0.0061 0.0443
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0069 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0912
Mycobacterium tuberculosis Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac 0.004 0.0164 0.0134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0247 0.0233
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0397 0.2196 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0137 0.0108
Brugia malayi RNA binding protein 0.0134 0.0701 0.2654
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0251 0.1756
Onchocerca volvulus 0.0249 0.1357 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0356 0.0996
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0297 0.1075
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0155 0.0822 0.3111
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0148 0.0388
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0077 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0148 0.0506
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0077 0.0047
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.264 0.6621
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0252 0.1372 0.517
Mycobacterium tuberculosis Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase) 0.004 0.0164 0.0134
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0033 0.0122 0.023
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0052 0.0023
Brugia malayi hypothetical protein 0.0475 0.264 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0247 0.0885
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0069 0.0155
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.03 0.029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0108
Loa Loa (eye worm) hypothetical protein 0.0053 0.0239 0.0854
Onchocerca volvulus 0.0035 0.0137 0.0912
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.03 0.0756
Schistosoma mansoni survival motor neuron protein 0.0097 0.0488 0.1228
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0356 0.0996
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0122 0.0794
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0031 0.0047
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0205
Loa Loa (eye worm) RNA binding protein 0.0134 0.0701 0.2612
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0061 0.0341
Mycobacterium tuberculosis Possible mycolic acid synthase UmaA 0.004 0.0164 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0148 0.0388
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0049 0.01
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0122 0.0794
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0077 0.0235
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.0222 0.1545
Echinococcus granulosus hypothetical protein 0.0072 0.0344 0.0795
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0077 0.0192
Onchocerca volvulus 0.0097 0.0488 0.3523
Loa Loa (eye worm) hypothetical protein 0.0378 0.2087 0.7893
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0391 0.148
Echinococcus multilocularis dna polymerase kappa 0.002 0.0049 0.0019
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0049 0.0046
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0074 0.0356 0.035
Leishmania major protein kinase, putative 0.0074 0.0356 0.0996
Loa Loa (eye worm) cytochrome P450 0.0025 0.0077 0.0235
Plasmodium vivax hypothetical protein, conserved 0.0023 0.007 0.12
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0077 0.018
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0111 0.2466
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0148 0.0125
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0077 0.0192
Mycobacterium tuberculosis Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) 0.004 0.0164 0.0134
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0069 0.0157
Echinococcus multilocularis dual specificity protein kinase clk2 0.0074 0.0356 0.0349
Mycobacterium ulcerans hypothetical protein 0.0155 0.0822 0.3639
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0077 0.0192
Brugia malayi MAP kinase sur-1 0.0055 0.0251 0.095
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0031 0.0061
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0701 0.1764
Mycobacterium tuberculosis Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase) 0.004 0.0164 0.0134
Mycobacterium ulcerans beta-lactamase 0.0035 0.0137 0.0473
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0148 0.0296
Echinococcus granulosus dna polymerase eta 0.002 0.0049 0.0046
Mycobacterium ulcerans methoxy mycolic acid synthase 5 MmaA5 0.004 0.0164 0.0594
Loa Loa (eye worm) hypothetical protein 0.0193 0.1036 0.3889
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0022 0.0061 0.0341
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.0356 0.0996
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0247 0.0233
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0077 0.0192
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0077 0.0578
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0155 0.0822 0.2356
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.03 0.0834
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.0356 0.0996
Echinococcus multilocularis geminin 0.0533 0.2972 0.3163
Loa Loa (eye worm) hypothetical protein 0.03 0.1643 0.6201
Loa Loa (eye worm) hypothetical protein 0.0172 0.0918 0.344
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.1185 0.4455
Mycobacterium tuberculosis Possible fatty acid synthase 0.004 0.0164 0.0134
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.03 0.0684
Echinococcus multilocularis peregrin 0.0031 0.0111 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0304 0.2157
Echinococcus granulosus dual specificity 0.0195 0.1048 0.258
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0061 0.0136
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.03 0.1227
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0069 0.026
Schistosoma mansoni hypothetical protein 0.0172 0.0918 0.2311
Toxoplasma gondii GAF domain-containing protein 0.0023 0.007 0.0493
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Echinococcus granulosus microtubule associated protein 2 0.0708 0.3972 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0077 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0356 0.0896
Giardia lamblia Synaptic glycoprotein SC2 0.0022 0.0061 0.038
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0022 0.0061 0.0443
Brugia malayi Pre-SET motif family protein 0.0031 0.0115 0.0437
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0155 0.0822 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0164 0.0566
Mycobacterium tuberculosis Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) 0.004 0.0164 0.0134
Toxoplasma gondii hypothetical protein 0.0023 0.007 0.0493
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.007 0.12
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0397 0.2196 0.752
Mycobacterium ulcerans hypothetical protein 0.0023 0.0069 0.0155
Leishmania major DNA polymerase kappa, putative 0.002 0.0049 0.01
Mycobacterium ulcerans putative regulatory protein 0.0023 0.007 0.0161
Entamoeba histolytica protein kinase, putative 0.0195 0.1048 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0155 0.0822 0.2358
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0137 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0049 0.01
Schistosoma mansoni jumonji domain containing protein 0.008 0.0391 0.0985
Echinococcus granulosus jumonji domain containing protein 0.0043 0.018 0.0377
Brugia malayi Hint module family protein 0.0053 0.0239 0.0906
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0069 0.052
Brugia malayi Protein kinase domain containing protein 0.0195 0.1048 0.3968
Schistosoma mansoni alpha glucosidase 0.0037 0.0148 0.0372
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0077 0.0192
Mycobacterium ulcerans mycolic acid synthase PcaA 0.004 0.0164 0.0594
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0108
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0052 0.0053
Mycobacterium tuberculosis Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac 0.004 0.0164 0.0134
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0035 0.013
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0137 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0077 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0061 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0148 0.1285
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0148 0.0388
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0049 0.01
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0031 0.0047
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.0889 0.2177
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0052 0.0141
Onchocerca volvulus 0.0141 0.074 0.5401
Leishmania major DNA polymerase eta, putative 0.002 0.0049 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0077
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.0222 0.0606
Loa Loa (eye worm) hypothetical protein 0.0072 0.0344 0.1254
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0266
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.264 0.2806
Schistosoma mansoni Replicative DNA helicase 0.0397 0.2196 0.5529
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0077
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0077 0.0116
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0251 0.0689
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0137 0.0114
Plasmodium vivax serine/threonine kinase-1, putative 0.0074 0.0356 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0701 0.1764
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0049 0.0102
Loa Loa (eye worm) hypothetical protein 0.0033 0.0122 0.0406
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0397 0.2196 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0049 0.01
Brugia malayi Hint module family protein 0.0053 0.0239 0.0906
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0356 0.2541
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0074 0.0356 0.0998
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0115 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0069 0.0155
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0137 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0356 0.254
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0052 0.0276
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0137 0.027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0148 0.1285
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0015 0.0003
Schistosoma mansoni DNA helicase recq1 0.002 0.0052 0.0131
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0148 0.0989
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0069 0.0155
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.007 0.0161
Loa Loa (eye worm) hypothetical protein 0.0193 0.1036 0.3889
Leishmania major sterol 24-c-methyltransferase, putative 0.0615 0.3438 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0052 0.0108
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0022 0.0061 0.0153
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0077 0.018
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0378 0.2087 0.7905
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0031 0.0001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0074 0.0356 0.0999
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0049 0.0124
Brugia malayi cytochrome P450 0.0025 0.0077 0.029
Entamoeba histolytica recQ family helicase, putative 0.002 0.0052 0.0359
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Echinococcus granulosus synaptic glycoprotein sc2 0.0022 0.0061 0.0076
Mycobacterium ulcerans methoxy mycolic acid synthase 3, MmaA3 0.004 0.0164 0.0594
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0077 0.018
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.137 0.774 0.7733
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0049 0.0254
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0077 0.0047
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.03 0.0756
Schistosoma mansoni hypothetical protein 0.0533 0.2972 0.7483
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0077 0.0192
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.03 0.0271
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0052 0.0108
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0031 0.0049
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0356 0.2541
Mycobacterium tuberculosis Mycolic acid synthase PcaA (cyclopropane synthase) 0.004 0.0164 0.0134
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0137 0.0108
Mycobacterium ulcerans mycolic acid synthase UmaA 0.004 0.0164 0.0594
Echinococcus granulosus geminin 0.0533 0.2972 0.7463
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0247 0.0549
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0015 0.0057
Mycobacterium leprae Probable lipase LipE 0.0035 0.0137 0.0243
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0077 0.0047
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0509 0.1213
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0701 0.1764
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0247 0.0936
Onchocerca volvulus 0.0035 0.0137 0.0912
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0634 0.2359
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.1048 0.2638
Schistosoma mansoni hypothetical protein 0.0143 0.0748 0.1885
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0209
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0077 0.0192
Trypanosoma brucei protein kinase, putative 0.0055 0.0251 0.0691
Leishmania major hypothetical protein, conserved 0.0035 0.0137 0.0358
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.0822 0.601
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0115 0.029
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0356 0.2541
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0912
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0148 0.0126
Chlamydia trachomatis replicative DNA helicase 0.0397 0.2196 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.03 0.1227
Leishmania major cytochrome p450-like protein 0.0025 0.0077 0.018
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0022 0.0061 0.0076
Mycobacterium leprae MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) 0.004 0.0164 0.0336
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0321 0.1763 0.5106
Onchocerca volvulus Alhambra homolog 0.0031 0.0111 0.0716
Trichomonas vaginalis esterase, putative 0.0035 0.0137 0.0912
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0077 0.0192
Trypanosoma cruzi Emopamil binding protein, putative 0.0141 0.074 0.2117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0115 0.029
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.004 0.0164 0.0434
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0069 0.0039
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0701 0.2654
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0251 0.0689
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0077 0.0192
Trypanosoma brucei glucosidase, putative 0.0037 0.0148 0.039
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0077 0.0192
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0195 0.1048 0.3018
Schistosoma mansoni hypothetical protein 0.008 0.0391 0.0984
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1357 1
Schistosoma mansoni DNA helicase recq5 0.002 0.0052 0.0131
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0195 0.1048 0.3017
Entamoeba histolytica hypothetical protein 0.0195 0.1048 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0069 0.0155
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0912
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0074 0.0356 0.0896
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0466
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0701 0.1764
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0115 0.0091
Leishmania major cytochrome p450-like protein 0.0025 0.0077 0.018
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0077 0.0192
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0391 0.0913
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0052 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0391 0.0387
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0049 0.0102

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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