Detailed information for compound 1406805

Basic information

Technical information
  • TDR Targets ID: 1406805
  • Name: N-(8-methoxy-4,5-dihydrobenzo[e][1,3]benzothi azol-2-yl)thiophene-2-carboxamide
  • MW: 342.435 | Formula: C17H14N2O2S2
  • H donors: 1 H acceptors: 2 LogP: 4.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1nc(sc1CC2)NC(=O)c1cccs1
  • InChi: 1S/C17H14N2O2S2/c1-21-11-6-4-10-5-7-13-15(12(10)9-11)18-17(23-13)19-16(20)14-3-2-8-22-14/h2-4,6,8-9H,5,7H2,1H3,(H,18,19,20)
  • InChiKey: HCEJYOCZRGKHPM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(8-methoxy-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)-2-thiophenecarboxamide
  • SMR000109970
  • ZINC00200005
  • EU-0082075
  • MLS000114081

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pyruvate kinase 0.004 0.0323 0.0982
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0239 0.0726
Schistosoma mansoni pyruvate kinase 0.0021 0.0124 0.0149
Mycobacterium ulcerans hypothetical protein 0.0029 0.0205 0.03
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.001 0.0013 0.0015
Leishmania major cytochrome p450-like protein 0.0032 0.0239 0.2997
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.001 0.0013 0.0018
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.001 0.0013 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0131 0.0192
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0131 0.0192
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0617 0.0903
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0131 0.0192
Trypanosoma cruzi cdc2-related kinase 1 0.0087 0.0796 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0156 0.0187
Mycobacterium tuberculosis Conserved hypothetical protein 0.001 0.0013 0.0018
Plasmodium vivax pyruvate kinase, putative 0.004 0.0323 0.4058
Giardia lamblia Kinase, CMGC CDK 0.0087 0.0796 0.1149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.04
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0607 0.0888
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8364 1
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0239 0.2997
Mycobacterium ulcerans hypothetical protein 0.0682 0.6832 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0037 0.0045
Giardia lamblia Pyruvate kinase 0.004 0.0323 0.0455
Echinococcus granulosus patatin phospholipase domain containing protein 0.001 0.0013 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0796 0.1166
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0039 0.0056
Loa Loa (eye worm) hypothetical protein 0.0085 0.0772 0.2346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0039 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0039 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0039 0.0117
Plasmodium falciparum pyruvate kinase 0.004 0.0323 0.4058
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0039 0.0056
Brugia malayi TAR-binding protein 0.0076 0.069 0.101
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.001 0.0013 0.0158
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0039 0.0056
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0131 0.0192
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.0001 0.0001
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.001 0.0013 0.0158
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0131 0.0192
Mycobacterium leprae Conserved hypothetical protein 0.001 0.0013 0.0018
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0132 0.3834
Echinococcus multilocularis geminin 0.0205 0.199 0.2379
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0132 0.0193
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0723 0.0865
Echinococcus multilocularis tar DNA binding protein 0.0076 0.069 0.0825
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0617 0.7748
Schistosoma mansoni cpg binding protein 0.0035 0.0266 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0039 0.0117
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0039 0.0046
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0131 0.0192
Schistosoma mansoni hypothetical protein 0.0021 0.0131 0.0157
Giardia lamblia Transglutaminase/protease, putative 0.0682 0.6832 1
Mycobacterium leprae putative cytochrome p450 0.0021 0.0131 0.0192
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.001 0.0013 0.0158
Loa Loa (eye worm) hypothetical protein 0.0029 0.0205 0.0623
Schistosoma mansoni pyruvate kinase 0.004 0.0323 0.0386
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0323 0.4058
Echinococcus granulosus cpg binding protein 0.0037 0.0286 0.0342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0475 0.0568
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0323 0.4058
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0131 0.165
Brugia malayi cytochrome P450 0.0021 0.0131 0.0192
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0617 0.0903
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.001 0.0013 0.0015
Schistosoma mansoni hypothetical protein 0.001 0.0013 0.0015
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0131 0.0192
Trypanosoma brucei cdc2-related kinase 1 0.0087 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0038
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0124 0.1562
Brugia malayi pyruvate kinase 0.0008 0.0001 0.0001
Leishmania major pyruvate kinase 0.004 0.0323 0.4058
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0323 0.0323
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0131 0.0192
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0039 0.0056
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0796 0.1166
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.001 0.0013 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0002 0.0003
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.001 0.0013 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0039 0.0056
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0039 0.0046
Trypanosoma brucei cdc2-related kinase 3 0.0087 0.0796 1
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0156 0.1961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0039 0.0117
Mycobacterium tuberculosis Conserved protein 0.001 0.0013 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0682 0.6832 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0087 0.0796 0.0952
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0205 0.2574
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0039 0.0117
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.02 0.0607
Brugia malayi Cytochrome P450 family protein 0.0032 0.0239 0.0349
Schistosoma mansoni tar DNA-binding protein 0.0076 0.069 0.0825
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0661 0.079
Schistosoma mansoni tar DNA-binding protein 0.0076 0.069 0.0825
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0039 0.0046
Mycobacterium ulcerans pyruvate kinase 0.004 0.0323 0.0473
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0617 0.0738
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0061 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0131 0.0192
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.001 0.0013 0.0158
Echinococcus multilocularis patatin phospholipase domain containing protein 0.001 0.0013 0.0015
Echinococcus multilocularis pyruvate kinase 0.0021 0.0124 0.0149
Leishmania major protein kinase, putative 0.0012 0.0037 0.0468
Mycobacterium ulcerans hypothetical protein 0.001 0.0013 0.0018
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0156 0.0187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0475 0.0568
Onchocerca volvulus 0.0012 0.0039 0.0039
Schistosoma mansoni pyruvate kinase 0.004 0.0323 0.0386
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0131 0.0192
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0061 0.0073
Leishmania major hypothetical protein, unknown function 0.001 0.0013 0.0158
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0323 0.0473
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0028
Loa Loa (eye worm) pyruvate kinase 0.004 0.0323 0.0982
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0039 0.0056
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0073 0.0655 0.0784
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0131 0.0192
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0131 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0393
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0131 0.0192
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0131 0.0192
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.001 0.0013 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0002 0.0003
Schistosoma mansoni rab6-interacting 0.0024 0.0156 0.0187
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0131 0.165
Onchocerca volvulus 0.0024 0.0156 0.0156
Schistosoma mansoni 60S ribosomal protein L21 0.0012 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0038
Echinococcus multilocularis cyclin dependent kinase 5 0.0087 0.0796 0.0952
Brugia malayi Protein kinase domain containing protein 0.0333 0.329 0.4815
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.012 0.0175
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0077 0.0696 0.0832
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.04
Onchocerca volvulus 0.0035 0.0266 0.0266
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0039 0.0039
Treponema pallidum catabolite gene activator (Crp) 0.001 0.0013 0.5
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0129 0.0155
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.001 0.0013 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0039 0.0056
Plasmodium falciparum cGMP-dependent protein kinase 0.0012 0.0037 0.0468
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0129 0.0155
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0022 0.0032
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0131 0.0192
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0061 0.0073
Giardia lamblia Pyruvate kinase 0.0021 0.0124 0.0164
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0581 0.7294
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0061 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0076 0.069 0.0825
Echinococcus multilocularis cyclin dependent kinase 1 0.0087 0.0796 0.0952
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0039 0.0056
Entamoeba histolytica protein kinase, putative 0.0077 0.0696 0.8737
Loa Loa (eye worm) RNA binding protein 0.0076 0.069 0.2098
Schistosoma mansoni tar DNA-binding protein 0.0076 0.069 0.0825
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0117
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8364 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0323 0.0473
Schistosoma mansoni lipoxygenase 0.0067 0.0591 0.0706
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0131 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0117
Treponema pallidum catabolite gene activator 0.001 0.0013 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0205 0.0623
Mycobacterium ulcerans hypothetical protein 0.001 0.0013 0.0018
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0131 0.0192
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0475 0.0695
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0039 0.0056
Treponema pallidum cyclic nucleotide binding protein 0.001 0.0013 0.5
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.001 0.0013 0.0158
Schistosoma mansoni hypothetical protein 0.0494 0.4923 0.5886
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0061 0.0073
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0131 0.0192
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0131 0.0192
Echinococcus multilocularis cyclin dependent kinase 0.0087 0.0796 0.0952
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0061 0.0073
Brugia malayi cell division control protein 2 homolog 0.0087 0.0796 0.1166
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0696 0.0832
Brugia malayi nuclear receptor NHR-88 0.0012 0.0039 0.0056
Entamoeba histolytica cell division protein kinase 2, putative 0.0087 0.0796 1
Trypanosoma brucei pyruvate kinase 1 0.004 0.0323 0.4058
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0131 0.0192
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.001 0.0013 0.0158
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4923 0.5886
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.001 0.0013 0.0015
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0129 0.0155
Echinococcus granulosus pyruvate kinase 0.0021 0.0124 0.0149
Loa Loa (eye worm) hypothetical protein 0.0024 0.0156 0.0475
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.001 0.0013 0.0158
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0039 0.0117
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.0013 0.0015
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0617 0.0738
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.04
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0205 0.2574
Echinococcus multilocularis pyruvate kinase 0.0021 0.0124 0.0149
Trypanosoma cruzi Flagellar Member 6 0.001 0.0013 0.0158
Mycobacterium leprae Conserved hypothetical protein 0.0682 0.6832 1
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.001 0.0013 0.0018
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0039 0.0046
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0132 0.1653
Schistosoma mansoni rab6-interacting 0.0024 0.0156 0.0187
Giardia lamblia Hypothetical protein 0.0682 0.6832 1
Leishmania major cytochrome p450-like protein 0.0021 0.0131 0.165
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0323 0.4058
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0131 0.0192
Schistosoma mansoni tar DNA-binding protein 0.0076 0.069 0.0825
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0037 0.0045
Echinococcus multilocularis pyruvate kinase 0.004 0.0323 0.0386
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0061 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0475 0.0568
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0039 0.0046
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0131 0.165
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.5577 0.6667
Loa Loa (eye worm) pyruvate kinase 0.0008 0.0001 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0039 0.0046
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0239 0.0726
Brugia malayi hypothetical protein 0.0024 0.0156 0.0229
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0205 0.03
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0039 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0039 0.0056
Loa Loa (eye worm) cytochrome P450 0.0021 0.0131 0.0399
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0087 0.0796 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0087 0.0796 0.2421
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0205 0.03
Brugia malayi CXXC zinc finger family protein 0.0035 0.0266 0.039
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0131 0.0192
Brugia malayi Cytochrome P450 family protein 0.0067 0.0599 0.0876
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0073 0.0655 0.0784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0039 0.0117
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0038 0.0056
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0131 0.0192
Loa Loa (eye worm) pyruvate kinase 0.004 0.0323 0.0982
Mycobacterium ulcerans transglutaminase family protein 0.0682 0.6832 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.012 0.0175
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0156 0.1961
Mycobacterium ulcerans regulatory protein 0.001 0.0013 0.0018
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0037 0.0045
Brugia malayi steroid hormone receptor 0.0012 0.0039 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0039 0.0046
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0061 0.009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0039 0.0046
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0156 0.0187
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0039 0.0046
Schistosoma mansoni loxhd1 0.0024 0.0156 0.0187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0205 0.03
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0131 0.0192
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0239 0.0726
Onchocerca volvulus 0.0029 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0063 0.0558 0.1695
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0039 0.0046
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.001 0.0013 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0475 0.0568
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0599 0.182
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.001 0.0013 0.0015
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0591 0.0706
Echinococcus granulosus pyruvate kinase 0.004 0.0323 0.0386
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0117
Mycobacterium ulcerans hypothetical protein 0.001 0.0013 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0129 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0039 0.0056
Leishmania major hypothetical protein, conserved 0.001 0.0013 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0205 0.03
Onchocerca volvulus 0.001 0.0013 0.0013
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0156 0.0475
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0061 0.009
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0087 0.0796 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.001 0.0013 0.0015
Trypanosoma cruzi protein kinase A regulatory subunit 0.001 0.0013 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0796 0.0952
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.001 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0117
Trypanosoma brucei cAMP response protein 1, putative 0.001 0.0013 0.0158
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0039 0.0046
Loa Loa (eye worm) AGC/PKG protein kinase 0.0012 0.0037 0.0113
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0037 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.001 0.0013 0.0018
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0131 0.165
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0205 0.03
Brugia malayi Protein kinase domain containing protein 0.0087 0.0796 0.1166
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0012 0.0037 0.0468
Schistosoma mansoni polycystin 1-related 0.0024 0.0156 0.0187
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0617 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0013 0.0018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0205 0.03
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0205 0.03
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0131 0.0192
Echinococcus multilocularis pyruvate kinase 0.0032 0.0237 0.0284
Schistosoma mansoni similar to Protein C20orf152 homolog 0.001 0.0013 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0039 0.0117
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0009 0.0007 0.0094
Echinococcus multilocularis pyruvate kinase 0.0021 0.0124 0.0149
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0039 0.0046
Onchocerca volvulus 0.001 0.0013 0.0013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0205 0.03
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8364 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0131 0.0192
Leishmania major protein kinase, putative 0.0012 0.0037 0.0468
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.001 0.0013 0.0018
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0323 0.0473
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.04
Trypanosoma cruzi cdc2-related kinase 1 0.0087 0.0796 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0156 0.0187
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0039 0.0039
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0131 0.0192
Treponema pallidum cyclic nucleotide binding protein 0.001 0.0013 0.5
Mycobacterium ulcerans hypothetical protein 0.001 0.0013 0.0018
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0131 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.04
Onchocerca volvulus 0.0024 0.0156 0.0156
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.057 0.1732
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0132 0.1653
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0323 0.0323
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.001 0.0013 0.0018
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0037 0.0045
Echinococcus multilocularis 0.0021 0.0131 0.0157
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0323 0.0473
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0061 0.0073
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0039 0.0046
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0205 0.03
Mycobacterium ulcerans transcriptional regulatory protein 0.001 0.0013 0.0018
Echinococcus multilocularis RUN 0.0024 0.0156 0.0187
Loa Loa (eye worm) hypothetical protein 0.0029 0.0205 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0039 0.0056
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0077 0.0696 0.0832
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0131 0.0192
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0205 0.03
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0205 0.2574
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0039 0.0046
Brugia malayi Egg laying defective protein 4 0.0012 0.0037 0.0055
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.001 0.0013 0.0158
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0039 0.0046
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0239 0.0349
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0131 0.0192
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0323 0.0473
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0266 0.081
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0037 0.0045
Schistosoma mansoni lipoxygenase 0.0024 0.0156 0.0187
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0039 0.0046
Leishmania major pyruvate kinase 0.004 0.0323 0.4058
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0117
Leishmania major cytochrome p450-like protein 0.0021 0.0131 0.165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0475 0.0568
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0087 0.0796 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0037 0.0045
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0039 0.0046
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0323 0.0473
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0475 0.1443
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0039 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0131 0.0192
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4923 0.5886
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0131 0.0192
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0039 0.0046
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0061 0.0186
Echinococcus multilocularis pyruvate kinase 0.004 0.0323 0.0386
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0132 0.0193
Giardia lamblia Kinase, CMGC CDK 0.0087 0.0796 0.1149
Entamoeba histolytica cell division protein kinase 2, putative 0.0087 0.0796 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0039 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0039 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0131 0.0192
Trypanosoma brucei cAMP binding protein, putative 0.001 0.0013 0.0158
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0323 0.0323
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.001 0.0013 0.0158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.012 0.0175
Mycobacterium tuberculosis Conserved hypothetical protein 0.0682 0.6832 1
Echinococcus granulosus pyruvate kinase 0.0021 0.0124 0.0149
Echinococcus granulosus geminin 0.0205 0.199 0.2379
Entamoeba histolytica protein kinase, putative 0.0077 0.0696 0.8737
Echinococcus granulosus cyclin dependent kinase 1 0.0087 0.0796 0.0952
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0131 0.165
Trypanosoma cruzi cdc2-related kinase 3 0.0087 0.0796 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.001 0.0013 0.0158
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0205 0.03
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0617 0.0903
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0205 0.2574
Brugia malayi Cytochrome P450 family protein 0.0021 0.0131 0.0192
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0087 0.0796 0.2421
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.001 0.0013 0.0018
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.069 0.101
Schistosoma mansoni cpg binding protein 0.0037 0.0286 0.0342
Schistosoma mansoni hypothetical protein 0.0205 0.199 0.2379
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0039 0.0039
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0131 0.165
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0028
Schistosoma mansoni hypothetical protein 0.0205 0.199 0.2379
Onchocerca volvulus 0.0013 0.0047 0.0047
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0323 0.4058
Mycobacterium ulcerans putative transglutaminase-like protein 0.0682 0.6832 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.001 0.0013 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0131 0.0192
Echinococcus granulosus Transglutaminase 0.0682 0.6832 0.8169
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.5577 0.6667
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.069 0.2098
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.001 0.0013 0.0018
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0061 0.0073
Echinococcus multilocularis expressed conserved protein 0.0012 0.0037 0.0045
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.001 0.0013 0.0015
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.001 0.0013 0.0015
Trypanosoma cruzi cdc2-related kinase 3 0.0087 0.0796 1
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.001 0.0013 0.0015
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0061 0.0073
Mycobacterium ulcerans transmembrane transport protein 0.001 0.0013 0.0018
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.001 0.0013 0.0018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0607 0.0888
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0239 0.2997
Echinococcus granulosus pyruvate kinase 0.004 0.0323 0.0386
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0205 0.03
Mycobacterium leprae Conserved hypothetical protein 0.0682 0.6832 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0039 0.0117
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.001 0.0013 0.0015
Chlamydia trachomatis pyruvate kinase 0.004 0.0323 1
Brugia malayi ecdysteroid receptor 0.0012 0.0039 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.012 0.0175
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.001 0.0013 0.0158
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0039 0.0046
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.001 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0067
Schistosoma mansoni hypothetical protein 0.0682 0.6832 0.8169
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0129 0.0155
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.001 0.0013 0.0018
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0077 0.0696 0.0832
Schistosoma mansoni coup transcription factor 0.0012 0.0039 0.0046
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0039 0.0046
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0039 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0131 0.0192
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0239 0.2997
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.001 0.0013 0.0015
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0129 0.0189
Echinococcus granulosus pyruvate kinase 0.0021 0.0124 0.0149
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0039 0.0046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0039 0.0046
Loa Loa (eye worm) TAR-binding protein 0.0076 0.069 0.2098
Trypanosoma cruzi cAMP binding protein, putative 0.001 0.0013 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.0333 0.329 0.3934
Echinococcus granulosus cyclin dependent kinase 5 0.0087 0.0796 0.0952
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0061 0.0073
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.001 0.0013 0.0015
Trypanosoma cruzi cAMP response protein 1 0.001 0.0013 0.0158
Echinococcus multilocularis cpg binding protein 0.0037 0.0286 0.0342
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0156 0.0187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0475 0.0568
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0205 0.03
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0205 0.2574
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0131 0.0192
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0607
Echinococcus multilocularis Transglutaminase 0.0682 0.6832 0.8169
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0024 0.0072
Trypanosoma brucei protein kinase A regulatory subunit 0.001 0.0013 0.0158
Mycobacterium ulcerans hypothetical protein 0.0682 0.6832 1
Leishmania major hypothetical protein, conserved 0.001 0.0013 0.0158
Brugia malayi Cytochrome P450 family protein 0.0032 0.0239 0.0349
Brugia malayi N-terminal motif family protein 0.001 0.0013 0.0018
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0617 0.0903
Brugia malayi Thioredoxin family protein 0.0682 0.6832 1
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0032 0.0038
Brugia malayi nuclear hormone receptor 0.0012 0.0039 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0039 0.0046
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.001 0.0013 0.0158
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0087 0.0796 0.0952
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0796 0.0952
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0061 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0131 0.0192
Trypanosoma brucei Flagellar Member 6 0.001 0.0013 0.0158
Echinococcus granulosus neuropeptide s receptor 0.0558 0.5577 0.6667
Brugia malayi RNA binding protein 0.0076 0.069 0.101
Schistosoma mansoni cpg binding protein 0.0037 0.0286 0.0342
Echinococcus granulosus cyclin dependent kinase 0.0087 0.0796 0.0952
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0077 0.0696 0.0832
Mycobacterium tuberculosis Conserved protein 0.0682 0.6832 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0039 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0796 0.1166
Plasmodium falciparum protein kinase 5 0.0087 0.0796 1
Mycobacterium tuberculosis Hypothetical protein 0.0682 0.6832 1
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0124 0.1562
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0205 0.03
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0475 0.0568
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0037 0.0045
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0131 0.0192
Leishmania major protein kinase A regulatory subunit, putative 0.001 0.0013 0.0158
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0156 0.0475
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0129 0.0155
Echinococcus granulosus tar DNA binding protein 0.0076 0.069 0.0825
Leishmania major cyclic nucleotide-binding protein-like protein 0.001 0.0013 0.0158
Echinococcus granulosus RUN 0.0024 0.0156 0.0187
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.001 0.0013 0.0018
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0061 0.0073
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0061 0.0073
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.001 0.0013 0.0013
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0131 0.0192
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0087 0.0796 0.2421
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0205 0.2574
Mycobacterium tuberculosis Long conserved protein 0.0682 0.6832 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0156 0.0187
Schistosoma mansoni hypothetical protein 0.0024 0.0156 0.0187
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0039 0.0046
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.001 0.0013 0.0015
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.001 0.0013 0.0015
Leishmania major hypothetical protein, conserved 0.001 0.0013 0.0158
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0723 0.0865
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.5577 0.6667
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0131 0.0192
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0061 0.0073
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0333 0.329 1
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0124 0.1562
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.004 0.0323 0.0982
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0131 0.0192
Plasmodium vivax protein kinase Crk2 0.0087 0.0796 1
Brugia malayi Doublecortin family protein 0.0024 0.0156 0.0229
Trypanosoma cruzi cAMP response protein 1, putative 0.001 0.0013 0.0158
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0591 0.0706
Leishmania major regulatory subunit of protein kinase a-like protein 0.001 0.0013 0.0158
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0131 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0013 0.0158
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0073 0.0655 0.0959
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0039 0.0056
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0117
Brugia malayi hypothetical protein 0.0024 0.0156 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0039 0.0046
Trichomonas vaginalis peptide N-glycanase, putative 0.0682 0.6832 1
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.02 0.2506
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0073 0.0655 0.1992
Schistosoma mansoni cytochrome P450 0.0021 0.0131 0.0157
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.001 0.0013 0.0158

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 0.794328235 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.818382931 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.818382931 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 6.309573445 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) = 21.7 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim23-1 yeast via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463212, AID463216, AID504657, AID504672] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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