Detailed information for compound 1606880

Basic information

Technical information
  • TDR Targets ID: 1606880
  • Name: (5E)-N-(2,6-dimethylphenyl)-7-(4-fluorophenyl )-5-[(2-hydrazinyl-2-oxoacetyl)hydrazinyliden e]-7-oxoheptanamide
  • MW: 455.482 | Formula: C23H26FN5O4
  • H donors: 4 H acceptors: 4 LogP: 2.69 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=O)C(=O)N/N=C(/CC(=O)c1ccc(cc1)F)\CCCC(=O)Nc1c(C)cccc1C
  • InChi: 1S/C23H26FN5O4/c1-14-5-3-6-15(2)21(14)26-20(31)8-4-7-18(28-29-23(33)22(32)27-25)13-19(30)16-9-11-17(24)12-10-16/h3,5-6,9-12H,4,7-8,13,25H2,1-2H3,(H,26,31)(H,27,32)(H,29,33)/b28-18+
  • InChiKey: YDUAWSZWERROOO-MTDXEUNCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazinyl-2-oxoacetyl)hydrazinylidene]-7-oxoheptanamide
  • N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazino-2-oxo-acetyl)hydrazono]-7-oxo-heptanamide
  • (5E)-N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazino-2-oxo-acetyl)hydrazono]-7-oxo-heptanamide
  • (5E)-N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazino-1,2-dioxoethyl)hydrazono]-7-oxoheptanamide
  • N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazino-1,2-dioxoethyl)hydrazono]-7-oxoheptanamide
  • (5E)-N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazino-2-keto-acetyl)hydrazono]-7-keto-enanthamide
  • N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazino-2-keto-acetyl)hydrazono]-7-keto-enanthamide
  • (5E)-N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazinyl-2-oxo-ethanoyl)hydrazinylidene]-7-oxo-heptanamide
  • N-(2,6-dimethylphenyl)-7-(4-fluorophenyl)-5-[(2-hydrazinyl-2-oxo-ethanoyl)hydrazinylidene]-7-oxo-heptanamide
  • NCI60_010572
  • AIDS-134355
  • AIDS134355
  • N-(2,6-Dimethylphenyl)-7-(4-fluorophenyl)-5-((hydrazino(oxo)acetyl)hydrazono)-7-oxoheptanamide
  • NSC632022

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cdc2-related kinase 1 0.0122 0.0506 0.1404
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0047 0.0029 0.0024
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0064 0.0139 0.0134
Brugia malayi protein unc-22 0.0043 0.0006 0.0001
Schistosoma mansoni hypothetical protein 0.1627 1 1
Echinococcus granulosus serine:threonine protein kinase 0.0117 0.0473 0.0469
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0532 0.3088 0.3085
Trypanosoma cruzi hypothetical protein, conserved 0.0579 0.3385 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.0015
Schistosoma mansoni ste20-related kinase 0.0217 0.1099 0.1099
Brugia malayi STE20-like kinase MST 0.0273 0.1455 0.1451
Schistosoma mansoni protein kinase 0.0102 0.0377 0.0377
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0053 0.0064 0.0059
Loa Loa (eye worm) hypothetical protein 0.0078 0.0226 0.0221
Echinococcus granulosus twitchin 0.0093 0.0322 0.0317
Echinococcus multilocularis Immunoglobulin 0.0053 0.0065 0.006
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1627 1 1
Schistosoma mansoni hypothetical protein 0.1627 1 1
Entamoeba histolytica protein kinase, putative 0.0071 0.0183 0.1065
Brugia malayi Protein kinase domain containing protein 0.0259 0.1364 0.136
Trichomonas vaginalis CK1 family protein kinase 0.0111 0.0436 0.04
Entamoeba histolytica serine/threonine protein kinase, putative 0.0066 0.0148 0.0837
Trichomonas vaginalis AGC family protein kinase 0.0141 0.0625 0.059
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0052 0.0064 0.0059
Giardia lamblia Kinase, NEK 0.0141 0.0625 0.3891
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0363 0.2023 0.2019
Entamoeba histolytica cell division protein kinase 2, putative 0.0122 0.0506 0.3178
Schistosoma mansoni TRABID protein (C64 family) 0.0579 0.3385 0.3385
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0048 0.0037 0.0007
Echinococcus granulosus c-Jun N-terminal kinases 0.0281 0.1506 0.1502
Echinococcus granulosus protein kinase c epsilon type 0.0192 0.0947 0.0942
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.0644 0.0609
Onchocerca volvulus Serine\/threonine kinase homolog 0.0288 0.1547 0.1543
Echinococcus granulosus epidermal growth factor receptor 0.017 0.0806 0.0801
Brugia malayi Stress-activated protein kinase jnk-1 0.0281 0.1506 0.1502
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1627 1 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0111 0.0436 0.0431
Echinococcus granulosus dual specificity protein kinase clk2 0.016 0.0745 0.0741
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0064 0.0064
Echinococcus multilocularis tumor protein p63 0.1372 0.8389 0.8388
Schistosoma mansoni vesicular amine transporter 0.0053 0.0065 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0377 0.2336
Trypanosoma cruzi Protein kinase B 0.0142 0.0629 0.1772
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0066 0.0148 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0148 0.0148
Brugia malayi Protein kinase domain containing protein 0.016 0.0745 0.0741
Echinococcus multilocularis epidermal growth factor receptor 0.0246 0.1283 0.1278
Loa Loa (eye worm) AGC/PKA protein kinase 0.0073 0.0191 0.0185
Brugia malayi serine/threonine-protein kinase PAK 7 0.0246 0.1285 0.128
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0144 0.0644 0.1819
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0215 0.1091 0.1087
Brugia malayi Casein kinase II, alpha chain 0.0102 0.0377 0.0372
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0122 0.0506 0.0486
Schistosoma mansoni ephrin receptor 0.0089 0.0293 0.0293
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0085 0.0271 0.0703
Brugia malayi probable protein kinase 0.0282 0.151 0.1506
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0129 0.0546 0.1524
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0073 0.0191 0.0464
Trypanosoma cruzi WLM domain containing protein, putative 0.0579 0.3385 1
Giardia lamblia Kinase, NEK 0.0141 0.0625 0.3891
Schistosoma mansoni protein kinase 0.0048 0.0035 0.0035
Echinococcus granulosus nervana 2 0.0105 0.0394 0.0389
Echinococcus granulosus neuroglian 0.0064 0.0139 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0651 0.0616
Schistosoma mansoni protein kinase 0.0203 0.1015 0.1015
Loa Loa (eye worm) AGC/PKN protein kinase 0.0287 0.1542 0.1538
Schistosoma mansoni serine/threonine-protein kinase 0.0142 0.0629 0.0629
Echinococcus multilocularis dual specificity 0.0144 0.0644 0.064
Trichomonas vaginalis AGC family protein kinase 0.0259 0.1364 0.1332
Giardia lamblia Kinase 0.0058 0.0101 0.0422
Brugia malayi protein kinase C II. 0.0192 0.0947 0.0942
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0377 0.0341
Echinococcus multilocularis mitogen activated protein kinase 3 0.0084 0.0264 0.026
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0073 0.0191 0.0186
Giardia lamblia Kinase, CAMK CAMKL 0.0066 0.0148 0.0734
Schistosoma mansoni fusion 0.0579 0.3385 0.3385
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0382 0.0346
Onchocerca volvulus Tyrosine kinase homolog 0.0371 0.2074 0.207
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0084 0.0264 0.0685
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.0644 0.0609
Schistosoma mansoni protein kinase 0.0087 0.028 0.028
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0122 0.0506 0.05
Schistosoma mansoni unc-13 (munc13) 0.0047 0.0029 0.0029
Trypanosoma cruzi cdc2-related kinase 3 0.0122 0.0506 0.1404
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0084 0.0264 0.0685
Echinococcus granulosus dual specificity 0.0144 0.0644 0.064
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Brugia malayi Fes/CIP4 homology domain containing protein 0.0085 0.0269 0.0264
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0249 0.1305 0.13
Plasmodium falciparum calcium-dependent protein kinase 2 0.0103 0.0382 0.0348
Schistosoma mansoni protein kinase 0.0217 0.1104 0.1104
Echinococcus multilocularis expressed protein 0.0084 0.026 0.0255
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0166 0.0783 0.2232
Brugia malayi intracellular kinase 0.0133 0.0574 0.0569
Echinococcus granulosus protein kinase shaggy 0.0133 0.0574 0.0569
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0145 0.0651 0.0646
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0052 0.0064 0.0058
Brugia malayi Furin-like cysteine rich region family protein 0.0246 0.1283 0.1278
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0377 0.2113 0.2109
Loa Loa (eye worm) CAMK/PKD protein kinase 0.023 0.1185 0.118
Entamoeba histolytica protein kinase, putative 0.0103 0.0382 0.2369
Brugia malayi Protein kinase domain containing protein 0.0203 0.1015 0.101
Trichomonas vaginalis AGC family protein kinase 0.0259 0.1364 0.1332
Loa Loa (eye worm) hypothetical protein 0.0579 0.3385 0.3381
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.1547 0.1516
Loa Loa (eye worm) protein kinase domain-containing protein 0.0225 0.1155 0.115
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0264 0.0228
Entamoeba histolytica protein kinase, putative 0.0084 0.026 0.157
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.0506 0.047
Loa Loa (eye worm) hypothetical protein 0.0151 0.0687 0.0682
Schistosoma mansoni protein kinase 0.0217 0.1104 0.1104
Schistosoma mansoni protein kinase 0.016 0.0742 0.0742
Brugia malayi Protein kinase domain containing protein 0.0117 0.0473 0.0469
Brugia malayi cell division control protein 2 homolog 0.0122 0.0506 0.0501
Toxoplasma gondii AGC kinase 0.025 0.1312 0.1294
Loa Loa (eye worm) brahma associated protein 0.1627 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0148 0.0148
Schistosoma mansoni protein kinase 0.0111 0.0436 0.0436
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0066 0.0148 0.0143
Echinococcus granulosus casein kinase I delta 0.0111 0.0436 0.0431
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.009 0.0302 0.0297
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1627 1 1
Onchocerca volvulus 0.0579 0.3385 0.3381
Trichomonas vaginalis STE family protein kinase 0.0085 0.0271 0.0234
Trypanosoma cruzi casein kinase, putative 0.0111 0.0436 0.1196
Brugia malayi MAP kinase sur-1 0.0084 0.0264 0.026
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.0015
Entamoeba histolytica protein kinase domain containing protein 0.0126 0.0529 0.3333
Schistosoma mansoni kinase 0.0308 0.1674 0.1674
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0048 0.0037 0.0007
Echinococcus multilocularis mitogen activated protein kinase 11 0.0166 0.0783 0.0778
Echinococcus multilocularis hypothetical protein 0.0067 0.0153 0.0148
Toxoplasma gondii aurora kinase 0.009 0.0302 0.0282
Onchocerca volvulus 0.034 0.188 0.1876
Trypanosoma cruzi WLM domain containing protein, putative 0.0579 0.3385 1
Plasmodium falciparum protein serine/threonine kinase-1 0.016 0.0745 0.0713
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0249 0.1305 0.13
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0066 0.0148 0.0337
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0166 0.0783 0.2232
Schistosoma mansoni titin 0.0043 0.0006 0.0006
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0126 0.0529 0.1475
Entamoeba histolytica hypothetical protein 0.0126 0.0529 0.3333
Schistosoma mansoni tyrosine kinase 0.017 0.0806 0.0806
Echinococcus granulosus expressed protein 0.0084 0.026 0.0255
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0133 0.0574 0.0554
Loa Loa (eye worm) hypothetical protein 0.0122 0.0501 0.0496
Loa Loa (eye worm) hypothetical protein 0.0579 0.3385 0.3381
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0122 0.0501 0.0501
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0085 0.0271 0.164
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.016 0.0745 0.212
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0393 0.2211 0.2206
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0142 0.0629 0.1772
Echinococcus granulosus serine:threonine protein kinase 0.0117 0.0473 0.0469
Trichomonas vaginalis STE family protein kinase 0.0087 0.028 0.0244
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1627 1 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0715 0.071
Schistosoma mansoni atypical protein kinase C 0.0288 0.155 0.155
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0085 0.0271 0.0703
Brugia malayi Protein kinase domain 0.0087 0.028 0.0275
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0145 0.0651 0.0646
Trypanosoma cruzi casein kinase, putative 0.0111 0.0436 0.1196
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.1925 0.1925
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0145 0.0651 0.0646
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0111 0.0436 0.0431
Echinococcus multilocularis mitogen activated protein kinase 11 0.0166 0.0783 0.0778
Entamoeba histolytica casein kinase, putative 0.0102 0.0377 0.2336
Echinococcus granulosus casein kinase I alpha 0.0111 0.0436 0.0431
Loa Loa (eye worm) TK/EGFR protein kinase 0.0246 0.1283 0.1278
Onchocerca volvulus 0.0201 0.1 0.0995
Schistosoma mansoni protein kinase 0.0466 0.2673 0.2673
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0377 0.2113 0.2109
Giardia lamblia Kinase, AGC PKA 0.0073 0.0191 0.1015
Onchocerca volvulus 0.0111 0.0436 0.0431
Onchocerca volvulus 0.0347 0.1925 0.192
Schistosoma mansoni serine/threonine protein kinase 0.0235 0.1217 0.1217
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1627 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0288 0.1547 0.4514
Loa Loa (eye worm) hypothetical protein 0.007 0.0173 0.0168
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0082 0.0249 0.0244
Trypanosoma brucei SNF1-related protein kinases, putative 0.0066 0.0148 0.0337
Loa Loa (eye worm) hypothetical protein 0.0297 0.1605 0.16
Echinococcus multilocularis 0.0132 0.0563 0.0558
Echinococcus multilocularis mitogen activated protein kinase 0.0084 0.0264 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0377 0.0341
Entamoeba histolytica casein kinase 1, putative 0.0111 0.0436 0.2721
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0377 0.2113 0.2109
Leishmania major hypothetical protein, conserved 0.0579 0.3385 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0062 0.0121 0.0116
Echinococcus multilocularis casein kinase I delta 0.0111 0.0436 0.0431
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0127 0.0534 0.053
Loa Loa (eye worm) thyroid receptor interactor 0.0085 0.0269 0.0263
Echinococcus granulosus serine/threonine protein kinase 0.0142 0.0629 0.0624
Brugia malayi Protein kinase c protein 2 0.0119 0.0484 0.0479
Echinococcus multilocularis myotubularin protein 13 0.0054 0.0072 0.0067
Brugia malayi SWIB/MDM2 domain containing protein 0.1627 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0644 0.0644
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0084 0.026 0.024
Entamoeba histolytica protein kinase, putative 0.0087 0.028 0.1701
Schistosoma mansoni tyrosine kinase 0.0213 0.1075 0.1075
Schistosoma mansoni hypothetical protein 0.0067 0.0153 0.0153
Plasmodium falciparum calcium-dependent protein kinase 5 0.0103 0.0382 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.1442 0.1442
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0579 0.3385 0.3372
Schistosoma mansoni zinc finger protein 0.0579 0.3385 0.3385
Onchocerca volvulus 0.007 0.0173 0.0168
Echinococcus multilocularis ring and YY1 binding protein 0.0579 0.3385 0.3382
Plasmodium falciparum calcium-dependent protein kinase 1 0.0103 0.0382 0.0348
Brugia malayi hypothetical protein 0.0122 0.0501 0.0496
Echinococcus multilocularis Diacylglycerol kinase theta 0.0046 0.002 0.0015
Echinococcus granulosus nervana 2 0.0105 0.0394 0.0389
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.026 0.026
Echinococcus multilocularis dual specificity 0.0126 0.0529 0.0524
Brugia malayi p70 ribosomal S6 kinase beta 0.025 0.1312 0.1308
Onchocerca volvulus 0.0579 0.3385 0.3381
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0073 0.0191 0.0186
Onchocerca volvulus 0.0318 0.1742 0.1737
Loa Loa (eye worm) hypothetical protein 0.0579 0.3385 0.3381
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0151 0.0685 0.068
Echinococcus granulosus Protein kinase C brain isozyme 0.0236 0.122 0.1215
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0103 0.0382 0.0377
Entamoeba histolytica casein kinase, putative 0.0111 0.0436 0.2721
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0117 0.0468 0.0432
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0579 0.3385 0.3362
Brugia malayi hypothetical protein 0.0235 0.1217 0.1212
Brugia malayi RhoGAP domain containing protein 0.0046 0.002 0.0015
Echinococcus multilocularis rho associated protein kinase 0.0347 0.1925 0.192
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0466 0.2673 0.2669
Loa Loa (eye worm) hypothetical protein 0.0151 0.0687 0.0682
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.0243 0.1455
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0144 0.0644 0.1819
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0103 0.0382 0.0377
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0073 0.0191 0.0156
Leishmania major serine/threonine-protein kinase, putative 0.0048 0.0037 0.0007
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0073 0.0191 0.0186
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Schistosoma mansoni hypothetical protein 0.0067 0.0153 0.0153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0424 0.2406 0.2402
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0044 0.0008 0.0003
Schistosoma mansoni tyrosine kinase 0.0151 0.0686 0.0686
Echinococcus granulosus cyclin dependent kinase 0.0122 0.0506 0.0501
Echinococcus multilocularis protein kinase c eta type 0.0046 0.002 0.0015
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0122 0.0506 0.0501
Echinococcus granulosus ring and YY1 binding protein 0.0579 0.3385 0.3382
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0102 0.0377 0.0372
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0133 0.0574 0.0568
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Echinococcus multilocularis serine:threonine protein kinase N2 0.0145 0.0651 0.0646
Giardia lamblia Kinase, PLK 0.0288 0.1547 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0133 0.0574 0.0568
Echinococcus multilocularis serine:threonine protein kinase 38 0.0145 0.0651 0.0646
Onchocerca volvulus Serine\/threonine kinase homolog 0.0172 0.0817 0.0812
Trypanosoma brucei cdc2-related kinase 3 0.0122 0.0506 0.1404
Echinococcus granulosus dual specificity 0.0126 0.0529 0.0524
Brugia malayi Protein kinase domain containing protein 0.0212 0.1069 0.1065
Onchocerca volvulus 0.0579 0.3385 0.3381
Plasmodium falciparum NIMA related kinase 2 0.0048 0.0037 0.0002
Giardia lamblia Kinase, STE STE20 0.0087 0.028 0.1608
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0134 0.0577 0.0544
Giardia lamblia Kinase, NEK 0.0058 0.0101 0.0422
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.014 0.014
Onchocerca volvulus 0.021 0.1055 0.105
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0084 0.026 0.0672
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0076 0.0213 0.0207
Echinococcus multilocularis mitogen activated protein kinase 14 0.0166 0.0783 0.0778
Brugia malayi Protein kinase domain containing protein 0.0122 0.0506 0.0501
Brugia malayi Serine/threonine-protein kinase SULU 0.0235 0.1217 0.1212
Giardia lamblia Kinase, CMGC MAPK 0.0084 0.0264 0.1504
Schistosoma mansoni tyrosine kinase 0.017 0.0806 0.0806
Brugia malayi casein kinase I 0.0111 0.0436 0.0431
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.017 0.0806 0.0801
Loa Loa (eye worm) hypothetical protein 0.0094 0.0323 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.1547 0.1516
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.1506 0.1506
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0133 0.0574 0.0574
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0053 0.0065 0.0065
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0122 0.0506 0.05
Schistosoma mansoni serine/threonine-protein kinase 0.0142 0.0629 0.0629
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0122 0.0501 0.1391
Schistosoma mansoni tyrosine kinase 0.0151 0.0686 0.0686
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0264 0.0264
Echinococcus granulosus NDR protein kinase 0.0145 0.0651 0.0646
Onchocerca volvulus 0.0579 0.3385 0.3381
Toxoplasma gondii casein kinase I 0.0111 0.0436 0.0416
Entamoeba histolytica protein kinase domain containing protein 0.0144 0.0644 0.4087
Echinococcus multilocularis calcium activated potassium channel 0.0096 0.0336 0.0331
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0061
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0081 0.0246 0.0211
Schistosoma mansoni protein kinase 0.0393 0.2211 0.2211
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0103 0.0382 0.0377
Echinococcus multilocularis ephrin type A receptor 4 A 0.0089 0.0293 0.0288
Echinococcus multilocularis SWI:SNF matrix associated 0.1627 1 1
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0214 0.1082 0.1078
Brugia malayi Protein kinase domain containing protein 0.0097 0.0346 0.0341
Echinococcus multilocularis dual specificity 0.0144 0.0644 0.064
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0203 0.1015 0.101
Brugia malayi serine/threonine-protein kinase 6 0.009 0.0302 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0745 0.071
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0134 0.0577 0.0572
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0066 0.0148 0.0111
Brugia malayi protein kinase C3,putative 0.0165 0.0773 0.0768
Brugia malayi Cam kinase protein 1 0.0103 0.0382 0.0377
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0151 0.0685 0.068
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0148 0.0148
Trichomonas vaginalis AGC family protein kinase 0.0154 0.0703 0.0668
Echinococcus multilocularis titin 0.0043 0.0006 0.0001
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0103 0.0382 0.0362
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.1547 0.1516
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0579 0.3385 0.3382
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0339 0.1871 0.1867
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0157 0.0726 0.0721
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0084 0.0264 0.0685
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0122 0.0501 0.0501
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.1547 0.1516
Loa Loa (eye worm) CMGC/CLK protein kinase 0.016 0.0745 0.074
Echinococcus multilocularis 0.016 0.0742 0.0737
Brugia malayi Kinase associated domain 1 family protein 0.0067 0.0153 0.0148
Loa Loa (eye worm) hypothetical protein 0.0097 0.0347 0.0341
Loa Loa (eye worm) hypothetical protein 0.0503 0.2906 0.2902
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0103 0.0382 0.0377
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0151 0.0684 0.0679
Schistosoma mansoni rap gtpase-activating protein 0.0122 0.0501 0.0501
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0066 0.0148 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0336 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0651 0.0651
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0393 0.2211 0.2207
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0574 0.0538
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0212 0.1069 0.1064
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0087 0.028 0.0275
Schistosoma mansoni tyrosine kinase 0.0053 0.0068 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.0131 0.0558 0.0522
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0336 0.0336
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0084 0.0264 0.0245
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0651 0.0616
Brugia malayi Protein kinase domain containing protein 0.0126 0.0529 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.0894 0.0894
Leishmania major protein kinase, putative 0.0048 0.0037 0.0007
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0044 0.0008 0.0003
Echinococcus granulosus tumor protein p63 0.1372 0.8389 0.8388
Loa Loa (eye worm) hypothetical protein 0.0197 0.0975 0.097
Schistosoma mansoni serine/threonine kinase 0.0145 0.0651 0.0651
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0103 0.0382 0.0377
Loa Loa (eye worm) AUR protein kinase 0.009 0.0302 0.0297
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0579 0.3385 0.3382
Trypanosoma cruzi p21-activated kinase 3, putative 0.0053 0.0064 0.0087
Brugia malayi Protein kinase domain containing protein 0.0084 0.026 0.0255
Echinococcus multilocularis serine:threonine protein kinase N2 0.0141 0.0624 0.062
Trypanosoma brucei hypothetical protein, conserved 0.0579 0.3385 1
Entamoeba histolytica protein kinase domain containing protein 0.0214 0.1082 0.6953
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.009 0.0302 0.1846
Echinococcus granulosus cyclin dependent kinase 1 0.0122 0.0506 0.0501
Giardia lamblia Kinase, CMGC CK2 0.0102 0.0377 0.225
Entamoeba histolytica PH domain containing protein kinase, putative 0.0142 0.0629 0.3984
Trichomonas vaginalis STE family protein kinase 0.0087 0.028 0.0244
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0073 0.0191 0.0186
Echinococcus multilocularis calcium dependent protein kinase 0.0074 0.02 0.0195
Plasmodium falciparum casein kinase 2, alpha subunit 0.0102 0.0377 0.0343
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0172 0.0817 0.0812
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.016 0.0745 0.212
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0052 0.0064 0.0064
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0102 0.0377 0.0341
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0055 0.0079 0.0074
Entamoeba histolytica protein kinase domain containing protein 0.0133 0.0574 0.3622
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0121 0.0494 0.0489
Loa Loa (eye worm) AGC/PKA protein kinase 0.0073 0.0191 0.0185
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0066 0.0148 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.1627 1 1
Leishmania major casein kinase, putative 0.0111 0.0436 0.1196
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0126 0.0529 0.1475
Plasmodium vivax calcium-dependent protein kinase, putative 0.0103 0.0382 0.0346
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.0644 0.0609
Loa Loa (eye worm) hypothetical protein 0.0156 0.0715 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0947 0.0947
Schistosoma mansoni cellular tumor antigen P53 0.0201 0.1 0.1
Schistosoma mansoni cell adhesion molecule 0.0067 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0117 0.0473 0.0468
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0574 0.0538
Echinococcus multilocularis casein kinase I alpha 0.0111 0.0436 0.0431
Echinococcus granulosus roundabout 2 0.0079 0.0229 0.0224
Brugia malayi ephrin receptor 1 precursor 0.0052 0.006 0.0055
Echinococcus multilocularis serine:threonine protein kinase 0.0117 0.0473 0.0469
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.0015
Echinococcus granulosus insulin receptor 0.0213 0.1075 0.107
Echinococcus granulosus zinc finger protein Ran binding 0.0579 0.3385 0.3382
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0579 0.3385 0.3381
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0212 0.1069 0.1064
Giardia lamblia Kinase, CMGC CDK 0.0122 0.0506 0.3101
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0377 0.0341
Giardia lamblia Kinase, CMGC CLK 0.016 0.0745 0.4688
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0082 0.0077
Entamoeba histolytica p21-activated kinase 0.0095 0.0332 0.2042
Echinococcus multilocularis cyclin dependent kinase 5 0.0122 0.0506 0.0501
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0236 0.122 0.122
Echinococcus granulosus fibroblast growth factor receptor 4 0.0127 0.0534 0.053
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0103 0.0382 0.0346
Echinococcus granulosus activin receptor type 0.0048 0.0035 0.003
Giardia lamblia Kinase, AGC PKA 0.0134 0.0577 0.3572
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0122 0.0501 0.1391
Loa Loa (eye worm) AGC/NDR protein kinase 0.0145 0.0651 0.0646
Schistosoma mansoni protein kinase C 0.0047 0.0029 0.0029
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0133 0.0574 0.1607
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0191 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0506 0.0506
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0066 0.0148 0.0143
Loa Loa (eye worm) AUR protein kinase 0.009 0.0302 0.0297
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.023 0.1185 0.1181
Echinococcus granulosus epidermal growth factor receptor 0.0246 0.1283 0.1278
Echinococcus granulosus rho-associated protein kinase 1 0.0347 0.1925 0.192
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0073 0.0191 0.0154
Echinococcus granulosus protein kinase c iota type 0.0281 0.1508 0.1504
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0103 0.0382 0.0377
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0053 0.0064 0.0059
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0172 0.0817 0.0812
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0184 0.0894 0.0889
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0172 0.0815 0.081
Echinococcus multilocularis Rac GTPase activating protein 1 0.0046 0.002 0.0015
Schistosoma mansoni protein kinase 0.0466 0.2673 0.2673
Plasmodium vivax casein kinase 1, putative 0.0111 0.0436 0.04
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0466 0.2673 0.2669
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.016 0.0745 0.212
Echinococcus multilocularis protein kinase c iota type 0.0281 0.1508 0.1504
Schistosoma mansoni brg-1 associated factor 0.1627 1 1
Trypanosoma cruzi casein kinase II, putative 0.0102 0.0377 0.1021
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0191 0.0154
Giardia lamblia Kinase, AGC AKT 0.0121 0.0494 0.3022
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.016 0.0745 0.212
Schistosoma mansoni serine/threonine protein kinase 0.0513 0.2969 0.2969
Trypanosoma brucei hypothetical protein, conserved 0.0579 0.3385 1
Entamoeba histolytica protein kinase domain containing protein 0.0133 0.0574 0.3622
Echinococcus granulosus raf serine:threonine protein kinase 0.0065 0.014 0.0135
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0073 0.0191 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.1542 0.1542
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0191 0.0191
Leishmania major protein kinase A catalytic subunit 0.0073 0.0191 0.0464
Entamoeba histolytica protein kinase, putative 0.0259 0.1364 0.8801
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0084 0.026 0.0255
Echinococcus granulosus N chimaerin 0.0052 0.0064 0.0059
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0281 0.1506 0.1501
Echinococcus granulosus casein kinase I alpha 0.0111 0.0436 0.0431
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.1547 0.1516
Echinococcus granulosus titin 0.0043 0.0006 0.0001
Trypanosoma cruzi casein kinase, putative 0.0111 0.0436 0.1196
Schistosoma mansoni serine/threonine protein kinase 0.0423 0.2399 0.2399
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0214 0.1082 0.1077
Brugia malayi C1-like domain containing protein 0.023 0.1185 0.1181
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0103 0.0382 0.0346
Brugia malayi Protein kinase domain containing protein 0.102 0.6166 0.6164
Leishmania major hypothetical protein, conserved 0.0579 0.3385 1
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0082 0.0249 0.0244
Echinococcus multilocularis cyclin dependent kinase 1 0.0122 0.0506 0.0501
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.0473 0.0438
Plasmodium falciparum serine/threonine protein kinase 0.0084 0.026 0.0226
Plasmodium falciparum NIMA related kinase 1 0.0141 0.0625 0.0592
Entamoeba histolytica protein kinase, putative 0.0084 0.026 0.157
Echinococcus granulosus serine:threonine protein kinase N2 0.0141 0.0624 0.062
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0253 0.1328 0.1323
Echinococcus granulosus defective proboscis extension response 0.0053 0.0065 0.006
Trichomonas vaginalis AGC family protein kinase 0.009 0.0302 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0236 0.122 0.122
Trypanosoma brucei protein kinase, putative 0.0084 0.0264 0.0685
Leishmania major protein kinase A catalytic subunit isoform 1 0.0073 0.0191 0.0464
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0393 0.2211 0.2207
Brugia malayi Doublecortin family protein 0.0157 0.0726 0.0721
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.1305 0.1305
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.016 0.0745 0.212
Toxoplasma gondii histone kinase SNF1, putative 0.0066 0.0148 0.0128
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0087 0.028 0.0275
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0172 0.0817 0.0812
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.1229 0.1229
Schistosoma mansoni nephrin 0.0067 0.0156 0.0156
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0046 0.002 0.0015
Entamoeba histolytica protein kinase, putative 0.0063 0.0131 0.0724
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1627 1 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0073 0.0191 0.0186
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0074 0.0197 0.0191
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0085 0.0271 0.0703
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.025 0.1312 0.1307
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0052 0.0064 0.0064
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0237 0.1229 0.1225
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0073 0.0191 0.0464
Loa Loa (eye worm) hypothetical protein 0.0122 0.0501 0.0496
Giardia lamblia Kinase, CK1 Casein kinase 0.0111 0.0436 0.2639
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0166 0.0783 0.0778
Echinococcus multilocularis protein kinase shaggy 0.0133 0.0574 0.0569
Echinococcus granulosus protein kinase c eta type 0.0046 0.002 0.0015
Brugia malayi Protein kinase domain containing protein 0.0204 0.1021 0.1016
Loa Loa (eye worm) hypothetical protein 0.013 0.0551 0.0546
Echinococcus granulosus titin 0.0043 0.0006 0.0001
Entamoeba histolytica PH domain containing protein kinase, putative 0.0142 0.0629 0.3984
Echinococcus granulosus calcium activated potassium channel 0.0096 0.0336 0.0331
Toxoplasma gondii NEK kinase 0.0048 0.0037 0.0017
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0127 0.0534 0.053
Giardia lamblia Kinase, CMGC SRPK 0.0084 0.026 0.1475
Brugia malayi Ras association domain family 1 isoform A 0.0046 0.002 0.0015
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0103 0.0382 0.0377
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0084 0.026 0.0672
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0246 0.1285 0.128
Loa Loa (eye worm) TK/ALK protein kinase 0.0277 0.1479 0.1474
Brugia malayi casein kinase 1, delta 0.0111 0.0436 0.0431
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0037 0.0037
Echinococcus granulosus serine:threonine kinase SAD 1 0.0066 0.0148 0.0143
Brugia malayi phosphoinositide-dependent protein kinase I 0.0082 0.0249 0.0244
Entamoeba histolytica protein kinase domain containing protein 0.009 0.0302 0.1846
Onchocerca volvulus 0.0047 0.0029 0.0024
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0579 0.3385 0.3381
Plasmodium vivax tyrosine kinase-like protein, putative 0.0081 0.0246 0.0209
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0122 0.0506 0.1404
Entamoeba histolytica protein kinase, putative 0.0126 0.0529 0.3333
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0145 0.0651 0.0646
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0048 0.0037 0.0007
Echinococcus multilocularis N chimaerin 0.0052 0.0064 0.0059
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0103 0.0382 0.0377
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0166 0.0783 0.2232
Schistosoma mansoni protein kinase C mu 0.0046 0.002 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.0644 0.0609
Entamoeba histolytica protein kinase, putative 0.0071 0.0183 0.1065
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0273 0.1455 0.145
Entamoeba histolytica protein kinase , putative 0.009 0.0302 0.1846
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0133 0.0574 0.0569
Schistosoma mansoni hypothetical protein 0.1627 1 1
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0082 0.0249 0.0244
Schistosoma mansoni protein kinase 0.0063 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1323
Brugia malayi Fibronectin type III domain containing protein 0.0055 0.0082 0.0077
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0532 0.3088 0.3085
Brugia malayi Variant SH3 domain containing protein 0.0052 0.0064 0.0059
Giardia lamblia Kinase, STE STE20 0.0085 0.0271 0.1546
Echinococcus multilocularis nervana 2 0.0105 0.0394 0.0389
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0048 0.0037 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0259 0.1364 0.1332
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0126 0.0529 0.1475
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Plasmodium falciparum calcium-dependent protein kinase 4 0.0103 0.0382 0.0348
Leishmania major protein kinase A catalytic subunit isoform 2 0.0073 0.0191 0.0464
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0103 0.0382 0.0362
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0579 0.3385 1
Trichomonas vaginalis AGC family protein kinase 0.0259 0.1364 0.1332
Loa Loa (eye worm) RasGEF domain-containing protein 0.0046 0.002 0.0015
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0048 0.0037 0.0007
Echinococcus multilocularis PAK box P21 Rho binding 0.0063 0.0131 0.0126
Loa Loa (eye worm) AGC/AKT protein kinase 0.0259 0.1364 0.1359
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1627 1 1
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0423 0.2399 0.2396
Echinococcus granulosus hypothetical protein 0.0132 0.0563 0.0558
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0053 0.0064 0.0059
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0111 0.0436 0.0431
Echinococcus multilocularis serine:threonine protein kinase 0.0117 0.0473 0.0469
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0579 0.3385 0.3382
Plasmodium falciparum serine/threonine protein kinase, putative 0.009 0.0302 0.0268
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0423 0.2399 0.2395
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0073 0.0191 0.0186
Echinococcus multilocularis protein kinase c epsilon type 0.0192 0.0947 0.0942
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0046 0.002 0.0015
Plasmodium vivax serine/threonine protein kinase, putative 0.0084 0.026 0.0224
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0087 0.028 0.0275
Toxoplasma gondii AGC kinase 0.0073 0.0191 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.1155 0.1155
Loa Loa (eye worm) hypothetical protein 0.0089 0.0293 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.1547 0.1547
Plasmodium vivax glycogen synthase kinase 3, putative 0.0133 0.0574 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0377 0.0341
Toxoplasma gondii NEK kinase 0.0048 0.0037 0.0017
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0103 0.0382 0.0377
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0579 0.3385 1
Schistosoma mansoni rac gtpase activating protein 0.0046 0.002 0.002
Onchocerca volvulus 0.0133 0.0574 0.0568
Echinococcus multilocularis epidermal growth factor receptor 0.017 0.0806 0.0801
Trypanosoma brucei casein kinase I, isoform 2 0.0111 0.0436 0.1196
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0103 0.0382 0.0346
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0377 0.2113 0.2109
Loa Loa (eye worm) hypothetical protein 0.0122 0.0501 0.0496
Echinococcus multilocularis Glutaredoxin protein 5 0.0105 0.0394 0.0389
Echinococcus multilocularis casein kinase i 0.0111 0.0436 0.0431
Onchocerca volvulus 0.0151 0.0687 0.0682
Schistosoma mansoni unc-13 (munc13) 0.0047 0.0029 0.0029
Brugia malayi YY1-associated factor 2 0.0579 0.3385 0.3382
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0166 0.0783 0.2232
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0237 0.1229 0.1225
Entamoeba histolytica protein kinase, putative 0.0259 0.1364 0.8801
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0073 0.0191 0.0464
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0424 0.2406 0.2402
Leishmania major hypothetical protein, conserved 0.0579 0.3385 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0035 0.0097
Entamoeba histolytica protein kinase, putative 0.0133 0.0574 0.3622
Trypanosoma brucei rac serine-threonine kinase, putative 0.0259 0.1364 0.3967
Echinococcus multilocularis zinc finger protein Ran binding 0.0579 0.3385 0.3382
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0579 0.3385 1
Trichomonas vaginalis CAMK family protein kinase 0.0131 0.0558 0.0522
Echinococcus multilocularis casein kinase I alpha 0.0111 0.0436 0.0431
Echinococcus granulosus unc 13 munc13 0.0047 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.0047 0.0029 0.0024
Plasmodium falciparum casein kinase 1 0.0111 0.0436 0.0402
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0235 0.1217 0.1212
Trichomonas vaginalis AGC family protein kinase 0.0259 0.1364 0.1332
Loa Loa (eye worm) raf kinase 0.0046 0.002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0097 0.0347 0.0341
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0082 0.0249 0.0244
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0214 0.1082 0.1078
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0192 0.0947 0.0942
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0148 0.0148
Entamoeba histolytica protein kinase, putative 0.009 0.0302 0.1846
Trypanosoma brucei protein kinase, putative 0.0133 0.0574 0.1607
Loa Loa (eye worm) AUR protein kinase 0.009 0.0302 0.0297
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0235 0.1217 0.1212
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.016 0.0745 0.0726
Echinococcus multilocularis SWI:SNF matrix associated 0.1627 1 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0073 0.0191 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0336 0.0336
Plasmodium vivax serine/threonine protein kinase 6, putative 0.009 0.0302 0.0266
Loa Loa (eye worm) hypothetical protein 0.0066 0.0148 0.0143
Echinococcus granulosus ephrin type A receptor 4 A 0.0089 0.0293 0.0288
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0111 0.0436 0.1196
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.1547 0.1516
Echinococcus granulosus casein kinase i 0.0111 0.0436 0.0431
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0579 0.3385 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0134 0.0577 0.1617
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0212 0.1069 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0098 0.006
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0122 0.0506 0.1404
Giardia lamblia Kinase, CMGC CDK 0.0122 0.0506 0.3101
Entamoeba histolytica protein kinase, putative 0.0126 0.0529 0.3333
Giardia lamblia Aurora kinase 0.009 0.0302 0.1754
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0073 0.0191 0.0464
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0651 0.0616
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.102 0.6166 0.6164
Giardia lamblia Kinase, NEK 0.0058 0.0101 0.0422
Trichomonas vaginalis STE family protein kinase 0.0087 0.028 0.0244
Brugia malayi Protein kinase domain containing protein 0.0225 0.1155 0.1151
Brugia malayi putative serine/threonine kinase SADA gamma 0.0066 0.0148 0.0143
Echinococcus multilocularis Immunoglobulin 0.0053 0.0065 0.006
Giardia lamblia Kinase, CAMK CAMKL 0.0066 0.0148 0.0734
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0837 0.0837
Plasmodium vivax serine/threonine kinase-1, putative 0.016 0.0745 0.071
Trypanosoma cruzi cdc2-related kinase 1 0.0122 0.0506 0.1404
Echinococcus multilocularis casein kinase ii subunit alpha 0.0102 0.0377 0.0372
Loa Loa (eye worm) hypothetical protein 0.0055 0.0082 0.0076
Brugia malayi RhoGEF domain containing protein 0.0046 0.002 0.0015
Echinococcus granulosus mitogen activated protein kinase 11 0.0166 0.0783 0.0778
Echinococcus granulosus protein kinase 0.016 0.0742 0.0737
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0133 0.0574 0.1607
Echinococcus multilocularis rac serine:threonine kinase 0.0142 0.0629 0.0624
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0052 0.0064 0.0059
Echinococcus granulosus protein kinase C gamma type 0.019 0.0932 0.0928
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0073 0.0191 0.0464
Brugia malayi Protein kinase domain containing protein 0.0082 0.0249 0.0244
Schistosoma mansoni netrin receptor unc5 0.0043 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0111 0.0111
Echinococcus granulosus Rac GTPase activating protein 1 0.0046 0.002 0.0015
Echinococcus granulosus serine:threonine protein kinase 3 0.0273 0.1455 0.1451
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0377 0.0341
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0178 0.0856 0.0851
Brugia malayi Protein kinase domain containing protein 0.0145 0.0651 0.0646
Entamoeba histolytica cell division protein kinase 2, putative 0.0122 0.0506 0.3178
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.0015
Echinococcus multilocularis unc 13 (munc13) 0.0047 0.0029 0.0024
Brugia malayi diacylglycerol kinase 0.0046 0.002 0.0015
Brugia malayi Protein kinase domain containing protein 0.0096 0.0336 0.0331
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0122 0.0501 0.0496
Schistosoma mansoni protein kinase 0.009 0.0302 0.0302
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0184 0.0894 0.0889
Brugia malayi Protein kinase domain containing protein 0.0393 0.2211 0.2207
Trypanosoma cruzi hypothetical protein, conserved 0.0579 0.3385 1
Trichomonas vaginalis AGC family protein kinase 0.0259 0.1364 0.1332
Entamoeba histolytica protein kinase, putative 0.0145 0.0651 0.4128
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0264 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0382 0.0382
Toxoplasma gondii NEK kinase 0.0048 0.0037 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0579 0.3385 0.3382
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.0894 0.0894
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0084 0.0264 0.0685
Brugia malayi Hr1 repeat family protein 0.0287 0.1542 0.1538
Echinococcus multilocularis serine:threonine protein kinase N2 0.0287 0.1542 0.1538
Echinococcus multilocularis insulin receptor 0.0213 0.1075 0.107
Trypanosoma cruzi casein kinase, putative 0.0111 0.0436 0.1196
Brugia malayi Protein kinase domain containing protein 0.0213 0.1075 0.107
Echinococcus granulosus Immunoglobulin 0.0053 0.0065 0.006
Echinococcus multilocularis serine:threonine protein kinase 3 0.0273 0.1455 0.1451
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0144 0.0644 0.0625
Trichomonas vaginalis STE family protein kinase 0.0087 0.028 0.0244
Echinococcus granulosus serine:threonine protein kinase N2 0.0287 0.1542 0.1538
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0148 0.0148
Brugia malayi Temporarily assigned gene name protein 59 0.0141 0.062 0.0615
Loa Loa (eye worm) hypothetical protein 0.0054 0.0072 0.0067
Loa Loa (eye worm) casein kinase 0.0196 0.0973 0.0968
Loa Loa (eye worm) hypothetical protein 0.0055 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.0015
Loa Loa (eye worm) TK protein kinase 0.0139 0.0608 0.0603
Toxoplasma gondii ran binding protein 0.0579 0.3385 0.3372
Schistosoma mansoni vav2 0.0061 0.0116 0.0116
Trichomonas vaginalis CK1 family protein kinase 0.0111 0.0436 0.04
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0105 0.0394 0.0389
Echinococcus granulosus Diacylglycerol kinase theta 0.0046 0.002 0.0015
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0217 0.1104 0.11
Loa Loa (eye worm) hypothetical protein 0.0132 0.0563 0.0558
Loa Loa (eye worm) TK/EPH protein kinase 0.0108 0.0414 0.0408
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0048 0.0035 0.0015
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0103 0.0382 0.1036
Echinococcus multilocularis cyclin dependent kinase 0.0122 0.0506 0.0501
Giardia lamblia Kinase, NEK 0.0141 0.0625 0.3891
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0141 0.0625 0.059
Leishmania major protein kinase, putative 0.016 0.0745 0.212
Loa Loa (eye worm) hypothetical protein 0.0151 0.0687 0.0682
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0185
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0087 0.028 0.0275
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0377 0.2113 0.2109
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0288 0.1547 0.1543
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0053 0.0064 0.0027
Brugia malayi Protein kinase domain containing protein 0.0172 0.0817 0.0812
Echinococcus granulosus casein kinase I gamma 0.0225 0.1155 0.1151
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0363 0.2023 0.2019
Loa Loa (eye worm) hypothetical protein 0.0579 0.3385 0.3381
Giardia lamblia Kinase, CMGC GSK 0.0133 0.0574 0.355
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0103 0.0382 0.0362
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0122 0.0501 0.0501
Brugia malayi RhoGAP domain containing protein 0.0052 0.0064 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.0817 0.0817
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0084 0.0264 0.0685
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0073 0.0191 0.0464
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0178 0.0856 0.0851
Schistosoma mansoni protein kinase 0.0466 0.2673 0.2673
Plasmodium falciparum serine/threonine protein kinase KIN 0.0066 0.0148 0.0113
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0141 0.0625 0.0606
Loa Loa (eye worm) hypothetical protein 0.0103 0.0382 0.0377
Echinococcus granulosus myotubularin protein 13 0.0054 0.0072 0.0067
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0096 0.0336 0.033
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0127 0.0534 0.053
Schistosoma mansoni serine/threonine protein kinase 0.0377 0.2113 0.2113
Schistosoma mansoni diacylglycerol kinase theta 0.0046 0.002 0.002
Echinococcus multilocularis aurora kinase A 0.009 0.0302 0.0297
Entamoeba histolytica protein kinase, putative 0.0144 0.0644 0.4087
Echinococcus multilocularis serine threonine protein kinase 0.019 0.0932 0.0928
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0579 0.3385 0.3382
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0087 0.028 0.0275
Brugia malayi Protein kinase domain containing protein 0.006 0.0114 0.0109
Echinococcus multilocularis neuroglian 0.0064 0.0139 0.0134
Entamoeba histolytica protein kinase 2, putative 0.0134 0.0577 0.3644
Brugia malayi brahma associated protein 60 kDa 0.1627 1 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0281 0.1506 0.1502
Echinococcus granulosus mitogen activated protein kinase 0.0084 0.0264 0.026
Echinococcus granulosus mitogen activated protein kinase 3 0.0084 0.0264 0.026
Echinococcus granulosus SWI:SNF matrix associated 0.1627 1 1
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0117 0.0473 0.0468
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0288 0.1547 0.1543
Echinococcus multilocularis nervana 2 0.0105 0.0394 0.0389
Loa Loa (eye worm) hypothetical protein 0.0201 0.1003 0.0998
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0084 0.0264 0.0685
Plasmodium vivax unspecified product 0.0102 0.0377 0.0341
Echinococcus multilocularis activin receptor type 0.0048 0.0035 0.003
Schistosoma mansoni protein kinase 0.0282 0.151 0.151
Leishmania major protein kinase, putative 0.016 0.0745 0.212
Leishmania major casein kinase II, putative 0.0102 0.0377 0.1021
Trypanosoma cruzi casein kinase, putative 0.0111 0.0436 0.1196
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0122 0.0501 0.1391
Echinococcus granulosus cyclin dependent kinase 5 0.0122 0.0506 0.0501
Trichomonas vaginalis AGC family protein kinase 0.009 0.0302 0.0266
Trichomonas vaginalis CK1 family protein kinase 0.0111 0.0436 0.04
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0066 0.0148 0.0143
Brugia malayi serine/threonine kinase 12 0.009 0.0302 0.0297
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0066 0.0148 0.0337
Trypanosoma cruzi NIMA-related kinase, putative 0.0048 0.0037 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0745 0.0745
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0151 0.0684 0.0679
Brugia malayi Pleckstrin Homology Domain 0.0054 0.0072 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.1069 0.1069
Echinococcus multilocularis dual specificity 0.0144 0.0644 0.064
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.0243 0.1455
Brugia malayi Protein kinase domain containing protein 0.0277 0.148 0.1475
Trypanosoma cruzi polo-like protein kinase, putative 0.0288 0.1547 0.4514
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0066 0.0148 0.0337
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0249 0.0212
Plasmodium vivax hypothetical protein, conserved 0.1627 1 1
Schistosoma mansoni tyrosine kinase 0.0151 0.0686 0.0686
Brugia malayi serine/threonine protein kinase 6 0.009 0.0302 0.0297
Echinococcus granulosus serine threonine protein kinase nrc 0.0134 0.0577 0.0572
Schistosoma mansoni hypothetical protein 0.0046 0.002 0.002
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0249 0.0212
Loa Loa (eye worm) hypothetical protein 0.0053 0.0065 0.006
Schistosoma mansoni tyrosine kinase 0.0171 0.0813 0.0813
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0249 0.0212
Trypanosoma cruzi aurora B kinase, putative 0.009 0.0302 0.0797
Giardia lamblia Kinase, CMGC DYRK 0.0144 0.0644 0.402
Trypanosoma brucei aurora B kinase 0.009 0.0302 0.0797
Schistosoma mansoni diacylglycerol kinase theta 0.0046 0.002 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0064 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0066 0.0148 0.0337
Echinococcus multilocularis SWI:SNF matrix associated 0.1627 1 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0073 0.0191 0.0171
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0048 0.0037 0.0007
Onchocerca volvulus 0.0201 0.1003 0.0998
Entamoeba histolytica serine/threonine protein kinase, putative 0.0288 0.1547 1
Brugia malayi Temporarily assigned gene name protein 59 0.0122 0.0501 0.0496
Echinococcus multilocularis casein kinase I alpha 0.0111 0.0436 0.0431
Loa Loa (eye worm) hypothetical protein 0.0067 0.0153 0.0148
Schistosoma mansoni serine/threonine kinase 0.0096 0.0336 0.0336
Brugia malayi serine/threonine-protein kinase plk-2 0.0288 0.1547 0.1543
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.016 0.0745 0.212
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0579 0.3385 1
Echinococcus multilocularis casein kinase I gamma 0.0225 0.1155 0.1151
Toxoplasma gondii CMGC kinase, CK2 family 0.0102 0.0377 0.0357
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.0506 0.047
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0185 0.0898 0.0893
Loa Loa (eye worm) hypothetical protein 0.0064 0.0139 0.0133
Plasmodium falciparum glycogen synthase kinase 3 0.0133 0.0574 0.054
Leishmania major hypothetical protein, conserved 0.0579 0.3385 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0081 0.0246 0.0226
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0482 0.2773 0.2769
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0579 0.3385 1
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.0506 0.0506
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.009 0.0302 0.1846
Schistosoma mansoni tyrosine kinase 0.0246 0.1283 0.1283
Plasmodium falciparum calcium-dependent protein kinase 3 0.0103 0.0382 0.0348
Echinococcus granulosus Glutaredoxin protein 5 0.0105 0.0394 0.0389
Trypanosoma brucei polo-like protein kinase 0.0288 0.1547 0.4514
Trichomonas vaginalis AGC family protein kinase 0.009 0.0302 0.0266
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0122 0.0501 0.0496
Trypanosoma cruzi hypothetical protein, conserved 0.0579 0.3385 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0166 0.0783 0.0778
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0473 0.2716 0.2712
Trypanosoma brucei Casein kinase II 0.0102 0.0377 0.1021
Echinococcus multilocularis myosin iiia 0.0085 0.0271 0.0266
Echinococcus granulosus Zinc finger RanBP2 type 0.0579 0.3385 0.3382
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0145 0.0651 0.0646
Leishmania major protein kinase, putative 0.0103 0.0382 0.1036
Leishmania major protein kinase, putative 0.009 0.0302 0.0797
Trichomonas vaginalis AGC family protein kinase 0.0259 0.1364 0.1332
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0214 0.1082 0.1078
Trypanosoma brucei cdc2-related kinase 1 0.0122 0.0506 0.1404
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0134 0.0577 0.0572
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0053 0.0065 0.006
Brugia malayi map kinase activated protein kinase protein 2 0.0423 0.2399 0.2396
Echinococcus multilocularis cyclin dependent kinase 1 0.0122 0.0506 0.0501
Trichomonas vaginalis AGC family protein kinase 0.009 0.0302 0.0266
Schistosoma mansoni tyrosine kinase 0.0213 0.1075 0.1075
Brugia malayi Protein kinase domain containing protein 0.0145 0.0651 0.0646
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0264 0.0228
Echinococcus multilocularis dual specificity protein kinase clk2 0.016 0.0745 0.0741
Echinococcus granulosus dual specificity 0.0144 0.0644 0.064
Schistosoma mansoni hypothetical protein 0.0579 0.3385 0.3385
Onchocerca volvulus 0.0122 0.0501 0.0496
Entamoeba histolytica protein kinase, putative 0.0104 0.0391 0.2426
Schistosoma mansoni tyrosine kinase 0.0127 0.0534 0.0534
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0134 0.0577 0.0541
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0436 0.0436
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0006 0.0001
Entamoeba histolytica serine/threonine protein kinase, putative 0.0048 0.0037 0.0112
Leishmania major protein kinase, putative 0.0085 0.0271 0.0703
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0608 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0336 0.0336
Chlamydia trachomatis DNA topoisomerase I 0.1627 1 0.5
Entamoeba histolytica protein kinase, putative 0.009 0.0302 0.1846
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0144 0.0644 0.0639
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0377 0.0341
Loa Loa (eye worm) hypothetical protein 0.0076 0.0213 0.0207
Plasmodium vivax protein kinase Crk2 0.0122 0.0506 0.047
Echinococcus multilocularis mitogen activated protein kinase 14 0.0166 0.0783 0.0778
Loa Loa (eye worm) hypothetical protein 0.0058 0.0098 0.0092
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0184 0.0894 0.0889
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0084 0.0264 0.0259
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0288 0.1547 0.4514
Echinococcus multilocularis 0.0069 0.017 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0249 0.0249
Toxoplasma gondii AGC kinase 0.0073 0.0191 0.0171
Schistosoma mansoni protein kinase 0.0087 0.028 0.028
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0237 0.1229 0.1224
Schistosoma mansoni RNA binding protein 0.0579 0.3385 0.3385
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0105 0.0394 0.0389
Trichomonas vaginalis STE family protein kinase 0.0141 0.0625 0.059
Schistosoma mansoni vam6/vps39 related 0.0122 0.0501 0.0501
Brugia malayi hypothetical protein 0.0055 0.0082 0.0077
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0579 0.3385 0.3382
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0377 0.2113 0.2109
Echinococcus granulosus casein kinase I alpha 0.0111 0.0436 0.0431
Onchocerca volvulus 0.1627 1 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1627 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.0506 0.047
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0083 0.0253 0.0651
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0579 0.3385 1
Onchocerca volvulus 0.0083 0.0253 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.1082 0.1082
Giardia lamblia Kinase, CMGC GSK 0.0133 0.0574 0.355
Loa Loa (eye worm) hypothetical protein 0.0227 0.1164 0.116
Echinococcus granulosus serine:threonine protein kinase 12 B 0.009 0.0302 0.0297
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0288 0.1547 0.1543
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0085 0.0271 0.164
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0053 0.0064 0.0087
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.0644 0.0609
Echinococcus granulosus calcium dependent protein kinase 0.0074 0.02 0.0195
Loa Loa (eye worm) TK/INSR protein kinase 0.0213 0.1075 0.107
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0579 0.3385 0.3382
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Trichomonas vaginalis STE family protein kinase 0.0063 0.0131 0.0094
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.0644 0.0609
Loa Loa (eye worm) hypothetical protein 0.0201 0.1 0.0995
Brugia malayi Protein kinase domain containing protein 0.0482 0.2773 0.277
Echinococcus multilocularis raf serine:threonine protein kinase 0.0065 0.014 0.0135
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0235 0.1217 0.1212
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0047 0.0029 0.0024
Entamoeba histolytica protein kinase, putative 0.025 0.1312 0.846
Plasmodium falciparum protein kinase 5 0.0122 0.0506 0.0472
Brugia malayi Protein kinase domain containing protein 0.0377 0.2113 0.2109
Trypanosoma brucei NIMA-related protein kinase 0.0048 0.0037 0.0007
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0053 0.0065 0.0065
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0377 0.0341
Plasmodium falciparum NIMA related kinase 4 0.0048 0.0037 0.0002
Chlamydia trachomatis SWIB complex protein 0.1627 1 0.5
Onchocerca volvulus 0.0156 0.0715 0.071
Leishmania major hypothetical protein, conserved 0.0579 0.3385 1
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0184 0.0894 0.0889
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0217 0.1104 0.11
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.016 0.0742 0.0737
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0236 0.122 0.1215
Echinococcus granulosus casein kinase I delta 0.0111 0.0436 0.0431
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.1547 0.1516
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0144 0.0644 0.1819
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0264 0.0228
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0087 0.028 0.0275
Brugia malayi diacylglycerol kinase 0.0046 0.002 0.0015
Echinococcus multilocularis casein kinase I delta 0.0111 0.0436 0.0431
Schistosoma mansoni protein kinase C mu 0.023 0.1185 0.1185
Echinococcus granulosus dual specificity 0.0144 0.0644 0.064
Echinococcus granulosus casein kinase ii subunit alpha 0.0102 0.0377 0.0372
Echinococcus granulosus aurora kinase A 0.009 0.0302 0.0297
Loa Loa (eye worm) hypothetical protein 0.021 0.1055 0.105
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Entamoeba histolytica protein kinase, putative 0.0082 0.0249 0.1497
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.1305 0.1305
Trypanosoma cruzi cdc2-related kinase 3 0.0122 0.0506 0.1404
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0529 0.0529
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.009 0.0302 0.1846
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0126 0.0529 0.0524
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0215 0.1091 0.1087
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0148 0.0111
Echinococcus multilocularis roundabout 2 0.0079 0.0229 0.0224
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0144 0.0644 0.064
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0084 0.0264 0.0685
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0423 0.2399 0.2396
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0084 0.026 0.0672
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0122 0.0506 0.05
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0133 0.0574 0.0569
Brugia malayi P38 map kinase family protein 2 0.0166 0.0783 0.0778
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0073 0.0191 0.0464
Echinococcus granulosus Vam6:Vps39 protein 0.0122 0.0501 0.0496
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0126 0.0529 0.1475
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.0015
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0066 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0055 0.0082 0.0076

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.