Detailed information for compound 177925

Basic information

Technical information
  • TDR Targets ID: 177925
  • Name: 4-decoxy-N-(7-methoxy-4-oxo-2,3-dihydrochrome n-8-yl)benzamide
  • MW: 453.571 | Formula: C27H35NO5
  • H donors: 1 H acceptors: 2 LogP: 6.65 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCOc1ccc(cc1)C(=O)Nc1c(OC)ccc2c1OCCC2=O
  • InChi: 1S/C27H35NO5/c1-3-4-5-6-7-8-9-10-18-32-21-13-11-20(12-14-21)27(30)28-25-24(31-2)16-15-22-23(29)17-19-33-26(22)25/h11-16H,3-10,17-19H2,1-2H3,(H,28,30)
  • InChiKey: UFVCJFSEGYZIQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-decoxy-N-(7-methoxy-4-oxo-chroman-8-yl)benzamide
  • 4-decoxy-N-(7-methoxy-4-oxo-3,4-dihydro-2H-1-benzopyran-8-yl)benzamide
  • 4-decoxy-N-(4-keto-7-methoxy-chroman-8-yl)benzamide
  • 4-decoxy-N-(7-methoxy-4-oxochroman-8-yl)benzamide
  • 4-decoxy-N-(7-methoxy-4-oxo-8-chromanyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.4446 0.9066 1
Schistosoma mansoni cytochrome P450 0.0032 0.0031 0.0032
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0031 0.003
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0308 0.0596 0.0611
Brugia malayi SWIRM domain containing protein 0.005 0.0068 0.0069
Echinococcus granulosus glutamate receptor ionotropic kainate 0.002 0.0006 0.0006
Leishmania major cytochrome p450-like protein 0.0041 0.0049 0.0049
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0308 0.0596 0.0611
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0181 0.0185
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4774 0.9738 1
Plasmodium vivax hypothetical protein, conserved 0.0456 0.09 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0038 0.0039
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0308 0.0596 0.0612
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.013 0.0232 0.0238
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0903 0.1814 0.1863
Echinococcus multilocularis 0.0032 0.0031 0.0032
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.013 0.0232 0.0238
Mycobacterium ulcerans beta-lactamase 0.0035 0.0038 0.0037
Echinococcus multilocularis geminin 0.0352 0.0686 0.0704
Schistosoma mansoni immunophilin 0.0058 0.0084 0.0086
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0069 0.0069
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0218 0.0224
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0031 0.003
Entamoeba histolytica hypothetical protein 0.005 0.0068 0.0035
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0903 0.1814 0.1861
Entamoeba histolytica hypothetical protein 0.0308 0.0596 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.4774 0.9738 1
Echinococcus multilocularis lamin dm0 0.0027 0.0021 0.0022
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0308 0.0596 0.0612
Onchocerca volvulus 0.0095 0.0161 0.0819
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0058 0.0084 0.0052
Plasmodium falciparum amino acid transporter, putative 0.013 0.0232 0.256
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0308 0.0596 0.0611
Trypanosoma cruzi UDP-galactopyranose mutase 0.0456 0.09 0.0923
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0595 0.1183 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0698 0.1395 0.1431
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0202 0.0221
Mycobacterium leprae Probable lipase LipE 0.0035 0.0038 0.0079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0029 0.0038
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4774 0.9738 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0031 0.003
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.013 0.0232 0.0238
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0903 0.1814 0.1863
Onchocerca volvulus 0.024 0.0457 0.2331
Brugia malayi cytochrome P450 0.0032 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0926 0.186 0.191
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0308 0.0596 0.0612
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0308 0.0596 0.0611
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0031 0.0033
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0308 0.0596 0.0611
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1601 0.3243 0.3329
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0057 0.0058
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.013 0.0232 0.0238
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0031 0.003
Trichomonas vaginalis rotamase, putative 0.0033 0.0033 0.0033
Schistosoma mansoni amine oxidase 0.0456 0.09 0.0924
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0429 0.0472
Schistosoma mansoni intermediate filament proteins 0.0027 0.0021 0.0022
Schistosoma mansoni glutamate receptor kainate 0.0041 0.0049 0.005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0001 0.0002
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.005 0.0068 0.0069
Echinococcus granulosus serotonin transporter 0.0765 0.1532 0.1573
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0308 0.0596 0.0612
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0041 0.0049 0.005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0084 0.0083
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0308 0.0596 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0308 0.0596 0.0612
Brugia malayi hypothetical protein 0.013 0.0232 0.0238
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.005 0.0068 0.0069
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.013 0.0232 0.0238
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.013 0.0232 0.0238
Schistosoma mansoni glutamate receptor NMDA 0.0041 0.0049 0.005
Loa Loa (eye worm) hypothetical protein 0.013 0.0232 0.0238
Plasmodium vivax hypothetical protein, conserved 0.0308 0.0596 0.6618
Leishmania major trypanothione reductase 0.0051 0.0069 0.0069
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.013 0.0232 0.0238
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0398 0.0409
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4774 0.9738 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0456 0.09 1
Plasmodium vivax SET domain protein, putative 0.0031 0.0029 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0596 0.0611
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0031 0.003
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0058 0.0084 0.0052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0038 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.1601 0.3243 0.3329
Loa Loa (eye worm) hypothetical protein 0.0456 0.09 0.0924
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0029 0.003
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0308 0.0596 0.0611
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0058 0.0084 0.0537
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0161 0.0165
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0069 0.0753
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0029 0.003
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0456 0.09 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0045 0.0057 0.0058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0038 0.0037
Echinococcus granulosus glutamate receptor 2 0.0025 0.0016 0.0017
Brugia malayi Thioredoxin reductase 0.0051 0.0069 0.0071
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0308 0.0596 0.0612
Echinococcus granulosus uncharacterized sodium dependent transporter 0.013 0.0232 0.0238
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0903 0.1814 0.1835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0029 0.003
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.013 0.0232 0.0238
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1601 0.3243 0.3329
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0084 0.0086
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.013 0.0232 0.0238
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0035 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0031 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.2853 0.5805 0.596
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.002 0.0006 0.0006
Loa Loa (eye worm) glutathione reductase 0.0051 0.0069 0.0071
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0113 0.0197 0.0202
Schistosoma mansoni fkbp-rapamycin associated protein 0.0903 0.1814 0.1863
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0011 0.0012
Echinococcus granulosus expressed protein 0.0034 0.0035 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0002 0.0002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0202 0.0221
Echinococcus granulosus cpg binding protein 0.0031 0.0028 0.0029
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.005 0.0067 0.0069
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0011 0.0012
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0084 0.0087
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0029 0.003
Plasmodium vivax hypothetical protein, conserved 0.013 0.0232 0.256
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0069 0.0071
Brugia malayi Cytochrome P450 family protein 0.0032 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0021
Echinococcus granulosus intermediate filament protein 0.0027 0.0021 0.0022
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0076 0.0078
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0308 0.0596 0.0612
Plasmodium falciparum protoporphyrinogen oxidase 0.0456 0.09 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0011 0.0012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4774 0.9738 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1601 0.3243 0.333
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0456 0.09 0.0924
Plasmodium falciparum transporter, putative 0.013 0.0232 0.256
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0011 0.0012
Loa Loa (eye worm) norepinephrine transporter 0.0765 0.1532 0.1573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0903 0.1814 0.1863
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0456 0.09 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0084 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.2578 0.5242 0.5383
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0308 0.0596 0.0612
Echinococcus multilocularis serotonin transporter 0.0765 0.1532 0.1573
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.3551 0.7234 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.5747 0.5901
Loa Loa (eye worm) hypothetical protein 0.0506 0.1002 0.1029
Loa Loa (eye worm) hypothetical protein 0.0765 0.1532 0.1573
Toxoplasma gondii SWIRM domain-containing protein 0.005 0.0068 0.0091
Schistosoma mansoni hypothetical protein 0.0308 0.0596 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0308 0.0596 0.0612
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0308 0.0596 0.058
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0038 0.0041
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0022
Entamoeba histolytica protein kinase rad3, putative 0.0903 0.1814 0.1835
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0084 0.0084
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0021 0.0022
Schistosoma mansoni rotamase 0.0034 0.0035 0.0036
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.002 0.0006 0.0006
Mycobacterium ulcerans lipase LipD 0.0035 0.0038 0.0037
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0011 0.0012
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0308 0.0596 0.0611
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.013 0.0232 0.0238
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0031 0.0033
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0039 0.0045 0.0046
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0308 0.0596 0.0612
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0012
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0308 0.0596 0.0612
Echinococcus granulosus lysine specific histone demethylase 1A 0.0926 0.186 0.191
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2258 0.4587 0.471
Schistosoma mansoni hypothetical protein 0.0032 0.0031 0.0032
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0308 0.0596 0.0611
Loa Loa (eye worm) cytochrome P450 family protein 0.009 0.015 0.0154
Brugia malayi Pre-SET motif family protein 0.0031 0.0029 0.003
Leishmania major cytochrome p450-like protein 0.0032 0.0031 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0031 0.0033
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0038 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.1601 0.3243 0.3329
Echinococcus granulosus glutamate receptor subunit protein glur 0.002 0.0006 0.0006
Leishmania major fk506-binding protein 1-like protein 0.0058 0.0084 0.0084
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0058 0.0084 0.0082
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0308 0.0596 0.0822
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0308 0.0596 0.0611
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.013 0.0232 0.0318
Loa Loa (eye worm) phosphatidylinositol 3 0.0308 0.0596 0.0612
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.058
Brugia malayi beta-lactamase 0.0035 0.0038 0.0039
Echinococcus multilocularis Zinc finger, PHD finger 0.0308 0.0596 0.0612
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0031 0.003
Brugia malayi Glutamate receptor 2 precursor 0.0041 0.0049 0.005
Schistosoma mansoni hypothetical protein 0.0352 0.0686 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7739 0.7946
Mycobacterium tuberculosis Possible oxidoreductase 0.0456 0.09 0.0991
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0456 0.09 0.0924
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0049 0.0049
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0058 0.0084 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0596 0.0611
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.3551 0.7234 0.7428
Loa Loa (eye worm) phosphatidylinositol 3 0.0308 0.0596 0.0612
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0308 0.0596 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.3551 0.7234 0.7428
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.3551 0.7234 0.7428
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0308 0.0596 0.0612
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0057 0.0058
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4774 0.9738 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0031 0.0033
Schistosoma mansoni glutamate receptor NMDA 0.0045 0.0057 0.0058
Brugia malayi intermediate filament protein 0.0027 0.0021 0.0022
Loa Loa (eye worm) serotonin transporter b 0.0765 0.1532 0.1573
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0038 0.0041
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.0611
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1006 0.2025 0.2798
Schistosoma mansoni sodium-dependent amino acid transporter 0.013 0.0232 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.1601 0.3243 0.3329
Trichomonas vaginalis set domain proteins, putative 0.024 0.0457 0.0468
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0035 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0903 0.1814 0.1861
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.002 0.0006 0.0006
Leishmania major cytochrome p450-like protein 0.0032 0.0031 0.0031
Leishmania major phosphatidylinositol 4-kinase, putative 0.0308 0.0596 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7739 0.7946
Leishmania major phosphatidylinositol kinase related protein, putative 0.0308 0.0596 0.0611
Brugia malayi Sodium:neurotransmitter symporter family protein 0.013 0.0232 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0068 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0038 0.0039
Toxoplasma gondii hypothetical protein 0.013 0.0232 0.0318
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0021 0.0022
Toxoplasma gondii hypothetical protein 0.013 0.0232 0.0318
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0218 0.0224
Mycobacterium ulcerans monoamine oxidase 0.0456 0.09 0.0899
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0903 0.1814 0.1863
Brugia malayi FAT domain containing protein 0.0698 0.1395 0.1432
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0308 0.0596 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.1183 0.1214
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0308 0.0596 0.0822
Loa Loa (eye worm) cytochrome P450 0.0032 0.0031 0.0032
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0926 0.186 0.191
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0031 0.0041
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0033 0.0033
Giardia lamblia hypothetical protein 0.005 0.0068 0.0068
Schistosoma mansoni glutamate receptor AMPA 0.0041 0.0049 0.005
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0332 0.0644 0.0662
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0033 0.0033
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0308 0.0596 0.0612
Echinococcus multilocularis musashi 0.0027 0.0021 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0031 0.0033
Schistosoma mansoni cpg binding protein 0.0029 0.0025 0.0025
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0033 0.0033
Echinococcus multilocularis sodium and chloride dependent glycine 0.013 0.0232 0.0238
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0058 0.0084 0.0914
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0084 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0903 0.1814 0.1863
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0031 0.003
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.013 0.0232 0.0318
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0031 0.0031
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0084 0.0084
Echinococcus multilocularis conserved hypothetical protein 0.0698 0.1395 0.1432
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0057 0.0058
Plasmodium falciparum glutathione reductase 0.0051 0.0069 0.0753
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0084 0.0084
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4774 0.9738 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0113 0.0197 0.0202
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0031 0.003
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0308 0.0596 0.0612
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0031 0.0033
Schistosoma mansoni glutamate receptor kainate 0.0041 0.0049 0.005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0011 0.001
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1601 0.3243 0.333
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0308 0.0596 0.0822
Loa Loa (eye worm) phosphatidylinositol 3 0.1601 0.3243 0.333
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0038 0.0038
Plasmodium vivax hypothetical protein 0.0308 0.0596 0.6618
Brugia malayi Myb-like DNA-binding domain containing protein 0.0322 0.0625 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.3551 0.7234 0.7428
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0038 0.0038
Schistosoma mansoni glutamate receptor AMPA 0.0041 0.0049 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.2578 0.5242 0.5383
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0308 0.0596 0.0611
Loa Loa (eye worm) hypothetical protein 0.0926 0.186 0.191
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0308 0.0596 0.0611
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0202 0.0221
Plasmodium vivax hypothetical protein, conserved 0.0456 0.09 1
Brugia malayi Serotonin receptor 0.0482 0.0953 0.0978
Schistosoma mansoni hypothetical protein 0.0352 0.0686 0.0704
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0031 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.0808 0.083
Loa Loa (eye worm) hypothetical protein 0.0973 0.1957 0.201
Onchocerca volvulus 0.0308 0.0596 0.3038
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.0011 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.2574 0.5234 0.5374
Loa Loa (eye worm) phosphatidylinositol 3 0.0308 0.0596 0.0612
Schistosoma mansoni immunophilin 0.005 0.0067 0.0069
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0031 0.0033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0181 0.0185
Schistosoma mansoni lamin 0.0027 0.0021 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.4076 0.8309 0.8532
Mycobacterium tuberculosis Conserved protein 0.0035 0.0038 0.0041
Toxoplasma gondii histone lysine-specific demethylase 0.0456 0.09 0.1242
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0308 0.0596 0.0611
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0031 0.0033
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0308 0.0596 0.0611
Mycobacterium ulcerans oxidoreductase 0.0456 0.09 0.0899
Entamoeba histolytica hypothetical protein 0.0308 0.0596 0.058
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0001 0.0002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0308 0.0596 0.0612
Entamoeba histolytica hypothetical protein 0.0308 0.0596 0.058
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0031 0.0033
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0005 0.0021
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0903 0.1814 0.1861
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0903 0.1814 0.1861
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0029 0.003
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1983 0.4025 0.4132
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0038 0.0041
Echinococcus multilocularis 0.0456 0.09 0.0924
Trichomonas vaginalis PIKK family atypical protein kinase 0.1601 0.3243 0.3329
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0698 0.1395 0.1432
Mycobacterium ulcerans hypothetical protein 0.0035 0.0038 0.0037
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1601 0.3243 0.3329
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0031 0.0033
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0038 0.0037
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0031 0.003
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0021 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7739 0.7946
Brugia malayi amine oxidase, flavin-containing family protein 0.0506 0.1002 0.1029
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0005 0.0035
Schistosoma mansoni cpg binding protein 0.0031 0.0028 0.0029
Trichomonas vaginalis fk506-binding protein, putative 0.0058 0.0084 0.0084
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0045 0.0057 0.0058
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0458 0.0904 0.1247
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0308 0.0596 0.0612
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0038 0.0041
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0031 0.0031
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0113 0.0197 0.0202
Leishmania major phosphatidylinositol 3-kinase, putative 0.1601 0.3243 0.3329
Loa Loa (eye worm) hypothetical protein 0.0308 0.0596 0.0612
Plasmodium falciparum thioredoxin reductase 0.0051 0.0069 0.0753
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0058 0.0084 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0038 0.0409
Schistosoma mansoni sodium/chloride dependent transporter 0.013 0.0232 0.0238
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0308 0.0596 0.6618
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0202 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0903 0.1814 0.1861
Loa Loa (eye worm) hypothetical protein 0.0976 0.1962 0.2015
Onchocerca volvulus 0.0029 0.0025 0.0126
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0038 0.0041
Echinococcus granulosus glutamate NMDA receptor subunit 0.0041 0.0049 0.005
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0049 0.0049
Chlamydia trachomatis glutamine binding protein 0.0019 0.0005 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.2574 0.5234 0.5374
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0456 0.09 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0001 0.5
Plasmodium vivax amine transporter, putative 0.013 0.0232 0.256
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0031 0.0033
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.002 0.0006 0.0006
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0033 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.3551 0.7234 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.2578 0.5242 0.5383
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0031 0.0033
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0308 0.0596 0.6618
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0308 0.0596 0.0612
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0308 0.0596 0.0611
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0005 0.0003
Echinococcus multilocularis lamin 0.0027 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0039
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0011 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7739 0.7946
Plasmodium vivax glutathione reductase, putative 0.0051 0.0069 0.0753
Loa Loa (eye worm) glutamate receptor 1 0.0041 0.0049 0.005
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4774 0.9738 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0038 0.0079
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0308 0.0596 0.6618
Loa Loa (eye worm) glutamate receptor 2 0.0041 0.0049 0.005
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0049 0.0051
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.013 0.0232 0.0238
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0049 0.0051
Leishmania major hypothetical protein, conserved 0.0035 0.0038 0.0038
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0084 0.0084
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0113 0.0197 0.0202
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0093 0.0096
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0308 0.0596 0.0611
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0033 0.0033
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0058 0.0084 0.0086
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0228 0.025
Brugia malayi Cytochrome P450 family protein 0.009 0.015 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.4774 0.9738 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0049 0.0051
Onchocerca volvulus 0.013 0.0232 0.118
Onchocerca volvulus CoRest homolog 0.0332 0.0644 0.3283
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0011 0.0012
Toxoplasma gondii ABC1 family protein 0.0035 0.0038 0.0051
Echinococcus multilocularis fk506 binding protein 0.0058 0.0084 0.0086
Loa Loa (eye worm) hypothetical protein 0.013 0.0232 0.0238
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0057 0.0058
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0031 0.003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.013 0.0232 0.0238
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.0611
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0038 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0025 0.0025
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0308 0.0596 0.0612
Brugia malayi CXXC zinc finger family protein 0.0029 0.0025 0.0025
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0308 0.0596 0.0611
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0025 0.0026
Loa Loa (eye worm) hypothetical protein 0.0098 0.0166 0.0171
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0084 0.0086
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.013 0.0232 0.256
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0039
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0001 0.5
Toxoplasma gondii thioredoxin reductase 0.0051 0.0069 0.0094
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.013 0.0232 0.0318
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0058 0.0084 0.0914
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0031 0.003
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1601 0.3243 0.3329
Trichomonas vaginalis PIKK family atypical protein kinase 0.4774 0.9738 1
Mycobacterium ulcerans dehydrogenase 0.0456 0.09 0.0899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0903 0.1814 0.1861
Brugia malayi Glutamate receptor 1 precursor 0.0041 0.0049 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0011 0.0012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0456 0.09 0.0991
Loa Loa (eye worm) hypothetical protein 0.005 0.0068 0.0069
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0308 0.0596 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.2574 0.5234 0.5374
Schistosoma mansoni immunophilin 0.0058 0.0084 0.0086
Loa Loa (eye worm) hypothetical protein 0.013 0.0232 0.0238
Brugia malayi Pre-SET motif family protein 0.0211 0.0398 0.0409
Onchocerca volvulus 0.0976 0.1962 1
Echinococcus granulosus sodium and chloride dependent glycine 0.013 0.0232 0.0238
Echinococcus multilocularis glutamate receptor subunit protein glur 0.002 0.0006 0.0006
Echinococcus granulosus uncharacterized sodium dependent transporter 0.013 0.0232 0.0238
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0084 0.0087
Schistosoma mansoni hypothetical protein 0.0698 0.1395 0.1432
Brugia malayi beta-lactamase family protein 0.0035 0.0038 0.0039
Echinococcus multilocularis 0.0308 0.0596 0.0612
Loa Loa (eye worm) hypothetical protein 0.1006 0.2025 0.208
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0765 0.1532 0.1573
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0031 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0308 0.0596 0.0612
Schistosoma mansoni glutamate receptor kainate 0.0041 0.0049 0.005
Giardia lamblia Phosphatidylinositol 4-kinase 0.0308 0.0596 0.0611
Echinococcus granulosus lysine specific histone demethylase 1A 0.0456 0.09 0.0924
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0058 0.0084 0.0086
Trypanosoma cruzi target of rapamycin kinase 3 0.3801 0.7747 0.7955
Leishmania major phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7739 0.7946
Trichomonas vaginalis PIKK family atypical protein kinase 0.2853 0.5805 0.596
Onchocerca volvulus 0.0765 0.1532 0.7806
Brugia malayi SWIRM domain containing protein 0.0976 0.1962 0.2015
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0765 0.1532 0.1573
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0322 0.0625 0.0642
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.013 0.0232 0.0238
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0038 0.0038
Leishmania major UDP-galactopyranose mutase 0.0456 0.09 0.0923
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0038 0.0039
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4774 0.9738 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.058
Loa Loa (eye worm) hypothetical protein 0.0095 0.0161 0.0165
Echinococcus multilocularis protoporphyrinogen oxidase 0.0456 0.09 0.0924
Schistosoma mansoni cpg binding protein 0.0031 0.0028 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0038 0.0038
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0456 0.09 1
Schistosoma mansoni hypothetical protein 0.0052 0.0073 0.0075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0039
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0202 0.1962
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.3099 0.631 0.6479
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0084 0.0091
Toxoplasma gondii FATC domain-containing protein 0.0903 0.1814 0.2506
Echinococcus granulosus hypothetical protein 0.0715 0.1429 0.1468
Onchocerca volvulus 0.0308 0.0596 0.3038
Chlamydia trachomatis protoporphyrinogen oxidase 0.0456 0.09 1
Onchocerca volvulus 0.0035 0.0038 0.0195
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0033 0.0033
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0031 0.003
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0308 0.0596 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.2853 0.5805 0.596
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0308 0.0596 0.0611
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0228 0.025
Loa Loa (eye worm) hypothetical protein 0.013 0.0232 0.0238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0308 0.0596 0.0612
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0308 0.0596 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.4774 0.9738 1
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0002 0.0002
Echinococcus granulosus serine protein kinase ATM 0.0903 0.1814 0.1863
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0765 0.1532 0.1573
Schistosoma mansoni SWI/SNF complex-related 0.005 0.0068 0.0069
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0308 0.0596 0.0612
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0308 0.0596 0.0611
Schistosoma mansoni ATP-binding cassette transporter 0.0041 0.0049 0.005
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0084 0.0087
Loa Loa (eye worm) hypothetical protein 0.013 0.0232 0.0238
Echinococcus granulosus sodium and chloride dependent glycine 0.013 0.0232 0.0238
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0308 0.0596 0.0611
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1601 0.3243 0.333
Loa Loa (eye worm) hypothetical protein 0.0903 0.1814 0.1863
Giardia lamblia GTOR 0.4774 0.9738 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0084 0.0084
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0031 0.003
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0031 0.0031
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0926 0.186 0.191
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0308 0.0596 0.0612
Trypanosoma brucei trypanothione reductase 0.0051 0.0069 0.0069
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.1601 0.3243 0.3329
Onchocerca volvulus 0.0035 0.0038 0.0195
Trichomonas vaginalis immunophilin, putative 0.0058 0.0084 0.0084
Schistosoma mansoni sodium/chloride dependent transporter 0.013 0.0232 0.0238
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0011 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.1281 0.2588 0.2656
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0038 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0049 0.0049
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0005 0.0003
Loa Loa (eye worm) phosphatidylinositol kinase 0.0308 0.0596 0.0612
Mycobacterium leprae conserved hypothetical protein 0.0308 0.0596 0.6502
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0308 0.0596 0.0611
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0308 0.0596 0.058
Loa Loa (eye worm) hypothetical protein 0.0595 0.1183 0.1215
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0001 0.0002
Echinococcus granulosus geminin 0.0352 0.0686 0.0704
Loa Loa (eye worm) phosphatidylinositol 3 0.4774 0.9738 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0011 0.0012
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0084 0.0084
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0016 0.0017
Loa Loa (eye worm) solute carrier family 6 member 4 0.0765 0.1532 0.1573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0308 0.0596 0.0612
Treponema pallidum sodium- and chloride- dependent transporter 0.0765 0.1532 1
Echinococcus granulosus glutamate receptor 2 0.0045 0.0057 0.0058
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0031 0.003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0202 0.0221
Leishmania major hypothetical protein, unknown function 0.0308 0.0596 0.0611
Brugia malayi beta-lactamase family protein 0.0035 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.013 0.0232 0.0238
Mycobacterium tuberculosis Conserved protein 0.0035 0.0038 0.0041
Trichomonas vaginalis esterase, putative 0.0035 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.3551 0.7234 0.7428
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0011 0.0012
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0161 0.0165
Entamoeba histolytica hypothetical protein 0.0903 0.1814 0.1835
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.003
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0058 0.0084 0.0084
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0308 0.0596 0.0611
Brugia malayi Cytochrome P450 family protein 0.0041 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0038 0.0038
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0084 0.0087
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0033 0.0033
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0058 0.0084 0.0084
Mycobacterium tuberculosis Probable reductase 0.0115 0.0202 0.0221
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0035 0.0036
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0031 0.003
Entamoeba histolytica hypothetical protein 0.0308 0.0596 0.058
Loa Loa (eye worm) hypothetical protein 0.0095 0.0161 0.0165
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0308 0.0596 0.0611
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0005 0.0021
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0011 0.0012
Brugia malayi Cytochrome P450 family protein 0.0041 0.0049 0.0051
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0308 0.0596 0.0611
Giardia lamblia Hypothetical protein 0.0308 0.0596 0.0611
Echinococcus multilocularis sodium and chloride dependent glycine 0.013 0.0232 0.0238
Leishmania major phosphatidylinositol kinase, putative 0.0308 0.0596 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.2825 0.5747 0.5901
Trichomonas vaginalis PIKK family atypical protein kinase 0.2578 0.5242 0.5383
Echinococcus multilocularis serine protein kinase ATM 0.0903 0.1814 0.1863
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1601 0.3243 0.3329
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0031 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.013 0.0232 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0031 0.0033
Schistosoma mansoni sodium/chloride dependent transporter 0.0765 0.1532 0.1573
Toxoplasma gondii target of rapamycin (TOR), putative 0.3551 0.7234 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0057 0.0058
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0084 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0068 0.0068
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0228 0.2265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0029 0.003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0049 0.0048
Echinococcus granulosus nmda type glutamate receptor 0.0039 0.0045 0.0046
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0308 0.0596 0.0612
Onchocerca volvulus 0.013 0.0232 0.118
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0031 0.003
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.058
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0031 0.0033
Mycobacterium tuberculosis Conserved hypothetical protein 0.0308 0.0596 0.0656
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0031 0.0033
Schistosoma mansoni hypothetical protein 0.0412 0.0808 0.083
Onchocerca volvulus 0.0031 0.0029 0.0146
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0038 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.1006 0.2025 0.2078
Echinococcus granulosus lamin dm0 0.0027 0.0021 0.0022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0069 0.0071
Schistosoma mansoni lamin 0.0027 0.0021 0.0022
Loa Loa (eye worm) FKBP5 protein 0.0058 0.0084 0.0086
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0308 0.0596 0.0612
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0039
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0031 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.008 0.0109
Brugia malayi glutathione reductase 0.0051 0.0069 0.0071
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0308 0.0596 0.0612
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4774 0.9738 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0595 0.1183 0.1214
Echinococcus multilocularis glutamate receptor 2 0.0045 0.0057 0.0058
Echinococcus multilocularis nmda type glutamate receptor 0.0039 0.0045 0.0046
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.013 0.0232 0.0238
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0033
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0308 0.0596 0.0611
Trypanosoma cruzi UDP-galactopyranose mutase 0.0456 0.09 0.0923
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.6618
Onchocerca volvulus 0.013 0.0232 0.118
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0031 0.0033
Echinococcus multilocularis cpg binding protein 0.0031 0.0028 0.0029
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0057 0.0058
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0058 0.0084 0.0086
Schistosoma mansoni amine oxidase 0.0456 0.09 0.0924
Echinococcus granulosus lamin 0.0027 0.0021 0.0022
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0308 0.0596 0.058
Brugia malayi hypothetical protein 0.0456 0.09 0.0924
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1601 0.3243 0.333
Echinococcus multilocularis expressed protein 0.0034 0.0035 0.0036
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.013 0.0232 0.0238
Entamoeba histolytica SWIRM domain protein 0.005 0.0068 0.0035
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4774 0.9738 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0033 0.0033
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0308 0.0596 0.0611
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0308 0.0596 0.6618
Loa Loa (eye worm) hypothetical protein 0.0698 0.1395 0.1432
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0456 0.09 0.0899
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3801 0.7747 0.7955
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0069 0.0075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0038 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0029 0.003
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0011 0.0012
Onchocerca volvulus 0.0027 0.0021 0.0109
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0038 0.0039
Echinococcus multilocularis glutamate receptor 2 0.0041 0.0049 0.005
Onchocerca volvulus 0.0089 0.0148 0.0755
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0228 0.025
Loa Loa (eye worm) phosphatidylinositol 3 0.0308 0.0596 0.0612
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.005 0.0067 0.0069
Onchocerca volvulus 0.0035 0.0038 0.0195
Loa Loa (eye worm) hypothetical protein 0.013 0.0232 0.0238
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0308 0.0596 0.0611
Loa Loa (eye worm) hypothetical protein 0.0765 0.1532 0.1573
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0031 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0031 0.0033
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0031 0.003
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3801 0.7747 0.7955
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0308 0.0596 0.0611
Leishmania major hypothetical protein, conserved 0.0308 0.0596 0.0611
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0069 0.0071
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0308 0.0596 0.6618
Trichomonas vaginalis rotamase, putative 0.0034 0.0035 0.0034
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0031 0.0031
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0308 0.0596 0.0822
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0308 0.0596 0.6618
Echinococcus granulosus dnaJ subfamily B 0.0412 0.0808 0.083
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0011 0.0012
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0039
Brugia malayi Trypsin family protein 0.0095 0.0161 0.0165
Entamoeba histolytica SWIRM domain protein 0.005 0.0068 0.0035
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0033 0.0033
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4774 0.9738 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0011 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.3203 0.6521 0.6696
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.005 0.0067 0.0069
Mycobacterium tuberculosis Conserved protein 0.0035 0.0038 0.0041
Echinococcus multilocularis NMDA receptor 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0308 0.0596 0.0612
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0308 0.0596 0.0612
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.013 0.0232 0.0238
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.4902 1 1
Onchocerca volvulus 0.0027 0.0021 0.0109
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0698 0.1395 0.1432
Leishmania major peptidylprolyl isomerase-like protein 0.0058 0.0084 0.0084
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.013 0.0232 0.0238
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0011 0.001

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -14 % Serum total cholesterol-lowering activity in the cholesterol-fed rat expressed as the ratio of the observed reduction to the difference between the control and normal levels 100 (10 mg/kg po) ChEMBL. 7636880
IC50 (binding) = 0.012 uM Inhibition of rabbit small-intestinal Acyl coenzyme A:cholesterol acyltransferase 1 ChEMBL. 7636880

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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