Detailed information for compound 189295

Basic information

Technical information
  • TDR Targets ID: 189295
  • Name: N-[(3-methyl-2,3-dihydro-1,4-benzodioxin-2-yl )methyl]-1-(1-pyrimidin-2-ylpiperidin-4-yl)me thanamine
  • MW: 354.446 | Formula: C20H26N4O2
  • H donors: 1 H acceptors: 2 LogP: 2.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1Oc2ccccc2OC1CNCC1CCN(CC1)c1ncccn1
  • InChi: 1S/C20H26N4O2/c1-15-19(26-18-6-3-2-5-17(18)25-15)14-21-13-16-7-11-24(12-8-16)20-22-9-4-10-23-20/h2-6,9-10,15-16,19,21H,7-8,11-14H2,1H3
  • InChiKey: OGJLWAUKNAZCQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(3-methyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-(1-pyrimidin-2-yl-4-piperidyl)methanamine
  • N-[(3-methyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-[1-(2-pyrimidinyl)-4-piperidinyl]methanamine
  • (3-methyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl-[[1-(2-pyrimidyl)-4-piperidyl]methyl]amine
  • (3-methyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl-[(1-pyrimidin-2-yl-4-piperidyl)methyl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor alpha 1A Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1D References
Homo sapiens adrenoceptor alpha 1B References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0133 0.1098 1
Schistosoma mansoni caspase-3 (C14 family) 0.0184 0.1565 0.1565
Schistosoma mansoni caspase-7 (C14 family) 0.0184 0.1565 0.1565
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.1264 0.1264
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0175 0.0175
Echinococcus granulosus endoplasmin 0.0048 0.031 0.031
Onchocerca volvulus 0.0027 0.0118 0.0279
Loa Loa (eye worm) animal heme peroxidase 0.0471 0.4217 0.4217
Schistosoma mansoni cytochrome P450 0.0019 0.0042 0.0042
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Echinococcus granulosus enteropeptidase 0.0029 0.0132 0.0132
Brugia malayi Trypsin family protein 0.0029 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.004 0.0241 0.0209
Brugia malayi beta-lactamase family protein 0.004 0.0241 0.0241
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0042 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0379 0.3365 0.3365
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0241 0.0241
Trypanosoma cruzi heat shock protein, putative 0.0025 0.0095 0.0063
Echinococcus granulosus protein quaking 0.0025 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0132
Schistosoma mansoni carbonic anhydrase 0.0029 0.0138 0.0138
Loa Loa (eye worm) cytochrome P450 0.0019 0.0042 0.0042
Schistosoma mansoni lamin 0.0027 0.0118 0.0118
Brugia malayi Pre-SET motif family protein 0.0028 0.0128 0.0128
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0032 0.0213
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0032 0.0213
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Mycobacterium leprae PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC 0.0027 0.0113 0.0675
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0029 0.0132 0.0132
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0132
Onchocerca volvulus Cell death protein 3 homolog 0.0049 0.0321 0.0762
Trypanosoma brucei heat shock protein, putative 0.006 0.0423 0.0392
Loa Loa (eye worm) hypothetical protein 0.0025 0.01 0.01
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.011 0.0078
Brugia malayi beta-lactamase 0.004 0.0241 0.0241
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0241 0.0209
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Trypanosoma brucei metacaspase MCA3 0.0049 0.0321 0.029
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0241 0.1118
Brugia malayi Carboxylesterase family protein 0.0019 0.0046 0.0046
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.025 0.0219
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0042 0.0297
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0044 0.0276 0.0655
Brugia malayi mbt repeat family protein 0.0054 0.0362 0.0362
Trypanosoma cruzi DNA polymerase eta, putative 0.0029 0.0136 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1264 0.1264
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.1097 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0471 0.4217 0.4217
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0362 0.0362
Brugia malayi Trypsin family protein 0.0029 0.0132 0.0132
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.1097 1 1
Onchocerca volvulus 0.0029 0.0132 0.0314
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0042 0.0297
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0118 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.1264 0.1264
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0133 0.1098 0.1098
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0044 0.0276 0.2453
Loa Loa (eye worm) hypothetical protein 0.004 0.0241 0.0241
Trichomonas vaginalis heat shock protein, putative 0.0048 0.031 0.1488
Loa Loa (eye worm) hypothetical protein 0.0049 0.0321 0.0321
Trichomonas vaginalis ran, putative 0.0024 0.0088 0.0296
Brugia malayi cytochrome P450 0.0019 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0321 0.1548
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0362 0.0362
Schistosoma mansoni peroxidasin 0.0471 0.4217 0.4217
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0042 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0241 0.0241
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1097 1 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0042 0.0009
Echinococcus multilocularis tumor protein p63 0.0313 0.2756 0.2756
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0132 0.0132
Plasmodium vivax importin-beta 2, putative 0.0032 0.0167 0.008
Entamoeba histolytica hypothetical protein 0.0033 0.0175 0.1338
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0042 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni cytochrome oxidase subunit 0.0077 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0041 0.025 0.025
Brugia malayi heat shock protein 90 0.006 0.0423 0.0423
Loa Loa (eye worm) isocitrate dehydrogenase 0.1097 1 1
Brugia malayi Endoplasmin precursor 0.006 0.0423 0.0423
Schistosoma mansoni hypothetical protein 0.0033 0.0175 0.0175
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0138 0.0138
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0321 0.029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0029 0.0138 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0042 0.0009
Echinococcus granulosus geminin 0.0178 0.1513 0.1513
Brugia malayi Isocitrate dehydrogenase 0.1097 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1097 1 1
Brugia malayi Pre-SET motif family protein 0.0193 0.1652 0.1652
Trichomonas vaginalis set domain proteins, putative 0.022 0.1898 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0025 0.0095 0.0589
Schistosoma mansoni eyes absent homolog 0.0082 0.0621 0.0621
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0133 0.1098 0.5713
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0042 0.0009
Schistosoma mansoni lamin 0.0027 0.0118 0.0118
Loa Loa (eye worm) endoplasmin 0.006 0.0423 0.0423
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0321 0.0281
Loa Loa (eye worm) blistered cuticle protein 3 0.0471 0.4217 0.4217
Trypanosoma brucei Heat shock protein 83, putative 0.006 0.0423 0.0392
Echinococcus granulosus cytochrome c oxidase subunit 1 0.0077 0.0576 0.0576
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0321 0.0281
Echinococcus granulosus carbonic anhydrase 0.0029 0.0138 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1264 0.1264
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0133 0.1098 0.8662
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0241 0.1118
Schistosoma mansoni hypothetical protein 0.0045 0.028 0.028
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0094 0.074 0.3791
Trypanosoma brucei heat shock protein 90, putative 0.006 0.0423 0.0392
Onchocerca volvulus 0.004 0.0241 0.0572
Onchocerca volvulus 0.0029 0.0132 0.0314
Echinococcus granulosus cytochrome c oxidase subunit II 0.0146 0.122 0.122
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Mycobacterium tuberculosis Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1) 0.0077 0.0576 0.0545
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Echinococcus granulosus tumor protein p63 0.0313 0.2756 0.2756
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0321 0.029
Loa Loa (eye worm) acetylcholinesterase 1 0.0114 0.0923 0.0923
Schistosoma mansoni amine GPCR 0.0414 0.3695 0.3695
Giardia lamblia Heat shock protein HSP 90-alpha 0.006 0.0423 1
Loa Loa (eye worm) carboxylesterase 0.0019 0.0046 0.0046
Trypanosoma brucei heat shock protein, putative 0.006 0.0423 0.0392
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0132 0.0132
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0042 0.0297
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0133 0.1098 0.1098
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0027 0.0113 0.0113
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0042 0.0297
Entamoeba histolytica heat shock protein 90, putative 0.006 0.0423 0.3667
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0029 0.0132 0.0132
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0431 0.0431
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.1097 1 1
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0321 0.1548
Schistosoma mansoni cpg binding protein 0.0028 0.0127 0.0127
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0019 0.0046 0.0071
Echinococcus granulosus neuroligin 0.0019 0.0046 0.0046
Echinococcus multilocularis para nitrobenzyl esterase 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Trypanosoma cruzi heat shock protein 90, putative 0.0048 0.031 0.0278
Echinococcus multilocularis transmembrane protease serine 3 0.0029 0.0132 0.0132
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0241 0.0241
Brugia malayi CXXC zinc finger family protein 0.0027 0.0113 0.0113
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.1097 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.2254 0.2229
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0138 0.0138
Schistosoma mansoni cytochrome oxidase subunit 0.0077 0.0576 0.0576
Mycobacterium tuberculosis Carboxylesterase LipT 0.0019 0.0046 0.0013
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0195 0.0164
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0241 0.0209
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Onchocerca volvulus 0.0027 0.0118 0.0279
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0088 0.0055
Brugia malayi Cell death protein 3 precursor 0.0049 0.0321 0.0321
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0146 0.122 1
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0362 0.0362
Toxoplasma gondii heat shock protein 75, putative 0.0025 0.0095 0.0054
Onchocerca volvulus 0.0029 0.0132 0.0314
Brugia malayi Blistered cuticle protein 3 0.0471 0.4217 0.4217
Mycobacterium ulcerans lipase LipD 0.004 0.0241 0.2129
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0129 0.1055 0.1055
Loa Loa (eye worm) hypothetical protein 0.004 0.0241 0.0241
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0032 0.0032
Mycobacterium ulcerans heat shock protein 90 0.0048 0.031 0.2762
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.003 0.0146 0.0114
Onchocerca volvulus 0.0028 0.0128 0.0304
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0094 0.074 0.3791
Schistosoma mansoni cpg binding protein 0.0027 0.0113 0.0113
Onchocerca volvulus Chorion peroxidase homolog 0.0471 0.4217 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0129 0.1055 0.1055
Onchocerca volvulus Peroxidasin homolog 0.0471 0.4217 1
Trichomonas vaginalis heat shock protein, putative 0.0048 0.031 0.1488
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Loa Loa (eye worm) carboxylesterase 0.0114 0.0923 0.0923
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Mycobacterium tuberculosis Conserved protein 0.004 0.0241 0.0209
Brugia malayi hypothetical protein 0.0082 0.0621 0.0621
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0241 0.2129
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0208 0.0943
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0042 0.0297
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0241 0.0209
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0025 0.0095 0.0226
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0031 0.0153 0.0153
Mycobacterium ulcerans beta-lactamase 0.004 0.0241 0.2129
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0042 0.0009
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0132
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0138 0.0138
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0042 0.0009
Echinococcus multilocularis survival motor neuron protein 1 0.0219 0.1889 0.1889
Trichomonas vaginalis rotamase, putative 0.0031 0.0153 0.0646
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1097 1 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0362 0.0859
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0128 0.0128
Trichomonas vaginalis spcc417.12 protein, putative 0.0019 0.0046 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0042 0.0042
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0132 0.0132
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0042 0.0009
Echinococcus granulosus carbonic anhydrase II 0.0129 0.1055 0.1055
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1097 1 1
Echinococcus granulosus glycoprotein Antigen 5 0.0029 0.0132 0.0132
Brugia malayi cytochrome c oxidase subunit II 0.0018 0.0031 0.0031
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 1 0.0077 0.0576 0.292
Echinococcus granulosus intermediate filament protein 0.0027 0.0118 0.0118
Echinococcus multilocularis acetylcholinesterase 0.0114 0.0923 0.0923
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Schistosoma mansoni cytochrome oxidase subunit 0.0077 0.0576 0.0576
Trypanosoma brucei heat shock protein, putative 0.006 0.0423 0.0392
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0042 0.0009
Echinococcus multilocularis caspase 3 0.0135 0.1111 0.1111
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0048 0.031 0.0278
Leishmania major cytochrome p450-like protein 0.0019 0.0042 0.0009
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0133 0.1098 0.1098
Brugia malayi Carboxylesterase family protein 0.0019 0.0046 0.0046
Echinococcus granulosus heat shock protein 90 0.0048 0.031 0.031
Onchocerca volvulus 0.0019 0.0046 0.0109
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0128 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1264 0.1264
Toxoplasma gondii Hsp90 domain-containing protein 0.0025 0.0095 0.0054
Brugia malayi mbt repeat family protein 0.0054 0.0362 0.0362
Onchocerca volvulus 0.0019 0.0046 0.0109
Loa Loa (eye worm) hypothetical protein 0.0082 0.0621 0.0621
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Brugia malayi hypothetical protein 0.0219 0.1889 0.1889
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0042 0.0297
Echinococcus granulosus dna polymerase eta 0.0041 0.025 0.025
Brugia malayi tumor suppressor. 0.0298 0.2617 0.2617
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1097 1 1
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0044 0.0276 0.0655
Echinococcus multilocularis caspase 2 0.0049 0.0321 0.0321
Echinococcus granulosus survival motor neuron protein 1 0.0219 0.1889 0.1889
Brugia malayi Animal haem peroxidase family protein 0.0471 0.4217 0.4217
Loa Loa (eye worm) tumor suppressor 0.0298 0.2617 0.2617
Schistosoma mansoni caspase-7 (C14 family) 0.0049 0.0321 0.0321
Brugia malayi Probable isocitrate dehydrogenase 0.0133 0.1098 0.1098
Onchocerca volvulus 0.004 0.0241 0.0572
Schistosoma mansoni heat shock protein 0.006 0.0423 0.0423
Giardia lamblia Heat shock protein HSP 90-alpha 0.0048 0.031 0.7104
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.1818 0.1818
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0032 0.0032
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0042 0.0297
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0129 0.1055 0.1026
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0193 0.1652 0.1652
Schistosoma mansoni cytochrome oxidase subunit 0.0077 0.0576 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0153 0.0646
Schistosoma mansoni isocitrate dehydrogenase 0.0133 0.1098 0.1098
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0362 0.0362
Trypanosoma cruzi metacaspase, putative 0.0049 0.0321 0.029
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0362 0.0362
Brugia malayi Animal haem peroxidase family protein 0.0471 0.4217 0.4217
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.0113
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0018 0.0034 0.0002
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Loa Loa (eye worm) hypothetical protein 0.004 0.0241 0.0241
Onchocerca volvulus 0.0019 0.0046 0.0109
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0132 0.0132
Brugia malayi Cytochrome P450 family protein 0.0019 0.0042 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0118 0.0118
Schistosoma mansoni rotamase 0.0031 0.0153 0.0153
Trypanosoma brucei heat shock protein, putative 0.006 0.0423 0.0392
Onchocerca volvulus 0.0029 0.0132 0.0314
Onchocerca volvulus 0.0046 0.029 0.0688
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0019 0.0046 0.0013
Loa Loa (eye worm) carbonic anhydrase 3 0.0129 0.1055 0.1055
Trypanosoma cruzi heat shock protein 90, putative 0.006 0.0423 0.0392
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0025 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0132
Entamoeba histolytica hypothetical protein 0.0033 0.0175 0.1338
Echinococcus multilocularis caspase 0.0184 0.1565 0.1565
Trypanosoma brucei heat shock protein, putative 0.006 0.0423 0.0392
Echinococcus multilocularis carboxylesterase 5A 0.0114 0.0923 0.0923
Mycobacterium leprae conserved hypothetical protein 0.004 0.0241 0.1888
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0042 0.0297
Echinococcus granulosus carbonic anhydrase 0.0029 0.0138 0.0138
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0029 0.0132 0.0132
Schistosoma mansoni heat shock protein 0.006 0.0423 0.0423
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0028 0.0126 0.1072
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0042 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1097 1 1
Schistosoma mansoni hypothetical protein 0.0326 0.2876 0.2876
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0042 0.0042
Brugia malayi Animal haem peroxidase family protein 0.0471 0.4217 0.4217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus granulosus caspase 2 0.0049 0.0321 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0321 0.1548
Schistosoma mansoni neuroligin 3 (S09 family) 0.0019 0.0046 0.0046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0088 0.0055
Brugia malayi Carboxylesterase family protein 0.0114 0.0923 0.0923
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0138 0.0138
Brugia malayi Trypsin-like protease protein 5 0.0029 0.0132 0.0132
Mycobacterium leprae Probable lipase LipE 0.004 0.0241 0.1888
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0241 0.1118
Echinococcus multilocularis enteropeptidase 0.0029 0.0132 0.0132
Onchocerca volvulus 0.0471 0.4217 1
Schistosoma mansoni DNA polymerase eta 0.0041 0.025 0.025
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0049 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0161 0.1358 0.1358
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0146 0.0114
Schistosoma mansoni hypothetical protein 0.0346 0.3061 0.3061
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Echinococcus granulosus microtubule associated protein 2 0.0639 0.5767 0.5767
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.1264 0.1264
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0042 0.0297
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0095 0.0336
Mycobacterium ulcerans cytochrome C oxidase polypeptide I CtaD 0.0077 0.0576 0.5202
Brugia malayi Peroxidasin 0.0471 0.4217 0.4217
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0088 0.1413
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.025 0.025
Schistosoma mansoni cytochrome-c oxidase 0.0044 0.0276 0.0276
Schistosoma mansoni hypothetical protein 0.0029 0.0132 0.0132
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0031 0.0153 0.0153
Plasmodium vivax metacaspase 1, putative 0.0049 0.0321 0.0236
Trichomonas vaginalis importin beta-1, putative 0.0026 0.011 0.0416
Echinococcus multilocularis BC026374 protein (S09 family) 0.0019 0.0046 0.0046
Brugia malayi Probable isocitrate dehydrogenase 0.0133 0.1098 0.1098
Echinococcus multilocularis musashi 0.0027 0.0118 0.0118
Toxoplasma gondii isocitrate dehydrogenase 0.1097 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.1097 1 1
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0146 0.0114
Schistosoma mansoni hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0167 0.0167
Echinococcus granulosus BC026374 protein S09 family 0.0019 0.0046 0.0046
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0029 0.0132 0.0132
Leishmania major cytochrome p450-like protein 0.0019 0.0042 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0175 0.0175
Onchocerca volvulus Dual oxidase homolog 0.0471 0.4217 1
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.029 0.029
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0133 0.1098 0.1098
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0241 0.0209
Brugia malayi Importin beta-1 subunit 0.0032 0.0167 0.0167
Trypanosoma brucei heat shock protein 84, putative 0.0025 0.0095 0.0063
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0046 0.0046
Brugia malayi hypothetical protein 0.0029 0.0132 0.0132
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0025 0.0095 0.0095
Schistosoma mansoni cytochrome c oxidase subunit II 0.012 0.0974 0.0974
Echinococcus granulosus Mastin 0.0029 0.0132 0.0132
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0018 0.0034 0.0227
Trypanosoma brucei isocitrate dehydrogenase, putative 0.1097 1 1
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0032 0.0162 0.1402
Loa Loa (eye worm) hypothetical protein 0.0046 0.029 0.029
Echinococcus granulosus dnaJ subfamily B 0.0379 0.3365 0.3365
Plasmodium vivax heat shock protein 86, putative 0.006 0.0423 0.0339
Echinococcus multilocularis geminin 0.0178 0.1513 0.1513
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0042 0.0297
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0132 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0241 0.1118
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.028 0.028
Trichomonas vaginalis endoplasmin, putative 0.0037 0.0208 0.0943
Onchocerca volvulus 0.0029 0.0132 0.0314
Schistosoma mansoni carbonic anhydrase-related 0.0029 0.0138 0.0138
Echinococcus granulosus carbonic anhydrase 0.0029 0.0138 0.0138
Echinococcus granulosus lamin dm0 0.0027 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0132
Plasmodium falciparum carbonic anhydrase 0.0029 0.0138 0.0051
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0178 0.1513 0.1513
Echinococcus granulosus importin subunit beta 1 0.0032 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0241 0.0209
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0088 0.0046
Echinococcus granulosus caspase 0.0184 0.1565 0.1565
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.025 0.0219
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Echinococcus multilocularis heat shock protein 90 0.0048 0.031 0.031
Trypanosoma cruzi heat shock protein 85, putative 0.006 0.0423 0.0392
Plasmodium falciparum metacaspase-like protein 0.0049 0.0321 0.0236
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0321 0.0236
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Loa Loa (eye worm) animal heme peroxidase 0.0471 0.4217 0.4217
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Onchocerca volvulus 0.0471 0.4217 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Schistosoma mansoni ran 0.0024 0.0088 0.0088
Brugia malayi Animal haem peroxidase family protein 0.0471 0.4217 0.4217
Schistosoma mansoni endoplasmin 0.006 0.0423 0.0423
Toxoplasma gondii isocitrate dehydrogenase 0.1097 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0241 0.0241
Loa Loa (eye worm) MBCTL1 0.0061 0.0431 0.0431
Echinococcus multilocularis peroxidasin 0.0471 0.4217 0.4217
Onchocerca volvulus 0.0471 0.4217 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0042 0.0297
Echinococcus granulosus caspase 3 0.0135 0.1111 0.1111
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0042 0.0009
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0088 0.0088
Schistosoma mansoni biogenic amine (5HT) receptor 0.0161 0.1358 0.1358
Echinococcus multilocularis neuroligin 0.0019 0.0046 0.0046
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0138 0.0138
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0321 0.0281
Schistosoma mansoni BC026374 protein (S09 family) 0.0019 0.0046 0.0046
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0129 0.1055 0.1055
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0167 0.0135
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0133 0.1098 0.1098
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0042 0.0009
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0042 0.0297
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.011 0.0416
Loa Loa (eye worm) carboxylesterase 0.0019 0.0046 0.0046
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0132 0.0132
Trichomonas vaginalis aldehyde oxidase, putative 0.0094 0.074 0.3791
Brugia malayi Carboxylesterase family protein 0.0019 0.0046 0.0046
Onchocerca volvulus Peroxidase homolog 0.0471 0.4217 1
Echinococcus multilocularis snurportin 1 0.0346 0.3061 0.3061
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0138 0.0138
Trypanosoma cruzi metacaspase, putative 0.0049 0.0321 0.029
Schistosoma mansoni ran 0.0024 0.0088 0.0088
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0042 0.0009
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0042 0.0297
Plasmodium vivax endoplasmin, putative 0.006 0.0423 0.0339
Loa Loa (eye worm) hypothetical protein 0.0061 0.0431 0.0431
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0128 0.0087
Echinococcus granulosus cpg binding protein 0.0028 0.0127 0.0127
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0184 0.1565 0.1565
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Entamoeba histolytica hypothetical protein 0.0033 0.0175 0.1338
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0042 0.0297
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0044 0.0276 0.0236
Echinococcus multilocularis isocitrate dehydrogenase 0.1097 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0128 0.0128
Giardia lamblia Grp94/Hsp90 0.0048 0.031 0.7104
Leishmania major metacaspase, putative 0.0049 0.0321 0.029
Plasmodium falciparum cytochrome c oxidase subunit 1 0.0077 0.0576 0.0492
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0042 0.0297
Leishmania major GTP-binding protein, putative 0.0024 0.0088 0.0055
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0088 0.0088
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0128 0.0128
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0146 0.1068
Trypanosoma brucei heat shock protein, putative 0.006 0.0423 0.0392
Echinococcus multilocularis Mastin 0.0029 0.0132 0.0132
Plasmodium vivax cytochrome c oxidase subunit I 0.0077 0.0576 0.0492
Loa Loa (eye worm) hypothetical protein 0.0161 0.1358 0.1358
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0128 0.0128
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0046 0.0046
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0042 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0241 0.0209
Loa Loa (eye worm) hypothetical protein 0.004 0.0241 0.0241
Schistosoma mansoni acetylcholinesterase 0.0019 0.0046 0.0046
Mycobacterium leprae PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) 0.0077 0.0576 0.5056
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0063 0.0445 0.4003
Brugia malayi hypothetical protein 0.0025 0.01 0.01
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0042 0.0297
Echinococcus multilocularis endoplasmin 0.0048 0.031 0.031
Schistosoma mansoni microtubule-associated protein tau 0.0639 0.5767 0.5767
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0138 0.0138
Mycobacterium ulcerans hypothetical protein 0.0029 0.0132 0.1132
Mycobacterium tuberculosis Conserved protein 0.004 0.0241 0.0209
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0241 0.0209
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0175 0.0175
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Plasmodium vivax SET domain protein, putative 0.0028 0.0128 0.0041
Onchocerca volvulus 0.0077 0.0576 0.1365
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0042 0.0297
Plasmodium falciparum endoplasmin, putative 0.0037 0.0208 0.0122
Plasmodium falciparum heat shock protein 90, putative 0.0025 0.0095 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis heat shock protein 90 0.006 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Leishmania major DNA polymerase eta, putative 0.0029 0.0136 0.0104
Echinococcus granulosus snurportin 1 0.0346 0.3061 0.3061
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0129 0.1055 0.1055
Entamoeba histolytica heat shock protein 90, putative 0.006 0.0423 0.3667
Entamoeba histolytica Ran family GTPase 0.0024 0.0088 0.0518
Echinococcus granulosus heat shock protein 90 0.006 0.0423 0.0423
Brugia malayi Carboxylesterase family protein 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0045 0.0279 0.0247
Toxoplasma gondii heat shock protein HSP90 0.006 0.0423 0.0383
Trypanosoma cruzi heat shock protein 85, putative 0.006 0.0423 0.0392
Schistosoma mansoni hypothetical protein 0.0178 0.1513 0.1513
Loa Loa (eye worm) cytochrome c oxidase subunit II 0.0018 0.0031 0.0031
Echinococcus multilocularis microtubule associated protein 2 0.0639 0.5767 0.5767
Onchocerca volvulus 0.0029 0.0132 0.0314
Loa Loa (eye worm) hypothetical protein 0.0082 0.0621 0.0621
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0241 0.0241
Echinococcus granulosus expressed protein 0.0031 0.0153 0.0153
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0431 0.0431
Schistosoma mansoni heat shock protein 0.0025 0.0095 0.0095
Toxoplasma gondii hypothetical protein 0.0029 0.0138 0.0097
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0132 0.0132
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0044 0.0276 0.0655
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0042 0.0009
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0431 0.0431
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0048 0.031 0.2541
Onchocerca volvulus 0.0019 0.0046 0.0109
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.1264 0.1264
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0018 0.0034 0.0227
Onchocerca volvulus 0.0045 0.028 0.0664
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0019 0.0046 0.0046
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0184 0.1565 0.1565
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0128 0.0128
Trichomonas vaginalis rotamase, putative 0.003 0.0146 0.061
Mycobacterium ulcerans carboxylesterase, LipT 0.0019 0.0046 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0321 0.1548
Trypanosoma cruzi metacaspase, putative 0.0049 0.0321 0.029
Leishmania major isocitrate dehydrogenase, putative 0.0133 0.1098 0.1069
Echinococcus multilocularis carbonic anhydrase 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Loa Loa (eye worm) hypothetical protein 0.0114 0.0923 0.0923
Trichomonas vaginalis heat shock protein, putative 0.006 0.0423 0.2095
Plasmodium vivax heat shock protein, putative 0.0025 0.0095 0.0008
Brugia malayi beta-lactamase family protein 0.004 0.0241 0.0241
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0133 0.1098 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0431 0.0431
Schistosoma mansoni unc-13 (munc13) 0.0133 0.1098 0.1098
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0128 0.0128
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0032 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0042 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0241 0.0241
Loa Loa (eye worm) heat shock protein 90 0.006 0.0423 0.0423
Echinococcus granulosus hypothetical protein 0.0025 0.01 0.01
Brugia malayi intermediate filament protein 0.0027 0.0118 0.0118
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.1264 0.1264
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0029 0.0136 0.0095
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0362 0.0362
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0133 0.1098 0.1098
Echinococcus granulosus heat shock protein 0.006 0.0423 0.0423
Echinococcus multilocularis glycoprotein Antigen 5 0.0029 0.0132 0.0132
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0019 0.0046 0.0013
Trypanosoma brucei carbonic anhydrase-like protein 0.0129 0.1055 0.1026
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0042 0.0009
Loa Loa (eye worm) hypothetical protein 0.0054 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.0025 0.01 0.01
Trypanosoma brucei heat shock protein 90, putative 0.006 0.0423 0.0392
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0241 0.0209
Onchocerca volvulus 0.0019 0.0046 0.0109
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0032 0.0032
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0048 0.031 0.031
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0241 0.1118
Mycobacterium ulcerans hypothetical protein 0.004 0.0241 0.2129
Leishmania major DNA polymerase eta, putative 0.0041 0.025 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0042 0.0009
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0042 0.0297
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0032 0.0162 0.013
Schistosoma mansoni gliotactin 0.0019 0.0046 0.0046
Echinococcus multilocularis serotonin receptor 0.0161 0.1358 0.1358
Trypanosoma brucei heat shock protein, putative 0.006 0.0423 0.0392
Echinococcus granulosus biogenic amine 5HT receptor 0.0161 0.1358 0.1358
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0042 0.0009
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0133 0.1098 0.1098
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0042 0.0042
Brugia malayi hypothetical protein 0.0033 0.0175 0.0175
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0045 0.0279 0.2474
Echinococcus granulosus dna polymerase kappa 0.0018 0.0032 0.0032
Plasmodium falciparum importin beta, putative 0.0032 0.0167 0.008
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0088 0.0088
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0049 0.0321 0.0321
Echinococcus granulosus acetylcholinesterase 0.0114 0.0923 0.0923
Loa Loa (eye worm) cytochrome c oxidase subunit I 0.0031 0.0158 0.0158
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0113 0.0113
Loa Loa (eye worm) heat shock protein 75 0.0025 0.0095 0.0095
Brugia malayi RNA, U transporter 1 0.0092 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus granulosus peroxidasin 0.0471 0.4217 0.4217
Brugia malayi hypothetical protein 0.0471 0.4217 0.4217
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0167 0.0126
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0042 0.0297
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Leishmania major cytochrome p450-like protein 0.0019 0.0042 0.0009
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0102 0.0811 0.073
Echinococcus granulosus carboxylesterase 5A 0.0114 0.0923 0.0923
Treponema pallidum hypothetical protein 0.0015 0.0009 0.0108
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0431 0.0431
Plasmodium vivax heat shock protein 90, putative 0.0025 0.0095 0.0008
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0045 0.0279 0.2474
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.011 0.0416
Plasmodium vivax hypothetical protein, conserved 0.004 0.0241 0.0155
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0342 0.0302
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0133 0.1098 0.1098
Mycobacterium ulcerans cytochrome C oxidase polypeptide I CtaD 0.0077 0.0576 0.5202
Schistosoma mansoni intermediate filament proteins 0.0027 0.0118 0.0118
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0044 0.0276 0.0655
Treponema pallidum heat shock protein 90 0.0048 0.031 1
Trypanosoma brucei heat shock protein, putative 0.006 0.0423 0.0392
Schistosoma mansoni importin beta-1 0.0032 0.0167 0.0167
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Echinococcus multilocularis caspase 8 0.0049 0.0321 0.0321
Brugia malayi Temporarily assigned gene name protein 44 0.0025 0.01 0.01
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0042 0.0009
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0029 0.0138 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0241 0.0209
Entamoeba histolytica hypothetical protein 0.0026 0.011 0.0728
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Trypanosoma brucei metacaspase 5, putative 0.0049 0.0321 0.029
Onchocerca volvulus 0.0054 0.0362 0.0859
Entamoeba histolytica hypothetical protein 0.0033 0.0175 0.1338
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.031 0.0278
Loa Loa (eye worm) hypothetical protein 0.0114 0.0923 0.0923
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Toxoplasma gondii heat shock protein 90, putative 0.006 0.0423 0.0383
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0167 0.0135
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0431 0.0431
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0029 0.0138 0.0138
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0044 0.0276 0.0245
Schistosoma mansoni cytochrome c oxidase subunit I 0.0031 0.0158 0.0158
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0032 0.0162 0.1402
Schistosoma mansoni hypothetical protein 0.0025 0.01 0.01
Loa Loa (eye worm) trypsin family protein 0.0029 0.0132 0.0132
Trichomonas vaginalis esterase, putative 0.004 0.0241 0.1118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Onchocerca volvulus 0.022 0.1898 0.4501
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0042 0.0009
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0042 0.0009
Echinococcus granulosus caspase 8 0.0049 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0132
Onchocerca volvulus Peroxidasin homolog 0.0471 0.4217 1
Loa Loa (eye worm) animal heme peroxidase 0.0471 0.4217 0.4217
Loa Loa (eye worm) beta-lactamase 0.004 0.0241 0.0241
Entamoeba histolytica tartrate dehydrogenase, putative 0.0133 0.1098 1
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0133 0.1098 0.1069
Echinococcus granulosus lamin 0.0027 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Echinococcus multilocularis serotonin receptor 0.0161 0.1358 0.1358
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0133 0.1098 0.1098
Echinococcus granulosus para nitrobenzyl esterase 0.0019 0.0046 0.0046
Toxoplasma gondii ABC1 family protein 0.004 0.0241 0.02
Onchocerca volvulus 0.004 0.0241 0.0572
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.1818 0.1818
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Trypanosoma brucei metacaspase MCA2 0.0049 0.0321 0.029
Echinococcus multilocularis heat shock protein 0.006 0.0423 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0321 0.1548
Trypanosoma brucei metacaspase 0.0049 0.0321 0.029
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0118 0.0118
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0132 0.0132
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0048 0.031 0.0278
Schistosoma mansoni peroxidasin 0.0471 0.4217 0.4217
Trichomonas vaginalis heat shock protein, putative 0.0048 0.031 0.1488
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Brugia malayi Trypsin family protein 0.0029 0.0132 0.0132
Leishmania major carbonic anhydrase-like protein 0.0129 0.1055 0.1026
Echinococcus multilocularis cpg binding protein 0.0028 0.0127 0.0127
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0114 0.0923 0.0923
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Onchocerca volvulus Peroxidase homolog 0.0471 0.4217 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0042 0.0009
Brugia malayi Trypsin family protein 0.0029 0.0132 0.0132
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0241 0.2129
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0042 0.0009
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.3061 0.3061
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0241 0.0209
Brugia malayi Cytochrome P450 family protein 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0321 0.0321
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0362 0.0362
Brugia malayi hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis carbonic anhydrase II 0.0129 0.1055 0.1055
Leishmania major heat shock protein, putative 0.0025 0.0095 0.0063
Echinococcus multilocularis expressed protein 0.0031 0.0153 0.0153
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0042 0.0009
Echinococcus multilocularis 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0219 0.1889 0.1889
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0398 0.0398
Brugia malayi Carboxylesterase family protein 0.0114 0.0923 0.0923
Echinococcus granulosus transmembrane protease serine 3 0.0029 0.0132 0.0132
Brugia malayi Cytochrome P450 family protein 0.0019 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0321 0.1548
Leishmania major heat shock protein 83-1 0.006 0.0423 0.0392
Brugia malayi Animal haem peroxidase family protein 0.0471 0.4217 0.4217
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.003 0.0146 0.0114
Schistosoma mansoni hypothetical protein 0.0379 0.3365 0.3365
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0129 0.1055 0.1026
Toxoplasma gondii peptidylprolyl isomerase 0.003 0.0146 0.0105
Onchocerca volvulus 0.0027 0.0113 0.0268
Trypanosoma cruzi heat shock protein 85, putative 0.006 0.0423 0.0392
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0042 0.0297
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.1097 1 1
Brugia malayi Hsp90 protein 0.0025 0.0095 0.0095
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0029 0.0132 0.0132
Echinococcus multilocularis lamin 0.0027 0.0118 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.1264 0.1264
Plasmodium falciparum heat shock protein 90 0.006 0.0423 0.0339
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0088 0.0055
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0132
Schistosoma mansoni endoplasmin 0.006 0.0423 0.0423
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0129 0.1055 0.1055
Plasmodium falciparum heat shock protein 90, putative 0.0025 0.0095 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0032 0.0032
Echinococcus granulosus acetylcholinesterase 0.0114 0.0923 0.0923
Onchocerca volvulus Cytochrome c oxidase subunit 1 homolog 0.0077 0.0576 0.1365
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0362 0.0362
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0044 0.0276 0.019
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0042 0.0009
Plasmodium falciparum metacaspase 1 0.0049 0.0321 0.0236
Leishmania major hypothetical protein, conserved 0.004 0.0241 0.0209
Onchocerca volvulus 0.0044 0.0276 0.0655
Loa Loa (eye worm) hypothetical protein 0.0471 0.4217 0.4217
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0042 0.0009
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0088 0.0088
Trypanosoma cruzi metacaspase, putative 0.0049 0.0321 0.029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0118
Schistosoma mansoni cpg binding protein 0.0028 0.0127 0.0127
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0241 0.0241
Brugia malayi cytochrome c oxidase subunit I 0.0031 0.0158 0.0158
Echinococcus multilocularis protein quaking 0.0025 0.01 0.01
Brugia malayi Cytochrome P450 family protein 0.0019 0.0042 0.0042
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.1097 1 1
Schistosoma mansoni survival motor neuron protein 0.0045 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0133 0.1098 0.1098
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0044 0.0276 0.019
Leishmania major importin beta-1 subunit, putative 0.0026 0.011 0.0078
Trypanosoma brucei Metacaspase-4 0.0049 0.0321 0.029
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.004 0.0241 0.0241
Trypanosoma cruzi Heat shock protein 83, putative 0.006 0.0423 0.0392
Echinococcus multilocularis dna polymerase eta 0.0041 0.025 0.025
Schistosoma mansoni hypothetical protein 0.0029 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0167 0.0167
Echinococcus multilocularis lamin dm0 0.0027 0.0118 0.0118
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0132 0.0132
Echinococcus multilocularis acetylcholinesterase 0.0114 0.0923 0.0923
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0321 0.1548
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0042 0.0009
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0042 0.0297

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 134 mg kg-1 Antagonistic activity against apomorphine induced climbing in the mouse after po administration ChEMBL. 10464021
ED50 (functional) = 134 mg kg-1 Antagonistic activity against apomorphine induced climbing in the mouse after po administration ChEMBL. 10464021
ED50 (functional) = 775 mg kg-1 The compound was tested in vivo for induction of catalepsy in rat after ip administration ChEMBL. 10464021
Ki (binding) = 113 nM Binding affinity of the compound to the dopamine receptor D2L in rat brain membranes ChEMBL. 10464021
Ki (binding) = 113 nM Binding affinity of the compound to the dopamine receptor D2L in rat brain membranes ChEMBL. 10464021
Ki (binding) > 500 nM Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligand ChEMBL. 10464021
Ki (binding) > 500 nM Binding affinity towards Alpha-1 adrenergic receptor in human cortex membranes ChEMBL. 10464021
Ki (binding) > 500 nM Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligand ChEMBL. 10464021
Ki (binding) > 500 nM Binding affinity towards Alpha-1 adrenergic receptor in human cortex membranes ChEMBL. 10464021

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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