Detailed information for compound 200484

Basic information

Technical information
  • TDR Targets ID: 200484
  • Name: (2S)-5-(diaminomethylideneamino)-2-[[(2S)-3-p henyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]p ropanoyl]amino]pentanoic acid
  • MW: 418.49 | Formula: C20H30N6O4
  • H donors: 6 H acceptors: 4 LogP: -2.1 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=N)NCCC[C@@H](C(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1
  • InChi: 1S/C20H30N6O4/c21-20(22)24-11-5-9-15(19(29)30)25-18(28)16(12-13-6-2-1-3-7-13)26-17(27)14-8-4-10-23-14/h1-3,6-7,14-16,23H,4-5,8-12H2,(H,25,28)(H,26,27)(H,29,30)(H4,21,22,24)/t14-,15-,16-/m0/s1
  • InChiKey: LGMBKOAPPTYKLC-JYJNAYRXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-5-guanidino-2-[[(2S)-3-phenyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]amino]pentanoic acid
  • (2S)-5-guanidino-2-[[(2S)-1-oxo-2-[[oxo-[(2S)-2-pyrrolidinyl]methyl]amino]-3-phenylpropyl]amino]pentanoic acid
  • (2S)-5-[bis(azanyl)methylideneamino]-2-[[(2S)-3-phenyl-2-[[(2S)-pyrrolidin-2-yl]carbonylamino]propanoyl]amino]pentanoic acid
  • (2S)-5-guanidino-2-[[(2S)-3-phenyl-2-[[(2S)-prolyl]amino]propanoyl]amino]valeric acid
  • (2S)-5-guanidino-2-[[(2S)-3-phenyl-2-(prolylamino)propanoyl]amino]valeric acid
  • (2S)-5-(diaminomethylideneamino)-2-[[(2S)-3-phenyl-2-[[(2S)-pyrrolidin-2-yl]carbonylamino]propanoyl]amino]pentanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0026 0.0029 0.0083
Brugia malayi hypothetical protein 0.0055 0.0112 0.0131
Trypanosoma brucei histone deacetylase, putative 0.0401 0.1109 0.9726
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0023 0.0026
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0043 0.0079 0.0662
Echinococcus granulosus survival motor neuron protein 1 0.0264 0.0714 0.0833
Mycobacterium leprae PROBABLE HYDROLASE 0.0117 0.0292 0.3698
Brugia malayi Matrixin family protein 0.0096 0.0232 0.027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0109 0.0268 0.0313
Mycobacterium ulcerans thioesterase TesA 0.0033 0.0049 0.0491
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0035 0.0056 0.0457
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0249 0.067 0.23
Leishmania major cathepsin L-like protease 0.0337 0.0924 0.8101
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0038 0.0063 0.0468
Leishmania major carnitine/choline acetyltransferase, putative 0.0035 0.0056 0.0457
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0063 0.0525
Trichomonas vaginalis penicillin-binding protein, putative 0.0161 0.0418 0.0396
Echinococcus multilocularis cathepsin L 0.0042 0.0075 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0042 0.0075 0.0053
Mycobacterium leprae conserved hypothetical protein 0.0161 0.0418 0.5426
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0038 0.0063 0.0525
Giardia lamblia Cathepsin L precursor 0.0042 0.0075 0.0634
Brugia malayi Papain family cysteine protease containing protein 0.0117 0.0292 0.034
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0043 0.0079 0.0662
Mycobacterium leprae Probable polyketide synthase Pks1 0.0042 0.0075 0.0706
Plasmodium vivax vivapain-3 0.0117 0.0292 0.2549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0126 0.0104
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0106 0.0124
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.009 0.0212 0.019
Trypanosoma cruzi oligopeptidase b 0.0164 0.0426 0.3716
Entamoeba histolytica hypothetical protein 0.0026 0.003 0.007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1029 0.2915 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0412 0.114 0.133
Echinococcus multilocularis zinc finger protein 0.0028 0.0034 0.004
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0042 0.0075 0.0577
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0032 0.0009
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0009 0.0011
Trichomonas vaginalis glutathione reductase, putative 0.0038 0.0063 0.0041
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0042 0.0075 0.0577
Brugia malayi fibroinase precursor 0.0042 0.0075 0.0088
Schistosoma mansoni pyruvate kinase 0.0039 0.0066 0.0077
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0032 0.0038
Brugia malayi prolyl oligopeptidase family protein 0.0043 0.0079 0.0092
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0032 0.0037
Echinococcus multilocularis ceramide glucosyltransferase 0.0331 0.0907 0.1058
Mycobacterium leprae Probable lipase LipE 0.0161 0.0418 0.5426
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0104 0.0253 0.0295
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0023 0.0098
Toxoplasma gondii cathepsin CPL 0.0227 0.0609 0.5291
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0023 0.0108
Plasmodium vivax hypothetical protein, conserved 0.0161 0.0418 0.3699
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0042 0.0075 0.0577
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.009 0.0212 0.019
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0039 0.0068 0.0231
Loa Loa (eye worm) hypothetical protein 0.0068 0.0151 0.0176
Echinococcus granulosus Dipeptidyl peptidase 9 0.0043 0.0079 0.0092
Schistosoma mansoni hypothetical protein 0.0017 0.0004 0.0004
Toxoplasma gondii ABC1 family protein 0.0161 0.0418 0.3599
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0163 0.019
Schistosoma mansoni brca1-associated protein (brap2) 0.0027 0.0032 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Trypanosoma cruzi oligopeptidase b 0.0164 0.0426 0.3716
Giardia lamblia Alanyl dipeptidyl peptidase 0.0043 0.0079 0.067
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.009 0.0212 0.0248
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0038 0.0063 0.0525
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0032 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0227 0.0609 0.0588
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0059 0.0069
Plasmodium vivax unspecified product 0.0075 0.0171 0.1449
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0042 0.0075 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0393 0.0371
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0262 0.0708 0.6198
Echinococcus multilocularis histone deacetylase 7 0.0401 0.1109 0.1294
Loa Loa (eye worm) hypothetical protein 0.0039 0.0066 0.0077
Toxoplasma gondii cathepsin CPC2 0.0042 0.0075 0.0563
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0042 0.0075 0.0634
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0038 0.0063 0.0856
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0039 0.0068 0.0231
Loa Loa (eye worm) hypothetical protein 0.0168 0.0438 0.0511
Schistosoma mansoni hypothetical protein 0.0344 0.0943 0.11
Loa Loa (eye worm) fibroinase 0.0227 0.0609 0.071
Brugia malayi beta-lactamase 0.0161 0.0418 0.0487
Plasmodium vivax histone deacetylase 1, putative 0.0367 0.1011 0.9107
Onchocerca volvulus 0.0068 0.0151 0.1003
Echinococcus multilocularis histone deacetylase 6 0.0401 0.1109 0.1294
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0027 0.0031 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0042 0.0075 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0042 0.0075 0.0053
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0027 0.0031 0.0175
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0088 0.0102
Giardia lamblia Alanyl dipeptidyl peptidase 0.0043 0.0079 0.067
Loa Loa (eye worm) hypothetical protein 0.0161 0.0418 0.0487
Brugia malayi cathepsin L-like precursor 0.0152 0.0393 0.0458
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0059 0.0069
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0042 0.0075 0.0577
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0227 0.0609 0.071
Plasmodium falciparum glutathione reductase 0.0109 0.0268 0.2338
Leishmania major cathepsin L-like protease 0.0337 0.0924 0.8101
Plasmodium falciparum serine repeat antigen 9 0.0042 0.0075 0.0577
Plasmodium vivax histone deacetylase 2, putative 0.0401 0.1109 1
Trypanosoma cruzi cysteine peptidase, putative 0.0337 0.0924 0.8101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0381 0.0445
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0027 0.0032 0.018
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0369 0.1016 0.3485
Echinococcus multilocularis pyruvate kinase 0.0039 0.0066 0.0077
Brugia malayi Cathepsin L-like precursor 0.0152 0.0393 0.0458
Leishmania major hypothetical protein, conserved 0.0055 0.0112 0.0956
Schistosoma mansoni hypothetical protein 0.0023 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0079 0.0182 0.0212
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0151 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Plasmodium falciparum glutathione reductase 0.0038 0.0063 0.0468
Brugia malayi hypothetical protein 0.0264 0.0714 0.0833
Schistosoma mansoni cpg binding protein 0.0037 0.006 0.007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0031 0.0244
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0042 0.0075 0.0577
Plasmodium falciparum serine repeat antigen 1 0.0042 0.0075 0.0577
Brugia malayi prolyl oligopeptidase family protein 0.0043 0.0079 0.0092
Toxoplasma gondii hypothetical protein 0.0043 0.0079 0.0595
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0042 0.0075 0.0088
Entamoeba histolytica cysteine protease, putative 0.0042 0.0075 0.0532
Loa Loa (eye worm) fatty acid synthase 0.0039 0.0066 0.0077
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0249 0.067 0.8901
Giardia lamblia Hypothetical protein 0.0027 0.0032 0.0198
Trypanosoma cruzi histone deacetylase 1, putative 0.0367 0.1011 0.8864
Onchocerca volvulus 0.0161 0.0418 0.2767
Schistosoma mansoni alpha-glucosidase 0.0136 0.0346 0.0403
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0066 0.0552
Loa Loa (eye worm) hypothetical protein 0.0168 0.0438 0.0511
Echinococcus granulosus histone deacetylase 0.0401 0.1109 0.1294
Leishmania major pyruvate kinase 0.0039 0.0066 0.0552
Entamoeba histolytica histone deacetylase, putative 0.0367 0.1011 1
Schistosoma mansoni inositol monophosphatase 0.0027 0.0031 0.0037
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0126 0.2437
Loa Loa (eye worm) transcription factor SMAD2 0.006 0.0126 0.0148
Trichomonas vaginalis histone deacetylase, putative 0.0367 0.1011 0.0991
Echinococcus multilocularis snurportin 1 0.0344 0.0943 0.11
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0027 0.0032 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Leishmania major hypothetical protein, conserved 0.0161 0.0418 0.3644
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0035 0.0056 0.0457
Echinococcus multilocularis pyruvate kinase 0.002 0.0012 0.0014
Onchocerca volvulus 0.0046 0.0088 0.058
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0075 0.0171 0.0199
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0009 0.0011
Brugia malayi Muscleblind-like protein 0.0168 0.0438 0.0511
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0023 0.0098
Leishmania major histone deacetylase, putative 0.0367 0.1011 0.8864
Schistosoma mansoni importin beta-1 0.0032 0.0047 0.0055
Echinococcus granulosus cathepsin L cysteine protease 0.0117 0.0292 0.034
Brugia malayi histone deacetylase 11 0.0175 0.0456 0.0533
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.003 0.0228
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0055 0.0387
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.0381 0.0445
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0409 0.0477
Schistosoma mansoni histone deacetylase hda2 0.0175 0.0456 0.0533
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0066 0.0077
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0042 0.0075 0.0088
Brugia malayi histone deacetylase 1 (HD1) 0.0367 0.1011 0.118
Loa Loa (eye worm) hypothetical protein 0.0042 0.0075 0.0088
Echinococcus granulosus inositol monophosphatase 1 0.0027 0.0031 0.0037
Plasmodium vivax unspecified product 0.0042 0.0075 0.0577
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0227 0.0609 0.071
Mycobacterium ulcerans polyketide synthase Pks13 0.0059 0.0124 0.2377
Echinococcus granulosus ceramide glucosyltransferase 0.0331 0.0907 0.1058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0075 0.0053
Trypanosoma cruzi cysteine peptidase, putative 0.0337 0.0924 0.8101
Trypanosoma cruzi histone deacetylase, putative 0.0175 0.0456 0.3984
Mycobacterium ulcerans polyketide synthase 0.0042 0.0075 0.1143
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0126 0.1077
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0088 0.058
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0059 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Mycobacterium ulcerans Type I modular polyketide synthase 0.0039 0.0068 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0042 0.0075 0.0634
Mycobacterium ulcerans polyketide synthase 0.0039 0.0068 0.0966
Leishmania major cathepsin L-like protease 0.0227 0.0609 0.5325
Plasmodium falciparum peptidase, putative 0.0043 0.0079 0.061
Loa Loa (eye worm) hypothetical protein 0.0049 0.0097 0.0113
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0032 0.0009
Echinococcus granulosus histone deacetylase 6 0.0428 0.1186 0.1384
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0059 0.0491
Brugia malayi cathepsin Z-like cysteine proteinase 0.0042 0.0075 0.0088
Loa Loa (eye worm) histone deacetylase 11 0.0175 0.0456 0.0533
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0112 0.0915
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0609 0.071
Trichomonas vaginalis D-aminoacylase, putative 0.0161 0.0418 0.0396
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0027 0.0032 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Giardia lamblia Cathepsin L precursor 0.0042 0.0075 0.0634
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0381 0.0445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0039 0.0068 0.0966
Echinococcus granulosus snurportin 1 0.0344 0.0943 0.11
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0059 0.0069
Toxoplasma gondii histone deacetylase HDAC1 0.0401 0.1109 0.9724
Mycobacterium leprae Polyketide synthase Pks13 0.0059 0.0124 0.1379
Echinococcus multilocularis cathepsin L 0.0117 0.0292 0.034
Brugia malayi Cathepsin L-like precursor 0.0227 0.0609 0.071
Trichomonas vaginalis inositol monophosphatase, putative 0.0027 0.0031 0.0009
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2535 0.7248 0.8456
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0042 0.0075 0.0634
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.0381 0.0445
Loa Loa (eye worm) hypothetical protein 0.0096 0.0232 0.027
Giardia lamblia Cathepsin L precursor 0.0042 0.0075 0.0634
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0164 0.0427 0.0499
Brugia malayi beta-lactamase family protein 0.0161 0.0418 0.0487
Onchocerca volvulus 0.0161 0.0418 0.2767
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0032 0.018
Brugia malayi Carboxylesterase family protein 0.0068 0.0151 0.0176
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0164 0.0426 1
Mycobacterium ulcerans hypothetical protein 0.009 0.0212 0.4613
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.0292 0.2533
Toxoplasma gondii histone deacetylase HDAC4 0.0175 0.0456 0.3941
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.0292 0.027
Plasmodium falciparum importin beta, putative 0.0032 0.0047 0.0321
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0056 0.0457
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Giardia lamblia Cysteine protease 0.0042 0.0075 0.0634
Mycobacterium tuberculosis Probable lipase LipE 0.0161 0.0418 0.1433
Plasmodium falciparum cysteine proteinase falcipain 1 0.0117 0.0292 0.2549
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0032 0.0038
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0027 0.0032 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0075 0.0053
Entamoeba histolytica cysteine protease, putative 0.0042 0.0075 0.0532
Mycobacterium ulcerans lipase LipD 0.0161 0.0418 0.9792
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0043 0.0079 0.0092
Echinococcus granulosus beta LACTamase domain containing family member 0.0161 0.0418 0.0487
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0023 0.0167
Brugia malayi cathepsin Z-like cysteine proteinase 0.0042 0.0075 0.0088
Giardia lamblia Cysteine protease 0.0042 0.0075 0.0634
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0079 0.0662
Onchocerca volvulus Matrilysin homolog 0.0214 0.0569 0.3771
Brugia malayi cathepsin L precursor 0.0042 0.0075 0.0088
Echinococcus granulosus histone deacetylase 7 0.0401 0.1109 0.1294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Echinococcus multilocularis pyruvate kinase 0.002 0.0012 0.0014
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.009 0.0212 0.1836
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0027 0.0032 0.0091
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0088 0.0102
Loa Loa (eye worm) prolyl oligopeptidase 0.0043 0.0079 0.0092
Echinococcus granulosus importin subunit beta 1 0.0032 0.0047 0.0055
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0042 0.0075 0.063
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0059 0.0491
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0066 0.0077
Onchocerca volvulus 0.0163 0.0422 0.2795
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0096 0.0112
Toxoplasma gondii preprocathepsin c precursor, putative 0.0042 0.0075 0.0563
Trichomonas vaginalis histone deacetylase, putative 0.0367 0.1011 0.0991
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0042 0.0075 0.0255
Brugia malayi Matrixin family protein 0.0096 0.0232 0.027
Leishmania major cathepsin L-like protease 0.0227 0.0609 0.5325
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0541 0.151 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0164 0.0426 0.3716
Echinococcus granulosus cathepsin l cysteine peptidase 0.0227 0.0609 0.071
Loa Loa (eye worm) hypothetical protein 0.0161 0.0418 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0032 0.0046 0.0409
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0027 0.0032 0.0037
Trichomonas vaginalis BRCA1-associated protein, putative 0.0027 0.0032 0.0009
Loa Loa (eye worm) hypothetical protein 0.0152 0.0393 0.0458
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0126 0.0147
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0331 0.0907 0.6009
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.006 0.007
Trichomonas vaginalis histone deacetylase, putative 0.0367 0.1011 0.0991
Plasmodium falciparum serine repeat antigen 7 0.0042 0.0075 0.0577
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0099 0.0793
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0126 0.1077
Brugia malayi prolyl oligopeptidase family protein 0.0043 0.0079 0.0092
Loa Loa (eye worm) histone deacetylase 0.0401 0.1109 0.1294
Trichomonas vaginalis mercuric reductase, putative 0.0038 0.0063 0.0041
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0126 0.0431
Loa Loa (eye worm) MBCTL1 0.0053 0.0106 0.0124
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0059 0.0433
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0027 0.0032 0.018
Leishmania major cathepsin L-like protease 0.0227 0.0609 0.5325
Brugia malayi Cathepsin L-like precursor 0.0227 0.0609 0.071
Brugia malayi CXXC zinc finger family protein 0.0033 0.0049 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0039 0.0068 0.061
Loa Loa (eye worm) hypothetical protein 0.0244 0.0655 0.0764
Giardia lamblia Cathepsin B precursor 0.0042 0.0075 0.0634
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0027 0.0032 0.0037
Entamoeba histolytica cysteine proteinase 1, putative 0.0117 0.0292 0.2721
Entamoeba histolytica steroid 5-alpha reductase, putative 0.009 0.0212 0.1919
Trypanosoma cruzi cysteine proteinase, putative 0.0117 0.0292 0.2533
Echinococcus granulosus pyruvate kinase 0.002 0.0012 0.0014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0126 0.104
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.0679 0.0792
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0032 0.0046 0.0306
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0055 0.0033
Leishmania major GTP-binding protein, putative 0.0024 0.0023 0.0167
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0126 0.1046
Plasmodium falciparum pyruvate kinase 0.0039 0.0066 0.0496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0075 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0059 0.0069
Entamoeba histolytica cysteine protease, putative 0.0042 0.0075 0.0532
Loa Loa (eye worm) acetyltransferase 0.0164 0.0427 0.0499
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0164 0.0427 0.0499
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0066 0.0077
Toxoplasma gondii histone deacetylase HDAC5 0.0175 0.0456 0.3941
Mycobacterium tuberculosis Conserved protein 0.0161 0.0418 0.1433
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0126 0.0147
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0292 0.034
Trichomonas vaginalis D-aminoacylase, putative 0.0161 0.0418 0.0396
Trypanosoma cruzi histone deacetylase, putative 0.0175 0.0456 0.3984
Trypanosoma brucei histone deacetylase 3 0.0401 0.1109 0.9726
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0043 0.0079 0.0092
Loa Loa (eye worm) ctsf protein 0.0227 0.0609 0.071
Schistosoma mansoni choline o-acyltransferase 0.0035 0.0056 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0126 0.0148
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0009 0.0011
Brugia malayi PHD-finger family protein 0.0034 0.0051 0.006
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0128 0.0322 0.0376
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Loa Loa (eye worm) hypothetical protein 0.0055 0.0112 0.0131
Onchocerca volvulus Cathepsin L homolog 0.0042 0.0075 0.0498
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0027 0.0032 0.0037
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0027 0.0032 0.0037
Onchocerca volvulus Fatty acid synthase homolog 0.0071 0.0158 0.105
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0031 0.0009
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0088 0.0102
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.007 0.0082
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0036
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0024 0.0023 0.0079
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0106 0.0124
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0042 0.0075 0.063
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0043 0.0079 0.0595
Giardia lamblia Cysteine protease 0.0042 0.0075 0.0634
Loa Loa (eye worm) hypothetical protein 0.0042 0.0075 0.0088
Schistosoma mansoni histone deacetylase 1 2 3 0.0175 0.0456 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0075 0.0053
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0038 0.0063 0.0468
Echinococcus granulosus phospholipase D 0.0028 0.0034 0.004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0039 0.0068 0.0966
Loa Loa (eye worm) matrix metalloproteinase 0.0096 0.0232 0.027
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0042 0.0075 0.0706
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0117 0.0292 0.1002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0161 0.0418 0.1433
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0038 0.0064 0.0219
Echinococcus granulosus cathepsin L cysteine proteinase 0.0227 0.0609 0.071
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0075 0.0169 0.0197
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0038 0.0063 0.0856
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0043 0.0079 0.0092
Giardia lamblia Hypothetical protein 0.0042 0.0075 0.0634
Echinococcus multilocularis pyruvate kinase 0.0031 0.0043 0.005
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.1374 0.1603
Brugia malayi hypothetical protein 0.0035 0.0056 0.0066
Plasmodium falciparum serine repeat antigen 5 0.0042 0.0075 0.0577
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0066 0.0591
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0249 0.067 0.23
Brugia malayi Cathepsin L-like cysteine proteinase 0.0152 0.0393 0.0458
Toxoplasma gondii cathepsin B 0.0042 0.0075 0.0563
Leishmania major telomerase reverse transcriptase, putative 0.0148 0.0379 0.3305
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.009 0.0212 0.1778
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0066 0.0552
Mycobacterium tuberculosis Probable dehydrogenase 0.0249 0.067 0.23
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0042 0.0075 0.0577
Trypanosoma cruzi prolyl endopeptidase 0.0412 0.114 1
Echinococcus multilocularis cathepsin b 0.0042 0.0075 0.0088
Echinococcus granulosus pyruvate kinase 0.002 0.0012 0.0014
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0059 0.0423
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0042 0.0075 0.0255
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0112 0.0915
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0066 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0381 0.0445
Brugia malayi Bromodomain containing protein 0.0047 0.0089 0.0104
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0088 0.0102
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0038 0.0063 0.0525
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0038 0.0063 0.0525
Echinococcus granulosus acetylcholinesterase 0.0068 0.0151 0.0176
Entamoeba histolytica cysteine protease, putative 0.0042 0.0075 0.0532
Brugia malayi Papain family cysteine protease containing protein 0.0042 0.0075 0.0088
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0035 0.0056 0.0457
Loa Loa (eye worm) hypothetical protein 0.0175 0.0456 0.0533
Mycobacterium ulcerans beta-lactamase 0.0161 0.0418 0.9792
Trypanosoma cruzi cysteine peptidase, putative 0.0227 0.0609 0.5325
Trypanosoma cruzi histone deacetylase, putative 0.0401 0.1109 0.9726
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0027 0.0032 0.0037
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0027 0.0032 0.0177
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Giardia lamblia Cathepsin B precursor 0.0042 0.0075 0.0634
Loa Loa (eye worm) inositol-1 0.0027 0.0031 0.0037
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0031 0.0009
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0042 0.0075 0.0088
Mycobacterium ulcerans thioesterase 0.0033 0.0049 0.0491
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0161 0.0418 0.1433
Brugia malayi BRCA1-associated protein 2 containing protein 0.0027 0.0032 0.0037
Giardia lamblia Cathepsin L precursor 0.0042 0.0075 0.0634
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0027 0.0032 0.0037
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0043 0.0079 0.0662
Onchocerca volvulus 0.0227 0.0609 0.4033
Giardia lamblia Cathepsin L precursor 0.0042 0.0075 0.0634
Onchocerca volvulus 0.0035 0.0056 0.0368
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0043 0.0079 0.0092
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0059 0.0069
Echinococcus granulosus acetylcholinesterase 0.0068 0.0151 0.0176
Onchocerca volvulus Cathepsin L homolog 0.0227 0.0609 0.4033
Echinococcus granulosus pyruvate kinase 0.0039 0.0066 0.0077
Giardia lamblia Cathepsin L-like protease 0.0042 0.0075 0.0634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Loa Loa (eye worm) hypothetical protein 0.0053 0.0108 0.0126
Trypanosoma cruzi trypanothione reductase, putative 0.0109 0.0268 0.2329
Schistosoma mansoni cellular tumor antigen P53 0.0163 0.0422 0.0492
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0047 0.0382
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0042 0.0075 0.0577
Trypanosoma cruzi cysteine peptidase, putative 0.0337 0.0924 0.8101
Brugia malayi Papain family cysteine protease containing protein 0.0042 0.0075 0.0088
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0038 0.0063 0.0457
Plasmodium falciparum serine repeat antigen 6 0.0042 0.0075 0.0577
Leishmania major carnitine palmitoyltransferase-like protein 0.0104 0.0253 0.2194
Trypanosoma brucei cysteine peptidase C (CPC) 0.0042 0.0075 0.063
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0032 0.0047 0.0161
Plasmodium vivax glutathione reductase, putative 0.0109 0.0268 0.2338
Mycobacterium ulcerans Type I modular polyketide synthase 0.0039 0.0068 0.0966
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0043 0.0079 0.0662
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0011 0.0013
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0038 0.0063 0.0074
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0011 0.0013
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.2996 0.8571 1
Brugia malayi prolyl oligopeptidase family protein 0.0043 0.0079 0.0092
Trypanosoma brucei histone deacetylase 2 0.0175 0.0456 0.3984
Loa Loa (eye worm) thioredoxin reductase 0.0109 0.0268 0.0313
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0161 0.0418 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Loa Loa (eye worm) histone deacetylase 7A 0.0401 0.1109 0.1294
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0056 0.0457
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Toxoplasma gondii histone deacetylase HDAC3 0.0367 0.1011 0.8856
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0409 0.0477
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0151 0.0176
Plasmodium vivax vivapain-1 0.0117 0.0292 0.2549
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0042 0.0075 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0155 0.018
Trichomonas vaginalis esterase, putative 0.0161 0.0418 0.0396
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0042 0.0075 0.0088
Echinococcus multilocularis pyruvate kinase 0.002 0.0012 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0292 0.2721
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.009 0.0212 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0063 0.0525
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0161 0.0418 0.1433
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0032 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0096 0.0112
Loa Loa (eye worm) hypothetical protein 0.0152 0.0393 0.0458
Plasmodium falciparum cysteine proteinase falcipain 3 0.0227 0.0609 0.5441
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0038 0.0063 0.0216
Echinococcus granulosus histone deacetylase 6 0.0401 0.1109 0.1294
Echinococcus granulosus geminin 0.0359 0.0987 0.1151
Echinococcus multilocularis histone deacetylase 3 0.0367 0.1011 0.118
Brugia malayi beta-lactamase family protein 0.0161 0.0418 0.0487
Loa Loa (eye worm) hypothetical protein 0.0227 0.0609 0.071
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Toxoplasma gondii prolyl endopeptidase 0.0412 0.114 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0079 0.061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0038 0.0063 0.0525
Echinococcus granulosus muscleblind protein 0.0168 0.0438 0.0511
Loa Loa (eye worm) hypothetical protein 0.0163 0.0422 0.0492
Onchocerca volvulus 0.0137 0.0348 0.2302
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0032 0.0247
Schistosoma mansoni cathepsin F (C01 family) 0.0227 0.0609 0.071
Onchocerca volvulus 0.0035 0.0056 0.0368
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0042 0.0075 0.0088
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0028 0.0034 0.004
Toxoplasma gondii histone deacetylase HDAC2 0.0367 0.1011 0.8856
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0292 0.2721
Schistosoma mansoni cathepsin B (C01 family) 0.0042 0.0075 0.0088
Brugia malayi Cytochrome P450 family protein 0.0021 0.0014 0.0017
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0059 0.0491
Brugia malayi MH2 domain containing protein 0.006 0.0126 0.0148
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.006
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0104 0.0253 0.0295
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0148 0.0379 0.3305
Schistosoma mansoni histone deacetylase 0.0367 0.1011 0.118
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0164 0.0426 0.1461
Onchocerca volvulus 0.0033 0.0049 0.0324
Loa Loa (eye worm) hypothetical protein 0.009 0.0212 0.0248
Echinococcus granulosus cathepsin L 0.0042 0.0075 0.0088
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0112 0.0891
Onchocerca volvulus 0.0096 0.0232 0.1535
Brugia malayi Cathepsin L-like precursor 0.0227 0.0609 0.071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0467 0.1299 0.1515
Schistosoma mansoni brca1-associated protein (brap2) 0.0027 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0055
Onchocerca volvulus 0.0054 0.0109 0.0724
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0055 0.0033
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0043 0.0079 0.0056
Giardia lamblia Cathepsin B precursor 0.0042 0.0075 0.0634
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0098 0.0236 0.2042
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0047 0.0314
Brugia malayi Histone deacetylase 1 0.0367 0.1011 0.118
Schistosoma mansoni histone deacetylase 0.0367 0.1011 0.118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0038 0.0063 0.0525
Entamoeba histolytica prolyl oligopeptidase family protein 0.0043 0.0079 0.0569
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0059 0.0069
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0043 0.0079 0.0092
Mycobacterium tuberculosis Conserved protein 0.0161 0.0418 0.1433
Echinococcus multilocularis prolyl endopeptidase 0.0412 0.114 0.133
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.006 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0063 0.0525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.0292 0.2533
Brugia malayi Matrixin family protein 0.0096 0.0232 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0079 0.0662
Giardia lamblia Cathepsin L precursor 0.0042 0.0075 0.0634
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0292 0.034
Brugia malayi Papain family cysteine protease containing protein 0.0117 0.0292 0.034
Echinococcus granulosus histone deacetylase 6 0.0401 0.1109 0.1294
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.008 0.0681
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0055 0.0455
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0055 0.0033
Toxoplasma gondii cathepsin CPC1 0.0042 0.0075 0.0563
Leishmania major cathepsin L-like protease 0.0227 0.0609 0.5325
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0112 0.0915
Schistosoma mansoni cathepsin C 0.0042 0.0075 0.0088
Brugia malayi prolyl oligopeptidase family protein 0.0412 0.114 0.133
Mycobacterium tuberculosis Probable peptidase 0.0164 0.0426 0.1461
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0027 0.0032 0.0177
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0161 0.0418 0.0487
Plasmodium falciparum histone deacetylase, putative 0.0401 0.1109 1
Echinococcus multilocularis muscleblind protein 0.0168 0.0438 0.0511
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0027 0.0032 0.0247
Brugia malayi Cathepsin L-like precursor 0.0227 0.0609 0.071
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0126 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0032 0.0037
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0043 0.0079 0.0662
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0032 0.0046 0.0409
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0277 0.075 0.2574
Plasmodium falciparum histone deacetylase 2 0.0401 0.1109 1
Loa Loa (eye worm) hypothetical protein 0.0412 0.114 0.133
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0035 0.0056 0.0457
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0098 0.0236 0.2042
Schistosoma mansoni phospholipase D 0.0031 0.0045 0.0053
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0088 0.0102
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0104 0.0253 0.0295
Onchocerca volvulus 0.0227 0.0609 0.4033
Onchocerca volvulus 0.0227 0.0609 0.4033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.0381 0.0445
Toxoplasma gondii exonuclease III APE 0.006 0.0126 0.1013
Loa Loa (eye worm) hypothetical protein 0.0254 0.0684 0.0798
Brugia malayi cathepsin F-like cysteine proteinase 0.0042 0.0075 0.0088
Schistosoma mansoni hypothetical protein 0.0054 0.0109 0.0128
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.0513 0.0599
Plasmodium falciparum histone deacetylase 1 0.0367 0.1011 0.9107
Loa Loa (eye worm) hypothetical protein 0.0042 0.0075 0.0088
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0109 0.0128
Giardia lamblia Hypothetical protein 0.0042 0.0075 0.0634
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0098 0.0236 0.0275
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0038 0.0063 0.0856
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0066 0.0439
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0059 0.0491
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0027 0.0032 0.0091
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0042 0.0075 0.1143
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0055 0.0033
Loa Loa (eye worm) carboxylesterase 0.0068 0.0151 0.0176
Plasmodium falciparum thioredoxin reductase 0.0038 0.0063 0.0468
Brugia malayi Histone deacetylase family protein 0.0401 0.1109 0.1294
Onchocerca volvulus 0.0152 0.0393 0.26
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0126 0.0147
Leishmania major cathepsin L-like protease 0.0227 0.0609 0.5325
Brugia malayi Telomerase reverse transcriptase 0.0393 0.1085 0.1266
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0227 0.0609 0.5441
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0277 0.075 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0265 0.0718 0.0837
Schistosoma mansoni hypothetical protein 0.0034 0.0051 0.006
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0032 0.0038
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0066 0.0077
Loa Loa (eye worm) hypothetical protein 0.0049 0.0096 0.0112
Echinococcus granulosus cathepsin l1 0.0227 0.0609 0.071
Brugia malayi Cathepsin L-like precursor 0.0227 0.0609 0.071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0126 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0102
Entamoeba histolytica prolyl oligopeptidase family protein 0.0043 0.0079 0.0569
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0031 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0075 0.0053
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0055 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0171 0.1471
Giardia lamblia Cathepsin B precursor 0.0042 0.0075 0.0634
Echinococcus granulosus BRCA1 associated protein 0.0027 0.0032 0.0037
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0088 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.0292 0.2533
Loa Loa (eye worm) matrixin family protein 0.0214 0.0569 0.0664
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0066 0.0439
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.0513 0.0599
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0055 0.0331
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.0393 0.3742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0075 0.0053
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0042 0.0075 0.063
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0032 0.0009
Brugia malayi Phospholipase A2 family protein 0.012 0.0301 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0075 0.0053
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0059 0.0124 0.0423
Echinococcus granulosus cathepsin b 0.0042 0.0075 0.0088
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0009 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0042 0.0075 0.0053
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0151 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0016
Trypanosoma brucei prolyl endopeptidase 0.0412 0.114 1
Mycobacterium ulcerans esterase/lipase LipP 0.0161 0.0418 0.9792
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0035 0.0056 0.0457
Plasmodium vivax serine-repeat antigen (SERA) 0.0042 0.0075 0.0577
Giardia lamblia Cathepsin B precursor 0.0042 0.0075 0.0634
Schistosoma mansoni inositol monophosphatase 0.0027 0.0031 0.0037
Echinococcus multilocularis inositol monophosphatase 1 0.0027 0.0031 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0066 0.0932
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0027 0.0032 0.0037
Giardia lamblia Telomerase catalytic subunit 0.0148 0.0379 0.3677
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0098 0.0236 0.2042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0035 0.0056 0.0065
Brugia malayi Cathepsin L-like precursor 0.0227 0.0609 0.071
Onchocerca volvulus 0.0227 0.0609 0.4033
Plasmodium falciparum serine repeat antigen 4 0.0042 0.0075 0.0577
Echinococcus multilocularis histone deacetylase 6 0.0401 0.1109 0.1294
Plasmodium vivax unspecified product 0.0117 0.0292 0.2549
Giardia lamblia Cathepsin L-like protease 0.0042 0.0075 0.0634
Loa Loa (eye worm) hypothetical protein 0.0264 0.0714 0.0833
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0032 0.0009
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0023 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.0381 0.0445
Onchocerca volvulus 0.0035 0.0056 0.0368
Loa Loa (eye worm) hypothetical protein 0.0161 0.0418 0.0487
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0055 0.0065
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0032 0.0247
Loa Loa (eye worm) hypothetical protein 0.0035 0.0056 0.0065
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0043 0.0079 0.0569
Loa Loa (eye worm) hypothetical protein 0.0042 0.0075 0.0088
Echinococcus granulosus prolyl endopeptidase 0.0412 0.114 0.133
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Brugia malayi histone deacetylase 3 (HD3) 0.0367 0.1011 0.118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0277 0.075 0.2574
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0412 0.114 1
Echinococcus granulosus neuropeptide s receptor 0.0493 0.1374 0.1603
Brugia malayi mbt repeat family protein 0.0046 0.0088 0.0102
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0027 0.0032 0.0009
Echinococcus multilocularis pyruvate kinase 0.0039 0.0066 0.0077
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0059 0.0423
Trypanosoma cruzi cysteine proteinase, putative 0.0117 0.0292 0.2533
Echinococcus multilocularis histone deacetylase 8 0.0175 0.0456 0.0533
Loa Loa (eye worm) hypothetical protein 0.0075 0.0171 0.0199
Plasmodium vivax telomerase reverse transcriptase, putative 0.0148 0.0379 0.3349
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0112 0.0956
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.035 0.0962 0.1123
Echinococcus multilocularis phospholipase D1 0.0031 0.0045 0.0053
Schistosoma mansoni histone deacetylase hda2 0.0428 0.1186 0.1384
Leishmania major importin beta-1 subunit, putative 0.0026 0.003 0.0228
Giardia lamblia Pyruvate kinase 0.0039 0.0066 0.0545
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0098 0.0236 0.0275
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0042 0.0075 0.0255
Loa Loa (eye worm) cysteine protease 0.0227 0.0609 0.071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0092
Mycobacterium tuberculosis Probable esterase LipL 0.0161 0.0418 0.1433
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0337 0.0924 0.8101
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0099 0.0773
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0151 0.0176
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0227 0.0609 0.5441
Onchocerca volvulus Phospholipase A2 homolog 0.012 0.0301 0.1992
Trypanosoma brucei oligopeptidase b 0.0164 0.0426 0.3716
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0244 0.0655 0.0764
Trypanosoma brucei histone deacetylase 4 0.0401 0.1109 0.9726
Brugia malayi Thioredoxin reductase 0.0109 0.0268 0.0313
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0042 0.0075 0.0532
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0056 0.0457
Trypanosoma brucei telomerase reverse transcriptase 0.0148 0.0379 0.3305
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0126 0.0147
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0038 0.0063 0.0074
Schistosoma mansoni zinc finger protein 0.0017 0.0004 0.0004
Loa Loa (eye worm) cathepsin B 0.0042 0.0075 0.0088
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0035 0.0056 0.0457
Leishmania major pyruvate kinase 0.0039 0.0066 0.0552
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0043 0.0079 0.0595
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Onchocerca volvulus 0.0227 0.0609 0.4033
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0344 0.0943 0.11
Leishmania major hypothetical protein, conserved 0.0027 0.0032 0.0247
Giardia lamblia Histone deacetylase 0.0367 0.1011 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.035 0.0962 0.1123
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0109 0.0268 0.092
Loa Loa (eye worm) hypothetical protein 0.0161 0.0418 0.0487
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0112 0.0956
Echinococcus multilocularis tumor protein p63 0.111 0.3148 0.3673
Mycobacterium tuberculosis Probable lipase LipD 0.0161 0.0418 0.1433
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0091
Echinococcus granulosus histone deacetylase 3 0.0367 0.1011 0.118
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0117 0.0292 0.0341
Entamoeba histolytica cysteine proteinase 2 0.0117 0.0292 0.2721
Echinococcus granulosus cathepsin b 0.0042 0.0075 0.0088
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0409 0.0477
Echinococcus granulosus zinc finger protein 0.0028 0.0034 0.004
Leishmania major hypothetical protein, conserved 0.0027 0.0032 0.0247
Loa Loa (eye worm) hypothetical protein 0.0096 0.0232 0.027
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0117 0.0292 0.2533
Echinococcus multilocularis cathepsin L cysteine protease 0.0227 0.0609 0.071
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0031 0.0244
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.2996 0.8571 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0055 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0037 0.006 0.007
Schistosoma mansoni hypothetical protein 0.0359 0.0987 0.1151
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0038 0.0063 0.0525
Plasmodium vivax thioredoxin reductase, putative 0.0109 0.0268 0.2338
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0042 0.0075 0.1143
Echinococcus multilocularis beta LACTamase domain containing family member 0.0161 0.0418 0.0487
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0027 0.0032 0.0091
Echinococcus multilocularis survival motor neuron protein 1 0.0264 0.0714 0.0833
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.146 0.4153 0.4845
Loa Loa (eye worm) hypothetical protein 0.012 0.0301 0.0351
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0099 0.0115
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0026 0.0028 0.0144
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0055 0.0033
Echinococcus multilocularis BRCA1 associated protein 0.0027 0.0032 0.0037
Brugia malayi Inositol-1 0.0027 0.0031 0.0037
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0126 0.1142
Schistosoma mansoni ap endonuclease 0.006 0.0126 0.0147
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0066 0.0496
Echinococcus multilocularis cathepsin b 0.0042 0.0075 0.0088
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0038 0.0063 0.0525
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0038 0.0064 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0075 0.0053
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0027 0.0032 0.0198
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0023 0.0167
Loa Loa (eye worm) hypothetical protein 0.0152 0.0393 0.0458
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0043 0.0079 0.0662
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0038
Trypanosoma brucei histone deacetylase 1 0.0367 0.1011 0.8864
Loa Loa (eye worm) acyl carrier protein 0.0018 0.0007 0.0008
Onchocerca volvulus 0.0161 0.0418 0.2767
Trypanosoma cruzi histone deacetylase, putative 0.0401 0.1109 0.9726
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0011 0.0013
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0161 0.0418 0.0487
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0043 0.0079 0.0056
Onchocerca volvulus Phospholipase A2 homolog 0.012 0.0301 0.1992
Brugia malayi Cathepsin L-like precursor 0.0152 0.0393 0.0458
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0249 0.067 0.23
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0042 0.0075 0.0577
Loa Loa (eye worm) histone deacetylase 1 0.0367 0.1011 0.118
Entamoeba histolytica prolyl oligopeptidase family protein 0.0043 0.0079 0.0569
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0056 0.0457
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0032 0.0037
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0106 0.0124
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0027 0.0032 0.018
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0063 0.0525
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.0042 0.0075 0.0088
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.0079 0.0569
Leishmania major cysteine peptidase A (CPA) 0.0227 0.0609 0.5325
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0055 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0038 0.0063 0.0468
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0042 0.0075 0.0706
Onchocerca volvulus 0.0042 0.0075 0.0498
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0066 0.0077
Brugia malayi acetyltransferase, GNAT family protein 0.0164 0.0427 0.0499
Loa Loa (eye worm) hypothetical protein 0.0227 0.0607 0.0708
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0021 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0292 0.2721
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0039 0.0068 0.0231
Schistosoma mansoni cathepsin F (C01 family) 0.0152 0.0393 0.0458
Trypanosoma brucei glucosidase, putative 0.0035 0.0055 0.0455
Plasmodium vivax histone deacetylase, putative 0.0401 0.1109 1
Echinococcus multilocularis cysteine protease 0.0227 0.0609 0.071
Loa Loa (eye worm) hypothetical protein 0.0068 0.0151 0.0176
Plasmodium falciparum serine repeat antigen 3 0.0042 0.0075 0.0577
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0023 0.0026
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0042 0.0075 0.0532
Schistosoma mansoni cathepsin s 0.0075 0.0171 0.0199
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0023 0.0097
Schistosoma mansoni alpha glucosidase 0.0035 0.0055 0.0065
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0043 0.0079 0.0092
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.007 0.0082
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0042 0.0075 0.0088
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0106 0.0124
Schistosoma mansoni hypothetical protein 0.0025 0.0025 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0056 0.0457
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0032 0.01
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0023 0.0026
Echinococcus granulosus phospholipase D1 0.0031 0.0045 0.0053
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0163 0.019
Loa Loa (eye worm) matrixin family protein 0.0233 0.0625 0.0729
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0104 0.0253 0.2194
Brugia malayi follicle stimulating hormone receptor 0.0252 0.0679 0.0792
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0106 0.0124
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0126 0.1077
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0066 0.0044
Echinococcus granulosus cpg binding protein 0.0037 0.006 0.007
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0059 0.0124 0.0423
Loa Loa (eye worm) glutathione reductase 0.0109 0.0268 0.0313
Brugia malayi Ceramide glucosyltransferase 0.0331 0.0907 0.1058
Brugia malayi cathepsin L-like cysteine proteinase 0.0042 0.0075 0.0088
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0249 0.067 0.23
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0027 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.0075 0.0171 0.0199
Plasmodium vivax serine-repeat antigen (SERA) 0.0042 0.0075 0.0577
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0104 0.0253 0.2194
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0042 0.0075 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0059 0.0069
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Echinococcus multilocularis geminin 0.0359 0.0987 0.1151
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0038 0.0063 0.0525
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0035 0.0056 0.0457
Leishmania major histone deacetylase, putative 0.0401 0.1109 0.9726
Loa Loa (eye worm) ceramide glucosyltransferase 0.0331 0.0907 0.1058
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0059 0.0491
Plasmodium vivax vivapain-2 0.0227 0.0609 0.5441
Trypanosoma cruzi histone deacetylase 1, putative 0.0367 0.1011 0.8864
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0063 0.0525
Trypanosoma brucei trypanothione reductase 0.0109 0.0268 0.2329
Mycobacterium ulcerans hypothetical protein 0.0161 0.0418 0.9792
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0126 0.0104
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0059 0.0433
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0038 0.0063 0.0074
Schistosoma mansoni cpg binding protein 0.0037 0.006 0.007
Leishmania major oligopeptidase b 0.0164 0.0426 0.3716
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0092
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0409 0.0477
Schistosoma mansoni ran 0.0024 0.0023 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.0381 0.0445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Schistosoma mansoni bromodomain containing protein 0.0076 0.0174 0.0204
Trypanosoma cruzi cruzipain precursor, putative 0.0337 0.0924 0.8101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Brugia malayi Histone deacetylase family protein 0.0401 0.1109 0.1294
Schistosoma mansoni zinc finger protein 0.0028 0.0034 0.004
Echinococcus granulosus dnaJ subfamily B 0.0467 0.1299 0.1515
Schistosoma mansoni pyruvate kinase 0.002 0.0012 0.0014
Leishmania major trypanothione reductase 0.0109 0.0268 0.2329
Echinococcus granulosus tumor protein p63 0.111 0.3148 0.3673
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0027 0.0032 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0063 0.0525
Giardia lamblia Cathepsin B precursor 0.0042 0.0075 0.0634
Brugia malayi isocitrate dehydrogenase 0.0036 0.0059 0.0069
Echinococcus multilocularis cathepsin L cysteine protease 0.0227 0.0609 0.071
Entamoeba histolytica phospholipase D, putative 0.0031 0.0045 0.0227
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0152 0.1246
Schistosoma mansoni ceramide glucosyltransferase 0.0331 0.0907 0.1058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.0292 0.027
Loa Loa (eye worm) hypothetical protein 0.0096 0.0232 0.027
Entamoeba histolytica phospholipase D, putative 0.0031 0.0045 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0161 0.0418 0.3644
Schistosoma mansoni serine/threonine protein kinase 0.2996 0.8571 1
Echinococcus multilocularis choline O acetyltransferase 0.0035 0.0056 0.0065
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0104 0.0253 0.0295
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0042 0.0075 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0871 0.2459 0.2442
Chlamydia trachomatis pyruvate kinase 0.0039 0.0066 1
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0292 0.2721
Schistosoma mansoni cathepsin F (C01 family) 0.0227 0.0609 0.071
Loa Loa (eye worm) prolyl oligopeptidase 0.0043 0.0079 0.0092
Brugia malayi Carboxylesterase family protein 0.0068 0.0151 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0075 0.0053
Leishmania major cathepsin L-like protease 0.0337 0.0924 0.8101
Brugia malayi glutathione reductase 0.0109 0.0268 0.0313
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0028 0.0034 0.004
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0042 0.0075 0.0577
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0075 0.0171 0.0199
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0027 0.0032 0.018
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0012 0.0002
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0042 0.0075 0.0577
Plasmodium falciparum telomerase reverse transcriptase 0.0148 0.0379 0.3349
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0042 0.0075 0.0634
Entamoeba histolytica hypothetical protein 0.0042 0.0075 0.0532
Echinococcus multilocularis acylamino acid releasing enzyme 0.0043 0.0079 0.0092
Loa Loa (eye worm) hypothetical protein 0.0042 0.0075 0.0088
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0164 0.0426 0.3716
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0055 0.0033
Brugia malayi Importin beta-1 subunit 0.0032 0.0047 0.0055
Brugia malayi Cathepsin L-like precursor 0.0075 0.0171 0.0199
Loa Loa (eye worm) hypothetical protein 0.0053 0.0106 0.0124
Plasmodium falciparum serine repeat antigen 8 0.0042 0.0075 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Trypanosoma brucei hypothetical protein, conserved 0.0161 0.0418 0.3644
Brugia malayi cathepsin F-like cysteine proteinase 0.0075 0.0171 0.0199
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0027 0.0032 0.018
Leishmania major histone deacetylase, putative 0.0401 0.1109 0.9726
Loa Loa (eye worm) hypothetical protein 0.0075 0.0171 0.0199
Trichomonas vaginalis penicillin-binding protein, putative 0.0161 0.0418 0.0396
Echinococcus granulosus thioredoxin glutathione reductase 0.0109 0.0268 0.0313
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0112 0.0956
Onchocerca volvulus Matrilysin homolog 0.0096 0.0232 0.1535
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0039 0.0068 0.061
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0292 0.034
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0099 0.0076
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.009 0.0212 0.1836
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0055 0.0065
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0106 0.0124
Loa Loa (eye worm) hypothetical protein 0.012 0.0301 0.0351
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0063 0.0525
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0038 0.0063 0.0074
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0027 0.0032 0.0037
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0035 0.0056 0.0065
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0088 0.0102
Entamoeba histolytica cysteine protease, putative 0.0042 0.0075 0.0532
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0042 0.0075 0.0053
Echinococcus granulosus acylamino acid releasing enzyme 0.0043 0.0079 0.0092
Mycobacterium tuberculosis Conserved protein 0.0161 0.0418 0.1433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0393 0.0371
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0412 0.114 0.133
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0126 0.1077
Echinococcus granulosus histone deacetylase 1 0.0367 0.1011 0.118
Brugia malayi Hemopexin family protein 0.0137 0.0348 0.0406
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0126 0.104
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0027 0.0032 0.021
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0099 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0056 0.0457
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0148 0.0379 0.3305
Schistosoma mansoni survival motor neuron protein 0.0054 0.0109 0.0128
Brugia malayi mbt repeat family protein 0.0046 0.0088 0.0102
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.0381 0.0445
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Echinococcus granulosus pyruvate kinase 0.0039 0.0066 0.0077
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0043 0.0079 0.0092
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0038 0.0063 0.0468
Schistosoma mansoni cpg binding protein 0.0033 0.0049 0.0057
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0367 0.1011 0.0991
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0367 0.1011 0.0991
Loa Loa (eye worm) beta-lactamase 0.0161 0.0418 0.0487
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0609 0.593
Onchocerca volvulus 0.0035 0.0056 0.0368
Mycobacterium ulcerans hydrolase 0.0117 0.0292 0.6625
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0075 0.0053
Brugia malayi RNA, U transporter 1 0.0092 0.0218 0.0254
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0609 0.593
Schistosoma mansoni ap endonuclease 0.006 0.0126 0.0147
Schistosoma mansoni histone deacetylase 4 5 0.0401 0.1109 0.1294
Plasmodium falciparum serine repeat antigen 2 0.0042 0.0075 0.0577
Echinococcus multilocularis phospholipase D 0.0028 0.0034 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0609 0.0588
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.003 0.0007
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0031 0.0244
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.009 0.0212 0.1836
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0042 0.0075 0.0088
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0055 0.0065
Giardia lamblia NADH oxidase lateral transfer candidate 0.0038 0.0063 0.0514
Mycobacterium tuberculosis Probable oxidoreductase 0.0277 0.075 0.2574
Trichomonas vaginalis brca1-associated protein, putative 0.0027 0.0032 0.0009
Trypanosoma cruzi histone deacetylase, putative 0.0401 0.1109 0.9726
Echinococcus granulosus MAP kinase activated protein kinase 2 0.2996 0.8571 1
Giardia lamblia Cysteine protease 0.0042 0.0075 0.0634
Schistosoma mansoni ran 0.0024 0.0023 0.0026
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0059 0.0069
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0164 0.0426 0.3716
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0042 0.0075 0.0053
Echinococcus multilocularis histone deacetylase 1 0.0367 0.1011 0.118
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0059 0.0203
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0164 0.0426 0.3716
Schistosoma mansoni ceramide glucosyltransferase 0.0331 0.0907 0.1058
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0151 0.0176
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0032 0.0037
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0409 0.0477
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0043 0.0079 0.0569
Entamoeba histolytica cysteine protease, putative 0.0042 0.0075 0.0532
Schistosoma mansoni hypothetical protein 0.0359 0.0987 0.1151
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0066 0.0552
Brugia malayi Choline O-acetyltransferase 0.0035 0.0056 0.0065
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0043 0.0079 0.0522
Entamoeba histolytica cysteine protease, putative 0.0227 0.0609 0.593
Trichomonas vaginalis histone deacetylase, putative 0.0367 0.1011 0.0991
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0161 0.0418 0.0487
Trypanosoma cruzi major cysteine proteinase, putative 0.0042 0.0075 0.063
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0151 0.0176
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0066 0.0227
Brugia malayi Matrixin family protein 0.0233 0.0625 0.0729
Toxoplasma gondii RNA-directed DNA polymerase 0.0148 0.0379 0.3257
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0023 0.0026
Onchocerca volvulus 0.0227 0.0609 0.4033
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0047 0.0055
Schistosoma mansoni alpha-glucosidase 0.0136 0.0346 0.0403
Schistosoma mansoni hypothetical protein 0.0467 0.1299 0.1515
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0055 0.0455
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0023 0.0167
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0055 0.0331
Echinococcus multilocularis muscleblind protein 1 0.0168 0.0438 0.0511
Echinococcus granulosus histone deacetylase 8 0.0175 0.0456 0.0533
Loa Loa (eye worm) hypothetical protein 0.0161 0.0418 0.0487
Echinococcus multilocularis histone deacetylase 6 0.0428 0.1186 0.1384
Trichomonas vaginalis D-aminoacylase, putative 0.0161 0.0418 0.0396
Echinococcus multilocularis histone deacetylase 0.0401 0.1109 0.1294
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0407 0.0475
Loa Loa (eye worm) hypothetical protein 0.0117 0.0292 0.0341
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0027 0.0032 0.0177
Schistosoma mansoni cathepsin S (C01 family) 0.0042 0.0075 0.0088
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0014 0.0017
Toxoplasma gondii type I fatty acid synthase, putative 0.0042 0.0075 0.0558
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0066 0.0552
Giardia lamblia Encystation-specific protease 0.0042 0.0075 0.0634
Brugia malayi Matrixin family protein 0.0096 0.0232 0.027
Schistosoma mansoni histone deacetylase 4 5 0.0401 0.1109 0.1294
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.1374 0.1603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0075 0.0053
Onchocerca volvulus Matrix metalloproteinase homolog 0.0214 0.0569 0.3771
Loa Loa (eye worm) histone deacetylase 3 0.0367 0.1011 0.118
Brugia malayi cathepsin B-like cysteine proteinase 0.0042 0.0075 0.0088
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0022 0.0019 0.0064
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0027 0.0032 0.0247
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0038 0.0063 0.0525
Trichomonas vaginalis histone deacetylase, putative 0.0367 0.1011 0.0991
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0035 0.0207
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0227 0.0609 0.071
Mycobacterium tuberculosis Probable thioesterase TesA 0.0033 0.0049 0.0167
Plasmodium vivax importin-beta 2, putative 0.0032 0.0047 0.0321
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0025 0.0029
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0164 0.0426 0.3716
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0035 0.0056 0.0457
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0066 0.0484
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0099 0.0773
Echinococcus multilocularis cpg binding protein 0.0037 0.006 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Echinococcus granulosus choline O acetyltransferase 0.0035 0.0056 0.0065
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0027 0.0032 0.0247
Onchocerca volvulus Cathepsin F homolog 0.0227 0.0609 0.4033
Schistosoma mansoni choline o-acyltransferase 0.0035 0.0056 0.0065
Echinococcus granulosus cathepsin L 0.0117 0.0292 0.034
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0025 0.0029
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0028 0.0036 0.0122
Mycobacterium tuberculosis Probable hydrolase 0.0161 0.0418 0.1433
Loa Loa (eye worm) hypothetical protein 0.0367 0.1011 0.118
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0164 0.0426 0.5539
Loa Loa (eye worm) hypothetical protein 0.0042 0.0075 0.0088
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0047 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0042 0.0075 0.0053
Giardia lamblia Cathepsin B precursor 0.0042 0.0075 0.0634
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.009 0.0212 0.1836
Echinococcus granulosus cathepsin l1 0.0152 0.0393 0.0458
Plasmodium falciparum thioredoxin reductase 0.0109 0.0268 0.2338
Trypanosoma cruzi cysteine protease, putative 0.0117 0.0292 0.2533
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0055 0.0455
Loa Loa (eye worm) choline O-acetyltransferase 0.0035 0.0056 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0227 0.0609 0.0588
Toxoplasma gondii thioredoxin reductase 0.0109 0.0268 0.2274
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.1374 0.1603
Schistosoma mansoni hypothetical protein 0.0293 0.0798 0.0931
Brugia malayi Bromodomain containing protein 0.009 0.0212 0.0247
Onchocerca volvulus 0.0227 0.0609 0.4033
Schistosoma mansoni hypothetical protein 0.0137 0.0348 0.0406
Echinococcus multilocularis cysteine protease 0.0227 0.0609 0.071
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0055 0.0033
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0042 0.0075 0.0577
Loa Loa (eye worm) hypothetical protein 0.0066 0.0145 0.0169
Schistosoma mansoni pyruvate kinase 0.0039 0.0066 0.0077
Brugia malayi map kinase activated protein kinase protein 2 0.2996 0.8571 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.008 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0079 0.0056
Onchocerca volvulus Cathepsin L homolog 0.0227 0.0609 0.4033
Plasmodium vivax vivapain-2 0.0227 0.0609 0.5441
Mycobacterium tuberculosis Probable reductase 0.0249 0.067 0.23
Giardia lamblia Cathepsin B precursor 0.0042 0.0075 0.0634
Onchocerca volvulus Prolyl endopeptidase homolog 0.0412 0.114 0.7553
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.008 0.058
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0027 0.0031 0.0088
Entamoeba histolytica cysteine protease, putative 0.0117 0.0292 0.2721
Echinococcus granulosus cysteine protease 0.0117 0.0292 0.034
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0066 0.0439
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.003 0.0007
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0042 0.0075 0.0088
Onchocerca volvulus Histone deacetylase 10 homolog 0.0175 0.0456 0.3023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0096 0.0112
Trypanosoma cruzi major cysteine proteinase, putative 0.0152 0.0391 0.3406
Leishmania major histone deacetylase, putative 0.0367 0.1011 0.8864
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0038 0.0063 0.337
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0227 0.0609 0.071
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0367 0.1011 0.0991
Loa Loa (eye worm) hypothetical protein 0.0161 0.0418 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0609 0.0588
Giardia lamblia Ceramide glucosyltransferase 0.015 0.0386 0.3748
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0051 0.006
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0088 0.0102
Plasmodium vivax histone deacetylase, putative 0.0175 0.0456 0.4052
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0038 0.0063 0.337
Trichomonas vaginalis histone deacetylase, putative 0.0367 0.1011 0.0991
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0033 0.0049 0.035
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0039 0.0068 0.0079
Brugia malayi Phospholipase d protein 1 0.0031 0.0045 0.0053
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0027 0.0032 0.0247
Echinococcus granulosus pyruvate kinase 0.002 0.0012 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0042 0.0075 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0161 0.0418 0.9792
Onchocerca volvulus 0.0091 0.0217 0.1439
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0171 0.1471
Onchocerca volvulus 0.0037 0.006 0.0399
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0026 0.0031 0.008
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0042 0.0075 0.0088
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0042 0.0075 0.0577
Toxoplasma gondii NADPH-glutathione reductase 0.0038 0.0063 0.0457
Brugia malayi Choline O-acetyltransferase 0.0035 0.0056 0.0065
Trichomonas vaginalis importin beta-1, putative 0.0026 0.003 0.0007
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0096 0.0232 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0161 0.0418 0.3644

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -6 % Renal vasodilator activity in anesthetized dogs and percent change in heart rate (HR) was determined at 3 microg/kg min ChEMBL. 6699878
Change (functional) = -5 % Renal vasodilator activity in anesthetized dogs and percent change in renal vascular resistance (RVR) was determined at 3 microg/kg min ChEMBL. 6699878
Change (functional) = -4 % Renal vasodilator activity in anesthetized dogs and percent change in mean arterial blood pressure (MABP) was determined at 300 microg/kg min ChEMBL. 6699878
Change (functional) = -3 % Renal vasodilator activity in anesthetized dogs and percent change in renal blood flow (RBF) was determined at 300 microg/kg min ChEMBL. 6699878
Change (functional) = -2 % Renal vasodilator activity in anesthetized dogs and percent change in renal vascular resistance (RVR) was determined at at 30 microg/kg min ChEMBL. 6699878
Change (functional) = -1 % Renal vasodilator activity in anesthetized dogs and percent change in mean arterial blood pressure (MABP) was determined at 3 microg/kg min ChEMBL. 6699878
Change (functional) = 0 % Renal vasodilator activity in anesthetized dogs and percent change in renal vascular resistance (RVR) was determined at 300 microg/kg min ChEMBL. 6699878
Change (functional) = 1 % Renal vasodilator activity in anesthetized dogs and percent change in mean arterial blood pressure (MABP) was determined at 30 microg/kg min ChEMBL. 6699878
Change (functional) = 3 % Renal vasodilator activity in anesthetized dogs and percent change in renal blood flow (RBF) was determined at 30 microg/kg min ChEMBL. 6699878
Change (functional) = 3 % Renal vasodilator activity in anesthetized dogs and percent change in heart rate (HR) was determined at 30 microg/kg min ChEMBL. 6699878
Change (functional) = 4 % Renal vasodilator activity in anesthetized dogs and percent change in renal blood flow (RBF) was determined at 3 microg/kg min ChEMBL. 6699878
Change (functional) = 6 % Renal vasodilator activity in anesthetized dogs and percent change in heart rate (HR) was determined at 300 microg/kg min ChEMBL. 6699878

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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