Detailed information for compound 406857

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1538.66 | Formula: C77H91N19O16
  • H donors: 20 H acceptors: 17 LogP: -2.25 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 4
  • SMILES: Oc1ccc(cc1)C[C@H](N1C(=O)C[C@@H](NC(=O)[C@H](Cc2ccc(cc2)O)N)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2cccc3c2cccc3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NC1(C)C(=O)O)Cc1ccccc1)C)CC(=O)N)Cc1c[nH]c2c1cccc2)C(O)N
  • InChi: 1S/C77H91N19O16/c1-41-66(102)89-56(31-42-12-4-3-5-13-42)74(110)95-77(2,75(111)112)96(62(65(80)101)32-44-23-27-50(98)28-24-44)64(100)37-61(90-67(103)53(78)30-43-21-25-49(97)26-22-43)73(109)93-59(35-48-39-83-40-86-48)72(108)92-57(33-46-16-10-15-45-14-6-7-17-51(45)46)70(106)88-55(20-11-29-84-76(81)82)68(104)91-58(34-47-38-85-54-19-9-8-18-52(47)54)71(107)94-60(36-63(79)99)69(105)87-41/h3-10,12-19,21-28,38-41,53,55-62,65,85,97-98,101H,11,20,29-37,78,80H2,1-2H3,(H2,79,99)(H,83,86)(H,87,105)(H,88,106)(H,89,102)(H,90,103)(H,91,104)(H,92,108)(H,93,109)(H,94,107)(H,95,110)(H,111,112)(H4,81,82,84)/t41-,53+,55+,56+,57+,58-,59+,60+,61+,62+,65?,77?/m1/s1
  • InChiKey: NNBYUTYDWRBNJK-BGOIQEOQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH1 domain containing protein 0.0041 0.0025 0.0198
Onchocerca volvulus 0.0048 0.0033 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0061
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0011 0.0084
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.003 0.0178
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0003 0.0022
Brugia malayi beta-lactamase family protein 0.0073 0.0059 0.0464
Onchocerca volvulus 0.0223 0.0213 0.2691
Echinococcus multilocularis epidermal growth factor receptor 0.1234 0.1248 0.7532
Echinococcus granulosus chromobox protein 1 0.0068 0.0053 0.0377
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0016 0.0122
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0041 0.0026 0.0199
Echinococcus granulosus cathepsin l1 0.0041 0.0026 0.0178
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0002 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.0144 0.1031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0127 0.0762
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Loa Loa (eye worm) hypothetical protein 0.0105 0.0091 0.0725
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0049 0.0353
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.008
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0009 0.0063
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0176 0.0164 0.1175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0155
Onchocerca volvulus 0.0073 0.0059 0.0725
Loa Loa (eye worm) hypothetical protein 0.0089 0.0075 0.0599
Loa Loa (eye worm) beta-lactamase 0.0073 0.0059 0.0464
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0006 0.0036
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.003 0.0178
Loa Loa (eye worm) RNA binding protein 0.0064 0.0049 0.039
Loa Loa (eye worm) hypothetical protein 0.0354 0.0347 0.2774
Onchocerca volvulus 0.0176 0.0164 0.2075
Brugia malayi tailless protein 0.0021 0.0006 0.004
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0006 0.004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0008 0.0046
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.002 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0317 0.0309 0.2472
Mycobacterium ulcerans dehydrogenase 0.0733 0.0735 0.0733
Schistosoma mansoni zinc finger protein 0.0023 0.0008 0.0056
Brugia malayi Smad1 0.0041 0.0025 0.0198
Loa Loa (eye worm) hypothetical protein 0.0733 0.0735 0.5888
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0009 0.0006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0033 0.0257
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0026 0.0305
Loa Loa (eye worm) hypothetical protein 0.0176 0.0164 0.1312
Echinococcus multilocularis transmembrane protease serine 3 0.0176 0.0164 0.0988
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0071 0.0427
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0026 0.0199
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0059 0.0349
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0013 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0213
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0663 0.0663 0.4736
Leishmania major cathepsin L-like protease 0.0041 0.0026 0.0348
Mycobacterium ulcerans monoamine oxidase 0.0733 0.0735 0.0733
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0202 0.0191 0.1365
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Brugia malayi Calcium binding EGF domain containing protein 0.0223 0.0213 0.17
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0002 0.0002
Mycobacterium leprae Probable lipase LipE 0.0073 0.0059 0.0705
Brugia malayi MH2 domain containing protein 0.0018 0.0002 0.0014
Giardia lamblia Cathepsin B precursor 0.006 0.0046 0.2089
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0164 0.1175
Loa Loa (eye worm) hypothetical protein 0.0089 0.0075 0.0599
Mycobacterium tuberculosis Conserved protein 0.0073 0.0059 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Echinococcus granulosus glycoprotein Antigen 5 0.0176 0.0164 0.117
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0009 0.0368
Loa Loa (eye worm) hypothetical protein 0.0078 0.0064 0.0509
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0003 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Brugia malayi Trypsin family protein 0.0176 0.0164 0.1312
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.0075 0.0599
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0002 0.0008
Loa Loa (eye worm) DR-78 0.0021 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0026 0.0519
Brugia malayi cathepsin F-like cysteine proteinase 0.0023 0.0008 0.0057
Echinococcus granulosus delta-like protein 1 0.0223 0.0213 0.1516
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0733 0.0735 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0013 0.0088
Loa Loa (eye worm) transcription factor SMAD2 0.0595 0.0593 0.4752
Chlamydia trachomatis protoporphyrinogen oxidase 0.0733 0.0735 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Brugia malayi TAR-binding protein 0.0064 0.0049 0.039
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0007 0.0068
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0176 0.0164 0.117
Leishmania major cathepsin L-like protease 0.0041 0.0026 0.0348
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0074
Onchocerca volvulus 0.0089 0.0075 0.0941
Loa Loa (eye worm) hypothetical protein 0.0317 0.0309 0.2472
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0059 0.0056
Onchocerca volvulus 0.0317 0.0309 0.3919
Onchocerca volvulus 0.0783 0.0786 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0002 0.0002
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.0175 0.221
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0175 0.3705
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.003 0.0216
Echinococcus multilocularis kinesin family 1 0.0642 0.0641 0.3869
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0325 0.0317 0.4298
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0053 0.0423
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0041 0.0026 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0175 0.3705
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0003 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0059 0.1218
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0016 0.0122
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0187 0.0175 0.1053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.0002
Loa Loa (eye worm) cysteine protease 0.0041 0.0026 0.0199
Echinococcus multilocularis GPCR, family 2 0.0112 0.0099 0.0592
Onchocerca volvulus 0.0041 0.0026 0.0305
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0017 0.0002 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0016 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Brugia malayi nuclear receptor NHR-67 0.0021 0.0006 0.004
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0009 0.0063
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.0223 0.1345
Brugia malayi Bromodomain containing protein 0.0031 0.0016 0.0119
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0097
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0155
Echinococcus multilocularis neurogenic locus notch protein 0.0223 0.0213 0.128
Loa Loa (eye worm) hypothetical protein 0.0073 0.0058 0.0462
Onchocerca volvulus 0.0073 0.0059 0.0725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Echinococcus granulosus kinesin family 1 0.0642 0.0641 0.458
Brugia malayi Calcitonin receptor-like protein seb-1 0.0354 0.0347 0.2774
Echinococcus granulosus lysine specific histone demethylase 1A 0.0733 0.0735 0.525
Loa Loa (eye worm) hypothetical protein 0.0112 0.0099 0.0786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0044 0.0347
Loa Loa (eye worm) PAN domain-containing protein 0.0317 0.0309 0.2472
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Brugia malayi cathepsin L precursor 0.0017 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0099
Brugia malayi Cathepsin L-like precursor 0.0041 0.0026 0.0199
Giardia lamblia PHD finger protein 15 0.0028 0.0013 0.0538
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0002 0.0012
Echinococcus granulosus dnaJ subfamily B 0.0829 0.0832 0.5948
Echinococcus multilocularis notch 0.0223 0.0213 0.128
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.001 0.0075
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0059 0.0705
Toxoplasma gondii EGF family domain-containing protein 0.0223 0.0213 0.0419
Brugia malayi PXA domain containing protein 0.0019 0.0003 0.0019
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0079 0.0562
Echinococcus multilocularis 0.0382 0.0375 0.2261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.0002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0026 0.0309
Leishmania major cysteine peptidase A (CPA) 0.0041 0.0026 0.0348
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0059 0.0062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0016 0.0114
Brugia malayi beta-lactamase 0.0073 0.0059 0.0464
Schistosoma mansoni hypothetical protein 0.0223 0.0213 0.152
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0011 0.0079
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0006 0.003
Onchocerca volvulus 0.0176 0.0164 0.2075
Schistosoma mansoni lamin 0.0027 0.0011 0.008
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0013 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0004 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0026 0.1284
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.0099 0.0786
Echinococcus granulosus epidermal growth factor receptor 0.1234 0.1248 0.8917
Leishmania major cathepsin L-like protease 0.0041 0.0026 0.0348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0002 0.0002
Schistosoma mansoni jumonji domain containing protein 0.0074 0.006 0.0426
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Echinococcus multilocularis slit 2 protein 0.0223 0.0213 0.128
Echinococcus multilocularis cathepsin L 0.0017 0.0002 0.0006
Plasmodium falciparum cysteine proteinase falcipain 3 0.0041 0.0026 0.0326
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Schistosoma mansoni cpg binding protein 0.0063 0.0049 0.0349
Onchocerca volvulus 0.0176 0.0164 0.2075
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0733 0.0735 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0002 0.0013
Schistosoma mansoni cpg binding protein 0.0063 0.0049 0.0349
Schistosoma mansoni thyroid hormone receptor 0.0045 0.003 0.0216
Loa Loa (eye worm) hypothetical protein 0.0073 0.0059 0.0464
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0008 0.0061
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0016 0.0092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.003 0.0216
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0059 0.0464
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.003 0.0211
Echinococcus multilocularis cysteine protease 0.0041 0.0026 0.015
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.0223 0.1592
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.003 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0005 0.0023
Brugia malayi hypothetical protein 0.0024 0.0008 0.0061
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0019 0.0111
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0027 0.1371
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0017 0.0002 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0025 0.0175
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.003 0.0178
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0025 0.0198
Loa Loa (eye worm) hypothetical protein 0.0733 0.0735 0.5888
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0164 0.1175
Loa Loa (eye worm) hypothetical protein 0.0733 0.0735 0.5888
Plasmodium vivax unspecified product 0.0041 0.0026 0.0326
Brugia malayi nuclear receptor NHR-88 0.0045 0.003 0.0236
Schistosoma mansoni hypothetical protein 0.067 0.067 0.479
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0049
Loa Loa (eye worm) histone methyltransferase 0.002 0.0005 0.0031
Brugia malayi Protein kinase domain containing protein 0.0394 0.0388 0.3104
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0733 0.0735 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0001 0.0002
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0325 0.0317 0.0315
Schistosoma mansoni hypothetical protein 0.0082 0.0068 0.0488
Echinococcus multilocularis protein dispatched 1 0.0098 0.0084 0.0502
Mycobacterium tuberculosis Conserved protein 0.0073 0.0059 0.0062
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.0006 0.0041
Onchocerca volvulus 0.0021 0.0006 0.0052
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0002 0.0013
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.0046 0.2615
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Loa Loa (eye worm) nuclear factor I 0.0022 0.0007 0.0049
Brugia malayi MH1 domain containing protein 0.0022 0.0007 0.0049
Brugia malayi EGF-like domain containing protein 0.0223 0.0213 0.17
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0067 0.0531
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0049 0.039
Loa Loa (eye worm) PAN domain-containing protein 0.0317 0.0309 0.2472
Onchocerca volvulus 0.0041 0.0026 0.0305
Onchocerca volvulus 0.0223 0.0213 0.2691
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0008 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0127 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0032
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0027 0.1371
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.002 0.0137
Leishmania major cathepsin L-like protease 0.0041 0.0026 0.0348
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0236
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0008 0.006
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0007 0.5
Loa Loa (eye worm) hypothetical protein 0.0085 0.0071 0.0567
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.003 0.0211
Onchocerca volvulus 0.0089 0.0075 0.0941
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0059 0.0062
Toxoplasma gondii microneme protein MIC4 0.0317 0.0309 0.0611
Brugia malayi intermediate filament protein 0.0027 0.0011 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0026 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0032
Echinococcus granulosus microtubule associated protein 2 0.1382 0.1399 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0059 0.0062
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0236
Echinococcus granulosus FTZ F1 alpha 0.0045 0.003 0.0211
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0045 0.0043
Giardia lamblia High cysteine protein 0.0223 0.0213 1
Loa Loa (eye worm) trypsin family protein 0.0176 0.0164 0.1312
Loa Loa (eye worm) hypothetical protein 0.0073 0.0059 0.0464
Entamoeba histolytica cysteine proteinase 1, putative 0.0041 0.0026 0.1284
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0027 0.1371
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0116
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0002 0.0012
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.0006 0.0041
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0016 0.0195
Onchocerca volvulus Putative cubilin 0.0223 0.0213 0.2691
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.003 0.0216
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.0046 0.0623
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0013 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0155
Loa Loa (eye worm) hypothetical protein 0.0242 0.0232 0.1854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Trypanosoma cruzi cruzipain precursor, putative 0.0041 0.0026 0.0348
Toxoplasma gondii histone lysine-specific demethylase 0.0733 0.0735 0.1457
Echinococcus granulosus zinc finger protein 0.0023 0.0008 0.0051
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.0046 0.0623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0127 0.0906
Schistosoma mansoni hypothetical protein 0.0082 0.0068 0.0488
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.003 0.0216
Schistosoma mansoni hypothetical protein 0.0035 0.002 0.0142
Schistosoma mansoni hypothetical protein 0.0112 0.0099 0.0705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Toxoplasma gondii PAN/Apple domain-containing protein 0.0317 0.0309 0.0611
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.003 0.0363
Echinococcus multilocularis protein jagged 2 0.0223 0.0213 0.128
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0176 0.0164 0.0988
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0016 0.0016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0045 0.0267
Schistosoma mansoni nuclear receptor 0.0021 0.0006 0.0041
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0223 0.0213 0.17
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Schistosoma mansoni tyrosine kinase 0.0394 0.0388 0.2771
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0013
Echinococcus multilocularis glycoprotein Antigen 5 0.0176 0.0164 0.0988
Toxoplasma gondii kinesin motor domain-containing protein 0.0083 0.0069 0.0134
Echinococcus multilocularis zinc finger protein 0.0023 0.0008 0.0043
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0011 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Echinococcus granulosus intermediate filament protein 0.0027 0.0011 0.0075
Echinococcus granulosus neurogenic locus notch protein 0.0223 0.0213 0.1516
Toxoplasma gondii microneme protein, putative 0.0317 0.0309 0.0611
Brugia malayi latrophilin 2 splice variant baaae 0.0242 0.0232 0.1854
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0025 0.0182
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0013 0.0073
Brugia malayi ecdysteroid receptor 0.0045 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0057
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0017 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0456
Echinococcus granulosus cysteine protease 0.0041 0.0026 0.0178
Echinococcus multilocularis cathepsin L cysteine protease 0.0041 0.0026 0.015
Schistosoma mansoni bromodomain containing protein 0.0068 0.0054 0.0385
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.0002 0.0008
Loa Loa (eye worm) Notch2 0.0223 0.0213 0.17
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.003 0.0216
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0043 0.03
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0733 0.0735 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0021
Schistosoma mansoni hypothetical protein 0.0048 0.0033 0.0234
Loa Loa (eye worm) TK/INSR protein kinase 0.0394 0.0388 0.3104
Loa Loa (eye worm) hypothetical protein 0.0317 0.0309 0.2472
Schistosoma mansoni hypothetical protein 0.0112 0.0099 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0019
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Echinococcus multilocularis cysteine protease 0.0041 0.0026 0.015
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Schistosoma mansoni hypothetical protein 0.0082 0.0068 0.0488
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Schistosoma mansoni cathepsin s 0.0023 0.0008 0.0056
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0023 0.0008 0.0057
Schistosoma mansoni cathepsin S (C01 family) 0.0017 0.0002 0.0012
Echinococcus multilocularis neural cadherin 0.0223 0.0213 0.128
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0006 0.0052
Brugia malayi Trypsin-like protease protein 5 0.0176 0.0164 0.1312
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.9048 0.9249 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0002 0.0008
Brugia malayi Calcium binding EGF domain containing protein 0.0223 0.0213 0.17
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0236
Onchocerca volvulus 0.0317 0.0309 0.3919
Echinococcus multilocularis chromobox protein 1 0.0068 0.0053 0.0319
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.003 0.0236
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0006 0.0041
Schistosoma mansoni septate junction protein 0.0223 0.0213 0.152
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0003 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.003 0.0236
Schistosoma mansoni slit 0.0223 0.0213 0.152
Schistosoma mansoni hypothetical protein 0.0223 0.0213 0.152
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0059 0.0414
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0016 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0209
Onchocerca volvulus 0.0317 0.0309 0.3919
Loa Loa (eye worm) hypothetical protein 0.0176 0.0164 0.1312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0016 0.0092
Brugia malayi Cathepsin L-like precursor 0.0041 0.0026 0.0199
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0045 0.0611
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0041 0.0026 0.0326
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0074
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0394 0.0388 0.2338
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0006 0.004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.0144 0.1031
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0164 0.1175
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0013 0.0155
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0024 0.0143
Schistosoma mansoni nuclear receptor 0.0021 0.0006 0.0041
Leishmania major cathepsin L-like protease 0.0041 0.0026 0.0348
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.003 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0064 0.0459
Echinococcus granulosus peregrin 0.0031 0.0016 0.0106
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0002 0.0012
Plasmodium vivax vivapain-2 0.0041 0.0026 0.0326
Plasmodium falciparum kinesin-5 0.0083 0.0069 0.0922
Loa Loa (eye worm) PAN domain-containing protein 0.0317 0.0309 0.2472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Schistosoma mansoni microtubule-associated protein tau 0.1382 0.1399 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0004 0.0024
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.0275 0.1964
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0006 0.0036
Schistosoma mansoni hypothetical protein 0.0223 0.0213 0.152
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0026 0.1284
Loa Loa (eye worm) PAN domain-containing protein 0.0317 0.0309 0.2472
Entamoeba histolytica kinesin, putative 0.0083 0.0069 0.3632
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Schistosoma mansoni kinesin eg-5 0.0083 0.0069 0.0495
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0041 0.0026 0.0326
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0006 0.003
Brugia malayi hypothetical protein 0.0035 0.002 0.0153
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0236
Trypanosoma cruzi cysteine proteinase, putative 0.0041 0.0026 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.003 0.0236
Schistosoma mansoni tyrosine kinase 0.0656 0.0656 0.4687
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0176 0.0164 0.1312
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.0099 0.0701
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0025 0.0149
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0023 0.0271
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0016 0.0092
Plasmodium vivax SET domain protein, putative 0.0061 0.0046 0.0608
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0002 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.003 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.003 0.0178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Schistosoma mansoni smad1 5 8 and 0.0041 0.0025 0.0182
Brugia malayi steroid hormone receptor 0.0045 0.003 0.0236
Schistosoma mansoni zinc finger protein 0.0021 0.0006 0.0041
Echinococcus granulosus enteropeptidase 0.0176 0.0164 0.117
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0223 0.0213 0.152
Schistosoma mansoni chromobox protein 0.0068 0.0053 0.0382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Schistosoma mansoni survival motor neuron protein 0.0048 0.0033 0.0234
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0733 0.0735 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0005 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0009 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.003 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Onchocerca volvulus 0.0027 0.0011 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0127 0.0902
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.003 0.0236
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.0275 0.1659
Echinococcus granulosus expressed protein 0.0364 0.0357 0.2545
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Entamoeba histolytica hypothetical protein 0.0019 0.0003 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0049 0.0353
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0008 0.0106
Schistosoma mansoni smad 0.0041 0.0025 0.0182
Loa Loa (eye worm) hypothetical protein 0.0733 0.0735 0.5888
Echinococcus multilocularis Smad4 0.0041 0.0025 0.0149
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0733 0.0735 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0007 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0008 0.0106
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Brugia malayi Bromodomain containing protein 0.008 0.0066 0.0525
Brugia malayi N-terminal motif family protein 0.0192 0.0181 0.1445
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0002 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0456
Echinococcus granulosus notch 0.0223 0.0213 0.1516
Schistosoma mansoni amine oxidase 0.0733 0.0735 0.5253
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0064 0.0383
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0007 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0009 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0002 0.0008
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.0002 0.0023
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0002 0.0008
Schistosoma mansoni tyrosine kinase 0.1234 0.1248 0.8918
Entamoeba histolytica cysteine proteinase 2 0.0041 0.0026 0.1284
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0041 0.0026 0.015
Schistosoma mansoni tyrosine kinase 0.0656 0.0656 0.4687
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0164 0.1175
Loa Loa (eye worm) MH2 domain-containing protein 0.0595 0.0593 0.4752
Plasmodium vivax unspecified product 0.0023 0.0008 0.0084
Schistosoma mansoni notch 0.0223 0.0213 0.152
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0049 0.0353
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Schistosoma mansoni cathepsin B (C01 family) 0.0017 0.0002 0.0012
Toxoplasma gondii cathepsin CPL 0.0041 0.0026 0.0048
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0026 0.0348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Schistosoma mansoni tyrosine kinase 0.0656 0.0656 0.4687
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.005 0.0298
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.003 0.0216
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0059 0.0056
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0016 0.0109
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0007 0.0076
Onchocerca volvulus 0.0317 0.0309 0.3919
Brugia malayi SWIRM domain containing protein 0.0733 0.0735 0.5888
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0002 0.0014
Schistosoma mansoni notch 0.0223 0.0213 0.152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Loa Loa (eye worm) hypothetical protein 0.0073 0.0059 0.0464
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0045 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0002 0.0002
Echinococcus granulosus Smad4 0.0041 0.0025 0.0177
Brugia malayi GCC2 and GCC3 family protein 0.0223 0.0213 0.17
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.003 0.0236
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0003 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.003 0.0178
Onchocerca volvulus 0.0223 0.0213 0.2691
Schistosoma mansoni lamin 0.0027 0.0011 0.008
Schistosoma mansoni smad1 5 8 and 0.0041 0.0025 0.0182
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0059 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0078 0.1644
Echinococcus multilocularis expressed protein 0.0364 0.0357 0.2149
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0102 0.0198
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0075 0.0599
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0155
Mycobacterium ulcerans beta-lactamase 0.0073 0.0059 0.0056
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Brugia malayi Calcium binding EGF domain containing protein 0.0223 0.0213 0.17
Onchocerca volvulus 0.0041 0.0026 0.0305
Schistosoma mansoni notch 0.0223 0.0213 0.152
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.003 0.0216
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0009 0.0063
Loa Loa (eye worm) Smad1 0.0041 0.0025 0.0198
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0164 0.1175
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0394 0.0388 0.2768
Loa Loa (eye worm) hypothetical protein 0.0317 0.0309 0.2472
Loa Loa (eye worm) hypothetical protein 0.0176 0.0164 0.1312
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.003 0.0178
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Echinococcus multilocularis fat cadherin tumor suppressor 0.0223 0.0213 0.128
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.003 0.0236
Toxoplasma gondii subtilisin SUB12 0.0317 0.0309 0.0611
Toxoplasma gondii PAN domain-containing protein 0.0317 0.0309 0.0611
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0009 0.0155
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0187 0.0175 0.2381
Loa Loa (eye worm) hypothetical protein 0.0733 0.0735 0.5888
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0006 0.004
Onchocerca volvulus 0.0474 0.047 0.5967
Brugia malayi hypothetical protein 0.0021 0.0006 0.004
Brugia malayi EGF-like domain containing protein 0.0223 0.0213 0.17
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0317 0.0309 0.0611
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0157 0.0144 0.1963
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0155
Leishmania major cathepsin L-like protease 0.0041 0.0026 0.0348
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Schistosoma mansoni intermediate filament proteins 0.0027 0.0011 0.008
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0006 0.0036
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0006 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.003 0.0211
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0187 0.0175 0.1246
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0003 0.0019
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0026 0.0305
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0006 0.003
Echinococcus multilocularis protein patched 0.0085 0.0071 0.0427
Loa Loa (eye worm) hypothetical protein 0.0073 0.0059 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0003 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0041 0.0026 0.0513
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0189
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.003 0.0236
Brugia malayi serine/threonine-protein kinase plk-2 0.0187 0.0175 0.1397
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0016 0.0912
Brugia malayi Delta serrate ligand family protein 0.0223 0.0213 0.17
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0175 0.125
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0003 0.0014
Echinococcus multilocularis chromobox protein 1 0.0068 0.0053 0.0319
Echinococcus multilocularis geminin 0.067 0.067 0.4043
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0006 0.003
Echinococcus granulosus jumonji domain containing protein 0.004 0.0024 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Brugia malayi Cathepsin L-like precursor 0.0017 0.0002 0.0008
Brugia malayi RNA binding protein 0.0064 0.0049 0.039
Toxoplasma gondii PAN domain-containing protein 0.0317 0.0309 0.0611
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0733 0.0735 0.4434
Echinococcus multilocularis cpg binding protein 0.0063 0.0049 0.0291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.003 0.0211
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.003 0.0236
Brugia malayi nuclear hormone receptor 0.0045 0.003 0.0236
Echinococcus granulosus chromobox protein 1 0.0068 0.0053 0.0377
Echinococcus granulosus epidermal growth factor receptor 0.0663 0.0663 0.4736
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.0002
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0157 0.0144 0.1031
Brugia malayi Pre-SET motif family protein 0.0061 0.0046 0.0365
Brugia malayi PXA domain containing protein 0.0019 0.0003 0.0019
Brugia malayi Cathepsin L-like precursor 0.0041 0.0026 0.0199
Schistosoma mansoni tyrosinase precursor 0.0089 0.0075 0.0539
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0178
Toxoplasma gondii microneme protein MIC17B 0.0317 0.0309 0.0611
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0006 0.004
Brugia malayi Kinesin motor domain containing protein 0.0083 0.0069 0.055
Trypanosoma brucei polo-like protein kinase 0.0187 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0013
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0002 0.0007
Echinococcus granulosus tar DNA binding protein 0.0064 0.0049 0.0348
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0027 0.1371
Echinococcus granulosus cathepsin b 0.0157 0.0144 0.1026
Entamoeba histolytica hypothetical protein 0.0035 0.002 0.0975
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0026
Entamoeba histolytica serine/threonine protein kinase, putative 0.0187 0.0175 0.9307
Brugia malayi Cathepsin L-like precursor 0.0041 0.0026 0.0199
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0192 0.0181 0.1445
Entamoeba histolytica hypothetical protein 0.0035 0.002 0.0975
Echinococcus granulosus insulin receptor 0.0394 0.0388 0.2768
Brugia malayi PHD-finger family protein 0.0028 0.0013 0.0099
Schistosoma mansoni cell polarity protein 0.0223 0.0213 0.152
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.0188 0.1338
Loa Loa (eye worm) hypothetical protein 0.0199 0.0188 0.1501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Brugia malayi hypothetical protein 0.0733 0.0735 0.5888
Plasmodium vivax kinesin-5 0.0083 0.0069 0.0922
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0049 0.0353
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0013
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0013 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0059 0.0797
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0059 0.0776
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0017 0.0002 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0017 0.0002 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0059 0.0797
Echinococcus multilocularis fibropellin Ia 0.0223 0.0213 0.128
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0009 0.0006
Onchocerca volvulus Alhambra homolog 0.0028 0.0013 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Trichomonas vaginalis set domain proteins, putative 0.0474 0.047 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0026 0.0519
Loa Loa (eye worm) hypothetical protein 0.0041 0.0026 0.0199
Schistosoma mansoni hypothetical protein 0.0028 0.0013 0.0093
Brugia malayi Cathepsin L-like precursor 0.0041 0.0026 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0059 0.1218
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0026 0.0199
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0002 0.0008
Giardia lamblia Cathepsin B precursor 0.006 0.0046 0.2089
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0733 0.0735 0.5253
Brugia malayi Cathepsin L-like precursor 0.0017 0.0002 0.0008
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0026 0.0348
Brugia malayi Cathepsin L-like precursor 0.0023 0.0008 0.0057
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0018 0.0002 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.0099 0.0786
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.003 0.0211
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0325 0.0317 0.4303
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0317 0.0309 0.2472
Loa Loa (eye worm) TK/EGFR protein kinase 0.1234 0.1248 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0011 0.0084
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.003 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0017 0.0002 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0064 0.0454
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0013 0.0086
Schistosoma mansoni smad1 5 8 and 0.0041 0.0025 0.0182
Loa Loa (eye worm) PAN domain-containing protein 0.0317 0.0309 0.2472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0059 0.1218
Brugia malayi fibroinase precursor 0.0017 0.0002 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0057
Loa Loa (eye worm) ctsf protein 0.0041 0.0026 0.0199
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0187 0.0175 0.1397
Echinococcus multilocularis cathepsin L 0.0041 0.0026 0.015
Echinococcus multilocularis microtubule associated protein 2 0.1382 0.1399 0.8446
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0127 0.0902
Echinococcus multilocularis enteropeptidase 0.0176 0.0164 0.0988
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0075 0.0599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0053 0.1109
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Onchocerca volvulus 0.0058 0.0043 0.0533
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0026 0.1284
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0008 0.0055
Schistosoma mansoni smad 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0157 0.0144 0.1151
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.003 0.0178
Schistosoma mansoni hypothetical protein 0.0223 0.0213 0.152
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0236
Loa Loa (eye worm) fibroinase 0.0041 0.0026 0.0199
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0009 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.0099 0.0701
Onchocerca volvulus 0.0317 0.0309 0.3919
Onchocerca volvulus 0.0027 0.0011 0.0122
Schistosoma mansoni Smad4 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0019
Echinococcus granulosus cathepsin l cysteine peptidase 0.0041 0.0026 0.0178
Trypanosoma cruzi cysteine proteinase, putative 0.0041 0.0026 0.0348
Echinococcus granulosus lamin dm0 0.0027 0.0011 0.0075
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0007 0.0414
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0325 0.0317 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0733 0.0735 0.5888
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0016 0.0217
Schistosoma mansoni hypothetical protein 0.0242 0.0232 0.1657
Brugia malayi EGF-like domain containing protein 0.0223 0.0213 0.17
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0025 0.0177
Echinococcus granulosus cpg binding protein 0.0063 0.0049 0.0345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0127 0.1011
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0026 0.0183
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0053 0.1109
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0002 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0112 0.0099 0.0786
Brugia malayi jmjC domain containing protein 0.0093 0.0079 0.063
Loa Loa (eye worm) hypothetical protein 0.0176 0.0164 0.1312
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0026 0.0348
Schistosoma mansoni hypothetical protein 0.0559 0.0556 0.3973
Echinococcus granulosus cathepsin L 0.0041 0.0026 0.0178
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0008 0.0061
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0223 0.0213 0.2691
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Brugia malayi EGF-like domain containing protein 0.0223 0.0213 0.17
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0155
Schistosoma mansoni cathepsin C 0.0017 0.0002 0.0012
Schistosoma mansoni hypothetical protein 0.0176 0.0164 0.1175
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.0461 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.003 0.0236
Mycobacterium ulcerans hypothetical protein 0.0024 0.0009 0.0006
Toxoplasma gondii PAN domain-containing protein 0.4933 0.5035 1
Schistosoma mansoni hypothetical protein 0.0112 0.0099 0.0705
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.003 0.0236
Brugia malayi Pre-SET motif family protein 0.0417 0.0411 0.3289
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0025 0.0191
Brugia malayi Bromodomain containing protein 0.0039 0.0024 0.0188
Echinococcus multilocularis protoporphyrinogen oxidase 0.0733 0.0735 0.4434
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0045 0.0321
Schistosoma mansoni tyrosine kinase 0.0663 0.0663 0.4738
Schistosoma mansoni patched 1 0.0085 0.0071 0.0511
Brugia malayi MH2 domain containing protein 0.0041 0.0025 0.0198
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Toxoplasma gondii PAN domain-containing protein 0.0317 0.0309 0.0611
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.0175 0.2381
Echinococcus multilocularis neurogenic locus protein delta 0.0223 0.0213 0.128
Brugia malayi Cathepsin L-like precursor 0.0041 0.0026 0.0199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Schistosoma mansoni kinase 0.0095 0.0081 0.0579
Echinococcus granulosus transmembrane protease serine 3 0.0176 0.0164 0.117
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0049 0.0294
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0002 0.0012
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0025 0.0149
Schistosoma mansoni hypothetical protein 0.0112 0.0099 0.0705
Onchocerca volvulus 0.0176 0.0164 0.2075
Plasmodium vivax hypothetical protein, conserved 0.0733 0.0735 1
Brugia malayi EGF-like domain containing protein 0.0223 0.0213 0.17
Giardia lamblia Cathepsin B precursor 0.006 0.0046 0.2089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0049 0.039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0061
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0026 0.1284
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0006 0.004
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0325 0.0317 0.0315
Schistosoma mansoni tyrosine kinase 0.0394 0.0388 0.2771
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Echinococcus granulosus neurogenic locus protein delta 0.0223 0.0213 0.1516
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0164 0.0988
Onchocerca volvulus 0.0041 0.0026 0.0305
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0009 0.0006
Plasmodium vivax vivapain-3 0.0041 0.0026 0.0326
Onchocerca volvulus Neurogenic locus notch homolog 0.0223 0.0213 0.2691
Giardia lamblia Kinesin-5 0.0083 0.0069 0.3205
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0003 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.003 0.0236
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0016 0.0195
Echinococcus multilocularis cathepsin b 0.0157 0.0144 0.0867
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0013 0.0074
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0045 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.0099 0.0592
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0026
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.005 0.0353
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0127 0.0906
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0034 0.0265
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0046 0.0275
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.0002 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0127 0.0762
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0059 0.0464
Schistosoma mansoni notch 0.0223 0.0213 0.152
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0026 0.0199
Brugia malayi EGF-like domain containing protein 0.0223 0.0213 0.17
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0026 0.0183
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0003 0.0022
Echinococcus multilocularis lamin 0.0027 0.0011 0.0064
Entamoeba histolytica hypothetical protein 0.0023 0.0007 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0017 0.0002 0.0002
Onchocerca volvulus 0.0041 0.0026 0.0305
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0026 0.0183
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0003 0.0019
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0059 0.0062
Schistosoma mansoni laminin gamma-3 chain 0.0223 0.0213 0.152
Brugia malayi Trypsin family protein 0.0176 0.0164 0.1312
Schistosoma mansoni cpg binding protein 0.0058 0.0043 0.0311
Brugia malayi conserved hypotetical protein 0.0021 0.0006 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0002 0.0014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0006 0.003
Brugia malayi Trypsin family protein 0.0176 0.0164 0.1312
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0001 0.0002
Giardia lamblia Kinase, PLK 0.0187 0.0175 0.8212
Brugia malayi beta-lactamase family protein 0.0073 0.0059 0.0464
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.003 0.0236
Echinococcus multilocularis Mastin 0.0176 0.0164 0.0988
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0019
Brugia malayi nuclear receptor NHR-88 0.0021 0.0006 0.004
Echinococcus multilocularis neurogenic locus notch protein 4 0.0223 0.0213 0.128
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0116
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Brugia malayi Cathepsin L-like cysteine proteinase 0.0017 0.0002 0.0008
Echinococcus granulosus smad 0.0041 0.0025 0.0177
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0022 0.015
Echinococcus multilocularis musashi 0.0027 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0113 0.0804
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0071 0.0567
Brugia malayi MH2 domain containing protein 0.0595 0.0593 0.4752
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0007 0.0005
Schistosoma mansoni notch 0.0223 0.0213 0.152
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Echinococcus granulosus Mastin 0.0176 0.0164 0.117
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0026 0.0513
Schistosoma mansoni nuclear hormone receptor 0.0045 0.003 0.0216
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0006 0.0052
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0016 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0175 0.3705
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0011 0.0062
Echinococcus granulosus geminin 0.067 0.067 0.4787
Toxoplasma gondii hypothetical protein 0.0317 0.0309 0.0611
Onchocerca volvulus 0.0024 0.0009 0.0087
Onchocerca volvulus Cathepsin F homolog 0.0041 0.0026 0.0305
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0003 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0045 0.0321
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1633 0.1656 1
Echinococcus granulosus lamin 0.0027 0.0011 0.0075
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0006 0.004
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0007 0.0076
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0071 0.0506
Leishmania major UDP-galactopyranose mutase 0.0733 0.0735 1
Toxoplasma gondii hypothetical protein 0.0317 0.0309 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.0002 0.0002
Toxoplasma gondii ABC1 family protein 0.0073 0.0059 0.0113
Mycobacterium ulcerans hypothetical protein 0.0073 0.0059 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0019
Echinococcus multilocularis lamin dm0 0.0027 0.0011 0.0064
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0013 0.0097
Onchocerca volvulus Slit protein homolog 0.0223 0.0213 0.2691
Onchocerca volvulus 0.003 0.0014 0.0163
Mycobacterium ulcerans lipase LipD 0.0073 0.0059 0.0056
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0002 0.0011
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0003 0.0017
Echinococcus multilocularis protein jagged 1 0.0223 0.0213 0.128
Onchocerca volvulus 0.0317 0.0309 0.3919
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0006 0.0036
Echinococcus granulosus slit 2 protein 0.0223 0.0213 0.1516
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0001 0.0002
Onchocerca volvulus 0.0317 0.0309 0.3919
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.0075 0.0599
Echinococcus multilocularis protein jagged 1 0.0223 0.0213 0.128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0061
Echinococcus granulosus expressed conserved protein 0.0187 0.0176 0.125
Brugia malayi CHE-14 protein 0.0085 0.0071 0.0567
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Echinococcus multilocularis dnaJ subfamily B 0.0829 0.0832 0.5024
Onchocerca volvulus 0.0073 0.0059 0.0725
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0008 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Brugia malayi MH1 domain containing protein 0.0022 0.0007 0.0049
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.9782 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0164 0.1175
Echinococcus granulosus protein jagged 1 0.0223 0.0213 0.1516
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0026 0.0348
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0046 0.0089
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0067 0.04
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.0188 1
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0013 0.0099
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0017 0.0002 0.0023
Entamoeba histolytica hypothetical protein 0.0035 0.002 0.0975
Echinococcus granulosus cathepsin L 0.0017 0.0002 0.0007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0176 0.0164 0.1175
Onchocerca volvulus 0.0081 0.0067 0.0832
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0049 0.039
Brugia malayi isocitrate dehydrogenase 0.0031 0.0016 0.0122
Loa Loa (eye worm) hypothetical protein 0.0047 0.0032 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.003 0.0236
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0009 0.0155
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0002 0.0011
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0003 0.0017
Entamoeba histolytica hypothetical protein 0.0035 0.002 0.0975
Schistosoma mansoni hypothetical protein 0.0223 0.0213 0.152
Mycobacterium tuberculosis Possible oxidoreductase 0.0733 0.0735 0.0793
Onchocerca volvulus 0.0045 0.003 0.0363
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0737 0.0739 0.1464
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0067 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.003 0.0236
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.002 0.0142
Schistosoma mansoni tyrosinase precursor 0.0089 0.0075 0.0539
Echinococcus multilocularis cathepsin b 0.0157 0.0144 0.0867
Brugia malayi cathepsin B-like cysteine proteinase 0.0157 0.0144 0.1151
Toxoplasma gondii microneme protein MIC17C 0.0317 0.0309 0.0611
Brugia malayi Cadherin domain containing protein 0.0223 0.0213 0.17
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0013 0.0097
Echinococcus multilocularis expressed conserved protein 0.0187 0.0176 0.1056
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0176 0.0164 0.117
Brugia malayi Furin-like cysteine rich region family protein 0.1234 0.1248 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0004 0.0018
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0016 0.0217
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0003 0.0014
Brugia malayi hypothetical protein 0.0024 0.0008 0.0061
Echinococcus granulosus cathepsin b 0.0157 0.0144 0.1026
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0002 0.0014
Schistosoma mansoni hypothetical protein 0.0021 0.0006 0.004
Brugia malayi EGF-like domain containing protein 0.0223 0.0213 0.17
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0059 0.1218
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0041 0.0026 0.0348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Schistosoma mansoni hypothetical protein 0.0082 0.0068 0.0488
Schistosoma mansoni hypothetical protein 0.0176 0.0164 0.1175
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0025 0.0177
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0017 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0063
Schistosoma mansoni cercarial elastase (S01 family) 0.0176 0.0164 0.1175
Schistosoma mansoni hypothetical protein 0.0829 0.0832 0.595
Brugia malayi Cadherin domain containing protein 0.0223 0.0213 0.17
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0049 0.0353
Onchocerca volvulus 0.0072 0.0058 0.0714
Brugia malayi Muscle positioning protein 4 0.0223 0.0213 0.17
Onchocerca volvulus 0.0021 0.0006 0.0052
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0002 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0059 0.1218
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0176 0.0164 0.1312
Brugia malayi notch-like transmembrane receptor 0.0223 0.0213 0.17
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0003 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0071 0.1493
Plasmodium vivax vivapain-2 0.0041 0.0026 0.0326
Loa Loa (eye worm) hypothetical protein 0.0176 0.0164 0.1312
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0002 0.0012
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0075 0.0599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.003 0.0236
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.0175 0.2381
Onchocerca volvulus 0.0317 0.0309 0.3919
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0175 0.3705
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0002 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0002 0.0002
Schistosoma mansoni tyrosine kinase 0.0663 0.0663 0.4738
Onchocerca volvulus 0.0041 0.0026 0.0305
Plasmodium falciparum phd finger protein, putative 0.0028 0.0013 0.0155
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0003 0.0017
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0013 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0175 0.3705
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0325 0.0317 0.0342
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0059 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0008
Echinococcus multilocularis epidermal growth factor receptor 0.0663 0.0663 0.4
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0006 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0009 0.0008
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.0446 0.2687
Echinococcus granulosus cathepsin L cysteine proteinase 0.0041 0.0026 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0175 0.3705
Loa Loa (eye worm) cathepsin B 0.006 0.0046 0.0361
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0016 0.0912
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.003 0.0211
Brugia malayi hypothetical protein 0.0021 0.0006 0.004
Echinococcus multilocularis smad 0.0041 0.0025 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0078 0.1644
Brugia malayi jmjC domain containing protein 0.004 0.0025 0.0191
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0325 0.0317 0.0315
Echinococcus granulosus neural cadherin 0.0223 0.0213 0.1516
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0059 0.0418
Loa Loa (eye worm) kinesin-like protein KLP2 0.0083 0.0069 0.055
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0006 0.004
Brugia malayi MH2 domain containing protein 0.0041 0.0025 0.0198
Onchocerca volvulus 0.0176 0.0164 0.2075
Brugia malayi nuclear receptor RXR 0.0024 0.0008 0.0061
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0002 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.003 0.0236
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0026 0.1284
Onchocerca volvulus 0.0089 0.0075 0.0941
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0045 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.067 0.067 0.479
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0007 0.0011
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.003 0.0363
Onchocerca volvulus 0.0089 0.0075 0.0941
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.003 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.003 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0127 0.0906
Echinococcus multilocularis cathepsin L cysteine protease 0.0041 0.0026 0.015
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0075 0.0599
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0016 0.0028
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0007 0.0005
Brugia malayi Heterochromatin protein 1 0.0068 0.0053 0.0423
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0059 0.3346
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0354 0.0347 0.2774
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0006 0.0041
Brugia malayi Trypsin family protein 0.0176 0.0164 0.1312
Echinococcus granulosus protein jagged 2 0.0223 0.0213 0.1516
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0071 0.0506
Echinococcus granulosus lysine specific histone demethylase 1A 0.0733 0.0735 0.525
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0045 0.0047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0016 0.0092
Loa Loa (eye worm) hypothetical protein 0.0176 0.0164 0.1312
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0063
Trypanosoma cruzi cysteine protease, putative 0.0041 0.0026 0.0348
Brugia malayi ShTK domain containing protein 0.0089 0.0075 0.0599
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0354 0.0347 0.2774
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0025 0.0175
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0006 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0025 0.0198
Plasmodium falciparum cysteine proteinase falcipain 1 0.0041 0.0026 0.0326
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0073 0.0059 0.0464
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.0002 0.0008
Leishmania major cathepsin L-like protease 0.0041 0.0026 0.0348
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0003 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0006 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0002 0.0008
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0026 0.0183
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0013 0.0086
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.0446 0.3181
Onchocerca volvulus 0.0223 0.0213 0.2691
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0192 0.0181 0.2285
Echinococcus granulosus cathepsin L cysteine protease 0.0041 0.0026 0.0178
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0079 0.0474
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0016 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0026 0.1461
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0009 0.0368
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0013
Brugia malayi hypothetical protein 0.0176 0.0164 0.1312
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0011 0.0074
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0001 0.0005
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0325 0.0317 0.4303
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.011
Echinococcus granulosus fibropellin Ia 0.0223 0.0213 0.1516
Loa Loa (eye worm) hypothetical protein 0.0733 0.0735 0.5888
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0041 0.0026 0.0348
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0059 0.0062
Brugia malayi cathepsin L-like precursor 0.0017 0.0002 0.0008
Echinococcus granulosus protein jagged 1 0.0223 0.0213 0.1516
Toxoplasma gondii PAN domain-containing protein 0.0317 0.0309 0.0611
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0733 0.0735 0.5253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.0002
Schistosoma mansoni Smad4 0.0018 0.0002 0.0018
Echinococcus multilocularis peregrin 0.0031 0.0016 0.0089
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.0006 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0002 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.003 0.0363
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0059 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.003 0.0236
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0007 0.0006
Brugia malayi nuclear receptor RXR 0.0021 0.0006 0.004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0008 0.0057
Echinococcus multilocularis insulin receptor 0.0394 0.0388 0.2338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0046 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.0046 0.0945
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0175 0.3705
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0002 0.0013
Plasmodium vivax vivapain-1 0.0041 0.0026 0.0326
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Loa Loa (eye worm) tyrosinase 1 0.0089 0.0075 0.0599
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0025 0.0171
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0075 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0032
Schistosoma mansoni Smad4 0.0041 0.0025 0.0182
Onchocerca volvulus 0.0223 0.0213 0.2691
Schistosoma mansoni hypothetical protein 0.0223 0.0213 0.152
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.0188 0.1501
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0003 0.0017
Echinococcus granulosus neurogenic locus notch protein 4 0.0223 0.0213 0.1516
Brugia malayi hypothetical protein 0.0019 0.0003 0.0019
Brugia malayi cathepsin L-like cysteine proteinase 0.0017 0.0002 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.0099 0.0592
Loa Loa (eye worm) hypothetical protein 0.0073 0.0059 0.0464
Onchocerca volvulus 0.0317 0.0309 0.3919
Schistosoma mansoni chromobox protein 0.0068 0.0053 0.0382
Loa Loa (eye worm) hypothetical protein 0.0234 0.0223 0.1785
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0059 0.0418
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.003 0.0211
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.0188 0.113
Echinococcus granulosus neurogenic locus notch protein 0.0223 0.0213 0.1516
Plasmodium vivax hypothetical protein, conserved 0.0733 0.0735 1
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Toxoplasma gondii cathepsin B 0.006 0.0046 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0213
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0064 0.0459
Brugia malayi Cytochrome P450 family protein 0.0049 0.0034 0.0265
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0004 0.0021
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0045 0.0086
Brugia malayi hypothetical protein 0.0019 0.0003 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0002 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0046 0.0327
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0026
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0009 0.0006
Brugia malayi PAN domain containing protein 0.0317 0.0309 0.2472
Brugia malayi nuclear hormone receptor 0.0021 0.0006 0.004
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.003 0.0236
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0003 0.0022
Schistosoma mansoni coup transcription factor 0.0045 0.003 0.0216
Mycobacterium ulcerans hypothetical protein 0.0176 0.0164 0.0162
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0022 0.0127
Brugia malayi PHD-finger family protein 0.0029 0.0014 0.0103
Loa Loa (eye worm) hypothetical protein 0.0081 0.0067 0.0531
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0003 0.0022
Trypanosoma cruzi UDP-galactopyranose mutase 0.0733 0.0735 1
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0026 0.0348
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0003 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0026 0.1284
Onchocerca volvulus 0.0176 0.0164 0.2075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0013
Echinococcus granulosus neuropeptide s receptor 0.0451 0.0446 0.3181
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Schistosoma mansoni notch 0.0223 0.0213 0.152
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0041 0.0026 0.0513
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.0446 0.2687
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0013 0.0073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0043 0.0343
Brugia malayi hypothetical protein 0.0234 0.0223 0.1785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0026 0.0513
Loa Loa (eye worm) hypothetical protein 0.0317 0.0309 0.2472
Mycobacterium ulcerans oxidoreductase 0.0733 0.0735 0.0733
Onchocerca volvulus 0.0041 0.0026 0.0305
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0006 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.004
Echinococcus multilocularis neurogenic locus protein delta 0.0223 0.0213 0.128
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0067 0.0473
Schistosoma mansoni thyroid hormone receptor 0.0045 0.003 0.0216
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.0144 0.1031
Brugia malayi chromobox protein homolog 3 0.0038 0.0023 0.0178
Toxoplasma gondii PAN domain-containing protein 0.4933 0.5035 1
Echinococcus granulosus GPCR family 2 0.0112 0.0099 0.0701
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0084
Echinococcus multilocularis neurogenic locus notch protein 0.0223 0.0213 0.128
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0003 0.0019
Onchocerca volvulus 0.0733 0.0735 0.935
Echinococcus granulosus cathepsin l1 0.0017 0.0002 0.0007
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0009 0.0368
Schistosoma mansoni amine oxidase 0.0733 0.0735 0.5253
Trichomonas vaginalis esterase, putative 0.0073 0.0059 0.1218
Onchocerca volvulus 0.0317 0.0309 0.3919
Brugia malayi ecdysone receptor 0.0021 0.0006 0.004
Echinococcus multilocularis 0.0733 0.0735 0.4434
Trypanosoma cruzi UDP-galactopyranose mutase 0.0733 0.0735 1
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0027 0.1371
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0058 0.0412
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0002 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0733 0.0735 0.0793
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.003 0.0216
Loa Loa (eye worm) hypothetical protein 0.0223 0.0213 0.17
Toxoplasma gondii microneme protein MIC17A 0.0317 0.0309 0.0611
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0236
Leishmania major hypothetical protein, conserved 0.0073 0.0059 0.0797
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0026 0.0183
Entamoeba histolytica cysteine protease, putative 0.0041 0.0026 0.1284
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0006 0.0036
Onchocerca volvulus 0.0317 0.0309 0.3919
Plasmodium falciparum protoporphyrinogen oxidase 0.0733 0.0735 1
Schistosoma mansoni hypothetical protein 0.0223 0.0213 0.152
Loa Loa (eye worm) hypothetical protein 0.0049 0.0034 0.0266
Echinococcus granulosus protein jagged 2 0.0223 0.0213 0.1516
Brugia malayi CXXC zinc finger family protein 0.0058 0.0043 0.0343
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0009 0.0017
Brugia malayi MH1 domain containing protein 0.0041 0.0025 0.0198
Loa Loa (eye worm) notch protein 0.0223 0.0213 0.17
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0317 0.0309 0.2472
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.0411 0.3289

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.57 nM Effective concentration for mouse Melanocortin-4 receptor ChEMBL. 15828845
EC50 (binding) = 3.13 nM Effective concentration for mouse Melanocortin-5 receptor ChEMBL. 15828845
EC50 (binding) = 5.56 nM Effective concentration for mouse Melanocortin-1 receptor ChEMBL. 15828845
EC50 (binding) = 9.2 nM Effective concentration for mouse Melanocortin-1 receptor ChEMBL. 15828845
EC50 (binding) = 22.3 nM Effective concentration for mouse Melanocortin-5 receptor ChEMBL. 15828845
EC50 (binding) = 320 nM Effective concentration for mouse Melanocortin-3 receptor ChEMBL. 15828845
pA2 (functional) = 8.2 nM Antagonist activity for mouse Melanocortin-3 receptor ChEMBL. 15828845
pA2 (functional) = 9.1 nM Partial agonist concentration for mouse Melanocortin-4 receptor ChEMBL. 15828845
Selectivity ratio (binding) = 560 Relative effective concentration for Melanocortin-3 and Melanocortin-4 receptors ChEMBL. 15828845

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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