Detailed information for compound 500455

Basic information

Technical information
  • TDR Targets ID: 500455
  • Name: 1-(3-amino-1,2-benzoxazol-5-yl)-5-[6-(2-oxoaz epan-1-yl)-2,3-dihydroindole-1-carbonyl]pyraz ole-3-carboxamide
  • MW: 499.521 | Formula: C26H25N7O4
  • H donors: 2 H acceptors: 5 LogP: 2.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)c1cc(n(n1)c1ccc2c(c1)c(N)no2)C(=O)N1CCc2c1cc(cc2)N1CCCCCC1=O
  • InChi: 1S/C26H25N7O4/c27-24-18-12-17(7-8-22(18)37-30-24)33-21(14-19(29-33)25(28)35)26(36)32-11-9-15-5-6-16(13-20(15)32)31-10-3-1-2-4-23(31)34/h5-8,12-14H,1-4,9-11H2,(H2,27,30)(H2,28,35)
  • InChiKey: DBTTUHJNJGMINA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-amino-1,2-benzoxazol-5-yl)-5-[6-(2-oxoazepan-1-yl)indoline-1-carbonyl]pyrazole-3-carboxamide
  • 1-(3-amino-1,2-benzoxazol-5-yl)-5-[oxo-[6-(2-oxo-1-azepanyl)-1-indolinyl]methyl]-3-pyrazolecarboxamide
  • 1-(3-azanyl-1,2-benzoxazol-5-yl)-5-[[6-(2-oxoazepan-1-yl)-2,3-dihydroindol-1-yl]carbonyl]pyrazole-3-carboxamide
  • 1-(3-aminoindoxazen-5-yl)-5-[6-(2-ketoazepan-1-yl)indoline-1-carbonyl]pyrazole-3-carboxamide
  • 1-(3-amino-1,2-benzoxazol-5-yl)-5-[6-(2-oxoazepan-1-yl)2,3-dihydroindole-1-carbonyl]pyrazole-3-carboxamide
  • 1-(3-amino-1,2-benzoxazol-5-yl)-5-[[6-(2-oxoazepan-1-yl)-2,3-dihydroindol-1-yl]carbonyl]pyrazole-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.002 0.0012
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.035 0.1005
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0203 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0291 0.1607
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0787 0.078
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Plasmodium falciparum glutathione reductase 0.0032 0.0345 0.1324
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Loa Loa (eye worm) hypothetical protein 0.0028 0.0284 0.0457
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0027 0.0075
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.009 0.0082
Echinococcus multilocularis dna polymerase eta 0.0033 0.0356 0.0348
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0011 0.002 0.0017
Trypanosoma brucei unspecified product 0.0052 0.065 0.1496
Echinococcus granulosus carbonyl reductase 1 0.0011 0.002 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0266 0.0375
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0011 0.002 0.0027
Schistosoma mansoni pyruvate kinase 0.0017 0.0111 0.0103
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0245 0.0237
Echinococcus granulosus oxidoreductase 0.0011 0.002 0.0012
Echinococcus multilocularis chromobox protein 1 0.0067 0.0884 0.0876
Trypanosoma brucei hypothetical protein 0.011 0.1526 0.3539
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0345 0.0784
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0747 0.1075
Loa Loa (eye worm) hypothetical protein 0.0052 0.0658 0.1079
Brugia malayi Dihydrofolate reductase 0.0051 0.0639 0.1048
Echinococcus multilocularis steroid dehydrogenase 0.0011 0.002 0.0012
Toxoplasma gondii carbonyl reductase 1, putative 0.0011 0.002 0.0078
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0255 0.0575
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0884 0.1274
Echinococcus multilocularis conserved hypothetical protein 0.0011 0.002 0.0012
Plasmodium vivax pyruvate kinase, putative 0.0032 0.035 0.1345
Loa Loa (eye worm) thymidylate synthase 0.0126 0.177 0.2927
Plasmodium falciparum thioredoxin reductase 0.0092 0.1259 0.4923
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0427
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0356 0.1964
Echinococcus multilocularis laminin 0.0016 0.0105 0.0097
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0011 0.002 0.0017
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.011 0.1526 0.3539
Trypanosoma cruzi metacaspase, putative 0.0026 0.0255 0.0575
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.002 0.0109
Schistosoma mansoni caspase-3 (C14 family) 0.0097 0.1338 0.1331
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Leishmania major pyruvate kinase 0.0032 0.035 0.0797
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.1603 0.1596
Echinococcus multilocularis geminin 0.0164 0.235 0.2343
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Echinococcus granulosus phd:f box containing protein 0.0015 0.009 0.0082
Schistosoma mansoni carbonyl reductase 0.0011 0.002 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0311 0.0705
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Brugia malayi jmjC domain containing protein 0.0057 0.0724 0.1189
Brugia malayi RNA, U transporter 1 0.0079 0.1065 0.1755
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.021
Loa Loa (eye worm) hypothetical protein 0.0146 0.2084 0.345
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1457 0.8037
Echinococcus granulosus hypothetical protein 0.0011 0.002 0.0012
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0255 0.1001
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0097 0.1338 0.1331
Echinococcus multilocularis dihydrofolate reductase 0.0051 0.0639 0.0631
Echinococcus multilocularis lamin dm0 0.0052 0.0658 0.065
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0011 0.002 0.0027
Toxoplasma gondii hypothetical protein 0.0047 0.0576 0.2258
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.1457 0.2407
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0299 0.0678
Loa Loa (eye worm) tumor suppressor 0.0315 0.4649 0.7711
Brugia malayi thymidylate synthase 0.0126 0.177 0.2927
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Leishmania major short chain dehydrogenase-like protein 0.0011 0.002 0.0027
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.0311 0.119
Schistosoma mansoni hypothetical protein 0.0027 0.0265 0.0257
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Echinococcus granulosus hypothetical protein 0.0027 0.0265 0.0257
Leishmania major DNA polymerase kappa, putative 0.001 0.0014 0.0013
Mycobacterium ulcerans dehydrogenase/reductase 0.0011 0.002 0.0053
Brugia malayi hypothetical protein 0.001 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.035 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0266 0.0375
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.0311 0.1219
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0366 0.0521
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0345 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0724 0.0716
Echinococcus granulosus protein quaking 0.0027 0.0265 0.0257
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0027 0.0032
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0216 0.0484
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0291 0.1114
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0128 0.1813 0.1806
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 1
Trichomonas vaginalis set domain proteins, putative 0.0461 0.6877 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0388 0.038
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0026 0.0018
Schistosoma mansoni intermediate filament proteins 0.0052 0.0658 0.065
Echinococcus multilocularis muscleblind protein 0.0146 0.2084 0.2078
Giardia lamblia DINP protein human, muc B family 0.0039 0.0453 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Plasmodium vivax metacaspase 1, putative 0.0026 0.0255 0.0971
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0356 0.0578
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0752 0.0745
Loa Loa (eye worm) hypothetical protein 0.0133 0.1885 0.3119
Echinococcus granulosus pyruvate kinase 0.0032 0.035 0.0342
Schistosoma mansoni DNA polymerase IV / kappa 0.001 0.0014 0.0006
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0027
Giardia lamblia Hypothetical protein 0.0011 0.002 0.0137
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.0103
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Mycobacterium ulcerans short-chain type oxidoreductase 0.0011 0.002 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0255 0.0971
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0168 0.0731
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0128 0.1813 0.1806
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0027 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.092 0.0912
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0011 0.002 0.0034
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0014 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0405 0.0924
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Echinococcus multilocularis ubiquitin 0.001 0.0018 0.0009
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0011 0.002 0.0034
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0105 0.0161
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0011 0.002 0.0027
Entamoeba histolytica hypothetical protein 0.0023 0.0203 0.1122
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Schistosoma mansoni lamin 0.0052 0.0658 0.065
Entamoeba histolytica pyruvate kinase, putative 0.0022 0.0202 0.1112
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0356 0.0348
Trypanosoma brucei unspecified product 0.0023 0.0202 0.0452
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0011 0.002 0.0053
Schistosoma mansoni hypothetical protein 0.0395 0.587 0.5867
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.035 0.0497
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0287 0.0463
Schistosoma mansoni protein phosphatase 2C 0.0015 0.009 0.0082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0028
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0216 0.0484
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.1259 0.3679
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0356 0.0348
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0128 0.1813 0.4207
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0484 0.1109
Brugia malayi glutathione reductase 0.0092 0.1259 0.2078
Schistosoma mansoni importin beta-1 0.0028 0.0284 0.0275
Toxoplasma gondii oxidoreductase, putative 0.0011 0.002 0.0078
Echinococcus multilocularis fibrillin 1 0.0016 0.0105 0.0097
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0027 0.0075
Entamoeba histolytica hypothetical protein 0.0011 0.0027 0.0151
Echinococcus granulosus thymidylate synthase 0.0126 0.177 0.1763
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0345 0.1324
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Loa Loa (eye worm) dihydrofolate reductase 0.0051 0.0639 0.1047
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1073 0.5921
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0011 0.002 0.0034
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0011 0.002 0.0019
Echinococcus multilocularis oxidoreductase 0.0011 0.002 0.0012
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.002 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0126 0.177 0.5182
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0291 0.6318
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0172 0.0163
Onchocerca volvulus 0.0011 0.002 0.0017
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0097 0.1338 0.1331
Brugia malayi dihydrofolate reductase family protein 0.0051 0.0639 0.1048
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0011 0.002 0.0034
Trichomonas vaginalis ubiquitin, putative 0.001 0.0018 0.0013
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0011 0.002 0.0027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.3051 0.8952
Echinococcus multilocularis pyruvate kinase 0.0025 0.0247 0.0239
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0168 0.0373
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Echinococcus multilocularis caspase 0.0097 0.1338 0.1331
Onchocerca volvulus 0.0028 0.0282 0.0398
Echinococcus granulosus GPCR family 2 0.0015 0.0092 0.0083
Loa Loa (eye worm) dehydrogenase 0.0011 0.002 0.0019
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.035 0.0797
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.1259 0.1252
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Mycobacterium tuberculosis Hypothetical protein 0.006 0.0768 0.2236
Loa Loa (eye worm) pyruvate kinase 0.0032 0.035 0.0568
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.009 0.0191
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0345 0.049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0692 0.2714
Loa Loa (eye worm) dehydrogenase 0.0011 0.002 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0168 0.0731
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0216 0.0345
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.0103
Brugia malayi tumor suppressor. 0.0315 0.4649 0.7711
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0011 0.002 0.0078
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.001 0.0008 0.0033
Loa Loa (eye worm) glutathione reductase 0.0092 0.1259 0.2078
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.009 0.0191
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Schistosoma mansoni ran 0.0021 0.0172 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0299 0.0678
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0105 0.0161
Echinococcus granulosus carbonyl reductase 1 0.0011 0.002 0.0012
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.001 0.0008 0.0033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.009 0.0136
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.009 0.0323
Leishmania major 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0027
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0356 0.0348
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0402 0.0394
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.0202 0.0321
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0111 0.0406
Schistosoma mansoni chromobox protein 0.0067 0.0884 0.0876
Mycobacterium ulcerans oxidoreductase 0.0011 0.002 0.0053
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.3051 0.8952
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Echinococcus multilocularis cpg binding protein 0.0029 0.0306 0.0298
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0051 0.0043
Mycobacterium leprae Probable oxidoreductase 0.0011 0.002 0.0034
Schistosoma mansoni jumonji domain containing protein 0.0015 0.009 0.0082
Entamoeba histolytica ubiquitin like protein 0.003 0.0311 0.1713
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.002 0.0053
Loa Loa (eye worm) RecQ helicase 0.0044 0.0526 0.086
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.006 0.0768 0.1772
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0172 0.3593
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0299 0.0678
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0011 0.002 0.0034
Schistosoma mansoni DNA helicase recq5 0.0018 0.0135 0.0127
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0356 0.0811
Echinococcus granulosus ubiquitin 0.001 0.0018 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0092 0.0139
Schistosoma mansoni cpg binding protein 0.0029 0.0306 0.0298
Plasmodium falciparum pyruvate kinase 0.0032 0.035 0.1345
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.009 0.0082
Echinococcus granulosus pyruvate kinase 0.0032 0.035 0.0342
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0011 0.002 0.0017
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0284 0.0642
Onchocerca volvulus 0.0052 0.0658 0.0945
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0356 0.1023
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Trypanosoma brucei Metacaspase-4 0.0026 0.0255 0.0575
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0291 0.1114
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0135 0.021
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0526 0.0861
Brugia malayi Retinol dehydrogenase 12 0.0011 0.002 0.0019
Onchocerca volvulus 0.001 0.0018 0.0013
Brugia malayi 6-phosphofructokinase 0.0105 0.1457 0.2407
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0658 0.1079
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.002 0.0168 0.0731
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.1656 0.1649
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 0.5922
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1457 0.8037
Trypanosoma cruzi short chain dehydrogenase, putative 0.0011 0.002 0.0027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Trypanosoma brucei metacaspase 0.0026 0.0255 0.0575
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0051 0.0639 0.1854
Brugia malayi hypothetical protein 0.0027 0.0265 0.0427
Loa Loa (eye worm) hypothetical protein 0.0033 0.0361 0.0585
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0345 0.1536
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0402 0.0394
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.1603 0.4691
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.1656 0.1649
Echinococcus granulosus chromobox protein 1 0.0067 0.0884 0.0876
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0011 0.002 0.0012
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.4298 1
Brugia malayi jmjC domain containing protein 0.0015 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.1338 0.1331
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0784
Mycobacterium ulcerans ketoacyl reductase 0.0011 0.002 0.0053
Mycobacterium ulcerans oxidoreductase 0.0011 0.002 0.0053
Plasmodium vivax SET domain protein, putative 0.0059 0.0752 0.2929
Echinococcus granulosus caspase 8 0.0026 0.0255 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Schistosoma mansoni hypothetical protein 0.0164 0.235 0.2343
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.1457 0.3377
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Echinococcus multilocularis musashi 0.0052 0.0658 0.065
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0011 0.002 0.0109
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0345 0.1352
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Echinococcus granulosus dihydrofolate reductase 0.0051 0.0639 0.0631
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0747 0.1075
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0128 0.1813 0.2998
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0011 0.002 0.0343
Echinococcus granulosus geminin 0.0164 0.235 0.2343
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0126 0.177 0.5182
Echinococcus multilocularis lamin 0.0052 0.0658 0.065
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0453 0.1308
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0747 0.1722
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0255 0.0247
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0092 0.0083
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.1457 0.2407
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0291 0.449
Mycobacterium ulcerans ketoacyl reductase 0.0011 0.002 0.0053
Trichomonas vaginalis ran, putative 0.0021 0.0172 0.0238
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0105 0.0097
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.3051 0.8952
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Onchocerca volvulus 0.0011 0.002 0.0017
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0011 0.002 0.0027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0203 0.0284
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0526 0.0518
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0345 0.1324
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0105 0.0413
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0015
Schistosoma mansoni microtubule-associated protein tau 0.0667 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0011 0.002 0.0027
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.035 0.1005
Plasmodium vivax JmjC domain containing protein 0.0015 0.009 0.0323
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.0311 0.0303
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trypanosoma cruzi metacaspase, putative 0.0026 0.0255 0.0575
Mycobacterium ulcerans ketoacyl reductase 0.0011 0.002 0.0053
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0027 0.0019
Schistosoma mansoni lamin 0.0052 0.0658 0.065
Schistosoma mansoni DNA polymerase eta 0.0033 0.0356 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.1457 0.3377
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0255 0.0575
Echinococcus multilocularis retinol dehydrogenase 11 0.0011 0.002 0.0012
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0135 0.0127
Entamoeba histolytica hypothetical protein 0.0011 0.002 0.0109
Schistosoma mansoni ran 0.0021 0.0172 0.0163
Schistosoma mansoni cpg binding protein 0.0029 0.0306 0.0298
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0105 0.0097
Echinococcus granulosus retinol dehydrogenase 11 0.0011 0.002 0.0012
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.1603 0.1596
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.1603 0.7284
Echinococcus multilocularis pyruvate kinase 0.0032 0.035 0.0342
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0128 0.1813 0.1806
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.0103
Trichomonas vaginalis hypothetical protein 0.0011 0.0027 0.0028
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.0103
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0105 0.0161
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0015
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Schistosoma mansoni carbonyl reductase 0.0011 0.002 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0434 0.0619
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.023 0.0517
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0369
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0027 0.0019
Trypanosoma brucei unspecified product 0.0023 0.0202 0.0452
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0369
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0172 0.0381
Echinococcus multilocularis retinol dehydrogenase 11 0.0011 0.002 0.0012
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0345 0.5335
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0453 0.1037
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0014 0.0013
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0011 0.002 0.0027
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.009 0.0082
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0345 0.1536
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0592 0.0971
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0255 0.0359
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0011 0.002 0.0027
Trypanosoma cruzi metacaspase, putative 0.0026 0.0255 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0578
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.0103
Schistosoma mansoni retinal dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Plasmodium vivax DNA repair protein REV1, putative 0.001 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.1457 0.145
Entamoeba histolytica short chain dehydrogenase family protein 0.0011 0.002 0.0109
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.0667 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0092 0.0139
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0255 0.0575
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0105 0.0413
Giardia lamblia Short-chain dehydrogenase, putative 0.0011 0.002 0.0137
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.062 0.1427
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.4383 0.7269
Echinococcus granulosus lamin 0.0052 0.0658 0.065
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.023 0.0873
Mycobacterium ulcerans dehydrogenase 0.0011 0.002 0.0053
Loa Loa (eye worm) SMO-1 protein 0.003 0.0311 0.0502
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Onchocerca volvulus 0.0011 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0168 0.0471
Plasmodium falciparum metacaspase 1 0.0026 0.0255 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.002 0.0168 0.0661
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0011 0.002 0.0027
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.196 0.455
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.001 0.0008 0.0046
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.1603 0.1596
Loa Loa (eye worm) hypothetical protein 0.003 0.031 0.0501
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0011 0.002 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0011 0.002 0.0034
Leishmania major trypanothione reductase 0.0092 0.1259 0.2915
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.002 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Echinococcus granulosus dna polymerase kappa 0.0058 0.0747 0.0739
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.4298 1
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0083
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0027 0.0019
Schistosoma mansoni chromobox protein 0.0011 0.0027 0.0019
Leishmania major small ubiquitin protein, putative 0.003 0.0311 0.0705
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.3051 0.8952
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Echinococcus multilocularis thymidylate synthase 0.0126 0.177 0.1763
Mycobacterium tuberculosis Possible oxidoreductase 0.0011 0.002 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0434 0.0619
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0233 0.3407 1
Loa Loa (eye worm) helicase 0.0011 0.0027 0.0032
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0126 0.177 0.1763
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.009 0.0136
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0135 0.0529
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0128 0.1813 0.2999
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.023 0.0517
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0291 0.1143
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.035 0.0568
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0345 0.0784
Leishmania major oxidoreductase-like protein 0.002 0.0168 0.0373
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0405 0.6027 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Mycobacterium tuberculosis Probable dehydrogenase 0.0011 0.002 0.0034
Onchocerca volvulus 0.0461 0.6877 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0291 0.0412
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Brugia malayi 6-phosphofructokinase 0.0105 0.1457 0.2407
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.035 0.1373
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.1813 0.4207
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0105 0.0161
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0011 0.002 0.0027
Echinococcus granulosus caspase 2 0.0026 0.0255 0.0247
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 0.5922
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0092 0.0083
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.0311 0.0303
Schistosoma mansoni hypothetical protein 0.0011 0.0027 0.0019
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.1813 0.4207
Trypanosoma brucei trypanothione reductase 0.0092 0.1259 0.2915
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.001 0.0008 0.0033
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0128 0.1813 1
Brugia malayi Heterochromatin protein 1 0.0067 0.0884 0.1455
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0369
Entamoeba histolytica short chain dehydrogenase family protein 0.0011 0.002 0.0109
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Loa Loa (eye worm) pyruvate kinase 0.0032 0.035 0.0568
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.0311 0.0303
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0011 0.002 0.0078
Echinococcus granulosus dna polymerase eta 0.0033 0.0356 0.0348
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0027 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1656 0.7528
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0291 0.1143
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0135 0.2756
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0031 0.033 0.0535
Echinococcus granulosus lamin dm0 0.0052 0.0658 0.065
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.009 0.0082
Leishmania major short chain dehydrogenase, putative 0.0011 0.002 0.0027
Echinococcus granulosus snurportin 1 0.0297 0.4383 0.4378
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0151
Trypanosoma brucei chrX additional, unordered contigs 0.001 0.0014 0.0013
Brugia malayi jmjC domain containing protein 0.0015 0.009 0.0136
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0216 0.0302
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0027 0.0028
Onchocerca volvulus 0.0011 0.002 0.0017
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.065 0.1496
Brugia malayi jmjC domain containing protein 0.0015 0.009 0.0136
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0388 0.038
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0011 0.002 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0752 0.2952
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0172 0.0381
Loa Loa (eye worm) hypothetical protein 0.008 0.1073 0.177
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0135 0.0127
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Brugia malayi hypothetical protein 0.0011 0.002 0.0019
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0011 0.002 0.0034
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0366 0.0521
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.1457 0.3377
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1656 0.7528
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.2143
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0297 0.4383 0.4378
Echinococcus multilocularis chromobox protein 1 0.0067 0.0884 0.0876
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.1603 0.3717
Brugia malayi Thioredoxin reductase 0.0092 0.1259 0.2078
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0356 0.0578
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.1457 0.145
Entamoeba histolytica hypothetical protein 0.001 0.0018 0.0097
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0118 0.1656 0.1649
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2197 0.6441
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0072 0.0092
Mycobacterium ulcerans pyruvate kinase 0.0032 0.035 0.1561
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0014 0.0013
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.009 0.0082
Onchocerca volvulus 0.0011 0.002 0.0017
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0083
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0027 0.0032
Treponema pallidum NADH oxidase 0.0032 0.0345 0.0457
Leishmania major pteridine reductase 1 0.0238 0.3474 0.808
Giardia lamblia Sentrin 0.003 0.0311 0.6757
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0752 0.0745
Brugia malayi Pre-SET motif family protein 0.0059 0.0752 0.1236
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0135 0.0127
Onchocerca volvulus 0.0011 0.002 0.0017
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0027
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0011 0.002 0.0017
Brugia malayi Cell death protein 3 precursor 0.0026 0.0255 0.041
Trypanosoma brucei metacaspase MCA3 0.0026 0.0255 0.0575
Onchocerca volvulus 0.0011 0.0027 0.0028
Echinococcus granulosus Chromo domain 0.0011 0.0027 0.0019
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.031 0.1189
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0203 0.0284
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Mycobacterium ulcerans hypothetical protein 0.001 0.0014 0.0025
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.009 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0752 0.0745
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0291 0.1114
Mycobacterium tuberculosis Probable oxidoreductase 0.0233 0.3407 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0051 0.0639 0.1854
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0017 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Onchocerca volvulus Arrow homolog 0.0016 0.0105 0.0141
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0011 0.002 0.0012
Echinococcus granulosus carbonyl reductase 1 0.0011 0.002 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0434 0.0619
Onchocerca volvulus 0.0011 0.0027 0.0028
Schistosoma mansoni hypothetical protein 0.0011 0.0026 0.0018
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Giardia lamblia Pyruvate kinase 0.0017 0.0111 0.2222
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0011 0.002 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0345 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0017 0.0009
Schistosoma mansoni hypothetical protein 0.0035 0.0388 0.038
Echinococcus multilocularis retinol dehydrogenase 13 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.009 0.0354
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0216 0.119
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0027 0.0107
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0484 0.1109
Echinococcus granulosus chromobox protein 2 0.0011 0.0027 0.0019
Echinococcus granulosus laminin 0.0016 0.0105 0.0097
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0172 0.0673
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0111 0.0437
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0748 0.1229
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0027 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.035 0.0497
Loa Loa (eye worm) phosphofructokinase 0.0105 0.1457 0.2407
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0216 0.0345
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0011 0.002 0.0017
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.009 0.0354
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0011 0.002 0.0034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0114 0.0106
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.002 0.0012
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Trypanosoma cruzi calpain cysteine peptidase, putative 0.011 0.1526 0.3539
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0345 0.0989
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0011 0.002 0.0019
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0014 0.0013
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Toxoplasma gondii thioredoxin reductase 0.0092 0.1259 0.4939
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0255 0.0247
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0784
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0282 0.0454
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0011 0.002 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Trypanosoma brucei calpain-like protein, putative 0.011 0.1526 0.3539
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0011 0.002 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.1603 0.7284
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0172 0.0643
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0172 0.0643
Trypanosoma brucei metacaspase MCA2 0.0026 0.0255 0.0575
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Leishmania major DNA polymerase kappa, putative 0.0039 0.0453 0.1037
Leishmania major dehydrogenase-like protein 0.0011 0.002 0.0027
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0016 0.0111 0.0435
Trypanosoma cruzi DNA polymerase eta, putative 0.001 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 0.5922
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0484 0.1109
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0011 0.002 0.0034
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Echinococcus granulosus caspase 0.0097 0.1338 0.1331
Schistosoma mansoni egf-like domain protein 0.0016 0.0105 0.0097
Echinococcus granulosus WW domain containing oxidoreductase 0.0011 0.002 0.0012
Echinococcus multilocularis GPCR, family 2 0.0015 0.0092 0.0083
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.1813 0.4207
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0014 0.0013
Brugia malayi phosphofructokinase 0.0105 0.1457 0.2407
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0092 0.0083
Echinococcus multilocularis phd:f box containing protein 0.0015 0.009 0.0082
Brugia malayi hypothetical protein 0.0024 0.023 0.0369
Brugia malayi Importin beta-1 subunit 0.0028 0.0284 0.0458
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.002 0.0045
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.1457 0.6618
Mycobacterium ulcerans carveol-like dehydrogenase 0.0011 0.002 0.0053
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Brugia malayi SET domain containing protein 0.0014 0.0069 0.0101
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0138
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0105 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0752 0.0745
Mycobacterium ulcerans thymidylate synthase 0.0126 0.177 0.8047
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.002 0.0012
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.0103
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0884 0.1274
Brugia malayi polk-prov protein 0.0036 0.0405 0.0659
Leishmania major importin beta-1 subunit, putative 0.0023 0.0203 0.0455
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0311 0.044
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.1591 0.263
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0345 0.0784
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0092 0.0138
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Brugia malayi Muscleblind-like protein 0.0146 0.2084 0.345
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0291 0.449
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.1259 0.4923
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0011 0.002 0.0034
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0111 0.0406
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0484 0.1109
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0747 0.3374
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0083
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Echinococcus granulosus bloom syndrome protein 0.0044 0.0526 0.0518
Echinococcus multilocularis chromobox protein 2 0.0011 0.0027 0.0019
Leishmania major hypothetical protein, conserved 0.0015 0.009 0.0191
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0118 0.1656 0.1649
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Schistosoma mansoni chromobox protein 0.0011 0.0027 0.0019
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0477 0.0683
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0011 0.002 0.0027
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0023 0.0024
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Brugia malayi jmjC domain containing protein 0.0058 0.0748 0.1229
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0114 0.0106
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0748 0.074
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0011 0.002 0.0053
Chlamydia trachomatis dihydrofolate reductase 0.0051 0.0639 1
Entamoeba histolytica hypothetical protein 0.0011 0.0027 0.0151
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0135 0.0127
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4298 1
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0027 0.0032
Brugia malayi Protein cec-1. 0.0011 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0164 0.235 0.2343
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0202 0.0321
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0356 0.0811
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0592 0.0971
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.035 0.0797
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0356 0.0578
Onchocerca volvulus 0.0011 0.002 0.0017
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.2143
Plasmodium falciparum steroid dehydrogenase, putative 0.0011 0.002 0.0045
Onchocerca volvulus 0.0011 0.002 0.0017
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0027 0.0032
Brugia malayi CXXC zinc finger family protein 0.0028 0.0282 0.0455
Loa Loa (eye worm) hypothetical protein 0.0026 0.0255 0.041
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.0311 0.0503
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Echinococcus multilocularis Chromo domain 0.0011 0.0027 0.0019
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.1457 0.145
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0345 0.0784
Plasmodium vivax importin-beta 2, putative 0.0028 0.0284 0.1083
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Echinococcus granulosus retinol dehydrogenase 11 0.0011 0.002 0.0012
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0452 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.002 0.0109
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Echinococcus multilocularis pyruvate kinase 0.0032 0.035 0.0342
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0345 0.1352
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0337
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0345 0.1536
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.1259 0.2078
Schistosoma mansoni cpg binding protein 0.0028 0.0282 0.0274
Brugia malayi hypothetical protein 0.0016 0.0099 0.0151
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0051 0.0072
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0011 0.002 0.0012
Onchocerca volvulus Sepiapterin reductase homolog 0.0011 0.002 0.0017
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0151
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0345 0.0784
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1457 0.2109
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0014 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0747 0.1722
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0311 0.0705
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.1457 0.4262
Leishmania major pyruvate kinase 0.0032 0.035 0.0797
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0135 0.0529
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0135 0.0498
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.021 0.3051 0.8952
Entamoeba histolytica hypothetical protein 0.0011 0.0027 0.0151
Echinococcus multilocularis caspase 3 0.0071 0.0943 0.0935
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0011 0.002 0.0034
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Echinococcus granulosus caspase 3 0.0071 0.0943 0.0935
Plasmodium falciparum metacaspase-like protein 0.0026 0.0255 0.0971
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0017 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0748 0.074
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0027 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Onchocerca volvulus 0.0052 0.0658 0.0945
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0168 0.0731
Onchocerca volvulus 0.0011 0.002 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0018 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0388 0.038
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Trichomonas vaginalis steroid dehydrogenase, putative 0.0011 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0752 0.1236
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0284 0.0275
Echinococcus multilocularis transcription factor Dp 1 0.0074 0.099 0.0983
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.0311 0.119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Echinococcus granulosus importin subunit beta 1 0.0028 0.0284 0.0275
Schistosoma mansoni dihydrofolate reductase 0.0051 0.0639 0.0631
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Onchocerca volvulus 0.003 0.031 0.0439
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1457 0.2109
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0079 0.0102
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0136
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.196 0.455
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.035 0.0497
Brugia malayi jmjC domain containing protein 0.0015 0.009 0.0136
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0477 0.0683
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Entamoeba histolytica Ran family GTPase 0.0021 0.0172 0.0947
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.196 0.455
Leishmania major DNA polymerase eta, putative 0.001 0.0014 0.0013
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0014 0.0013
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.0311 0.0705
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0011 0.002 0.0034
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0402 0.0654
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0658 0.1079
Plasmodium vivax hypothetical protein, conserved 0.0011 0.002 0.0045
Leishmania major metacaspase, putative 0.0026 0.0255 0.0575
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.2143
Schistosoma mansoni carbonyl reductase 0.0011 0.002 0.0012
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0135 0.0211
Leishmania major DNA damage repair protein, putative 0.001 0.0014 0.0013
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0284 0.0642
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0011 0.002 0.0017
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Echinococcus granulosus voltage gated potassium channel 0.001 0.0017 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.587 0.5867
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.1603 0.265
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Chlamydia trachomatis pyruvate kinase 0.0032 0.035 0.5421
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0177 0.2549 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0172 0.0271
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.009 0.0082
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.1457 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0402 0.0654
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0014 0.0013
Brugia malayi dehydrogenases, short chain protein 2 0.0011 0.002 0.0019
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0658 0.1079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.0658
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.023 0.0517
Brugia malayi hypothetical protein 0.006 0.0768 0.1263
Onchocerca volvulus 0.007 0.092 0.1327
Schistosoma mansoni hypothetical protein 0.0027 0.0265 0.0257
Leishmania major DNA polymerase eta, putative 0.0033 0.0356 0.0811
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.1259 0.1252
Brugia malayi CHD4 protein 0.0013 0.0051 0.0072
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Brugia malayi dehydrogenases, short chain protein 9 0.0011 0.002 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0011 0.002 0.0012
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0027 0.0107
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0747 0.3374
Schistosoma mansoni hypothetical protein 0.0033 0.0361 0.0353
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.009 0.0191
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0724 0.0716
Brugia malayi hypothetical protein 0.0011 0.002 0.0019
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.002 0.0053
Echinococcus granulosus dnaJ subfamily B 0.0395 0.587 0.5867
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0146 0.2084 0.345
Giardia lamblia Reductase, putative 0.0011 0.002 0.0137
Leishmania major GTP-binding protein, putative 0.0021 0.0172 0.0381
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0172 0.0163
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.002 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0752 0.0745
Toxoplasma gondii aldehyde dehydrogenase 0.0118 0.1656 0.6499
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0345 0.049
Leishmania major short chain dehydrogenase/reductase, putative 0.0011 0.002 0.0027
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.035 0.0497
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.1259 0.2915
Brugia malayi hypothetical protein 0.0011 0.0027 0.0032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0452 0.0444
Brugia malayi Dehydrogenases, short chain protein 2 0.0011 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0051 0.0643 0.1055
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0233 0.3407 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0345 0.1324
Mycobacterium ulcerans hypothetical protein 0.0154 0.2197 1
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.3051 0.8952
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0255 0.1001
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0747 0.0739
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0255 0.1001
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1457 0.8037
Mycobacterium tuberculosis Possible oxidoreductase 0.0011 0.002 0.0034
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.1457 0.4262
Brugia malayi oxidoreductase 0.0011 0.002 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.023 0.0873
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0011 0.002 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0021 0.0022
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0027 0.0075
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0345 0.7532
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Loa Loa (eye worm) pyruvate kinase 0.0032 0.035 0.0568
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0027 0.0107
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0724 0.0716
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Schistosoma mansoni DNA helicase recq1 0.0018 0.0135 0.0127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0027 0.0028
Echinococcus granulosus steroid dehydrogenase 0.0011 0.002 0.0012
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0172 0.0381
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.009 0.0082
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0245 0.0237
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0445 0.172
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0345 0.0559
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0014 0.0013
Toxoplasma gondii oxidoreductase, putative 0.0011 0.002 0.0078
Echinococcus granulosus hypothetical protein 0.0011 0.002 0.0012
Onchocerca volvulus 0.002 0.0168 0.0233
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.035 0.0497
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.002 0.0109
Echinococcus granulosus muscleblind protein 0.0146 0.2084 0.2078
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0011 0.002 0.0027
Echinococcus multilocularis snurportin 1 0.0297 0.4383 0.4378
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0526 0.0754
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4298 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0017 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0405 0.0924
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0172 0.0272
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0017 0.0009
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2084 0.2078
Trypanosoma brucei pyruvate kinase 1 0.0032 0.035 0.0797
Echinococcus granulosus cpg binding protein 0.0029 0.0306 0.0298
Onchocerca volvulus 0.0126 0.177 0.2564
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0453 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0768 0.1107
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0345 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0724 0.0716
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0386 0.0378
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0136
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0305 0.1197
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0083
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0092 0.0083
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0011 0.002 0.0034
Trypanosoma cruzi short chain dehydrogenase, putative 0.0011 0.002 0.0027
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0291 0.1143
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0014 0.0054
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0027 0.0075
Mycobacterium tuberculosis Probable reductase 0.021 0.3051 0.8952
Loa Loa (eye worm) hypothetical protein 0.0048 0.0592 0.097
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0337
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0011 0.002 0.0027
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0265 0.0427
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0748 0.074
Echinococcus granulosus transcription factor Dp 1 0.0074 0.099 0.0983
Plasmodium falciparum thioredoxin reductase 0.0032 0.0345 0.1324
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0255 0.041
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0345 0.0784
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0123 0.0167
Brugia malayi intermediate filament protein 0.0052 0.0658 0.1079
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0216 0.0484
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Loa Loa (eye worm) hypothetical protein 0.0026 0.0255 0.041
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0051 0.0043
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0011 0.002 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Plasmodium vivax glutathione reductase, putative 0.0092 0.1259 0.4923
Brugia malayi Fibulin-1 precursor 0.0016 0.0105 0.0161
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.023 0.0873
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0011 0.002 0.0137
Brugia malayi chromobox protein homolog 3 0.0038 0.0434 0.0707
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Loa Loa (eye worm) hypothetical protein 0.0038 0.0434 0.0707
Trypanosoma brucei calpain, putative 0.011 0.1526 0.3539
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0884 0.1454
Trypanosoma brucei pteridine reductase 1 0.0227 0.3314 0.7707
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.035 0.0568
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.035 0.0797
Onchocerca volvulus 0.0011 0.002 0.0017
Brugia malayi hypothetical protein 0.0035 0.0388 0.0632
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0361 0.0586
Plasmodium falciparum DNA repair protein REV1, putative 0.001 0.0014 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0135 0.0211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Onchocerca volvulus 0.0011 0.002 0.0017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0028
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trypanosoma cruzi metacaspase, putative 0.0026 0.0255 0.0575
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0711 0.0703
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0027 0.0019
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1457 0.2109
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0345 0.1324
Plasmodium falciparum importin beta, putative 0.0028 0.0284 0.1083
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0123 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Schistosoma mansoni phd/f-box containing protein 0.0015 0.009 0.0082
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0287 0.0464
Echinococcus granulosus Chromobox protein 3 0.0011 0.0027 0.0019
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.002 0.0012
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.002 0.0012
Echinococcus multilocularis steroid dehydrogenase 0.0011 0.002 0.0012
Trypanosoma brucei oxidoreductase-like protein 0.002 0.0168 0.0373
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Echinococcus multilocularis caspase 2 0.0026 0.0255 0.0247
Schistosoma mansoni chromobox protein 0.0067 0.0884 0.0876
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.023 0.0903
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0136
Schistosoma mansoni pyruvate kinase 0.0032 0.035 0.0342
Echinococcus multilocularis caspase 8 0.0026 0.0255 0.0247
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1073 0.5921
Echinococcus multilocularis protein quaking 0.0027 0.0265 0.0257
Loa Loa (eye worm) hypothetical protein 0.0025 0.0245 0.0393
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0592 0.097
Echinococcus granulosus carbonyl reductase 1 0.0011 0.002 0.0012
Brugia malayi Pre-SET motif family protein 0.0405 0.6027 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0291 0.1114
Giardia lamblia Pyruvate kinase 0.0032 0.035 0.7654
Plasmodium falciparum glutathione reductase 0.0092 0.1259 0.4923
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0011 0.002 0.0109
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0011 0.002 0.0027
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0011 0.002 0.0012
Brugia malayi Dehydrogenases, short chain protein 30 0.0011 0.002 0.0019
Leishmania major hypothetical protein, conserved 0.0024 0.023 0.0517
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0079 0.0102
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Echinococcus granulosus intermediate filament protein 0.0052 0.0658 0.065
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0011 0.002 0.0053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Leishmania major short chain dehydrogenase, putative 0.0011 0.002 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0752 0.0745
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0027 0.0019
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0526 0.0754
Echinococcus granulosus Tolloid protein 1 0.0016 0.0105 0.0097
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0011 0.002 0.0027
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0011 0.002 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1656 0.7528
Echinococcus granulosus chromobox protein 1 0.0067 0.0884 0.0876
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1457 0.2109
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0356 0.0348
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0051 0.0043
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0203 0.0455
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0233 0.3407 1
Plasmodium vivax steroid dehydrogenase, putative 0.0011 0.002 0.0045
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0026 0.0018
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0118 0.1656 0.4849
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0118 0.1656 0.3842
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0477 0.0683
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0284 0.1112
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.009 0.0136
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.2143
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0027 0.0028
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.1457 0.145
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0051 0.0639 0.2879
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Schistosoma mansoni pyruvate kinase 0.0032 0.035 0.0342
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Onchocerca volvulus 0.0011 0.002 0.0017

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1100 nM Inhibition of human factor 10a ChEMBL. 17933529
Ki (binding) = 1100 nM Inhibition of human factor 10a ChEMBL. 17933529

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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