Detailed information for compound 500455

Basic information

Technical information
  • TDR Targets ID: 500455
  • Name: 1-(3-amino-1,2-benzoxazol-5-yl)-5-[6-(2-oxoaz epan-1-yl)-2,3-dihydroindole-1-carbonyl]pyraz ole-3-carboxamide
  • MW: 499.521 | Formula: C26H25N7O4
  • H donors: 2 H acceptors: 5 LogP: 2.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)c1cc(n(n1)c1ccc2c(c1)c(N)no2)C(=O)N1CCc2c1cc(cc2)N1CCCCCC1=O
  • InChi: 1S/C26H25N7O4/c27-24-18-12-17(7-8-22(18)37-30-24)33-21(14-19(29-33)25(28)35)26(36)32-11-9-15-5-6-16(13-20(15)32)31-10-3-1-2-4-23(31)34/h5-8,12-14H,1-4,9-11H2,(H2,27,30)(H2,28,35)
  • InChiKey: DBTTUHJNJGMINA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-amino-1,2-benzoxazol-5-yl)-5-[6-(2-oxoazepan-1-yl)indoline-1-carbonyl]pyrazole-3-carboxamide
  • 1-(3-amino-1,2-benzoxazol-5-yl)-5-[oxo-[6-(2-oxo-1-azepanyl)-1-indolinyl]methyl]-3-pyrazolecarboxamide
  • 1-(3-azanyl-1,2-benzoxazol-5-yl)-5-[[6-(2-oxoazepan-1-yl)-2,3-dihydroindol-1-yl]carbonyl]pyrazole-3-carboxamide
  • 1-(3-aminoindoxazen-5-yl)-5-[6-(2-ketoazepan-1-yl)indoline-1-carbonyl]pyrazole-3-carboxamide
  • 1-(3-amino-1,2-benzoxazol-5-yl)-5-[6-(2-oxoazepan-1-yl)2,3-dihydroindole-1-carbonyl]pyrazole-3-carboxamide
  • 1-(3-amino-1,2-benzoxazol-5-yl)-5-[[6-(2-oxoazepan-1-yl)-2,3-dihydroindol-1-yl]carbonyl]pyrazole-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum metacaspase 1 0.0026 0.0255 0.0971
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0284 0.1112
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.021 0.3051 0.8952
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0011 0.002 0.0027
Echinococcus multilocularis lamin 0.0052 0.0658 0.065
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0105 0.0161
Brugia malayi Protein cec-1. 0.0011 0.0027 0.0032
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0051 0.0639 0.1854
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0402 0.0394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0752 0.0745
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Brugia malayi 6-phosphofructokinase 0.0105 0.1457 0.2407
Plasmodium falciparum pyruvate kinase 0.0032 0.035 0.1345
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0345 0.1536
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0592 0.097
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0526 0.0518
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0711 0.0703
Entamoeba histolytica short chain dehydrogenase family protein 0.0011 0.002 0.0109
Echinococcus multilocularis chromobox protein 1 0.0067 0.0884 0.0876
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.1457 0.3377
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0135 0.0127
Trypanosoma brucei calpain, putative 0.011 0.1526 0.3539
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0337
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Trypanosoma brucei unspecified product 0.0023 0.0202 0.0452
Toxoplasma gondii oxidoreductase, putative 0.0011 0.002 0.0078
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1656 0.7528
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1656 0.7528
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0477 0.0683
Schistosoma mansoni chromobox protein 0.0011 0.0027 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.035 0.0497
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.023 0.0873
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0026 0.0018
Trichomonas vaginalis set domain proteins, putative 0.0461 0.6877 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0345 0.1324
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0023 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Trypanosoma cruzi metacaspase, putative 0.0026 0.0255 0.0575
Trypanosoma brucei hypothetical protein 0.011 0.1526 0.3539
Loa Loa (eye worm) hypothetical protein 0.0031 0.033 0.0535
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0092 0.0083
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0233 0.3407 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0255 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0011 0.002 0.0034
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0011 0.002 0.0027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0011 0.002 0.0012
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0027
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.009 0.0323
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0291 0.0412
Echinococcus granulosus oxidoreductase 0.0011 0.002 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0203 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0014 0.0013
Onchocerca volvulus 0.0011 0.002 0.0017
Echinococcus granulosus steroid dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0128 0.1813 0.2998
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Entamoeba histolytica ubiquitin like protein 0.003 0.0311 0.1713
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0724 0.0716
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Echinococcus granulosus caspase 8 0.0026 0.0255 0.0247
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0386 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.1603 0.3717
Plasmodium falciparum thioredoxin reductase 0.0032 0.0345 0.1324
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Trypanosoma brucei calpain-like protein, putative 0.011 0.1526 0.3539
Echinococcus multilocularis GPCR, family 2 0.0015 0.0092 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0018 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Schistosoma mansoni cpg binding protein 0.0029 0.0306 0.0298
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.0311 0.0503
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1457 0.8037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0123 0.0167
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0014 0.0013
Plasmodium vivax importin-beta 2, putative 0.0028 0.0284 0.1083
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.002 0.0109
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0083
Onchocerca volvulus 0.0011 0.0027 0.0028
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0027 0.0032
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.3051 0.8952
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0748 0.074
Echinococcus granulosus muscleblind protein 0.0146 0.2084 0.2078
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0011 0.002 0.0019
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0526 0.0861
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.002 0.0168 0.0731
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0028
Brugia malayi jmjC domain containing protein 0.0057 0.0724 0.1189
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.1259 0.1252
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Leishmania major pyruvate kinase 0.0032 0.035 0.0797
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0118 0.1656 0.1649
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0118 0.1656 0.4849
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0291 0.1143
Schistosoma mansoni hypothetical protein 0.0395 0.587 0.5867
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Echinococcus granulosus caspase 3 0.0071 0.0943 0.0935
Brugia malayi Thioredoxin reductase 0.0092 0.1259 0.2078
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.009 0.0191
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0255 0.0575
Schistosoma mansoni cpg binding protein 0.0028 0.0282 0.0274
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.0311 0.0303
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.1603 0.1596
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0748 0.074
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0011 0.002 0.0045
Mycobacterium tuberculosis Hypothetical protein 0.006 0.0768 0.2236
Echinococcus granulosus carbonyl reductase 1 0.0011 0.002 0.0012
Schistosoma mansoni DNA helicase recq1 0.0018 0.0135 0.0127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0015
Echinococcus granulosus caspase 2 0.0026 0.0255 0.0247
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0356 0.0348
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0017 0.0009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Loa Loa (eye worm) pyruvate kinase 0.0032 0.035 0.0568
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0345 0.1324
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0345 0.0784
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0356 0.0811
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.1603 0.1596
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.002 0.0053
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0027 0.0075
Echinococcus granulosus hypothetical protein 0.0027 0.0265 0.0257
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0345 1
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Brugia malayi glutathione reductase 0.0092 0.1259 0.2078
Brugia malayi phosphofructokinase 0.0105 0.1457 0.2407
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Echinococcus multilocularis caspase 8 0.0026 0.0255 0.0247
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0128 0.1813 0.1806
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.002 0.0109
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0011 0.002 0.0027
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0284 0.0275
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.035 0.0497
Onchocerca volvulus 0.0052 0.0658 0.0945
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0345 0.0784
Mycobacterium ulcerans ketoacyl reductase 0.0011 0.002 0.0053
Schistosoma mansoni hypothetical protein 0.0297 0.4383 0.4378
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0216 0.0345
Onchocerca volvulus Arrow homolog 0.0016 0.0105 0.0141
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.4298 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0172 0.0163
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.002 0.0109
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0017 0.0009
Loa Loa (eye worm) thymidylate synthase 0.0126 0.177 0.2927
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0027 0.0028
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.002 0.0109
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0051 0.0639 0.1854
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.0103
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.0103
Mycobacterium ulcerans short-chain type oxidoreductase 0.0011 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0356 0.1023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.1603 0.265
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Brugia malayi CHD4 protein 0.0013 0.0051 0.0072
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0011 0.002 0.0137
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.062 0.1427
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.023 0.0517
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.035 0.0568
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0172 0.0163
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.1457 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.009 0.0136
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0051 0.0043
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.1457 0.3377
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0245 0.0237
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.196 0.455
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0092 0.0139
Onchocerca volvulus 0.0011 0.0027 0.0028
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0011 0.002 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.035 0.0568
Schistosoma mansoni pyruvate kinase 0.0032 0.035 0.0342
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0126 0.177 0.1763
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Loa Loa (eye worm) dehydrogenase 0.0011 0.002 0.0019
Leishmania major DNA polymerase kappa, putative 0.001 0.0014 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0011 0.002 0.0027
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Entamoeba histolytica hypothetical protein 0.0011 0.0027 0.0151
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0291 0.1114
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.035 0.1005
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0027 0.0019
Schistosoma mansoni ran 0.0021 0.0172 0.0163
Schistosoma mansoni hypothetical protein 0.0011 0.0026 0.0018
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0011 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.021
Echinococcus granulosus GPCR family 2 0.0015 0.0092 0.0083
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0011 0.002 0.0034
Brugia malayi hypothetical protein 0.0024 0.023 0.0369
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Brugia malayi Retinol dehydrogenase 12 0.0011 0.002 0.0019
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.0311 0.1219
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Mycobacterium ulcerans hypothetical protein 0.001 0.0014 0.0025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0233 0.3407 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0136
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0017 0.0014
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0291 0.1114
Onchocerca volvulus 0.0011 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0369
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.035 0.0497
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0337
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0282 0.0454
Giardia lamblia Hypothetical protein 0.0011 0.002 0.0137
Leishmania major metacaspase, putative 0.0026 0.0255 0.0575
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.1603 0.7284
Brugia malayi jmjC domain containing protein 0.0058 0.0748 0.1229
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.002 0.0012
Brugia malayi jmjC domain containing protein 0.0015 0.009 0.0136
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0027 0.0107
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0345 0.049
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0126 0.177 0.5182
Loa Loa (eye worm) hypothetical protein 0.0146 0.2084 0.345
Brugia malayi jmjC domain containing protein 0.0015 0.009 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.4298 1
Toxoplasma gondii oxidoreductase, putative 0.0011 0.002 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0747 0.1722
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.0311 0.0303
Echinococcus multilocularis protein quaking 0.0027 0.0265 0.0257
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0014 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0135 0.0127
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0255 0.0247
Entamoeba histolytica hypothetical protein 0.0023 0.0203 0.1122
Onchocerca volvulus 0.0011 0.002 0.0017
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0748 0.1229
Echinococcus granulosus WW domain containing oxidoreductase 0.0011 0.002 0.0012
Plasmodium vivax steroid dehydrogenase, putative 0.0011 0.002 0.0045
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.1457 0.2407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0284 0.0457
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0105 0.0413
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0079 0.0102
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0345 0.7532
Trypanosoma cruzi short chain dehydrogenase, putative 0.0011 0.002 0.0027
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0172 0.0643
Loa Loa (eye worm) hypothetical protein 0.0051 0.0643 0.1055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0752 0.0745
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0011 0.002 0.0053
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0011 0.002 0.0027
Echinococcus granulosus chromobox protein 1 0.0067 0.0884 0.0876
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0017 0.0009
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0027 0.0032
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0014 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Echinococcus multilocularis dihydrofolate reductase 0.0051 0.0639 0.0631
Loa Loa (eye worm) hypothetical protein 0.0015 0.009 0.0136
Leishmania major short chain dehydrogenase/reductase, putative 0.0011 0.002 0.0027
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0402 0.0394
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.035 0.0797
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0345 0.0784
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1656 0.7528
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 0.5922
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.1457 0.145
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.2143
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0027 0.0019
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.006 0.0768 0.1772
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.092 0.0912
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0752 0.0745
Onchocerca volvulus 0.0011 0.002 0.0017
Onchocerca volvulus 0.001 0.0018 0.0013
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0051 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0027 0.0028
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.001 0.0008 0.0033
Brugia malayi hypothetical protein 0.0016 0.0099 0.0151
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.3051 0.8952
Giardia lamblia Reductase, putative 0.0011 0.002 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Echinococcus multilocularis caspase 0.0097 0.1338 0.1331
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0011 0.002 0.0034
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0356 0.0348
Schistosoma mansoni carbonyl reductase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0434 0.0707
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0361 0.0585
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0011 0.002 0.0027
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.1457 0.4262
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.1591 0.263
Echinococcus granulosus retinol dehydrogenase 11 0.0011 0.002 0.0012
Entamoeba histolytica short chain dehydrogenase family protein 0.0011 0.002 0.0109
Brugia malayi oxidoreductase 0.0011 0.002 0.0019
Echinococcus multilocularis steroid dehydrogenase 0.0011 0.002 0.0012
Toxoplasma gondii thioredoxin reductase 0.0092 0.1259 0.4939
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Trypanosoma brucei trypanothione reductase 0.0092 0.1259 0.2915
Echinococcus multilocularis chromobox protein 1 0.0067 0.0884 0.0876
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0284 0.0642
Echinococcus granulosus phd:f box containing protein 0.0015 0.009 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0092 0.0083
Loa Loa (eye worm) pyruvate kinase 0.0032 0.035 0.0568
Schistosoma mansoni hypothetical protein 0.0164 0.235 0.2343
Plasmodium falciparum glutathione reductase 0.0092 0.1259 0.4923
Echinococcus granulosus dihydrofolate reductase 0.0051 0.0639 0.0631
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0284 0.0642
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.009 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Giardia lamblia Short-chain dehydrogenase, putative 0.0011 0.002 0.0137
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.0311 0.0303
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Mycobacterium ulcerans dehydrogenase/reductase 0.0011 0.002 0.0053
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0345 0.049
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.023 0.0903
Onchocerca volvulus 0.0461 0.6877 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0014
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2084 0.2078
Leishmania major short chain dehydrogenase, putative 0.0011 0.002 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.023 0.0873
Echinococcus granulosus chromobox protein 2 0.0011 0.0027 0.0019
Echinococcus multilocularis retinol dehydrogenase 13 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.009 0.0082
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0477 0.0683
Onchocerca volvulus 0.007 0.092 0.1327
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0245 0.0237
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0345 0.0784
Mycobacterium ulcerans ketoacyl reductase 0.0011 0.002 0.0053
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0135 0.021
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0255 0.0971
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.0311 0.119
Plasmodium falciparum steroid dehydrogenase, putative 0.0011 0.002 0.0045
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0026 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Schistosoma mansoni chromobox protein 0.0011 0.0027 0.0019
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0128 0.1813 0.4207
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0172 0.0272
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Echinococcus multilocularis oxidoreductase 0.0011 0.002 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0123 0.0167
Leishmania major dehydrogenase-like protein 0.0011 0.002 0.0027
Brugia malayi Pre-SET motif family protein 0.0059 0.0752 0.1236
Plasmodium falciparum glutathione reductase 0.0032 0.0345 0.1324
Echinococcus multilocularis musashi 0.0052 0.0658 0.065
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0027 0.0019
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0216 0.0484
Echinococcus multilocularis pyruvate kinase 0.0032 0.035 0.0342
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0011 0.002 0.0109
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0011 0.002 0.0027
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0027 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0484 0.1109
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0311 0.044
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.0103
Echinococcus granulosus lamin 0.0052 0.0658 0.065
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0027
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0027
Echinococcus granulosus lamin dm0 0.0052 0.0658 0.065
Echinococcus multilocularis laminin 0.0016 0.0105 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0405 0.0924
Trypanosoma brucei unspecified product 0.0052 0.065 0.1496
Schistosoma mansoni hypothetical protein 0.0011 0.0027 0.0019
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0011 0.002 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0135 0.0498
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0014 0.0054
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Mycobacterium ulcerans oxidoreductase 0.0011 0.002 0.0053
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Echinococcus multilocularis chromobox protein 2 0.0011 0.0027 0.0019
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0291 0.1143
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.1457 0.6618
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0747 0.0739
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) pyruvate kinase 0.0032 0.035 0.0568
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0172 0.0643
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.2143
Echinococcus multilocularis geminin 0.0164 0.235 0.2343
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0105 0.0413
Brugia malayi Pre-SET motif family protein 0.0405 0.6027 1
Brugia malayi hypothetical protein 0.0011 0.0027 0.0032
Brugia malayi hypothetical protein 0.001 0.0018 0.0016
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0135 0.0127
Plasmodium vivax metacaspase 1, putative 0.0026 0.0255 0.0971
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0011 0.002 0.0034
Loa Loa (eye worm) RecQ helicase 0.0044 0.0526 0.086
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0452 0.0444
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0203 0.0455
Echinococcus multilocularis phd:f box containing protein 0.0015 0.009 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0168 0.0471
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.009 0.0191
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.1813 0.4207
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0345 0.1324
Trypanosoma brucei unspecified product 0.0023 0.0202 0.0452
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0345 0.0559
Brugia malayi Importin beta-1 subunit 0.0028 0.0284 0.0458
Trypanosoma brucei pteridine reductase 1 0.0227 0.3314 0.7707
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0138
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0747 0.3374
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0151
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0216 0.0484
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0092 0.0139
Plasmodium vivax glutathione reductase, putative 0.0092 0.1259 0.4923
Echinococcus multilocularis Chromo domain 0.0011 0.0027 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0011 0.002 0.0034
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0011 0.002 0.0034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Onchocerca volvulus 0.0011 0.002 0.0017
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Echinococcus granulosus caspase 0.0097 0.1338 0.1331
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Echinococcus multilocularis conserved hypothetical protein 0.0011 0.002 0.0012
Plasmodium falciparum importin beta, putative 0.0028 0.0284 0.1083
Mycobacterium ulcerans oxidoreductase 0.0011 0.002 0.0053
Loa Loa (eye worm) helicase 0.0011 0.0027 0.0032
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0255 0.041
Plasmodium falciparum DNA repair protein REV1, putative 0.001 0.0014 0.0022
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0011 0.002 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0151
Mycobacterium leprae Probable oxidoreductase 0.0011 0.002 0.0034
Mycobacterium ulcerans hypothetical protein 0.0154 0.2197 1
Brugia malayi intermediate filament protein 0.0052 0.0658 0.1079
Toxoplasma gondii aldehyde dehydrogenase 0.0118 0.1656 0.6499
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Brugia malayi Muscleblind-like protein 0.0146 0.2084 0.345
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0453 0.1308
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0266 0.0375
Schistosoma mansoni hypothetical protein 0.0033 0.0361 0.0353
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.1259 0.2078
Leishmania major importin beta-1 subunit, putative 0.0023 0.0203 0.0455
Echinococcus granulosus dnaJ subfamily B 0.0395 0.587 0.5867
Brugia malayi jmjC domain containing protein 0.0015 0.009 0.0136
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Schistosoma mansoni cpg binding protein 0.0029 0.0306 0.0298
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0752 0.2952
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0361 0.0586
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0014 0.0013
Echinococcus granulosus intermediate filament protein 0.0052 0.0658 0.065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0784
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.1338 0.1331
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0305 0.1197
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.002 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.011 0.1526 0.3539
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0172 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Onchocerca volvulus 0.0011 0.002 0.0017
Trypanosoma brucei metacaspase MCA3 0.0026 0.0255 0.0575
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.2143
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Schistosoma mansoni DNA helicase recq5 0.0018 0.0135 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.009 0.0136
Schistosoma mansoni hypothetical protein 0.0027 0.0265 0.0257
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.001 0.0008 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0027 0.0028
Echinococcus granulosus pyruvate kinase 0.0032 0.035 0.0342
Echinococcus granulosus protein quaking 0.0027 0.0265 0.0257
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0027 0.0032
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0168 0.0731
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0011 0.002 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0724 0.0716
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.1813 0.4207
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0011 0.002 0.0078
Plasmodium vivax DNA repair protein REV1, putative 0.001 0.0014 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0255 0.1001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0752 0.0745
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0027 0.0028
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.0311 0.119
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0388 0.038
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Echinococcus multilocularis lamin dm0 0.0052 0.0658 0.065
Echinococcus multilocularis fibrillin 1 0.0016 0.0105 0.0097
Brugia malayi hypothetical protein 0.0035 0.0388 0.0632
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0105 0.0161
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.1457 0.145
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Echinococcus granulosus carbonyl reductase 1 0.0011 0.002 0.0012
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0011 0.002 0.0019
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0011 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.0658
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0097 0.1338 0.1331
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Schistosoma mansoni DNA polymerase eta 0.0033 0.0356 0.0348
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0366 0.0521
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Brugia malayi dihydrofolate reductase family protein 0.0051 0.0639 0.1048
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0168 0.0731
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0311 0.0705
Schistosoma mansoni microtubule-associated protein tau 0.0667 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Onchocerca volvulus 0.0052 0.0658 0.0945
Loa Loa (eye worm) hypothetical protein 0.0022 0.0202 0.0321
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.3051 0.8952
Trypanosoma brucei metacaspase MCA2 0.0026 0.0255 0.0575
Trypanosoma cruzi metacaspase, putative 0.0026 0.0255 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0768 0.1107
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 0.5922
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0266 0.0375
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0083
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0203 0.0284
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Echinococcus granulosus importin subunit beta 1 0.0028 0.0284 0.0275
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0126 0.177 0.5182
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0345 0.1536
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.1457 0.145
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.009 0.0354
Schistosoma mansoni pyruvate kinase 0.0017 0.0111 0.0103
Loa Loa (eye worm) hypothetical protein 0.003 0.031 0.0501
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0724 0.0716
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0011 0.002 0.0012
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0128 0.1813 1
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1457 0.2109
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0051 0.0043
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.002 0.0012
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0402 0.0654
Brugia malayi hypothetical protein 0.006 0.0768 0.1263
Loa Loa (eye worm) dehydrogenase 0.0011 0.002 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0884 0.1274
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0255 0.1001
Echinococcus granulosus chromobox protein 1 0.0067 0.0884 0.0876
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0255 0.1001
Trichomonas vaginalis hypothetical protein 0.0011 0.0027 0.0028
Loa Loa (eye worm) tumor suppressor 0.0315 0.4649 0.7711
Brugia malayi Dehydrogenases, short chain protein 2 0.0011 0.002 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0118 0.1656 0.3842
Echinococcus granulosus transcription factor Dp 1 0.0074 0.099 0.0983
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0011 0.002 0.0034
Trypanosoma cruzi metacaspase, putative 0.0026 0.0255 0.0575
Loa Loa (eye worm) hypothetical protein 0.008 0.1073 0.177
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.196 0.455
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0747 0.1722
Onchocerca volvulus 0.0126 0.177 0.2564
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0405 0.6027 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0059 0.0752 0.1236
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.4383 0.7269
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Brugia malayi CXXC zinc finger family protein 0.0028 0.0282 0.0455
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Echinococcus multilocularis transcription factor Dp 1 0.0074 0.099 0.0983
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.1656 0.1649
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.009 0.0082
Chlamydia trachomatis pyruvate kinase 0.0032 0.035 0.5421
Onchocerca volvulus 0.0011 0.002 0.0017
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0356 0.0348
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0445 0.172
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0105 0.0161
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0011 0.002 0.0012
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.1259 0.4923
Brugia malayi thymidylate synthase 0.0126 0.177 0.2927
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2197 0.6441
Brugia malayi hypothetical protein 0.0011 0.002 0.0019
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0526 0.0754
Entamoeba histolytica hypothetical protein 0.0011 0.0027 0.0151
Trichomonas vaginalis ubiquitin, putative 0.001 0.0018 0.0013
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.1603 0.4691
Leishmania major quinonoid dihydropteridine reductase 0.0011 0.002 0.0027
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Toxoplasma gondii hypothetical protein 0.0047 0.0576 0.2258
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.1603 0.7284
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0356 0.0578
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0105 0.0161
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0658 0.1079
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0747 0.3374
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0011 0.002 0.0027
Loa Loa (eye worm) SMO-1 protein 0.003 0.0311 0.0502
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0356 0.0578
Mycobacterium ulcerans dehydrogenase 0.0011 0.002 0.0053
Brugia malayi Fibulin-1 precursor 0.0016 0.0105 0.0161
Schistosoma mansoni pyruvate kinase 0.0032 0.035 0.0342
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0011 0.002 0.0012
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0345 0.1324
Loa Loa (eye worm) hypothetical protein 0.0048 0.0592 0.097
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0135 0.0211
Echinococcus multilocularis caspase 2 0.0026 0.0255 0.0247
Brugia malayi SET domain containing protein 0.0014 0.0069 0.0101
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.009 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Brugia malayi hypothetical protein 0.0027 0.0265 0.0427
Brugia malayi 6-phosphofructokinase 0.0105 0.1457 0.2407
Mycobacterium tuberculosis Probable dehydrogenase 0.0011 0.002 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Echinococcus granulosus Chromo domain 0.0011 0.0027 0.0019
Schistosoma mansoni ran 0.0021 0.0172 0.0163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.023 0.0873
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0203 0.0284
Plasmodium vivax SET domain protein, putative 0.0059 0.0752 0.2929
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0747 0.1075
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0111 0.0406
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0345 0.1536
Brugia malayi hypothetical protein 0.0011 0.002 0.0019
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0105 0.0097
Schistosoma mansoni egf-like domain protein 0.0016 0.0105 0.0097
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0484 0.1109
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0434 0.0619
Echinococcus multilocularis muscleblind protein 0.0146 0.2084 0.2078
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0748 0.074
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0097 0.1338 0.1331
Echinococcus granulosus Tolloid protein 1 0.0016 0.0105 0.0097
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0011 0.002 0.0017
Echinococcus multilocularis snurportin 1 0.0297 0.4383 0.4378
Onchocerca volvulus 0.0028 0.0282 0.0398
Giardia lamblia Pyruvate kinase 0.0032 0.035 0.7654
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0453 0.1037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0164 0.235 0.2343
Schistosoma mansoni intermediate filament proteins 0.0052 0.0658 0.065
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0011 0.002 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0014 0.0013
Trypanosoma brucei Metacaspase-4 0.0026 0.0255 0.0575
Onchocerca volvulus 0.0011 0.002 0.0017
Trypanosoma cruzi short chain dehydrogenase, putative 0.0011 0.002 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0784
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0027 0.0019
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.1457 0.4262
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0172 0.0381
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0011 0.002 0.0017
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Echinococcus multilocularis thymidylate synthase 0.0126 0.177 0.1763
Loa Loa (eye worm) hypothetical protein 0.0025 0.0245 0.0393
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Leishmania major pyruvate kinase 0.0032 0.035 0.0797
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0011 0.002 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0388 0.038
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0216 0.119
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0027 0.0075
Schistosoma mansoni jumonji domain containing protein 0.0015 0.009 0.0082
Echinococcus granulosus dna polymerase kappa 0.0058 0.0747 0.0739
Leishmania major oxidoreductase-like protein 0.002 0.0168 0.0373
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0291 0.1143
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4298 1
Leishmania major trypanothione reductase 0.0092 0.1259 0.2915
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0291 0.6318
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0011 0.002 0.0027
Trichomonas vaginalis steroid dehydrogenase, putative 0.0011 0.002 0.0017
Mycobacterium ulcerans carveol-like dehydrogenase 0.0011 0.002 0.0053
Schistosoma mansoni chromobox protein 0.0067 0.0884 0.0876
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0105 0.0097
Echinococcus granulosus geminin 0.0164 0.235 0.2343
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.0311 0.0705
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1073 0.5921
Echinococcus multilocularis transient receptor potential cation channel 0.0011 0.002 0.0012
Echinococcus granulosus cpg binding protein 0.0029 0.0306 0.0298
Trypanosoma cruzi calpain cysteine peptidase, putative 0.011 0.1526 0.3539
Echinococcus granulosus carbonyl reductase 1 0.0011 0.002 0.0012
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0011 0.002 0.0034
Schistosoma mansoni protein phosphatase 2C 0.0015 0.009 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Brugia malayi Dehydrogenases, short chain protein 30 0.0011 0.002 0.0019
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0658 0.1079
Schistosoma mansoni carbonyl reductase 0.0011 0.002 0.0012
Schistosoma mansoni carbonyl reductase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0311 0.0705
Chlamydia trachomatis dihydrofolate reductase 0.0051 0.0639 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.009 0.0191
Leishmania major 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0027
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0356 0.0811
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Leishmania major GTP-binding protein, putative 0.0021 0.0172 0.0381
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0526 0.0754
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.002 0.0045
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0011 0.002 0.0017
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0724 0.0716
Echinococcus granulosus hypothetical protein 0.0011 0.002 0.0012
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0027 0.0075
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0135 0.0529
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Trichomonas vaginalis ran, putative 0.0021 0.0172 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.1603 0.1596
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0452 0.0444
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0291 0.1114
Echinococcus granulosus hypothetical protein 0.0011 0.002 0.0012
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0291 0.1114
Brugia malayi polk-prov protein 0.0036 0.0405 0.0659
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.1656 0.1649
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1457 0.2109
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0884 0.1454
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0011 0.002 0.0109
Entamoeba histolytica Ran family GTPase 0.0021 0.0172 0.0947
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0011 0.002 0.0078
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0216 0.0302
Brugia malayi tumor suppressor. 0.0315 0.4649 0.7711
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.031 0.1189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Leishmania major hypothetical protein, conserved 0.0015 0.009 0.0191
Brugia malayi chromobox protein homolog 3 0.0038 0.0434 0.0707
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0752 0.0745
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0014 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0405 0.0924
Plasmodium vivax JmjC domain containing protein 0.0015 0.009 0.0323
Echinococcus multilocularis pyruvate kinase 0.0025 0.0247 0.0239
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0011 0.002 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Entamoeba histolytica pyruvate kinase, putative 0.0022 0.0202 0.1112
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0011 0.002 0.0027
Leishmania major DNA polymerase eta, putative 0.0033 0.0356 0.0811
Leishmania major small ubiquitin protein, putative 0.003 0.0311 0.0705
Schistosoma mansoni lamin 0.0052 0.0658 0.065
Schistosoma mansoni DNA polymerase IV / kappa 0.001 0.0014 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Leishmania major hypothetical protein, conserved 0.0024 0.023 0.0517
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.1457 0.145
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.009 0.0082
Giardia lamblia Sentrin 0.003 0.0311 0.6757
Schistosoma mansoni hypothetical protein 0.0035 0.0388 0.038
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Mycobacterium ulcerans thymidylate synthase 0.0126 0.177 0.8047
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0011 0.002 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0299 0.0678
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.023 0.0517
Echinococcus multilocularis microtubule associated protein 2 0.0667 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0168 0.0373
Toxoplasma gondii carbonyl reductase 1, putative 0.0011 0.002 0.0078
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0118 0.1656 0.1649
Leishmania major DNA polymerase eta, putative 0.001 0.0014 0.0013
Trypanosoma brucei pyruvate kinase 1 0.0032 0.035 0.0797
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0011 0.002 0.0017
Leishmania major pteridine reductase 1 0.0238 0.3474 0.808
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0092 0.0083
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0016 0.0111 0.0435
Echinococcus multilocularis pyruvate kinase 0.0032 0.035 0.0342
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0172 0.0673
Loa Loa (eye worm) phosphofructokinase 0.0105 0.1457 0.2407
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0011 0.002 0.0034
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.001 0.0008 0.0033
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0434 0.0619
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Schistosoma mansoni retinal dehydrogenase 0.0011 0.002 0.0012
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0255 0.041
Onchocerca volvulus Sepiapterin reductase homolog 0.0011 0.002 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4298 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0291 0.449
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0356 0.0578
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.2143
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0255 0.0359
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0027 0.0107
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0291 0.1607
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0128 0.1813 0.1806
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0051 0.0072
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0453 0.1037
Loa Loa (eye worm) hypothetical protein 0.0052 0.0658 0.1079
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1457 0.8037
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 1
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.009 0.0082
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.002 0.0168 0.0661
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1457 0.2109
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.3051 0.8952
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0028
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.035 0.0797
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.002 0.0053
Leishmania major DNA polymerase kappa, putative 0.0039 0.0453 0.1037
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0027 0.0151
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.1457 0.2407
Echinococcus granulosus pyruvate kinase 0.0032 0.035 0.0342
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0787 0.078
Echinococcus granulosus thymidylate synthase 0.0126 0.177 0.1763
Schistosoma mansoni importin beta-1 0.0028 0.0284 0.0275
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0287 0.0463
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0135 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.035 0.0497
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0011 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0015
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0011 0.002 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0299 0.0678
Entamoeba histolytica hypothetical protein 0.0011 0.0027 0.0151
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0658 0.1079
Onchocerca volvulus 0.0011 0.002 0.0017
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0692 0.2714
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.035 0.1005
Echinococcus multilocularis carbonyl reductase 1 0.0011 0.002 0.0012
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0135 0.2756
Echinococcus granulosus dna polymerase eta 0.0033 0.0356 0.0348
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0287 0.0464
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.002 0.0034
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0291 0.449
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0011 0.002 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0123 0.0167
Echinococcus multilocularis steroid dehydrogenase 0.0011 0.002 0.0012
Leishmania major short chain dehydrogenase-like protein 0.0011 0.002 0.0027
Echinococcus granulosus bloom syndrome protein 0.0044 0.0526 0.0518
Brugia malayi jmjC domain containing protein 0.0015 0.009 0.0136
Echinococcus granulosus Chromobox protein 3 0.0011 0.0027 0.0019
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0011 0.002 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0884 0.1274
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0427
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0592 0.0971
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0027 0.0107
Echinococcus multilocularis caspase 3 0.0071 0.0943 0.0935
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0255 0.0575
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0177 0.2549 0.5922
Treponema pallidum NADH oxidase 0.0032 0.0345 0.0457
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0255 0.0575
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0027
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0051 0.0639 0.2879
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0345 0.0784
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0111 0.0437
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.0103
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0072 0.0092
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0265 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0434 0.0619
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0011 0.002 0.0034
Mycobacterium tuberculosis Probable reductase 0.021 0.3051 0.8952
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0345 0.0337
Echinococcus granulosus laminin 0.0016 0.0105 0.0097
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0011 0.002 0.0053
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.009 0.0136
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0345 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.023 0.0517
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0027 0.0075
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0011 0.002 0.0012
Echinococcus granulosus carbonyl reductase 1 0.0011 0.002 0.0012
Onchocerca volvulus 0.002 0.0168 0.0233
Trypanosoma brucei short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.035 0.1373
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.196 0.455
Schistosoma mansoni dihydrofolate reductase 0.0051 0.0639 0.0631
Leishmania major short chain dehydrogenase/reductase, putative 0.0011 0.002 0.0027
Entamoeba histolytica hypothetical protein 0.001 0.0018 0.0097
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.587 0.5867
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0079 0.0102
Trypanosoma cruzi DNA polymerase eta, putative 0.001 0.0014 0.0013
Onchocerca volvulus 0.003 0.031 0.0439
Echinococcus granulosus ubiquitin 0.001 0.0018 0.0009
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0128 0.1813 0.1806
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0216 0.0484
Mycobacterium ulcerans pyruvate kinase 0.0032 0.035 0.1561
Trypanosoma cruzi metacaspase, putative 0.0026 0.0255 0.0575
Mycobacterium tuberculosis Probable oxidoreductase 0.0233 0.3407 1
Plasmodium falciparum metacaspase-like protein 0.0026 0.0255 0.0971
Brugia malayi Cell death protein 3 precursor 0.0026 0.0255 0.041
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.002 0.0053
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0345 0.0784
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0114 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0092 0.0138
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0021 0.0022
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.009 0.0082
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.1259 0.2915
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0255 0.041
Brugia malayi Heterochromatin protein 1 0.0067 0.0884 0.1455
Trypanosoma brucei oxidoreductase-like protein 0.002 0.0168 0.0373
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0135 0.0529
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0135 0.0211
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0011 0.002 0.0045
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.002 0.0034
Echinococcus multilocularis retinol dehydrogenase 11 0.0011 0.002 0.0012
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1073 0.5921
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0114 0.0106
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0366 0.0521
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0216 0.0345
Entamoeba histolytica hypothetical protein 0.0011 0.002 0.0109
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.1457 0.3377
Loa Loa (eye worm) hypothetical protein 0.0146 0.2084 0.345
Echinococcus granulosus voltage gated potassium channel 0.001 0.0017 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0027 0.0075
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1457 0.8037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Echinococcus multilocularis retinol dehydrogenase 11 0.0011 0.002 0.0012
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0011 0.002 0.0034
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0356 0.0348
Schistosoma mansoni steroid dehydrogenase 0.0011 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0019
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0345 0.0784
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.009 0.0354
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.035 0.0797
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.065 0.1496
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0345 0.1352
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0356 0.1964
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.0103
Schistosoma mansoni caspase-3 (C14 family) 0.0097 0.1338 0.1331
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Brugia malayi RNA, U transporter 1 0.0079 0.1065 0.1755
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.001 0.0008 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1457 0.2109
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0011 0.002 0.0012
Echinococcus granulosus retinol dehydrogenase 11 0.0011 0.002 0.0012
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0128 0.1813 0.2999
Loa Loa (eye worm) oxidoreductase 0.0011 0.002 0.0019
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.0202 0.0321
Giardia lamblia DINP protein human, muc B family 0.0039 0.0453 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0168 0.0731
Leishmania major short chain dehydrogenase, putative 0.0011 0.002 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0388 0.038
Mycobacterium tuberculosis Possible oxidoreductase 0.0011 0.002 0.0034
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0027 0.0075
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.1526 0.3539
Onchocerca volvulus 0.0011 0.002 0.0017
Mycobacterium ulcerans ketoacyl reductase 0.0011 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0133 0.1885 0.3119
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0172 0.0381
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.035 0.0568
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0017 0.0009
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0484 0.1109
Schistosoma mansoni hypothetical protein 0.0027 0.0265 0.0257
Schistosoma mansoni chromobox protein 0.0067 0.0884 0.0876
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.3051 0.8952
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0017 0.0009
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0078
Giardia lamblia Pyruvate kinase 0.0017 0.0111 0.2222
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0752 0.0745
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0011 0.002 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0747 0.1722
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0105 0.0161
Loa Loa (eye worm) hypothetical protein 0.0033 0.0356 0.0578
Brugia malayi dehydrogenases, short chain protein 9 0.0011 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0161
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.035 0.0497
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0027 0.0032
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0172 0.3593
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0345 0.1352
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0111 0.0406
Loa Loa (eye worm) dihydrofolate reductase 0.0051 0.0639 0.1047
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.009 0.0082
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0011 0.002 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0299 0.0678
Echinococcus multilocularis cpg binding protein 0.0029 0.0306 0.0298
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.1813 0.4207
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0032
Trypanosoma brucei metacaspase 0.0026 0.0255 0.0575
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0011 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0369
Onchocerca volvulus 0.0011 0.002 0.0017
Schistosoma mansoni lamin 0.0052 0.0658 0.065
Brugia malayi Dihydrofolate reductase 0.0051 0.0639 0.1048
Plasmodium vivax pyruvate kinase, putative 0.0032 0.035 0.1345
Mycobacterium ulcerans short-chain dehydrogenase 0.0011 0.002 0.0053
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0027 0.0028
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0083
Onchocerca volvulus 0.0011 0.002 0.0017
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0484 0.1109
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0011 0.002 0.0343
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0255 0.0359
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0345 0.0989
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.1259 0.1252
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0345 0.0784
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.011 0.1526 0.3539
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.1259 0.3679
Brugia malayi dehydrogenases, short chain protein 2 0.0011 0.002 0.0019
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0011 0.002 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0255 0.0359
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0233 0.3407 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0345 0.5335
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0747 0.1075
Loa Loa (eye worm) glutathione reductase 0.0092 0.1259 0.2078
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0592 0.0971
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0477 0.0683
Leishmania major DNA damage repair protein, putative 0.001 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0083
Echinococcus granulosus snurportin 1 0.0297 0.4383 0.4378
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0402 0.0654
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0291 0.0412
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0011 0.002 0.0012
Echinococcus multilocularis dna polymerase eta 0.0033 0.0356 0.0348
Schistosoma mansoni phd/f-box containing protein 0.0015 0.009 0.0082
Trypanosoma brucei chrX additional, unordered contigs 0.001 0.0014 0.0013
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0177 0.2549 1
Echinococcus multilocularis ubiquitin 0.001 0.0018 0.0009
Mycobacterium tuberculosis Possible oxidoreductase 0.0011 0.002 0.0034
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Schistosoma mansoni short chain dehydrogenase 0.0011 0.002 0.0012
Plasmodium falciparum thioredoxin reductase 0.0092 0.1259 0.4923
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0172 0.0381
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0092 0.0083
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.002 0.0053
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0011 0.002 0.0027

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1100 nM Inhibition of human factor 10a ChEMBL. 17933529
Ki (binding) = 1100 nM Inhibition of human factor 10a ChEMBL. 17933529

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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