Detailed information for compound 515070

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 363.45 | Formula: C23H25NO3
  • H donors: 0 H acceptors: 0 LogP: 4.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)ccc(c2)CN1CCc2c(C1)cc(c(c2)OC)OC
  • InChi: 1S/C23H25NO3/c1-25-21-7-6-17-10-16(4-5-18(17)11-21)14-24-9-8-19-12-22(26-2)23(27-3)13-20(19)15-24/h4-7,10-13H,8-9,14-15H2,1-3H3
  • InChiKey: KREIZVZORLBDNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sodium/chloride dependent transporter 0.0259 0.1555 0.1611
Loa Loa (eye worm) hypothetical protein 0.0253 0.152 0.1586
Brugia malayi hypoxia-induced factor 1 0.0163 0.0947 0.0973
Brugia malayi RNA binding protein 0.007 0.0359 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.039 0.1271
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0646 0.1368
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0031 0.0066
Loa Loa (eye worm) cytochrome P450 0.0023 0.0064 0.0061
Onchocerca volvulus 0.0253 0.152 0.1586
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.005 0.0235 0.0226
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1173 0.1167
Leishmania major cytochrome p450-like protein 0.0023 0.0064 0.0137
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0078 0.0414 0.0413
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.039 0.0389
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0269 0.0276
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Schistosoma mansoni glutamate receptor AMPA 0.0157 0.0909 0.0933
Schistosoma mansoni hypothetical protein 0.1054 0.6582 0.6882
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.0414 0.0408
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0021 0.0311
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0058 0.0286 0.028
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Schistosoma mansoni polycystin 1-related 0.0041 0.018 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.039 0.0827
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0058 0.0286 0.028
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0094 0.02
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0212 0.0202
Loa Loa (eye worm) LGC-31 protein 0.0108 0.0603 0.0626
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0108 0.0603 0.0626
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.005 0.0235 0.024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0023 0.0064 0.0411
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0016 0.0022 0.0016
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0108 0.0603 0.0598
Brugia malayi Melatonin receptor type 1A 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Echinococcus granulosus glycine receptor subunit beta 0.0108 0.0603 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0087
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Echinococcus multilocularis glutamate receptor 2 0.0157 0.0909 0.0903
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0185 0.0179
Onchocerca volvulus 0.0078 0.0414 0.0427
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.1011 0.1006
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus neuropeptide receptor A26 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0079 0.0422 0.1378
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.003 0.0064
Echinococcus granulosus synaptic vesicular amine transporter 0.0204 0.1207 0.1202
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.018 0.0175
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.0414 0.0413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.0414 0.0413
Echinococcus multilocularis glutamate receptor NMDA 0.0084 0.045 0.0444
Loa Loa (eye worm) hypothetical protein 0.0172 0.1005 0.1046
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0021 0.0244
Echinococcus granulosus nmda type glutamate receptor 0.0142 0.0816 0.081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0021 0.0044
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Echinococcus multilocularis Ankyrin 0.0016 0.002 0.0014
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0023 0.0064 0.0411
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0055 0.0269 0.0276
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.0064 0.015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0422 0.0416
Brugia malayi putative neuropeptide receptor 0.0078 0.0414 0.0413
Echinococcus granulosus atrial natriuretic peptide receptor 0.0016 0.0022 0.0016
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.0064 0.015
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.0414 0.0413
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0674 0.1427
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0414 0.0413
Leishmania major extracellular receptor, putative 0.0016 0.0022 0.0046
Echinococcus granulosus g-protein coupled receptor 0.0078 0.0414 0.0408
Echinococcus granulosus orexin receptor type 2 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.0064 0.015
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0123 0.0667
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0212 0.0216
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0123 0.0672
Schistosoma mansoni neuropeptide receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0422 0.0416
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Echinococcus multilocularis musashi 0.0055 0.0269 0.0263
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0023 0.0064 0.0411
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.0414 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Entamoeba histolytica hypothetical protein 0.0016 0.0022 0.0255
Loa Loa (eye worm) hypothetical protein 0.0203 0.1204 0.1255
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.0064 0.015
Onchocerca volvulus 0.1525 0.9555 1
Schistosoma mansoni opsin-like receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.1005 0.1033
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.003 0.0026
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0414 0.0427
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.007 0.1041
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0259 0.1555 1
Toxoplasma gondii exonuclease III APE 0.0079 0.0422 0.2615
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0023 0.0064 0.0411
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0058 0.0288 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0023 0.0064 0.0411
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Onchocerca volvulus 0.0078 0.0414 0.0427
Echinococcus granulosus lamin 0.0055 0.0269 0.0263
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0115 0.0646 0.7516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0476 0.293 0.3062
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0031 0.0012
Brugia malayi Cytochrome P450 family protein 0.0033 0.0125 0.0111
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus multilocularis geminin 0.1054 0.6582 0.658
Echinococcus multilocularis glycine receptor subunit beta 0.0108 0.0603 0.0598
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.039 0.1271
Echinococcus multilocularis glycine receptor subunit beta 0.0108 0.0603 0.0598
Echinococcus granulosus receptor type guanylyl cyclase 0.0016 0.0022 0.0016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.1011 0.1006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.0064 0.015
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Onchocerca volvulus 0.0253 0.152 0.1586
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0021 0.0311
Echinococcus granulosus intermediate filament protein 0.0055 0.0269 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Treponema pallidum sodium- and chloride- dependent transporter 0.1525 0.9555 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0333 0.2022 0.2017
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0123 0.1435
Schistosoma mansoni hypothetical protein 0.0078 0.0414 0.0413
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Schistosoma mansoni loxhd1 0.0041 0.018 0.0169
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Onchocerca volvulus 0.0259 0.1555 0.1623
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.039 0.1271
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0021 0.0044
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0108 0.0603 0.0598
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.018 0.0175
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0108 0.0603 0.0613
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0212 0.0206
Loa Loa (eye worm) MBCTL1 0.0053 0.0252 0.0258
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0414 0.0408
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Echinococcus multilocularis somatostatin receptor 0.0078 0.0414 0.0408
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.0144
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.0414 0.0427
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0108 0.0603 0.0598
Brugia malayi neuropeptide F receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0036 0.0145 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0094 0.02
Onchocerca volvulus 0.005 0.0235 0.024
Schistosoma mansoni intermediate filament proteins 0.0055 0.0269 0.0262
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0414 0.0408
Schistosoma mansoni neuropeptide receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1623
Loa Loa (eye worm) ACC-1 protein 0.0108 0.0603 0.0626
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0086
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0414 0.0427
Brugia malayi G-protein coupled receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0079 0.0422 0.0436
Mycobacterium ulcerans hypothetical protein 0.0075 0.039 0.4342
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0068 0.0162
Loa Loa (eye worm) acetylcholine receptor protein 0.005 0.0235 0.024
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0212 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.039 0.0389
Trypanosoma brucei C-8 sterol isomerase, putative 0.076 0.4722 1
Schistosoma mansoni hypothetical protein 0.0078 0.0414 0.0413
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.003 0.0025
Schistosoma mansoni rab6-interacting 0.0041 0.018 0.0169
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0165 0.1626
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0646 0.959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1525 0.9555 1
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.018 0.0168
Schistosoma mansoni sodium-dependent amino acid transporter 0.0259 0.1555 0.1611
Schistosoma mansoni hypothetical protein 0.0297 0.1797 0.1865
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0016 0.0022 0.0016
Onchocerca volvulus 0.0016 0.0021 0.0016
Schistosoma mansoni survival motor neuron protein 0.0097 0.0534 0.0539
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Plasmodium falciparum transporter, putative 0.0259 0.1555 1
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.039 0.0827
Brugia malayi PAS domain containing protein 0.0053 0.0251 0.0243
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0123 0.0672
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0108 0.0603 0.0613
Echinococcus granulosus sodium and chloride dependent glycine 0.0259 0.1555 0.155
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0177 0.1037 0.1032
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0674 0.7837
Schistosoma mansoni nAChR subunit 0.005 0.0235 0.0226
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0072 0.0152
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.039 0.0827
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0021 0.0016
Echinococcus multilocularis nAChR subunit 0.0108 0.0603 0.0598
Onchocerca volvulus 0.0259 0.1555 0.1623
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.0414 0.0408
Brugia malayi hypothetical protein 0.0016 0.0022 0.0003
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Echinococcus multilocularis muscleblind protein 0.0145 0.0835 0.0829
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0452
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.003 0.0025
Schistosoma mansoni neuropeptide receptor 0.0227 0.1353 0.1398
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0068 0.0929
Loa Loa (eye worm) glutamate receptor 2 0.0157 0.0909 0.0945
Onchocerca volvulus 0.0078 0.0414 0.0427
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0021 0.0044
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0021 0.0015
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0252 0.0247
Schistosoma mansoni hypothetical protein 0.0079 0.0422 0.0422
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.0414 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.043 0.0425
Schistosoma mansoni biogenic amine receptor 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Conserved protein 0.0075 0.039 0.1271
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0023 0.0064 0.0411
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0047
Brugia malayi excitatory GABA receptor EXP-1A 0.0108 0.0603 0.0613
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.003 0.0062
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0674 0.7837
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.018 0.1039
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0123 0.0107
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0006 0.0087
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.0064 0.015
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.039 0.5795
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1525 0.9555 1
Loa Loa (eye worm) beta-lactamase 0.0075 0.039 0.0403
Loa Loa (eye worm) hypothetical protein 0.0253 0.152 0.1586
Echinococcus multilocularis RUN 0.0041 0.018 0.0175
Leishmania major hypothetical protein, conserved 0.0016 0.0021 0.0044
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.0414 0.0413
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0021 0.0311
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.043 0.0425
Brugia malayi Uncoordinated protein 44 0.0016 0.0019 0.0000000060647
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.039 0.5795
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0674 0.0699
Schistosoma mansoni hypothetical protein 0.0058 0.0286 0.0279
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0123 0.0672
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Plasmodium vivax hypothetical protein, conserved 0.0259 0.1555 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0079 0.0422 0.042
Schistosoma mansoni neurotransmitter gated ion channel 0.005 0.0235 0.0226
Brugia malayi exodeoxyribonuclease III family protein 0.0079 0.0422 0.0422
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0047
Onchocerca volvulus Putative nachr subunit 0.0177 0.1037 0.108
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0674 0.0699
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0452
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.0064 0.015
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0185 0.0179
Onchocerca volvulus 0.0039 0.0165 0.0167
Brugia malayi AKH receptor 0.0078 0.0414 0.0413
Schistosoma mansoni hypothetical protein 0.005 0.0236 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Schistosoma mansoni synaptojanin 0.0016 0.0021 0.0002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0068 0.079
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0023 0.0064 0.0411
Brugia malayi Cytochrome P450 family protein 0.0033 0.0125 0.0111
Brugia malayi beta-lactamase family protein 0.0075 0.039 0.0389
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0125 0.0125
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0173 0.1011 0.1006
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.003 0.0012
Schistosoma mansoni histamine h1 receptor 0.0078 0.0414 0.0413
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Schistosoma mansoni glutamate receptor kainate 0.0157 0.0909 0.0933
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0019 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0094 0.0484
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0177 0.1037 0.108
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0414 0.0408
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0031 0.0025
Schistosoma mansoni ATP-binding cassette transporter 0.0157 0.0909 0.0933
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1611
Brugia malayi hypothetical protein 0.0028 0.0094 0.0079
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.0414 0.0408
Giardia lamblia GTOR 0.0018 0.003 0.0236
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0235 0.0226
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0068 0.0452
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.0093
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0079 0.0422 0.0893
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0252 0.0247
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0068 0.079
Schistosoma mansoni glutamate receptor kainate 0.0157 0.0909 0.0933
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0259 0.1555 0.155
Schistosoma mansoni single-minded 0.0053 0.0251 0.0243
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.0414 0.0408
Brugia malayi metabotropic glutamate receptor type 2 0.0016 0.0022 0.0003
Toxoplasma gondii ABC1 family protein 0.0075 0.039 0.2412
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.1011 0.1006
Schistosoma mansoni lamin 0.0055 0.0269 0.0262
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.1011 0.1006
Schistosoma mansoni hypothetical protein 0.0078 0.0414 0.0413
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Brugia malayi beta-lactamase 0.0075 0.039 0.0389
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0058 0.0288 0.0282
Echinococcus multilocularis nAChR subunit 0.0058 0.0288 0.0282
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0058 0.0288 0.0282
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0023 0.0064 0.0411
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.003 0.0064
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0068 0.0452
Toxoplasma gondii hypothetical protein 0.0259 0.1555 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.2928 1
Brugia malayi hypothetical protein 0.0176 0.1033 0.1063
Onchocerca volvulus 0.0078 0.0414 0.0427
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.039 0.5795
Mycobacterium leprae Probable lipase LipE 0.0075 0.039 0.5759
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.0414 0.0408
Entamoeba histolytica hypothetical protein, conserved 0.0149 0.086 1
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0064 0.0061
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0378 0.08
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0252 0.0247
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.0064 0.015
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0359 0.037
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.1507 0.156
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.0414 0.0427
Loa Loa (eye worm) serotonin transporter b 0.1525 0.9555 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0088 0.0082
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0115 0.0646 0.4077
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0674 0.1427
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Echinococcus multilocularis glutamate receptor 2 0.0173 0.1011 0.1006
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0064 0.0059
Leishmania major protein kinase, putative 0.0019 0.004 0.0085
Onchocerca volvulus 0.0046 0.0212 0.0216
Plasmodium vivax hypothetical protein, conserved 0.0075 0.039 0.2408
Onchocerca volvulus 0.0016 0.0022 0.0017
Echinococcus granulosus glutamate receptor NMDA 0.0084 0.045 0.0444
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0058 0.0286 0.028
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0414 0.0408
Onchocerca volvulus 0.0041 0.018 0.0183
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.005 0.0235 0.0226
Echinococcus multilocularis sodium and chloride dependent glycine 0.0259 0.1555 0.155
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0125 0.0125
Echinococcus multilocularis 0.0023 0.0064 0.0059
Schistosoma mansoni hypothetical protein 0.0023 0.0064 0.0047
Brugia malayi vesicular acetylcholine transporter unc-17 0.0428 0.2626 0.2733
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0422 0.0416
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0123 0.0667
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0094 0.0479
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0021 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.0414 0.0413
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0094 0.02
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.0414 0.0413
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1611
Brugia malayi ERG2 and Sigma1 receptor like protein 0.076 0.4722 0.4932
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0115 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni glutamate receptor AMPA 0.0157 0.0909 0.0933
Schistosoma mansoni lipoxygenase 0.0184 0.1085 0.1117
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) glutamate receptor 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.1525 0.9555 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0021 0.0311
Loa Loa (eye worm) RecQ helicase 0.0024 0.007 0.0067
Mycobacterium leprae conserved hypothetical protein 0.0075 0.039 0.5759
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0017
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0023 0.0064 0.0411
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0012
Echinococcus multilocularis inositol monophosphatase 1 0.0115 0.0646 0.0641
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0177 0.1037 0.1032
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.0064 0.015
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0023 0.0064 0.0411
Loa Loa (eye worm) hypothetical protein 0.0145 0.0835 0.0868
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0288 0.0282
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0378 0.08
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0534 0.0539
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0058 0.0286 0.028
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0125 0.0265
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0674 0.0668
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0646 0.1368
Brugia malayi 6-phosphofructokinase 0.0119 0.0674 0.0686
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.0414 0.0408
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.003 0.0064
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0108 0.0603 0.0598
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0094 0.0479
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0123 0.0758
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.039 0.0389
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0414 0.0408
Brugia malayi larval opioid receptor 0.0078 0.0414 0.0413
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0674 0.7758
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0603 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Brugia malayi mbt repeat family protein 0.0046 0.0212 0.0202
Onchocerca volvulus 0.0041 0.018 0.0183
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0016
Onchocerca volvulus 0.0016 0.0021 0.0016
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0021 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0051
Onchocerca volvulus 0.005 0.0235 0.024
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0414 0.0408
Onchocerca volvulus 0.0078 0.0414 0.0427
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.003 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0204 0.0193
Brugia malayi Dopamine receptor protein 2 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi intermediate filament protein 0.0055 0.0269 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0087
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0031 0.0066
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0021 0.0311
Loa Loa (eye worm) glutamate receptor 1 0.0157 0.0909 0.0945
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0079 0.0422 0.0416
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.1525 0.9555 1
Brugia malayi hypothetical protein 0.0259 0.1555 0.1611
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0064 0.0137
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0079 0.0422 0.0435
Schistosoma mansoni vesicular acetylcholine transporter 0.0428 0.2626 0.2733
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0017
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0031 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis allatostatin A receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0674 1
Brugia malayi G-protein coupled receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0022 0.0017
Schistosoma mansoni myosin xvIII 0.0078 0.0414 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) norepinephrine transporter 0.1525 0.9555 1
Brugia malayi hypothetical protein 0.0476 0.293 0.3052
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Schistosoma mansoni tyrosine kinase 0.0016 0.0022 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0019 0.0014
Brugia malayi Muscleblind-like protein 0.0145 0.0835 0.0855
Schistosoma mansoni sodium/chloride dependent transporter 0.1525 0.9555 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.0414 0.0408
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Schistosoma mansoni cytochrome P450 0.0023 0.0064 0.0047
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0177 0.1037 0.1032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0184 0.1085 0.108
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0422 0.0436
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.0414 0.0413
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0414 0.0408
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.0064 0.015
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0123 0.0758
Schistosoma mansoni nocturnin 0.0016 0.0021 0.0002
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.018 0.0175
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0014
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.039 0.4342
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.003 0.0064
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0414 0.0413
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0038 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Onchocerca volvulus 0.0075 0.039 0.0403
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.018 0.0182
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0674 0.1427
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0212 0.0206
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0378 0.0376
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0674 0.0685
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0259 0.1555 0.155
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0065
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0068 0.0452
Onchocerca volvulus 0.0078 0.0414 0.0427
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.0414 0.0408
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Onchocerca volvulus 0.0055 0.0269 0.0276
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.003 0.0064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0079 0.0422 0.0893
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0021 0.0044
Mycobacterium ulcerans hypothetical protein 0.0149 0.086 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.0414 0.0427
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.0064 0.015
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0064 0.0137
Loa Loa (eye worm) hypothetical protein 0.0176 0.1033 0.1076
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.003 0.0064
Echinococcus granulosus single minded 2 0.0043 0.0189 0.0183
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Onchocerca volvulus 0.0075 0.039 0.0403
Brugia malayi neuropeptide F receptor 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.039 0.1271
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0452
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.005 0.0235 0.0229
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0021 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.039 0.5795
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0016
Onchocerca volvulus 0.0058 0.0288 0.0296
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.003 0.0354
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0259 0.1555 0.1611
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.076 0.4722 0.4939
Onchocerca volvulus 0.0259 0.1555 0.1623
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.018 0.0175
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0078 0.0414 0.0413
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0023 0.0064 0.0411
Plasmodium falciparum amino acid transporter, putative 0.0259 0.1555 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0064 0.0137
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0006 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0023 0.0064 0.0411
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.003 0.0064
Echinococcus multilocularis serotonin receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.003 0.0062
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0414 0.0408
Echinococcus granulosus lamin dm0 0.0055 0.0269 0.0263
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.005 0.0235 0.0229
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0252 0.0247
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0414 0.0413
Echinococcus multilocularis vesicular acetylcholine transporter 0.0428 0.2626 0.2621
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0177 0.1037 0.1032
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0212 0.0216
Echinococcus granulosus sphingosine kinase 1 0.0149 0.086 0.0854
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0064 0.0137
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.039 0.1271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.0414 0.0413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.005 0.0235 0.0229
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Echinococcus granulosus muscleblind protein 0.0145 0.0835 0.0829
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0021 0.0044
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.003 0.0025
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0021 0.0002
Onchocerca volvulus 0.0023 0.0068 0.0065
Brugia malayi Dopamine receptor 0.0078 0.0414 0.0413
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0021 0.0044
Schistosoma mansoni neurotransmitter gated ion channel 0.0058 0.0288 0.0282
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0023 0.0064 0.0411
Onchocerca volvulus 0.0055 0.0269 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus multilocularis sodium and chloride dependent glycine 0.0259 0.1555 0.155
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0674 0.7837
Schistosoma mansoni lamin 0.0055 0.0269 0.0262
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0021 0.0015
Echinococcus granulosus microtubule associated protein 2 0.1465 0.9175 0.9175
Echinococcus granulosus glutamate receptor 2 0.0173 0.1011 0.1006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.0414 0.0408
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Brugia malayi 6-phosphofructokinase 0.0119 0.0674 0.0686
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0259 0.1555 1
Echinococcus multilocularis sphingosine kinase 1 0.0149 0.086 0.0854
Loa Loa (eye worm) RNA binding protein 0.007 0.0359 0.037
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0021 0.0311
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0259 0.1555 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0674 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0064
Schistosoma mansoni cript-related 0.0016 0.0021 0.0002
Onchocerca volvulus 0.0078 0.0414 0.0427
Leishmania major hypothetical protein, conserved 0.0016 0.0021 0.0044
Schistosoma mansoni hypothetical protein 0.0079 0.0422 0.0422
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0259 0.1555 0.1611
Mycobacterium leprae putative cytochrome p450 0.0023 0.0064 0.0878
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Brugia malayi Protein kinase domain containing protein 0.0016 0.0019 0.0000000060647
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0674 0.0686
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.018 0.0174
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni hypothetical protein 0.0172 0.1005 0.1033
Echinococcus multilocularis neuropeptide s receptor 0.0078 0.0414 0.0408
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.003 0.0025
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0021 0.0244
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.018 0.0175
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0015
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0252 0.0244
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0016 0.0022 0.0016
Echinococcus multilocularis serotonin transporter 0.1525 0.9555 0.9555
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0422 0.2611
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.0414 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Brugia malayi hypothetical protein 0.0041 0.018 0.0169
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0023 0.0064 0.0411
Brugia malayi Cation transporter family protein 0.0253 0.152 0.1574
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0331 0.2009 0.2098
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0108 0.0603 0.0613
Onchocerca volvulus 0.0075 0.039 0.0403
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.039 0.4342
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0646 0.959
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0072 0.0066
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1586 0.9943 0.9943
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0017
Echinococcus granulosus Ankyrin 0.0016 0.002 0.0014
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.0552 0.0546
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus glutamate NMDA receptor subunit 0.0333 0.2022 0.2017
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.0414 0.0408
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0269 0.0276
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0058 0.0286 0.028
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0184 0.1085 0.108
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0835 0.0829
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0378 0.0372
Echinococcus granulosus neuropeptide receptor 0.0227 0.1353 0.1348
Echinococcus granulosus hypothetical protein 0.0078 0.0414 0.0408
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0125 0.0125
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0019 0.0014
Echinococcus granulosus metabotropic glutamate receptor 5 0.0016 0.0022 0.0016
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0204 0.1207 0.1258
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0603 0.0613
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0072 0.0152
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.0414 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Brugia malayi cytochrome P450 0.0023 0.0064 0.0047
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0047
Schistosoma mansoni protein kinase 0.0016 0.0022 0.0003
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.0414 0.0413
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.0414 0.0408
Brugia malayi TAR-binding protein 0.007 0.0359 0.0356
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0068 0.0162
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0006 0.0087
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0259 0.1555 0.155
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0031 0.0066
Echinococcus granulosus serotonin receptor 0.0078 0.0414 0.0408
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1611
Schistosoma mansoni neurotransmitter gated ion channel 0.005 0.0235 0.0226
Loa Loa (eye worm) hypoxia-induced factor 1 0.0163 0.0947 0.0985
Onchocerca volvulus 0.0078 0.0414 0.0427
Leishmania major cytochrome p450-like protein 0.0033 0.0125 0.0265
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0079 0.0422 0.0893
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0016 0.0022 0.0003
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0674 0.0699
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0183
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0022 0.0003
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.003 0.0026
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.005 0.0235 0.0226
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0163 0.2414
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.008
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0288 0.0282
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0378 0.08
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.005 0.0235 0.024
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0021 0.0244
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.018 0.1039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.039 0.0403
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0021 0.0311
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0378 0.0389
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0603 0.0613
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Schistosoma mansoni nAChR subunit 0.005 0.0235 0.0226
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0006 0.0012
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Onchocerca volvulus 0.0078 0.0414 0.0427
Brugia malayi Inositol-1 0.0115 0.0646 0.0657
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0021 0.0015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0414 0.0408
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0006 0.0012
Echinococcus granulosus glutamate receptor subunit protein glur 0.0058 0.0286 0.028
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0108 0.0603 0.0598
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1623
Loa Loa (eye worm) hypothetical protein 0.0145 0.0835 0.0868
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.039 0.1271
Onchocerca volvulus 0.0078 0.0414 0.0427
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0125 0.0265
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.0064 0.015
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.0414 0.0413
Echinococcus multilocularis synaptic vesicular amine transporter 0.0204 0.1207 0.1202
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0079 0.0422 0.0893
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0123 0.0667
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0058 0.0286 0.028
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Brugia malayi hypothetical protein 0.0041 0.018 0.0169
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.003 0.0159
Schistosoma mansoni hypothetical protein 0.0041 0.018 0.0169
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0107 0.0106
Leishmania major hypothetical protein, conserved 0.0016 0.0021 0.0044
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0414 0.0408
Echinococcus granulosus glutamate receptor 2 0.0115 0.0645 0.064
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0378 0.08
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.0414 0.0408
Leishmania major hypothetical protein, conserved 0.0075 0.039 0.0827
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0422 0.0422
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.0414 0.0408
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.003 0.0033
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.007 0.1041
Leishmania major C-8 sterol isomerase-like protein 0.076 0.4722 1
Echinococcus granulosus neuropeptide receptor 0.0078 0.0414 0.0408
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0422 0.2611
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0422 0.6258
Echinococcus multilocularis orexin receptor type 2 0.0078 0.0414 0.0408
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0068 0.0929
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0165 0.0153
Onchocerca volvulus 0.0078 0.0414 0.0427
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0125 0.0265
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0414 0.0408
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0108 0.0603 0.0598
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0428 0.2626 0.2743
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0064 0.0137
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0088 0.0082
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0259 0.1555 1
Loa Loa (eye worm) TAR-binding protein 0.007 0.0359 0.037
Toxoplasma gondii hypothetical protein 0.0259 0.1555 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0108 0.0603 0.0626
Echinococcus granulosus tar DNA binding protein 0.007 0.0359 0.0353
Trichomonas vaginalis inositol monophosphatase, putative 0.0115 0.0646 0.959
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0103 0.057 0.1889
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0108 0.0603 0.0613
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni ap endonuclease 0.0079 0.0422 0.0422
Echinococcus granulosus nmda type glutamate receptor 0.01 0.0552 0.0546
Echinococcus granulosus death domain containing protein 0.0016 0.0019 0.0013
Onchocerca volvulus 0.0108 0.0603 0.0626
Brugia malayi Cation transporter family protein 0.0108 0.0603 0.0613
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0021 0.0003
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0021 0.0015
Entamoeba histolytica hypothetical protein 0.0024 0.0072 0.0835
Onchocerca volvulus 0.0108 0.0603 0.0626
Trypanosoma cruzi extracellular receptor, putative 0.0016 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0359 0.0356
Brugia malayi Glutamate receptor 1 precursor 0.0157 0.0909 0.0933
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0019 0.0013
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0068 0.0452
Schistosoma mansoni glutamate receptor NMDA 0.0333 0.2022 0.21
Loa Loa (eye worm) hypothetical protein 0.0995 0.6206 0.6493
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0079 0.0422 1
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0021 0.0311
Brugia malayi MH2 domain containing protein 0.0119 0.067 0.0682
Onchocerca volvulus 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Mycobacterium ulcerans lipase LipD 0.0075 0.039 0.4342
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0108 0.0603 0.0626
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0212 0.0202
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0107 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.0064 0.015
Echinococcus multilocularis synaptojanin 1 0.0016 0.0021 0.0015
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.008
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Mycobacterium ulcerans beta-lactamase 0.0075 0.039 0.4342
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0023 0.0064 0.0411
Onchocerca volvulus 0.0078 0.0414 0.0427
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0006 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Onchocerca volvulus 0.0097 0.0534 0.0553
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0017 0.0027 0.0057
Schistosoma mansoni sphingosine kinase A B 0.0149 0.086 0.0881
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0031 0.0066
Brugia malayi Death domain containing protein 0.0016 0.0019 0.0000000060647
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0235 0.0226
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Schistosoma mansoni hypothetical protein 0.1054 0.6582 0.6882
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0204 0.0193
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0023 0.0064 0.0411
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0123 0.1831
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.1011 0.1006
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.0414 0.0408
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.003 0.0064
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0072 0.0066
Leishmania major pantothenate kinase subunit, putative 0.0017 0.0027 0.0057
Onchocerca volvulus 0.0078 0.0414 0.0427
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.018 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0046 0.0212 0.0216
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0183
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0023 0.0064 0.0411
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.003 0.0064
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0414 0.0408
Echinococcus granulosus vesicular acetylcholine transporter 0.0428 0.2626 0.2621
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0259 0.1555 0.1611
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni vesicular amine transporter 0.0204 0.1207 0.1246
Schistosoma mansoni neuropeptide receptor 0.0078 0.0414 0.0413
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0422 0.0416
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0288 0.0282
Schistosoma mansoni hypothetical protein 0.0078 0.0414 0.0413
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0259 0.1555 0.155
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0252 0.0244
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0378 0.0376
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.0012
Schistosoma mansoni sphingoid long chain base kinase 0.0149 0.086 0.0881
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0422 0.6258
Brugia malayi RE15519p 0.0078 0.0414 0.0413
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Leishmania major protein kinase, putative 0.0014 0.0006 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.067 0.0695
Loa Loa (eye worm) hypothetical protein 0.0995 0.6206 0.6493
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0021 0.0244
Echinococcus multilocularis tar DNA binding protein 0.007 0.0359 0.0353
Brugia malayi Doublecortin family protein 0.0041 0.018 0.0169
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0031 0.0025
Echinococcus multilocularis bloom syndrome protein 0.0024 0.007 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.039 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.0064 0.015
Schistosoma mansoni microtubule-associated protein tau 0.1465 0.9175 0.9602
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0646 0.1368
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0674 0.0686
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0674 0.2246
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0023 0.0064 0.0411
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0115 0.0646 0.7424
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0108 0.0603 0.0598
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0165 0.0159
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0388 0.2374 0.248
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0251 0.0243
Brugia malayi Serotonin receptor 0.0078 0.0414 0.0413
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0064
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0428 0.2626 0.2743
Echinococcus multilocularis serotonin receptor 0.0078 0.0414 0.0408
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Echinococcus granulosus g protein coupled receptor 0.0078 0.0414 0.0408
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0414 0.0413
Echinococcus granulosus metabotropic glutamate receptor 2 0.0016 0.0022 0.0016
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0177 0.1037 0.1032
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0674 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni ap endonuclease 0.0079 0.0422 0.0422
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0064 0.0289
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0646 0.1368
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0177 0.1037 0.1067
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.0064 0.015
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0072 0.1065
Schistosoma mansoni hypothetical protein 0.0079 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0414 0.0408
Echinococcus granulosus fmrfamide receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.003 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0674 1
Brugia malayi hypothetical protein 0.0018 0.0032 0.0014
Schistosoma mansoni synaptojanin 0.0016 0.0021 0.0002
Schistosoma mansoni lipoxygenase 0.011 0.0616 0.0625
Schistosoma mansoni sodium/chloride dependent transporter 0.0259 0.1555 0.1611
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Schistosoma mansoni tyrosine kinase 0.0016 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Loa Loa (eye worm) doublecortin family protein 0.0041 0.018 0.0183
Loa Loa (eye worm) hypothetical protein 0.1525 0.9555 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Echinococcus multilocularis receptor type guanylyl cyclase 0.0016 0.0022 0.0016
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.293 0.2926
Echinococcus multilocularis glutamate receptor 2 0.0115 0.0645 0.064
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0022 0.0003
Mycobacterium tuberculosis Conserved protein 0.0075 0.039 0.1271
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0031 0.0071
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0022 0.0017
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0108 0.0603 0.0613
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.003 0.0012
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0031 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.0144
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0414 0.0427
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.0064 0.015
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.0064 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Mycobacterium tuberculosis Conserved protein 0.0149 0.086 0.2885
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0031 0.0035
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Schistosoma mansoni biogenic amine receptor 0.0078 0.0414 0.0413
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.0414 0.0408
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0064 0.0878
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0123 0.2555
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0022 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0378 0.0372
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0065
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0072 0.0055
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.0064 0.015
Schistosoma mansoni glutamate receptor NMDA 0.0257 0.1541 0.1596
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0414 0.0408
Brugia malayi G protein-coupled receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.0414 0.0413
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0072 0.0336
Echinococcus multilocularis lamin 0.0055 0.0269 0.0263
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.1507 0.1572
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0031 0.0066
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0103 0.057 0.8446
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0177 0.1037 0.1032
Schistosoma mansoni acetylcholine receptor-related 0.005 0.0235 0.0226
Schistosoma mansoni adenoreceptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) ACC-1 protein 0.0108 0.0603 0.0626
Entamoeba histolytica hypothetical protein 0.0058 0.0288 0.3351
Schistosoma mansoni opsin-like receptor 0.0078 0.0414 0.0413
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0019 0.0000000060647
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0212 0.0206
Echinococcus granulosus g protein coupled receptor 0.0078 0.0414 0.0408
Schistosoma mansoni acetylcholine receptor subunit beta 0.005 0.0235 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.0414 0.0427
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0021 0.0015
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0125 0.1144
Schistosoma mansoni inositol monophosphatase 0.0115 0.0646 0.0657
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0012
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0414 0.0408
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0023 0.0064 0.0411
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.0414 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Schistosoma mansoni inositol monophosphatase 0.0115 0.0646 0.0657
Mycobacterium ulcerans hypothetical protein 0.0023 0.0068 0.0452
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0414 0.0408
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0108 0.0603 0.0626
Brugia malayi GnHR receptor homolog 0.0078 0.0414 0.0413
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0108 0.0603 0.0598
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0094 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0414 0.0408
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.003 0.0354
Loa Loa (eye worm) GABA receptor subunit 0.0058 0.0288 0.0296
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0079 0.0422 0.0416
Brugia malayi beta-lactamase family protein 0.0075 0.039 0.0389
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1595 1 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0259 0.1555 0.155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Brugia malayi Cation transporter family protein 0.0108 0.0603 0.0613
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.007 0.0053
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0021 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0414 0.0413
Echinococcus granulosus glycine receptor subunit beta 0.0108 0.0603 0.0598
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.0064 0.015
Echinococcus granulosus tyrosine kinase 0.0016 0.0022 0.0016
Echinococcus granulosus nAChR subunit 0.0058 0.0288 0.0282
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.1011 0.1006
Echinococcus multilocularis nmda type glutamate receptor 0.0142 0.0816 0.081
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0259 0.1555 0.155
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0414 0.0408
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.018 0.0175
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Echinococcus granulosus bloom syndrome protein 0.0024 0.007 0.0064
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Schistosoma mansoni opsin-like receptor 0.0078 0.0414 0.0413
Onchocerca volvulus 0.005 0.0235 0.024
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0031 0.0066
Onchocerca volvulus 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0051
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0006 0.0087
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0269 0.0262
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0087
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0253 0.152 0.1574
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0058 0.0286 0.028
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.039 0.5795
Echinococcus granulosus geminin 0.1054 0.6582 0.658
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0108 0.0603 0.0613
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.0414 0.0413
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.0414 0.0413
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0108 0.0603 0.0626
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0019 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.0144
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Echinococcus granulosus serotonin transporter 0.1525 0.9555 0.9555
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus allatostatin A receptor 0.0078 0.0414 0.0408
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0674 0.0668
Echinococcus granulosus nAChR subunit 0.0108 0.0603 0.0598
Brugia malayi ORL1-like opioid receptor 0.0078 0.0414 0.0413
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0079 0.0422 0.4904
Brugia malayi Serotonin receptor 0.0078 0.0414 0.0413
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.005 0.0235 0.0229
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0031 0.0066
Loa Loa (eye worm) inositol-1 0.0115 0.0646 0.067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0235 0.0226
Brugia malayi Dopamine receptor protein 1 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus somatostatin receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.0414 0.0427
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0021 0.0002
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0108 0.0603 0.0598
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0016 0.0022 0.0017
Echinococcus multilocularis sex peptide receptor 0.0078 0.0414 0.0408
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0259 0.1555 0.155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0023 0.0064 0.0411
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0031 0.0071
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.003 0.0064
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0019 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.1507 0.156
Schistosoma mansoni rab6-interacting 0.0041 0.018 0.0169
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0072 0.0055
Mycobacterium tuberculosis Conserved protein 0.0075 0.039 0.1271
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trichomonas vaginalis esterase, putative 0.0075 0.039 0.5795
Schistosoma mansoni biogenic amine receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.0064 0.015
Brugia malayi CCR4 0.0016 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0149 0.086 0.0894
Onchocerca volvulus 0.0108 0.0603 0.0626
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0012
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1173 0.1167
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.039 0.0385
Brugia malayi phosphofructokinase 0.0119 0.0674 0.0686
Onchocerca volvulus 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Plasmodium vivax amine transporter, putative 0.0259 0.1555 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0603 0.0613
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0052 0.0201
Echinococcus granulosus GPCR family 2 0.0079 0.0422 0.0416
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.005 0.0107
Echinococcus granulosus sex peptide receptor 0.0078 0.0414 0.0408
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0021 0.0044
Echinococcus multilocularis G protein coupled receptor 139 0.0227 0.1353 0.1348
Echinococcus granulosus synaptojanin 1 0.0016 0.0021 0.0015
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.002 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.003 0.0012
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.0414 0.0408
Leishmania major cytochrome p450-like protein 0.0023 0.0064 0.0137
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0068 0.079
Echinococcus multilocularis neuropeptide receptor 0.0227 0.1353 0.1348
Echinococcus multilocularis tyrosine kinase 0.0016 0.0022 0.0016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0079 0.0422 0.4717
Echinococcus granulosus inositol monophosphatase 1 0.0115 0.0646 0.0641
Brugia malayi Abnormal catecholamine distribution protein 1 0.0204 0.1207 0.1246
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Echinococcus granulosus RUN 0.0041 0.018 0.0175
Onchocerca volvulus 0.0078 0.0414 0.0427
Brugia malayi follicle stimulating hormone receptor 0.0331 0.2009 0.2087
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0212 0.0206
Onchocerca volvulus 0.0253 0.152 0.1586
Schistosoma mansoni hypothetical protein 0.0097 0.0534 0.0539
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Loa Loa (eye worm) hypothetical protein 0.0053 0.0252 0.0258
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0378 0.4392
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0123 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Brugia malayi mbt repeat family protein 0.0046 0.0212 0.0202
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Loa Loa (eye worm) hypothetical protein 0.0251 0.1507 0.1572
Echinococcus granulosus g protein coupled receptor 0.0078 0.0414 0.0408
Brugia malayi Glutamate receptor 2 precursor 0.0157 0.0909 0.0933
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0031 0.0025
Schistosoma mansoni glutamate receptor kainate 0.0157 0.0909 0.0933
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.0012
Schistosoma mansoni hypothetical protein 0.0079 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi Guanylyl cyclase protein 23 0.0016 0.0022 0.0003
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.005 0.0235 0.0229
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.293 0.2926
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0021 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0177 0.1037 0.108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0065
Onchocerca volvulus 0.0058 0.0288 0.0296
Loa Loa (eye worm) hypothetical protein 0.0054 0.0263 0.0269
Brugia malayi isocitrate dehydrogenase 0.0018 0.0031 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0006 0.0012
Echinococcus multilocularis lamin dm0 0.0055 0.0269 0.0263
Trypanosoma cruzi C-8 sterol isomerase, putative 0.076 0.4722 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.1525 0.9555 1
Echinococcus multilocularis neuropeptide receptor A26 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi Metabotropic glutamate receptor precursor. 0.0016 0.0022 0.0003
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0021 0.0044
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0674 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0414 0.0408
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.067 0.0695
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Echinococcus granulosus sodium and chloride dependent glycine 0.0259 0.1555 0.155
Brugia malayi sulfakinin receptor protein 0.0078 0.0414 0.0413
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.003 0.0064
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.039 0.1271
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0021 0.0044
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0021 0.0311
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0163 0.2414
Echinococcus multilocularis microtubule associated protein 2 0.1465 0.9175 0.9175
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0414 0.0408
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0173 0.1011 0.1006
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Onchocerca volvulus 0.0016 0.0022 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Echinococcus multilocularis GPCR, family 2 0.0079 0.0422 0.0416
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Echinococcus granulosus neuropeptide s receptor 0.0078 0.0414 0.0408
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Leishmania major hypothetical protein, conserved 0.0028 0.0094 0.02
Echinococcus multilocularis NMDA receptor 0.0058 0.0286 0.028
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0021 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0051
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0253 0.152 0.1574
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0422 0.0422
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0064

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Activation of human P-gp ATPase in human Caco2 cells at 100 uM ChEMBL. 18276145
Activity (binding) 0 Activation of human P-gp ATPase in human Caco2 cells at 100 uM ChEMBL. 18276145
EC50 (binding) = 0.3 uM Inhibition of human P-gp mediated [3H]vinblastine transport activity in human Caco2 cells ChEMBL. 18276145
Papp (ADMET) = 187 nm/s Apparent permeability from basolateral to apical side of human Caco2 cell membrane ChEMBL. 18276145
Papp (ADMET) = 187 nm/s Apparent permeability from basolateral to apical side of human Caco2 cell membrane ChEMBL. 18276145
Papp (ADMET) = 237 nm/s Apparent permeability from apical to basoleteral side of human Caco2 cell membrane ChEMBL. 18276145
Papp (ADMET) = 237 nm/s Apparent permeability from apical to basoleteral side of human Caco2 cell membrane ChEMBL. 18276145
Ratio (ADMET) = 3.6 Ratio of permeability from apical to basoleteral over basoleteral to apical side of human Caco2 cell membrane ChEMBL. 18276145

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.