Detailed information for compound 515099

Basic information

Technical information
  • TDR Targets ID: 515099
  • Name: 6,7-dimethoxy-2-(naphthalen-2-ylmethyl)-3,4-d ihydro-1H-isoquinoline
  • MW: 333.424 | Formula: C22H23NO2
  • H donors: 0 H acceptors: 0 LogP: 4.48 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2CN(CCc2cc1OC)Cc1ccc2c(c1)cccc2
  • InChi: 1S/C22H23NO2/c1-24-21-12-19-9-10-23(15-20(19)13-22(21)25-2)14-16-7-8-17-5-3-4-6-18(17)11-16/h3-8,11-13H,9-10,14-15H2,1-2H3
  • InChiKey: PJCLDWQOWBBYNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,7-dimethoxy-2-(2-naphthylmethyl)-3,4-dihydro-1H-isoquinoline
  • 6,7-dimethoxy-2-(2-naphthalenylmethyl)-3,4-dihydro-1H-isoquinoline
  • Oprea1_619846

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0212 0.0216
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0123 0.0672
Echinococcus granulosus g-protein coupled receptor 0.0078 0.0414 0.0408
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0674 0.1427
Leishmania major extracellular receptor, putative 0.0016 0.0022 0.0046
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.0064 0.015
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0123 0.0667
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus orexin receptor type 2 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0203 0.1204 0.1255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Entamoeba histolytica hypothetical protein 0.0016 0.0022 0.0255
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.0064 0.015
Schistosoma mansoni neuropeptide receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0422 0.0416
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0023 0.0064 0.0411
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.0414 0.0427
Echinococcus multilocularis musashi 0.0055 0.0269 0.0263
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0259 0.1555 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.007 0.1041
Toxoplasma gondii exonuclease III APE 0.0079 0.0422 0.2615
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0023 0.0064 0.0411
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0058 0.0288 0.0282
Schistosoma mansoni opsin-like receptor 0.0078 0.0414 0.0413
Onchocerca volvulus 0.1525 0.9555 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.003 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.1005 0.1033
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0115 0.0646 0.7516
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0031 0.0012
Loa Loa (eye worm) hypothetical protein 0.0476 0.293 0.3062
Brugia malayi Cytochrome P450 family protein 0.0033 0.0125 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0023 0.0064 0.0411
Onchocerca volvulus 0.0078 0.0414 0.0427
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Echinococcus granulosus lamin 0.0055 0.0269 0.0263
Echinococcus granulosus receptor type guanylyl cyclase 0.0016 0.0022 0.0016
Echinococcus multilocularis glycine receptor subunit beta 0.0108 0.0603 0.0598
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.1011 0.1006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.0064 0.015
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis geminin 0.1054 0.6582 0.658
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.039 0.1271
Echinococcus multilocularis glycine receptor subunit beta 0.0108 0.0603 0.0598
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Schistosoma mansoni hypothetical protein 0.0078 0.0414 0.0413
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0123 0.1435
Onchocerca volvulus 0.0259 0.1555 0.1623
Schistosoma mansoni loxhd1 0.0041 0.018 0.0169
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus granulosus intermediate filament protein 0.0055 0.0269 0.0263
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0021 0.0311
Onchocerca volvulus 0.0253 0.152 0.1586
Treponema pallidum sodium- and chloride- dependent transporter 0.1525 0.9555 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0333 0.2022 0.2017
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0212 0.0206
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0108 0.0603 0.0613
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.018 0.0175
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0006 0.0087
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.039 0.1271
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0021 0.0044
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0108 0.0603 0.0598
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Echinococcus multilocularis somatostatin receptor 0.0078 0.0414 0.0408
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.0144
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.0414 0.0427
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0108 0.0603 0.0598
Loa Loa (eye worm) MBCTL1 0.0053 0.0252 0.0258
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0414 0.0408
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Brugia malayi RNA binding protein 0.007 0.0359 0.0356
Loa Loa (eye worm) cytochrome P450 0.0023 0.0064 0.0061
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0031 0.0066
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0646 0.1368
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.039 0.1271
Loa Loa (eye worm) hypothetical protein 0.0253 0.152 0.1586
Schistosoma mansoni sodium/chloride dependent transporter 0.0259 0.1555 0.1611
Brugia malayi hypoxia-induced factor 1 0.0163 0.0947 0.0973
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0269 0.0276
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni hypothetical protein 0.1054 0.6582 0.6882
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0021 0.0002
Schistosoma mansoni glutamate receptor AMPA 0.0157 0.0909 0.0933
Leishmania major cytochrome p450-like protein 0.0023 0.0064 0.0137
Onchocerca volvulus 0.0253 0.152 0.1586
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1173 0.1167
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.005 0.0235 0.0226
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.039 0.0389
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0078 0.0414 0.0413
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0414 0.0413
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0021 0.0311
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0058 0.0286 0.028
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Loa Loa (eye worm) LGC-31 protein 0.0108 0.0603 0.0626
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0212 0.0202
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0094 0.02
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0108 0.0603 0.0626
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.0414 0.0408
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.039 0.0827
Schistosoma mansoni polycystin 1-related 0.0041 0.018 0.0169
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0058 0.0286 0.028
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0108 0.0603 0.0598
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Brugia malayi Melatonin receptor type 1A 0.0078 0.0414 0.0413
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.005 0.0235 0.024
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0016 0.0022 0.0016
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0023 0.0064 0.0411
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0079 0.0422 0.1378
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.003 0.0064
Echinococcus granulosus neuropeptide receptor A26 0.0078 0.0414 0.0408
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.018 0.0175
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.0414 0.0413
Echinococcus granulosus synaptic vesicular amine transporter 0.0204 0.1207 0.1202
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Echinococcus granulosus glycine receptor subunit beta 0.0108 0.0603 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0087
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.1011 0.1006
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0185 0.0179
Echinococcus multilocularis glutamate receptor 2 0.0157 0.0909 0.0903
Onchocerca volvulus 0.0078 0.0414 0.0427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Echinococcus granulosus nmda type glutamate receptor 0.0142 0.0816 0.081
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Echinococcus multilocularis Ankyrin 0.0016 0.002 0.0014
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0021 0.0044
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.0414 0.0413
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0021 0.0244
Echinococcus multilocularis glutamate receptor NMDA 0.0084 0.045 0.0444
Loa Loa (eye worm) hypothetical protein 0.0172 0.1005 0.1046
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.0064 0.015
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.0414 0.0413
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0055 0.0269 0.0276
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.0064 0.015
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0023 0.0064 0.0411
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0603 0.0613
Brugia malayi putative neuropeptide receptor 0.0078 0.0414 0.0413
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0422 0.0416
Echinococcus granulosus atrial natriuretic peptide receptor 0.0016 0.0022 0.0016
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0023 0.0064 0.0411
Mycobacterium tuberculosis Conserved protein 0.0075 0.039 0.1271
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0047
Brugia malayi excitatory GABA receptor EXP-1A 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.043 0.0425
Schistosoma mansoni hypothetical protein 0.0079 0.0422 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.0414 0.0413
Schistosoma mansoni biogenic amine receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) beta-lactamase 0.0075 0.039 0.0403
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1525 0.9555 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.0064 0.015
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0006 0.0087
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.039 0.5795
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0123 0.0107
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.018 0.1039
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.003 0.0062
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0674 0.7837
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0674 0.0699
Schistosoma mansoni hypothetical protein 0.0058 0.0286 0.0279
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0123 0.0672
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.039 0.5795
Brugia malayi Uncoordinated protein 44 0.0016 0.0019 0.0000000060647
Schistosoma mansoni neurotransmitter gated ion channel 0.005 0.0235 0.0226
Treponema pallidum exodeoxyribonuclease (exoA) 0.0079 0.0422 0.042
Plasmodium vivax hypothetical protein, conserved 0.0259 0.1555 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Echinococcus multilocularis RUN 0.0041 0.018 0.0175
Loa Loa (eye worm) hypothetical protein 0.0253 0.152 0.1586
Leishmania major hypothetical protein, conserved 0.0016 0.0021 0.0044
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.043 0.0425
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.0414 0.0413
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0021 0.0311
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0674 0.0699
Onchocerca volvulus Putative nachr subunit 0.0177 0.1037 0.108
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0185 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0452
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.0064 0.015
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0021 0.0015
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0079 0.0422 0.0422
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0068 0.079
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Schistosoma mansoni synaptojanin 0.0016 0.0021 0.0002
Brugia malayi AKH receptor 0.0078 0.0414 0.0413
Onchocerca volvulus 0.0039 0.0165 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Schistosoma mansoni hypothetical protein 0.005 0.0236 0.0228
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0173 0.1011 0.1006
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0125 0.0125
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.003 0.0012
Schistosoma mansoni histamine h1 receptor 0.0078 0.0414 0.0413
Brugia malayi Cytochrome P450 family protein 0.0033 0.0125 0.0111
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0023 0.0064 0.0411
Brugia malayi beta-lactamase family protein 0.0075 0.039 0.0389
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1611
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.0414 0.0408
Brugia malayi hypothetical protein 0.0028 0.0094 0.0079
Giardia lamblia GTOR 0.0018 0.003 0.0236
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0177 0.1037 0.108
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0414 0.0408
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Schistosoma mansoni glutamate receptor kainate 0.0157 0.0909 0.0933
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0019 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0094 0.0484
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0031 0.0025
Schistosoma mansoni ATP-binding cassette transporter 0.0157 0.0909 0.0933
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0068 0.079
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0252 0.0247
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0079 0.0422 0.0893
Schistosoma mansoni single-minded 0.0053 0.0251 0.0243
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.0414 0.0408
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0259 0.1555 0.155
Schistosoma mansoni glutamate receptor kainate 0.0157 0.0909 0.0933
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0235 0.0226
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.0093
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0068 0.0452
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1623
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0414 0.0408
Schistosoma mansoni neuropeptide receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0036 0.0145 0.0146
Brugia malayi neuropeptide F receptor 0.0078 0.0414 0.0413
Schistosoma mansoni intermediate filament proteins 0.0055 0.0269 0.0262
Onchocerca volvulus 0.005 0.0235 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0094 0.02
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0086
Mycobacterium ulcerans hypothetical protein 0.0075 0.039 0.4342
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0068 0.0162
Loa Loa (eye worm) hypothetical protein 0.0079 0.0422 0.0436
Brugia malayi G-protein coupled receptor 0.0078 0.0414 0.0413
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Loa Loa (eye worm) ACC-1 protein 0.0108 0.0603 0.0626
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0108 0.0603 0.0613
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.039 0.0389
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0212 0.0202
Schistosoma mansoni rab6-interacting 0.0041 0.018 0.0169
Trypanosoma brucei C-8 sterol isomerase, putative 0.076 0.4722 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.003 0.0025
Schistosoma mansoni hypothetical protein 0.0078 0.0414 0.0413
Loa Loa (eye worm) acetylcholine receptor protein 0.005 0.0235 0.024
Schistosoma mansoni hypothetical protein 0.0297 0.1797 0.1865
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0016 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni survival motor neuron protein 0.0097 0.0534 0.0539
Onchocerca volvulus 0.0016 0.0021 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0646 0.959
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0165 0.1626
Schistosoma mansoni sodium-dependent amino acid transporter 0.0259 0.1555 0.1611
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1525 0.9555 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.018 0.0168
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0123 0.0672
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0021 0.0015
Plasmodium falciparum transporter, putative 0.0259 0.1555 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.039 0.0827
Brugia malayi PAS domain containing protein 0.0053 0.0251 0.0243
Schistosoma mansoni nAChR subunit 0.005 0.0235 0.0226
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0674 0.7837
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0072 0.0152
Echinococcus granulosus sodium and chloride dependent glycine 0.0259 0.1555 0.155
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0108 0.0603 0.0613
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0177 0.1037 0.1032
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0452
Echinococcus multilocularis muscleblind protein 0.0145 0.0835 0.0829
Schistosoma mansoni neuropeptide receptor 0.0227 0.1353 0.1398
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.003 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.039 0.0827
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0021 0.0016
Echinococcus multilocularis nAChR subunit 0.0108 0.0603 0.0598
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Brugia malayi hypothetical protein 0.0016 0.0022 0.0003
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.0414 0.0408
Onchocerca volvulus 0.0259 0.1555 0.1623
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0021 0.0044
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0021 0.0015
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0252 0.0247
Loa Loa (eye worm) glutamate receptor 2 0.0157 0.0909 0.0945
Onchocerca volvulus 0.0078 0.0414 0.0427
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0068 0.0929
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.0064 0.015
Echinococcus multilocularis inositol monophosphatase 1 0.0115 0.0646 0.0641
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0177 0.1037 0.1032
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0288 0.0282
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0023 0.0064 0.0411
Loa Loa (eye worm) hypothetical protein 0.0145 0.0835 0.0868
Mycobacterium leprae conserved hypothetical protein 0.0075 0.039 0.5759
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0017
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0021 0.0311
Loa Loa (eye worm) RecQ helicase 0.0024 0.007 0.0067
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0012
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0023 0.0064 0.0411
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0378 0.08
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0534 0.0539
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0058 0.0286 0.028
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0125 0.0265
Brugia malayi 6-phosphofructokinase 0.0119 0.0674 0.0686
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.003 0.0064
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.0414 0.0408
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0108 0.0603 0.0598
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0646 0.1368
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0674 0.0668
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0674 0.7758
Brugia malayi mbt repeat family protein 0.0046 0.0212 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0603 0.0613
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0094 0.0479
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.039 0.0389
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0123 0.0758
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0414 0.0408
Brugia malayi larval opioid receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0016
Onchocerca volvulus 0.0016 0.0021 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0051
Onchocerca volvulus 0.005 0.0235 0.024
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0021 0.0044
Onchocerca volvulus 0.0041 0.018 0.0183
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.003 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0204 0.0193
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi Dopamine receptor protein 2 0.0078 0.0414 0.0413
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0414 0.0408
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0087
Onchocerca volvulus 0.0078 0.0414 0.0427
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0079 0.0422 0.0416
Loa Loa (eye worm) hypothetical protein 0.1525 0.9555 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni vesicular acetylcholine transporter 0.0428 0.2626 0.2733
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0064 0.0137
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0079 0.0422 0.0435
Brugia malayi hypothetical protein 0.0259 0.1555 0.1611
Brugia malayi intermediate filament protein 0.0055 0.0269 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0087
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0021 0.0311
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0031 0.0066
Loa Loa (eye worm) glutamate receptor 1 0.0157 0.0909 0.0945
Loa Loa (eye worm) norepinephrine transporter 0.1525 0.9555 1
Schistosoma mansoni myosin xvIII 0.0078 0.0414 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Brugia malayi hypothetical protein 0.0476 0.293 0.3052
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Echinococcus multilocularis allatostatin A receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0017
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0031 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi G-protein coupled receptor 0.0078 0.0414 0.0413
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0674 1
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0022 0.0017
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.1011 0.1006
Brugia malayi metabotropic glutamate receptor type 2 0.0016 0.0022 0.0003
Toxoplasma gondii ABC1 family protein 0.0075 0.039 0.2412
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0058 0.0288 0.0282
Brugia malayi beta-lactamase 0.0075 0.039 0.0389
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.1011 0.1006
Schistosoma mansoni lamin 0.0055 0.0269 0.0262
Schistosoma mansoni hypothetical protein 0.0078 0.0414 0.0413
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.039 0.5795
Mycobacterium leprae Probable lipase LipE 0.0075 0.039 0.5759
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0021 0.0044
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.0414 0.0408
Entamoeba histolytica hypothetical protein, conserved 0.0149 0.086 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0023 0.0064 0.0411
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.003 0.0064
Echinococcus multilocularis nAChR subunit 0.0058 0.0288 0.0282
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0058 0.0288 0.0282
Onchocerca volvulus 0.0078 0.0414 0.0427
Brugia malayi hypothetical protein 0.0176 0.1033 0.1063
Toxoplasma gondii hypothetical protein 0.0259 0.1555 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0068 0.0452
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.2928 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0088 0.0082
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0115 0.0646 0.4077
Loa Loa (eye worm) serotonin transporter b 0.1525 0.9555 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.0414 0.0427
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.1507 0.156
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0064 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.0064 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0252 0.0247
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0359 0.037
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0378 0.08
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Onchocerca volvulus 0.0046 0.0212 0.0216
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0064 0.0059
Leishmania major protein kinase, putative 0.0019 0.004 0.0085
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0674 0.1427
Echinococcus multilocularis glutamate receptor 2 0.0173 0.1011 0.1006
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Echinococcus multilocularis sodium and chloride dependent glycine 0.0259 0.1555 0.155
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Onchocerca volvulus 0.0041 0.018 0.0183
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0414 0.0408
Plasmodium vivax hypothetical protein, conserved 0.0075 0.039 0.2408
Onchocerca volvulus 0.0016 0.0022 0.0017
Echinococcus granulosus glutamate receptor NMDA 0.0084 0.045 0.0444
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0058 0.0286 0.028
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.005 0.0235 0.0226
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0094 0.0479
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0123 0.0667
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0021 0.0044
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.0414 0.0413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0125 0.0125
Echinococcus multilocularis 0.0023 0.0064 0.0059
Schistosoma mansoni hypothetical protein 0.0023 0.0064 0.0047
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0422 0.0416
Brugia malayi vesicular acetylcholine transporter unc-17 0.0428 0.2626 0.2733
Schistosoma mansoni lipoxygenase 0.0184 0.1085 0.1117
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) glutamate receptor 0.0016 0.0022 0.0017
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0115 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Schistosoma mansoni glutamate receptor AMPA 0.0157 0.0909 0.0933
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.1525 0.9555 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.0414 0.0413
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0094 0.02
Brugia malayi ERG2 and Sigma1 receptor like protein 0.076 0.4722 0.4932
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1611
Plasmodium falciparum amino acid transporter, putative 0.0259 0.1555 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0023 0.0064 0.0411
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0078 0.0414 0.0413
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.018 0.0175
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.005 0.0235 0.0229
Echinococcus granulosus lamin dm0 0.0055 0.0269 0.0263
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0023 0.0064 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0006 0.0012
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0064 0.0137
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.003 0.0062
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0414 0.0408
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.003 0.0064
Echinococcus multilocularis serotonin receptor 0.0078 0.0414 0.0408
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.039 0.1271
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0021 0.0044
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0064 0.0137
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.0012
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0212 0.0216
Echinococcus granulosus sphingosine kinase 1 0.0149 0.086 0.0854
Echinococcus multilocularis vesicular acetylcholine transporter 0.0428 0.2626 0.2621
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0252 0.0247
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0414 0.0413
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0177 0.1037 0.1032
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0021 0.0044
Onchocerca volvulus 0.0023 0.0068 0.0065
Brugia malayi Dopamine receptor 0.0078 0.0414 0.0413
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0021 0.0044
Echinococcus granulosus muscleblind protein 0.0145 0.0835 0.0829
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.005 0.0235 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0021 0.0002
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.003 0.0025
Schistosoma mansoni lamin 0.0055 0.0269 0.0262
Echinococcus multilocularis sodium and chloride dependent glycine 0.0259 0.1555 0.155
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0674 0.7837
Echinococcus granulosus microtubule associated protein 2 0.1465 0.9175 0.9175
Echinococcus granulosus glutamate receptor 2 0.0173 0.1011 0.1006
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0021 0.0015
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Schistosoma mansoni neurotransmitter gated ion channel 0.0058 0.0288 0.0282
Onchocerca volvulus 0.0055 0.0269 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0023 0.0064 0.0411
Echinococcus multilocularis sphingosine kinase 1 0.0149 0.086 0.0854
Loa Loa (eye worm) RNA binding protein 0.007 0.0359 0.037
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0259 0.1555 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0021 0.0311
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.0414 0.0408
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Brugia malayi 6-phosphofructokinase 0.0119 0.0674 0.0686
Onchocerca volvulus 0.0078 0.0414 0.0427
Leishmania major hypothetical protein, conserved 0.0016 0.0021 0.0044
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0064
Schistosoma mansoni cript-related 0.0016 0.0021 0.0002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0259 0.1555 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0674 1
Mycobacterium leprae putative cytochrome p450 0.0023 0.0064 0.0878
Brugia malayi Protein kinase domain containing protein 0.0016 0.0019 0.0000000060647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Schistosoma mansoni hypothetical protein 0.0079 0.0422 0.0422
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0259 0.1555 0.1611
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0177 0.1037 0.1032
Schistosoma mansoni cytochrome P450 0.0023 0.0064 0.0047
Schistosoma mansoni nocturnin 0.0016 0.0021 0.0002
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0123 0.0758
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0184 0.1085 0.108
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0422 0.0436
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.0064 0.015
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0414 0.0408
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.0414 0.0413
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.0414 0.0408
Schistosoma mansoni sodium/chloride dependent transporter 0.1525 0.9555 1
Brugia malayi Muscleblind-like protein 0.0145 0.0835 0.0855
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0019 0.0014
Schistosoma mansoni tyrosine kinase 0.0016 0.0022 0.0003
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.039 0.4342
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0414 0.0413
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0014
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.018 0.0175
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0038 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0414 0.0413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0378 0.0376
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0674 0.0685
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0212 0.0206
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.018 0.0182
Onchocerca volvulus 0.0075 0.039 0.0403
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0674 0.1427
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Onchocerca volvulus 0.0078 0.0414 0.0427
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0068 0.0452
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0065
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0259 0.1555 0.155
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0064 0.0137
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.0064 0.015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0021 0.0044
Mycobacterium ulcerans hypothetical protein 0.0149 0.086 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.0414 0.0427
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0176 0.1033 0.1076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0414 0.0413
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0079 0.0422 0.0893
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Onchocerca volvulus 0.0055 0.0269 0.0276
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.003 0.0064
Onchocerca volvulus 0.0075 0.039 0.0403
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.039 0.1271
Brugia malayi neuropeptide F receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus single minded 2 0.0043 0.0189 0.0183
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.003 0.0064
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0259 0.1555 0.1611
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.003 0.0354
Onchocerca volvulus 0.0058 0.0288 0.0296
Loa Loa (eye worm) hypothetical protein 0.076 0.4722 0.4939
Onchocerca volvulus 0.0259 0.1555 0.1623
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0021 0.0244
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.005 0.0235 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0452
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.039 0.5795
Schistosoma mansoni nAChR subunit 0.005 0.0235 0.0226
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0021 0.0311
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0378 0.0389
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0603 0.0613
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0006 0.0012
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.005 0.0235 0.024
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0378 0.08
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.018 0.1039
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0021 0.0244
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.039 0.0403
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0021 0.0015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0414 0.0408
Brugia malayi Inositol-1 0.0115 0.0646 0.0657
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.039 0.1271
Onchocerca volvulus 0.0078 0.0414 0.0427
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0006 0.0012
Echinococcus granulosus glutamate receptor subunit protein glur 0.0058 0.0286 0.028
Loa Loa (eye worm) hypothetical protein 0.0145 0.0835 0.0868
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1623
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0108 0.0603 0.0598
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0021 0.0016
Onchocerca volvulus 0.0078 0.0414 0.0427
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0058 0.0286 0.028
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0125 0.0265
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.0064 0.015
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0079 0.0422 0.0893
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0123 0.0667
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.0414 0.0413
Echinococcus multilocularis synaptic vesicular amine transporter 0.0204 0.1207 0.1202
Leishmania major hypothetical protein, conserved 0.0016 0.0021 0.0044
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0107 0.0106
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0414 0.0408
Echinococcus granulosus glutamate receptor 2 0.0115 0.0645 0.064
Schistosoma mansoni hypothetical protein 0.0041 0.018 0.0169
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0422 0.0422
Leishmania major hypothetical protein, conserved 0.0075 0.039 0.0827
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0378 0.08
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Brugia malayi hypothetical protein 0.0041 0.018 0.0169
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.003 0.0159
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.007 0.1041
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.003 0.0033
Leishmania major C-8 sterol isomerase-like protein 0.076 0.4722 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.0414 0.0408
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0125 0.0265
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0108 0.0603 0.0598
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0428 0.2626 0.2743
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0414 0.0408
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0422 0.2611
Echinococcus granulosus neuropeptide receptor 0.0078 0.0414 0.0408
Onchocerca volvulus 0.0078 0.0414 0.0427
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0422 0.6258
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0068 0.0929
Echinococcus multilocularis orexin receptor type 2 0.0078 0.0414 0.0408
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0165 0.0153
Toxoplasma gondii hypothetical protein 0.0259 0.1555 1
Loa Loa (eye worm) TAR-binding protein 0.007 0.0359 0.037
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0108 0.0603 0.0626
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0064 0.0137
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0259 0.1555 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0088 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0103 0.057 0.1889
Trichomonas vaginalis inositol monophosphatase, putative 0.0115 0.0646 0.959
Echinococcus granulosus tar DNA binding protein 0.007 0.0359 0.0353
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0252 0.0244
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0021 0.0244
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.018 0.0175
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0015
Echinococcus multilocularis serotonin transporter 0.1525 0.9555 0.9555
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0016 0.0022 0.0016
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0674 0.0686
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.018 0.0174
Echinococcus multilocularis neuropeptide s receptor 0.0078 0.0414 0.0408
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.003 0.0025
Schistosoma mansoni hypothetical protein 0.0172 0.1005 0.1033
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.0414 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0023 0.0064 0.0411
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi Cation transporter family protein 0.0253 0.152 0.1574
Brugia malayi hypothetical protein 0.0041 0.018 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0422 0.2611
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.0414 0.0413
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.039 0.4342
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0331 0.2009 0.2098
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0108 0.0603 0.0613
Onchocerca volvulus 0.0075 0.039 0.0403
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.0414 0.0408
Echinococcus granulosus glutamate NMDA receptor subunit 0.0333 0.2022 0.2017
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0184 0.1085 0.108
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0058 0.0286 0.028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0269 0.0276
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.0414 0.0408
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0072 0.0066
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0646 0.959
Echinococcus granulosus Ankyrin 0.0016 0.002 0.0014
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.0552 0.0546
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1586 0.9943 0.9943
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0017
Echinococcus granulosus metabotropic glutamate receptor 5 0.0016 0.0022 0.0016
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0125 0.0125
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0019 0.0014
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0204 0.1207 0.1258
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0835 0.0829
Echinococcus granulosus neuropeptide receptor 0.0227 0.1353 0.1348
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0378 0.0372
Echinococcus granulosus hypothetical protein 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0021 0.0015
Brugia malayi cytochrome P450 0.0023 0.0064 0.0047
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.0414 0.0413
Schistosoma mansoni protein kinase 0.0016 0.0022 0.0003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0603 0.0613
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0072 0.0152
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0006 0.0087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0068 0.0162
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0259 0.1555 0.155
Echinococcus granulosus serotonin receptor 0.0078 0.0414 0.0408
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0031 0.0066
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.0414 0.0413
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.0414 0.0408
Brugia malayi TAR-binding protein 0.007 0.0359 0.0356
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0414 0.0427
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0183
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.008
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0288 0.0282
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.003 0.0026
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.005 0.0235 0.0226
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0163 0.2414
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0259 0.1555 0.1611
Schistosoma mansoni neurotransmitter gated ion channel 0.005 0.0235 0.0226
Loa Loa (eye worm) hypoxia-induced factor 1 0.0163 0.0947 0.0985
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0016 0.0022 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0079 0.0422 0.0893
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0674 0.0699
Onchocerca volvulus 0.0078 0.0414 0.0427
Leishmania major cytochrome p450-like protein 0.0033 0.0125 0.0265
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0259 0.1555 0.155
Schistosoma mansoni hypothetical protein 0.0078 0.0414 0.0413
Schistosoma mansoni neuropeptide receptor 0.0078 0.0414 0.0413
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0422 0.0416
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0288 0.0282
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0378 0.0376
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0252 0.0244
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.003 0.0064
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0414 0.0408
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0023 0.0064 0.0411
Schistosoma mansoni vesicular amine transporter 0.0204 0.1207 0.1246
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0259 0.1555 0.1611
Echinococcus granulosus vesicular acetylcholine transporter 0.0428 0.2626 0.2621
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0422 0.6258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.0012
Schistosoma mansoni sphingoid long chain base kinase 0.0149 0.086 0.0881
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Leishmania major protein kinase, putative 0.0014 0.0006 0.0012
Brugia malayi RE15519p 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0021 0.0244
Loa Loa (eye worm) hypothetical protein 0.0995 0.6206 0.6493
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.067 0.0695
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0646 0.1368
Schistosoma mansoni microtubule-associated protein tau 0.1465 0.9175 0.9602
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0674 0.0686
Brugia malayi Doublecortin family protein 0.0041 0.018 0.0169
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0031 0.0025
Echinococcus multilocularis tar DNA binding protein 0.007 0.0359 0.0353
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.0064 0.015
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.039 0.0385
Echinococcus multilocularis bloom syndrome protein 0.0024 0.007 0.0064
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0023 0.0064 0.0411
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0115 0.0646 0.7424
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0108 0.0603 0.0598
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0674 0.2246
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Brugia malayi Serotonin receptor 0.0078 0.0414 0.0413
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0251 0.0243
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0428 0.2626 0.2743
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0064
Echinococcus multilocularis serotonin receptor 0.0078 0.0414 0.0408
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0165 0.0159
Loa Loa (eye worm) hypothetical protein 0.0388 0.2374 0.248
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0031 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.0064 0.015
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0064 0.0289
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0646 0.1368
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0177 0.1037 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0072 0.1065
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0177 0.1037 0.1032
Echinococcus granulosus g protein coupled receptor 0.0078 0.0414 0.0408
Echinococcus granulosus metabotropic glutamate receptor 2 0.0016 0.0022 0.0016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0414 0.0413
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Schistosoma mansoni ap endonuclease 0.0079 0.0422 0.0422
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0674 1
Echinococcus granulosus fmrfamide receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.003 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni hypothetical protein 0.0079 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0414 0.0408
Onchocerca volvulus 0.0108 0.0603 0.0626
Brugia malayi Cation transporter family protein 0.0108 0.0603 0.0613
Echinococcus granulosus nmda type glutamate receptor 0.01 0.0552 0.0546
Echinococcus granulosus death domain containing protein 0.0016 0.0019 0.0013
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0021 0.0003
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0021 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0108 0.0603 0.0613
Schistosoma mansoni ap endonuclease 0.0079 0.0422 0.0422
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0359 0.0356
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0019 0.0013
Brugia malayi Glutamate receptor 1 precursor 0.0157 0.0909 0.0933
Entamoeba histolytica hypothetical protein 0.0024 0.0072 0.0835
Trypanosoma cruzi extracellular receptor, putative 0.0016 0.0022 0.0046
Onchocerca volvulus 0.0108 0.0603 0.0626
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0021 0.0311
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Mycobacterium ulcerans lipase LipD 0.0075 0.039 0.4342
Brugia malayi MH2 domain containing protein 0.0119 0.067 0.0682
Onchocerca volvulus 0.0078 0.0414 0.0427
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0068 0.0452
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0079 0.0422 1
Schistosoma mansoni glutamate receptor NMDA 0.0333 0.2022 0.21
Loa Loa (eye worm) hypothetical protein 0.0995 0.6206 0.6493
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0212 0.0202
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0107 0.0092
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.0064 0.015
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0108 0.0603 0.0626
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0023 0.0064 0.0411
Onchocerca volvulus 0.0078 0.0414 0.0427
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0006 0.0087
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.0414 0.0427
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0244
Echinococcus multilocularis synaptojanin 1 0.0016 0.0021 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Mycobacterium ulcerans beta-lactamase 0.0075 0.039 0.4342
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.008
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Schistosoma mansoni hypothetical protein 0.1054 0.6582 0.6882
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0235 0.0226
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0204 0.0193
Brugia malayi Death domain containing protein 0.0016 0.0019 0.0000000060647
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0123 0.1831
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0031 0.0025
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0023 0.0064 0.0411
Schistosoma mansoni sphingosine kinase A B 0.0149 0.086 0.0881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Onchocerca volvulus 0.0097 0.0534 0.0553
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0017 0.0027 0.0057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0031 0.0066
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.1011 0.1006
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0072 0.0066
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.0414 0.0408
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.003 0.0064
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.018 0.0174
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0046 0.0212 0.0216
Leishmania major pantothenate kinase subunit, putative 0.0017 0.0027 0.0057
Onchocerca volvulus 0.0078 0.0414 0.0427
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0094 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Mycobacterium ulcerans hypothetical protein 0.0023 0.0068 0.0452
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni inositol monophosphatase 0.0115 0.0646 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0108 0.0603 0.0598
Brugia malayi GnHR receptor homolog 0.0078 0.0414 0.0413
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0414 0.0408
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0108 0.0603 0.0626
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1595 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.0012
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0259 0.1555 0.155
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0414 0.0413
Echinococcus granulosus glycine receptor subunit beta 0.0108 0.0603 0.0598
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0021 0.0015
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.007 0.0053
Brugia malayi Cation transporter family protein 0.0108 0.0603 0.0613
Loa Loa (eye worm) GABA receptor subunit 0.0058 0.0288 0.0296
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.003 0.0354
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0414 0.0408
Brugia malayi beta-lactamase family protein 0.0075 0.039 0.0389
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0079 0.0422 0.0416
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.018 0.0175
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0259 0.1555 0.155
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0414 0.0408
Echinococcus granulosus tyrosine kinase 0.0016 0.0022 0.0016
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.0064 0.015
Echinococcus multilocularis nmda type glutamate receptor 0.0142 0.0816 0.081
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.1011 0.1006
Echinococcus granulosus nAChR subunit 0.0058 0.0288 0.0282
Onchocerca volvulus 0.005 0.0235 0.024
Schistosoma mansoni opsin-like receptor 0.0078 0.0414 0.0413
Onchocerca volvulus 0.0078 0.0414 0.0427
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0031 0.0066
Echinococcus granulosus bloom syndrome protein 0.0024 0.007 0.0064
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0269 0.0262
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0006 0.0087
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0051
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0414 0.0408
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0108 0.0603 0.0613
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.039 0.5795
Echinococcus granulosus geminin 0.1054 0.6582 0.658
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0253 0.152 0.1574
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0087
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0058 0.0286 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.0414 0.0413
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0108 0.0603 0.0626
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0674 0.0668
Echinococcus granulosus allatostatin A receptor 0.0078 0.0414 0.0408
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0079 0.0422 0.4904
Echinococcus granulosus nAChR subunit 0.0108 0.0603 0.0598
Brugia malayi ORL1-like opioid receptor 0.0078 0.0414 0.0413
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0021 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.0144
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0019 0.0013
Echinococcus granulosus serotonin transporter 0.1525 0.9555 0.9555
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) doublecortin family protein 0.0041 0.018 0.0183
Loa Loa (eye worm) hypothetical protein 0.1525 0.9555 1
Schistosoma mansoni tyrosine kinase 0.0016 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Echinococcus multilocularis receptor type guanylyl cyclase 0.0016 0.0022 0.0016
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Schistosoma mansoni synaptojanin 0.0016 0.0021 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0674 1
Brugia malayi hypothetical protein 0.0018 0.0032 0.0014
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Schistosoma mansoni sodium/chloride dependent transporter 0.0259 0.1555 0.1611
Schistosoma mansoni lipoxygenase 0.011 0.0616 0.0625
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0031 0.0025
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.003 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.0064 0.015
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0414 0.0427
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.0144
Mycobacterium tuberculosis Conserved protein 0.0075 0.039 0.1271
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.293 0.2926
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0022 0.0003
Echinococcus multilocularis glutamate receptor 2 0.0115 0.0645 0.064
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0108 0.0603 0.0613
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0031 0.0071
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0022 0.0017
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Schistosoma mansoni biogenic amine receptor 0.0078 0.0414 0.0413
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.0064 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0031 0.0035
Mycobacterium tuberculosis Conserved protein 0.0149 0.086 0.2885
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0016 0.0022 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0378 0.0372
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0075 0.039 0.0403
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.0414 0.0408
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0123 0.2555
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0064 0.0878
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0414 0.0408
Schistosoma mansoni glutamate receptor NMDA 0.0257 0.1541 0.1596
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.0064 0.015
Brugia malayi G protein-coupled receptor 0.0078 0.0414 0.0413
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0072 0.0336
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0065
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0072 0.0055
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0103 0.057 0.8446
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0177 0.1037 0.1032
Schistosoma mansoni acetylcholine receptor-related 0.005 0.0235 0.0226
Schistosoma mansoni adenoreceptor 0.0078 0.0414 0.0413
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0031 0.0066
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0019 0.0000000060647
Schistosoma mansoni opsin-like receptor 0.0078 0.0414 0.0413
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Loa Loa (eye worm) ACC-1 protein 0.0108 0.0603 0.0626
Entamoeba histolytica hypothetical protein 0.0058 0.0288 0.3351
Echinococcus multilocularis lamin 0.0055 0.0269 0.0263
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.1507 0.1572
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0021 0.0015
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0125 0.1144
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0212 0.0206
Echinococcus granulosus g protein coupled receptor 0.0078 0.0414 0.0408
Schistosoma mansoni acetylcholine receptor subunit beta 0.005 0.0235 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.0414 0.0427
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.0414 0.0408
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0023 0.0064 0.0411
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0012
Schistosoma mansoni inositol monophosphatase 0.0115 0.0646 0.0657
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0414 0.0408
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.0414 0.0408
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0021 0.0044
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.293 0.2926
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.005 0.0235 0.0229
Loa Loa (eye worm) hypothetical protein 0.0177 0.1037 0.108
Schistosoma mansoni hypothetical protein 0.0079 0.0422 0.0422
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.0012
Schistosoma mansoni glutamate receptor kainate 0.0157 0.0909 0.0933
Brugia malayi Guanylyl cyclase protein 23 0.0016 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0006 0.0012
Echinococcus multilocularis lamin dm0 0.0055 0.0269 0.0263
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Schistosoma mansoni tar DNA-binding protein 0.007 0.0359 0.0356
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Trypanosoma cruzi C-8 sterol isomerase, putative 0.076 0.4722 1
Onchocerca volvulus 0.0058 0.0288 0.0296
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0065
Brugia malayi isocitrate dehydrogenase 0.0018 0.0031 0.0012
Loa Loa (eye worm) hypothetical protein 0.0054 0.0263 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0414 0.0408
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Loa Loa (eye worm) solute carrier family 6 member 4 0.1525 0.9555 1
Echinococcus multilocularis neuropeptide receptor A26 0.0078 0.0414 0.0408
Brugia malayi Metabotropic glutamate receptor precursor. 0.0016 0.0022 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0414 0.0408
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.067 0.0695
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Echinococcus granulosus sodium and chloride dependent glycine 0.0259 0.1555 0.155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.024
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0674 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0021 0.0311
Echinococcus multilocularis microtubule associated protein 2 0.1465 0.9175 0.9175
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0414 0.0408
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0163 0.2414
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.039 0.1271
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Brugia malayi sulfakinin receptor protein 0.0078 0.0414 0.0413
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.003 0.0064
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0021 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0123 0.1831
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Onchocerca volvulus 0.0016 0.0022 0.0017
Echinococcus multilocularis GPCR, family 2 0.0079 0.0422 0.0416
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0173 0.1011 0.1006
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Loa Loa (eye worm) hypothetical protein 0.0259 0.1555 0.1623
Leishmania major hypothetical protein, conserved 0.0028 0.0094 0.02
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.0414 0.0408
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0021 0.0016
Echinococcus multilocularis NMDA receptor 0.0058 0.0286 0.028
Echinococcus granulosus neuropeptide s receptor 0.0078 0.0414 0.0408
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0021 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0414 0.0413
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.003 0.0064
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0422 0.0422
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0051
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0253 0.152 0.1574
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0031 0.0066
Brugia malayi hypothetical protein 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Echinococcus granulosus somatostatin receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) inositol-1 0.0115 0.0646 0.067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0235 0.0226
Brugia malayi Dopamine receptor protein 1 0.0078 0.0414 0.0413
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0414 0.0408
Brugia malayi Serotonin receptor 0.0078 0.0414 0.0413
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0603 0.0613
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.005 0.0235 0.0229
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0017
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0023 0.0064 0.0411
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0031 0.0071
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.0414 0.0427
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0021 0.0002
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0259 0.1555 0.155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0108 0.0603 0.0598
Echinococcus multilocularis sex peptide receptor 0.0078 0.0414 0.0408
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0016 0.0022 0.0017
Schistosoma mansoni rab6-interacting 0.0041 0.018 0.0169
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.1507 0.156
Schistosoma mansoni amine GPCR 0.0078 0.0414 0.0413
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.003 0.0064
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.0149 0.086 0.0894
Brugia malayi CCR4 0.0016 0.0021 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.0064 0.015
Onchocerca volvulus 0.0108 0.0603 0.0626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0072 0.0055
Mycobacterium tuberculosis Conserved protein 0.0075 0.039 0.1271
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Schistosoma mansoni biogenic amine receptor 0.0078 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0078 0.0414 0.0427
Trichomonas vaginalis esterase, putative 0.0075 0.039 0.5795
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.005 0.0107
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.0296
Echinococcus granulosus GPCR family 2 0.0079 0.0422 0.0416
Plasmodium vivax amine transporter, putative 0.0259 0.1555 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0603 0.0613
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0052 0.0201
Echinococcus multilocularis G protein coupled receptor 139 0.0227 0.1353 0.1348
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0603 0.0598
Echinococcus granulosus sex peptide receptor 0.0078 0.0414 0.0408
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0021 0.0044
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1173 0.1167
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.039 0.0385
Brugia malayi phosphofructokinase 0.0119 0.0674 0.0686
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0012
Onchocerca volvulus 0.0078 0.0414 0.0427
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0259 0.1555 0.1611
Echinococcus multilocularis neuropeptide receptor 0.0227 0.1353 0.1348
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0068 0.079
Echinococcus granulosus inositol monophosphatase 1 0.0115 0.0646 0.0641
Echinococcus multilocularis tyrosine kinase 0.0016 0.0022 0.0016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0079 0.0422 0.4717
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.002 0.0001
Echinococcus granulosus synaptojanin 1 0.0016 0.0021 0.0015
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.0414 0.0408
Leishmania major cytochrome p450-like protein 0.0023 0.0064 0.0137
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0252 0.0258
Brugia malayi hypothetical protein 0.005 0.0235 0.0226
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0378 0.4392
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0123 0.0667
Brugia malayi follicle stimulating hormone receptor 0.0331 0.2009 0.2087
Brugia malayi Abnormal catecholamine distribution protein 1 0.0204 0.1207 0.1246
Schistosoma mansoni nAChR subunit 0.0108 0.0603 0.0613
Echinococcus granulosus RUN 0.0041 0.018 0.0175
Onchocerca volvulus 0.0078 0.0414 0.0427
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0212 0.0206
Onchocerca volvulus 0.0253 0.152 0.1586
Schistosoma mansoni hypothetical protein 0.0097 0.0534 0.0539
Echinococcus granulosus g protein coupled receptor 0.0078 0.0414 0.0408
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0031 0.0025
Brugia malayi Glutamate receptor 2 precursor 0.0157 0.0909 0.0933
Brugia malayi mbt repeat family protein 0.0046 0.0212 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0451
Loa Loa (eye worm) hypothetical protein 0.0251 0.1507 0.1572
Loa Loa (eye worm) hypothetical protein 0.0108 0.0603 0.0626

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Activation of human P-gp ATPase in human Caco2 cells at 100 uM ChEMBL. 18276145
Activity (binding) 0 Activation of human P-gp ATPase in human Caco2 cells at 100 uM ChEMBL. 18276145
EC50 (binding) = 0.8 uM Inhibition of human P-gp mediated [3H]vinblastine transport activity in human Caco2 cells ChEMBL. 18276145
Papp (ADMET) = 216 nm/s Apparent permeability from apical to basoleteral side of human Caco2 cell membrane ChEMBL. 18276145
Papp (ADMET) = 216 nm/s Apparent permeability from apical to basoleteral side of human Caco2 cell membrane ChEMBL. 18276145
Papp (ADMET) = 1797 nm/s Apparent permeability from basolateral to apical side of human Caco2 cell membrane ChEMBL. 18276145
Papp (ADMET) = 1797 nm/s Apparent permeability from basolateral to apical side of human Caco2 cell membrane ChEMBL. 18276145
Ratio (ADMET) = 8.3 Ratio of permeability from apical to basoleteral over basoleteral to apical side of human Caco2 cell membrane ChEMBL. 18276145

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.