Detailed information for compound 612169

Basic information

Technical information
  • TDR Targets ID: 612169
  • Name: 1-(5-chloro-2-methoxyphenyl)-4-(1-prop-2-enyl benzimidazol-2-yl)pyrrolidin-2-one
  • MW: 381.855 | Formula: C21H20ClN3O2
  • H donors: 0 H acceptors: 2 LogP: 3.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(nc2c1cccc2)C1CN(C(=O)C1)c1cc(Cl)ccc1OC
  • InChi: 1S/C21H20ClN3O2/c1-3-10-24-17-7-5-4-6-16(17)23-21(24)14-11-20(26)25(13-14)18-12-15(22)8-9-19(18)27-2/h3-9,12,14H,1,10-11,13H2,2H3
  • InChiKey: JJEPYUQVXQSZKZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1-allylbenzimidazol-2-yl)-1-(5-chloro-2-methoxy-phenyl)pyrrolidin-2-one
  • 4-(1-allyl-2-benzimidazolyl)-1-(5-chloro-2-methoxyphenyl)-2-pyrrolidinone
  • 4-(1-allylbenzimidazol-2-yl)-1-(5-chloro-2-methoxy-phenyl)-2-pyrrolidone
  • 1-(5-chloro-2-methoxy-phenyl)-4-(1-prop-2-enylbenzimidazol-2-yl)pyrrolidin-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0043 0.0062 0.02
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0037 0.0118
Loa Loa (eye worm) hypothetical protein 0.0059 0.0099 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.004 0.0054 0.0174
Mycobacterium ulcerans beta-lactamase 0.0216 0.0457 0.6806
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.027
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.008 0.008
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0017 0.0003 0.0003
Mycobacterium ulcerans L-lysine aminotransferase 0.0043 0.0062 0.093
Brugia malayi MBOAT family protein 0.0378 0.0828 0.0828
Loa Loa (eye worm) cytochrome P450 0.004 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0045 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0378 0.0828 0.3831
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0003 0.003
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.004 0.0054 0.0174
Loa Loa (eye worm) hypothetical protein 0.0216 0.0457 0.0455
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.004 0.0054 0.0174
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.023 0.023
Mycobacterium ulcerans esterase/lipase LipP 0.0216 0.0457 0.6806
Schistosoma mansoni thyroid hormone receptor 0.0051 0.008 0.008
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0378 0.0828 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0322 0.0701 0.0701
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.013
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.004 0.0054 0.0656
Schistosoma mansoni zinc finger protein 0.0024 0.0018 0.0018
Brugia malayi MAP kinase sur-1 0.0156 0.0321 0.0321
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0043 0.0062 0.02
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0845 0.1896 0.1894
Trichomonas vaginalis D-aminoacylase, putative 0.0216 0.0457 0.2114
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0161 0.0747
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.008 0.008
Mycobacterium tuberculosis Probable reductase 0.0105 0.0203 0.0653
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0003 0.003
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0045 0.0209
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.031 0.0672 0.2155
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.008 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.019 0.0398 0.4785
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0378 0.0828 0.0828
Mycobacterium ulcerans hypothetical protein 0.0156 0.032 0.4772
Schistosoma mansoni thyroid hormone receptor 0.0051 0.008 0.008
Echinococcus granulosus o acyltransferase membrane bound domain 0.0378 0.0828 0.0828
Echinococcus multilocularis mitogen activated protein kinase 3 0.0156 0.0321 0.0321
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0018 0.0016
Schistosoma mansoni ran 0.0021 0.0011 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.019 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0123 0.0246 0.0243
Schistosoma mansoni hypothetical protein 0.0378 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Mycobacterium leprae Probable lipase LipE 0.0216 0.0457 0.6923
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0078
Schistosoma mansoni sterol O-acyltransferase 1 0.0378 0.0828 0.0828
Brugia malayi cytochrome P450 0.004 0.0054 0.0054
Trypanosoma cruzi glycerol uptake protein, putative 0.0378 0.0828 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0025
Trypanosoma cruzi GUP1, putative 0.0378 0.0828 1
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.008 0.0358
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0043 0.0062 0.093
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.0594 0.0594
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.0457 0.5518
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.008 0.008
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0378 0.0828 0.0828
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.008 0.0077
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0378 0.0828 0.0826
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.004 0.0054 0.0809
Mycobacterium leprae putative cytochrome p450 0.004 0.0054 0.0789
Trichomonas vaginalis D-aminoacylase, putative 0.0216 0.0457 0.2114
Brugia malayi RNA, U transporter 1 0.008 0.0146 0.0146
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0043 0.0062 0.0754
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0018 0.0018
Mycobacterium tuberculosis Conserved protein 0.0216 0.0457 0.1467
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0022
Brugia malayi nuclear receptor RXR 0.0027 0.0025 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.008 0.008
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0003 0.003
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0378 0.0828 1
Brugia malayi hypothetical protein 0.0033 0.0039 0.0039
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0034 0.0041 0.0041
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0378 0.0828 0.0828
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0003 0.0003
Plasmodium vivax glutathione reductase, putative 0.0046 0.0069 0.0829
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.004 0.0054 0.0174
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0118 0.0233 0.0233
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0059 0.071
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.0077
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0017 0.0003 0.0038
Brugia malayi beta-lactamase family protein 0.0216 0.0457 0.0457
Mycobacterium tuberculosis Probable aminotransferase 0.0304 0.0659 0.2115
Trypanosoma brucei unspecified product 0.0019 0.0006 0.0078
Echinococcus granulosus histone acetyltransferase KAT2B 0.0286 0.0618 0.0618
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.023 0.0738
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0045 0.0546
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.008 0.008
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0017 0.0003 0.003
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.004 0.0054 0.0809
Toxoplasma gondii histone lysine methyltransferase SET1 0.0235 0.05 0.6035
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.019 0.0398 0.0395
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0004
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.004 0.0054 0.0809
Brugia malayi Muscleblind-like protein 0.1208 0.2725 0.2725
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.008 0.008
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0304 0.0659 1
Trichomonas vaginalis transmembrane protein nessy, putative 0.0378 0.0828 0.3831
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0076 0.0076
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1379 0.3117 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.004 0.0054 0.0809
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0081 0.0974
Brugia malayi hypothetical protein 0.0468 0.1034 0.1034
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0203 0.0653
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.004 0.0054 0.0174
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.019 0.0398 0.4801
Trypanosoma cruzi glycerol uptake protein, putative 0.0378 0.0828 1
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0378 0.0828 0.0828
Loa Loa (eye worm) MBOAT family protein 0.0378 0.0828 0.0826
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0378 0.0828 0.0828
Schistosoma mansoni cpg binding protein 0.0124 0.0248 0.0248
Mycobacterium tuberculosis Conserved protein 0.0216 0.0457 0.1467
Brugia malayi MBOAT family protein 0.0378 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0049 0.0076 0.0074
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Leishmania major cytochrome p450-like protein 0.004 0.0054 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Loa Loa (eye worm) hhat protein 0.0378 0.0828 0.0826
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0378 0.0828 0.0828
Echinococcus granulosus ubiquitin specific protease 41 0.019 0.0398 0.0398
Onchocerca volvulus 0.0378 0.0828 0.3824
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0018 0.0073
Schistosoma mansoni hypothetical protein 0.1272 0.2871 0.2871
Leishmania major DNA polymerase eta, putative 0.0019 0.0006 0.0078
Onchocerca volvulus 0.0096 0.0182 0.0831
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0321 0.1486
Trichomonas vaginalis conserved hypothetical protein 0.0378 0.0828 0.3831
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.019 0.0398 0.0398
Echinococcus granulosus RUN 0.0059 0.0099 0.0099
Trichomonas vaginalis helicase, putative 0.0027 0.0025 0.0113
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0006
Brugia malayi MBOAT family protein 0.0378 0.0828 0.0828
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0017 0.0003 0.0003
Leishmania major trypanothione reductase 0.0046 0.0069 0.0829
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0016 0.0072
Brugia malayi ecdysteroid receptor 0.0051 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0018 0.0016
Echinococcus multilocularis snurportin 1 0.0299 0.0648 0.0648
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.004 0.0054 0.0174
Schistosoma mansoni ran 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.1208 0.2725 0.2723
Mycobacterium tuberculosis Conserved protein 0.0216 0.0457 0.1467
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0156 0.0321 0.3878
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0006 0.0048
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0081 0.0974
Onchocerca volvulus 0.0216 0.0457 0.2105
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0294 0.0636 0.0636
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Brugia malayi hypothetical protein 0.0024 0.0018 0.0018
Schistosoma mansoni eyes absent homolog 0.009 0.0169 0.0169
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0011 0.013
Mycobacterium leprae conserved hypothetical protein 0.0216 0.0457 0.6923
Trypanosoma cruzi cytochrome p450-like protein, putative 0.004 0.0054 0.0656
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0018 0.0018
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0051 0.0592
Brugia malayi MBOAT family protein 0.0378 0.0828 0.0828
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0378 0.0828 0.0828
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni inositol monophosphatase 0.0036 0.0045 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0051 0.062
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.019 0.0398 0.0398
Trypanosoma brucei glycerol uptake protein, putative 0.0378 0.0828 1
Brugia malayi Cytochrome P450 family protein 0.0058 0.0096 0.0096
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0018 0.0018
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0043 0.0062 0.02
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0378 0.0828 0.0828
Trypanosoma brucei trypanothione reductase 0.0046 0.0069 0.0829
Brugia malayi Thioredoxin reductase 0.0046 0.0069 0.0069
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0045 0.0546
Brugia malayi hypothetical protein 0.0059 0.0099 0.0099
Trichomonas vaginalis porcupine, putative 0.0378 0.0828 0.3831
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0025 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0321 0.1486
Echinococcus multilocularis neuropeptide receptor A26 0.0971 0.2185 0.2185
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.004 0.0054 0.0809
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0156 0.0321 0.3878
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0006 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0025 0.0022
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.004 0.0054 0.0809
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0216 0.0457 0.1467
Schistosoma mansoni importin beta-1 0.0028 0.0028 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.004 0.0054 0.0809
Trypanosoma brucei glycerol uptake protein, putative 0.0378 0.0828 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0276 0.0594 0.0594
Loa Loa (eye worm) CXXC zinc finger family protein 0.0118 0.0233 0.023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0299 0.0648 0.0648
Brugia malayi diacylglycerol acyltransferase 0.0378 0.0828 0.0828
Echinococcus granulosus microtubule associated protein 2 0.1379 0.3118 0.3118
Mycobacterium leprae Conserved hypothetical protein 0.004 0.0054 0.0789
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.004 0.0054 0.0174
Echinococcus granulosus FTZ F1 alpha 0.0051 0.008 0.008
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.004 0.0054 0.0809
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0156 0.0321 0.0319
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0051 0.1292
Trypanosoma cruzi glycerol uptake protein, putative 0.0378 0.0828 1
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0017 0.0003 0.0003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0025 0.0025
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.019 0.0398 0.0398
Schistosoma mansoni aldehyde dehydrogenase 0.031 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.0216 0.0457 0.0455
Leishmania major glycerol uptake protein, putative 0.0378 0.0828 1
Brugia malayi ecdysone receptor 0.0024 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Giardia lamblia DINP protein human, muc B family 0.0019 0.0006 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.008 0.008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0059 0.071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0025 0.0113
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0062 0.093
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0321 0.1486
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0096 0.1158
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.008 0.008
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.004 0.0054 0.0174
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0018 0.0018
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0017 0.0003 0.0038
Echinococcus granulosus tumor protein p63 0.0684 0.1528 0.1528
Leishmania major glycerol uptake protein, putative 0.0378 0.0828 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0006 0.003
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0378 0.0828 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.008 0.008
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0069 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.0077
Brugia malayi aldehyde dehydrogenase 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.01 0.0193 0.019
Leishmania major glycerol uptake protein, putative 0.0378 0.0828 1
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0003 0.003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0008
Brugia malayi follicle stimulating hormone receptor 0.0925 0.2078 0.2078
Mycobacterium ulcerans aldehyde dehydrogenase 0.031 0.0672 1
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0043 0.0062 0.0913
Mycobacterium tuberculosis Probable lipase LipD 0.0216 0.0457 0.1467
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.0077
Brugia malayi nuclear receptor RXR 0.0024 0.0018 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.032 0.1028
Echinococcus multilocularis tumor protein p63 0.0684 0.1528 0.1528
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.008 0.008
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0017 0.0003 0.0003
Schistosoma mansoni lipoxygenase 0.0233 0.0496 0.0496
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0017 0.0003 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0216 0.0457 0.1467
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0003 0.0003
Mycobacterium ulcerans hypothetical protein 0.0304 0.0659 0.9815
Brugia malayi Aldehyde dehydrogenase protein 4 0.0017 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0081 0.0974
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0016 0.0016
Toxoplasma gondii ABC1 family protein 0.0216 0.0457 0.5518
Loa Loa (eye worm) hypothetical protein 0.0378 0.0828 0.0826
Echinococcus granulosus ornithine aminotransferase 0.0043 0.0062 0.0062
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0099 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0017 0.0003 0.0038
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0018 0.0018
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0145 0.3644
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.004 0.0054 0.0174
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0018 0.0018
Toxoplasma gondii hypothetical protein 0.0378 0.0828 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0076 0.0074
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0017 0.0003 0.0404
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0378 0.0828 1
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0017 0.0003 0.003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0284 0.3431
Brugia malayi hypothetical protein 0.0027 0.0025 0.0025
Onchocerca volvulus 0.0123 0.0246 0.1126
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0378 0.0828 0.0828
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0051 0.062
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0161 0.1949
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0062 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Brugia malayi hypothetical protein 0.0051 0.0081 0.0081
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0233 0.0496 0.0496
Leishmania major cytochrome p450-like protein 0.004 0.0054 0.0656
Mycobacterium tuberculosis Probable lipase LipE 0.0216 0.0457 0.1467
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.031 0.0672 0.8108
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.019 0.0398 1
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.1208 0.2725 0.2723
Echinococcus granulosus neuropeptide s receptor 0.0971 0.2185 0.2185
Mycobacterium tuberculosis Probable hydrolase 0.0216 0.0457 0.1467
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Plasmodium falciparum glutathione reductase 0.0046 0.0069 0.0829
Schistosoma mansoni hypothetical protein 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0017 0.0003 0.0003
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0099 0.12
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0003 0.003
Echinococcus multilocularis zinc finger protein 0.4011 0.9135 0.9135
Schistosoma mansoni hypothetical protein 0.004 0.0054 0.0054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0045 0.0209
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.008 0.008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0648 0.0646
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0284 0.3431
Echinococcus granulosus muscleblind protein 0.1208 0.2725 0.2725
Brugia malayi glutathione reductase 0.0046 0.0069 0.0069
Onchocerca volvulus 0.0059 0.0099 0.0449
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0018 0.0073
Entamoeba histolytica hypothetical protein 0.0378 0.0828 1
Plasmodium vivax SET domain protein, putative 0.0123 0.0246 0.2967
Entamoeba histolytica hypothetical protein 0.0322 0.0701 0.8455
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0216 0.0457 0.0455
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0045 0.0517
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0378 0.0828 0.0826
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.008 0.0077
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.008 0.008
Onchocerca volvulus 0.0962 0.2162 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.013
Brugia malayi nuclear receptor NHR-88 0.0024 0.0018 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0276 0.0594 0.0591
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.008 0.0962
Onchocerca volvulus Huntingtin homolog 0.0126 0.0252 0.1153
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0069 0.022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.008 0.008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.008 0.008
Schistosoma mansoni survival motor neuron protein 0.0096 0.0182 0.0182
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.008 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.008 0.008
Echinococcus granulosus mixed lineage leukemia protein mll 0.0034 0.0041 0.0041
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0011
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0018 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.0594 0.0594
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0017 0.0003 0.0038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0006 0.0006
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0051 0.0765
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0081 0.0974
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0216 0.0457 0.0457
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0378 0.0828 0.0828
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.031 0.0672 0.0672
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0017 0.0003 0.0038
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.023 0.0738
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0006 0.0078
Loa Loa (eye worm) hypothetical protein 0.0216 0.0457 0.0455
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0059 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0018 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0078
Brugia malayi beta-lactamase family protein 0.0216 0.0457 0.0457
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0081 0.0974
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.008 0.008
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.004 0.0054 0.0174
Schistosoma mansoni ap endonuclease 0.0038 0.0051 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.008 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Giardia lamblia Alcohol dehydrogenase 0.0017 0.0003 0.0064
Entamoeba histolytica hypothetical protein 0.0322 0.0701 0.8455
Brugia malayi Hhat protein 0.0378 0.0828 0.0828
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0006
Echinococcus granulosus dnaJ subfamily B 0.1272 0.2871 0.2871
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.0096 0.1428
Brugia malayi hypothetical protein 0.0059 0.0099 0.0099
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0378 0.0828 0.0826
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.0641 0.774
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.008 0.008
Leishmania major glycerol uptake protein, putative 0.0378 0.0828 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.0077
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0018 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0216 0.0457 0.2114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.008 0.0077
Loa Loa (eye worm) hypothetical protein 0.009 0.0169 0.0166
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0378 0.0828 0.0828
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0003 0.0003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0123 0.0246 0.0246
Mycobacterium ulcerans acetylornithine aminotransferase 0.0043 0.0062 0.093
Trichomonas vaginalis D-aminoacylase, putative 0.0216 0.0457 0.2114
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0017 0.0003 0.0003
Brugia malayi hypothetical protein 0.009 0.0169 0.0169
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0051 0.0238
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0025 0.0113
Echinococcus multilocularis 0.004 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0216 0.0457 0.0455
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.004 0.0054 0.0809
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0017 0.0003 0.0008
Echinococcus granulosus mitogen activated protein kinase 3 0.0156 0.0321 0.0321
Leishmania major lanosterol 14-alpha-demethylase, putative 0.004 0.0054 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.004 0.0054 0.0174
Schistosoma mansoni polycystin 1-related 0.0059 0.0099 0.0099
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.008 0.008
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0006 0.0096
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.004 0.0054 0.0809
Onchocerca volvulus 0.0059 0.0099 0.0449
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0025 0.0113
Onchocerca volvulus 0.0024 0.0018 0.0073
Loa Loa (eye worm) MBOAT family protein 0.4389 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.0077
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0378 0.0828 0.0828
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.008 0.0358
Brugia malayi Pre-SET motif family protein 0.0123 0.0246 0.0246
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0045 0.0546
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0018 0.0018
Echinococcus multilocularis ubiquitin specific protease 41 0.019 0.0398 0.0398
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.019 0.0398 0.4801
Echinococcus multilocularis sterol O acyltransferase 1 0.0378 0.0828 0.0828
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0216 0.0457 0.6806
Treponema pallidum alginate O-acetylation protein (algI) 0.0378 0.0828 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0069 0.0066
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.004 0.0054 0.0809
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0017 0.0003 0.0008
Brugia malayi Importin beta-1 subunit 0.0028 0.0028 0.0028
Plasmodium falciparum ornithine aminotransferase 0.0043 0.0062 0.0754
Echinococcus multilocularis dnaJ subfamily B 0.1272 0.2871 0.2871
Echinococcus multilocularis survival motor neuron protein 1 0.0468 0.1034 0.1034
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.019 0.0398 0.1839
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0018 0.0018
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.031 0.0672 0.0672
Brugia malayi conserved hypotetical protein 0.0024 0.0018 0.0018
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0304 0.0659 0.2115
Echinococcus multilocularis cpg binding protein 0.0124 0.0248 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.008 0.008
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.008 0.008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0182 0.0182
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.004 0.0054 0.0809
Loa Loa (eye worm) MBOAT family protein 0.0378 0.0828 0.0826
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0051 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Schistosoma mansoni coup transcription factor 0.0051 0.008 0.008
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.019 0.0398 0.0398
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0051 0.8229
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.0246 0.0246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0246 0.0246
Toxoplasma gondii aldehyde dehydrogenase 0.031 0.0672 0.8108
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0017 0.0003 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.008 0.008
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0003 0.003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0051 0.062
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0043 0.0062 0.02
Schistosoma mansoni DNA polymerase eta 0.0019 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0025 0.0113
Loa Loa (eye worm) hypothetical protein 0.0378 0.0828 0.0826
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0378 0.0828 0.0828
Echinococcus granulosus sterol O acyltransferase 1 0.0378 0.0828 0.0828
Leishmania major hypothetical protein, conserved 0.0378 0.0828 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0378 0.0828 0.0828
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0017 0.0003 0.0012
Leishmania major importin beta-1 subunit, putative 0.0023 0.0016 0.0188
Entamoeba histolytica hypothetical protein, conserved 0.0378 0.0828 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0252 0.0249
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.0457 0.5518
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0018 0.0018
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0304 0.0659 0.3049
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.004 0.0054 0.0174
Echinococcus granulosus importin subunit beta 1 0.0028 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Treponema pallidum gamma-glutamyl phosphate reductase 0.0017 0.0003 0.003
Echinococcus multilocularis muscleblind protein 0.1208 0.2725 0.2725
Brugia malayi nuclear hormone receptor 0.0024 0.0018 0.0018
Brugia malayi nuclear receptor NHR-67 0.0024 0.0018 0.0018
Brugia malayi acetyltransferase, GNAT family protein 0.0294 0.0636 0.0636
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0045 0.0546
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.019 0.0398 0.1839
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Loa Loa (eye worm) histone methyltransferase 0.0041 0.0057 0.0054
Loa Loa (eye worm) CYP4Cod1 0.0058 0.0096 0.0093
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0925 0.2078 0.2076
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0003 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0216 0.0457 0.1467
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.008 0.0358
Schistosoma mansoni nuclear receptor 0.0024 0.0018 0.0018
Loa Loa (eye worm) DR-78 0.0024 0.0018 0.0016
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0156 0.0321 0.3878
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0018 0.0018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0051 0.0051
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.004 0.0054 0.0809
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0099 0.0099
Schistosoma mansoni zinc finger protein 0.4389 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0203 0.0653
Schistosoma mansoni hypothetical protein 0.0034 0.0041 0.0041
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0028 0.0334
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.019 0.0398 0.0398
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.4389 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.0641 0.774
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0006 0.003
Brugia malayi hypothetical protein 0.0126 0.0252 0.0252
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0099 0.0099
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0156 0.0321 0.3878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0594 0.0594
Brugia malayi hypothetical protein 0.0024 0.0018 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.004 0.0054 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.008 0.0077
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0203 0.0653
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0321 0.1486
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0016 0.0072
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0041 0.0057 0.0057
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0322 0.0701 0.0701
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.004 0.0054 0.0174
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0051 0.062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0594 0.0594
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.004 0.0054 0.0809
Echinococcus granulosus histone lysine methyltransferase setb 0.0123 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0468 0.1034 0.1032
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0006 0.0021
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0003 0.003
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0006 0.0006
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0062 0.0062
Brugia malayi Cytochrome P450 family protein 0.0058 0.0096 0.0096
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0156 0.0321 0.3878
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0045 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Mycobacterium ulcerans hypothetical protein 0.0216 0.0457 0.6806
Onchocerca volvulus Huntingtin homolog 0.0126 0.0252 0.1153
Echinococcus granulosus neuropeptide receptor A26 0.0971 0.2185 0.2185
Schistosoma mansoni cytochrome P450 0.004 0.0054 0.0054
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0062 0.093
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.023 0.3467
Leishmania major hypothetical protein, conserved 0.0216 0.0457 0.5518
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0017 0.0003 0.0008
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0003 0.003
Trypanosoma brucei protein kinase, putative 0.0156 0.0321 0.3878
Echinococcus multilocularis beta LACTamase domain containing family member 0.0216 0.0457 0.0457
Brugia malayi steroid hormone receptor 0.0051 0.008 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0322 0.0701 0.0701
Brugia malayi nuclear hormone receptor 0.0051 0.008 0.008
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.019 0.0398 0.4801
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0076 0.0076
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.004 0.0054 0.0809
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0203 0.0653
Entamoeba histolytica hypothetical protein 0.0322 0.0701 0.8455
Onchocerca volvulus 0.0118 0.0233 0.1065
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0017 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Loa Loa (eye worm) hypothetical protein 0.0126 0.0252 0.0249
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0156 0.0321 0.3878
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0081 0.0974
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.004 0.0054 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0378 0.0828 0.3831
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Leishmania major hypothetical protein, conserved 0.0051 0.0081 0.0974
Entamoeba histolytica Ran family GTPase 0.0021 0.0011 0.01
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0043 0.0062 0.0062
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0378 0.0828 1
Onchocerca volvulus 0.0051 0.008 0.0358
Brugia malayi Cytochrome P450 family protein 0.0156 0.032 0.032
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0011 0.0011
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0059 0.0099 0.0099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0051 0.062
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0069 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0022
Brugia malayi Pre-SET motif family protein 0.0845 0.1896 0.1896
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.008 0.008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0051 0.062
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0203 0.3059
Echinococcus granulosus zinc finger protein 0.4011 0.9135 0.9135
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.008 0.008
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0378 0.0828 0.0828
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.008 0.008
Schistosoma mansoni nuclear receptor 0.0024 0.0018 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0025 0.0113
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Loa Loa (eye worm) acetyltransferase 0.0294 0.0636 0.0634
Brugia malayi nuclear receptor NHR-88 0.0051 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0378 0.0828 0.0826
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0017 0.0003 0.0003
Onchocerca volvulus 0.0024 0.0018 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Onchocerca volvulus 0.01 0.0193 0.088
Schistosoma mansoni aldehyde dehydrogenase 0.031 0.0672 0.0672
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0022
Schistosoma mansoni rab6-interacting 0.0059 0.0099 0.0099
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2407 0.5468 0.5468
Echinococcus granulosus mitogen activated protein kinase 0.0156 0.0321 0.0321
Echinococcus granulosus snurportin 1 0.0299 0.0648 0.0648
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0003 0.0003
Plasmodium vivax importin-beta 2, putative 0.0028 0.0028 0.0334
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0233 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.009 0.0169 0.0166
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0099 0.12
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0018 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0041 0.0041
Schistosoma mansoni microtubule-associated protein tau 0.1379 0.3118 0.3118
Toxoplasma gondii cytochrome p450 superfamily protein 0.004 0.0054 0.0656
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.008 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0006 0.0096
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0216 0.0457 0.1467
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.019 0.0398 0.1839
Schistosoma mansoni rab6-interacting 0.0059 0.0099 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0216 0.0457 0.0457
Trypanosoma brucei hypothetical protein, conserved 0.0216 0.0457 0.5518
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0025 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0096 0.0093
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0156 0.0321 0.3878
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0145 0.175
Echinococcus multilocularis muscleblind protein 1 0.1208 0.2725 0.2725
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0051 0.062
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0018 0.0018
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0028 0.0334
Loa Loa (eye worm) beta-lactamase 0.0216 0.0457 0.0455
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0041 0.0041
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0025 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0216 0.0457 0.5518
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0051 0.0165
Brugia malayi beta-lactamase 0.0216 0.0457 0.0457
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0028 0.0028
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0043 0.0062 0.0062
Echinococcus granulosus cytochrome P450 2K1 0.004 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0059 0.0099 0.0097
Echinococcus granulosus dna polymerase eta 0.0019 0.0006 0.0006
Echinococcus granulosus cpg binding protein 0.0124 0.0248 0.0248
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0045 0.0674
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0051 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0017 0.0003 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.008 0.008
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0018 0.0018
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0216 0.0457 0.0457
Echinococcus multilocularis mitogen activated protein kinase 0.0156 0.0321 0.0321
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0018 0.0016
Leishmania major DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.004 0.0054 0.0174
Echinococcus granulosus Aminotransferase class III 0.0043 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.008 0.008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0041 0.0041
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0028 0.0334
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0161 0.0747
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0045 0.7244
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.0077
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.023 0.0738
Brugia malayi Inositol-1 0.0036 0.0045 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.008 0.0077
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0099 0.0099
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0017 0.0003 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0041 0.0041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0156 0.0321 0.3878
Schistosoma mansoni ap endonuclease 0.0038 0.0051 0.0051
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0378 0.0828 0.0828
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.008 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0025 0.0113
Echinococcus granulosus dna polymerase kappa 0.0019 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0043 0.0062 1
Trypanosoma brucei cytochrome P450, putative 0.0058 0.0096 0.1158
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0006 0.0078
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0054 0.0656
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0081 0.0974
Plasmodium vivax ornithine aminotransferase, putative 0.0043 0.0062 0.0754
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0069 0.0829
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0161 0.1949
Trichomonas vaginalis esterase, putative 0.0216 0.0457 0.2114
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0017 0.0003 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0059 0.071
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0003 0.003
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0378 0.0828 0.0828
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0246 0.0246
Brugia malayi Doublecortin family protein 0.0059 0.0099 0.0099
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.004 0.0054 0.0174
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.004 0.0054 0.0809
Loa Loa (eye worm) hhat protein 0.0378 0.0828 0.0826
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.004 0.0054 0.0174
Mycobacterium ulcerans aldehyde dehydrogenase 0.031 0.0672 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0018 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.0594 0.0594
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0193 0.0193
Plasmodium falciparum thioredoxin reductase 0.0046 0.0069 0.0829
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.004 0.0054 0.0174
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0041 0.0057 0.0057
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0016 0.0072
Entamoeba histolytica hypothetical protein 0.0322 0.0701 0.8455
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0018 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0006 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.008 0.008
Mycobacterium ulcerans lipase LipD 0.0216 0.0457 0.6806
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0037 0.052
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0011 0.013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0041 0.0038
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0069 0.0829
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0017 0.0003 0.0003
Brugia malayi tailless protein 0.0024 0.0018 0.0018
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0017 0.0003 0.0038
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0321 0.0321
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0025 0.0113
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0294 0.0636 0.0636
Brugia malayi CXXC zinc finger family protein 0.0118 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0216 0.0457 0.0455
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0006 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.008 0.008
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0017 0.0003 0.0038
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0017 0.0003 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0003
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Toxoplasma gondii hypothetical protein 0.0048 0.0073 0.0879
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0017 0.0003 0.0003
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.4389 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.008 0.0077
Echinococcus granulosus o acyltransferase membrane bound domain 0.0378 0.0828 0.0828
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0017 0.0003 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0018 0.0018
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0003 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0962 0.2162 1
Entamoeba histolytica vacuolar protein sorting 26 0.0378 0.0828 1
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0378 0.0828 0.0828
Schistosoma mansoni inositol monophosphatase 0.0036 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0096 0.0182 0.0182
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0045 0.0045
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0025 0.0025
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0017 0.0003 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0378 0.0828 1
Brugia malayi hypothetical protein 0.0322 0.0701 0.0701
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0069 0.0069
Echinococcus multilocularis microtubule associated protein 2 0.1379 0.3118 0.3118
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0378 0.0828 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0156 0.032 0.0318
Mycobacterium ulcerans aldehyde dehydrogenase 0.031 0.0672 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0246 0.0246
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.019 0.0398 0.4801
Leishmania major cytochrome p450-like protein 0.0058 0.0096 0.1158
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0003 0.003
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0003 0.003
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0099 0.0099
Echinococcus multilocularis neuropeptide s receptor 0.0971 0.2185 0.2185
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.0641 0.774
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.004 0.0054 0.0809
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.008 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.008 0.008
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.013
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0017 0.0003 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Loa Loa (eye worm) inositol-1 0.0036 0.0045 0.0043
Leishmania major glycerol uptake protein, putative 0.0378 0.0828 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.008 0.008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0051 0.0049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.008 0.008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0045 0.0209
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.008 0.008
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0099 0.0099
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0216 0.0457 0.0457
Brugia malayi Cytochrome P450 family protein 0.004 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0216 0.0457 0.0455
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.0594 0.0594
Echinococcus multilocularis RUN 0.0059 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.0077
Onchocerca volvulus 0.0216 0.0457 0.2105
Schistosoma mansoni cpg binding protein 0.0124 0.0248 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0078
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.004 0.0054 0.0809
Loa Loa (eye worm) hypothetical protein 0.0051 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.0077
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0054 0.0656
Onchocerca volvulus 0.0216 0.0457 0.2105
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0017 0.0003 0.003
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0145 0.1724
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0043 0.0062 0.093
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0011 0.0011
Echinococcus multilocularis Aminotransferase class III 0.0043 0.0062 0.0062
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0304 0.0659 0.9815
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.019 0.0398 0.0398
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0043 0.0062 0.0913
Echinococcus multilocularis dna polymerase eta 0.0019 0.0006 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.0641 0.774
Leishmania major GTP-binding protein, putative 0.0021 0.0011 0.013
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0017 0.0003 0.0038
Toxoplasma gondii exonuclease III APE 0.0038 0.0051 0.062
Trichomonas vaginalis ran, putative 0.0021 0.0011 0.005
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0017 0.0003 0.0038
Schistosoma mansoni hypothetical protein 0.0322 0.0701 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Entamoeba histolytica hypothetical protein 0.0023 0.0016 0.0158
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0043 0.0062 0.0913
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0284 0.3431
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0017 0.0003 0.003
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0246 0.0246
Trypanosoma cruzi GUP1, putative 0.0378 0.0828 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.008 0.0077
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0203 0.0653
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0246 0.2967
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0161 0.1949
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0016
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0006 0.0078
Schistosoma mansoni lipoxygenase 0.0126 0.0251 0.0251
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0043 0.0062 1
Giardia lamblia Kinase, CMGC MAPK 0.0156 0.0321 0.8077
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.008 0.008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.008 0.008
Trichomonas vaginalis penicillin-binding protein, putative 0.0216 0.0457 0.2114
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0017 0.0003 0.0038
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.013
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0022
Toxoplasma gondii thioredoxin reductase 0.0046 0.0069 0.0829
Echinococcus granulosus survival motor neuron protein 1 0.0468 0.1034 0.1034
Schistosoma mansoni peptidase 0.0017 0.0002 0.0002
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.004 0.0054 0.0809
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.004 0.0054 0.0174
Plasmodium falciparum importin beta, putative 0.0028 0.0028 0.0334
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0016 0.0188
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0078
Brugia malayi hypothetical protein 0.0027 0.0025 0.0025
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0096 0.1158
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.008 0.008
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.004 0.0054 0.0809
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0096 0.0093
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0051 0.0238
Schistosoma mansoni nuclear hormone receptor 0.0051 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0113
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0017 0.0003 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0254 0.0544 0.0544
Schistosoma mansoni loxhd1 0.0059 0.0099 0.0099

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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