Detailed information for compound 622902

Basic information

Technical information
  • TDR Targets ID: 622902
  • Name: 1-(4-chlorophenyl)-2-[(6-nitro-1H-benzimidazo l-2-yl)sulfanyl]ethanone
  • MW: 347.776 | Formula: C15H10ClN3O3S
  • H donors: 1 H acceptors: 4 LogP: 4.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)CSc1nc2c([nH]1)ccc(c2)[N+](=O)[O-]
  • InChi: 1S/C15H10ClN3O3S/c16-10-3-1-9(2-4-10)14(20)8-23-15-17-12-6-5-11(19(21)22)7-13(12)18-15/h1-7H,8H2,(H,17,18)
  • InChiKey: QIKYAJPWGQFDHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-chlorophenyl)-2-[(6-nitro-1H-benzimidazol-2-yl)thio]ethanone
  • ZINC00126437
  • BAS 01318967
  • Oprea1_627897
  • 1-(4-Chloro-phenyl)-2-(5-nitro-1H-benzoimidazol-2-ylsulfanyl)-ethanone
  • MLS000569487
  • SMR000176845

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.024 0.062 0.805
Echinococcus granulosus multidrug resistance associated protein 4 0.0045 0.0087 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0736 0.9215
Echinococcus granulosus snurportin 1 0.0351 0.0923 0.0898
Echinococcus granulosus ATP binding cassette sub family B 0.0025 0.0032 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.024 0.062 1
Brugia malayi P-glycoprotein-like protein 0.0025 0.0032 0.0403
Loa Loa (eye worm) ABC transporter 0.0025 0.0032 0.0349
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0052 0.0108 0.0082
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0063 0.0033
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0052 0.0108 0.0311
Schistosoma mansoni hypothetical protein 0.0043 0.0083 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.001 0.0029
Schistosoma mansoni hypothetical protein 0.0076 0.0171 0.0292
Trypanosoma brucei p-glycoprotein 0.0069 0.0154 0.1928
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0056 0.1463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0764 0.9564
Brugia malayi Ubiquitin-like protein SMT3 0.0035 0.006 0.0753
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0069 0.0859
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0052 0.0108 0.0311
Brugia malayi ABC transporter family protein 0.0025 0.0032 0.0403
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0655
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0052 0.0108 0.1323
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.024 0.062 0.805
Mycobacterium leprae conserved hypothetical protein 0.0035 0.006 0.0824
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0052 0.0108 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0115 0.0197
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0071 0.0858
Mycobacterium tuberculosis Conserved protein 0.0035 0.006 0.0824
Echinococcus multilocularis ATP binding cassette sub family G 0.011 0.0266 0.0236
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.017 0.029
Entamoeba histolytica ATP-binding cassette protein, putative 0.0069 0.0154 0.1903
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0047 0.0092 0.1123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0115 0.1444
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0114 0.0275 0.3423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.044 0.549
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.1323
Echinococcus multilocularis tumor protein p63 0.1059 0.2853 0.2831
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0383 0.478
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0069 0.0154 0.0426
Brugia malayi beta-lactamase family protein 0.0035 0.006 0.0756
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0078 0.0226
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0358 0.3881
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0267 0.334
Loa Loa (eye worm) hypothetical protein 0.0067 0.0147 0.1596
Entamoeba histolytica P-glycoprotein-2, putative 0.0023 0.0026 0.0301
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0052 0.0108 0.135
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0287
Trichomonas vaginalis ABC transporter, putative 0.0047 0.0092 0.1123
Leishmania major hypothetical protein, conserved 0.0035 0.006 0.0167
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.006 0.0727
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0078 0.1121
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0052 0.0108 0.0311
Loa Loa (eye worm) hypothetical protein 0.0148 0.0368 0.3992
Brugia malayi ABC transporter family protein 0.0094 0.022 0.2757
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0032 0.0002
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0032 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0078 0.0982
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0108 0.1169
Onchocerca volvulus 0.0052 0.0108 0.0693
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0071 0.0204
Trypanosoma brucei ATP-binding cassette protein subfamily G 0.0019 0.0016 0.0198
Giardia lamblia GTOR 0.0306 0.0799 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0047 0.0092 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0384 0.4795
Onchocerca volvulus 0.0036 0.0063 0.0039
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0025 0.0032 0.0418
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0052 0.0108 0.0184
Leishmania major phosphatidylinositol kinase related protein, putative 0.0052 0.0108 0.0298
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0025 0.0032 0.0421
Trypanosoma brucei multidrug resistance protein E 0.0069 0.0154 0.1928
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.011 0.0266 0.3447
Trypanosoma cruzi small ubiquitin protein, putative 0.0035 0.006 0.0173
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.006 0.0655
Giardia lamblia ABC transporter, putative 0.0069 0.0154 0.1928
Schistosoma mansoni multidrug resistance protein 0.0069 0.0154 0.0263
Onchocerca volvulus Huntingtin homolog 0.0148 0.0368 0.4497
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0035 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0108 0.135
Echinococcus multilocularis snurportin 1 0.0351 0.0923 0.0895
Plasmodium falciparum importin beta, putative 0.0033 0.0054 0.142
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0052 0.0108 0.1323
Loa Loa (eye worm) hypothetical protein 0.0052 0.0108 0.1169
Entamoeba histolytica hypothetical protein 0.0052 0.0108 0.1323
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0114 0.0275 0.3423
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0056 0.1463
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0025 0.0032 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.006 0.0724
Mycobacterium ulcerans O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD 0.0017 0.001 0.0131
Entamoeba histolytica hypothetical protein 0.0052 0.0108 0.1323
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.024 0.062 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.017 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0273 0.0709 0.1209
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0047 0.0092 0.1123
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0052 0.0108 0.1411
Toxoplasma gondii ATP-binding cassette G family transporter ABCG96 0.0019 0.0016 0.0207
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0115 0.0089
Mycobacterium ulcerans antibiotic ABC transporter transmembrane protein 0.0017 0.001 0.0131
Loa Loa (eye worm) hypothetical protein 0.0101 0.0241 0.2614
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0026 0.0301
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.0303 0.0277
Plasmodium vivax ABC transporter B family member 5, putative 0.0025 0.0032 0.084
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0047 0.0092 0.1123
Brugia malayi Ets-domain containing protein 0.0078 0.0178 0.2231
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Leishmania major ATP-binding cassette protein subfamily G, member 1, putative 0.0019 0.0016 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0764 0.9564
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0066 0.0183
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0047 0.0092 0.1123
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0296 0.0771 0.9654
Toxoplasma gondii cytochrome p450 superfamily protein 0.024 0.062 0.8119
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0002 0.0007
Plasmodium vivax SET domain protein, putative 0.0036 0.0063 0.1645
Toxoplasma gondii target of rapamycin (TOR), putative 0.0293 0.0764 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0056 0.0734
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0052 0.0108 0.1169
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.006 0.0813
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0041 0.0519
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0033 0.0055 0.0664
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0033 0.0055 0.0664
Loa Loa (eye worm) cytochrome P450 family protein 0.0262 0.068 0.7368
Onchocerca volvulus 0.0286 0.0745 1
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0025 0.0032 0.0093
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0273 0.0709 0.8872
Echinococcus granulosus multidrug resistance protein 1 0.0047 0.0092 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0673
Loa Loa (eye worm) hypothetical protein 0.0069 0.0154 0.167
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0047 0.0092 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.2162 0.5863 0.5851
Mycobacterium ulcerans daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC 0.0017 0.001 0.0131
Trypanosoma brucei ATP-binding cassette protein, putative 0.011 0.0266 0.3325
Leishmania major ABC-thiol transporter 0.0069 0.0154 0.0426
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0056 0.0734
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0021 0.0035
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0025 0.0032 0.0093
Loa Loa (eye worm) Csnk2b protein 0.0114 0.0275 0.2982
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0154 0.0384 0.1107
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0273 0.0709 0.1961
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0071 0.0858
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0108 0.135
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0047 0.0092 0.1123
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0101 0.0241 0.0695
Entamoeba histolytica ABC transporter, putative 0.0069 0.0154 0.1903
Echinococcus granulosus casein kinase ii subunit alpha 0.0153 0.0383 0.0358
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0027 0.0701
Echinococcus granulosus cytochrome P450 2K1 0.024 0.062 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0474 0.5926
Brugia malayi Pre-SET motif family protein 0.0036 0.0063 0.0789
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0035 0.0414
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0025 0.0032 0.084
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0063 0.0037
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0303 0.0873
Brugia malayi FAT domain containing protein 0.0119 0.0289 0.3619
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0052 0.0108 0.0298
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.003 0.0004
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0047 0.0092 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0736 0.9215
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.006 0.0727
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0303 0.3792
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0052 0.0108 0.1323
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.024 0.062 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.0303 0.4799
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0047 0.0092 0.1123
Plasmodium falciparum multidrug resistance protein 1 0.0047 0.0092 0.2399
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0303 0.3773
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0154 0.0384 0.0355
Loa Loa (eye worm) glutaminase 2 0.0295 0.0771 0.8353
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.024 0.062 0.805
Echinococcus granulosus Small ubiquitin modifier 2 0.0035 0.006 0.0034
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0047 0.0092 0.1123
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0016 0.0046
Trypanosoma cruzi multidrug resistance protein E, putative 0.0069 0.0154 0.0444
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.017 0.014
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.024 0.062 0.805
Brugia malayi beta-lactamase 0.0035 0.006 0.0756
Loa Loa (eye worm) hypothetical protein 0.0069 0.0154 0.1665
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.0771 0.9652
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0052 0.0108 0.1323
Loa Loa (eye worm) hypothetical protein 0.0119 0.0289 0.3134
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0655
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0032 0.0421
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0052 0.0108 0.0311
Toxoplasma gondii FATC domain-containing protein 0.0154 0.0384 0.503
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.011 0.0266 0.3447
Brugia malayi phosphofructokinase 0.0124 0.0303 0.3792
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0383 0.478
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0306 0.0799 1
Mycobacterium ulcerans antibiotic ABC transporter integral membrane protein 0.0017 0.001 0.0131
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.017 0.0471
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.024 0.062 0.805
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0025 0.0032 0.084
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0025 0.0032 0.0362
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0063 0.0107
Brugia malayi Pre-SET motif family protein 0.0251 0.065 0.8142
Mycobacterium ulcerans hypothetical protein 0.0017 0.001 0.0131
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0019 0.0016 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.024 0.062 1
Loa Loa (eye worm) glutaminase 0.0295 0.0771 0.8353
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0306 0.0799 1
Trichomonas vaginalis rotamase, putative 0.0038 0.0069 0.083
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0273 0.0709 0.0681
Mycobacterium tuberculosis Conserved protein 0.0035 0.006 0.0824
Echinococcus granulosus ATP binding cassette sub family B 0.0025 0.0032 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.024 0.062 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0306 0.0799 0.221
Mycobacterium ulcerans daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB 0.0017 0.001 0.0131
Giardia lamblia Multidrug resistance-associated protein 1 0.0069 0.0154 0.1928
Echinococcus multilocularis casein kinase ii subunit alpha 0.0153 0.0383 0.0354
Echinococcus multilocularis 0.0025 0.0032 0.0002
Plasmodium falciparum multidrug resistance-associated protein 1 0.0025 0.0032 0.084
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0054 0.0024
Brugia malayi RE11181p 0.0017 0.001 0.0126
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0069 0.0154 0.0444
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.006 0.0824
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.0303 0.0274
Leishmania major cytochrome p450-like protein 0.024 0.062 0.1716
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0078 0.0052
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0306 0.0799 0.0774
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0052 0.0108 0.1411
Leishmania major p-glycoprotein 0.0047 0.0092 0.0254
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0108 0.2814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0115 0.0086
Mycobacterium leprae Conserved hypothetical protein 0.024 0.062 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0432 0.5397
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0071 0.0204
Loa Loa (eye worm) ABC transporter 0.0094 0.022 0.2387
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.024 0.062 0.805
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0655
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0037 0.0439
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 0.0174
Echinococcus granulosus geminin 0.0205 0.0523 0.0498
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0052 0.0108 0.0082
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0114 0.0275 0.0792
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0114 0.0275 0.3443
Trypanosoma cruzi ATP-binding cassette protein subfamily G 0.0019 0.0016 0.0046
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0653
Leishmania major phosphatidylinositol 3-kinase, putative 0.0273 0.0709 0.1961
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0069 0.0154 0.1928
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0066 0.0191
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.0178 0.1931
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.011 0.0266 0.0453
Giardia lamblia MRP-like ABC transporter 0.0069 0.0154 0.1928
Echinococcus multilocularis casein kinase ii subunit beta 0.0114 0.0275 0.0246
Brugia malayi MH2 domain containing protein 0.0144 0.0358 0.4482
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0052 0.0108 0.1323
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0056 0.1463
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.024 0.062 0.1787
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0084 0.0054
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0108 0.1169
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0289 0.3599
Loa Loa (eye worm) phosphatidylinositol 3 0.0273 0.0709 0.7682
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.024 0.062 1
Echinococcus multilocularis multidrug resistance associated protein 4 0.0045 0.0087 0.0057
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0119 0.0289 0.026
Leishmania major phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.0298
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0078 0.0049
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.003 0.0004
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.017 0.1844
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0025 0.0032 0.0362
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0084 0.0057
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.0303 0.0838
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0267 0.2892
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0108 0.135
Echinococcus granulosus casein kinase ii subunit beta 0.0114 0.0275 0.0249
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0078 0.0217
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0273 0.0709 0.0684
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0078 0.0226
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0108 0.135
Trypanosoma brucei unspecified product 0.0029 0.0043 0.054
Plasmodium falciparum ABC transporter B family member 4, putative 0.0025 0.0032 0.084
Entamoeba histolytica hypothetical protein 0.0069 0.0154 0.1903
Plasmodium vivax ABC transporter B family member 4, putative 0.0025 0.0032 0.084
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0041 0.0115
Loa Loa (eye worm) phosphofructokinase 0.0124 0.0303 0.3284
Echinococcus granulosus importin subunit beta 1 0.0033 0.0054 0.0028
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0655
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0047 0.0092 0.1123
Brugia malayi casein kinase II, putaitve 0.0033 0.0055 0.0693
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.1014
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0052 0.0108 0.0078
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.006 0.0727
Toxoplasma gondii ABC transporter, putative 0.0025 0.0032 0.0421
Echinococcus multilocularis geminin 0.0205 0.0523 0.0494
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.065 0.705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0736 0.9217
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0047 0.0092 0.0066
Schistosoma mansoni ABC transporter 0.0094 0.022 0.0376
Brugia malayi hypothetical protein 0.0148 0.0368 0.4611
Mycobacterium ulcerans hypothetical protein 0.0035 0.006 0.0784
Mycobacterium ulcerans glutaminase 0.0295 0.0771 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0154 0.0384 0.4811
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.011 0.0266 0.0735
Brugia malayi Importin beta-1 subunit 0.0033 0.0054 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0764 0.9564
Giardia lamblia Hypothetical protein 0.0052 0.0108 0.135
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0069 0.0154 0.2016
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0052 0.0108 0.1323
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0035 0.0414
Leishmania major lanosterol 14-alpha-demethylase, putative 0.024 0.062 0.1716
Entamoeba histolytica P-glycoprotein-1 0.0047 0.0092 0.1123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0059 0.0033
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0306 0.0799 0.2301
Trypanosoma cruzi small ubiquitin protein, putative 0.0035 0.006 0.0173
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0052 0.0108 0.1411
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0052 0.0108 0.2814
Trypanosoma brucei Casein kinase II 0.0153 0.0383 0.4797
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0025 0.0032 0.0089
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0052 0.0108 0.1323
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0047 0.0092 0.1123
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0349
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0069 0.0154 0.0426
Echinococcus granulosus bloom syndrome protein 0.0026 0.0035 0.0009
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0069 0.0154 0.0444
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0673
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0071 0.0919
Trypanosoma brucei DNA polymerase eta, putative 0.0069 0.0154 0.1923
Loa Loa (eye worm) cytochrome P450 family protein 0.025 0.0648 0.7019
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0078 0.0954
Schistosoma mansoni cellular tumor antigen P53 0.0155 0.0387 0.0661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0063 0.0107
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0103
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0052 0.0108 0.1323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0384 0.4795
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0071 0.0858
Plasmodium vivax ABC transporter B family member 7, putative 0.0025 0.0032 0.084
Schistosoma mansoni multidrug resistance protein 0.0069 0.0154 0.0263
Brugia malayi ABC transporter 0.0025 0.0032 0.0403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.006 0.0103
Echinococcus multilocularis dna polymerase eta 0.0069 0.0154 0.0124
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.0303 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0032 0.0421
Trichomonas vaginalis abcb9, putative 0.0047 0.0092 0.1123
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.017 0.2129
Brugia malayi ABC transporter family protein 0.0047 0.0092 0.1151
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0303 0.3773
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0673
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0075 0.0983
Echinococcus multilocularis GPCR, family 2 0.0035 0.006 0.003
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.024 0.062 0.1787
Giardia lamblia Phosphatidylinositol 4-kinase 0.0052 0.0108 0.135
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.024 0.062 0.805
Plasmodium vivax multidrug resistance protein 2, putative 0.0025 0.0032 0.084
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.0923 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.083
Leishmania major p-glycoprotein e 0.0069 0.0154 0.0426
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.006 0.0813
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0296 0.0771 0.2133
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.006 0.0824
Echinococcus multilocularis multidrug resistance protein 1 0.0047 0.0092 0.0062
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0047 0.0092 0.1123
Schistosoma mansoni hypothetical protein 0.0052 0.0108 0.0184
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.017 0.049
Entamoeba histolytica protein kinase rad3, putative 0.0154 0.0384 0.4795
Loa Loa (eye worm) hypothetical protein 0.0111 0.0267 0.2892
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0047 0.0092 0.0062
Brugia malayi Latrophilin receptor protein 2 0.0035 0.006 0.0754
Schistosoma mansoni hypothetical protein 0.0205 0.0523 0.0892
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0071 0.0041
Leishmania major small ubiquitin protein, putative 0.0035 0.006 0.0166
Brugia malayi ABC transporter family protein 0.0025 0.0032 0.0403
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Schistosoma mansoni smdr2 0.0047 0.0092 0.0157
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0023 0.0026 0.0331
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.1323
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0114 0.0275 0.3135
Toxoplasma gondii ATP-binding cassette G family transporter ABCG89 0.0019 0.0016 0.0207
Plasmodium falciparum flap endonuclease 1 0.0028 0.0041 0.1082
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0303 0.3773
Trypanosoma cruzi hypothetical protein 0.0045 0.0087 0.0249
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0047 0.0092 0.1123
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0066 0.0828
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0303 0.3284
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3678 1 1
Plasmodium vivax ABC transporter G family member 2, putative 0.011 0.0266 0.6932
Leishmania major casein kinase II, putative 0.0153 0.0383 0.106
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0052 0.0108 0.2814
Echinococcus granulosus ATP binding cassette sub family G 0.011 0.0266 0.024
Giardia lamblia Sentrin 0.0035 0.006 0.0753
Brugia malayi ABC transporter transmembrane region family protein 0.0069 0.0154 0.1928
Schistosoma mansoni inositol monophosphatase 0.0039 0.0071 0.0121
Brugia malayi ABC transporter transmembrane region family protein 0.0023 0.0026 0.0331
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0078 0.0851
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.024 0.062 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0052 0.0108 0.0082
Schistosoma mansoni multidrug resistance protein 0.0069 0.0154 0.0263
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0047 0.0092 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0799 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0086 0.0934
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0041 0.0519
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0052 0.0108 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.0771 0.9652
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0066 0.08
Trypanosoma cruzi ABC transporter, putative 0.0019 0.0016 0.0046
Schistosoma mansoni inositol monophosphatase 0.0039 0.0071 0.0121
Trypanosoma cruzi ATP-binding cassette protein, putative 0.011 0.0266 0.0765
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0047 0.0092 0.0062
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0052 0.0108 0.2814
Leishmania major importin beta-1 subunit, putative 0.0027 0.0037 0.0104
Onchocerca volvulus Huntingtin homolog 0.0148 0.0368 0.4497
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0041 0.0489
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0041 0.0011
Loa Loa (eye worm) hypothetical protein 0.0076 0.0171 0.1856
Entamoeba histolytica P-glycoprotein 6, putative 0.0025 0.0032 0.0373
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0306 0.0799 0.221
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0154 0.0384 0.0655
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0154 0.0384 0.0359
Brugia malayi Flap endonuclease-1 0.0028 0.0041 0.0519
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.024 0.062 0.805
Trichomonas vaginalis ABC transporter, putative 0.0047 0.0092 0.1123
Toxoplasma gondii ATP-binding cassette G family transporter ABCG87 0.0019 0.0016 0.0207
Trichomonas vaginalis ABC transporter, putative 0.0047 0.0092 0.1123
Loa Loa (eye worm) hypothetical protein 0.0047 0.0092 0.0996
Loa Loa (eye worm) ABC transporter 0.0025 0.0032 0.0349
Leishmania major hypothetical protein, conserved 0.1338 0.3615 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0002 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0108 0.1169
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0047 0.0092 0.1341
Loa Loa (eye worm) hypothetical protein 0.0155 0.0387 0.42
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.024 0.062 0.805
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0033 0.0055 0.0664
Mycobacterium ulcerans antibiotic resistance ABC transporter efflux protein 0.0017 0.001 0.0131
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0025 0.0032 0.0418
Plasmodium vivax casein kinase II beta chain, putative 0.0114 0.0275 0.7179
Trichomonas vaginalis ABC transporter, putative 0.0047 0.0092 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0736 0.9217
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0041 0.0543
Schistosoma mansoni multidrug resistance protein 0.0025 0.0032 0.0055
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0025 0.0032 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0023 0.0026 0.0045
Echinococcus multilocularis expressed protein 0.0038 0.0069 0.0039
Leishmania major phosphatidylinositol 4-kinase, putative 0.0052 0.0108 0.0298
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.006 0.0824
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0032 0.0421
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.0154 0.0442
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0078 0.0134
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.2814
Giardia lamblia Casein kinase II beta chain 0.0114 0.0275 0.3443
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.024 0.062 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0306 0.0799 0.8659
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0108 0.135
Mycobacterium tuberculosis Conserved hypothetical protein 0.0052 0.0108 0.1602
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.024 0.062 0.805
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0063 0.0825
Loa Loa (eye worm) ABC transporter 0.0025 0.0032 0.0349
Echinococcus granulosus tumor protein p63 0.1059 0.2853 0.2834
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0052 0.0108 0.135
Mycobacterium leprae putative cytochrome p450 0.024 0.062 1
Brugia malayi ABC transporter family protein 0.0025 0.0032 0.0403
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0108 0.135
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.1323
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Brugia malayi hypothetical protein 0.0043 0.0083 0.1042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0115 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0078 0.0226
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0383 0.478
Schistosoma mansoni DNA polymerase eta 0.0069 0.0154 0.0262
Toxoplasma gondii ABC transporter family protein 0.0025 0.0032 0.0421
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.024 0.062 1
Brugia malayi Ets-domain containing protein 0.0078 0.0178 0.2231
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0052 0.0108 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.006 0.0034
Echinococcus multilocularis 0.0052 0.0108 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Loa Loa (eye worm) fli-1 protein 0.0238 0.0613 0.6643
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0047 0.0092 0.1203
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0383 0.478
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0303 0.0517
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0083 0.0142
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.011 0.0266 0.3476
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0002 0.0031
Entamoeba histolytica ABC transporter, putative 0.011 0.0266 0.3304
Brugia malayi 6-phosphofructokinase 0.0124 0.0303 0.3792
Trypanosoma cruzi ABC transporter, putative 0.0017 0.001 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0052 0.0108 0.1602
Schistosoma mansoni gabp alpha 0.0078 0.0178 0.0304
Mycobacterium ulcerans beta-lactamase 0.0035 0.006 0.0784
Loa Loa (eye worm) hypothetical protein 0.0171 0.0432 0.4685
Schistosoma mansoni hypothetical protein 0.0092 0.0214 0.0366
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.1323
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0303 0.3773
Echinococcus granulosus ATP binding cassette sub family G 0.011 0.0266 0.024
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0052 0.0108 0.135
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.011 0.0266 0.3447
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0736 0.9215
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0056 0.0673
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0052 0.0108 0.0184
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.024 0.062 0.805
Onchocerca volvulus 0.0155 0.0387 0.4777
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0078 0.0982
Schistosoma mansoni cytochrome P450 0.024 0.062 0.1058
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0078 0.1018
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0114 0.0275 0.0761
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Schistosoma mansoni microtubule-associated protein tau 0.2162 0.5863 1
Leishmania major DNA polymerase eta, putative 0.0069 0.0154 0.0425
Entamoeba histolytica P-glycoprotein 5, putative 0.0047 0.0092 0.1123
Plasmodium falciparum multidrug resistance protein 2 0.0025 0.0032 0.084
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0047 0.0092 0.0066
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0103
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0383 0.478
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0264 0.0685 0.7429
Schistosoma mansoni fkbp-rapamycin associated protein 0.0154 0.0384 0.0655
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0052 0.0108 0.135
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0154 0.0384 0.4811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0709 0.8868
Entamoeba histolytica ubiquitin like protein 0.0035 0.006 0.0724
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0025 0.0032 0.0362
Leishmania major cytochrome p450-like protein 0.024 0.062 0.1716
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0114 0.0275 0.3135
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0047 0.0092 0.0254
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0025 0.0032 0.0403
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0032 0.0002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0052 0.0108 0.1323
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0383 0.478
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.024 0.062 0.805
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0063 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0108 0.1323
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0033 0.0055 0.0664
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0103
Echinococcus multilocularis multidrug resistance associated protein 1 0.0069 0.0154 0.0124
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0083 0.0053
Onchocerca volvulus 0.0047 0.0092 0.046
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0037 0.0439
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.0178 0.0149
Entamoeba histolytica hypothetical protein 0.0027 0.0037 0.0439
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0052 0.0108 0.1323
Plasmodium falciparum casein kinase II beta chain 0.0114 0.0275 0.7179
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.024 0.062 0.7766
Leishmania major DNA polymerase kappa, putative 0.0042 0.0078 0.0217
Entamoeba histolytica P-glycoprotein 6, putative 0.0025 0.0032 0.0373
Trypanosoma brucei small ubiquitin-related modifier 0.0035 0.006 0.0753
Trypanosoma cruzi casein kinase II, putative 0.0153 0.0383 0.1104
Echinococcus granulosus multidrug resistance associated protein 7 0.0069 0.0154 0.0128
Plasmodium vivax ABC transporter B family member 6, putative 0.0025 0.0032 0.084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0135 0.167
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0047 0.0092 0.0062
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0041 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0108 0.1323
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.017 0.2129
Onchocerca volvulus 0.0052 0.0108 0.0693
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.025 0.0648 0.8404
Giardia lamblia DINP protein human, muc B family 0.0042 0.0078 0.0982
Brugia malayi 6-phosphofructokinase 0.0126 0.0309 0.3864
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0306 0.0799 0.0771
Loa Loa (eye worm) beta-lactamase 0.0035 0.006 0.0655
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0052 0.0108 0.0078
Plasmodium vivax importin-beta 2, putative 0.0033 0.0054 0.142
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0241 0.2997
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0047 0.0092 0.1123
Trypanosoma brucei unspecified product 0.0042 0.0078 0.0982
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0043 0.054
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0925 0.2488 0.2465
Plasmodium vivax casein kinase II beta chain, putative 0.0114 0.0275 0.7179
Plasmodium vivax ABC transporter B family member 3, putative 0.0025 0.0032 0.084
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.024 0.062 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.006 0.003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0576 0.9276
Entamoeba histolytica ATP-binding cassette protein, putative 0.0069 0.0154 0.1903
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.024 0.062 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0032 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0384 0.4795
Echinococcus granulosus expressed protein 0.0038 0.0069 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0108 0.1169
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0025 0.0032 0.0418
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0069 0.0154 0.0426
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0032 0.0421
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0052 0.0108 0.0311
Echinococcus granulosus serine protein kinase ATM 0.0154 0.0384 0.0359
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0306 0.0799 1
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0037 0.0439
Loa Loa (eye worm) hypothetical protein 0.0131 0.0321 0.3479
Loa Loa (eye worm) multidrug resistance-associated protein 0.0047 0.0092 0.1
Echinococcus multilocularis ATP binding cassette sub family B 0.0045 0.0086 0.0056
Entamoeba histolytica ATP-binding cassette protein, putative 0.0069 0.0154 0.1903
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.006 0.0103
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0052 0.0108 0.0082
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0182 0.046 0.5758
Leishmania major cytochrome p450-like protein 0.025 0.0648 0.1791
Leishmania major ATP-binding cassette protein subfamily G, member 2, putative 0.0019 0.0016 0.0044
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0047 0.0092 0.1123
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.024 0.062 0.805
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0171 0.0432 0.5657
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0052 0.0108 0.0311
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0306 0.0799 0.2301
Plasmodium falciparum ABC transporter G family member 2 0.011 0.0266 0.6932
Giardia lamblia ABC transporter 0.0108 0.026 0.3253
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.006 0.0824
Brugia malayi RNA, U transporter 1 0.0094 0.022 0.2752
Entamoeba histolytica P-glycoprotein-2, putative 0.0047 0.0092 0.1123
Trichomonas vaginalis esterase, putative 0.0035 0.006 0.0727
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0052 0.0108 0.0082
Echinococcus multilocularis serine protein kinase ATM 0.0154 0.0384 0.0355
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0069 0.0744
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0303 0.3773
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0056 0.0734
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0071 0.0927
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0052 0.0108 0.0311
Entamoeba histolytica P-glycoprotein 5, putative 0.0023 0.0026 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Loa Loa (eye worm) hypothetical protein 0.0069 0.0154 0.167
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0078 0.0982
Giardia lamblia Casein kinase II beta chain 0.0033 0.0055 0.0693
Trypanosoma brucei cytochrome P450, putative 0.025 0.0648 0.8107
Trichomonas vaginalis taga, putative 0.0047 0.0092 0.1123
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0066 0.0866
Plasmodium falciparum ABC transporter B family member 7, putative 0.0025 0.0032 0.084
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0056 0.1463
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0054 0.0681
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Echinococcus multilocularis multidrug resistance associated protein 7 0.0069 0.0154 0.0124
Echinococcus granulosus dna polymerase kappa 0.0042 0.0078 0.0052
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0025 0.0032 0.0418
Entamoeba histolytica P-glycoprotein-2 0.0047 0.0092 0.1123
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0032 0.0002
Schistosoma mansoni hypothetical protein 0.0119 0.0289 0.0493
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0013 0.0327
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0273 0.0709 0.2041
Trichomonas vaginalis abcb9, putative 0.0047 0.0092 0.1123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.006 0.0754
Loa Loa (eye worm) SMO-1 protein 0.0035 0.006 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0764 0.9564
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0109
Trypanosoma cruzi cytochrome p450-like protein, putative 0.024 0.062 0.1787
Plasmodium falciparum multidrug resistance-associated protein 2 0.0025 0.0032 0.084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0764 0.9564
Entamoeba histolytica protein kinase domain containing protein 0.0153 0.0383 0.478
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0052 0.0108 0.135
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0026 0.0301
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.006 0.0756
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0071 0.0858
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.024 0.062 0.805
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0032 0.0421
Echinococcus granulosus ATP binding cassette sub family G 0.011 0.0266 0.024
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0035 0.0444
Brugia malayi Fli-1 protein 0.0238 0.0613 0.7672
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0069 0.0154 0.0426
Mycobacterium ulcerans lipase LipD 0.0035 0.006 0.0784
Brugia malayi Cytochrome P450 family protein 0.025 0.0648 0.8107
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0052 0.0108 0.1323
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Plasmodium falciparum casein kinase 2, alpha subunit 0.0153 0.0383 1
Trypanosoma cruzi ABC transporter, putative 0.0017 0.001 0.0029
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0303 0.3773
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.024 0.062 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.024 0.062 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0052 0.0108 0.1169
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0071 0.0196
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0012 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0799 1
Schistosoma mansoni glutaminase 0.0295 0.0771 0.1314
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.006 0.003
Leishmania major ATP-binding cassette protein subfamily G, member 5, putative 0.0019 0.0016 0.0044
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0056 0.0673
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0025 0.0032 0.0403
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0083 0.0057
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0052 0.0108 0.1323
Loa Loa (eye worm) inositol-1 0.0039 0.0071 0.0767
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0025 0.0032 0.0089
Echinococcus multilocularis ATP binding cassette sub family G 0.011 0.0266 0.0236
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0115 0.1251
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Echinococcus granulosus GPCR family 2 0.0035 0.006 0.0034
Brugia malayi Cytochrome P450 family protein 0.025 0.0648 0.8107
Entamoeba histolytica multidrug resistance protein, putative 0.0069 0.0154 0.1903
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.003 0.0347
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0047 0.0092 0.1123
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.006 0.0824
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.017 0.2105
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0075 0.0216
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0154 0.0384 0.1107
Brugia malayi beta-lactamase family protein 0.0035 0.006 0.0756
Schistosoma mansoni ets-related 0.0238 0.0613 0.1045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0115 0.0197
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0078 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Brugia malayi hypothetical protein 0.0017 0.001 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0736 0.9217
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.024 0.062 0.805
Trypanosoma cruzi hypothetical protein, conserved 0.1285 0.3472 1
Brugia malayi Inositol-1 0.0039 0.0071 0.0886
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0047 0.0092 0.1203
Entamoeba histolytica hypothetical protein 0.0052 0.0108 0.1323
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.006 0.0824
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.006 0.0784
Loa Loa (eye worm) hypothetical protein 0.0052 0.0108 0.1169
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0052 0.0108 0.1323
Echinococcus granulosus flap endonuclease 1 0.0028 0.0041 0.0015
Leishmania major DNA polymerase eta, putative 0.004 0.0075 0.0208
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0052 0.0108 0.0082
Loa Loa (eye worm) RecQ helicase 0.0026 0.0035 0.0384
Loa Loa (eye worm) hypothetical protein 0.0067 0.0148 0.1608
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.0311
Brugia malayi cytochrome P450 0.024 0.062 0.7766
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0078 0.0954
Entamoeba histolytica ATP-binding cassette protein, putative 0.0069 0.0154 0.1903
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0054 0.0681
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0103
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0025 0.0032 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0016 0.0046
Trypanosoma brucei unspecified product 0.0029 0.0043 0.054
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.0178 0.0152
Brugia malayi glutaminase DH11.1 0.0295 0.0771 0.9647
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0047 0.0092 0.0996
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0052 0.0108 0.1323
Schistosoma mansoni rotamase 0.0038 0.0069 0.0117
Giardia lamblia Multidrug resistance-associated protein 1 0.0069 0.0154 0.1928
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0267 0.334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0709 0.8868
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0047 0.0092 0.1123
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0153 0.0383 0.4153
Brugia malayi Csnk2b protein 0.0114 0.0275 0.3443
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0078 0.1018
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.024 0.062 1
Toxoplasma gondii small ubiquitin family modifier, putative 0.0035 0.006 0.0787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.044 0.549
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.006 0.003
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0047 0.0092 0.0062
Echinococcus multilocularis Zinc finger, PHD finger 0.0052 0.0108 0.0078
Plasmodium vivax multidrug resistance protein 1, putative 0.0047 0.0092 0.2399
Trichomonas vaginalis abcb9, putative 0.0047 0.0092 0.1123
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0052 0.0108 0.0311
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0071 1
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.1014
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0171 0.2143
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0047 0.0092 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0115 0.0197
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0025 0.0032 0.0403
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0041 0.0119
Loa Loa (eye worm) cytochrome P450 family protein 0.025 0.0648 0.7019
Leishmania major pentamidine resistance protein 1 0.0069 0.0154 0.0426
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.006 0.0784
Plasmodium falciparum ABC transporter B family member 3, putative 0.0025 0.0032 0.084
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.024 0.062 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0108 0.1169
Brugia malayi ImpB/MucB/SamB family protein 0.0069 0.0154 0.1923
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0078 0.0982
Toxoplasma gondii ATP-binding cassette G family transporter ABCG107 0.0019 0.0016 0.0207
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0078 0.0954
Trypanosoma brucei ABC transporter, putative 0.011 0.0266 0.3325
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0047 0.0092 0.1123
Schistosoma mansoni multidrug resistance protein 0.0047 0.0092 0.0157
Echinococcus multilocularis ATP binding cassette sub family G 0.011 0.0266 0.0236
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0054 0.0712
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0799 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0026 0.0301
Echinococcus granulosus multidrug resistance protein 1 0.0047 0.0092 0.0066
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0066 0.0191
Entamoeba histolytica hypothetical protein 0.0154 0.0384 0.4795
Trypanosoma brucei ABC transporter, putative 0.0019 0.0016 0.0198
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0052 0.0108 0.0184
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.006 0.0727
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0154 0.0384 0.4795
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.011 0.0266 0.0735
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0052 0.0108 0.2814
Echinococcus multilocularis 0.024 0.062 0.0592
Loa Loa (eye worm) hypothetical protein 0.0047 0.0092 0.0996
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0303 0.3284
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.024 0.062 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0358 0.3881
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0273 0.0709 0.8872
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.024 0.062 0.805
Plasmodium vivax small ubiquitin-related modifier, putative 0.0035 0.006 0.157
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0092 0.0214 0.335
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.017 0.0144
Loa Loa (eye worm) CYP4Cod1 0.025 0.0648 0.7019
Brugia malayi ABC transporter transmembrane region family protein 0.0025 0.0032 0.0403
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0052 0.0108 0.0078
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0109
Entamoeba histolytica ATP-binding cassette sub-family G1, putative 0.0017 0.001 0.0095
Loa Loa (eye worm) hypothetical protein 0.0148 0.0368 0.3992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.0771 0.9652
Trypanosoma cruzi target of rapamycin kinase 3 0.0296 0.0771 0.2221
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0383 0.478
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0043 0.054
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0709 0.8872
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0655
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.024 0.062 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0052 0.0108 0.0078
Loa Loa (eye worm) hypothetical protein 0.0154 0.0384 0.4166
Schistosoma mansoni multidrug resistance protein 0.0047 0.0092 0.0157
Trypanosoma cruzi cytochrome P450, putative 0.025 0.0648 0.1865
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0709 0.8868
Trypanosoma cruzi ABC transporter, putative 0.011 0.0266 0.0765
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0047 0.0092 0.1123
Loa Loa (eye worm) casein kinase II 0.0033 0.0055 0.06
Schistosoma mansoni ABC transporter 0.0017 0.001 0.0017
Toxoplasma gondii ABC1 family protein 0.0035 0.006 0.079
Schistosoma mansoni hypothetical protein 0.0351 0.0923 0.1573
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Leishmania major phosphatidylinositol kinase, putative 0.0052 0.0108 0.0298
Entamoeba histolytica P-glycoprotein-5 0.0047 0.0092 0.1123
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0109
Giardia lamblia Kinase, CMGC CK2 0.0153 0.0383 0.4797
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0119 0.0289 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0241 0.2997
Brugia malayi hypothetical protein 0.0025 0.0032 0.0403
Plasmodium falciparum casein kinase II beta chain 0.0114 0.0275 0.7179
Schistosoma mansoni protein kinase 0.0153 0.0383 0.0653
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0052 0.0108 0.2814
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0052 0.0108 0.1411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0709 0.8868
Schistosoma mansoni importin beta-1 0.0033 0.0054 0.0093
Echinococcus multilocularis multidrug resistance protein 1 0.0047 0.0092 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0115 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0673
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0303 0.3773
Echinococcus multilocularis Small ubiquitin modifier 2 0.0035 0.006 0.003
Mycobacterium tuberculosis Conserved protein 0.0035 0.006 0.0824
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.006 0.0653
Trichomonas vaginalis rotamase, putative 0.0037 0.0066 0.08
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0069 0.0154 0.1928
Schistosoma mansoni flap endonuclease-1 0.0025 0.0034 0.0058
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0047 0.0092 0.0062
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0154 0.0384 0.4811
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0114 0.0275 0.36
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0153 0.0383 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.006 0.1576
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.006 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.0771 0.9652
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0306 0.0799 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.0495 0.618
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.1014
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.1323
Schistosoma mansoni multidrug resistance protein 0.0069 0.0154 0.0263
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0052 0.0108 0.0184
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.024 0.062 0.805
Brugia malayi Cytochrome P450 family protein 0.024 0.062 0.7766
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0052 0.0108 0.1323
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0108 0.135
Entamoeba histolytica P-glyco protein 6, putative 0.0047 0.0092 0.1123
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0078 0.0134
Schistosoma mansoni multidrug resistance protein 0.0047 0.0092 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0799 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.006 0.0756
Plasmodium vivax hypothetical protein 0.0052 0.0108 0.2814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0709 0.8868
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0078 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0764 0.9564
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.024 0.062 0.805
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0745 0.9325
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.024 0.062 0.805
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0047 0.0092 0.1123
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0052 0.0108 0.1323
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0655
Mycobacterium leprae Probable lipase LipE 0.0035 0.006 0.0824
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0052 0.0108 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0078 0.1121
Giardia lamblia Multidrug resistance-associated protein 1 0.0067 0.0148 0.1857
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0063 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.024 0.062 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0043 0.054
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.024 0.062 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0047 0.0092 0.1123
Echinococcus granulosus dna polymerase eta 0.0069 0.0154 0.0127
Echinococcus granulosus multidrug resistance protein 1 0.0047 0.0092 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0285 0.0743 0.9305
Plasmodium vivax unspecified product 0.0153 0.0383 1
Toxoplasma gondii CMGC kinase, CK2 family 0.0153 0.0383 0.5015
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0114 0.0275 0.0792
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0047 0.0092 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0078 0.0226
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0306 0.0799 0.1362
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0052 0.0108 0.0184
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0041 0.0489
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0069 0.0154 0.167
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.024 0.062 1
Trypanosoma cruzi cytochrome P450, putative 0.025 0.0648 0.1865
Brugia malayi Cytochrome P450 family protein 0.0262 0.068 0.8509
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0303 0.0517
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0063 0.0107
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0041 0.0449
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.024 0.062 0.805
Brugia malayi Casein kinase II, alpha chain 0.0153 0.0383 0.4797
Brugia malayi multidrug resistance protein 3 0.0047 0.0092 0.1151
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0025 0.0032 0.0418
Loa Loa (eye worm) hypothetical protein 0.0036 0.0063 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0026 0.0301
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Loa Loa (eye worm) cytochrome P450 0.024 0.062 0.6724
Schistosoma mansoni hypothetical protein 0.024 0.062 0.1058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0447 0.5578
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0073 0.0163 0.2043
Schistosoma mansoni hypothetical protein 0.0205 0.0523 0.0892
Plasmodium falciparum ABC transporter B family member 6, putative 0.0025 0.0032 0.084
Loa Loa (eye worm) multidrug resistance protein 3 0.0047 0.0092 0.0996
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0273 0.0709 0.2041
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.006 0.0727
Trichomonas vaginalis glutaminase, putative 0.0295 0.0771 0.9646
Giardia lamblia Hypothetical protein 0.0023 0.0026 0.0331
Brugia malayi follicle stimulating hormone receptor 0.0264 0.0685 0.858
Plasmodium falciparum small ubiquitin-related modifier 0.0035 0.006 0.157
Entamoeba histolytica casein kinase, putative 0.0153 0.0383 0.478
Toxoplasma gondii ck2 beta subunit 0.0114 0.0275 0.36
Trichomonas vaginalis casein kinase II beta chain, putative 0.0114 0.0275 0.3423
Leishmania major hypothetical protein, unknown function 0.0052 0.0108 0.0298
Entamoeba histolytica hypothetical protein 0.0043 0.0083 0.1014
Plasmodium falciparum ABC transporter B family member 5, putative 0.0025 0.0032 0.084
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.0303 0.3931
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0071 0.0044
Schistosoma mansoni multidrug resistance protein 0.0023 0.0026 0.0045
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0764 0.9564
Entamoeba histolytica P-glycoprotein-2 0.0047 0.0092 0.1123
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0056 0.0673
Brugia malayi ABC transporter 0.0023 0.0026 0.0331
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0114 0.0275 0.3423
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.0303 0.4799
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 0.0174
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0052 0.0108 0.135
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0071 0.0886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0285 0.0743 0.9305
Brugia malayi multidrug resistance related protein 1 0.0069 0.0154 0.1928
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0052 0.0108 0.0311
Schistosoma mansoni smdr1 0.0025 0.0032 0.0055
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0045 0.0086 0.006
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.006 0.0034
Echinococcus granulosus microtubule associated protein 2 0.2162 0.5863 0.5852
Trichomonas vaginalis casein kinase II beta chain, putative 0.0033 0.0055 0.0664
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0035 0.006 0.0103
Echinococcus granulosus multidrug resistance associated protein 1 0.0069 0.0154 0.0128
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0052 0.0108 0.1411
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0056 0.0702
Entamoeba histolytica hypothetical protein 0.0052 0.0108 0.1323
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.006 0.0824
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0052 0.0108 0.2814
Schistosoma mansoni casein kinase II beta subunit 0.0114 0.0275 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0736 0.9217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.044 0.549
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0037 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.0771 0.9652

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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