Detailed information for compound 1033903

Basic information

Technical information
  • TDR Targets ID: 1033903
  • Name: N-(6-oxo-5H-pyrido[5,6-c]isoquinolin-1-ium-2- yl)-2-piperidin-1-ylacetamide chloride
  • MW: 372.849 | Formula: C19H21ClN4O2
  • H donors: 2 H acceptors: 4 LogP: 3.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(n1)c1ccccc1c(n2)O)CN1CCCCC1.Cl
  • InChi: 1S/C19H20N4O2.ClH/c24-17(12-23-10-4-1-5-11-23)21-16-9-8-15-18(22-16)13-6-2-3-7-14(13)19(25)20-15;/h2-3,6-9H,1,4-5,10-12H2,(H,20,25)(H,21,22,24);1H
  • InChiKey: ZZWJHMIZGBBMGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(6-oxo-5H-pyrido[5,6-c]isoquinolin-1-ium-2-yl)-2-(1-piperidyl)acetamide chloride
  • N-(6-keto-5H-pyrido[5,6-c]isoquinolin-1-ium-2-yl)-2-piperidino-acetamide chloride
  • N-(6-oxo-5H-pyrido[5,6-c]isoquinolin-1-ium-2-yl)-2-piperidin-1-yl-ethanamide chloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens poly (ADP-ribose) polymerase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma brucei gambiense poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2, putative Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly ADP ribose polymerase 1 Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 1, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (adp ribose) polymerase 2 Get druggable targets OG5_128423 All targets in OG5_128423
Brugia malayi WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) poly(ADP-ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Entamoeba histolytica poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (ADP ribose) polymerase 1 Get druggable targets OG5_128423 All targets in OG5_128423
Neospora caninum hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Brugia malayi WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2-A, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 1, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly adp ribose polymerase 2 Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma brucei poly(adp-ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.003 0.0045 0.0045
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0048 0.0048
Loa Loa (eye worm) phosphatidylinositol 3 0.0273 0.0622 0.0622
Onchocerca volvulus 0.004 0.0069 0.0654
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0007 0.0007
Echinococcus granulosus bloom syndrome protein 0.0022 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Toxoplasma gondii thioredoxin reductase 0.0052 0.0098 0.0125
Schistosoma mansoni immunophilin 0.0053 0.0101 0.0101
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus multilocularis zinc finger protein 0.002 0.0023 0.0023
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0098 0.0095
Echinococcus multilocularis microtubule associated protein 2 0.0707 0.1648 0.1648
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0021 0.0021
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.002 0.0022 0.0118
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0273 0.0622 0.0617
Loa Loa (eye worm) beta-lactamase 0.004 0.0069 0.0069
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0273 0.0622 0.0619
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.002 0.0022 0.0022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0006 0.0006
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.0101 0.0099
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0007 0.0007
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0101 0.0101
Schistosoma mansoni ap endonuclease 0.002 0.0021 0.0021
Brugia malayi follicle stimulating hormone receptor 0.0265 0.0601 0.0601
Echinococcus multilocularis tankyrase 0.0013 0.0005 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0101 0.0098
Onchocerca volvulus DNA ligase 3 homolog 0.0023 0.0029 0.0273
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0021 0.0024 0.0302
Schistosoma mansoni voltage-gated potassium channel 0.0163 0.0361 0.0361
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.0707 0.0705
Leishmania major DNA polymerase kappa, putative 0.002 0.0022 0.0019
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.002 0.0022 0.0067
Mycobacterium ulcerans hypothetical protein 0.004 0.0069 0.1485
Brugia malayi hypothetical protein 0.0454 0.1049 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4236 1 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0022 0.0022
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Plasmodium falciparum thioredoxin reductase 0.0018 0.0018 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.3151 0.7431 0.7431
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0031 0.0031
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0021 0.0024 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0053 0.0053
Echinococcus granulosus WGR domain containing protein 0.0054 0.0103 0.0103
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0031 0.0031
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0273 0.0622 0.0619
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0166 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0322 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.002 0.0022 0.0022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0069 0.1485
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0107 0.0107
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.002 0.0022 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0199 0.0199
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.044 0.044
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0053 0.0053
Trypanosoma brucei poly(adp-ribose) polymerase 0.0095 0.0201 0.0198
Echinococcus multilocularis expressed conserved protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0863 0.2018 0.2018
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.002 0.0022 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0077 0.0077
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus granulosus tankyrase 0.0013 0.0005 0.0005
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0101 0.0101
Entamoeba histolytica zinc finger protein, putative 0.0013 0.0005 0.0005
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.018 0.0402 0.0534
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Leishmania major hypothetical protein, conserved 0.002 0.0022 0.0019
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0022 0.0022
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0016 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0053 0.0053
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0021 0.0265
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0273 0.0622 0.0617
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0801 0.1871 0.1871
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1421 0.3337 0.3337
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0022 0.0022
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0124 0.1762
Loa Loa (eye worm) phosphatidylinositol 3 0.0273 0.0622 0.0622
Treponema pallidum catabolite gene activator (Crp) 0.002 0.0022 0.0486
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0081 0.0166 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0273 0.0622 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.2287 0.5388 0.5388
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.2284 0.538 0.538
Mycobacterium tuberculosis Conserved protein 0.004 0.0069 0.0843
Plasmodium vivax glutathione reductase, putative 0.0052 0.0098 0.1504
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0069 0.0069
Trichomonas vaginalis hypothetical protein 0.0014 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0528 0.1224 0.1224
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0022 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.3151 0.7431 0.7431
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4236 1 1
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0069 0.0066
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.003 0.003
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0273 0.0622 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0273 0.0622 0.0622
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis dullard protein, putative 0.0013 0.0005 0.0005
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0095 0.0201 0.0201
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1421 0.3337 0.3337
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis dullard protein, putative 0.0013 0.0005 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0005 0.0005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0022 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0022 0.0123
Plasmodium falciparum glutathione reductase 0.0018 0.0018 0.0202
Mycobacterium tuberculosis Conserved protein 0.004 0.0069 0.0843
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0101 0.156
Entamoeba histolytica hypothetical protein 0.0013 0.0005 0.0005
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.002 0.0022 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0053 0.0053
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.0287 0.445
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0622 0.0622
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.001 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.337 0.7949 0.7949
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0078 0.0075
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0045 0.0045
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0273 0.0622 0.0622
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4236 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0069 0.0068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0622 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0007 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0043 0.0077 0.0077
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.0287 0.445
Schistosoma mansoni immunophilin 0.0046 0.0084 0.0084
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.002 0.0022 0.0268
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.002 0.0022 0.0022
Loa Loa (eye worm) phosphatidylinositol 3 0.0273 0.0622 0.0622
Trichomonas vaginalis dullard protein, putative 0.0013 0.0005 0.0005
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0091 0.0865
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0273 0.0622 0.0622
Loa Loa (eye worm) runx1 0.0057 0.011 0.011
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0022 0.0022
Entamoeba histolytica protein kinase, putative 0.0033 0.0053 0.0053
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.002 0.0022 1
Mycobacterium leprae Probable lipase LipE 0.004 0.0069 0.0994
Plasmodium vivax hypothetical protein, conserved 0.0273 0.0622 1
Onchocerca volvulus 0.0155 0.0341 0.3255
Leishmania major phosphatidylinositol 4-kinase, putative 0.0273 0.0622 0.0619
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0027 0.0027
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.002 0.0022 0.0022
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0081 0.0166 0.0166
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0018 0.0017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0273 0.0622 0.083
Trypanosoma cruzi protein kinase A regulatory subunit 0.002 0.0022 0.0019
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0018 0.0018
Trichomonas vaginalis adenylate cyclase type, putative 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0095 0.0201 0.0201
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0029 0.0029
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0003 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0078 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0265 0.0265
Trichomonas vaginalis adenylate cyclase type III, putative 0.0014 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.0163 0.0361 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0022 0.0019
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.002 0.0022 0.0022
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0029 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.0163 0.0361 0.0361
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4236 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0273 0.0622 0.0619
Brugia malayi Inositol-1 0.0081 0.0166 0.0166
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0069 0.0069
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0018 0.0018
Echinococcus multilocularis inositol monophosphatase 1 0.0081 0.0166 0.0166
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.002 0.0022 0.0022
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0101 0.0101
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0005 0.0005
Echinococcus multilocularis nervana 2 0.002 0.0023 0.0023
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0273 0.0622 0.0622
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0069 0.0068
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.0101 0.0101
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0029 0.0028
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4236 1 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.002 0.0022 0.0118
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.2531 0.5965 0.5965
Brugia malayi Egg laying defective protein 4 0.002 0.0022 0.0022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0022
Loa Loa (eye worm) inositol-1 0.0081 0.0166 0.0166
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0014 0.0007 0.0007
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0039 0.0039
Mycobacterium ulcerans lipase LipD 0.004 0.0069 0.1485
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0273 0.0622 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Loa Loa (eye worm) MBCTL1 0.0056 0.0107 0.0107
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0121 0.0262 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.337 0.7949 0.7949
Leishmania major hypothetical protein, unknown function 0.0273 0.0622 0.0619
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0273 0.0622 0.0622
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0014 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0707 0.0705
Giardia lamblia Kinase, AGC PKA 0.0021 0.0024 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0013 0.0005 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0022 0.0022
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0045 0.0045
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0077 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.3151 0.7431 0.7431
Trypanosoma cruzi Flagellar Member 6 0.002 0.0022 0.0019
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0121 0.0262 0.0262
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0121 0.0262 0.0262
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0019
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0273 0.0622 0.0619
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0069 0.0068
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.003 0.0045 0.0045
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0005 0.0005
Trypanosoma brucei trypanothione reductase 0.0052 0.0098 0.0095
Loa Loa (eye worm) hypothetical protein 0.0072 0.0147 0.0147
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0022 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0018 0.0015
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0101 0.0101
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.0101 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.0622 0.0622
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0014 0.0007 0.0007
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.4236 1 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0016
Onchocerca volvulus 0.004 0.0069 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0069 0.0066
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.013 0.0282 0.0282
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0016 0.0016
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0069 0.0069
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0101 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0619 0.1441 0.1441
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0801 0.1871 0.1869
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0039 0.0039
Echinococcus granulosus nervana 2 0.002 0.0023 0.0023
Entamoeba histolytica protein kinase, putative 0.0031 0.0048 0.0048
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0091 0.0091
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0124 0.0124
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0149 0.0328 0.0328
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0005 0.0005
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.002 0.0022 0.0022
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.2284 0.538 0.538
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0022 0.0019
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0023 0.0029 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.2531 0.5965 0.5965
Brugia malayi N-terminal motif family protein 0.002 0.0022 0.0022
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0273 0.0622 0.0622
Loa Loa (eye worm) phosphatidylinositol 3 0.1421 0.3337 0.3337
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0018 0.0202
Trichomonas vaginalis esterase, putative 0.004 0.0069 0.0068
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.002 0.0022 0.0022
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0273 0.0622 0.0622
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1421 0.3337 0.3335
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4236 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0619 0.1441 0.1441
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Trichomonas vaginalis adenylate cyclase type, putative 0.0014 0.0007 0.0007
Trypanosoma brucei rac serine-threonine kinase, putative 0.0033 0.0053 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0077 0.0077
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0056 0.0107 0.0107
Loa Loa (eye worm) glutathione reductase 0.0052 0.0098 0.0098
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0265 0.0265
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0016 0.0016
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.176 0.4139 0.4137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0015
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Echinococcus multilocularis cGMP dependent protein kinase 1 0.002 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0069 0.0843
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0273 0.0622 0.0619
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0022 0.0019
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0091 0.0091
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0045 0.0045
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0021 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0015
Trichomonas vaginalis inositol monophosphatase, putative 0.0081 0.0166 0.0166
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0107 0.0107
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0101 0.0101
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0027 0.0027
Brugia malayi mbt repeat family protein 0.0049 0.0091 0.0091
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0199 0.0199
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0273 0.0622 0.0622
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0069 0.0843
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4236 1 1
Schistosoma mansoni zinc finger protein 0.0016 0.0012 0.0012
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0273 0.0622 0.0619
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0101 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0018 0.0015
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0021 0.0265
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0273 0.0622 0.0622
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0005 0.0005
Brugia malayi mbt repeat family protein 0.0049 0.0091 0.0091
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0082 0.017 0.017
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0069 0.0066
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0005 0.0005
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0025 0.0025
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0018 0.0018
Schistosoma mansoni zinc finger protein 0.002 0.0023 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0053 0.0053
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0022 0.0022
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0124 0.0124
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0273 0.0622 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.2287 0.5388 0.5388
Trichomonas vaginalis PIKK family atypical protein kinase 0.3151 0.7431 0.7431
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0594 0.1381 0.138
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.002 0.0022 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0801 0.1871 0.1871
Leishmania major DNA polymerase eta, putative 0.002 0.0022 0.0019
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0013 0.0005 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.337 0.7949 0.7949
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0098 0.0098
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0273 0.0622 0.083
Loa Loa (eye worm) phosphatidylinositol 3 0.0273 0.0622 0.0622
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0013 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0016 0.0016
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0101 0.0099
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.044 0.044
Loa Loa (eye worm) AGC/PKG protein kinase 0.002 0.0022 0.0022
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.002 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0273 0.0622 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.3617 0.8534 0.8534
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.003 0.0045 0.0045
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0029 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0053 0.0053
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0084 0.0084
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0273 0.0622 0.0619
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0273 0.0622 0.0622
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0021 0.0019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0124 0.3103
Leishmania major protein kinase, putative 0.002 0.0022 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0707 0.0705
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0015
Entamoeba histolytica hypothetical protein 0.0273 0.0622 0.0622
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.003 0.0045 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0199 0.0199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0199 0.0199
Echinococcus multilocularis serine protein kinase ATM 0.0801 0.1871 0.1871
Treponema pallidum cyclic nucleotide binding protein 0.002 0.0022 0.0486
Brugia malayi glutathione reductase 0.0052 0.0098 0.0098
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0022 0.0022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.012 0.012
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0166 0.0163
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0101 0.0101
Echinococcus granulosus poly adp ribose polymerase 2 0.0095 0.0201 0.0201
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0273 0.0622 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0069 0.0069
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0016
Mycobacterium leprae conserved hypothetical protein 0.0273 0.0622 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0139 0.0305 0.0305
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0528 0.1224 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.0893 0.2088 0.2088
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0014 0.0008 0.0005
Trichomonas vaginalis adenylate cyclase type III, putative 0.0014 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0801 0.1871 0.1871
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0014 0.0007 0.0007
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1421 0.3337 0.3335
Entamoeba histolytica protein kinase rad3, putative 0.0801 0.1871 0.1871
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0021 0.0019
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0022 0.0022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4236 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.0101 0.0096
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0166 0.0163
Leishmania major trypanothione reductase 0.0052 0.0098 0.0095
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0016 0.0016
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0095 0.0201 0.0201
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0273 0.0622 0.0622
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0893 0.2088 0.2088
Toxoplasma gondii AGC kinase 0.0031 0.0048 0.0058
Brugia malayi PHD-finger family protein 0.0026 0.0035 0.0035
Plasmodium falciparum thioredoxin reductase 0.0052 0.0098 0.1504
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0124 0.0124
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0273 0.0622 0.0619
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0273 0.0622 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Trypanosoma cruzi cAMP response protein 1 0.002 0.0022 0.0019
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0273 0.0622 0.0622
Brugia malayi hypothetical protein 0.0155 0.0341 0.0341
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0062 0.0062
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0021 0.0261
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0322 0.0319
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0255 0.3933
Schistosoma mansoni tankyrase 0.0013 0.0005 0.0005
Leishmania major DNA repair protein, putative 0.0023 0.0029 0.0026
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0018 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.1421 0.3337 0.3337
Loa Loa (eye worm) hypothetical protein 0.0044 0.0078 0.0078
Echinococcus granulosus poly ADP ribose polymerase 1 0.0174 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0301 0.0688 0.0688
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0174 0.0386 0.0386
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0027 0.0027
Entamoeba histolytica protein kinase 2, putative 0.0021 0.0024 0.0024
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0273 0.0622 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.2506 0.5906 0.5906
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.0573 0.9185
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.007
Echinococcus multilocularis Zinc finger, PHD finger 0.0273 0.0622 0.0622
Entamoeba histolytica hypothetical protein 0.0027 0.0039 0.0039
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0101 0.0099
Schistosoma mansoni immunophilin 0.0053 0.0101 0.0101
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0619 0.1441 0.1441
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.2531 0.5965 0.5965
Brugia malayi Thioredoxin reductase 0.0052 0.0098 0.0098
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0069 0.1485
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0139 0.0305 0.0305
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0069 0.0069
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0273 0.0622 0.0622
Loa Loa (eye worm) hypothetical protein 0.0155 0.0341 0.0341
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0273 0.0622 0.0622
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0081 0.0166 0.0217
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4236 1 1
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0014 0.0007 0.0007
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0528 0.1224 0.1224
Trypanosoma brucei unspecified product 0.0014 0.0007 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0007 0.0005
Echinococcus multilocularis dna polymerase eta 0.002 0.0022 0.0022
Schistosoma mansoni fkbp-rapamycin associated protein 0.0801 0.1871 0.1871
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0069 0.0069
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0273 0.0622 0.0622
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0273 0.0622 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.3151 0.7431 0.7431
Trichomonas vaginalis PIKK family atypical protein kinase 0.2842 0.67 0.6699
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0801 0.1871 0.1871
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0022 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0045 0.0045
Onchocerca volvulus 0.0454 0.1049 1
Leishmania major hypothetical protein, conserved 0.0273 0.0622 0.0619
Trypanosoma cruzi DNA repair protein, putative 0.0023 0.0029 0.0026
Schistosoma mansoni microtubule-associated protein tau 0.0707 0.1648 0.1648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0199 0.0199
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0893 0.2088 0.2804
Brugia malayi Bromodomain containing protein 0.0077 0.0157 0.0157
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0015
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0027 0.0027
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.4236 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0019
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0021 0.0064
Onchocerca volvulus 0.002 0.0022 0.0207
Toxoplasma gondii ABC1 family protein 0.004 0.0069 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0622 0.0622
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.0287 0.445
Schistosoma mansoni bromodomain containing protein 0.0065 0.0128 0.0128
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0014 0.0007 0.0007
Brugia malayi MH2 domain containing protein 0.0122 0.0265 0.0265
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0273 0.0622 0.0622
Entamoeba histolytica protein kinase, putative 0.0033 0.0053 0.0053
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0045 0.0045
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0908 0.2124 0.2124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0018 0.0015
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.002 0.0022 0.0022
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0014 0.0007 0.0007
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0174 0.0386 0.0386
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.0067
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0018 0.0018
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0022 0.0022
Echinococcus multilocularis patatin phospholipase domain containing protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0049 0.0091 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0005 0.0002
Trypanosoma cruzi Protein kinase B 0.0023 0.0029 0.0026
Leishmania major phosphatidylinositol 3-kinase, putative 0.0273 0.0622 0.0619
Onchocerca volvulus 0.0273 0.0622 0.5928
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0121 0.0262 0.0262
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.002 0.0022 0.0022
Mycobacterium ulcerans transmembrane transport protein 0.002 0.0022 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.3151 0.7431 0.7431
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0273 0.0622 0.0622
Toxoplasma gondii target of rapamycin (TOR), putative 0.3151 0.7431 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0069 0.0843
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0098 0.1328
Entamoeba histolytica hypothetical protein 0.0273 0.0622 0.0622
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0273 0.0622 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0068
Echinococcus multilocularis cGMP dependent protein kinase 1 0.002 0.0022 0.0022
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0273 0.0622 0.0622
Trypanosoma brucei DNA repair protein, putative 0.0023 0.0029 0.0026
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0021 0.0463
Brugia malayi Bromodomain containing protein 0.0039 0.0068 0.0068
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.003 0.003
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0024 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0069 0.0068
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.002 0.0022 0.0022
Trypanosoma brucei protein kinase A regulatory subunit 0.002 0.0022 0.0019
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0091 0.0091
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0014 0.0007 0.0007
Brugia malayi FAT domain containing protein 0.0619 0.1441 0.1441
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0101 0.0096
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0273 0.0622 0.0622
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0069 0.0068
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0005 0.0005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0021 0.0019
Plasmodium falciparum glutathione reductase 0.0052 0.0098 0.1504
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.0287 0.4542
Echinococcus granulosus zinc finger protein 0.002 0.0023 0.0023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0021 0.0021
Schistosoma mansoni inositol monophosphatase 0.0081 0.0166 0.0166
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0023 0.0029 0.0026
Echinococcus granulosus cGMP dependent protein kinase 1 0.002 0.0022 0.0022
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0072 0.0146 0.2126
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0018 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.337 0.7949 0.7949
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0023 0.0023
Trypanosoma cruzi cAMP response protein 1, putative 0.002 0.0022 0.0019
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0273 0.0622 0.0622
Brugia malayi Protein kinase domain containing protein 0.0033 0.0053 0.0053
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0166 0.0163
Trypanosoma cruzi cAMP binding protein, putative 0.002 0.0022 0.0019
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0069 0.0843
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0273 0.0622 0.0622
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0273 0.0622 0.0622
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0021 0.0021
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0149 0.0328 0.0328
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0273 0.0622 0.083
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0273 0.0622 0.0619
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0801 0.1871 0.1869
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0273 0.0622 0.0622
Mycobacterium ulcerans transcriptional regulatory protein 0.002 0.0022 0.0118
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.012 0.012
Echinococcus granulosus poly (ADP ribose) polymerase 0.0054 0.0103 0.0103
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0801 0.1871 0.1871
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0622 0.0622
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0273 0.0622 0.0622
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0273 0.0622 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.0101 0.156
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Giardia lamblia Phosphatidylinositol 4-kinase 0.0273 0.0622 0.0617
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0801 0.1871 0.1871
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0018 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.2287 0.5388 0.5388
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0003 0.0003
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0018 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0801 0.1871 0.1871
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0273 0.0622 0.0622
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0255 0.3933
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0255 0.3933
Leishmania major hypothetical protein, conserved 0.004 0.0069 0.0066
Leishmania major hypothetical protein, conserved 0.002 0.0022 0.0019
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0006 0.0006
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0322 0.0319
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0022 0.0123
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0014 0.0007 0.0007
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2003 0.4716 0.4715
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.002 0.0022 0.0022
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Mycobacterium tuberculosis Probable reductase 0.0118 0.0255 0.3933
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0149 0.0328 0.0328
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0018 0.0202
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.1421 0.3337 0.3337
Loa Loa (eye worm) hypothetical protein 0.004 0.0069 0.0069
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0098 0.0098
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0043 0.0077 0.0077
Brugia malayi Tnks protein 0.0013 0.0005 0.0005
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.002 0.0022 0.0019
Schistosoma mansoni similar to Protein C20orf152 homolog 0.002 0.0022 0.0022
Giardia lamblia GTOR 0.4236 1 1
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.002 0.0022 0.0207
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0101 0.0099
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0069 0.0069
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0045 0.0045
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0255 0.3933
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1421 0.3337 0.3335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0622 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.275 0.6483 0.6483
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus multilocularis nervana 2 0.002 0.0023 0.0023
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.337 0.7949 0.7949
Echinococcus granulosus dna polymerase eta 0.002 0.0022 0.0022
Echinococcus granulosus cGMP dependent protein kinase 0.002 0.0022 0.0022
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.002 0.0022 0.0268
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0045 0.0045
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1421 0.3337 0.3335
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0022 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.1421 0.3337 0.3337
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0273 0.0622 0.083
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0273 0.0622 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.1421 0.3337 0.3337
Leishmania major hypothetical protein, conserved 0.0023 0.0029 0.0026
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0255 0.3933
Echinococcus granulosus voltage gated potassium channel 0.0043 0.0077 0.0077
Leishmania major protein kinase A regulatory subunit, putative 0.002 0.0022 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0019
Mycobacterium ulcerans beta-lactamase 0.004 0.0069 0.1485
Plasmodium falciparum cGMP-dependent protein kinase 0.002 0.0022 0.0277
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0091 0.0091
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0021 0.0019
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0273 0.0622 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0273 0.0622 0.0622
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0029 0.0026
Echinococcus granulosus nervana 2 0.002 0.0023 0.0023
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0101 0.0101
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1421 0.3337 0.3337
Leishmania major phosphatidylinositol kinase, putative 0.0273 0.0622 0.0619
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0273 0.0622 0.0619
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0095 0.0201 0.0198
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3373 0.7957 0.7956
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0039 0.0039
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.0101 0.244
Plasmodium vivax hypothetical protein 0.0273 0.0622 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0801 0.1871 0.1871
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0801 0.1871 0.1871
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.0601 0.0601
Giardia lamblia DINP protein human, muc B family 0.002 0.0022 0.0017
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0273 0.0622 0.083
Echinococcus multilocularis 0.0013 0.0005 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0024 0.0024
Onchocerca volvulus 0.0273 0.0622 0.5928
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0022 0.0231
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0121 0.0262 0.0262
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0018 0.0017
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0273 0.0622 0.0619
Echinococcus multilocularis fk506 binding protein 0.0053 0.0101 0.0101
Onchocerca volvulus Tankyrase homolog 0.0013 0.0005 0.0052
Onchocerca volvulus 0.0049 0.0091 0.0865
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0022 0.0022
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0107 0.0107
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus multilocularis voltage gated potassium channel 0.0043 0.0077 0.0077
Entamoeba histolytica hypothetical protein 0.0801 0.1871 0.1871
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0069 0.0843
Echinococcus granulosus patatin phospholipase domain containing protein 0.002 0.0022 0.0022
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0273 0.0622 1
Trypanosoma cruzi target of rapamycin kinase 3 0.3373 0.7957 0.7956
Treponema pallidum catabolite gene activator 0.002 0.0022 0.0486
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.003 0.0045 0.0045
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0016 0.0016
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0124 0.0121
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0021 0.0021
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.4236 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0199 0.0199
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0273 0.0622 0.0622
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0273 0.0622 0.0622
Leishmania major protein kinase, putative 0.002 0.0022 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0622 0.0622
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0101 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0007 0.0005
Giardia lamblia Hypothetical protein 0.0273 0.0622 0.0617
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.002 0.0022 0.0023
Brugia malayi beta-lactamase family protein 0.004 0.0069 0.0069
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0101 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0273 0.0622 0.0622
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3373 0.7957 0.7956
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0273 0.0622 0.0619
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0021 0.0024 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0101 0.0101
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0045 0.0045
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0273 0.0622 1
Mycobacterium ulcerans hypothetical protein 0.002 0.0022 0.0118
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0801 0.1871 0.1871
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0273 0.0622 1
Loa Loa (eye worm) phosphatidylinositol 3 0.4236 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0273 0.0622 0.0622
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0045 0.0045
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0072 0.0146 0.2256
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0068 0.0137 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0022 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.0166 0.0166
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0149 0.0328 0.0328
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0078 0.0075
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0107 0.0107
Treponema pallidum cyclic nucleotide binding protein 0.002 0.0022 0.0486
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0124 0.0124
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0273 0.0622 0.0622
Brugia malayi beta-lactamase 0.004 0.0069 0.0069
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0174 0.0386 0.0386
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.004 0.0069 0.0069
Echinococcus granulosus inositol monophosphatase 1 0.0081 0.0166 0.0166
Trypanosoma brucei ISWI complex protein 0.0016 0.0012 0.0009
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1421 0.3337 0.3335
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0045 0.0045
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0273 0.0622 0.0622
Entamoeba histolytica hypothetical protein 0.0273 0.0622 0.0622
Echinococcus granulosus dna polymerase kappa 0.002 0.0022 0.0022
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0273 0.0622 0.0622
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0022 0.0022
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.0255 0.4033
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4236 1 1
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0095 0.0201 0.0198
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0091 0.0091
Trypanosoma brucei cAMP response protein 1, putative 0.002 0.0022 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0019
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0801 0.1871 0.1869
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0273 0.0622 0.0619
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0021 0.0113
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0273 0.0622 0.0622
Mycobacterium leprae conserved hypothetical protein 0.004 0.0069 0.0994
Leishmania major phosphatidylinositol kinase related protein, putative 0.0273 0.0622 0.0619
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1421 0.3337 0.3337
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0021 0.0021
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0594 0.1381 0.138
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0199 0.0199
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0022 0.0019
Trypanosoma brucei unspecified product 0.0014 0.0007 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0454 0.1049 0.1049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0622 0.0622
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0069 0.0843
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0019
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0069 0.0843
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0016 0.0016
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.002 0.0249
Toxoplasma gondii hypothetical protein 0.005 0.0093 0.0119
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Trypanosoma brucei cAMP binding protein, putative 0.002 0.0022 0.0019
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Loa Loa (eye worm) RecQ helicase 0.0022 0.0027 0.0027
Echinococcus multilocularis Protein lozenge 0.0057 0.011 0.011
Mycobacterium tuberculosis Conserved protein 0.004 0.0069 0.0843
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0199 0.0199
Echinococcus multilocularis 0.0273 0.0622 0.0622
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0022 0.0022
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Onchocerca volvulus 0.002 0.0022 0.0207
Brugia malayi beta-lactamase family protein 0.004 0.0069 0.0069
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.002 0.0022 0.0017
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0007 0.0007
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0081 0.0166 0.4327
Echinococcus granulosus single minded 2 0.0014 0.0007 0.0007
Trypanosoma brucei unspecified product 0.002 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0084 0.0084
Leishmania major hypothetical protein, unknown function 0.002 0.0022 0.0019
Echinococcus granulosus serine protein kinase ATM 0.0801 0.1871 0.1871
Trichomonas vaginalis immunophilin, putative 0.0053 0.0101 0.0101
Entamoeba histolytica hypothetical protein 0.0013 0.0005 0.0005
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0029 0.0028
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0101 0.0101
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0023 0.0023
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0022 0.0022
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.002 0.0022 0.0268
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0273 0.0622 0.0622
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0273 0.0622 0.0622
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0084 0.0084
Echinococcus granulosus cGMP dependent protein kinase 1 0.002 0.0022 0.0022
Leishmania major cyclic nucleotide-binding protein-like protein 0.002 0.0022 0.0019
Leishmania major phosphatidylinositol 3-kinase, putative 0.1421 0.3337 0.3335
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0273 0.0622 0.0622
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0022 0.0019
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4236 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.0025 0.0025
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0077 0.0077
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0018 0.0202
Echinococcus multilocularis dna polymerase kappa 0.002 0.0022 0.0022
Brugia malayi Cyclic-nucleotide gated cation channel 0.003 0.0045 0.0045
Plasmodium vivax hypothetical protein, conserved 0.004 0.0069 0.1029
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0074 0.0074
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.002 0.0022 0.0022
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0091 0.0091
Onchocerca volvulus 0.004 0.0069 0.0654
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0273 0.0622 0.0622
Schistosoma mansoni ap endonuclease 0.002 0.0021 0.0021
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0101 0.0099
Mycobacterium ulcerans regulatory protein 0.002 0.0022 0.0118
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.0009
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0016 0.0012 0.0009
Schistosoma mansoni lozenge 0.0057 0.011 0.011
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0022 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.2506 0.5906 0.5906
Mycobacterium ulcerans hypothetical protein 0.002 0.0022 0.0118
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0078 0.0075
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.1137 0.2665 0.2665
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0199 0.0199
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0029 0.0029
Loa Loa (eye worm) phosphatidylinositol 3 0.0273 0.0622 0.0622
Brugia malayi WGR domain containing protein 0.0095 0.0201 0.0201
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0619 0.1441 0.1441
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0124 0.3103
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0022 0.0022
Trypanosoma brucei Flagellar Member 6 0.002 0.0022 0.0019
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0045 0.0045
Toxoplasma gondii exonuclease III APE 0.002 0.0021 0.0022
Loa Loa (eye worm) phosphatidylinositol kinase 0.0273 0.0622 0.0622
Brugia malayi WGR domain containing protein 0.0174 0.0386 0.0386
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0022 0.0022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0018 0.0015
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0022 0.0022
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0091 0.0091
Mycobacterium tuberculosis Conserved protein 0.002 0.0022 0.0067
Loa Loa (eye worm) hypothetical protein 0.0619 0.1441 0.1441
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0029
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0018 0.0015
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0018 0.0015
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0121 0.0262 0.0262
Leishmania major fk506-binding protein 1-like protein 0.0053 0.0101 0.0099
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.002 0.0022 0.0067
Entamoeba histolytica hypothetical protein 0.0013 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.0022
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0132 0.0288 0.0288
Toxoplasma gondii FATC domain-containing protein 0.0801 0.1871 0.2513
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0022
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0018 0.0017
Leishmania major hypothetical protein, conserved 0.002 0.0022 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.1421 0.3337 0.3337
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0528 0.1224 0.1222
Trichomonas vaginalis adenylate cyclase type, putative 0.0014 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.2284 0.538 0.538
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0273 0.0622 0.0619
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0045 0.0045
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.0707 0.0705
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0018 0.0017
Loa Loa (eye worm) tnks protein 0.0013 0.0005 0.0005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0021 0.0016
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0005 0.0005
Schistosoma mansoni inositol monophosphatase 0.0081 0.0166 0.0166
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0273 0.0622 0.0622
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0007 0.0007
Leishmania major regulatory subunit of protein kinase a-like protein 0.002 0.0022 0.0019
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0098 0.1504
Echinococcus granulosus microtubule associated protein 2 0.0707 0.1648 0.1648
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0121 0.0262 0.0262
Echinococcus multilocularis poly (ADP ribose) polymerase 0.004 0.0069 0.0069
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0361 0.5679
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0273 0.0622 0.0622
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0622 0.0622
Loa Loa (eye worm) hypothetical protein 0.0454 0.1049 0.1049
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0053 0.0053
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.3151 0.7431 0.7431
Trichomonas vaginalis PIKK family atypical protein kinase 0.2287 0.5388 0.5388
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0016

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1110 nM Effective concentration required to inhibit P388D1 cell death by 50% ChEMBL. 12825952
IC50 (binding) = 150 nM Inhibitory activity against Poly (ADP-ribose) polymerase 1 ChEMBL. 12825952

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 12825952

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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